{"id":7897,"date":"2014-06-08T01:32:31","date_gmt":"2014-06-08T01:32:31","guid":{"rendered":"http:\/\/zydq.ybx8.cn\/?p=7897"},"modified":"2014-06-08T02:59:28","modified_gmt":"2014-06-08T02:59:28","slug":"%e8%8b%8f%e6%9c%a8","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=7897","title":{"rendered":"\u82cf\u6728"},"content":{"rendered":"

id=”” align=”alignleft” width=”600″]\"\u82cf\u6728 \u82cf\u6728[\/caption]<\/p>\n

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\n\u663e\u5fae\u9274\u522b \u5fc3\u6750\u6a2a\u5207\u9762\uff1a\u5c04\u7ebf\u5bbd1-2\u5217\u7ec6\u80de\u3002\u5bfc\u7ba1\u7c7b\u5706\u5f62\uff0c\u76f4\u5f84\u7ea6\u81f3160\u03bcm\uff0c\u5e38\u542b\u9ec4\u68d5\u8272\u6216\u7ea2\u68d5\u8272\u7269\u3002\u6728\u7ea4\u7ef4\u591a\u89d2\u5f62\uff0c\u58c1\u6781\u539a\u3002\u6728\u8584\u58c1\u7ec6\u80de\u58c1\u539a\uff0c\u6728\u5316\uff0c\u6709\u7684\u542b\u8349\u9178\u9499\u65b9\u6676\u3002\u9ad3\u90e8\u8584\u58c1\u7ec6\u80de\u4e0d\u89c4\u5219\u591a\u89d2\u5f62\uff0c\u5927\u5c0f\u4e0d\u4e00\uff0c\u58c1\u5fae\u6728\u5316\uff0c\u5177\u7eb9\u5b54\u3002
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\u3010\u5316\u5b66\u6210\u4efd\u3011\u5fc3\u6750\u542b\u8272\u539f\u70f7\u7c7b\u5316\u5408\u7269\uff1a3-\uff083\u2019\uff0c4-\u4e8c\u7f9f\u57fa\u82c4\u57fa\uff09-7-\u7f9f\u57fa-4-\u8272\u539f\u70f7\u916e[3-\uff083\uff0c\u02ca4\u02ca-dihydroxybenzvl\uff09-7-hydroxychroman-4-one]\u5373\u662f3-\u53bb\u6c27\u82cf\u6728\u916eB\uff083-deoxysappane B\uff09\uff0c3-\uff083\u02ca\uff0c4\u02ca-\u4e8c\u7f9f\u57fa\u4e9a\u82c4\u57fa\uff09-7-\u7f9f\u57fa-4-\u8272\u539f\u70f7\u916e[3-\uff083\u02ca\uff0c4\u02ca-dihydroxybenzylidene\uff09-7-hydroxy chroman-4-one]\uff0c3-\uff083\u02ca\uff0c4\u02ca-\u4e8c\u7f9f\u57fa\u82c4\u57fa\uff09-3\uff0c7-\u4e8c\u7f9f\u57fa-4\u8272\u539f\u70f7\u916e[3-\uff083\u02ca\uff0c4\u02ca-dihydroxybenzyl\uff09-3\uff0c7-dihy-droxychroman-4-one]\u5373\u662f\u82cf\u6728\u916eB\uff08sappanone B\uff09\uff0c3-\uff083\u02ca\uff0c4\u02ca-\u4e8c\u7f9f\u57fa\u82c4\u57fa\uff09-4\uff0c7-\u4e8c\u7f9f\u57fa\u8272\u539f\u70f7\u9187\uff3b3-\uff083\u02ca 4\u02ca-dihydroxybenzyl\uff09-4\uff0c7-dihydroxy chromanol]\uff0c3\u02ca\uff083\u02ca\uff0c4\u02ca-\u4e8c\u7f9f\u57fa\u82c4\u57fa\uff09-7-\u7f9f\u57fa-4-\u7532\u6c27\u57fa\u8272\u539f\u70f7\u9187[3-\uff083\u02ca\uff0c4\u02ca-dihydroxybenzyl\uff09-7-hydroxy-4-methoxy chromanol\uff09\u7684\u5de6\u65cb\u4f53\u548c\u53f3\u65cb\u4f53\uff0c7-\u7f9f\u57fa-\uff084\u02ca-\u7f9f\u57fa\u4e9a\u82c4\u57fa\uff09-4-\u8272\u539f\u70f7\u916e\uff087-hydroxy-3-\uff084\u02ca-hydroxybenzylidene\uff09-chroman-4-one]\uff0c3\uff0c7-\u4e8c\u7f9f\u57fa-3-\uff084\u02ca-\u7f9f\u57fa\u82c4\u57fa\uff09-4-\u8272\u539f\u70f7\u916e\uff3b3\uff0c7-dihydroxy-3-\uff084\u02ca-hydroxybonzyl)chroman-4-one]\u5373\u662f3\u02ca-\u53bb\u6c27\u82cf\u6728\u916eB\uff083\u02ca-deoxysappanoneB\uff09\uff0c7-\u7f9f\u57fa-8-\u7532\u6c27\u57fa-3-\uff084\u02ca-\u7532\u6c27\u57fa\u4e9a\u82c4\u57fa\uff09-4-\u8272\u539f\u70f7\u916e[7-hydroxy-8-methoxy-3-\uff084\u02ca-methoxybenzylidene\uff09chroman-4-one]\uff0c3\uff0c4\uff0c7-\u4e09\u7f9f\u57fa-3-\uff084\u02ca-\u7f9f\u57fa\u82c4\u57fa\uff09\u8272\u539f\u70f7\uff3b3\uff0c4\uff0c7-trihydroxy-3-(4\u02ca-hydroxybenzyl)chroman]\uff0c\u82cf\u6728\u915a(sappanol)\uff0c\u8868\u82cf\u6728\u915a(episappanol)\uff0c3\u02ca-\u53bb\u6c27\u82cf\u6728\u915a(3\u02ca-deoxysappanol)\uff0c3\u02ca-O-\u7532\u57fa\u82cf\u6728\u915a(3\u02ca-O-methylsappanol)\uff0c3\u02ca-O-\u7532\u57fa\u8868\u82cf\u6728\u915a(3\u02ca-O-methylepisappanol)\uff0c4-O-\u7532\u57fa\u82cf\u6728\u915a(4-O-methyl sappanol)\uff0c4-O-\u7532\u57fa\u8868\u82cf\u6728\u915a(4-O-methylepisappanol)\u3002\u8fd8\u542b\u5df4\u897f\u82cf\u6728\u7d20(drazilin)\uff0c3\u02ca-O-\u7532\u57fa\u5df4\u897f\u82cf\u6728\u7d20(3\u02ca-O-methyl brazilin)\u548c\u5df4\u897f\u82cf\u6728\u7d20\u884d\u751f\u7269(brazilin derivatives)1\u53ca2\u3002\u53c8\u542b\u5546\u9646\u9ec4\u7d20(ombuin)\uff0c\u9f20\u674e\u7d20(rhamnetin)\uff0c\u69f2\u76ae\u7d20(quercetin)\u7b49\u9ec4\u916e\u7c7b\u548c4\uff0c4\u02ca-\u4e8c\u7f9f\u57fa-2\u02ca-\u7532\u6c27\u57fa\u67e5\u8033\u916e(4\uff0c4\u02ca-dihydroxy-2\u02ca-methoxychalcone)\uff0c2\u02ca-\u7532\u6c27\u57fa-3\uff0c4\uff0c4\u02ca-\u4e09\u7f9f\u57fa\u67e5\u8033\u916e(2\u02ca-methoxy-3\uff0c4\uff0c4\u02ca-trihydroxychalcone)\u5373\u662f\u82cf\u6728\u67e5\u8033\u916e(sappanchalcone)\u3002\u53c8\u542b\u4e8c\u82ef\u5e76\u73af\u6c27\u5e9a\u70f7\u7c7b\u5316\u5408\u7269\uff1a\u539f\u82cf\u6728\u7d20(protosappanin)A\u3001B\u3001C\u3001E-1\u3001E-2\u53ca10-O-\u7532\u57fa\u539f\u82cf\u6728\u7d20B(10-O-methylprotosappanin B)\u3002\u8fd8\u542b\u82cf\u6728\u82e6\u7d20(calsalpin)J\u3001P\uff0c\u4e8c\u5341\u516b\u9187(octacosanol)\uff0c\u03b2-\u8c37\u753e\u9187(\u03b2-sitosterol)\u53ca\u84b2\u516c\u82f1\u8d5b\u9187(taraxerol)\u3002<\/p>\n

\u3010\u836f\u7406\u4f5c\u7528\u3011
\n1\uff0e\u5bf9\u5faa\u73af\u7cfb\u7edf\u7684\u5f71\u54cd \u5bf9\u4e8e\u80be\u4e0a\u817a\u7d20\u6240\u81f4\u5c0f\u9f20\u80a0\u7cfb\u819c\u5fae\u5faa\u73af\u969c\u788d\uff0c\u82cf\u6728\u6c34\u714e\u9187\u63d0\u53d6\u6db2\u80fd\u663e\u7740\u4fc3\u8fdb\u5fae\u52a8\u8109\u8840\u6d41\u4fc3\u8fdb\u5fae\u5faa\u73af\u548c\u7ba1\u5f84\u7684\u6062\u590d\uff0c\u4f46\u5728\u6240\u8bd520\u79cd\u6d3b\u8840\u5316\u7600\u836f\u4e2d\u82cf\u6728\u7684\u4f5c\u7528\u4ec5\u5c5e\u4e2d\u7b49\u5f3a\u5ea6\u3002\u72ac\u9759\u6ce8\u82cf\u6728\u6c34\u714e\u9187\u63d0\u53d6\u6db2\u8fd8\u53ef\u589e\u52a0\u51a0\u8109\u6d41\u91cf\uff0c\u964d\u4f4e\u51a0\u8109\u963b\u529b\uff0c\u51cf\u5c11\u5fc3\u7387\uff0c\u51cf\u4f4e\u5de6\u5ba4\u4f5c\u529f\uff0c\u4f46\u589e\uff1b\u52a0\u5fc3\u808c\u8017\u6c27\u91cf\u3002\u5f53\u4ee520mg\uff08\u751f\u836f\uff09\/kg\u80a1\u52a8\u8109\u76f4\u63a5\u6ce8\u5c04\u65f6\uff0c\u662f\u6240\u8bd5\u6d3b\u8840\u5316\u7600\u836f\u4e2d\u552f\u4e00\u4e0d\u80fd\u663e\u7740\u589e\u52a0\u9ebb\u9189\u72ac\u5916\u5468\u8840\u6d41\u91cf\u7684\u836f\u7269\u3002
\n2\uff0e\u5bf9\u8840\u6db2\u7684\u5f71\u54cd \u5bf9\u4e8e\u9759\u6ce8\u9ad8\u5206\u5b50\u53f3\u65cb\u7cd6\u9150\u5f15\u8d77\u5b9e\u9a8c\u6027\u8840\u7600\u8bc1\u5bb6\u5154\u7684\u8840\u6db2\uff0c\u82cf\u6728\u6ce8\u5c04\u6db2\u5728\u8bd5\u7ba1\u5185\u80fd\u663e\u7740\u964d\u4f4e\u8840\u6db2\u7c98\u5ea6\u5728\u5404\u79cd\u5207\u901f\u4e0b\u82cf\u6728\u7684\u4f5c\u7528\u5747\u975e\u5e38\u663e\u7740\uff0c\u4f46\u5728\u6240\u8bd520\u79cd\u6d3b\u8840\u836f\u4e2d\u82cf\u6728\u7684\u4f5c\u7528\u4e3a\u8f83\u5f31\u8005\uff1b\u5bf9\u4e8e\u7ea2\u7ec6\u80de\u805a\u96c6\u6307\u6570\u82cf\u6728\u65e0\u663e\u7740\u5f71\u54cd\u3002\u5bf9\u4e8eADP\u8bf1\u5bfc\u7684\u5927\u9f20\u8840\u5c0f\u677f\u805a\u96c6\uff0c100mg\/ml\u7684\u82cf\u6728\u6709\u6291\u5236\u4f5c\u7528\u3002\u5df4\u897f\u82cf\u6728\u7d20\u884d\u751f\u72691\uff0c2\u5747\u6709\u6297\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u7684\u4f5c\u7528\u3002
\n3\uff0e\u6297\u764c\u4f5c\u7528 \u4ee5\u4eba\u65e9\u5e7c\u7c92\u767d\u8840\u75c5\u7ec6\u80de\u682aHL-60\u4e3a\u9776\u7ec6\u80de\uff0c\u82cf\u6728\u6c34\u63d0\u53d6\u6db20.5mg(\u751f\u836f)\/kg\u6709\u7ec6\u80de\u6bd2\u4f5c\u7528\uff0c\u5bf9\u5c0f\u9f20\u6dcb\u5df4\u7624\u7ec6\u80de\u682aYac-1\u3001\u4eba\u7ea2\u9ad3\u767d\u8840\u75c5\u7ec6\u80de\u682aK562\u53ca\u5c0f\u9f20\u6210\u7ea4\u7ef4\u7ec6\u80de\u682aL929\u82cf\u6728\u714e\u5242\u4e5f\u6709\u8f83\u5f3a\u4f5c\u7528\u3002EAC\u8377\u7624\u5c0f\u9f20\u82cf\u6728\u714e\u5242\u8179\u8154\u6ce8\u5c04\u4e5f\u80fd\u663e\u7740\u5ef6\u957f\u5176\u751f\u5b58\u65f6\u95f4\u3002\u5bf9\u4e8e\u5c0f\u9f20\u5b9e\u9a8c\u6027\u767d\u8840\u75c5\uff0c\u82cf\u6728\u4e5f\u80fd\u663e\u7740\u5ef6\u957fP388\u53caL1210\u7684\u751f\u5b58\u65f6\u95f4\uff0c1\uff1a1\u714e\u5242\u6bcf\u65e5\u8179\u8154\u6ce8\u5c040\uff0e1ml\u53ca0\uff0e2ml\uff0c\u8fde\u7eed7d\u7684\u5ef6\u957f\u767e\u5206\u7387\u5206\u522b\u4e3a97\uff0e8%\u3001107\uff0e8%\uff08P388\uff09\u53ca102\uff0e6%\u3001117\uff0e5%\uff08L1210\uff09\u3002\u65e5\u672c\u62a5\u544a\u82cf\u6728\u4e8e\u4f53\u5916\u5bf9HL-60\u7ec6\u80de\u7684\u6700\u4f4e\u6291\u5236\u6d53\u5ea6\u4e3a0\uff0e2%\uff0c\u5728\u6b64\u6d53\u5ea6\u4f5c\u7528\u4e0b\uff0c 3\u30016h\u540e\u6291\u5236\u7387\u5206\u522b\u4e3a20%\u53ca35%\uff0c\u589e\u52a0\u82cf\u6728\u6d53\u5ea6\uff0c\u6291\u5236\u4f5c\u7528\u589e\u5f3a\uff0c\u4f46\u5373\u4f7f\u82cf\u6728\u6d53\u5ea6\u4ecd\u4e3a0\uff0e2%\uff0c\u4f5c\u7528\u65f6\u95f4\u5ef6\u957f\u81f324h\uff0c\u5176\u5236\u7387\u4e5f\u53ef\u8fbe50%\u4ee5\u4e0a\u3002\u5728\u82cf\u6728\u4f5c\u7528\u4e0b\uff0cHL-60\u7684\u8c37\u6c28\u9170\u80fa\u5408\u6210\u9176\u7684\u6d3b\u6027\u4e5f\u53d7\u6291\u5236\uff0c\u6b64\u4f5c\u7528\u4e5f\u968f\u836f\u6d53\u5ea6\u589e\u52a0\u800c\u52a0\u5f3a\u3002\u6b64\u5916\uff0c\u82cf\u6728\u8fd8\u6709\u6291\u5236\u8bf1\u53d8\u6548\u679c\u3002
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