{"id":67514,"date":"2026-08-20T07:58:49","date_gmt":"2026-08-20T07:58:49","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=67514"},"modified":"2026-08-20T07:58:49","modified_gmt":"2026-08-20T07:58:49","slug":"%e4%b8%93%e5%ae%b6%e8%ae%ba%e5%9d%9b-%e9%9d%99%e8%84%89%e6%b3%a8%e5%b0%84%e9%ab%98%e6%b5%93%e5%ba%a6%e7%bb%b4%e7%94%9f%e7%b4%a0c%e5%9c%a8%e7%99%8c%e7%97%87%e4%b8%ad%e7%9a%84%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=67514","title":{"rendered":"\u4e13\u5bb6\u8bba\u575b | \u9759\u8109\u6ce8\u5c04\u9ad8\u6d53\u5ea6\u7ef4\u751f\u7d20C\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u53ca\u5e94\u7528\u73b0\u72b6"},"content":{"rendered":"<p class=\"wp-block-paragraph\" id=\"activity-name\"><strong><a href=\"https:\/\/mp.weixin.qq.com\/s\/qHqQ0TUE-sDvaHl1rwkK1g\">\u539f\u6587\u94fe\u63a5<\/a><\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u539f\u521b \u533a\u4fca\u6587 <a href=\"void(0);\">\u80bf\u7624\u9632\u6cbb\u7814\u7a76<\/a> <em>2025\u5e742\u67086\u65e5 <\/em><\/p>\n<p class=\"wp-block-paragraph\">\u6765\u6e90\uff1a\u80bf\u7624\u9632\u6cbb\u7814\u7a76,2024\u5e74,\u7b2c51\u5377\u7b2c11\u671f<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>511495 \u5e7f\u5dde\uff0c\u5e7f\u4e1c\u7948\u798f\u533b\u9662\u56fd\u9645\u5065\u5eb7\u7ba1\u7406\u4e2d\u5fc3<\/p>\n<figure class=\"wp-block-table\">\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td><strong>\u5f15\u7528\u672c\u6587\uff1a<\/strong>\u533a\u4fca\u6587. \u9759\u8109\u6ce8\u5c04\u9ad8\u6d53\u5ea6\u7ef4\u751f\u7d20C\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u53ca\u5e94\u7528\u73b0\u72b6[J]. \u80bf\u7624\u9632\u6cbb\u7814\u7a76, 2024, 51(11): 892-897. DOI: 10.3971\/j.issn.1000-8578.2024.24.0514<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p class=\"wp-block-paragraph\"><strong>\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4e13\u5bb6\u8bba\u575b | \u9759\u8109\u6ce8\u5c04\u9ad8\u6d53\u5ea6\u7ef4\u751f\u7d20C\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u53ca\u5e94\u7528\u73b0\u72b6 - \u7b2c1\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4e13\u5bb6\u8bba\u575b | \u9759\u8109\u6ce8\u5c04\u9ad8\u6d53\u5ea6\u7ef4\u751f\u7d20C\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u53ca\u5e94\u7528\u73b0\u72b6 - \u7b2c1\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" data-perfmatters-preload src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/z0OORN8icFwDe3umVKqMmsyRZdKTAe626GwHiaibjEH846wPM3RBiaznQxReeSsUNia9LSaSVpQmzyvCRdpptW7XcDA\/640?wx_fmt=png&amp;from=appmsg&amp;wxfrom=13&amp;tp=wxpic#imgIndex=1\" \/><\/figure>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u533a\u4fca\u6587<\/strong><strong><\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u5e7f\u4e1c\u7948\u798f\u533b\u9662\u526f\u9662\u957f\u517c\u56fd\u9645\u5065\u5eb7\u7ba1\u7406\u4e2d\u5fc3\u4e3b\u4efb\uff0c\u4e3b\u4efb\u533b\u5e08\u3001\u533b\u5b66\u535a\u58eb\u3001\u7855\u58eb\u751f\u5bfc\u5e08\u3002\u66fe\u5728\u82f1\u56fdBarnsly District General Hospital\u8001\u5e74\u75c5\u79d1\u5de5\u4f5c\u3002\u5e7f\u5dde\u5e02\u533b\u5b66\u9ad8\u5c42\u6b21\u4eba\u624d\uff0c\u5e7f\u5dde\u5e02\u756a\u79ba\u533a\u7279\u6b8a\u6d25\u8d34\u4e13\u5bb6\uff0c\u66a8\u5357\u5927\u5b66\u4f18\u79c0\u533b\u5b66\u6559\u5b66\u79d1\u7814\u5de5\u4f5c\u8005\u3002\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u4f1a\u5458\uff0c\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u80bf\u7624\u70ed\u7597\u4e13\u5bb6\u59d4\u5458\u4f1a\u59d4\u5458\uff0c\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u4e34\u5e8a\u8425\u517b\u4e13\u4e1a\u59d4\u5458\u4f1a\u9752\u5e74\u5e38\u52a1\u59d4\u5458\uff0c\u5e7f\u4e1c\u7701\u533b\u5e08\u534f\u4f1a\u80bf\u7624MDT\u4e13\u4e1a\u59d4\u5458\u4f1a\u5e38\u52a1\u59d4\u5458\u3002\u4e3b\u6301\u5e7f\u4e1c\u7701\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u7701\u3001\u5e02\u7ea7\u57fa\u91d110\u4f59\u9879\u3002\u62c5\u4efbScientific Reports\u7f16\u59d4\uff1b\u9996\u6b21\u5728\u56fd\u5185\u5f00\u5c55\u9759\u8109\u6ce8\u5c04\u9ad8\u6d53\u5ea6\u7ef4\u751f\u7d20C\u8054\u5408\u5c04\u9891\u6df1\u90e8\u70ed\u7597\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u2160\u671f\u548c\u2161\u671f\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u7814\u7a76\u7ed3\u679c\u5728\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u5e74\u4f1a\uff08ASCO\uff09\u3001\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WSCLC\uff09\u3001\u6b27\u6d32\u80bf\u7624\u5b66\u5e74\u4f1a\uff08ESMO\uff09\u3001\u65e5\u672c\u80bf\u7624\u5b66\u5e74\u4f1a\uff08JSMO\uff09\u8fdb\u884c\u58c1\u62a5\u4ea4\u6d41\u53ca\u53e3\u5934\u62a5\u544a\uff0c\u83b7\u5f97\u540c\u884c\u5e7f\u6cdb\u5173\u6ce8\u4e0e\u9ad8\u5ea6\u8bc4\u4ef7\uff1b\u4ee5\u7b2c\u4e00\u4f5c\u8005\/\u901a\u8baf\u4f5c\u8005\u53d1\u8868\u8bba\u6587\u4e8e\u88abSCI\u6536\u5f55\u7684Journal of Free Radical Biology And Medicine\u548cJournal of Advanced Research\u7b49\u77e5\u540d\u671f\u520a\u3002\u53c2\u4e0e\u7f16\u5199\u56fd\u5185\u533b\u5b66\u6307\u5357\u548c\u5171\u8bc64\u90e8\uff0c\u4e3b\u7f16\u548c\u53c2\u7f16\u4e13\u84578\u90e8 \u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u3010\u6458\u8981\u3011<\/strong>\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u9759\u8109\u8f93\u6ce8\u9ad8\u6d53\u5ea6\u7ef4\u751f\u7d20C\uff08HVC\uff09\u5728\u5404\u7c7b\u764c\u75c7\u60a3\u8005\u4e2d\u4f7f\u7528\u662f\u5b89\u5168\u7684\u3002\u4e14\u90e8\u5206\u4e34\u5e8a\u7814\u7a76\u63d0\u793a\u5176\u4e0e\u653e\u3001\u5316\u7597\u8054\u5408\u4f7f\u7528\u80fd\u51cf\u8f7b\u653e\u5316\u7597\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\u3002\u4f53\u5916\u53ca\u52a8\u7269\u5b9e\u9a8c\u8868\u660e\uff0c\u9ad8\u6d53\u5ea6\u7ef4\u751f\u7d20C\uff08VitC\uff09\u5177\u6709\u4fc3\u6c27\u5316\u3001\u9006\u8f6c\u4e0a\u76ae\u95f4\u5145\u8d28\u8f6c\u5316\u3001\u6291\u5236\u7f3a\u6c27\u548c\u81f4\u764c\u6fc0\u9176\u4fe1\u53f7\u8f6c\u5bfc\u4ee5\u53ca\u589e\u5f3a\u514d\u75ab\u529f\u80fd\u7b49\u4f5c\u7528\u3002\u5c3d\u7ba1\u65e2\u5f80\u5df2\u7ecf\u53d1\u8868\u4e86\u5f88\u591a\u2160\/\u2161\u671f\u7684\u4e34\u5e8a\u7814\u7a76\u548c\u75c5\u4f8b\u62a5\u544a\u8bc1\u5b9eHVC\u5177\u6709\u8f85\u52a9\u6297\u80bf\u7624\u7684\u4f5c\u7528\uff0c\u7136\u800c\u76ee\u524d\u4ecd\u7f3a\u4e4f\u5927\u6837\u672c\u3001\u591a\u4e2d\u5fc3\u7684\u968f\u673a\u5bf9\u7167\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u6570\u636e\u3002\u672c\u6587\u65e8\u5728\u6df1\u5165\u63a2\u8ba8\u8fd9\u79cd\u4f4e\u6bd2\u7684\u8f85\u52a9\u6297\u80bf\u7624\u6cbb\u7597\u65b9\u6cd5\u5728\u4e34\u5e8a\u4e2d\u7684\u4f5c\u7528\u53ca\u610f\u4e49\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u3010\u5173\u952e\u8bcd\u3011<\/strong>\u9759\u8109\u6ce8\u5c04\uff1b\u9ad8\u6d53\u5ea6\u7ef4\u751f\u7d20C\uff1b\u80bf\u7624\uff1b\u4f5c\u7528\u673a\u5236\uff1b\u751f\u7269\u6807\u5fd7\u7269&nbsp;&nbsp;<\/p>\n<p class=\"wp-block-paragraph\">\n<h3 class=\"wp-block-heading\"><strong>0&nbsp;&nbsp; \u5f15\u8a00<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">\u764c\u75c7\u662f\u4e00\u79cd\u590d\u6742\u7684\u3001\u591a\u56e0\u7d20\u4f5c\u7528\u7684\u7cfb\u7edf\u6027\u75be\u75c5\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\u90fd\u662f\u91cd\u5927\u7684\u533b\u5b66\u95ee\u9898\u548c\u793e\u4f1a\u95ee\u9898\u3002\u5c3d\u7ba1\u624b\u672f\u3001\u653e\u7597\u3001\u9776\u5411\u6cbb\u7597\u548c\u514d\u75ab\u7597\u6cd5\u7b49\u624b\u6bb5\u5747\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u4f46\u4e0d\u540c\u7684\u6cbb\u7597\u65b9\u6cd5\u5404\u6709\u4f18\u7f3a\u70b9\u3002\u836f\u7269\u6cbb\u7597\u7684\u5e94\u7528\uff0c\u5e38\u56e0\u5176\u8010\u836f\u6027\u548c\u4e0d\u826f\u53cd\u5e94\u53d7\u5230\u9650\u5236\u3002\u8fd1\u5e74\u6765\uff0c\u9759\u8109\u8f93\u6ce8\u9ad8\u6d53\u5ea6\u7ef4\u751f\u7d20C\uff08high-dose intravenous vitamin C, HVC\uff09\u4f5c\u4e3a\u4e00\u79cd\u6f5c\u5728\u7684\u8f85\u52a9\u6297\u80bf\u7624\u6cbb\u7597\u65b9\u6cd5\uff0c\u4ee5\u5176\u6210\u672c\u6548\u76ca\u9ad8\u3001\u5b89\u5168\u6027\u5df2\u77e5\u7b49\u4f18\u52bf\u6b63\u9010\u6e10\u5f15\u8d77\u533b\u5b66\u754c\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0cHVC\u5728\u5404\u7c7b\u764c\u75c7\u60a3\u8005\u4e2d\u4f7f\u7528\u662f\u5b89\u5168\u7684\u3002\u90e8\u5206\u4e34\u5e8a\u7814\u7a76\u5df2\u7ecf\u8bc1\u5b9e\uff0c\u5c06HVC\u4e0e\u653e\u5316\u7597\u8054\u5408\u4f7f\u7528\uff0c\u4e0d\u4ec5\u80fd\u591f\u51cf\u8f7b\u60a3\u8005\u653e\u5316\u7597\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u8fd8\u80fd\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\u3002\u4f53\u5916\u53ca\u52a8\u7269\u5b9e\u9a8c\u8fdb\u4e00\u6b65\u63ed\u793a\u4e86\u7ef4\u751f\u7d20C\uff08VitC\uff09\u7684\u591a\u91cd\u6297\u80bf\u7624\u673a\u5236\uff0c\u5c3d\u7ba1\u5df2\u6709\u8bb8\u591a\u2160\/\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u548c\u75c5\u4f8b\u62a5\u544a\u652f\u6301HVC\u5728\u8f85\u52a9\u6297\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\uff0c\u4f46\u76ee\u524d\u4ecd\u7136\u7f3a\u4e4f\u5927\u6837\u672c\u3001\u591a\u4e2d\u5fc3\u7684\u968f\u673a\u5bf9\u7167\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u3002\u8fd9\u4e00\u73b0\u72b6\u9650\u5236\u4e86HVC\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u7684\u5e7f\u6cdb\u5e94\u7528\u3002\u56e0\u6b64\uff0c\u672c\u6587\u5c06\u7cfb\u7edf\u6027\u5730\u56de\u987e\u548c\u5206\u6790HVC\u8f85\u52a9\u6297\u80bf\u7624\u6cbb\u7597\u4f5c\u7528\u53ca\u5e94\u7528\u73b0\u72b6\uff0c\u91cd\u70b9\u5173\u6ce8HVC\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bc4\u4f30\uff0c\u63a2\u8ba8\u5176\u53ef\u80fd\u7684\u4f5c\u7528\u673a\u5236\uff0c\u5e76\u603b\u7ed3\u76ee\u524d\u7814\u7a76\u4e2d\u5b58\u5728\u7684\u95ee\u9898\u548c\u672a\u6765\u7684\u7814\u7a76\u65b9\u5411\u3002&nbsp;<\/p>\n<p class=\"wp-block-paragraph\">\n<h3 class=\"wp-block-heading\"><strong>1&nbsp;&nbsp; HVC\u7684\u836f\u4ee3\u52a8\u529b\u5b66<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">70\u591a\u5e74\u524d\uff0cMcCormick\u53d1\u73b0\u9ad8\u6d53\u5ea6VitC\u53ef\u80fd\u901a\u8fc7\u589e\u52a0\u80f6\u539f\u86cb\u767d\u7684\u5408\u6210\u4ee5\u9884\u9632\u764c\u75c7[1]\u3002\u968f\u540e\uff0cCameron\u548cPauling\u6307\u51fa\u9ad8\u6d53\u5ea6VitC\u5177\u6709\u589e\u5f3a\u57fa\u8d28\u7ea4\u7ef4\u5316\u3001\u4fc3\u8fdb\u6dcb\u5df4\u7ec6\u80de\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u6d78\u6da6\u4ee5\u53ca\u4fdd\u62a4\u80be\u4e0a\u817a\u2014\u5782\u4f53\u8f74\u514d\u53d7\u764c\u75c7\u76f8\u5173\u5e94\u6fc0\u4ea7\u751f\u7684\u8017\u7aed\u7b49\u4f5c\u7528[2]\u3002\u7814\u7a76\u8868\u660e\uff0c\u9759\u8109\u6ce8\u5c04\u548c\u53e3\u670dVitC\u5728\u4f53\u5185\u8fbe\u5230\u7684\u8840\u836f\u6d53\u5ea6\u663e\u8457\u4e0d\u540c\uff1a\u53e3\u670dVitC\u65f6\uff0c\u7a7a\u8179\u8840\u6d46\u6d53\u5ea6\u7ef4\u6301\u5728&lt;100 \u03bcmol\/L\uff0c\u4f46\u5f53\u53e3\u670dVitC\u5242\u91cf\u8d85\u8fc7200 mg\u65f6\uff0c\u836f\u7269\u5438\u6536\u7387\u53ca\u751f\u7269\u5229\u7528\u5ea6\u964d\u4f4e\uff0c\u80be\u810f\u6392\u6cc4\u589e\u52a0[3]\uff1b\u800c\u9759\u8109\u7ed9\u836f\u80fd\u7ed5\u8fc7\u80a0\u9053\u5438\u6536\u7cfb\u7edf\uff0c\u8fbe\u5230\u53e3\u670d\u65e0\u6cd5\u8fbe\u5230\u7684\u8840\u836f\u6d53\u5ea6\u3002\u6709\u7814\u7a76\u663e\u793a\u5f53VitC\u6700\u5927\u8010\u53d7\u53e3\u670d\u5242\u91cf\u4e3a\u6bcf4 h 3 g\u65f6\uff0c\u8840\u6d46VitC\u5cf0\u503c\u6d53\u5ea6\u4e3a 220 \u03bcmol\/L\uff0c\u800c\u9759\u8109\u6ce8\u5c04\u540c\u7b49\u5242\u91cf\u65f6\uff0c\u8840\u6d46VitC\u5cf0\u503c\u6d53\u5ea6\u53ef\u8fbe\u523015 mmol\/L[4]\u3002\u5728\u5065\u5eb7\u4eba\u7fa4\u4e2d\uff0c\u540c\u6837\u662f\u7ed9\u4e881.25 g VitC\uff0c\u9759\u8109\u7ed9\u836f\u7684\u5e73\u5747\u8840\u836f\u5cf0\u503c\u6d53\u5ea6\u6bd4\u53e3\u670d\u7ed9\u836f\u7684\u5e73\u5747\u5cf0\u503c\u9ad86.6\u500d[5]\u3002\u5f53HVC\u7ed9\u836f\u5242\u91cf\u8fbe\u52301 g\/kg\u65f6\uff0c\u8840\u836f\u6d53\u5ea6\u53ef\u7ef4\u6301\u572810 mmol\/L\u4ee5\u4e0a\u7ea64 h[6]\u3002&nbsp;\u7b14\u8005\u4ece2016\u5e74\u5f00\u59cb\u5bf9HVC\u5728\u80bf\u7624\u60a3\u8005\u4e2d\u5e94\u7528\u7684\u5b89\u5168\u6027\u8fdb\u884c\u7814\u7a76\uff0c\u53d1\u73b0\u7a7a\u8179\u8840VitC\u6d53\u5ea6\u4e0e\u80bf\u7624\u5206\u671f\u76f4\u63a5\u76f8\u5173\uff0c\u5206\u671f\u8d8a\u665a\u7684\u60a3\u8005\uff0c\u4f53\u5185VitC\u6d53\u5ea6\u8d8a\u4f4e\uff0c\u5c11\u6570\u665a\u671f\u80bf\u7624\u60a3\u8005\u4f53\u5185\u68c0\u6d4b\u4e0d\u5230VitC\uff0c\u63d0\u793a\u8fd9\u7c7b\u60a3\u8005\u4f53\u5185VitC\u6781\u5ea6\u7f3a\u4e4f\u3002\u6211\u4eec\u8fdb\u884c\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u63d0\u793a\uff0c\u5f53HVC\u57281.5 g\/kg\u65f6\uff0c\u6ce8\u5c042 h\u540e\uff0c\u8840\u6db2\u6700\u9ad8\u6d53\u5ea6\u53ef\u8fbe25 mmol\/L\uff0c8 h\u540e\uff0c\u8840\u836f\u6d53\u5ea6\u964d\u81f32 mmol\/L\u4ee5\u4e0b\u3002\u8f93\u6ce8\u671f\u95f4\uff0c\u4ec5\u5c11\u6570\u60a3\u8005\u51fa\u73b0\u53e3\u6e34\u75c7\u72b6\uff0c\u5076\u6709\u60a3\u8005\u611f\u89c9\u75b2\u5026\uff0c\u4ec5\u67091\u4f8b\u60a3\u8005\u51fa\u73b0\u4e25\u91cd\u8179\u6cfb\u3002\u603b\u4f53\u6765\u770b\uff0c\u9ad8\u6d53\u5ea6HVC\u5728\u80bf\u7624\u60a3\u8005\u4e2d\u7684\u4f7f\u7528\u5f88\u5b89\u5168[7]\u3002&nbsp;\u6b64\u5916\uff0c\u90e8\u5206\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e\uff0c\u5728\u4f7f\u7528HVC\u540e\uff0cVitC\u5728\u5b9e\u4f53\u7624\u4e2d\u7684\u84c4\u79ef\u6d53\u5ea6\u9ad8\u4e8e\u5468\u56f4\u6b63\u5e38\u7ec4\u7ec7\uff0c\u63d0\u793aVitC\u9009\u62e9\u6027\u4f5c\u7528\u4e8e\u80bf\u7624\u7ec4\u7ec7[8]\u3002&nbsp;<\/p>\n<p class=\"wp-block-paragraph\">\n<h3 class=\"wp-block-heading\"><strong>2&nbsp;&nbsp; VitC\u6297\u80bf\u7624\u7684\u4f5c\u7528\u673a\u5236<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">\u76ee\u524d\u5173\u4e8eVitC\u6297\u80bf\u7624\u7684\u4f5c\u7528\u673a\u5236\u5305\u62ec\uff1a\u8bf1\u5bfc\u4ea7\u751f\u8fc7\u6c27\u5316\u6c22\uff08H2O2\uff09\u53ca\u5176\u5bfc\u81f4\u7684\u8fc7\u6c27\u5316\u5e94\u6fc0[9]\u3001\u4ecb\u5bfc\u8868\u89c2\u57fa\u56e0\u7ec4\u8c03\u8282[10]\u3001\u8c03\u63a7\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff08hypoxia-inducible factor, HIF\uff09\u6d3b\u6027[11]\u3001\u8c03\u8282\u4e0a\u76ae\u5230\u95f4\u5145\u8d28\u8f6c\u5316\u548c\u6fc0\u9176\u6d3b\u6027[12]\u3001\u8c03\u8282\u514d\u75ab\u529f\u80fd\u7b49[13]\u3002\u540c\u65f6\uff0cVitC\u8fd8\u5177\u6709\u6291\u5236\u539f\u764c\u57fa\u56e0\u6fc0\u6d3b\u3001\u4e0a\u8c03P53\u7b49\u6291\u764c\u57fa\u56e0\u7684\u8868\u8fbe\u3001\u4fee\u590d\u51cb\u4ea1\u57fa\u56e0\u529f\u80fd\u7d0a\u4e71\u3001\u6539\u5584DNA\u4fee\u590d\u57fa\u56e0\u529f\u80fd\u969c\u788d\u7b49\u6297\u80bf\u7624\u7684\u4f5c\u7528[10]\u3002&nbsp;<\/p>\n<h4 class=\"wp-block-heading\">2.1&nbsp;&nbsp; VitC\u7684\u4fc3\u6c27\u5316\u4f5c\u7528<\/h4>\n<p class=\"wp-block-paragraph\">\u65e2\u5f80\u7814\u7a76\u8868\u660e\uff0cVitC\u7684\u6c27\u5316\u8fd8\u539f\u4f5c\u7528\u5448\u5242\u91cf\u4f9d\u8d56\u6027, \u5f53\u5176\u572830~80 \u03bcmol\/L\u7684\u6b63\u5e38\u8840\u6d46\u6d53\u5ea6\u8303\u56f4\u5185\uff0c\u5176\u4e3b\u8981\u4f5c\u4e3a\u6297\u6c27\u5316\u5242\u53d1\u6325\u4f5c\u7528\uff1b\u800c\u5f53\u5176\u8840\u836f\u6d53\u5ea6\u5347\u9ad8\u81f30.5~20 mmol\/L\u65f6\uff0cVitC\u4f1a\u589e\u52a0\u764c\u7ec6\u80de\u5185\u6d3b\u6027\u6c27\u7c07\uff08ROS\uff09\u7684\u6c34\u5e73\uff0c\u4ee4\u764c\u7ec6\u80de\u7684DNA\u3001\u86cb\u767d\u8d28\u548c\u8102\u8d28\u53d7\u635f[14]\u3002\u8be5\u4f5c\u7528\u673a\u5236\u53ef\u80fd\u662f\uff1a\uff081\uff09\u80bf\u7624\u7ec6\u80de\u4e2d\u6d3b\u6027\u94c1\u79bb\u5b50\uff08Fe2+\uff09\u6c34\u5e73\u589e\u52a0\uff0cFe2+\u4e0e\u8fc7\u6c27\u5316\u6c22\u53cd\u5e94\u5f62\u6210OH\u00b7\uff0c\u901a\u8fc7\u82ac\u987f\u53cd\u5e94\u6301\u7eed\u4ea7\u751fROS\u5e76\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1[15]\uff1b\uff082\uff09\u80bf\u7624\u7ec6\u80de\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767d\uff08GLUTs\uff09\u8fc7\u8868\u8fbe\uff0c\u4ecb\u5bfc\u6c27\u5316\u7ef4\u751f\u7d20C\uff08\u8131\u6c22\u6297\u574f\u8840\u9178\uff0cDHA\uff09\u7684\u6444\u53d6\uff0c\u6d88\u8017\u7ec6\u80de\u5185\u7684\u8fd8\u539f\u7269\u8d28\uff0c\u5982\u8c37\u80f1\u7518\u80bd\u7b49\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u589e\u52a0\u764c\u7ec6\u80de\u4e2dROS\u7684\u6c34\u5e73[16]\uff1b\uff083\uff09\u764c\u7ec6\u80de\u901a\u5e38\u7f3a\u4e4f\u8fc7\u6c27\u5316\u6c22\u9176\uff0c\u4f7f\u5176\u6bd4\u6b63\u5e38\u7ec6\u80de\u66f4\u5bb9\u6613\u53d7\u5230\u6c27\u5316\u5e94\u6fc0\u7684\u653b\u51fb[17]\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0cVitC\u4fc3\u6c27\u5316\u662f\u7814\u7a76\u6700\u5e7f\u6cdb\u7684\u4f5c\u7528\u673a\u5236\u3002&nbsp;<\/p>\n<h4 class=\"wp-block-heading\">2.2&nbsp;&nbsp; VitC\u5bf9\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\u7684\u8c03\u63a7<\/h4>\n<p class=\"wp-block-paragraph\">\u80bf\u7624\u5fae\u73af\u5883\u5448\u73b0\u51fa\u6574\u4f53\u7f3a\u6c27\u7684\u7279\u70b9\uff0c\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff08HIF\uff09\u8c03\u8282\u7ec6\u80de\u5bf9\u7f3a\u6c27\u7684\u53cd\u5e94\uff0c\u662f\u4ecb\u5bfc\u7ec6\u80de\u5bf9\u7f3a\u6c27\u5fae\u73af\u5883\u8fdb\u884c\u9002\u5e94\u6027\u53cd\u5e94\u7684\u5173\u952e\u6027\u8f6c\u5f55\u8c03\u63a7\u56e0\u5b50\uff0c\u5176\u4e2d\u03b1\u4e9a\u57fa\u4e25\u683c\u53d7\u5230\u6c27\u6c14\u6d53\u5ea6\u8c03\u63a7\uff0c\u662fHIF\u7684\u8c03\u8282\u4e9a\u57fa\u3002HIF 1\u03b1\u548cHIF 2\u03b1\u662f\u6700\u91cd\u8981\u7684\u4e24\u4e2a\u8f6c\u5f55\u56e0\u5b50\uff0c\u5df2\u53d1\u73b0\u4e0e\u591a\u79cd\u80bf\u7624\u9884\u540e\u4e0d\u826f\u6709\u5173\uff0c\u901a\u8fc7\u6291\u5236\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\u53c2\u4e0e\u80bf\u7624\u8010\u836f[18]\u3002\u7814\u7a76\u8868\u660e\uff0cVitC\u901a\u8fc7\u8c03\u8282HIF\u7f9f\u5316\u9176\u7684\u529f\u80fd\uff0c\u4ee4HIF-1\u5931\u6d3b\uff0c\u6700\u7ec8\u9776\u5411\u86cb\u767d\u9176\u4f53\u964d\u89e3\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u751f\u957f[19]\u3002VitC\u4e0b\u8c03HIF-1\u03b1\u6d3b\u6027\uff0c\u964d\u4f4e\u9ed1\u8272\u7d20\u7624\u7684\u6076\u6027\u7a0b\u5ea6[20]\u3002Kawada\u7b49[21]\u7814\u7a76\u8868\u660e\uff0c\u9ad8\u5242\u91cfVitC\u53ef\u4e0b\u8c03\u767d\u8840\u75c5\u7ec6\u80deHIF-1\u7684\u6c34\u5e73\u3002Kuiper\u7b49\u5bf9\u7ed3\u80a0\u764c\u4eba\u7fa4\u7684\u7814\u7a76\u8bc1\u5b9e\u4e86\u80bf\u7624\u5185VitC\u7684\u6d53\u5ea6\u4e0eHIF-1\u7684\u6d3b\u6027\u5448\u8d1f\u76f8\u5173\u6027\uff0c\u80bf\u7624\u7ec4\u7ec7\u5185VitC\u6c34\u5e73\u589e\u9ad8\uff0cHIF-1\u901a\u8def\u88ab\u6291\u5236\uff0c\u60a3\u8005\u65e0\u75be\u75c5\u751f\u5b58\u671f\uff08PFS\uff09\u663e\u8457\u5ef6\u957f[22]\u3002\u76f8\u8f83\u6b63\u5e38\u7ec6\u80de\uff0c\u7f3a\u6c27\u662f\u764c\u7ec6\u80de\u7684\u5e38\u89c1\u73b0\u8c61\uff0c\u8fd9\u589e\u52a0\u4e86\u764c\u7ec6\u80de\u5bf9VitC\u7684\u6613\u611f\u6027\u3002&nbsp;<\/p>\n<h4 class=\"wp-block-heading\">2.3&nbsp;&nbsp; VitC\u5bf9\u8868\u89c2\u57fa\u56e0\u8c03\u63a7\u7684\u4f5c\u7528<\/h4>\n<p class=\"wp-block-paragraph\">\u8868\u89c2\u9057\u4f20\u5b66\u6539\u53d8\u662f\u6307\u57fa\u4e8e\u975e\u57fa\u56e0\u5e8f\u5217\u6539\u53d8\u6240\u81f4\u57fa\u56e0\u8868\u8fbe\u6c34\u5e73\u53d8\u5316\uff0c\u5982DNA\u7532\u57fa\u5316\u548c\u7ec4\u86cb\u767d\u4fee\u9970\u7b49\u3002\u80bf\u7624\u4e2dDNA\u9ad8\u7532\u57fa\u5316\u6a21\u5f0f\u591a\u6765\u81eaDNA\u7532\u57fa\u8f6c\u79fb\u529f\u80fd\u83b7\u5f97\u548c10-11\u6613\u4f4d\u86cb\u767d\uff08TET\uff09\u7684\u529f\u80fd\u4e27\u5931\u3002TET\u80fd\u6539\u53d8\u7532\u57fa\u56e2\u7684\u5206\u5b50\u7ed3\u6784\uff0c\u4fc3\u4f7f\u57fa\u56e2\u4ece\u80de\u5627\u5576\u4e0a\u8131\u79bb\uff0c\u4ece\u800c\u53d1\u6325\u5176DNA\u53bb\u7532\u57fa\u5316\u4f5c\u7528[23]\u3002VitC\u4f5c\u4e3a\u8f85\u52a9\u56e0\u5b50\uff0c\u901a\u8fc7\u5411Fe3+\u63d0\u4f9b\u7535\u5b50\u4ee5\u4ea7\u751fFe2+\uff0c\u589e\u5f3aTET\u86cb\u767d\u7684\u6d3b\u6027\uff0c\u4fc3\u8fdbDNA\u53bb\u7532\u57fa\u5316\uff0c\u4fc3\u4f7f\u6291\u764c\u57fa\u56e0\u7684\u91cd\u65b0\u8868\u8fbe\u548c\u5e72\u7ec6\u80de\u5206\u5316[24]\u3002\u7814\u7a76\u8868\u660e\uff0cTET\u7684\u5931\u6d3b\u7a81\u53d8\u548c\u767d\u8840\u75c5\u7684\u53d1\u751f\u6709\u5173\uff0c\u5f53TET\u7a81\u53d8\u548c\u5176\u4ed6\u7a81\u53d8\u540c\u65f6\u51fa\u73b0\u65f6\uff0c\u5c31\u4f1a\u589e\u52a0\u9020\u8840\u5e72\u7ec6\u80de\u7684\u6d3b\u6027\u548c\u81ea\u6211\u66f4\u65b0\uff0c\u8bf1\u53d1\u767d\u8840\u75c5\u3002VitC\u53ef\u4ee5\u901a\u8fc7TET\u6291\u5236\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u7ef4\u6301\u9020\u8840\u5e72\u7ec6\u80de\u5185\u7a33\u6001\u7b49[24]\u3002\u7ec4\u86cb\u767d\u4fee\u9970\u4e5f\u662f\u8868\u89c2\u9057\u4f20\u5b66\u91cd\u8981\u7684\u8c03\u63a7\u673a\u5236\u4e4b\u4e00\uff0c\u53c2\u4e0e\u8c03\u63a7\u57fa\u56e0\u8868\u8fbe\u7b49\u591a\u79cd\u751f\u7269\u5b66\u8fc7\u7a0b\u3002\u7ec4\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176\u53ef\u79fb\u9664\u7ec4\u86cb\u767d\u4e2d\u7cbe\u6c28\u9178\u548c\u8d56\u6c28\u9178\u4e0a\u7684\u7532\u57fa\uff0c\u4f9d\u8d56\u4e8eJumonji C\u7ed3\u6784\u57df\u7684\u94c1\u79bb\u5b50-\u03b1-\u916e\u620a\u4e8c\u9178\u4f9d\u8d56\u7684\u53cc\u6c27\u5408\u9176\u3002VitC\u6c27\u5316\u8fd8\u539f\u6d3b\u6027\u94c1\uff0c\u53ef\u589e\u5f3aJumonji\u5bb6\u65cf\u86cb\u767d\u7684\u53bb\u7532\u57fa\u5316\u4f5c\u7528[25]\u3002\u6700\u8fd1\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u7ed9\u809d\u764c\u52a8\u7269\u6a21\u578b\u6ce8\u5c04HVC\uff0c\u6fc0\u6d3b\u809d\u764c\u7ec4\u7ec7\u7684TET2\u548c\u589e\u5f3a\u5176\u8868\u8fbe\uff0c\u89e6\u53d1\u80bf\u7624cGAS-cGAMP-\u5185\u76aeSTING\u901a\u8def\u6fc0\u6d3b\u5e76\u8bf1\u5bfc\u80bf\u7624\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u663e\u8457\u63d0\u5347\u6297PD-L1\u6297\u4f53\u5355\u7528\u6216\u8054\u5408IL-2\u6cbb\u7597\u809d\u764c\u7684\u6548\u679c[26]\u3002\u56e0\u6b64\uff0cVitC\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u6fc0\u6d3bDNA\u53bb\u7532\u57fa\u5316[27]\uff0c\u4ee4\u6291\u764c\u57fa\u56e0\u91cd\u65b0\u8868\u8fbe\uff0c\u4ee5\u53ca\u589e\u5f3a\u764c\u7ec6\u80de\u5bf9\u6cbb\u7597\u836f\u7269\u7684\u654f\u611f\u6027\u3002&nbsp;<\/p>\n<h4 class=\"wp-block-heading\">2.4&nbsp;&nbsp; VitC\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528<\/h4>\n<p class=\"wp-block-paragraph\">VitC\u5728\u5927\u591a\u6570\u514d\u75ab\u7ec6\u80de\u4e2d\u7ef4\u6301\u9ad8\u6c34\u5e73\u72b6\u6001\uff0c\u5b83\u53ef\u4ee5\u4ece\u591a\u65b9\u9762\u5f71\u54cd\u53ca\u8c03\u8282\u5148\u5929\u514d\u75ab\u529f\u80fd\u548c\u83b7\u5f97\u6027\u514d\u75ab\u529f\u80fd\uff0c\u53c2\u4e0e\u9ad3\u7cfb\u548cT\u7ec6\u80de\u7684\u5206\u5316\u548c\u6781\u5316\u3001T\u7ec6\u80de\u6210\u719f\u548c\u6fc0\u6d3b\u3001B\u7ec6\u80de\u53d1\u80b2\u548c\u8d8b\u5316\u3001\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u548c\u589e\u5f3a\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u4ecb\u5bfc\u7684\u80bf\u7624\u6740\u4f24\u7b49\u8fc7\u7a0b\uff0c\u5728\u7ef4\u6301\u6297\u708e\u53ca\u6297\u80bf\u7624\u65b9\u9762\u8d77\u5173\u952e\u4f5c\u7528[28]\u3002\u7814\u7a76\u8868\u660eVitC\u901a\u8fc7\u6fc0\u6d3bTET\u6d3b\u6027\uff0c\u4fc3\u8fdb\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u529f\u80fd\uff0c\u4ece\u800c\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab[27]\u3002\u6b64\u5916\uff0c\u6709\u7814\u7a76\u5efa\u7acb\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u9ed1\u8272\u7d20\u7624\u548c\u80f0\u817a\u764c\u5c0f\u9f20\u6a21\u578b\uff0c\u53d1\u73b0\u53ea\u6709\u5728\u529f\u80fd\u5b8c\u6574\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u800c\u4e0d\u662f\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u7684\u52a8\u7269\u6a21\u578b\u4e2d\u624d\u80fd\u5145\u5206\u53d1\u6325VitC\u7684\u6297\u80bf\u7624\u4f5c\u7528[29]\u3002\u800cVitC\u53ef\u589e\u52a0CD8+T\u7ec6\u80de\u76845-\u7f9f\u7532\u57fa\u80de\u5627\u5576\u6c34\u5e73\uff0c\u663e\u8457\u589e\u5f3a\u5176\u5bf9\u6dcb\u5df4\u7624\u7ec6\u80de\u7684\u6bd2\u6027[29]\u3002\u5927\u5242\u91cfVitC\u8fd8\u901a\u8fc7\u514d\u75ab\u7ec6\u80de\u8c03\u8282\u80bf\u7624\u5fae\u73af\u5883\u7684\u6d78\u6da6\uff0c\u663e\u8457\u589e\u52a0\u7624\u5185CD8+T\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7684\u6d78\u6da6\uff0c\u589e\u5f3a\u80bf\u7624\u514d\u75ab\u8bc6\u522b\u80fd\u529b\uff0c\u5e76\u80fd\u534f\u540c\u6297PD-1\u548c\u6297CTL-4\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53d1\u6325\u6297\u80bf\u7624\u7684\u4f5c\u7528[30]\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u63d0\u793aHVC\u53ef\u4ee5\u5c06\u201c\u51b7\u201d\u80bf\u7624\u8f6c\u53d8\u4e3a\u201c\u70ed\u201d\u80bf\u7624\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3a\u514d\u75ab\u6cbb\u7597\u7684\u7597\u6548\u3002&nbsp;<\/p>\n<p class=\"wp-block-paragraph\">\n<h3 class=\"wp-block-heading\"><strong>3&nbsp;&nbsp; HVC\u4e0e\u5316\u7597\u8054\u5408\u4f7f\u7528<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u524d\u6a21\u578b\u7684\u7814\u7a76\u8868\u660e\uff0cHVC\u53ef\u589e\u5f3a\u591a\u79cd\u5316\u7597\u836f\u7269\u5982\u987a\u94c2\u3001\u5965\u6c99\u5229\u94c2\u7b49\u7684\u7597\u6548\u5e76\u51cf\u8f7b\u5176\u4e0d\u826f\u53cd\u5e94[31]\uff0c\u5728\u4f7f\u7528HVC\u8054\u5408\u6297\u80bf\u7624\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u8f83\u591a\u91c7\u7528HVC\u7684\u5242\u91cf\u4e3a\uff081~1.5\uff09g\/\uff08kg\u00b7d\uff09\uff0c\u6bcf\u54681~3\u6b21\uff0c\u8fde\u7eed\u4f7f\u75282~3\u4e2a\u6708\uff0c\u4e0e\u653e\u7597\u3001\u5316\u7597\u3001\u9776\u5411\u6cbb\u7597\u8054\u5408\u4f7f\u7528[32-33]\u3002\u5176\u4e2d\uff0cHVC\u5e94\u7528\u5728\u80f0\u817a\u764c\u3001\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u5375\u5de2\u764c\u53ca\u8840\u6db2\u80bf\u7624\u6cbb\u7597\u4e2d\uff0c\u80fd\u663e\u8457\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u53ca\u5ef6\u957f\u751f\u5b58\u671f[33-34]\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u6a21\u578b\u4e2d\uff0cHVC\u4e0e\u5316\u7597\u836f\u7269\u5409\u897f\u4ed6\u6ee8\u8054\u5408\u4f7f\u7528\uff0c\u80fd\u663e\u8457\u7f29\u5c0f\u80bf\u7624\u4f53\u79ef[34]\u3002&nbsp;\u6b64\u5916\uff0cHVC\u4e0eFOLFIRINOX\uff08\u4e9a\u53f6\u9178\u30015-\u6c1f\u5c3f\u5627\u5576\u3001\u4f0a\u7acb\u66ff\u5eb7\u548c\u5965\u6c99\u5229\u94c2\u7684\u7ec4\u5408\uff09\u8054\u5408\u4f7f\u7528\uff0c\u5728\u4f53\u5916\u548c\u52a8\u7269\u5b9e\u9a8c\u4e2d\u5747\u8868\u73b0\u51fa\u663e\u8457\u7684\u534f\u540c\u6297\u80bf\u7624\u6548\u679c\u3002\u4f53\u5916\u5b9e\u9a8c\u663e\u793a\uff0c\u9ad8\u6d53\u5ea6VitC\u4e0eFOLFIRINOX\u8054\u5408\u4f7f\u7528\u663e\u8457\u51cf\u5c11\u4e86\u4ebaPDAC\u7ec6\u80de\u7cfb\u7684\u514b\u9686\u80fd\u529b\uff0c\u5e76\u589e\u52a0\u4e86DNA\u635f\u4f24\u6807\u5fd7\u7269\u03b3H2AX\u7684\u8868\u8fbe\u3002\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0cHVC\u4e0eFOLFIRINOX\u8054\u5408\u4f7f\u7528\u663e\u8457\u964d\u4f4e\u4e86\u80bf\u7624\u751f\u957f\u901f\u7387\uff0c\u5e76\u5ef6\u957f\u4e86\u5c0f\u9f20\u7684\u603b\u751f\u5b58\u671f\uff08Overall survival, OS\uff09[35]\u3002&nbsp;\u4e00\u9879\u5c0f\u6837\u672c\u7684\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0c\u665a\u671f\u80f0\u817a\u764c\u60a3\u8005\u5728\u63a5\u53d7\u5409\u897f\u4ed6\u6ee8\u548c\u5384\u6d1b\u66ff\u5c3c\u8054\u5408HVC\u6cbb\u7597\u4ec58\u5468\u540e\uff0c\u80bf\u7624\u663e\u8457\u7f29\u5c0f\uff0c\u4e14\u4e0d\u826f\u53cd\u5e94\u51cf\u8f7b[36]\u3002Welsh\u7b49\u7ed9\u80f0\u817a\u764c\u60a3\u8005\u4f7f\u7528HVC\u8054\u5408\u5409\u897f\u4ed6\u6ee8\uff0c\u4e5f\u83b7\u5f97\u8f83\u597d\u7684\u7597\u6548[37]\u3002Ma\u7b49[38]\u5bf9\u2162~\u2163\u671f\u5375\u5de2\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0c\u5728\u6807\u51c6\u5316\u7597\uff08\u5361\u94c2\u548c\u7d2b\u6749\u9187\uff09\u7684\u57fa\u7840\u4e0a\u52a0\u7528HVC\uff0c\u4e2d\u4f4d\u65e0\u75be\u75c5\u8fdb\u5c55\u751f\u5b58\u671f\uff08Progression-free survival, PFS\uff09\u6bd4\u5355\u72ec\u5316\u7597\u7ec4\u5ef6\u957f8.75\u4e2a\u6708\u3002\u6211\u56fd\u5b66\u8005\u8fdb\u884c\u7684\u4e00\u9879\u8f6c\u79fb\u6027\u80c3\u548c\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u2160\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u5c06HVC[1.5 g\/(kg\u00b7d)]\u4e0emFOLFOX6\u6216FOLFIRI\u8054\u5408\u4f7f\u7528\uff0c\u5177\u6709\u8f83\u597d\u7684\u5b89\u5168\u6027\uff0c\u51cf\u5c11\u5316\u7597\u836f\u7269\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u663e\u8457\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf[39]\u3002\u8be5\u56e2\u961f\u968f\u540e\u8fdb\u884c\u7684\u5927\u6837\u672c\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u5bf9\u6bd4\u4e86\u5355\u7eaf\u4f7f\u7528FOLFOX\u00b1\u8d1d\u4f10\u73e0\u5355\u6297\u7ec4\u4e0e\u4e0a\u8ff0\u836f\u7269\u8054\u5408HVC\u6cbb\u7597\u7ec4\uff0c\u7ed3\u679c\u663e\u793a\u4e24\u7ec4\u7684PFS\uff088.6 vs. 8.3\u6708\uff0cHR=0.86\uff0cP=0.10\uff09\u3001\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0844.3% vs. 42.1%\uff0cP=0.90\uff09\u548cOS\uff0820.7 vs. 19.7\u6708\uff0cP=0.70\uff09\u5dee\u5f02\u5747\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u7136\u800c\uff0c\u5728\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c\u643a\u5e26RAS\u7a81\u53d8\u7684\u60a3\u8005\u52a0\u7528HVC\u540ePFS\u663e\u8457\u5ef6\u957f\uff089.2 vs. 7.8\u6708\uff0cHR=0.67\uff0cP=0.01\uff09\u3002\u8be5\u7814\u7a76\u63d0\u793aRAS\u7a81\u53d8\u7684\u60a3\u8005\u53ef\u80fd\u4eceHVC\u4e2d\u83b7\u76ca[40]\u3002&nbsp;\u7efc\u4e0a\u6240\u8ff0\uff0cHVC\u4e0e\u591a\u79cd\u5316\u7597\u836f\u7269\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u8868\u73b0\u51fa\u663e\u8457\u7684\u534f\u540c\u6297\u80bf\u7624\u4f5c\u7528\u3002\u8fd9\u79cd\u534f\u540c\u4f5c\u7528\u53ef\u80fd\u901a\u8fc7\u591a\u79cd\u673a\u5236\u5b9e\u73b0\uff0c\u5305\u62ec\u589e\u5f3a\u5316\u7597\u836f\u7269\u7684\u7ec6\u80de\u6bd2\u6027\u3001\u589e\u52a0DNA\u635f\u4f24\u3001\u4e0b\u8c03\u4ee3\u8c22\u9014\u5f84\u7b49\u3002\u7136\u800c\uff0c\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u7814\u7a76\u4ecd\u7136\u9700\u8981\u786e\u5b9a\u5176\u5728\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u548c\u57fa\u56e0\u80cc\u666f\u4e0b\u7684\u5177\u4f53\u7597\u6548\u548c\u5b89\u5168\u6027\u3002&nbsp;<\/p>\n<h3 class=\"wp-block-heading\"><strong>4&nbsp;&nbsp; \u63a2\u7d22\u5bf9HVC\u6cbb\u7597\u654f\u611f\u7684\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">\u7b14\u8005\u65e9\u671f\u8fdb\u884c\u7684\u4e00\u9879\u56de\u987e\u6027\u7814\u7a76\u663e\u793a\uff0cHVC\u4e0e\u5409\u897f\u4ed6\u6ee8\u548c\u5361\u94c2\u8054\u5408\u5e94\u7528\uff0c\u76f8\u6bd4\u5355\u7eaf\u5316\u7597\u7ec4\uff0c\u53ef\u663e\u8457\u5ef6\u957f\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684PFS\u548cOS\uff0c\u5e76\u51cf\u8f7b\u5316\u7597\u7684\u4e0d\u826f\u53cd\u5e94[41]\u3002\u7136\u800c\uff0c\u6211\u4eec\u56e2\u961f\u968f\u540e\u8fdb\u884c\u7684\u53e6\u4e00\u9879\u5173\u4e8e\u2162~\u2163\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4f7f\u7528HVC\u7684\u4e34\u5e8a\u7814\u7a76\u53d1\u73b0\uff0c\u7531\u4e8eNSCLC\u7684\u9ad8\u5f02\u8d28\u6027\uff0cHVC\u5728NSCLC\u60a3\u8005\u4e2d\u7684\u8f85\u52a9\u6cbb\u7597\u4f5c\u7528\u5dee\u5f02\u663e\u8457\uff0c\u90e8\u5206\u60a3\u8005\u5bf9HVC\u7684\u6cbb\u7597\u5e94\u7b54\u7387\u8f83\u597d\uff0c\u80bf\u7624\u7f29\u5c0f\uff0cPFS\u548cOS\u663e\u8457\u5ef6\u957f\uff0c\u4f46\u662f\u4e5f\u6709\u90e8\u5206\u60a3\u8005\u65e0\u5e94\u7b54\u751a\u81f3\u80bf\u7624\u8fdb\u5c55\uff0c\u63d0\u793a\u6709\u8f83\u5927\u7684\u4e2a\u4f53\u5dee\u5f02[7,42]\u3002\u56e0\u6b64\uff0cHVC\u5373\u4fbf\u662f\u4f5c\u4e3a\u4e00\u79cd\u8f85\u52a9\u6cbb\u7597\u4e5f\u5e76\u4e0d\u9002\u5408\u6240\u6709\u60a3\u8005[10]\u3002\u00a0\u6211\u4eec\u8fdb\u884c\u7684\u53e6\u4e00\u9879\u7814\u7a76[43]\u5229\u7528RNA-seq\u6280\u672f\u63a2\u7d22VitC\u5904\u7406\u540eH1229\u4e0ePC9\u7ec6\u80de\u4e2d\u57fa\u56e0\u8868\u8fbe\u8c31\u7684\u5dee\u5f02\uff0c\u7ed3\u679c\u663e\u793a\uff0cVitC\u80fd\u4e0b\u8c03SERPINE1\u4e0eSERPINB7\u7684\u8868\u8fbe\uff0c\u8fdb\u4e00\u6b65\u5bf9\u8fd9\u4e9b\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u8fdb\u884c\u4e86KEGG\u901a\u8def\u5bcc\u96c6\u5206\u6790\uff0c\u53d1\u73b0\u4e0a\u8ff0\u57fa\u56e0\u4e3b\u8981\u6d89\u53ca\u7ec6\u80de\u5468\u671f\u3001DNA\u590d\u5236\u4e0e\u4fee\u590d\u53ca\u5176\u4ed6\u91cd\u8981\u7ec6\u80de\u4fe1\u53f7\u901a\u8def\uff0c\u5982P53\u4fe1\u53f7\u901a\u8def\u7b49\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u8fdb\u884c\u9a8c\u8bc1\uff0c\u6211\u4eec\u56e2\u961f\u5bf9\u672c\u9662\u80bf\u7624\u4e2d\u5fc3153\u540dNSCLC\u60a3\u8005\u8fdb\u884c\u4e86\u56de\u987e\u6027\u7814\u7a76\u3002\u5176\u4e2d\uff0c81\u540d\u63a5\u53d7\u5e38\u89c4\u6297\u80bf\u7624\u6cbb\u7597\uff08\u624b\u672f\u3001\u653e\u7597\u3001\u5316\u7597\u3001\u9776\u5411\u6cbb\u7597\u3001\u514d\u75ab\u6cbb\u7597\uff09\u7684\u60a3\u8005\u4e3a\u5bf9\u7167\u7ec4\uff1b72\u540d\u5728\u63a5\u53d7\u76f8\u540c\u7684\u6297\u80bf\u7624\u6cbb\u7597\u540c\u65f6\u8054\u5408HVC\u6cbb\u7597[\u6cbb\u7597\u5242\u91cf\uff1a1 g\/\uff08kg\u00b7d\uff09\uff0c\u6bcf\u54683\u6b21\uff0c\u6cbb\u7597\u6b21\u6570\u4e3a15~30\u6b21]\u7684\u60a3\u8005\u4e3a\u6cbb\u7597\u7ec4\u3002\u7ed3\u679c\u63d0\u793a\u6cbb\u7597\u7ec4\u60a3\u8005\u7684PFS\u53caOS\u76f8\u6bd4\u5bf9\u7167\u7ec4\u663e\u8457\u5ef6\u957f\u3002\u968f\u540e\u5c06\u4e24\u7ec4\u60a3\u8005\u7684\u80bf\u7624\u7ec4\u7ec7\u8fdb\u884c\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u5206\u6790\uff0c\u5e76\u8fdb\u884cSERPINE1\u548cSERPINB7\u86cb\u767d\u7684\u8868\u8fbe\u4e0e\u751f\u5b58\u65f6\u95f4\u7684\u5206\u6790\uff0c\u6839\u636e\u86cb\u767d\u8868\u8fbe\u7684\u4e2d\u4f4d\u6c34\u5e73\u5c06\u5176\u5206\u7c7b\u4e3a\u201c\u9ad8\u8868\u8fbe\u201d\u548c\u201c\u4f4e\u8868\u8fbe\u201d\u3002\u5bf9\u7167\u7ec4\u4e2dSERPINE1\u548cSERPINB7\u7684\u4f4e\u8868\u8fbe\u60a3\u8005\u663e\u793a\u51fa\u8f83\u957f\u7684OS\uff0c\u800c\u4e24\u7ec4\u7684\u9ad8\u8868\u8fbe\u60a3\u8005\u5219\u663e\u793a\u51fa\u8f83\u77ed\u7684OS\u3002\u4ee5\u4e0a\u7ed3\u679c\u4e0eK-M Plotter\u53caHPA\u5728\u7ebf\u6570\u636e\u5e93\uff08http:\/\/kmplot.com\/analysis\/\u3001http:\/\/www.proteinatlas.org\uff09\u5206\u6790\u4e0a\u8ff0\u57fa\u56e0\u4e0eNSCLC\u60a3\u8005\u751f\u5b58\u671f\u76f8\u5173\u6027\u7684\u7ed3\u679c\u4e00\u81f4\u3002\u7136\u800c\uff0cHVC\u6cbb\u7597\u7ec4\u5219\u663e\u793a\u76f8\u53cd\u7684\u7ed3\u679c\uff0cSERPINE1\u548cSERPINB7\u9ad8\u8868\u8fbe\u7684\u60a3\u8005\u663e\u793a\u51fa\u66f4\u957f\u7684OS\u3002\u63d0\u793a\u5728SERPINE1\u548cSERPINB7\u9ad8\u8868\u8fbe\u7ec4\u7684\u60a3\u8005\u4e2d\uff0cHVC\u6cbb\u7597\u80fd\u5e26\u6765\u66f4\u663e\u8457\u7684\u76ca\u5904\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7ed3\u679c\uff0c\u6211\u4eec\u63d0\u51fa\u4e00\u4e2a\u5047\u8bbe\uff0c\u5373SERPINE1\u548cSERPINB7\u7684\u8868\u8fbe\u6c34\u5e73\u53ef\u80fd\u4f5c\u4e3a\u9884\u6d4bNSCLC\u60a3\u8005\u5bf9HVC\u6cbb\u7597\u6548\u679c\u7684\u6f5c\u5728\u6807\u5fd7\u7269\u3002\u672a\u6765\u8fd8\u9700\u8981\u8fdb\u884c\u524d\u77bb\u6027\u7684\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u8bc4\u4f30\u8fd9\u4e9b\u751f\u7269\u6807\u5fd7\u7269\u5728\u60a3\u8005\u5206\u5c42\u548c\u9884\u6d4bHVC\u6cbb\u7597\u6548\u679c\u4e2d\u7684\u5b9e\u9645\u4ef7\u503c\u3002\u540c\u65f6\uff0c\u4e5f\u8981\u8fdb\u884c\u76f8\u5173\u7684\u673a\u5236\u7814\u7a76\u4ee5\u786e\u5b9a\u5176\u4e0eHVC\u7597\u6548\u4e4b\u95f4\u7684\u5173\u8054\u6027\u6216\u56e0\u679c\u5173\u7cfb\u3002\u5982\u679c\u672a\u6765\u7684\u7814\u7a76\u80fd\u591f\u5bf9\u76ee\u524d\u7684\u7814\u7a76\u7ed3\u679c\u8fdb\u884c\u9a8c\u8bc1\uff0c\u5c06\u4e3aNSCLC\u60a3\u8005\u627e\u5230\u4e00\u79cd\u65b0\u7684\u3001\u6709\u6548\u7684\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u6709\u529b\u7684\u4f9d\u636e\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u00a0<\/p>\n<h3 class=\"wp-block-heading\"><strong>5&nbsp;&nbsp; HVC\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94<\/strong><\/h3>\n<h4 class=\"wp-block-heading\">5.1&nbsp;&nbsp; \u80be\u810f\u635f\u4f24<\/h4>\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-vivid-red-color\">HVC\u4f1a\u5bfc\u81f4\u80be\u810f\u8349\u9178\u76d0\u6c89\u79ef\uff0c\u589e\u52a0\u6025\u6027\u80be\u635f\u4f24\u53ca\u80be\u7ed3\u77f3\u7684\u98ce\u9669\u3002\u8349\u9178\u76d0\u662fVitC\u4ee3\u8c22\u7684\u526f\u4ea7\u7269\uff0c\u5f53\u5176\u5728\u4f53\u5185\u79ef\u7d2f\u65f6\uff0c\u5bb9\u6613\u5728\u80be\u810f\u4e2d\u5f62\u6210\u7ed3\u6676\uff0c\u8fdb\u800c\u5f15\u53d1\u80be\u529f\u80fd\u969c\u788d[44]\u3002\u5076\u6709\u75c5\u4f8b\u62a5\u9053\u67d0\u4e9b\u60a3\u8005\u5728\u63a5\u53d7HVC\u6cbb\u7597\u540e\uff0c\u51fa\u73b0\u4e86\u6025\u6027\u80be\u529f\u80fd\u4e0d\u5168[45]\u3002\u56e0\u6b64\uff0c\u5728\u4e34\u5e8a\u4f7f\u7528HVC\u8fc7\u7a0b\u4e2d\uff0c\u5e94\u5bc6\u5207\u76d1\u6d4b\u80be\u529f\u80fd\uff0c\u4ee5\u51cf\u5c11\u6f5c\u5728\u7684\u80be\u810f\u635f\u4f24\u98ce\u9669\u3002\u00a0<\/mark><\/p>\n<h4 class=\"wp-block-heading\">5.2&nbsp;&nbsp; \u5176\u4ed6\u4e0d\u826f\u53cd\u5e94<\/h4>\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-vivid-red-color\">HVC\u5982\u679c\u5e94\u7528\u5728\u8461\u8404\u7cd6-6-\u78f7\u9178\u8131\u6c22\u9176\uff08G6PD\uff09\u7f3a\u4e4f\u7684\u4eba\u7fa4\u4e2d\uff0c\u4f1a\u5bfc\u81f4\u6eb6\u8840\u6027\u8d2b\u8840\u3002\u8fd9\u662f\u7531\u4e8eHVC\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u8fc7\u6c27\u5316\u6c22\uff0c\u4f1a\u7834\u574f\u7ea2\u7ec6\u80de\uff0c\u5f15\u8d77\u6eb6\u8840[46]\u3002\u53e6\u5916\uff0cHVC\u8fd8\u53ef\u80fd\u5e72\u6270\u67d0\u4e9b\u68c0\u6d4b\u6570\u503c\u7684\u51c6\u786e\u6027\u3002\u4f8b\u5982\uff0cHVC\u53ef\u80fd\u5e72\u6270\u672b\u68a2\u8840\u7cd6\u4eea\u7684\u51c6\u786e\u6027\uff0c\u5bfc\u81f4\u7cd6\u5c3f\u75c5\u60a3\u8005\u672b\u68a2\u8840\u7cd6\u5047\u6027\u589e\u9ad8\u3002\u56e0\u6b64\uff0c\u9488\u5bf9\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684HVC\u4f7f\u7528\u5e94\u5c24\u5176\u6ce8\u610f[47]\u3002\u00a0<\/mark><\/p>\n<p class=\"wp-block-paragraph\">\n<h3 class=\"wp-block-heading\"><strong>6&nbsp;&nbsp; \u672a\u6765\u7684\u5c55\u671b<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">\u5c3d\u7ba1HVC\u5728\u80bf\u7624\u60a3\u8005\u4e2d\u7684\u5e94\u7528\u4e00\u76f4\u5907\u53d7\u5b66\u754c\u7684\u4e89\u8bae\uff0c\u4f46\u8d8a\u6765\u8d8a\u591a\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cVitC\u5177\u6709\u591a\u79cd\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u5176\u591a\u79cd\u4f5c\u7528\u673a\u5236\u4e0d\u662f\u72ec\u7acb\u5b58\u5728\uff0c\u800c\u662f\u76f8\u4e92\u8054\u7cfb\u3002\u540c\u65f6\uff0c\u7531\u4e8eHVC\u5bf9\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u7684\u6cbb\u7597\u6548\u679c\u5dee\u5f02\u663e\u8457\uff0c\u56e0\u6b64\uff0cHVC\u4e0d\u5e94\u4f5c\u4e3a\u4e00\u79cd\u201c\u4e00\u5200\u5207\u201d\u7684\u6cbb\u7597\u65b9\u5f0f\u88ab\u5e94\u7528\u3002\u4eca\u540e\u9700\u8bbe\u8ba1\u66f4\u591a\u5927\u6837\u672c\u3001\u524d\u77bb\u6027\u968f\u673a\u5bf9\u7167\u7814\u7a76\uff0c\u63a2\u8ba8\u5bf9HVC\u654f\u611f\u7684\u80bf\u7624\u7c7b\u578b\u53ca\u751f\u7269\u6807\u5fd7\u7269\uff0c\u66f4\u6df1\u5165\u5730\u7814\u7a76\u5176\u4e0e\u5e38\u89c4\u6297\u80bf\u7624\u6cbb\u7597\u8054\u5408\u4f7f\u7528\u7684\u65f6\u673a\u3001\u9891\u7387\u3001\u5468\u671f\u7b49\u95ee\u9898\uff0c\u4e3a\u4e34\u5e8a\u7684\u5e94\u7528\u63d0\u4f9b\u66f4\u591a\u3001\u66f4\u9ad8\u7ea7\u522b\u7684\u8bc1\u636e\u3002\uff08\u53c2\u8003\u6587\u732e\u89c1\u9605\u8bfb\u539f\u6587\uff09<\/p>\n<p class=\"wp-block-paragraph\"><em><strong>\u672c\u6587\u4e3a\u300a\u80bf\u7624\u9632\u6cbb\u7814\u7a76\u300b\u539f\u521b\uff0c\u8f6c\u8f7d\u8bf7\u6ce8\u660e\u4f5c\u8005\u548c\u6765\u6e90<\/strong><\/em><\/p>\n<p class=\"wp-block-paragraph\"><em><strong>\u7f16\u8f91\uff1aJack<\/strong><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u539f\u6587\u94fe\u63a5 \u539f\u521b \u533a\u4fca\u6587 \u80bf\u7624\u9632\u6cbb\u7814\u7a76 2025\u5e742\u67086\u65e5 \u6765\u6e90\uff1a\u80bf\u7624\u9632\u6cbb\u7814\u7a76,2 &hellip; <a href=\"http:\/\/zydq.1006ss.com\/?p=67514\">\u7ee7\u7eed\u9605\u8bfb <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[194],"class_list":["post-67514","post","type-post","status-publish","format-standard","hentry","category-70","tag-194"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/67514","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=67514"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/67514\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=67514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=67514"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=67514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}