{"id":67597,"date":"2026-08-20T08:01:48","date_gmt":"2026-08-20T08:01:48","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=67597"},"modified":"2026-08-20T08:01:48","modified_gmt":"2026-08-20T08:01:48","slug":"%e5%90%8c%e8%a1%8c%e8%af%84%e5%ae%a1%e7%a0%94%e7%a9%b6%e8%ad%a6%e5%91%8a%ef%bc%9a%e8%be%89%e7%91%9e%e4%b8%8e%e8%8e%ab%e5%be%b7%e7%ba%b3%e7%96%ab%e8%8b%97%e6%ae%8b%e7%95%99dna%e8%bf%9c%e8%b6%85","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=67597","title":{"rendered":"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae"},"content":{"rendered":"<h1 class=\"wp-block-heading\" id=\"activity-name\">\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae<\/h1>\n<p 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class=\"wp-block-paragraph\">\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u91c7\u7528\u4e24\u79cd\u72ec\u7acb\u65b9\u6cd5\uff0c\u5bf9\u6709\u9650\u6570\u91cf\u7684\u8f89\u745e-BioNTech\u548c\u83ab\u5fb7\u7eb3modRNA\u65b0\u51a0\u75ab\u82d7\u74f6\u4e2d\u7684DNA\u6b8b\u7559\u91cf\u8fdb\u884c\u4e86\u5b9a\u91cf\u5206\u6790\u3002\u7814\u7a76\u5bf9\u8c61\u4e3a32\u4e2a\u75ab\u82d7\u74f6\uff0c\u6db5\u76d616\u4e2a\u4e0d\u540c\u6279\u6b21\u3002\u4f7f\u7528Qubit\u8367\u5149\u6cd5\u6d4b\u5b9a\u603bDNA\u542b\u91cf\uff0c\u4f7f\u7528\u5b9a\u91cfPCR\uff08qPCR\uff09\u68c0\u6d4b\u7279\u5b9aDNA\u9776\u70b9\uff1b\u540c\u65f6\u901a\u8fc7RNase A\u5904\u7406\u8bc4\u4f30RNA\u5e72\u6270\u5bf9DNA\u6d4b\u5b9a\u7684\u5f71\u54cd\uff0c\u5e76\u521d\u6b65\u5206\u6790\u4e86DNA\u7247\u6bb5\u957f\u5ea6\u53ca\u5176\u5bf9DNase I\u7684\u654f\u611f\u6027\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u7ed3\u679c\u663e\u793a\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li>\u8f89\u745e\u75ab\u82d7\u6bcf\u5242\u603bDNA\u542b\u91cf\u4e3a371\u20131,548\u7eb3\u514b\uff0c\u83ab\u5fb7\u7eb3\u4e3a1,130\u20136,280\u7eb3\u514b\uff1b<\/li>\n<li>\u591a\u4e2a\u8d28\u7c92DNA\u9776\u70b9\u7684\u7279\u5b9aDNA\u542b\u91cf\uff1a\u8f89\u745e\u4e3a0.22\u20137.28\u7eb3\u514b\/\u5242\uff0c\u83ab\u5fb7\u7eb3\u4e3a0.01\u20130.78\u7eb3\u514b\/\u5242\uff1b<\/li>\n<li>SV40\u542f\u52a8\u5b50-\u589e\u5f3a\u5b50-\u590d\u5236\u8d77\u59cb\u5e8f\u5217\uff08SV40 promoter-enhancer-ori\uff09\u4ec5\u5728\u8f89\u745e\u75ab\u82d7\u4e2d\u68c0\u6d4b\u5230\uff0c\u542b\u91cf\u4e3a0.25\u201323.72\u7eb3\u514b\/\u5242\uff1b<\/li>\n<li>\u4f7f\u7528Oxford Nanopore\u6d4b\u5e8f\u6280\u672f\u5206\u6790\u5176\u4e2d\u4e00\u4e2a\u6837\u672c\uff0c\u53d1\u73b0DNA\u7247\u6bb5\u5e73\u5747\u957f\u5ea6\u4e3a214\u78b1\u57fa\u5bf9\uff0c\u6700\u957f\u8fbe3.5\u5343\u78b1\u57fa\u5bf9\uff1b<\/li>\n<li>\u6bcf\u5242\u75ab\u82d7\u4e2d\u5305\u88f9\u4e8e\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08LNP\uff09\u4e2d\u7684\u8d28\u7c92DNA\u7247\u6bb5\u6570\u91cf\u4f30\u7b97\u4e3a1.23\u00d710\u2078\u81f31.60\u00d710\u00b9\u00b9\u4e2a\u3002<\/li>\n<\/ul>\n<p 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class=\"wp-block-paragraph\">\u7814\u7a76\u6307\u51fa\uff0c\u8f89\u745e\u75ab\u82d7\u4e2dSV40\u542f\u52a8\u5b50-\u589e\u5f3a\u5b50\u5e8f\u5217\u7684\u5b58\u5728\u5f15\u53d1\u91cd\u8981\u5b89\u5168\u9690\u60a3\u3002\u8be5\u7814\u7a76\u5f3a\u8c03\uff0c\u5728modRNA\u4ea7\u54c1\u4e2d\u8fdb\u884c\u6b8b\u7559\u8d28\u7c92DNA\u5b9a\u91cf\u5206\u6790\u65f6\uff0c\u5fc5\u987b\u8003\u8651\u68c0\u6d4b\u65b9\u6cd5\u7684\u5dee\u5f02\u3001LNP\u8f6c\u67d3\u6548\u7387\u7684\u63d0\u5347\u4ee5\u53ca\u591a\u6b21\u63a5\u79cd\u6240\u5e26\u6765\u7684\u6f5c\u5728\u5065\u5eb7\u98ce\u9669\u3002<img decoding=\"async\" title=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c4\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" 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\u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c5\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/VHHCQQWicLYKoRdC0phibB0feWF1rEJLVqIhWlluVcxZuza5jlADD8UeaUNicfLLsRCPRW6od5dGAFLQCYgZlicgYw\/640?wx_fmt=png&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1&amp;watermark=1#imgIndex=2\"><\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u80cc\u666f\u4e0e\u76ee\u7684\u6982\u8ff0\uff1a<\/strong>\u7531\u4e8e\u5316\u5b66\u5408\u6210\u5927\u5206\u5b50RNA\uff08\u8d85\u8fc7200\u4e2a\u78b1\u57fa\uff09\u6210\u672c\u9ad8\u4e14\u5bb9\u6613\u51fa\u9519\uff0c\u79d1\u5b66\u5bb6\u4eec\u901a\u5e38\u4f7f\u7528T7 RNA\u805a\u5408\u9176\u4eceDNA\u6a21\u677f\u5408\u6210\u4fee\u9970RNA\uff08modRNA\uff09\u3002\u8fd9\u4e9bDNA\u6a21\u677f\u901a\u5e38\u901a\u8fc7\u5316\u5b66\u5408\u6210\u77ed\u7247\u6bb5\u540e\u518d\u9176\u4fc3\u62fc\u63a5\u3001\u805a\u5408\uff0c\u5e76\u514b\u9686\u8fdb\u8d28\u7c92\u4e2d\u5b8c\u6210\u3002\u8d28\u7c92DNA\u53ef\u901a\u8fc7\u76f4\u63a5\u88c2\u89e3\u5927\u80a0\u6746\u83cc\u6216PCR\u6269\u589e\u76ee\u6807\u63d2\u5165\u7247\u6bb5\u8fdb\u884c\u7eaf\u5316\uff0c\u4e0d\u540c\u65b9\u6cd5\u4f1a\u5bfc\u81f4\u75ab\u82d7\u4e2d\u6b8b\u7559DNA\u7684\u7c7b\u578b\u548c\u6570\u91cf\u5dee\u5f02\u663e\u8457\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u75ab\u82d7\u5236\u9020\u5de5\u827a\u7684\u53d8\u5316\uff1a<\/strong>Moderna\u91c7\u7528\u7684\u662f\u4e0d\u7ecfPCR\u7684\u8d28\u7c92DNA\u7eaf\u5316\u65b9\u6cd5\uff0c\u800cPfizer\u5728\u83b7\u5f97FDA\u6279\u51c6\u540e\u4e5f\u4ece\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684PCR\u65b9\u6cd5\uff08\u5de5\u827a1\uff09\u8f6c\u5411\u4e86\u7c7b\u4f3cModerna\u7684PCR-free\u8d28\u7c92\u7eaf\u5316\u65b9\u6cd5\uff08\u5de5\u827a2\uff09\u3002\u7531\u4e8e\u5de5\u827a2\u4f7f\u7528\u4e86\u66f4\u5927\u7684\u8d28\u7c92\u6a21\u677f\uff087.8Kb\uff09\uff0c\u76f8\u6bd4\u5de5\u827a1\u7684PCR\u6269\u589e\u7247\u6bb5\uff084.2Kb\uff09\uff0c\u53ef\u80fd\u5bfc\u81f4\u75ab\u82d7\u4e2d\u6b8b\u7559DNA\u542b\u91cf\u663e\u8457\u589e\u52a0\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u6b8b\u7559DNA\u68c0\u6d4b\u7684\u6311\u6218\uff1a<\/strong>Pfizer\u7528\u4e8e\u68c0\u6d4b\u6b8b\u7559DNA\u7684qPCR\u65b9\u6cd5\u4ec5\u9488\u5bf9\u8d28\u7c92\u4e2d\u7684KAN\u57fa\u56e0\uff0c\u672a\u80fd\u5168\u9762\u8986\u76d6\u8d28\u7c92\u548c\u63d2\u5165\u5e8f\u5217\uff0c\u53ef\u80fd\u4f4e\u4f30\u4e86\u6b8b\u7559DNA\u7684\u5b9e\u9645\u6c34\u5e73\u3002\u6b64\u5916\uff0cDNase I\u9176\u5bf9RNA:DNA\u6742\u5408\u4f53\u7684\u964d\u89e3\u80fd\u529b\u6709\u9650\uff0c\u5bfc\u81f4\u67d0\u4e9b\u533a\u57df\u7684DNA\u96be\u4ee5\u6e05\u9664\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u8d28\u7c92\u7ed3\u6784\u5dee\u5f02\u4e0e\u6f5c\u5728\u98ce\u9669\uff1a<\/strong>Pfizer\uff08\u8f89\u745e\uff09\u4f7f\u7528\u7684\u8d28\u7c92\u4e3apcDNA3.1\u884d\u751f\u7269\uff0c\u5177\u5907SV40\u75c5\u6bd2\u7684\u590d\u5236\u8d77\u59cb\u70b9\u3001\u589e\u5f3a\u5b50\u548c\u542f\u52a8\u5b50\uff0c\u53ef\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u590d\u5236\u3002\u7814\u7a76\u6307\u51fa\uff0c\u8fd9\u4e9bSV40\u5e8f\u5217\u53ef\u80fd\u4e0e\u764c\u57fa\u56e0\u6fc0\u6d3b\u6216\u6291\u764c\u57fa\u56e0\u5931\u6d3b\u76f8\u5173\u3002McKernan\u7b49\u4eba\u57282023\u5e74\u901a\u8fc7RNA\u6d4b\u5e8f\u53d1\u73b0\uff0cPfizer\u548cModerna\u75ab\u82d7\u4e2d\u5747\u5b58\u5728\u9ad8\u62f7\u8d1d\u8d28\u7c92DNA\u6b8b\u7559\uff0c\u4e14Pfizer\u75ab\u82d7\u4e2d\u542b\u6709SV40\u542f\u52a8\u5b50\u5e8f\u5217\uff0c\u4f46\u8fd9\u4e9b\u4fe1\u606f\u672a\u5728EMA\u76d1\u7ba1\u6587\u4ef6\u4e2d\u62ab\u9732\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u65b9\u6cd5\u4e0e\u76ee\u6807\uff1a<\/strong>\u7814\u7a76\u56e2\u961f\u4ece\u52a0\u62ff\u5927\u5b89\u5927\u7565\u7701\u6536\u96c6\u4e8632\u74f6\u75ab\u82d7\u6837\u672c\uff0c\u4f7f\u7528qPCR\u548c\u8367\u5149\u5b9a\u91cf\u65b9\u6cd5\u68c0\u6d4b\u4e86\u6b8b\u7559DNA\u7684\u5177\u4f53\u5e8f\u5217\uff08\u5982spike\u57fa\u56e0\u3001\u8d28\u7c92\u590d\u5236\u8d77\u59cb\u70b9\u3001SV40\u542f\u52a8\u5b50\u7b49\uff09\u53ca\u603b\u91cf\uff0c\u5e76\u5206\u6790\u4e86DNA\u7247\u6bb5\u7684\u5927\u5c0f\u5206\u5e03\u548c\u662f\u5426\u88ab\u5305\u88c5\u8fdb\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08LNP\uff09\u3002\u6700\u540e\uff0c\u5c06\u8fd9\u4e9b\u6570\u636e\u4e0eVAERS\u7cfb\u7edf\u4e2d\u62a5\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\u8fdb\u884c\u6bd4\u5bf9\uff0c\u4ee5\u8bc4\u4f30\u6f5c\u5728\u5173\u8054\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u6750\u6599\u4e0e\u65b9\u6cd5<\/strong><\/p>\n<p class=\"wp-block-paragraph\"><strong>\u65b0\u51a0\u75ab\u82d7\u6837\u672c\u6279\u6b21<\/strong><br \/>\u7565&#8230;..\u3002\u8fd9\u4e9b\u672a\u5f00\u5c01\u7684\u75ab\u82d7\u74f6\u5747\u4fdd\u6301\u5b8c\u6574\uff0c\u74f6\u76d6\u672a\u88ab\u7834\u574f\uff0c\u6279\u53f7\u548c\u6709\u6548\u671f\u6e05\u6670\u53ef\u89c1\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u7565&#8230;..\u3002\u8fd1\u671f\u4f7f\u7528\u8fc7\u7684\u75ab\u82d7\u74f6\uff08\u5728\u6ce8\u5c04\u540e30\u5206\u949f\u5185\uff09\u4e5f\u88ab\u653e\u5165\u51b7\u51bb\u51dd\u80f6\u5305\u4e2d\uff0c\u5e76\u572812\u5c0f\u65f6\u5185\u9001\u8fbe\u5b9e\u9a8c\u5ba4\u51b0\u7bb1\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>qPCR\u5206\u6790\uff1aSpike\u3001ori\u53caSV40\u542f\u52a8\u5b50-\u589e\u5f3a\u5b50-\u590d\u5236\u8d77\u59cb\u5e8f\u5217\uff08SV40 promoter-enhancer-ori\uff09<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u75ab\u82d7\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a\u7cfb\u7edf\uff08VAERS\uff09\u6570\u636e\u5206\u6790<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u4f7f\u7528R\u8bed\u8a00\u7edf\u8ba1\u8ba1\u7b97\u73af\u5883\u5206\u6790VAERS\u6570\u636e\u5e93 [\u5f15\u752818]\uff0c\u6570\u636e\u8303\u56f4\u4e3a2020\u5e7412\u670817\u65e5\u81f32023\u5e7410\u67086\u65e5\u3002\u7f8e\u56fdVAERS\u6570\u636e\u53ef\u4e0b\u8f7d\u4e3a\u4e09\u4e2aCSV\u6587\u4ef6\uff0c\u5206\u522b\u5305\u542b\uff1a<\/p>\n<p class=\"wp-block-paragraph\">1\uff09\u6bcf\u4efd\u62a5\u544a\u7684\u57fa\u672c\u4fe1\u606f\uff1b<\/p>\n<p class=\"wp-block-paragraph\">2\uff09\u62a5\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u6216\u201c\u75c7\u72b6\u201d\uff1b<\/p>\n<p class=\"wp-block-paragraph\">3\uff09\u75ab\u82d7\u4fe1\u606f\uff0c\u5305\u62ec\u751f\u4ea7\u5546\u4e0e\u6279\u53f7 [\u5f15\u75289]\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u53e6\u6709\u4e00\u4efd\u975e\u7f8e\u56fd\uff08foreign\uff09VAERS\u6570\u636e\u96c6\uff0c\u5305\u542b\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5411\u76d1\u7ba1\u673a\u6784\u63d0\u4ea4\u7684\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a\u3002\u6bcf\u4efd\u62a5\u544a\u5206\u914d\u4e00\u4e2aVAERS ID\u7f16\u53f7\u4ee5\u4fdd\u62a4\u9690\u79c1\u3002\u4e3a\u5206\u6790\u7279\u5b9a\u75ab\u82d7\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u9700\u4f7f\u7528VAERS ID\u5c06\u4e09\u4efd\u6570\u636e\u6587\u4ef6\u5408\u5e76\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u4ec5\u7eb3\u5165COVID-19\u75ab\u82d7\u7c7b\u578b\uff1aCOVID19-1\uff08\u5355\u4ef7\uff09\u4e0eCOVID19-2\uff08\u53cc\u4ef7\uff09\u3002\u5176\u4ed6\u5206\u6790\u53d8\u91cf\u5305\u62ec\uff1aVAERS ID\u3001\u75ab\u82d7\u6279\u53f7\uff08VAX_LOT\uff09\u3001\u751f\u4ea7\u5546\uff08VAX_MANU\uff09\u3001\u4f4f\u9662\uff08HOSPITAL\uff09\u3001\u6b8b\u75be\uff08DISABLE\uff09\u3001\u6025\u8bca\u5c31\u8bca\uff08ER_ED_VISIT\uff09\u3001\u51fa\u751f\u7f3a\u9677\uff08BIRTH_DEFECT\uff09\u3001\u5371\u53ca\u751f\u547d\u4e8b\u4ef6\uff08L_THREAT\uff09\u4e0e\u6b7b\u4ea1\uff08DIED\uff09\u3002https:\/\/wxa.wxs.qq.com\/tmpl\/mw\/base_tmpl.html<\/p>\n<p class=\"wp-block-paragraph\">\u6570\u636e\u6309\u75ab\u82d7\u6279\u6b21\uff08VAX_LOT\uff09\u5206\u7ec4\uff0c\u7edf\u8ba1\u6bcf\u6279\u6b21\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u4e0e\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u62a5\u544a\u603b\u6570\u3002SAE\u5305\u62ec\u6b7b\u4ea1\u3001\u4f4f\u9662\u3001\u6025\u8bca\u3001\u6b8b\u75be\u3001\u51fa\u751f\u7f3a\u9677\u4e0e\u5371\u53ca\u751f\u547d\u4e8b\u4ef6\u3002\u7814\u7a76\u67e5\u8be2\u4e86\u7f8e\u56fd\u4e0e\u975e\u7f8e\u56fd\u6570\u636e\uff0c\u4f46\u4e3b\u8981\u7ed3\u679c\u4ec5\u62a5\u544a\u52a0\u62ff\u5927\u6279\u6b21\u3002\u52a0\u62ff\u5927\u62a5\u544a\u901a\u8fc7SPLTTYPE\u53d8\u91cf\u8bc6\u522b\uff0c\u5176\u524d\u4e24\u4e2a\u5b57\u7b26\u4e3a\u56fd\u5bb6\u4ee3\u7801\u201cCA\u201d\u3002\u7814\u7a76\u8fd8\u8ba1\u7b97\u4e86VAERS\u6570\u636e\u4e0espike\u3001ori\u53caSV40 DNA\u6c34\u5e73\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff0c\u5e76\u4f7f\u7528\u76ae\u5c14\u900a\u76f8\u5173\u7cfb\u6570\u8fdb\u884c\u7edf\u8ba1\u5206\u6790\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u6838\u9178\u9176\u654f\u611f\u6027\u8bc4\u4f30\uff08Assessment of Nuclease Sensitivity\uff09<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u7565<img decoding=\"async\" title=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c6\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c6\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/VHHCQQWicLYKoRdC0phibB0feWF1rEJLVqfrcVlOI4FuV74X2HPELQ2aXrqMwfBNN0iaCubeNtlL8Mib9rRAibl4wrA\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1&amp;watermark=1#imgIndex=3\" \/><img decoding=\"async\" title=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c7\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c7\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/VHHCQQWicLYKoRdC0phibB0feWF1rEJLVqfrcVlOI4FuV74X2HPELQ2aXrqMwfBNN0iaCubeNtlL8Mib9rRAibl4wrA\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1&amp;watermark=1#imgIndex=3\"><\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u8ba8\u8bba<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u5728\u6240\u8c03\u67e5\u7684\u5168\u90e832\u74f6\u75ab\u82d7\u4e2d\u5747\u68c0\u6d4b\u5230\u6b8b\u7559DNA\u3002\u6765\u81ea\u540c\u4e00\u6279\u6b21\u7684\u591a\u4e2a\u75ab\u82d7\u74f6\u5728\u5404\u4e2a\u68c0\u6d4b\u9776\u70b9\u4e0a\u7684DNA\u542b\u91cf\u975e\u5e38\u63a5\u8fd1\uff0c\u663e\u793a\u51fa\u68c0\u6d4b\u65b9\u6cd5\u7684\u53ef\u9760\u6027\u3001\u53ef\u91cd\u590d\u6027\u4ee5\u53ca\u6279\u6b21\u5185\u7684\u4e00\u81f4\u6027\u3002\u8fd9\u4e9b\u6765\u81ea\u52a0\u62ff\u5927\u5206\u53d1\u75ab\u82d7\u74f6\u7684\u6570\u636e\uff0c\u4e0e\u591a\u9879\u5df2\u53d1\u8868\u548c\u672a\u53d1\u8868\u7684\u7814\u7a76\u62a5\u544a\uff08\u5982McKernan\u3001Buckhaults\u3001Konig\u3001Raoult\u3001K\u00e4mmerer\u3001Wang\uff09\u5173\u4e8emodRNA\u75ab\u82d7\u4e2dDNA\u6b8b\u7559\u7684\u53d1\u73b0\u4e00\u81f4\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u5728qPCR\u68c0\u6d4b\u4e2d\uff0c\u83ab\u5fb7\u7eb3\u75ab\u82d7\u7684DNA\u6d53\u5ea6\u6700\u4f4e\uff0c\u4f46\u5728Qubit\u8367\u5149\u6cd5\u4e2d\u5374\u662f\u6700\u9ad8\u3002\u83ab\u5fb7\u7eb3\u5404\u74f6\u4e4b\u95f4\u7684DNA\u542b\u91cf\u975e\u5e38\u4e00\u81f4\uff0c\u8868\u660e\u5176\u751f\u4ea7\u8fc7\u7a0b\u66f4\u4e3a\u7a33\u5065\u548c\u6807\u51c6\u5316\u3002\u9664\u6279\u6b21AS0467D\u5916\uff0c\u83ab\u5fb7\u7eb3\u75ab\u82d7\u74f6\u4e2d\u7684ori\u5e8f\u5217\u542b\u91cf\u666e\u904d\u4f4e\u4e8e\u523a\u7a81\u86cb\u767d\u5e8f\u5217\uff0c\u6697\u793a\u5176\u5728\u53bb\u9664\u8d28\u7c92DNA\u65b9\u9762\u66f4\u4e3a\u6709\u6548\u3002\u53ef\u80fd\u662f\u540c\u6e90\u4fee\u9970RNA\u901a\u8fc7\u4e0e\u6a21\u677fDNA\u5f62\u6210\u6742\u5408\u7ed3\u6784\uff0c\u963b\u6b62\u4e86\u5176\u88ab\u964d\u89e3\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cAS0467D\u4e3a\u53cc\u4ef7BA.1\u75ab\u82d7\uff0c\u5176\u7531\u4e24\u79cd\u4e0d\u540c\u7eaf\u5ea6\u7684mRNA\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08LNP\uff09\u6df7\u5408\u800c\u6210\u3002\u7531\u4e8eDNase I\u5728RNA-DNA\u6742\u5408\u7269\u5b58\u5728\u65f6\u6d3b\u6027\u53d7\u6291\uff0c\u4e0d\u540c\u7684modRNA\u6784\u5efa\u53ef\u80fd\u5177\u6709\u4e0d\u540c\u7684\u4e8c\u7ea7\u7ed3\u6784\u6216\u4e0eDNA\u7684\u6742\u5408\u6f5c\u529b\uff0c\u4ece\u800c\u5f71\u54cd\u9176\u6d3b\u6027\u3002\u8fd9\u79cdspike\u4e0eori\u5e8f\u5217\u4e4b\u95f4\u7684\u6781\u7aef\u5dee\u5f02\u53cd\u6620\u51fa\u4e0d\u5e94\u5b58\u5728\u7684\u5236\u9020\u504f\u5dee\uff0c\u5f3a\u8c03\u76d1\u7ba1\u673a\u6784\u4e0d\u5e94\u4ec5\u4f9d\u8d56\u5355\u4e00PCR\u68c0\u6d4b\u6765\u8bc4\u4f30\u6700\u7ec8\u836f\u54c1\u4e2d\u7684\u8d28\u7c92DNA\u6b8b\u7559\u91cf\u3002<\/p>\n<p class=\"wp-block-paragraph\">DNA\u6d53\u5ea6\u6700\u9ad8\u7684\u75ab\u82d7\u74f6\u6765\u81ea\u8f89\u745e\u5355\u4ef7\u75ab\u82d7\u7d2b\u76d6\u6279\u6b21\uff08PBS\u7f13\u51b2\u6db2\u914d\u65b9\uff09\uff0c\u9700\u7a00\u91ca\u540e\u4f7f\u7528\u30022021\u5e7410\u670829\u65e5\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u5c06\u914d\u65b9\u6539\u4e3aTris\/\u8517\u7cd6\u7f13\u51b2\u6db2\uff0c\u7528\u4e8e\u7070\u76d6\u6210\u4eba\u75ab\u82d7\u548c\u6a59\u76d6\u513f\u7ae5\u75ab\u82d7\uff086\u201311\u5c81\uff09\u3002\u6b64\u4e3e\u65e8\u5728\u63d0\u5347\u7a33\u5b9a\u6027\u3001\u7b80\u5316\u50a8\u5b58\u8981\u6c42\uff0c\u5e76\u63d0\u4f9b\u5373\u7528\u578b\u4ea7\u54c1\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u7d2b\u76d6\u8f89\u745e\u6279\u6b21\u4e5f\u4e0eVAERS\u7cfb\u7edf\u4e2d\u62a5\u544a\u7684\u6700\u9ad8\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u548c\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u6570\u91cf\u76f8\u5173\u3002\u867d\u7136\u539f\u56e0\u5c1a\u4e0d\u660e\u786e\uff0c\u4f46PBS\u7f13\u51b2\u6db2\u53ef\u80fd\u5bfc\u81f4\u6700\u7ec8\u4ea7\u54c1\u4e2d\u51fa\u73b0\u53ef\u89c1\u9897\u7c92\uff0c\u53ef\u80fd\u4e0e\u5fae\u6813\u585e\u548c\u708e\u75c7\u53cd\u5e94\u7b49\u6bd2\u6027\u76f8\u5173 [\u5f15\u752830]\u3002\u6b64\u5916\uff0c\u8102\u8d28\u6c34\u89e3\u548c\u919b\u7c7b\u751f\u6210\u5bfc\u81f4\u7684\u8102\u8d28\u6742\u8d28\u4e5f\u88ab\u89c2\u5bdf\u5230\uff0c\u5f62\u6210\u8102\u8d28\u52a0\u5408\u7269\uff0c\u53ef\u80fd\u5177\u6709\u6bd2\u7406\u5b66\u5f71\u54cd\u3002Tris\u7f13\u51b2\u6db2\u53ef\u4f5c\u4e3a\u201c\u919b\u7c7b\u5438\u6536\u5242\u201d\uff0c\u51cf\u5c11LNP\u6742\u8d28\uff0c\u8fd9\u4e00\u673a\u5236\u5df2\u88ab\u83ab\u5fb7\u7eb3\u79d1\u5b66\u5bb6\u8bc1\u5b9e\u3002\u52a0\u5408\u7269\u53ef\u80fd\u5bfc\u81f4modRNA\u529f\u80fd\u4e27\u5931\uff0c\u5f71\u54cdmRNA\u7684\u9ad8\u7ea7\u7ed3\u6784\u3001\u52a8\u529b\u5b66\uff0c\u751a\u81f3\u5f15\u53d1\u672a\u77e5\u673a\u5236\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u5373\u4f7f\u7ecf\u5386\u4e86\u4e09\u5e74\u7684\u751f\u4ea7\u7ecf\u9a8c\uff0c\u75ab\u82d7\u6279\u6b21\u95f4\u548c\u6279\u6b21\u5185\u7684DNA\u6b8b\u7559\u5dee\u5f02\u4ecd\u7136\u5b58\u5728\u3002\u5c24\u5176\u662f\u8f89\u745e\u75ab\u82d7\uff0c\u8fd9\u79cd\u6301\u7eed\u7684\u5dee\u5f02\u6027\u53ef\u80fd\u6bd4\u5355\u7eaf\u964d\u4f4e\u6742\u8d28\u6c34\u5e73\u66f4\u4e3a\u6839\u672c\uff0c\u56e0\u4e3a\u5b83\u53cd\u6620\u51fa\u751f\u4ea7\u8fc7\u7a0b\u7684\u4e0d\u4e00\u81f4\u6027\uff0c\u4e5f\u53ef\u80fd\u5f71\u54cd\u5176\u4ed6\u5de5\u827a\u6216\u4ea7\u54c1\u76f8\u5173\u6742\u8d28\u3002\u4e0d\u540c\u4f9b\u5e94\u5546\u6216\u6279\u6b21\u7684DNase\u9176\u7eaf\u5ea6\u548c\u7a33\u5b9a\u6027\u53ef\u80fd\u5b58\u5728\u5dee\u5f02\u3002IVT\uff08\u4f53\u5916\u8f6c\u5f55\uff09\u8fc7\u7a0b\u4e2d\u7684\u5fae\u5c0f\u5dee\u5f02\u4e5f\u53ef\u80fd\u5f71\u54cdDNA\u6b8b\u7559\u6c34\u5e73\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u8f89\u745e\/BioNTech\u75ab\u82d7\u7684DNase\u5904\u7406\u6b65\u9aa4\u66fe\u5728\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u6279\u51c6\u65f6\u88ab\u5efa\u8bae\u52a0\u5f3a\u5176\u7a33\u5065\u6027 [\u5f15\u752834]\u3002\u7136\u800c\uff0c\u5fb7\u56fd\u901a\u8fc7\u4fe1\u606f\u516c\u5f00\u6cd5\uff08FOIA\uff09\u83b7\u5f97\u7684\u6587\u4ef6\u663e\u793a\uff0c\u5728\u6388\u674315\u4e2a\u6708\u540e\uff0c\u8f89\u745e\/BioNTech\u7684\u591a\u4e2a\u751f\u4ea7\u57fa\u5730\u4ecd\u5b58\u5728DNA\u6b8b\u7559\u6c34\u5e73\u4e0d\u4e00\u81f4\u7684\u95ee\u9898\uff0c\u5305\u62ec\u4f7f\u7528\u5185\u90e8\u201c\u6807\u51c6\u201d\u4ee5\u53caDNase\u9176\u6d3b\u6027\u4e0eDNA\u6b8b\u7559\u4e4b\u95f4\u7f3a\u4e4f\u5173\u8054\u6027\u3002\u8fd9\u8868\u660e\u53bb\u9664DNA\u7247\u6bb5\u7684\u52aa\u529b\u4ecd\u672a\u53d6\u5f97\u7406\u60f3\u6210\u6548\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u6211\u4eec\u5bf9\u6b8b\u7559DNA\u542b\u91cf\u4e0eVAERS\u7cfb\u7edf\u4e2dSAE\u62a5\u544a\u4e4b\u95f4\u5173\u7cfb\u7684\u63a2\u7d22\u6027\u5206\u6790\u5c1a\u5c5e\u521d\u6b65\uff0c\u6837\u672c\u91cf\u6709\u9650\uff0c\u4f46\u503c\u5f97\u901a\u8fc7\u66f4\u591a\u6279\u6b21\u548c\u75ab\u82d7\u74f6\u8fdb\u884c\u9a8c\u8bc1\u3002\u521d\u6b65\u7ed3\u679c\u663e\u793a\uff0c\u5c24\u5176\u5728ori\u5e8f\u5217\u65b9\u9762\uff0c\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a\u6570\u91cf\u4e0eDNA\u6c34\u5e73\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u76f8\u5173\u6027\u3002\u9700\u8981\u5176\u4ed6\u72ec\u7acb\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u66f4\u591a\u68c0\u6d4b\uff0c\u5e76\u5f00\u5c55\u524d\u77bb\u6027\u957f\u671f\u76d1\u6d4b\u4ee5\u786e\u8ba4\u7ed3\u679c\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u5728qPCR\u68c0\u6d4b\u4e2d\uff0c\u8f89\u745e\u6279\u6b21FD0810\uff08\u6240\u68c0\u6d4b\u7684\u6700\u65e9\u6279\u6b21\uff09\u663e\u793aspike\u548cSV40\u5e8f\u5217\u542b\u91cf\u8f83\u4f4e\uff0cori\u5e8f\u5217\u4e0e\u5176\u4ed6\u7d2b\u76d6\u6210\u4eba\u75ab\u82d7\u76f8\u5f53\uff0c\u4f46\u5374\u4e0eVAERS\u4e2d\u62a5\u544a\u7684\u6700\u9ad8AE\u603b\u6570\u76f8\u5173\u3002\u7531\u4e8e\u4ec5\u68c0\u6d4b\u4e86\u4e00\u4e2a\u74f6\u5b50\uff0c\u53ef\u80fd\u65e0\u6cd5\u4ee3\u8868\u6574\u4e2a\u6279\u6b21\u3002\u82e5\u4e0d\u6e05\u695a\u6bcf\u6279\u6b21\u7684\u89c4\u6a21\u6216\u63a5\u79cd\u4eba\u6570\uff0c\u4ec5\u51ed16\u4e2a\u6279\u6b21\u7684\u6570\u636e\u96be\u4ee5\u5efa\u7acbSAE\u4e0e\u6279\u6b21\u4e4b\u95f4\u7684\u660e\u786e\u5173\u8054\u3002\u5982\u679c\u67d0\u6279\u6b21\u63a5\u79cd\u4eba\u6570\u8fdc\u9ad8\u4e8e\u5176\u4ed6\u6279\u6b21\uff0c\u5219\u53ef\u80fd\u626d\u66f2SAE\/\u4eba\u6bd4\u7387\uff0c\u8fdb\u4e00\u6b65\u589e\u52a0\u5206\u6790\u96be\u5ea6\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u7136\u800c\uff0c\u6211\u4eec\u7684\u53d1\u73b0\u8868\u660e\uff0c\u9664\u4e86\u8d28\u7c92DNA\u6c34\u5e73\u5916\uff0cLNP\u7ed3\u6784\u3001\u6bd2\u6027\u3001\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u6216\u6838\u7cd6\u4f53\u79fb\u7801\u5f15\u53d1\u7684\u5f02\u5e38\u514d\u75ab\u53cd\u5e94\u4e5f\u53ef\u80fd\u5bfc\u81f4\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5305\u62ec\u8865\u4f53\u6fc0\u6d3b\u76f8\u5173\u4f2a\u8fc7\u654f\u53cd\u5e94\uff08CARPA\uff09\u3002\u75ab\u82d7\u74f6\u4e2dDNA\u7247\u6bb5\u7684\u968f\u673a\u7ec4\u6210\u4f7f\u5f97DNA\u6c34\u5e73\u4e0e\u7279\u5b9a\u4e0d\u826f\u53cd\u5e94\u4e4b\u95f4\u7684\u76f4\u63a5\u5173\u8054\u53d8\u5f97\u590d\u6742\uff0c\u56e0\u4e3a\u6bcf\u4e2a\u7247\u6bb5\u7684\u57fa\u56e0\u6bd2\u6027\u6548\u5e94\u53d6\u51b3\u4e8e\u5176\u5e8f\u5217\u53ca\u4e0e\u5bbf\u4e3b\u57fa\u56e0\u7ec4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5177\u6709\u4e0d\u53ef\u9884\u6d4b\u6027\u3002\u8fd9\u79cd\u53d8\u5f02\u6027\u4f7f\u5f97\u4ec5\u51edDNA\u6570\u91cf\u96be\u4ee5\u51c6\u786e\u4f30\u7b97\u4e0d\u826f\u53cd\u5e94\u98ce\u9669\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u66f4\u9ad8\u7684DNA\u8d1f\u8f7d\u4e5f\u53ef\u80fd\u5e26\u6765\u957f\u671f\u5065\u5eb7\u98ce\u9669\uff0c\u4f8b\u5982\u901a\u8fc7\u57fa\u56e0\u7ec4\u6574\u5408\u4e8b\u4ef6\u8bf1\u53d1\u764c\u75c7\u3002VAERS\u4e3b\u8981\u8bb0\u5f55\u77ed\u671f\u4e0d\u826f\u4e8b\u4ef6\uff0c\u53ef\u80fd\u4f4e\u4f30\u4e86\u957f\u671f\u5f71\u54cd\u3002\u9700\u8981\u8fdb\u4e00\u6b65\u68c0\u6d4b\u75ab\u82d7\u74f6\uff0c\u4ee5\u5efa\u7acb\u57fa\u4e8eVAERS\u6570\u636e\u7684\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u3002\u957f\u671f\u524d\u77bb\u6027\u76d1\u6d4b\u5bf9\u4e8e\u8bc4\u4f30\u57fa\u56e0\u75ab\u82d7\u7684\u5f71\u54cd\u81f3\u5173\u91cd\u8981\uff0c\u5c24\u5176\u662f\u5728\u5df2\u68c0\u6d4b\u5230\u75ab\u82d7\u63a5\u79cd\u540e\u6700\u957f\u8fbe704\u5929\u4ecd\u5b58\u5728spike\u86cb\u767d\uff08\u523a\u7a81\u86cb\u767d\uff09\u7684\u60c5\u51b5\u4e0b\u3002<img decoding=\"async\" title=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c8\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c8\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/VHHCQQWicLYKoRdC0phibB0feWF1rEJLVqV8ONOVhCl2KPvC4Mt0IvzSIXYUYuDqNxhqFiaMu8kV0JbHOkHE7XoOg\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1&amp;watermark=1#imgIndex=4\" \/><img decoding=\"async\" title=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c9\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c9\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/VHHCQQWicLYKoRdC0phibB0feWF1rEJLVqV8ONOVhCl2KPvC4Mt0IvzSIXYUYuDqNxhqFiaMu8kV0JbHOkHE7XoOg\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1&amp;watermark=1#imgIndex=4\"><\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>Moderna\u4e0ePfizer\u75ab\u82d7\u6279\u6b21\u4e4b\u95f4\u7684\u6b8b\u7559DNA\u5dee\u5f02\uff1a<\/strong>\u00a0 \u7814\u7a76\u53d1\u73b0\uff0cModerna\u75ab\u82d7\u6279\u6b21\u5728qPCR\u68c0\u6d4b\u548c\u8367\u5149\u6cd5\uff08fluorometry\uff09\u4f30\u7b97\u6b8b\u7559DNA\u65b9\u9762\u5448\u73b0\u4e0d\u540c\u7684\u5173\u7cfb\u3002\u8fd9\u4e9b\u5dee\u5f02\u53ef\u80fd\u6e90\u4e8e\u4e24\u79cd\u75ab\u82d7\u5728\u5242\u91cf\u4f53\u79ef\u3001DNA\u6570\u91cf\u3001DNA\u7247\u6bb5\u5927\u5c0f\u5206\u5e03\u3001\u8d28\u7c92\u8f7d\u4f53\u5e8f\u5217\u7ec4\u6210\u4ee5\u53ca\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08LNP\uff09\u6210\u5206\u4e0a\u7684\u4e0d\u540c\u3002\u6b64\u5916\uff0c\u4e0d\u540c\u6279\u6b21\u4e4b\u95f4\u7684\u6742\u8d28\u6216\u6c61\u67d3\u7269\u6c34\u5e73\u4e5f\u53ef\u80fd\u5f71\u54cd\u7ed3\u679c\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u6f5c\u5728\u6c61\u67d3\u7269\u4e0e\u6bd2\u7406\u673a\u5236\uff1a<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u788e\u7247\u5316mRNA<\/strong>\uff1a\u53ef\u80fd\u5f71\u54cd\u5faeRNA\uff08miRNA\uff09\u8fc7\u7a0b\uff0c\u5177\u6709\u6f5c\u5728\u6bd2\u6027\u3002<\/li>\n<li><strong>\u53cc\u94feRNA\uff08dsRNA\uff09<\/strong>\uff1a\u7531T7 RNA\u805a\u5408\u9176\u542f\u52a8\u5b50\u5f15\u8d77\uff0c\u53ef\u8bf1\u5bfc\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff0c\u53ef\u80fd\u4e0e\u5fc3\u808c\u708e\u7b49\u514d\u75ab\u708e\u75c7\u53cd\u5e94\u76f8\u5173\u3002<\/li>\n<li><strong>\u8102\u591a\u7cd6\uff08LPS\uff09<\/strong>\uff1a\u53ef\u4e0e\u523a\u7a81\u86cb\u767d\u7684S1\u548cS2\u4e9a\u5355\u4f4d\u7ed3\u5408\uff0c\u589e\u5f3a\u708e\u75c7\u53cd\u5e94\u3002<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\u4e0e\u75ab\u82d7\u6279\u6b21\u7684\u5173\u8054\uff1a<\/strong>\u00a0 \u66f4\u5e7f\u6cdb\u7684\u6837\u672c\u91c7\u96c6\u53ef\u80fd\u63ed\u793a\u66f4\u591a\u4e0d\u826f\u4e8b\u4ef6\u7c7b\u578b\uff08\u5982\u6b7b\u4ea1\uff09\u4e0e\u75ab\u82d7\u6279\u6b21\u7684\u5173\u8054\u3002\u5c3d\u7ba1\u76ee\u524d\u7814\u7a76\u7684\u6279\u6b21\u672a\u5305\u542b\u5728Schmeling\u7b49\u4eba\u7684\u7814\u7a76\u4e2d\uff0c\u4f46\u4ecd\u9700\u8fdb\u4e00\u6b65\u63a2\u8ba8DNA\u6c61\u67d3\u4e0e\u4e0d\u826f\u4e8b\u4ef6\u4e4b\u95f4\u7684\u6f5c\u5728\u5173\u7cfb\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>SV40\u589e\u5f3a\u5b50\u4e0e\u57fa\u56e0\u6574\u5408\u98ce\u9669\uff1a<\/strong>\u00a0 \u867d\u7136SV40\u589e\u5f3a\u5b50\u53ef\u4fc3\u8fdb\u6838\u5b9a\u4f4d\uff0c\u4f46\u5c1a\u672a\u8bc1\u5b9eCOVID-19 modRNA\u75ab\u82d7\u4e2dDNA\u7247\u6bb5\u7684\u57fa\u56e0\u7ec4\u6574\u5408\u3002\u7136\u800c\uff0cDNA\u6c61\u67d3\u53ef\u80fd\u6fc0\u6d3b\u5148\u5929\u514d\u75ab\u53cd\u5e94\uff0c\u5177\u6709\u4fc3\u8840\u6813\u548c\u4fc3\u764c\u98ce\u9669\uff0c\u5c24\u5176\u662fGC\u542b\u91cf\u9ad8\u7684\u7247\u6bb5\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>qPCR\u4e0e\u8367\u5149\u6cd5\u7684\u5c40\u9650\u6027\u4e0e\u504f\u5dee\uff1a<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>qPCR\u65e0\u6cd5\u68c0\u6d4b\u5c0f\u4e8e\u6269\u589e\u7247\u6bb5\uff08105\u2013114 bp\uff09\u7684DNA\uff0c\u53ef\u80fd\u4f4e\u4f30\u603b\u6b8b\u7559\u91cf\u3002<\/li>\n<li>\u4f7f\u7528\u5355\u4e00\u6269\u589e\u5b50\u53ef\u80fd\u5bfc\u81f4\u4f30\u7b97\u504f\u5dee\u9ad8\u8fbe100\u500d\u3002<\/li>\n<li>Moderna\u75ab\u82d7\u4e2d\u523a\u7a81DNA\u7684\u542b\u91cf\u8fdc\u9ad8\u4e8e\u975e\u523a\u7a81DNA\uff0c\u6697\u793aDNase I\u9176\u5728RNA\u4e92\u8865\u533a\u57df\u7684\u964d\u89e3\u6548\u7387\u53d7\u9650\u3002<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u8367\u5149\u6cd5\u7684\u8bef\u5dee\u6765\u6e90\u4e0e\u6539\u8fdb\u5efa\u8bae\uff1a<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>\u9ad8RNA\u6d53\u5ea6\u53ef\u80fd\u5e72\u6270DNA\u7279\u5f02\u6027\u67d3\u6599\uff0c\u5bfc\u81f4DNA\u542b\u91cf\u9ad8\u4f30\u3002<\/li>\n<li>\u51b7\u51bb-\u89e3\u51bb\u5faa\u73af\u3001\u6837\u672c\u5904\u7406\u8bef\u5dee\u4e5f\u4f1a\u5f71\u54cd\u6d4b\u91cf\u7ed3\u679c\u3002<\/li>\n<li>\u5efa\u8bae\u7ed3\u5408RNase A\u5904\u7406\u4ee5\u53bb\u9664modRNA\uff0c\u63d0\u9ad8DNA\u5b9a\u91cf\u51c6\u786e\u6027\u3002<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/wxa.wxs.qq.com\/tmpl\/mw\/base_tmpl.html\">https:\/\/wxa.wxs.qq.com\/tmpl\/mw\/base_tmpl.html<\/a><\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u6d4b\u91cf\u65b9\u6cd5\u5bf9\u7ed3\u679c\u7684\u5f71\u54cd\uff1a<\/strong>\u00a0 Pfizer\u75ab\u82d7\u4f7f\u7528\u8367\u5149\u6cd5\u548c\u7d2b\u5916\u5149\u8c31\u6cd5\u6d4b\u91cfRNA\uff0cqPCR\u6d4b\u91cfDNA\u3002\u8fd9\u79cd\u9009\u62e9\u6027\u4f7f\u7528\u4e0d\u540c\u65b9\u6cd5\u53ef\u80fd\u5bfc\u81f4RNA\/DNA\u6bd4\u4f8b\u4f30\u7b97\u5dee\u5f02\u663e\u8457\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u6d4b\u5e8f\u4e0eDNA\u7247\u6bb5\u504f\u5dee\uff1a<\/strong>\u00a0 Oxford Nanopore\u6d4b\u5e8f\uff08ONT\uff09\u504f\u5411\u68c0\u6d4b\u5927\u4e8e150 bp\u7684\u7247\u6bb5\uff0c\u53ef\u80fd\u4f4e\u4f30\u5c0f\u7247\u6bb5DNA\u7684\u5b58\u5728\u3002\u5e38\u89c4DNA\u7eaf\u5316\u65b9\u6cd5\u4e5f\u5bb9\u6613\u4e22\u5931\u5c0f\u4e8e100 bp\u7684\u7247\u6bb5\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u76d1\u7ba1\u6807\u51c6\u4e0e\u91cd\u65b0\u8bc4\u4f30\u7684\u5fc5\u8981\u6027\uff1a<\/strong>\u00a0 FDA\u76ee\u524d\u89c4\u5b9a\u75ab\u82d7\u4e2d\u6b8b\u7559DNA\u5e94\u4f4e\u4e8e10 ng\/\u5242\u91cf\uff0c\u4e14DNA\u7247\u6bb5\u5c0f\u4e8e\u529f\u80fd\u57fa\u56e0\uff08\u7ea6200 bp\uff09\u3002\u8fd9\u4e9b\u6807\u51c6\u9002\u7528\u4e8e\u201c\u88f8\u9732\u201dDNA\uff0c\u4f46\u7531\u4e8emodRNA\u75ab\u82d7\u4e2dDNA\u88abLNP\u5305\u88f9\u5e76\u9ad8\u6548\u8f6c\u67d3\u7ec6\u80de\uff0c\u73b0\u884c\u6807\u51c6\u53ef\u80fd\u9700\u8981\u91cd\u65b0\u8bc4\u4f30\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>FDA\u4e0eWHO\u5173\u4e8e\u75ab\u82d7\u4e2d\u6b8b\u7559DNA\u7684\u6307\u5bfc\u539f\u5219\uff1a<\/strong><\/p>\n<p class=\"wp-block-paragraph\">FDA\u548cWHO\u5bf9\u75ab\u82d7\u4e2d\u53ef\u63a5\u53d7DNA\u6b8b\u7559\u91cf\u7684\u6307\u5bfc\u539f\u5219\u53d7\u5230FDA\u79d1\u5b66\u5bb6Sheng-Fowler\u7b49\u4eba\u7814\u7a76\u7684\u5f71\u54cd\u3002\u8be5\u7814\u7a76\u5173\u6ce8\u5bbf\u4e3b\u7ec6\u80de\u57fa\u56e0\u7ec4DNA\u7684\u6c61\u67d3\uff0c\u5e76\u6307\u51fa\u5f53\u6c61\u67d3\u7269\u662f\u5c0f\u578b\u75c5\u6bd2\u8f7d\u4f53\u65f6\uff0c\u6bcf\u7eb3\u514bDNA\u4e2d\u5206\u5b50\u6570\u91cf\u663e\u8457\u589e\u52a0\u3002\u5728\u8fd9\u79cd\u9ad8\u62f7\u8d1d\u6c61\u67d3\u7269\u7684\u60c5\u51b5\u4e0b\uff0c\u6781\u5fae\u91cf\uff08\u98de\u514b\u7ea7\u81f3\u963f\u514b\u7ea7\uff09\u7684DNA\u53ef\u80fd\u7b49\u540c\u4e8e\u7eb3\u514b\u7ea7\u5bbf\u4e3b\u7ec6\u80deDNA\u3002\u7531\u4e8emodRNA\u75ab\u82d7\u4e2d\u7684DNA\u7247\u6bb5\u8f83\u77ed\uff0c\u6bcf\u5242\u75ab\u82d7\u4e2d\u7684DNA\u5206\u5b50\u6570\u91cf\u53ef\u80fd\u8d85\u8fc71000\u4ebf\u4e2a\u3002\u8fd9\u4e9b\u6b8b\u7559DNA\u5177\u6709\u9ad8\u62f7\u8d1d\u6570\uff0c\u5bcc\u542b\u542f\u52a8\u5b50\u3001SV40\u54fa\u4e73\u52a8\u7269\u590d\u5236\u8d77\u59cb\u70b9\u3001\u5f00\u653e\u9605\u8bfb\u6846\uff08ORFs\uff09\u4ee5\u53ca\u6838\u5b9a\u4f4d\u5e8f\u5217\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08LNP\uff09\u5305\u88c5\u7684\u5f71\u54cd\uff1a<\/strong><\/p>\n<p class=\"wp-block-paragraph\">FDA\u548cWHO\u7684\u6307\u5bfc\u539f\u5219\u672a\u8003\u8651DNA\u88ab\u5305\u88c5\u5728\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\u4e2d\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4DNA\u5728\u4f53\u5185\u5b58\u7559\u65f6\u95f4\u66f4\u957f\uff0c\u5e76\u63d0\u9ad8\u8f6c\u67d3\u6548\u7387\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u6307\u5bfc\u539f\u5219\u4e5f\u672a\u8003\u8651\u4f7f\u7528LNP\u5e73\u53f0\u8fdb\u884cmodRNA\u75ab\u82d7\u7684\u7d2f\u79ef\u63a5\u79cd\u98ce\u9669\u3002\u7814\u7a76\u8868\u660e\uff0cLNP\u53ef\u4f7fRNA\u6216DNA\u8fdb\u5165\u7ec6\u80de\u7684\u6548\u7387\u63d0\u9ad810\u81f3100\u500d\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u65e5\u672c\u7684\u75ab\u82d7\u63a5\u79cd\u60c5\u51b5\u4e0e\u7d2f\u79ef\u98ce\u9669\uff1a<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u5728\u65e5\u672c\uff0c\u670913%\u7684\u4eba\u53e3\u63a5\u79cd\u4e86\u4e03\u5242COVID-19\u75ab\u82d7\uff0c\u4e14\u52a0\u5f3a\u9488\u95f4\u9694\u65f6\u95f4\u6709\u65f6\u77ed\u81f3\u4e24\u4e2a\u6708\u3002\u6b64\u5916\uff0c\u9488\u5bf9\u5176\u4ed6\u611f\u67d3\u7684\u75ab\u82d7\u82e5\u91c7\u7528\u76f8\u540c\u7684\u8d28\u7c92\u548cLNP\u5e73\u53f0\uff0c\u5176\u7d2f\u79ef\u63a5\u79cd\u98ce\u9669\u5728\u5236\u5b9a\u6b8b\u7559DNA\u6307\u5bfc\u539f\u5219\u65f6\u4e5f\u672a\u88ab\u8003\u8651\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>DNA\u7247\u6bb5\u957f\u5ea6\u4e0e\u6574\u5408\u98ce\u9669\uff1a<\/strong>FDA\u7684\u6307\u5bfc\u539f\u5219\u4ec5\u5bf9\u957f\u5ea6\u5927\u4e8e200\u78b1\u57fa\u5bf9\u7684DNA\u7247\u6bb5\u8fdb\u884c\u5b9a\u91cf\uff0c\u90e8\u5206\u539f\u56e0\u662f\u8ba4\u4e3a\u77ed\u4e8e\u6b64\u957f\u5ea6\u7684\u7247\u6bb5\u65e0\u6cd5\u5f62\u6210\u529f\u80fd\u6027\u57fa\u56e0\u3002\u7136\u800c\uff0cKlinman\u7b49\u4eba\u6307\u51fa\uff0c\u77ed\u81f37\u78b1\u57fa\u5bf9\u7684DNA\u7247\u6bb5\u4e5f\u53ef\u80fd\u5b58\u5728\u6574\u5408\u98ce\u9669\u3002\u6b64\u5916\uff0c\u6307\u5bfc\u539f\u5219\u53ef\u80fd\u5047\u8bbe\u77ed\u7247\u6bb5\u88f8\u9732DNA\u66f4\u5bb9\u6613\u88ab\u5bbf\u4e3b\u6838\u9178\u9176\u964d\u89e3\uff0c\u4f46\u8fd9\u79cd\u5047\u8bbe\u4e0d\u9002\u7528\u4e8e\u88abLNP\u4fdd\u62a4\u7684\u75ab\u82d7DNA\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u529f\u80fd\u6027DNA\u7247\u6bb5\u7684\u6f5c\u5728\u5371\u5bb3\uff1a<\/strong>Klinman\u7b49\u4eba\u8fd8\u6307\u51fa\uff1a\u201c\u5728\u8bc4\u4f30\u8d28\u7c92\u6574\u5408\u7684\u6f5c\u5728\u5371\u5bb3\u65f6\uff0c\u5e94\u6ce8\u610f\u5c06\u5177\u6709\u5f3a\u8c03\u63a7\u533a\u57df\u7684\u8d28\u7c92\u5f15\u5165\u5bbf\u4e3b\u57fa\u56e0\u7ec4\u7684\u98ce\u9669\u8fdc\u9ad8\u4e8e\u968f\u673a\u70b9\u7a81\u53d8\u3002\u201d<\/p>\n<p class=\"wp-block-paragraph\"><strong>SV40\u5e8f\u5217\u7684\u529f\u80fd\u6027\u4e0e\u6f5c\u5728\u98ce\u9669\uff1a<\/strong>\u73b0\u884c\u6307\u5bfc\u539f\u5219\u672a\u8003\u8651\u6b8b\u7559DNA\u662f\u5426\u5305\u542b\u6838\u5b9a\u4f4d\u5e8f\u5217\u3001\u54fa\u4e73\u52a8\u7269\u590d\u5236\u8d77\u59cb\u70b9\u548c\u542f\u52a8\u5b50\u7b49\u529f\u80fd\u6027\u5143\u4ef6\uff0c\u800c\u8fd9\u4e9b\u5728Pfizer\u75ab\u82d7\u4e2d\u786e\u5b9e\u5b58\u5728\u3002Vacik\u7b49\u4eba\u8bc1\u660e\uff0cPfizer\u8f7d\u4f53\u4e2d\u7684SV40\u589e\u5f3a\u5b50\u662f\u4e00\u79cd\u5f3a\u6548\u6838\u5b9a\u4f4d\u5e8f\u5217\uff0c\u5728\u57fa\u56e0\u6cbb\u7597\u4e2d\u5177\u6709\u6f5c\u529b\u3002Senigl\u7b49\u4eba\u6307\u51fa\uff0cSV40\u589e\u5f3a\u5b50\u662f\u5177\u6709\u81f4\u7624\u6f5c\u529b\u7684\u4f53\u7ec6\u80de\u9ad8\u7a81\u53d8\u5143\u4ef6\u3002Drayman\u7b49\u4eba\u5219\u53d1\u73b0\uff0cPfizer\u75ab\u82d7\u4e2d\u7684SV40\u589e\u5f3a\u5b50\u53ef\u4e0eP53\u7ed3\u5408\uff0c\u63d0\u793a\u6211\u4eec\u5e94\u91cd\u65b0\u5ba1\u89c6\u6b8b\u7559DNA\u7684\u7eb3\u514b\u7ea7\u9650\u503c\uff0c\u5c24\u5176\u662f\u8003\u8651\u5176\u529f\u80fd\u6027\u4e0e\u590d\u5236\u80fd\u529b\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u7ed3\u8bba<\/strong>: \u672c\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u5728\u6240\u68c0\u6d4b\u7684modRNA\u65b0\u51a0\u75ab\u82d7\u4e2d\uff0c\u6bcf\u5242\u542b\u6709\u6570\u5341\u4ebf\u81f3\u6570\u5343\u4ebf\u4e2aDNA\u5206\u5b50\u3002\u901a\u8fc7\u8367\u5149\u6cd5\u7ed3\u5408RNase A\u6d88\u5316\u5904\u7406\uff0c\u6240\u6709\u6837\u672c\u7684\u6b8b\u7559DNA\u542b\u91cf\u5747\u8fdc\u8d85\u7f8e\u56fdFDA\u4e0e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08WHO\uff09\u8bbe\u5b9a\u7684\u6bcf\u524210\u7eb3\u514b\u7684\u5b89\u5168\u4e0a\u9650\uff0c\u8d85\u6807\u5e45\u5ea6\u8fbe36\u81f3627\u500d\u3002<\/p>\n<p class=\"wp-block-paragraph\">qPCR\u68c0\u6d4b\u7ed3\u679c\u663e\u793a\uff0c\u6240\u6709\u83ab\u5fb7\u7eb3\u75ab\u82d7\u74f6\u5747\u5728\u76d1\u7ba1\u9650\u503c\u4e4b\u5185\uff0c\u800c\u8f89\u745e\u75ab\u82d7\u4e2d\u67093\u74f6\u6837\u672c\u7684SV40\u542f\u52a8\u5b50-\u589e\u5f3a\u5b50-\u590d\u5236\u8d77\u59cb\u5e8f\u5217\uff08SV40 promoter-enhancer-ori\uff09\u8d85\u51fa\u9650\u503c\uff0c\u5e76\u8868\u73b0\u51fa\u663e\u8457\u7684\u6279\u6b21\u5185\u4e0e\u6279\u6b21\u95f4\u5dee\u5f02\u3002\u7531\u4e8eqPCR\u5bf9\u4e0d\u540c\u57fa\u56e0\u9776\u70b9\u7684\u68c0\u6d4b\u7ed3\u679c\u5dee\u5f02\u8f83\u5927\uff0c\u53ef\u80fd\u4f4e\u4f30\u603bDNA\u542b\u91cf\uff0c\u56e0\u6b64\u5f3a\u8c03\u5e94\u91c7\u7528\u591a\u79cd\u68c0\u6d4b\u65b9\u6cd5\u4ee5\u51c6\u786e\u8bc4\u4f30DNA\u8d1f\u8f7d\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u76d1\u7ba1\u673a\u6784\u4e9f\u9700\u5236\u5b9a\u6e05\u6670\u4e00\u81f4\u7684\u6807\u51c6\uff0c\u7528\u4e8e\u91cf\u5316modRNA\u75ab\u82d7\u4e2d\u7684mRNA\u4e0e\u8d28\u7c92DNA\u3002\u6700\u65b0\u7684XBB.1.5\u7248\u672c\u83ab\u5fb7\u7eb3\u4e0e\u8f89\u745e\u75ab\u82d7\u7684PCR\u7ed3\u679c\u8868\u660e\uff0c\u5176DNA\u6b8b\u7559\u6c34\u5e73\u5e76\u672a\u8f83\u65e9\u671f\u7248\u672c\u6709\u6240\u964d\u4f4e\u3002<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u6211\u4eec\u7684\u7814\u7a76\u8fdb\u4e00\u6b65\u52a0\u6df1\u4e86\u5bf9\u75ab\u82d7\u5b89\u5168\u6027\u7684\u62c5\u5fe7\uff0c\u5e76\u8d28\u7591\u73b0\u884c\u76d1\u7ba1\u6807\u51c6\u662f\u5426\u4ecd\u9002\u7528\u4e8e\u91c7\u7528\u9ad8\u6548LNP\u8f6c\u67d3\u6280\u672f\u7684\u65b0\u578b\u75ab\u82d7\u3002\u5c3d\u7ba1\u672c\u7814\u7a76\u5b58\u5728\u82e5\u5e72\u5c40\u9650\uff0c\u6211\u4eec\u4ecd\u547c\u5401\u5728\u6cd5\u533b\u5b66\u6761\u4ef6\u4e0b\u91cd\u590d\u9a8c\u8bc1\u672c\u7814\u7a76\u7ed3\u679c\uff0c\u5e76\u4fee\u8ba2\u76f8\u5173\u6807\u51c6\uff0c\u4ee5\u5145\u5206\u8003\u8651\u9ad8\u6548DNA\u8f6c\u67d3\u4e0e\u7d2f\u79ef\u63a5\u79cd\u7684\u6f5c\u5728\u5f71\u54cd\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u5f3a\u8c03\uff0c\u76d1\u7ba1\u673a\u6784\u4e0e\u75ab\u82d7\u5236\u9020\u5546\u5e94\u9075\u5faa\u201c\u9884\u9632\u539f\u5219\u201d\uff0c\u63d0\u4f9b\u5145\u5206\u4e14\u900f\u660e\u7684\u8bc1\u636e\uff0c\u8bc1\u660e\u4ea7\u54c1\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\uff0c\u5e76\u516c\u5f00\u5176\u6210\u5206\u6784\u6210\u4e0e\u751f\u4ea7\u5de5\u827a\u7684\u8be6\u7ec6\u4fe1\u606f\u3002<\/p>\n<p class=\"wp-block-paragraph\"><em>\uff08\u53c2\u8003\u8bba\u658765\u7bc7\uff0c\u6b64\u5904\u7565\uff09\u8bba\u6587\u81ea<\/em><em>www.tandfonline.com<\/em><img decoding=\"async\" title=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c10\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" 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\u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u540c\u884c\u8bc4\u5ba1\u7814\u7a76\u8b66\u544a\uff1a\u8f89\u745e\u4e0e\u83ab\u5fb7\u7eb3\u75ab\u82d7\u6b8b\u7559DNA\u8fdc\u8d85\u5b89\u5168\u4e0a\u9650\uff0cSV40\u5e8f\u5217\u5f15\u53d1\u4e89\u8bae - \u7b2c11\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/VHHCQQWicLYKoRdC0phibB0feWF1rEJLVqGf4kmt9OQClMWBhWl7VNKwSYqAxp8SRKBQGkIc5ibNJrldkgKIiaYTeQ\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1&amp;watermark=1#imgIndex=5\"><\/p>\n<p class=\"wp-block-paragraph\"><strong>\u4ee5\u4e0b\u540c\u7c7b\u76f8\u5173\u6587\u7ae0\uff1a<\/strong><\/p>\n<p class=\"wp-block-paragraph\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247503060&amp;idx=1&amp;sn=1d201b2e2b74d414f3328487cdc23c67&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\"><strong>\u5ddd\u666e\u653f\u5e9c\u8003\u8651\u5168\u9762\u7981\u7528mRNA\u75ab\u82d7\uff0c\u5f15\u53d1\u533b\u5b66\u754c\u9707\u8361<\/strong><\/a><\/p>\n<p class=\"wp-block-paragraph\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247503633&amp;idx=1&amp;sn=eb7a9013b8a85927df2229865c135218&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\"><strong>\u5ddd\u666e\u603b\u7edf\u8d28\u95ee\u75ab\u82d7\u98ce\u9669\uff1a\u522b\u518d\u9690\u7792\uff01<\/strong><\/a><\/p>\n<p class=\"wp-block-paragraph\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247503486&amp;idx=2&amp;sn=02b2bb1bd8e0d9e358ed977b377393d7&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\"><strong>\u7a81\u7834\u6027\u7814\u7a76\uff1amRNA\u75ab\u82d7\u4e0eSARS-CoV-2\u534f\u540c\u63a8\u52a8\u5168\u7403\u8d85\u989d\u6b7b\u4ea1\u548c\u75be\u75c5<\/strong><\/a><\/p>\n<p class=\"wp-block-paragraph\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247503417&amp;idx=1&amp;sn=ad72fbc1bd96893764af85c689f82c7f&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\"><strong>\u4ee4\u4eba\u9707\u60ca\u7684\u65b0\u51a0\u75c5\u6bd2Vaccine\u707e\u96be\u6570\u636e<\/strong><\/a><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247502370&amp;idx=1&amp;sn=e4857f6056adc17ad4e266f90813e492&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u4e16\u536b\u7ec4\u7ec7\uff1a\u201c\u7334\u75d8\u201d\u662fCovid mRNA\u201c\u75ab\u82d7\u201d\u7684\u526f\u4f5c\u7528<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247502451&amp;idx=1&amp;sn=99e26152e38858e7dcd8759320aedb46&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u5bf9 8500 \u4e07\u4eba\u7684\u7814\u7a76\u8bc1\u5b9e\uff0cCovid \u201c\u75ab\u82d7 \u201d\u5bfc\u81f4\u5168\u7403\u8111\u6897\u3001\u5fc3\u810f\u75c5\u53d1\u4f5c\u548c\u731d\u6b7b\u4eba\u6570\u6fc0\u589e<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247502161&amp;idx=1&amp;sn=8d8a8a88c5c4995c39ef1521fe513692&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u94c1\u8bc1\u5982\u5c71\uff1a\u5bf9 9,900 \u4e07\u4eba\u7684\u7814\u7a76\u8bc1\u5b9e\uff0cCovid \u201c\u75ab\u82d7 \u201d\u5bfc\u81f4\u5168\u7403\u6b7b\u4ea1\u4eba\u6570\u6fc0\u589e<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247502114&amp;idx=1&amp;sn=8e08a8dff07b1bf74cab64cdca22b617&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u4e0d\u53ef\u601d\u8bae\uff1a\u5fb7\u56fd\u8bc1\u5b9emRNA\u201c\u75ab\u82d7\u201d\u6bd4Covid\u5bb3\u6b7b\u7684\u4eba\u66f4\u591a<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247502090&amp;idx=1&amp;sn=bc35e29f6d7930fd4b37be54e66d7b77&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u4ee4\u4eba\u4f5c\u5455\u7684\u4e8b\u5b9e\uff1a\u52a0\u62ff\u5927\u627f\u8ba4\u65b0\u51a0\u75ab\u82d7\u52a0\u5f3a\u9488\u5bfc\u81f4\u6b7b\u4ea1\u7387\u6fc0\u589e<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247502082&amp;idx=1&amp;sn=eab7a0e4ba3247879962b4c91503f4c8&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u9876\u7ea7\u533b\u751f\u8b66\u544a\uff1a\u65b0\u51a0\u75ab\u82d7\u201c\u52a0\u5f3a\u9488\u201d\u6216\u6fc0\u6d3b\u81f4\u547d\u7ed3\u6838\u75c5<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247502067&amp;idx=1&amp;sn=a3cd7b259ef7e4bb719ce81a1d8272c8&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u5370\u5ea6\u53d1\u5e03\u7d27\u6025\u8b66\u544a\uff1a\u63a5\u79cd\u75ab\u82d7\u540e\u6b7b\u4ea1\u4eba\u6570\u6fc0\u589e<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247502023&amp;idx=1&amp;sn=39b29e65e3bfdb9278b8ad6d0cf4deba&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u9876\u7ea7\u5fc3\u810f\u75c5\u4e13\u5bb6\u8b66\u544a\u6ce8\u5c04Covid\u75ab\u82d7\u8005\u5c06\u9762\u4e34 \u201c\u5fc3\u810f\u731d\u6b7b \u201d\u98ce\u9669<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247502009&amp;idx=2&amp;sn=a785d957246456409ee5df8bcc72653f&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u4fdd\u9669\u6570\u636e\u663e\u793a\uff0c\u63a5\u79cd\u8fc7Covid\u75ab\u82d7\u7684\u4eba\u5bff\u547d\u7f29\u77ed\uff0c\u6b7b\u4ea1\u7387\u98d9\u5347<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501988&amp;idx=2&amp;sn=aa8a037498c0f0732be67528bbf3f963&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\"><strong>\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u627f\u8ba4\u63a5\u79cdCovid\u75ab\u82d7\u957f\u8fbe 15 \u5e74\u6709\u8840\u6813\u98ce\u9669<\/strong><\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501967&amp;idx=1&amp;sn=de9e009d8cfd68ac028fb130f87c877d&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u8c08\u8c08\u706d\u6d3bVaccine\u548c\u523a\u7a81\u86cb\u767d\uff0c\u4e3a\u4ec0\u4e48\u8bf4\u5176\u548cmRNA\u82d7\u4e00\u6837\u6709\u5f88\u5927\u9690\u60a3\uff1f<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501962&amp;idx=1&amp;sn=f027ff12b3a0668dddf3a60956b3028a&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\"><strong>\u9707\u64bc\u7814\u7a76\uff1a\u8036\u9c81\u5927\u5b66\u79d1\u5b66\u5bb6\u8bc1\u5b9eCovid\u201c\u75ab\u82d7\u201d\u4f1a\u5f15\u53d1VAIDS<\/strong><\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501951&amp;idx=1&amp;sn=12569311b2b21308326608c3ce1845a1&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\"><strong>\u5ddd\u666e\u56e2\u961f\u6001\u5ea6\u5927\u8f6c\u53d8 &nbsp;\u7981\u6b62\u6240\u6709\u7f8e\u56fd\u4eba\u63a5\u79cd\u65b0\u51a0\u75ab\u82d7<\/strong><\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501944&amp;idx=1&amp;sn=c80cf1ab898bbe1f96233dfd0b978080&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\"><strong>\u9876\u7ea7\u80bf\u7624\u5b66\u5bb6\u8b66\u544a\u8bf4\uff0c\u63a5\u79cd\u8fc7Covid\u75ab\u82d7\u7684\u4eba\u60a3\u764c\u75c7\u7684\u6bd4\u4f8b\u5c06\u201c\u6025\u5267\u4e0a\u5347\u201d<\/strong><\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501915&amp;idx=1&amp;sn=064d86875b520006d3d1f79a5052131b&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u627f\u8ba4Covid mRNA \u201c\u75ab\u82d7 \u201d\u81f4\u764c<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501924&amp;idx=1&amp;sn=de585d5309b460d0bef33ceef1b08a75&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u5230\u5e95\u4ec0\u4e48\u662f\u957f\u65b0\u51a0\uff1f\u4ec0\u4e48\u662f\u65b0\u51a0\u540e\u9057\u75c7\uff1f\u4ec0\u4e48\u662f\u75ab\u82d7\u526f\u4f5c\u7528\uff1f<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501889&amp;idx=1&amp;sn=eabbb59cc5db4f0b619b28d8e571189e&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u5bf9900\u4e07\u4eba\u7684\u7814\u7a76\u8bc1\u5b9e \u201c\u52a0\u5f3a\u9488 \u201d\u5bfc\u81f4\u6b7b\u4ea1\u4eba\u6570\u6fc0\u589e<\/a><\/strong><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501603&amp;idx=1&amp;sn=9ed8a306830351247b37dbb61f74b522&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u9707\u60ca\uff1aFDA\u5b9e\u9a8c\u5ba4\u53d1\u73b0COVID-19\u75ab\u82d7\u4e2d\u7684DNA\u6c61\u67d3\u8d85\u6807<\/a><\/strong><br \/><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501883&amp;idx=1&amp;sn=760b4f480aa0bd54bf733d4e258a2509&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u5f97\u764c\u75c7\u7684\u4eba\u771f\u7684\u8d8a\u6765\u8d8a\u591a\u4e86\uff0c\u6ca1\u6709\u53d1\u73b0\u5417\uff1f<\/a><\/strong><br \/><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501794&amp;idx=1&amp;sn=1f8a286fe5887aaa38f26009c84dfb9f&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u6ed1\u7a3d\u4e0d\uff1f\u83ab\u5fb7\u7eb3CEO\u627f\u8ba4\u65e9\u5728\u5927\u6d41\u884c\u75c5\u524d\u5df2\u7814\u53d1\u65b0\u51a0\u75ab\u82d7<\/a><\/strong><br \/><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501769&amp;idx=1&amp;sn=5bcc4f45cda79a71537f1932f6e35db2&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u60ca\u4e0d\u60ca\u559c\uff1f\u201c\u5b89\u5168\u6709\u6548\u201d\u65b0\u51a0\u75ab\u82d7\u5c06\u5728\u5168\u7403\u88ab\u53ec\u56de<\/a><\/strong><br \/><strong><a target=\"_blank\" 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href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501531&amp;idx=1&amp;sn=a64386cc623810ac0bbbb6ae3631aff3&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u5f3a\u5927\u7684\u6570\u636e\u548c\u4e8b\u5b9e\u6765\u8bba\u8bc1\u65b0\u51a0\u75ab\u82d7\u63a5\u79cd\u8005\u548c\u672a\u63a5\u79cd\u8005\u7684\u5065\u5eb7\u5bf9\u6bd4<\/a><\/strong><em><strong>\uff08\u672c\u6587\u540e\u9762\u67092024\u5e74\u5199\u7684\u8d85\u8fc760\u7bc7\u75ab\u82d7\u76f8\u5173\u6587\u7ae0\u94fe\u63a5\uff09<\/strong><\/em><\/p>\n<p class=\"wp-block-paragraph\"><strong><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUyNjA1MTQ3Mg==&amp;mid=2247501419&amp;idx=1&amp;sn=5b3b7229570e64bc02e5d1d9f2381376&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u798f\u5947\u5c06\u96be\u9003\u7f6a\u8d23\uff1a\u65b0\u51a0\u5927\u6d41\u884c\u671f\u95f4\u72af\u4e0b\u7684\u91cd\u7f6a\u6700\u7ec8\u5fc5\u53d7\u60e9\u7f5a<\/a><\/strong><\/p>\n<p 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