{"id":67554,"date":"2026-08-20T08:00:15","date_gmt":"2026-08-20T08:00:15","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=67554"},"modified":"2026-08-20T08:00:15","modified_gmt":"2026-08-20T08:00:15","slug":"%e5%88%98%e6%b3%bd%e6%ba%90%e8%80%81%e5%b8%88-%e9%9d%92%e8%92%bf%e7%90%a5%e9%85%af%e7%89%87%e5%9c%a8%e5%81%a5%e5%ba%b7%e4%ba%ba%e4%bd%93%e4%b8%ad%e7%9a%84%e7%94%9f%e7%89%a9%e7%ad%89%e6%95%88%e6%80%a7","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=67554","title":{"rendered":"\u5218\u6cfd\u6e90\u8001\u5e08: \u9752\u84bf\u7425\u916f\u7247\u5728\u5065\u5eb7\u4eba\u4f53\u4e2d\u7684\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76"},"content":{"rendered":"

\u5218\u6cfd\u6e90\u8001\u5e08\uff1a\u9752\u84bf\u7425\u916f\u7247\u5728\u5065\u5eb7\u4eba\u4f53\u4e2d\u7684\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76 2017\u5e747\u67083\u65e5 <\/em> \u539f\u6587\u94fe\u63a5<\/strong><\/a><\/p>\n

\"\u5218\u6cfd\u6e90\u8001\u5e08:<\/figure>\n

\u00a0\u4f1a\u8bae\u5927\u5496\u00a0\u00a0<\/p>\n

\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:<\/figure>\n

\u5218\u6cfd\u6e90<\/strong>: \u4e3b\u4efb\u836f\u5e08\uff0c\u526f\u4e3b\u4efb\u533b\u5e08\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u673a\u6784\u526f\u4e3b\u4efb\u3001\u529e\u516c\u5ba4\u4e3b\u4efb\uff0c\u73b0\u4efb\u5168\u519b\u836f\u5b66\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e34\u5e8a\u836f\u7406\u4e13\u4e1a\u59d4\u5458\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\uff0c\u4e2d\u56fd\u836f\u7406\u5b66\u4f1a\u4e34\u5e8a\u836f\u7406\u4e13\u4e1a\u59d4\u5458\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\u3002<\/p>\n

\u9752\u84bf\u7425\u916f\u7247\u5728\u5065\u5eb7\u4eba\u4f53\u4e2d\u7684\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76<\/strong>\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:<\/p>\n

\u9752\u84bf\u7425\u916f\u7247\u4e3b\u8981\u6210\u5206\u4e3a\u9752\u84bf\u7425\u916f\uff0c\u4e3a\u9752\u84bf\u7c7b\u7684\u6709\u6548\u884d\u751f\u7269\u3002\u9752\u84bf\u7d20\u7c7b\u836f\u7269\u7684\u6297\u759f\u673a\u5236\u4e4b\u4e00\u662f\u4e0e\u6d3b\u6027\u6c27\u6709\u5173\u3002\u6d3b\u6027\u6c27\u7684\u4ea7\u751f\u5bfc\u81f4\u539f\u866b\u819c\u7cfb\u7edf\u7684\u635f\u5bb3\uff0c\u4ece\u800c\u539f\u866b\u4ee3\u8c22\u529f\u80fd\u7d0a\u4e71\u76f4\u81f3\u6b7b\u4ea1[1-2]\u3002\u9752\u84bf\u7425\u916f\u7684\u4ee3\u8c22\u4ea7\u7269\u53cc\u6c22\u9752\u84bf\u7d20\u4e5f\u5177\u6709\u6d3b\u6027\uff0c\u56e0\u6b64\uff0c\u4e5f\u8981\u8bc4\u4ef7\u5206\u6790\u3002\u6842\u6797\u5357\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u751f\u4ea7\u7684\u9752\u84bf\u7425\u916f\u7247 50 mg \u53ca 100 mg \u5df2\u5728\u56fd\u5185\u4e0a\u5e02 [50 mg \u89c4\u683c\u5df2\u83b7\u5f97\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08WHO\uff09\u7684\u4f9b\u5e94\u5546\u8d44\u683c\u8ba4\u8bc1 ] \u6839\u636e WHO \u53ca\u6211\u56fd\u76f8\u5173\u6cd5\u89c4\u7684\u8981\u6c42\uff0c\u73b0\u8fdb\u884c\u6bcf\u7247\u542b\u9752\u84bf\u7425\u916f 100 mg \u4e0e\u6bcf\u7247\u542b\u9752\u84bf\u7425\u916f50 mg \u7684\u9752\u84bf\u7425\u916f\u7247\u5728\u5065\u5eb7\u6210\u5e74\u7537\u6027\u53d7\u8bd5\u8005\u7684\u4eba\u4f53\u751f\u7269\u7b49\u6548\u6027\uff0c\u540c\u65f6\u8bc4\u4ef7\u9752\u84bf\u7425\u916f\u7247\u5728\u5065\u5eb7\u6210\u5e74\u7537\u6027\u53d7\u8bd5\u8005\u4e2d\u7684\u5b89\u5168\u6027\uff0c\u4e3a\u9752\u84bf\u7425\u916f100 mg \u89c4\u683c\u83b7\u5f97 WHO \u7684\u4f9b\u5e94\u5546\u8d44\u683c\u8ba4\u8bc1\u63d0\u4f9b\u4f9d\u636e\u3002<\/p>\n

1\u3000\u6750\u6599
1.1\u3000\u8bd5\u836f
\u3000\u3000\u53d7\u8bd5\u5236\u5242\uff1a\u9752\u84bf\u7425\u916f\u7247\uff08\u6842\u6797\u5357\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff1b\u89c4\u683c\uff1a\u6bcf\u7247\u542b\u9752\u84bf\u7425\u916f 100 mg\uff1b\u6279\u53f7\uff1aAS111106\uff09\uff1b\u53c2\u6bd4\u5236\u5242\uff1a\u9752\u84bf\u7425\u916f\u7247\uff08\u6842\u6797\u5357\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff1b\u89c4\u683c\uff1a\u6bcf\u7247\u542b\u9752\u84bf\u7425\u916f 50 mg\uff1b\u6279\u53f7\uff1aAS111104\uff09\uff1b\u9752\u84bf\u7425\u916f\u5bf9\u7167\u54c1\uff08\u6b27\u6d32\u836f\u54c1\u8d28\u91cf\u7ba1\u7406\u5c40\uff0c\u6279\u6b2114228\uff0c\u7eaf\u5ea6\uff1a99.8%\uff09\uff1b\u53cc\u6c22\u9752\u84bf\u5bf9\u7167\u54c1\uff08\u6b27\u6d32\u836f\u54c1\u8d28\u91cf\u7ba1\u7406\u5c40\uff0c\u6279\u6b21\uff1a13224\uff0c\u7eaf\u5ea6\uff1a100%\uff09\uff1b\u9752\u84bf\u7d20\uff08\u5185\u6807\uff0c\u65e5\u672c Tokyo Chemical Industry Co.\uff0cLtd\uff0c \u6279 \u53f7\uff1a72KJB\uff0cHPLC\uff0c\u7eaf\u5ea6\uff1e 97.0%\uff09\uff1b\u7532\u9187\uff08\u8d5b\u9ed8\u98de\u4e16\u5c14\u79d1\u6280\u6709\u9650\u516c\u53f8\uff0c\u6279\u53f7134191\uff0c\u7eaf\u5ea6\uff1a99.9%\uff09\uff1b\u4e59\u8148\uff08HPLC\u7ea7\uff0cDuksan\uff0cKorea\uff09\uff1b\u7532\u9178\u94f5\uff08AR \u7ea7\u3001Duksan\uff0cKo-rea\uff09\uff1b\u8bd5\u9a8c\u7528\u6c34\u4e3a\u53bb\u79bb\u5b50\u6c34\uff08\u672c\u5b9e\u9a8c\u5ba4\u81ea\u5236\uff09\uff1bOasis HLB\uff081 cc\uff0c30 mg\uff0cWaters\uff0cUSA\uff09\uff1b\u5176\u4ed6\u8bd5\u5242\u5747\u4e3a\u5206\u6790\u7eaf\u3002<\/p>\n

1.2\u3000\u4eea\u5668
\u3000\u3000\u9ad8\u6548\u6db2\u76f8\u8272\u8c31 – \u4e32\u8054\u8d28\u8c31\u8054\u7528\u4eea\uff08\u5305\u62ec Waters \u9ad8\u6548\u6db2\u76f8\u8272\u8c31\u7cfb\u7edf\u548c Q-Trap 5500\uff0cAB Sciex\uff0cUSA\uff09\uff0c\u6570\u636e\u5904\u7406\u8f6f\u4ef6 Analyst 1.5.1\uff08AB Sciex\uff0cUSA\uff09\u3002\u8272\u8c31\u67f1\uff1aSun Shell C18 column\uff082.1 mm\u00d750 mm\uff0c2.6 \u03bcm\uff0cJapan\uff09\uff1bGL-88B\u00a0 \u65cb\u6da1\u6df7\u5408\u4eea\uff08\u6d77\u95e8\u5e02\u5176\u6797\u8d1d\u5c14\u4eea\u5668\u5236\u9020\u6709\u9650\u516c\u53f8\uff09\uff1bXD105R \u5341\u4e07\u5206\u4e4b\u4e00\u7535\u5b50\u5206\u6790\u5929\u5e73\uff08\u4e2d\u56fd\u4e0a\u6d77\u6885\u7279\u52d2 – \u6258\u5229\u591a\uff09\uff1b\u4f4e\u6e29\u79bb\u5fc3\u673a\uff083K30\uff0cSartorius\uff0cGermany\uff09\uff1bMilli-Q Plus\u00a0 \u7eaf\u6c34\u5668\uff08\u7f8e\u56fd\u5bc6
\u7406\u535a\u4e2d\u56fd\u6709\u9650\u516c\u53f8\uff09\u3002<\/p>\n

2\u3000\u65b9\u6cd5
2.1\u3000\u53d7\u8bd5\u8005\u9009\u62e9
\u3000\u3000\u672c\u7814\u7a76\u5165\u9009\u7684 36 \u4f8b\u4e2d\u56fd\u7537\u6027\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d 31\u4f8b\u4e3a\u6c49\u65cf\uff0c4 \u4f8b\u4e3a\u8499\u53e4\u65cf\uff0c1 \u4f8b\u4e3a\u56de\u65cf\uff0c\u5e73\u5747\u5e74\u9f84\u4e3a\uff0823.69\u00b12.72\uff09\uff0820 \uff5e 29\uff09 \u5c81\uff0c \u8eab\u9ad8\uff081.69\u00b10.06\uff09\uff081.58 \uff5e 1.89\uff09m\uff0c\u4f53\u91cd\uff0859.62\u00b17.49\uff09\uff0850.0 \uff5e 80.4\uff09kg\uff0c\u4f53\u91cd\u6307\u6570\u4e3a\uff0820.8\u00b11.6\uff09\uff0818.1 \uff5e 24.0\uff09kg\u00b7m\uff0d 2\u3002\u8bd5\u9a8c\u524d\u75c5\u53f2\u8be2\u95ee\u3001\u4f53\u683c\u68c0\u67e5\u548c\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u672a\u53d1\u73b0\u5f02\u5e38\u3002\u8bd5\u9a8c\u7ecf\u519b\u4e8b\u533b\u5b66\u79d1\u5b66\u9662\u9644\u5c5e\u89e3\u653e\u519b 307 \u533b\u9662\u4f26\u7406\u59d4\u5458\u4f1a\u6279\u51c6\uff0c\u53d7\u8bd5\u8005\u5747\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\u3002\u5168\u90e8\u8bd5\u9a8c\u5728\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u75c5\u623f\u548c\u533b\u62a4\u4eba\u5458\u76d1\u62a4\u4e0b\u8fdb\u884c\u3002<\/p>\n

2.2\u3000\u8bd5\u9a8c\u65b9\u6848\u548c\u8840\u6837\u91c7\u96c6
\u3000\u3000\u672c\u8bd5\u9a8c\u91c7\u7528\u968f\u673a\u3001\u53cc\u5468\u671f\u3001\u81ea\u8eab\u4ea4\u53c9\u7684\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u5355\u6b21\u53e3\u670d\u7ed9\u836f\uff0c36 \u4f8b\u53d7\u8bd5\u8005\u6309\u968f\u673a\u6570\u5b57\u5206\u4e3a T\u3001R \u7ec4\uff0c\u6bcf\u7ec4\u53d7\u8bd5\u8005\u6bcf\u6b21\u8bd5\u9a8c\u65f6\u5206\u522b\u5355\u6b21\u53e3\u670d\u53d7\u8bd5\u5236\u5242\u6216\u53c2\u6bd4\u5236\u5242 200 mg\u3002
\u3000\u3000\u53d7\u8bd5\u8005\u4e8e\u7528\u836f\u524d\u4e00\u65e5\u5165\u4f4f\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u75c5\u623f\uff0c\u7edf\u4e00\u8fdb\u6e05\u6de1\u5e73\u8861\u81b3\u98df\uff0c\u4fdd\u8bc1\u57fa\u672c\u70ed\u91cf\u5728\u6bcf\u65e5 2000 \uff5e 3000 \u5361\u3002\u670d\u836f\u524d\u4e00\u65e5\u665a\u9910\u540e\u7981\u98df\u4e0d\u7981\u6c34\u81f3\u5c11 10 h\uff0c\u6b21\u65e5\u6668\u8d77\u7a7a\u8179\u53e3\u670d\u7ed9\u836f\uff0c\u670d\u836f\u524d\u91c7\u7a7a\u767d\u8840\u6837 5 m L\u3002\u670d\u836f\u540e 2 h \u53ef\u996e\u6c34\uff0c4 h \u540e\u8fdb\u7edf\u4e00\u6e05\u6de1\u5348\u9910\u3002\u7531\u7814\u7a76\u8005\u6216\u533b\u62a4\u4eba\u5458\u6309\u7167\u9884\u5148\u7684\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u6839\u636e\u53d7\u8bd5\u8005\u6240\u5728\u5206\u7ec4\uff0c\u53d1\u653e\u8bd5\u9a8c\u7528\u836f\uff0c\u4ee5 200 m L \u6e29\u5f00\u6c34\u9001\u670d\u3002\u7ed9\u836f\u5242\u91cf\uff1a\u53d7\u8bd5\u5236\u5242\uff08T\uff09\uff1a\u9752\u84bf\u7425\u916f\u7247 100 mg\/ \u7247\uff0c2 \u7247\uff1b\u53c2\u6bd4\u5236\u5242\uff08R\uff09\uff1a\u9752\u84bf\u7425\u916f\u7247 50 mg\/ \u7247\uff0c4 \u7247\u3002\u8840\u6837\u91c7\u96c6\uff1a\u5206\u522b\u4e8e\u7ed9\u836f\u524d\uff080 h\uff09\u3001\u7ed9\u836f\u540e 10\u300120\u300130\u300145min \u548c 1\u30011.5\u30012\u30012.5\u30013\u30013.5\u30014\u30015\u30016\u30018\u300110\u300112\u300116\u300124 h \u5404\u91c7\u96c6\u9759\u8109\u8840 5 m L \u5de6\u53f3\u7f6e\u4e8e\u809d\u7d20\u5904\u7406\u7684\u8bd5\u7ba1\u4e2d\uff0c\u9759\u7f6e\u7ea6 30 min \u540e\uff0c3000 rmin\uff0d 1\u79bb\u5fc3 10 min\uff0c\u5206\u79bb\u8840\u6d46\uff1b\u8840\u6d46\u6837\u672c\u7f6e\uff0d 20\u2103\u51b0\u7bb1\u4fdd\u5b58\u3002<\/p>\n

2.3\u3000\u8272\u8c31 \/ \u8d28\u8c31\u6761\u4ef6
\u3000\u3000 \u8272 \u8c31 \u67f1\uff1aSun Shell C18\u67f1\uff082.1 mm\u00d750 mm\uff0c2.6 \u03bcm\uff09\uff1b \u67f1 \u6e29 40 \u2103\uff1b \u6d41 \u52a8 \u76f8\uff1aA\uff1a10 mmol\u00b7L\uff0d 1\u7532\u9178 \u94f5\uff1bB\uff1a \u4e59 \u8148\uff1b \u68af \u5ea6 \u6d17 \u8131\uff1a40%B\uff080.15 min\uff09\uff0c40% \uff5e 95%B\uff080.15 \uff5e 2.6 min\uff09\uff0c95%B\uff082.6~3.5 min\uff09\uff0c95% \uff5e 40%B\uff083.5 ~3.7min\uff09\uff0c40%B\uff083.7 \uff5e 5 min\uff09\u3002\u6d41\u901f\uff1a0.35 m L\u00b7min\uff0d 1\uff1b\u8fdb\u6837\u91cf\uff1a2 \u03bcL\uff1b\u81ea\u52a8\u8fdb\u6837\u5668\u6e29\u5ea6\uff1a4\u2103\u3002
\u3000\u3000\u79bb\u5b50\u6e90\u4e3a\u7535\u55b7\u96fe\u7535\u79bb\u6e90\uff08ESI\uff09\uff0c\u6b63\u79bb\u5b50\u65b9\u5f0f\u68c0\u6d4b\uff1b\u6e90\u55b7\u5c04\u7535\u538b\u4e3a 5000 V\uff0c\u6e90\u6e29\u5ea6\u4e3a 550\u2103\u3002\u626b\u63cf\u65b9\u5f0f\u4e3a\u591a\u53cd\u5e94\u76d1\u6d4b\uff08MRM\uff09\uff0c\u7528\u4e8e\u5b9a\u91cf\u5206\u6790\u7684\u79bb\u5b50\u5bf9\u5206\u522b\u4e3am\/z 402 \u2192 163\uff08\u9752\u84bf\u7425\u916f\uff09\uff1bm\/z 302 \u2192 163\uff08\u53cc\u6c22\u9752\u84bf\u7d20\uff09\uff1bm\/z 283 \u2192 173\uff08\u9752\u84bf\u7d20\uff09\u3002<\/p>\n

2.4\u3000\u6837\u54c1\u5904\u7406
\u3000\u3000\u56fa\u76f8\u8403\u53d6\u8be6\u7ec6\u6b65\u9aa4\u5982\u4e0b\uff1a\u2460\u6d3b\u5316\uff1a\u56fa\u76f8\u8403\u53d6\u67f1\u9884\u5148\u7ecf 1 m L \u7532\u9187\u548c 1 m L 0.6 mol-L\uff0d 1\u4e59\u9178\u6d3b\u5316\uff1b\u2461\u4e0a\u6837\uff1a\u5411 1 m L \u7684\u8840\u6d46\u4e2d\u52a0\u5165 20 \u03bcL \u6807\u51c6\u5de5\u4f5c\u6eb6\u6db2\uff08\u542b\u6709\u9752\u84bf\u7425\u916f \/ \u53cc\u6c22\u9752\u84bf\u7d20 0.1\/0.1\u30010.25\/0.25\u30010.5\/0.5\u30011.25\/1.25\u30012.5\/2.5\u300112.5\/12.5\u300131.25\/31.25\u300150\/50 \u03bcg\u00b7m L\uff0d 1\u7684\u7532\u9187\u6eb6\u6db2\uff09\u548c 20 \u03bcL \u5185\u6807\u6eb6\u6db2\uff085 \u03bcg\/m L\uff0d 1\uff09\uff0c\u6da1\u65cb \u6df7 \u5300\uff0c \u53d6 200 \u03bcL \u6df7 \u5408 \u6eb6 \u6db2 \u4e0a \u6837\uff1b \u2462 \u6dcb \u6d17\uff1a1 m L 0.6 molL\uff0d 1\u4e59\u9178\u6dcb\u6d17\u67f1\u5b50\uff12\u6b21\u540e\uff0c1 m L \u7532\u9187 -0.6 molL\uff0d 1\u4e59\u9178\uff081\u22364\uff0cv\/v\uff09\u518d\u6dcb\u6d17 1 \u6b21\uff08\u8be5\u6b65\u76ee\u7684\u662f\u4e3a\u4e86\u53bb\u9664\u8840\u91cc\u9762\u6742\u8d28\uff09\uff1b\u2463\u6d17\u8131\uff1a\u7528 1.6 m L \u4e59\u9178\u4e59\u916f – \u4e59\u8148\uff081\u22361\uff0cv\/v\uff09\u6d17\u8131\uff0c50\u2103\u6c2e\u6c14\u6325\u5e72\uff1b\u2464\u590d\u6eb6\uff1a\u6b8b\u7559\u7269\u7528 200 \u03bcL \u6d41\u52a8\u76f8\u590d\u6eb6\uff0c14 000 r\u00b7min\uff0d 1\u79bb\u5fc3 5 min\u3002\u5c06\u4e0a\u6e05\u6db2\u8f6c\u79fb\u81f3\u8fdb\u6837\u5c0f\u74f6\uff0c2 \u03bcL \u8fdb\u6837\u3002
2.5\u3000\u4e13\u5c5e\u6027\u8bd5\u9a8c
\u3000\u3000\u672c\u65b9\u6cd5\u7279\u5f02\u6027\u597d\uff0c\u9752\u84bf\u7425\u916f\u3001\u53cc\u6c22\u9752\u84bf\u7d20\u548c\u5185\u6807\u5178\u578b\u7684 MRM \u8272\u8c31\u56fe\u89c1\u56fe 1\u3002\u7ed3\u679c\u8868\u660e\uff0c\u7a7a\u767d\u8840\u6d46\u4e2d\u7684\u5185\u6e90\u6027\u7269\u8d28\u4e0d\u5e72\u6270\u9752\u84bf\u7425\u916f\u3001\u53cc\u6c22\u9752\u84bf\u7d20\u548c\u5185\u6807\u7684\u6d4b\u5b9a\u3002\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:<\/p>\n

2.6\u3000\u7ebf\u6027\u8303\u56f4
\u3000\u3000\u9752\u84bf\u7425\u916f\u548c\u53cc\u6c22\u9752\u84bf\u7d20\u7684\u6807\u51c6\u66f2\u7ebf\u5206\u522b\u4e3a\uff1ay \uff1d2.71x \uff0b 0.0238\uff0cr \uff1d 0.9956\uff0cy \uff1d 2.49x \uff0b 0.0121\uff0cr\uff1d 0.9975\uff0c\u6743\u91cd\u7cfb\u6570 w \uff1d 1\/x2\uff0c\u4e24\u5f85\u6d4b\u7269\u7ebf\u6027\u8303\u56f4\u5747\u4e3a 2 \uff5e 1000 ng\u00b7m L\uff0d 1\uff0c\u7ebf\u6027\u5173\u7cfb\u826f\u597d\u3002
2.7\u3000\u7cbe\u5bc6\u5ea6\u3001\u51c6\u786e\u5ea6
\u3000\u3000\u5b9a\u91cf\u4e0b\u9650\u3001\u4f4e\u3001\u4e2d\u3001\u9ad8\uff082\u30014\u300150\u3001800 ng-m L\uff0d 1\uff094 \u4e2a\u6d53\u5ea6\u4e2d\uff0c\u9752\u84bf\u7425\u916f\u7684\u65e5\u5185\u7cbe\u5bc6\u5ea6\uff08RSD\uff09\u5206\u522b5.7%\u30013.1%\u30014.7% \u548c 7.2%\uff0c\u53cc\u6c22\u9752\u84bf\u7d20\u5206\u522b\u4e3a 6.1%\u30019.4%\u30016.1% \u548c 7.5%\uff1b\u9752\u84bf\u7425\u916f\u51c6\u786e\u5ea6\u5206\u522b\u4e3a98.4%\u300189.8%\u300192.3% \u548c 88.0%\uff0c\u53cc\u6c22\u9752\u84bf\u7d20\u5206\u522b\u4e3a 99.4%\u300198.8%\u300195.6% \u548c 95.8%\u3002<\/p>\n

2.8\u3000\u7a33\u5b9a\u6027\u8bd5\u9a8c
\u3000\u3000\u7ecf\u8003\u5bdf\uff0c\u9752\u84bf\u7425\u916f\u7684\u4f4e\u3001\u4e2d\u3001\u9ad8\u8d28\u63a7\u5ba4\u6e29\u653e\u7f6e 6 h\u4e0d\u7a33\u5b9a\uff0c\u53cc\u6c22\u9752\u84bf\u7d20\u4f4e\u8d28\u63a7\u5ba4\u6e29\u653e\u7f6e 24 h \u4e0d\u7a33\u5b9a\u3002\u4f46\u662f 4\u2103\u653e\u7f6e 24 h \u5747\u662f\u7a33\u5b9a\u7684\uff08\u89c1\u8868 1 \uff5e 2\uff09\u3002\u56e0\u6b64\u6837\u54c1\u6eb6\u89e3\u540e\u9700\u5b58\u653e\u5728 4\u2103\u6216\u66f4\u4f4e\u7684\u73af\u5883\u4e2d\u8fdb\u884c\u5904\u7406\u3002\u8840\u6d46\u6837\u54c1\u7ecf 2 \u6b21\u51b7\u51bb – \u89e3\u51bb\u5faa\u73af\u7a33\u5b9a\uff0c\u8840\u6d46\u54c1\uff0d 70\u2103\u653e\u7f6e 70 d \u7a33\u5b9a\u3002\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:<\/p>\n

2.9\u3000\u63d0\u53d6\u56de\u6536\u7387\u4e0e\u57fa\u8d28\u6548\u5e94<\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u9752\u84bf\u7425\u916f\u4f4e\u3001\u4e2d\u3001\u9ad8\u6d53\u5ea6\u7684\u63d0\u53d6\u56de\u6536\u7387\u5206\u522b\u4e3a\uff0893.8\u00b11.3\uff09%\u3001\uff08103.8\u00b11.3\uff09% \u548c\uff08105.32\u00b12.4\uff09%\uff1b\u53cc\u6c22\u9752\u84bf\u7d20\u4f4e\u3001\u4e2d\u3001\u9ad8\u6d53\u5ea6\u7684\u63d0\u53d6\u56de\u6536\u7387\u5206\u522b\u4e3a\uff0897.6\u00b11.9\uff09%\u3001\uff0895.3\u00b12.1\uff09% \u548c\uff08107.9\u00b11.9\uff09%\uff1b\u5185\u6807\u7684\u63d0\u53d6\u56de\u6536\u7387\u4e3a\uff0897.4\u00b11.5\uff09%\uff1b\u9752\u84bf\u7425\u916f\u4f4e\u3001\u4e2d\u3001 \u9ad8 \u6d53 \u5ea6 \u7684 \u57fa \u8d28 \u6548 \u5e94 \u5206 \u522b \u4e3a\uff0879.62\u00b16.48\uff09%\u3001\uff0885.23\u00b13.21\uff09% \u548c\uff0899.5\u00b13.35\uff09%\uff1b\u53cc\u6c22\u9752\u84bf\u7d20\u4f4e\u3001\u4e2d\u3001\u9ad8\u6d53\u5ea6\u7684\u57fa\u8d28\u6548\u5e94\u5206\u522b\u4e3a\uff0882.72\u00b14.41\uff09%\u3001\uff0897.2\u00b13.2\uff09% \u548c\uff0894.0\u00b16.1\uff09%\u3002<\/p>\n

\n

3\u3000\u7ed3\u679c
3.1\u3000\u8840\u836f\u6d53\u5ea6 – \u65f6\u95f4\u66f2\u7ebf\u4e0e\u836f\u52a8\u5b66\u53c2\u6570
\u3000\u300036 \u4f8b\u53d7\u8bd5\u8005\u7a7a\u8179\u53e3\u670d\u53d7\u8bd5\u5236\u5242\u548c\u53c2\u6bd4\u5236\u5242 400 mg\u540e\uff0c\u9752\u84bf\u7425\u916f\u548c\u53cc\u6c22\u9752\u84bf\u7d20\u7684\u836f\u52a8\u5b66\u53c2\u6570\u89c1\u5217\u4e8e\u8868 3\uff0c\u836f\u65f6\u66f2\u7ebf\u89c1\u56fe 2 \uff5e 3\u3002
3.2\u3000\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76
\u3000\u3000\u5c06\u53d7\u8bd5\u5236\u5242\u4e0e\u53c2\u6bd4\u5236\u5242\u7684\u9752\u84bf\u7425\u916f\u548c\u53cc\u6c22\u9752\u84bf\u7d20\u7684 AUC0 \uff5e t\u3001tmax\u3001\u548c Cmax\u7b49\u53c2\u6570\u4f5c\u4e3a\u6307\u6807\uff0c\u8fdb\u884c\u4e24\u836f\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u3002\u53d7\u8bd5\u5236\u5242\u4e0e\u53c2\u4e0e\u5236\u5242\u7684\u9752\u84bf\u7425\u916f\u548c\u53cc\u6c22\u9752\u84bf\u7d20\u7684 AUC0 \uff5e t\u548c Cmax\u51e0\u4f55\u5747\u503c\u6bd4\u7684 90% \u53ef\u4fe1\u533a\u95f4\u5747\u5728 80% \uff5e 125%\uff0c\u6ee1\u8db3\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u6807\u51c6\uff08\u89c1\u8868 4\uff09\u3002tmax\u7ecf\u975e\u53c2\u6570\u6cd5\u68c0\u9a8c\u5dee\u5f02\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\uff08P\uff1e 0. 05\uff09\u3002\u8be5\u7ed3\u679c\u8868\u660e 2 \u79cd\u5242\u578b\u5177\u6709\u751f\u7269\u7b49\u6548\u6027\u3002\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:<\/p>\n

4\u3000\u8ba8\u8bba\u4e0e\u7ed3\u8bba
\u3000\u3000\u672c\u6b21\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u672a\u51fa\u73b0\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u8bd5\u9a8c\u7ed3\u675f\u540e\u8840\u751f\u5316\u3001\u8840\u5e38\u89c4\u548c\u5c3f\u5e38\u89c4\u68c0\u67e5\u4e2a\u522b\u6307\u6807\u5f02\u5e38\uff0c\u5747\u4e3a\u8f7b\u5ea6\uff0c\u672a\u91c7\u53d6\u4efb\u4f55\u63aa\u65bd\u5373\u53ef\u81ea\u884c\u6062\u590d\u3002
\u3000\u3000\u5728\u672c\u6b21\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\uff0c\u6240\u6709\u53d7\u8bd5\u8005\u7684\u51dd\u8840\u529f\u80fd\u68c0\u67e5\u4e2d\uff0c\u9664\u6d3b\u5316\u90e8\u5206\u51dd\u8840\u6d3b\u9176\u65f6\u95f4\uff08APTT\uff09\u51fa\u5f02\u5e38\u5916\uff0c\u5176\u4f59\u5404\u9879\uff08\u51dd\u8840\u9176\u539f\u65f6\u95f4 PT\u3001\u6d3b\u52a8\u5ea6\u51dd\u8840\u9176\u539f\u65f6\u95f4\u6bd4\u503c PTR\u3001\u56fd\u9645\u6b63\u5e38\u5316\u6bd4\u503c INR\uff09\u5747\u672a\u51fa\u73b0\u5f02\u5e38\uff0cAPTT
\u5f02\u5e38\u662f\u5426\u4e0e\u8bd5\u9a8c\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\u6709\u5173\u8fd8\u6709\u5f85\u8fdb\u4e00\u6b65\u63a2\u7d22\u3002\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:<\/p>\n

\u3000\u3000\"\u5218\u6cfd\u6e90\u8001\u5e08:\"\u5218\u6cfd\u6e90\u8001\u5e08:<\/p>\n

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