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\u539f\u6587\u94fe\u63a5<\/a><\/strong><\/p>\n

\"\u9057\u4f20\u5b66\u7814\u7a76\u518d\u6b21\u8bc1\u5b9e:<\/p>\n

\"\u9057\u4f20\u5b66\u7814\u7a76\u518d\u6b21\u8bc1\u5b9e:\"\u9057\u4f20\u5b66\u7814\u7a76\u518d\u6b21\u8bc1\u5b9e:<\/figure>\n

\n

\u7ef4\u751f\u7d20D\u53ef\u8c03\u8282\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\uff0c\u65e2\u5f80\u7814\u7a76\u53d1\u73b0\uff0c\u8840\u6d46\u4e2d\u8f83\u4f4e\u768425-\u7f9f\u57fa\u7ef4\u751f\u7d20D\u6d53\u5ea6\u4e0e\u6210\u4eba\u3001\u513f\u7ae5\u548c\u5a74\u513f\u547c\u5438\u9053\u611f\u67d3\u98ce\u9669\u589e\u52a0\u6709\u5173\u3002\u4f46\u5173\u4e8e\u8865\u5145\u7ef4\u751f\u7d20D\u5bf9\u547c\u5438\u9053\u611f\u67d3\u7684\u5f71\u54cd\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7684\u7ed3\u679c\u4e0d\u5c3d\u76f8\u540c\u3002\u7efc\u5408\u4e86\u8fd9\u4e9b\u7814\u7a76\u7684\u4e00\u9879meta\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u8865\u5145\u7ef4\u751f\u7d20D\u5bf9\u547c\u5438\u9053\u611f\u67d3\u5177\u6709\u6709\u76ca\u6548\u679c\u3002\u4e3a\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u8fd9\u4e00\u7ed3\u8bba\uff0c\u672c\u7814\u7a76\u4ece\u53e6\u4e00\u4e2a\u89d2\u5ea6\u51fa\u53d1\u2014\u2014\u9057\u4f20\u5b66\uff0c\u5e76\u7efc\u5408\u4e86\u89c2\u5bdf\u6027\u7814\u7a76\u4ee5\u5206\u6790\u4f4e25-\u7f9f\u57fa\u7ef4\u751f\u7d20D\u4e0e\u7ec6\u83cc\u6027\u80ba\u708e\u98ce\u9669\u7684\u5173\u7cfb\u3002 <\/p>\n

\n

\u7814\u7a76\u65b9\u6cd5<\/strong>
\u7814\u7a76\u4ece\u54e5\u672c\u54c8\u6839\u57ce\u5e02\u5fc3\u810f\u7814\u7a76\u548c\u54e5\u672c\u54c8\u6839\u666e\u901a\u4eba\u7fa4\u7814\u7a76\u4e2d\u968f\u673a\u7eb3\u5165\u4e86116,335\u4f8b20-100\u5c81\u7684\u4e39\u9ea6\u767d\u4eba\u5e76\u5bf9\u5176\u8840\u6d4625-\u7f9f\u57fa\u7ef4\u751f\u7d20D\u51cf\u5c11\u7684\u57fa\u56e0\u53d8\u5f02\u8fdb\u884c\u5206\u578b\uff0c\u4e3a CYP2R1(rs117913124\u3001rs12794714\u548crs10741657)\u3001DHCR7 (rs7944926\u548crs11234027)\u3001GEMIN2 (rs2277458)\u548cHAL (rs3819817)\u3002\u5bf9\u53ef\u91c7\u5f97\u8840\u6d4625-\u7f9f\u57fa\u7ef4\u751f\u7d20D\u4fe1\u606f\u768435 ,833\u4f8b\u4e2a\u4f53\u8fdb\u884c\u4e86\u533b\u9662\u8bca\u65ad\u968f\u8bbf\u4ee5\u83b7\u5f97\u7ec6\u83cc\u6027\u80ba\u708e\u7684\u76f8\u5173\u4fe1\u606f\uff081981-2018\u5e74\uff09\u3002 \u9664\u7ef4\u751f\u7d20D\u548c\u7ec6\u83cc\u6027\u80ba\u708e\u7684\u76f8\u5173\u4fe1\u606f\u5916\uff0c\u7814\u7a76\u8fd8\u5bf9\u60a3\u8005\u8fdb\u884c\u4e86\u57fa\u56e0\u5206\u578b\uff0c\u5e76\u7eb3\u5165\u4e86\u5c3f\u8def\u611f\u67d3\u3001\u76ae\u80a4\u611f\u67d3\u3001\u8d25\u8840\u75c7\u548c\u80c3\u80a0\u708e\u4f5c\u4e3a\u9634\u6027\u5bf9\u7167\uff1b\u6f5c\u5728\u6df7\u6742\u56e0\u7d20\u5305\u62ec\u4f53\u91cd\u6307\u6570(BMI)\u3001\u5438\u70df\u72b6\u6001\u3001\u996e\u9152\u91cf\u3001\u4f30\u8ba1\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387(eGFR)\u3001\u57fa\u7ebf\u65f6\u5408\u5e76\u7684\u6162\u6027\u75c5\uff08\u7cd6\u5c3f\u75c5\u3001\u7f3a\u8840\u6027\u5fc3\u810f\u75c5\u3001\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u548c\u764c\u75c7\uff09\u3002\u7814\u7a76\u5206\u6790\u4e86\u7ef4\u751f\u7d20D\u6c34\u5e73\u3001\u57fa\u56e0\u578b\u4e0e\u7ec6\u83cc\u6027\u80ba\u708e\u53ca\u5c3f\u8def\u611f\u67d3\u7b49\u9634\u6027\u5bf9\u7167\u7684\u5173\u7cfb\uff0c\u5e76\u5bf9\u6df7\u6742\u56e0\u7d20\u8fdb\u884c\u4e86\u6821\u6b63\u3002 <\/p>\n

\n

\u7814\u7a76\u7ed3\u679c<\/strong>
\u5728\u957f\u8fbe38\u5e74\u7684\u968f\u8bbf\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5728\u89c2\u5bdf\u6027\u7814\u7a76\u4e2d\u89c2\u5bdf\u52306,342\uff0835,833\uff0c17.6%\uff09\u4f8b\u7ec6\u83cc\u6027\u80ba\u708e\uff0c\u5728\u9057\u4f20\u5206\u6790\u4e2d\u89c2\u5bdf\u523013,916\uff08116,335\uff0c12.0%\uff09\u4f8b\u7ec6\u83cc\u6027\u80ba\u708e\u3002\u00a0\u5728\u89c2\u5bdf\u6027\u5206\u6790\u4e2d\uff0c\u4e0e25-\u7f9f\u57fa\u7ef4\u751f\u7d20D\u226525 nmol\/L\u7684\u4e2a\u4f53\u76f8\u6bd4\uff0c<25 nmol\/L\u7684\u4e2a\u4f53\u60a3\u7ec6\u83cc\u6027\u80ba\u708e\u7684\u98ce\u9669\u589e\u52a0\uff0c\u7ec6\u83cc\u6027\u80ba\u708e\u7684HR\uff08\u7ecf\u591a\u53d8\u91cf\u6821\u6b63\u540e\uff09\u4e3a1.27 (95%CI\uff1a1.16-1.40)\uff0c\u8fdb\u4e00\u6b65\u7ec6\u5206\u4e5f\u89c2\u5bdf\u5230\u7c7b\u4f3c\u7ed3\u679c\uff08\u8be6\u89c1\u88681\uff09\u3002\u4f46\u672a\u89c2\u5bdf\u523025-\u7f9f\u57fa\u7ef4\u751f\u7d20D\u6d53\u5ea6\u4e0e\u5c3f\u8def\u611f\u67d3\u3001\u76ae\u80a4\u611f\u67d3\u3001\u8d25\u8840\u75c7\u6216\u80c3\u80a0\u708e\u98ce\u9669\u4e4b\u95f4\u6709\u660e\u663e\u5173\u8054\uff0c\u800c\u5728<12.5 nmol\/L\u7684\u4e2a\u4f53\u548c12.5 – 24.9 nmol\/L\u7684\u4e2a\u4f53\u4e2d\u5206\u522b\u53d1\u73b0\u4e0e\u76ae\u80a4\u611f\u67d3\u548c\u8d25\u8840\u75c7\u98ce\u9669\u76f8\u5173\u3002\u00a0\u88681.\u4e0d\u540c25-\u7f9f\u57fa\u7ef4\u751f\u7d20D\u6c34\u5e73\u4e2a\u4f53\u7ec6\u83cc\u6027\u80ba\u708e\u7684\u98ce\u9669\uff08\u7ecf\u591a\u53d8\u91cf\u6821\u6b63\u540e\uff09<\/p>\n

\u7ef4\u751f\u7d20D\u7684ng\u548cnmol\u600e\u4e48\u6362\u7b97<\/strong>
ng\/mL=\u7eb3\u514b\u6bcf\u6beb\u5347
nmol\/L=\u7eb3\u6469\u5c14\u6bcf\u5347
\u6362\u7b97\u516c\u5f0f\u4e3a:
1ng\/mL= 2.5nmol\/L
ng\/mL\u00d72.5=nmol\/L
\u200bnmol\/L\u00f72.5=ng\/mL<\/mark><\/p>\n

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\u7814\u7a76\u8ba8\u8bba<\/strong>
CYP2R1(rs117913124\uff0crs12794714\u548crs10741657)\u7684\u57fa\u56e0\u53d8\u5f02\u4e0e\u7ec6\u83cc\u6027\u80ba\u708e\u7684\u98ce\u9669\u589e\u52a0\u76f8\u5173\uff0c\u800cDHCR7\u3001GEMIN2\u6216HAL\u53d8\u5f02\u5219\u672a\u89c2\u5bdf\u5230\u660e\u663e\u76f8\u5173\u6027\u3002\u4e00\u79cd\u53ef\u80fd\u7684\u89e3\u91ca\u662f\uff0c\u4e0e\u5176\u4ed6\u57fa\u56e0\u76f8\u6bd4CYP2R1\u66f4\u76f4\u63a5\u5730\u53c2\u4e0e1\uff0c25-\u7f9f\u57fa\u7ef4\u751f\u7d20D\u7684\u5f62\u6210\uff0c\u4f46DHCR7\u53c2\u4e0e\u7ef4\u751f\u7d20D\u7684\u4ee3\u8c22\u4f5c\u7528\uff0c\u800cGEMIN2\u548cHAL\u7684\u4f5c\u7528\u5c1a\u4e0d\u6e05\u695a\u3002 \u672c\u7814\u7a76\u6709\u6765\u81ea\u666e\u901a\u4eba\u7fa4\u7684\u4e24\u4e2a\u5927\u89c4\u6a21\u72ec\u7acb\u961f\u5217\u3001\u968f\u673a\u9009\u62e9\u7814\u7a76\u5bf9\u8c61\u3001\u968f\u8bbf\u65f6\u95f4\u957f\u3001\u65e0\u5931\u8bbf\u3001\u7814\u7a76\u4e2d\u6709\u5927\u91cf\u7ec6\u83cc\u6027\u80ba\u708e\u4e2a\u4f53\uff08\u8fd9\u4e9b\u75c5\u4f8b\u7531\u533b\u751f\u8bca\u65ad\uff0c\u5177\u6709\u9ad8\u6548\u3001\u51c6\u786e\u6027\uff09\u7b49\u4f18\u52bf\uff0c\u7814\u7a76\u4e25\u8c28\u3001\u51c6\u786e\u5730\u9a8c\u8bc1\u4e86\u4f4e\u7ef4\u751f\u7d20D\u4e0e\u7ec6\u83cc\u6027\u80ba\u708e\u98ce\u9669\u7684\u5173\u7cfb\uff0c\u4f46\u4e5f\u5b58\u5728\u56e0\u7eb3\u5165\u5355\u4e00\u4e39\u9ea6\u767d\u4eba\u7fa4\u4f53\u800c\u53ef\u80fd\u4f7f\u4eba\u53e3\u5206\u5c42\u7684\u590d\u6742\u6027\u548c\u57fa\u56e0\u5206\u578b\u53d7\u5230\u5f71\u54cd\u7b49\u95ee\u9898\u3002 \u672c\u7814\u7a76\u5728\u89c2\u5bdf\u6027\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0c\u7ed3\u5408\u9057\u4f20\u5b66\u7814\u7a76\u9a8c\u8bc1\u4e86\u4f4e\u7ef4\u751f\u7d20D\u4e0e\u7ec6\u83cc\u6027\u80ba\u708e\u98ce\u9669\u589e\u52a0\u6709\u5173\uff0c\u800c\u65e0\u53ef\u9760\u8bc1\u636e\u8868\u660e\u7ef4\u751f\u7d20D\u4e0e\u5176\u4ed6\u5668\u5b98\u7279\u5f02\u6027\u611f\u67d3\u7684\u98ce\u9669\u76f8\u5173\uff0c\u8fd9\u8868\u660e\u8fd9\u79cd\u76f8\u5173\u6027\u53ef\u80fd\u5bf9\u547c\u5438\u9053\u611f\u67d3\uff08\u5982\u7ec6\u83cc\u6027\u80ba\u708e\uff09\u5177\u6709\u7279\u5f02\u6027\u3002<\/p>\n

\u533b\u8109\u901a\u7f16\u8bd1\u81ea\uff1a\u00c7olak Y , Nordestgaard BG, Afzal S. Thorax 2021;76:468\u2013478.<\/p>\n","protected":false},"excerpt":{"rendered":"

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