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class=\"wp-block-paragraph\">N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\uff08NAC\uff09\u662fL-\u534a\u80f1\u6c28\u9178\u7684\u884d\u751f\u7269\uff0c\u662f\u4e00\u79cd\u6210\u719f\u7684\u9ecf\u6db2\u6eb6\u89e3\u5242\u3001\u6297\u6c27\u5316\u5242\u548c\u6297\u708e\u5242\uff0c\u5e38\u7528\u4e8e\u6025\u6027\u548c\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u7ba1\u7406\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b1-dic-2025-7-7\">\u6700\u521d<\/a>\u4f5c\u4e3a\u9ecf\u6db2\u6eb6\u89e3\u5242\u5f00\u53d1\uff0c\u5176\u8fd8\u80fd\u51cf\u5c11\u9ecf\u6db2\u7cd6\u86cb\u767d\u4e2d\u7684\u4e8c\u786b\u952e\uff0c\u4fc3\u8fdb\u5206\u6ccc\u7269\u6e05\u9664\uff0c\u6539\u5584\u9ecf\u6db2\u529f\u80fd\u548c\u6c14\u9053\u901a\u7545\u6027\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b2-dic-2025-7-7\">\u9664\u4e86<\/a>\u76f4\u63a5\u7684\u9ecf\u6db2\u6eb6\u89e3\u6d3b\u6027\u5916\uff0cNAC\u8fd8\u589e\u5f3a\u7c98\u6db2\u8fd0\u8f93<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b3-dic-2025-7-7\">3<\/a>\uff0c\u5e76\u5728\u4e0a\u76ae\u5c42\u9762\u8c03\u8282\u7c98\u6db2\u751f\u6210\uff0c\u7a81\u51fa\u5176\u7ed3\u5408\u7684\u9ecf\u6db2\u6eb6\u89e3\u548c\u9ecf\u6db2\u8c03\u8282\u7279\u6027\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b4-dic-2025-7-7\">4<\/a>&nbsp;NAC\u8fd8\u4fc3\u8fdb\u8c37\u80f1\u7518\u80bd\u5408\u6210\uff0c\u63d0\u4f9b\u6297\u6c27\u5316\u4fdd\u62a4\uff0c\u9632\u6b62\u6c27\u5316\u5e94\u6fc0\u5f15\u8d77\u7684\u80ba\u635f\u4f24\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b2-dic-2025-7-7\">\u6b64\u5916<\/a>\uff0cNAC\u901a\u8fc7\u6291\u5236NF-\u03baB\u6fc0\u6d3b\u548c\u795e\u7ecf\u6fc0\u80bdA\u91ca\u653e\uff0c\u8c03\u8282\u708e\u75c7\u901a\u8def\uff0c\u4ece\u800c\u51cf\u5c11\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b5-dic-2025-7-7\">5<\/a>\u2013<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b8-dic-2025-7-7\">8<\/a><\/p>\n<p class=\"wp-block-paragraph\">NAC\u901a\u8fc7\u7834\u574f\u751f\u7269\u819c\u5e76\u53d1\u6325\u76f4\u63a5\u6297\u83cc\u4f5c\u7528\uff0c\u589e\u5f3a\u6297\u751f\u7d20\u7684\u7597\u6548\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b10-dic-2025-7-7\">9,10<\/a>&nbsp;\u4f53\u5916\uff0cNAC\u534f\u540c\u589e\u5f3a\u6297\u751f\u7d20\u5bf9\u6297\u591a\u836f\u8010\u836f\u7ec6\u83cc\uff0c\u5305\u62ec\u9c8d<em>\u66fc\u4e0d\u52a8\u6746<\/em>\u83cc\u548c<em>\u80ba\u708e\u514b\u96f7\u4f2f<\/em>\u83cc\uff0c\u901a\u8fc7\u6539\u53d8\u7ec6\u83cc\u5f62\u6001\u589e\u5f3a\u809d\u83cc\u6d3b\u6027\u5e76\u589e\u5f3a\u03b2-\u5185\u9170\u80fa\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b9-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b9-dic-2025-7-7\"><\/a>9,11,12 \u5b83\u8fd8\u80fd\u63d0\u5347\u9752\u9709\u7d20\u5bf9\u67d0\u4e9b\u9769\u5170\u6c0f\u9634\u6027\u75c5\u539f\u4f53\u7684\u7597\u6548<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b13-dic-2025-7-7\">\uff0c\u5e76\u7834\u574f<\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b11-dic-2025-7-7\"><\/a><em>\u91d1\u9ec4\u8272\u8461\u8404\u7403<\/em>\u83cc\u751f\u7269\u819c\uff0c\u6297\u751f\u7d20\u53ef\u5b9e\u73b0\u226590%\u7684\u964d\u4f4e\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b12-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b14-dic-2025-7-7\">14<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u5728\u4f53\u5185\uff0cNAC\u80fd\u51cf\u8f7b\u611f\u67d3\u76f8\u5173\u7684\u5668\u5b98\u635f\u4f24\u548c\u708e\u75c7\uff0c\u6539\u5584\u6297\u83cc\u6548\u679c\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b15-dic-2025-7-7\">15<\/a>\u2013<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b17-dic-2025-7-7\">17<\/a>\u00a0\u4e34\u5e8a\u7814\u7a76\u5c06NAC\u4e0e\u591a\u91cd\u8010\u836f<em>\u6027\u80ba\u708e\u514b\u96f7\u4f2f<\/em>\u6c0f\u83cc\u548c<em>\u9c8d\u66fc\u4e0d<\/em>\u52a8\u6746\u83cc\u611f\u67d3\u4e2d30\u5929\u6b7b\u4ea1\u7387\u964d\u4f4e\u5173\u8054\u8d77\u6765\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b11-dic-2025-7-7\">11<\/a>\u00a0Blasi \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b10-dic-2025-7-7\">\u4eba\u5f3a\u8c03\u5176<\/a>\u5728\u547c\u5438\u9053\u611f\u67d3\u4e2d\u7684\u4f5c\u7528\uff0c<mark class=\"has-inline-color has-vivid-red-color\">\u7279\u522b\u662f\u5728\u6162\u6027\u652f\u6c14\u7ba1\u708e\u3001\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\uff08COPD\uff09\u548c\u56ca\u6027\u7ea4\u7ef4\u5316\uff08CF\uff09\u4e2d\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b10-dic-2025-7-7\">10<\/a>\u9879\u513f\u79d1\u7814\u7a76\u8868\u660e\uff0cNAC\u4e0e\u6297\u751f\u7d20\u8054\u5408\u4f7f\u7528\u65f6\u80fd\u52a0\u901f\u5eb7\u590d\u3002<\/mark><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b18-dic-2025-7-7\">18<\/a>\u2013<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b21-dic-2025-7-7\">21<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u673a\u5236\u5171\u540c\u4fc3\u8fdb\u4e86NAC\u7684\u6574\u4f53\u6cbb\u7597\u6548\u679c\uff0c\u8868\u660e\u5176\u76ca\u5904\u8d85\u8d8a\u4e86\u4f20\u7edf\u6eb6\u9ecf\u5242\u7684\u89d2\u8272\uff0c\u800c\u662f\u7531\u591a\u91cd\u9ecf\u6db2\u8c03\u8282\u3001\u6297\u611f\u67d3\u3001\u6297\u6c27\u5316\u548c\u6297\u708e\u4f5c\u7528\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u679c\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b1-dic-2025-7-7\">1<\/a>&nbsp;\u5728\u513f\u79d1\u4eba\u7fa4\u4e2d\uff0cNAC\u5e38\u7528\u4e8e\u652f\u6c14\u7ba1\u708e\u3001\u7ec6\u652f\u6c14\u7ba1\u708e\u3001\u80ba\u708e\u548c\u56ca\u6027\u7ea4\u7ef4\u5316\u7b49\u75be\u75c5\u3002\u7136\u800c\uff0c\u5176\u7597\u6548\u548c\u5b89\u5168\u6027\u56e0\u5e74\u9f84\u7ec4\u3001\u914d\u65b9\u548c\u7ed9\u836f\u9014\u5f84\u800c\u5f02\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u5242\u91cf\u5efa\u8bae\u4e5f\u53ef\u80fd\u56e0\u4ea7\u54c1\u6388\u6743\u7684\u56fd\u5bb6\u800c\u5f02\u3002\u4e00\u4e9b\u56fd\u5bb6\u5efa\u8bae\u4ece2\u5c81\u8d77\u7ef4\u6301\u76f8\u540c\u5242\u91cf\uff0c\u800c\u53e6\u4e00\u4e9b\u56fd\u5bb6\u5219\u8bbe\u5b9a6\u81f37\u5c81\u7684\u622a\u6b62\u5e74\u9f84\u4ee5\u589e\u52a0\u5242\u91cf\u3002\u7136\u800c\uff0c\u7531\u4e8e\u4f53\u91cd\u57282\u81f36\u81f37\u5e74\u4e4b\u95f4\u5dee\u5f02\u663e\u8457\uff0c6\u81f37\u81f312\u5e74\u4e4b\u95f4\u5dee\u5f02\u663e\u8457\uff0c\u8fd9\u4e9b\u57fa\u4e8e\u5e74\u9f84\u7684\u5e7f\u6cdb\u5242\u91cf\u7c7b\u522b\u53ef\u80fd\u5bfc\u81f4\u6cbb\u7597\u6548\u679c\u4e0d\u4f73\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u5b9e\u65bd\u66f4\u7cbe\u51c6\u3001\u9002\u9f84\u548c\u8c03\u6574\u4f53\u91cd\u7684\u5242\u91cf\u65b9\u6848\uff0c\u53ef\u4ee5\u8fdb\u4e00\u6b65\u4f18\u5316\u836f\u7269\u7684\u7597\u6548\u548c\u8010\u53d7\u6027\u3002\u867d\u7136\u53e3\u670d\u548c\u5438\u5165\u6027\u9ecf\u6db2\u6eb6\u89e3\u5242\u5728\u8f83\u5927\u513f\u7ae5\u4e2d\u5b89\u5168\u6027\u8f83\u4f73\uff0c\u4f46\u7531\u4e8e\u6709\u53cd\u5411\u6027\u652f\u6c14\u7ba1\u3001\u6c14\u9053\u963b\u585e\u548c\u547c\u5438\u56f0\u96be\u7684\u62a5\u544a\uff0c\u4e0d\u5efa\u8bae\u57282\u5c81\u4ee5\u4e0b\u5a74\u513f\u4e2d\u4f7f\u7528\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b22-dic-2025-7-7\">\u6b64\u5916<\/a>\uff0c\u8fd9\u4e9b\u836f\u7269<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b23-dic-2025-7-7\"><\/a>\u8fd8\u53ef\u80fd\u5bfc\u81f42\u5c81\u4ee5\u4e0b\u513f\u7ae5\u652f\u6c14\u7ba1\u5206\u6ccc\u7269\u589e\u52a0\uff0c\u60a3\u8005\u53ef\u80fd\u96be\u4ee5\u901a\u8fc7\u54b3\u55fd\u6392\u51fa\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b24-dic-2025-7-7\">24<\/a>&nbsp;\u8fd9\u4e9b\u62c5\u5fe7\u5bfc\u81f4\u4e00\u4e9b\u56fd\u5bb6\u5b9e\u65bd\u4e86\u76d1\u7ba1\u9650\u5236\uff0c\u51f8\u663e\u4e86\u6781\u5e74\u8f7b\u513f\u79d1\u4eba\u7fa4\u7684\u7279\u6b8a\u8106\u5f31\u6027\uff0c\u4ee5\u53ca\u533b\u5b66\u754c\u6301\u7eed\u5173\u6ce8\u6700\u4f73\u5242\u91cf\u7684\u91cd\u8981\u6027\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u9274\u4e8e\u5176\u826f\u597d\u7684\u8010\u53d7\u6027\uff0cNAC\u5728\u7ba1\u7406\u513f\u7ae5\u9ecf\u6db2\u5206\u6ccc\u8fc7\u591a\u65b9\u9762\u5c55\u73b0\u51fa\u6f5c\u529b\uff0c\u5c24\u5176\u662f\u5728\u6025\u6027\u611f\u67d3\u4e2d\uff0c\u8fd9\u7c7b\u611f\u67d3\u5728\u8be5\u5e74\u9f84\u6bb5\u975e\u5e38\u666e\u904d\u3002\u672c\u53d9\u8ff0\u7efc\u8ff0\u7efc\u5408\u4e86NAC\u5728\u513f\u79d1\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u4e2d\u7684\u73b0\u6709\u8bc1\u636e\uff0c\u6db5\u76d6\u5176\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u4f5c\u7528\u673a\u5236\u3001\u4e34\u5e8a\u7597\u6548\u548c\u5b89\u5168\u6027\u8003\u91cf\uff0c\u540c\u65f6\u8003\u8651\u57fa\u4e8e\u4f53\u91cd\u7684\u5242\u91cf\u65b9\u6848\u3002\u901a\u8fc7\u8bc4\u4f30\u5bf9\u7167\u8bd5\u9a8c\u3001\u89c2\u5bdf\u6027\u7814\u7a76\u548c\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\u7684\u6570\u636e\uff0c\u6211\u4eec\u65e8\u5728\u6f84\u6e05NAC\u5728\u513f\u79d1\u547c\u5438\u62a4\u7406\u4e2d\u7684\u4f5c\u7528\uff0c\u5e76\u8bc6\u522b\u672a\u6765\u7814\u7a76\u7684\u7a7a\u767d\u3002<\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>\u65b9\u6cd5<\/h2>\n<p class=\"wp-block-paragraph\">\u8fd9\u662f\u4e00\u7bc7\u5173\u4e8e\u4f7f\u7528PubMed\/MEDLINE\u548cGoogle Scholar\u8fdb\u884c\u6587\u732e\u7684\u53d9\u8ff0\u6027\u7efc\u8ff0\u3002\u6587\u732e\u68c0\u7d22\u4e2d\u4f7f\u7528\u4e86\u4ee5\u4e0b\u5173\u952e\u8bcd\uff1a\uff08\u201cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u201d\u548c\u201c\u836f\u4ee3\u52a8\u529b\u5b66\u201d\uff09\u6216\uff08\u201cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u201d\u548c\u201c\u4f5c\u7528\u673a\u5236\u201d\uff09\u6216\uff08\u201cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u201d\u548c\u201c\u6297\u708e\u201d\uff09\u6216\uff08\u201cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u201d\u548c\u201c\u6297\u6c27\u5316\u201d\uff09\u6216\uff08\u201cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u201d\u548c\u201c\u7ec6\u80de\u4fdd\u62a4\u6027\u201d\uff09\u6216\uff08\u201cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u201d\u548c\u201c\u513f\u7ae5\u201d\u548c\u201c\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u201d\uff09\u3002\u68c0\u7d22\u6db5\u76d6\u4e861964\u5e741\u6708\u81f32025\u5e746\u6708\u7684\u65f6\u95f4\u6bb5\uff0c\u7b26\u5408\u6700\u65e9\u7684\u7814\u7a76\u548c\u6700\u65b0\u7684\u8bc1\u636e\u3002\u6587\u7ae0\u6700\u521d\u6309\u6807\u9898\u548c\u6458\u8981\u7b5b\u9009\u76f8\u5173\u6027\uff0c\u968f\u540e\u8fdb\u884c\u5168\u6587\u7efc\u8ff0\u3002\u6b64\u5916\uff0c\u8fd8\u5ba1\u67e5\u4e86\u90e8\u5206\u6587\u7ae0\u7684\u53c2\u8003\u6587\u732e\u5217\u8868\uff0c\u4ee5\u8bc6\u522b\u66f4\u591a\u76f8\u5173\u6587\u732e\u3002<\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>NAC\u7684\u836f\u4ee3\u52a8\u529b\u5b66<\/h2>\n<p class=\"wp-block-paragraph\">NAC\u662f\u5929\u7136\u6c28\u57fa\u9178L-\u534a\u80f1\u6c28\u9178\u7684\u5408\u6210\u884d\u751f\u7269\uff0c\u5176\u7279\u5f81\u662f\u786b\u9187\u57fa\u56e2\uff0c\u662f\u8c37\u80f1\u7518\u80bd\u5408\u6210\u7684\u524d\u4f53\uff0c\u8c37\u80f1\u7518\u80bd\u662f\u7ec6\u80de\u9632\u5fa1\u673a\u5236\u4e2d\u7684\u5173\u952e\u6297\u6c27\u5316\u5242\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b25-dic-2025-7-7\">25<\/a>&nbsp;NAC\u53ef\u53e3\u670d\u3001\u9759\u8109\u6ce8\u5c04\u6216\u5438\u5165\uff0c\u6bcf\u79cd\u9014\u5f84\u5bf9\u5176\u836f\u4ee3\u52a8\u529b\u5b66\u5f71\u54cd\u4e0d\u540c\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b2-dic-2025-7-7\">2<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u5438\u5165\u5f0fNAC\u53ef\u80fd\u8fbe\u5230\u66f4\u9ad8\u7684\u6c14\u9053\u6d53\u5ea6\uff0c\u4ece\u800c\u53ef\u80fd\u589e\u5f3a\u5176\u9ecf\u6db2\u6eb6\u89e3\u6548\u679c\u3002\u7136\u800c\uff0c\u5176\u96fe\u5316\u5f62\u5f0f\u7684\u5e7f\u6cdb\u5e94\u7528\u53d7\u9650\u4e8e\u5176\u5185\u5728\u8fd8\u539f\u6d3b\u6027\u4f4e\u4e14\u6c14\u9053\u534a\u8870\u671f\u8f83\u77ed\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u5bf9\u4e8e\u547c\u5438\u7cfb\u7edf\u75be\u75c5\uff0c\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u6210\u4eba\u7684\u65e5\u5e38\u53e3\u670d\u5242\u91cf\u8303\u56f4\u4e3a600\u81f31200\u6beb\u514b\uff0c\u5c3d\u7ba1\u6839\u636e\u4e34\u5e8a\u80cc\u666f\u4e5f\u66fe\u8003\u8651\u8fc7\u66f4\u9ad8\u5242\u91cf\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b26-dic-2025-7-7\">26<\/a>\u2013<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b31-dic-2025-7-7\">31<\/a>\u00a0<mark class=\"has-inline-color has-vivid-red-color\">\u53e3\u670d\u540e\uff0cNAC\u5728\u5c0f\u80a0\u8fc5\u901f\u5438\u6536\uff0c1\u20132\u5c0f\u65f6\u5185\u8fbe\u5230\u8840\u6d46\u6d53\u5ea6\u5cf0\u503c\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b32-dic-2025-7-7\">32,33<\/a>\u00a0NAC\u5728\u809d\u810f\u4e2d\u7ecf\u5386\u5e7f\u6cdb\u7684\u7b2c\u4e00\u8fc7\u4ee3\u8c22\uff0c\u4e3b\u8981\u8f6c\u5316\u4e3aL-\u534a\u80f1\u6c28\u9178\uff0c\u968f\u540e\u7528\u4e8e\u8c37\u80f1\u7518\u80bd\u5408\u6210\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b33-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b25-dic-2025-7-7\">25<\/a>\u00a0\u53e3\u670d400\u6beb\u514bNAC\u540e\uff0c\u7ec8\u672b\u534a\u8870\u671f\u7ea6\u4e3a6\u5c0f\u65f6\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b34-dic-2025-7-7\">\u7531\u4e8e<\/a>\u8fd9\u79cd\u9996\u8fc7\u6548\u5e94\u548c\u7ec6\u80de\u5feb\u901f\u5438\u6536\uff0cNAC\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u663e\u8457\u8f83\u4f4e\uff0c\u8303\u56f4\u57284%\u523010%\u4e4b\u95f4\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b35-dic-2025-7-7\"><\/a>\u00a0<\/mark><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b34-dic-2025-7-7\">34,35<\/a><\/p>\n<p class=\"wp-block-paragraph\">NAC\u7684\u6d88\u9664\u534a\u8870\u671f\u56e0\u7ed9\u836f\u9014\u5f84\u548c\u60a3\u8005\u7fa4\u4f53\u800c\u5f02\u3002\u9759\u8109\u6ce8\u5c04\u7ed5\u8fc7\u809d\u810f\u548c\u80a0\u58c1\u7684\u9996\u6b21\u4ee3\u8c22\uff0c\u4f7f\u836f\u7269\u80fd\u66f4\u5feb\u83b7\u5f97\u6cbb\u7597\u6d53\u5ea6\uff0c\u8fd9\u5728\u5bf9\u4e59\u9170\u6c28\u57fa\u915a\u4e2d\u6bd2\u4e2d\u53ef\u89c1\u4e00\u6591\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b36-dic-2025-7-7\">36<\/a>&nbsp;\u5728\u5065\u5eb7\u6210\u4eba\u4e2d\uff0c\u9759\u8109\u6ce8\u5c04NAC\uff08600\u6beb\u514b\uff09\u7684\u7ec8\u672b\u534a\u8870\u671f\u7ea6\u4e3a2.3\u5c0f\u65f6\uff0c12\u5c0f\u65f6\u540e\u51e0\u4e4e\u68c0\u6d4b\u4e0d\u5230\u8840\u6d46\u6c34\u5e73\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b35-dic-2025-7-7\">35<\/a><\/p>\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-vivid-red-color\">NAC\u4e3b\u8981\u901a\u8fc7\u80be\u810f\u6392\u51fa\uff0c\u7ea630%\u7684\u5242\u91cf\u901a\u8fc7\u5c3f\u6db2\u56de\u6536\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b35-dic-2025-7-7\">35<\/a>\uff0c\u7caa\u4fbf\u6392\u6cc4\u7ea6\u53603%\u3002<\/mark><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b37-dic-2025-7-7\">2.37<\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b2-dic-2025-7-7\"><\/a><\/p>\n<p class=\"wp-block-paragraph\">\u5728\u513f\u79d1\u60a3\u8005\u4e2d\uff0c\u4e0e\u6210\u4eba\u76f8\u6bd4\uff0c\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\u7684\u5dee\u5f02\u9700\u8981\u8c03\u6574\u5242\u91cf\u4ee5\u786e\u4fdd\u836f\u7269\u6700\u4f73\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b39-dic-2025-7-7\"><\/a>&nbsp;<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b38-dic-2025-7-7\">38,39<\/a><\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>NAC\u7684\u4f5c\u7528\u673a\u5236<\/h2>\n<p class=\"wp-block-paragraph\">NAC\u901a\u8fc7\u591a\u79cd\u673a\u5236\u53d1\u6325\u5176\u6cbb\u7597\u6548\u679c\uff0c\u4e3b\u8981\u6d89\u53ca\u5176\u9ecf\u6db2\u6eb6\u89e3\u3001\u6297\u6c27\u5316\u548c\u6297\u708e\u7279\u6027\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b40-dic-2025-7-7\">\u4f5c\u4e3a<\/a>L-\u534a\u80f1\u6c28\u9178\u7684\u4e59\u9170\u5316\u524d\u4f53\uff0cNAC\u5728\u7ef4\u6301\u7ec6\u80de\u6c27\u5316\u8fd8\u539f\u7a33\u6001\u548c\u8c03\u8282\u708e\u75c7\u901a\u8def\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b40-dic-2025-7-7\">40<\/a><\/p>\n<p class=\"wp-block-paragraph\">NAC\u56e0\u5176\u9ecf\u6db2\u6eb6\u89e3\u7279\u6027\u800c\u5e7f\u4e3a\u4eba\u77e5\uff0c\u5c24\u5176\u662f\u5728\u4ee5\u56ca\u6027\u7ea4\u7ef4\u5316\u3001\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\uff08COPD\uff09\u548c\u7279\u53d1\u6027\u80ba\u7ea4\u7ef4\u5316\u7b49\u4e3a\u7279\u5f81\u7684\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u4e2d\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b40-dic-2025-7-7\">40<\/a>&nbsp;NAC\u7684\u9ecf\u6db2\u6eb6\u89e3\u4f5c\u7528\u5177\u6709\u591a\u56e0\u7d20\u4f5c\u7528\uff0c\u7ed3\u5408\u4e86\u4fc3\u8fdb\u7c98\u6db2\u6e05\u9664\u7684\u76f4\u63a5\u548c\u95f4\u63a5\u673a\u5236\u3002\u5176\u4e3b\u8981\u7684\u9ecf\u6db2\u5206\u89e3\u4f5c\u7528\u6e90\u4e8e\u5176\u80fd\u591f\u5207\u5272\u9ad8\u5206\u5b50\u91cf\u7cd6\u86cb\u767d\uff08\u9ecf\u86cb\u767d\uff09\u4e2d\u7684\u4e8c\u786b\u952e\uff0c\u9ecf\u86cb\u767d\u8d1f\u8d23\u9ecf\u6db2\u7684\u7c98\u6027\u548c\u5f39\u6027\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b2-dic-2025-7-7\">2<\/a>&nbsp;\u708e\u75c7\u8fc7\u7a0b\u4e2d\uff0c\u9ecf\u86cb\u767d\u53d1\u751f\u6c27\u5316\u4fee\u9970\uff0c\u5bfc\u81f4\u5f02\u5e38\u7684\u4e8c\u786b\u952e\u4ea4\u8054\uff0c\u4f7f\u7c98\u6db2\u589e\u7a20\u5e76\u5f71\u54cd\u9ecf\u6db2\u6e05\u9664\u80fd\u529b\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b25-dic-2025-7-7\">25,41<\/a>&nbsp;\u901a\u8fc7\u51cf\u5c11\u786b\u9187\u57fa\u56e2\u4e2d\u7684\u4e8c\u786b\u952e\uff0cNAC\u964d\u4f4e\u7c98\u6db2\u7c98\u5ea6\uff0c\u4fc3\u8fdb\u5176\u4ece\u6c14\u9053\u4e2d\u6392\u51fa\u5e76\u6539\u5584\u6c14\u6d41\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b41-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b25-dic-2025-7-7\">25,41<\/a>&nbsp;NAC\u8fd8\u589e\u5f3a\u7c98\u6db2\u7ea4\u6bdb\u8fd0\u8f93\uff0c\u63d0\u4f9b\u53cc\u91cd\u9ecf\u6db2\u6eb6\u89e3\u4f5c\u7528\u673a\u5236\uff0c\u63d0\u5347\u5206\u6ccc\u7269\u6e05\u9664\u80fd\u529b\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b41-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b3-dic-2025-7-7\">\u6b64\u5916<\/a>\uff0c\u8bc1\u636e\u8868\u660eNAC\u901a\u8fc7\u8c03\u8282MUC5AC\u548cMUC5B\u8868\u8fbe\u5e76\u51cf\u5c11\u9ad8\u811a\u676f\u7ec6\u80de\u6570\u91cf\uff0c\u5728\u4e0a\u76ae\u5c42\u9762\u8c03\u8282\u7c98\u6db2\u751f\u6210\uff0c\u5f3a\u5316\u5176\u4f5c\u4e3a\u9ecf\u6db2\u6eb6\u89e3\u5242\u548c\u9ecf\u6db2\u8c03\u8282\u5242\u7684\u4f5c\u7528\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b4-dic-2025-7-7\">4<\/a><\/p>\n<p class=\"wp-block-paragraph\">NAC\u65e2\u662f\u76f4\u63a5\u6297\u6c27\u5316\u5242\uff0c\u4e5f\u662f\u95f4\u63a5\u6297\u6c27\u5316\u5242\u3002\u5176\u76f4\u63a5\u6297\u6c27\u5316\u4f5c\u7528\u6e90\u81ea\u5176\u786b\u9187\u57fa\u56e2\uff0c\u8be5\u57fa\u56e2\u4f1a\u6e05\u9664\u6d3b\u6027\u6c27\u548c\u6c2e\u7269\u8d28\uff0c\u5305\u62ec\u8fc7\u6c27\u5316\u6c22\u3001\u7f9f\u57fa\u81ea\u7531\u57fa\u3001\u8fc7\u6c27\u5316\u7269\u3001\u6b21\u6c2f\u9178\u548c\u4e8c\u6c27\u5316\u6c2e\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b41-dic-2025-7-7\">41<\/a>\u2013<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b45-dic-2025-7-7\">45<\/a>&nbsp;NAC\u7684\u95f4\u63a5\u6297\u6c27\u5316\u4f5c\u7528\u66f4\u4e3a\u660e\u663e\uff0c\u6d89\u53ca\u8865\u5145\u7ec6\u80de\u5185\u8c37\u80f1\u7518\u80bd\u6c34\u5e73\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b2-dic-2025-7-7\">2<\/a>&nbsp;\u8131\u4e59\u9170\u5316\u540e\uff0cNAC\u63d0\u4f9b\u534a\u80f1\u6c28\u9178\uff0c\u5373\u8c37\u80f1\u7518\u80bd\u5408\u6210\u7684\u901f\u7387\u9650\u5236\u5e95\u7269\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b46-dic-2025-7-7\">46<\/a>&nbsp;\u8c37\u80f1\u7518\u80bd\u662f\u4e00\u79cd\u5173\u952e\u7684\u6297\u6c27\u5316\u5242\uff0c\u80fd\u591f\u4e2d\u548c\u53cd\u5e94\u6027\u7269\u8d28\uff0c\u5e76\u4f5c\u4e3a\u591a\u79cd\u6297\u6c27\u5316\u9176\u7684\u5e95\u7269\uff0c\u5305\u62ec\u8c37\u80f1\u7518\u80bd\u8fc7\u6c27\u5316\u7269\u9176\u548c\u8c37\u80f1\u7518\u80bd\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b47-dic-2025-7-7\">47<\/a>&nbsp;\u901a\u8fc7\u589e\u5f3a\u8c37\u80f1\u7518\u80bd\u7684\u751f\u7269\u5408\u6210\uff0cNAC\u6062\u590d\u7ec6\u80de\u4e2d\u7684\u6c27\u5316\u8fd8\u539f\u5e73\u8861\uff0c\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u6c27\u5316\u635f\u4f24\uff0c\u5c24\u5176\u662f\u5728\u6025\u6027\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\uff08COPD\uff09\u7b49\u8c37\u80f1\u7518\u80bd\u6c34\u5e73\u4e0b\u964d\u7684\u75be\u75c5\u4e2d\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b48-dic-2025-7-7\">\u9664\u4e86<\/a>\u8c37\u80f1\u7518<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b49-dic-2025-7-7\"><\/a>\u80bd\u8865\u5145\u5916\uff0c\u8fd8\u6709\u5176\u4ed6\u673a\u5236\u88ab\u63d0\u51fa\u89e3\u91caNAC\u5728\u6c27\u5316\u8fd8\u539f\u5e73\u8861\u4e2d\u7684\u6f5c\u5728\u4f5c\u7528\uff0c\u5305\u62ec\u901a\u8fc7\u6062\u590d\u4eba\u7c7b\u8840\u6e05\u767d\u86cb\u767d\u4e2d\u7684Cys34\u6b8b\u57fa\u6765\u589e\u5f3a\u8840\u6d46\u6297\u6c27\u5316<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b50-dic-2025-7-7\">\u6d3b\u6027\uff0c\u4ee5\u53ca<\/a>\u5bf9\u7ec6\u80de\u5185\u786b\u5316\u6c22\u548c\u786b\u78fa\u7269\u79cd\u7c7b\u9002\u5ea6\u589e\u52a0\u7684\u8d21\u732e\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b51-dic-2025-7-7\">51<\/a><\/p>\n<p 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href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b6-dic-2025-7-7\">\u901a\u8fc7<\/a>\u963b\u65adNF-\u03baB\u7684\u6613\u4f4d\u548c\u6fc0\u6d3b\uff0cNAC\u6291\u5236\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u7684\u91ca\u653e\uff0c\u964d\u4f4e\u73af\u6c27\u5408\u91762\u3001\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u548c\u7ec6\u80de\u95f4\u7c98\u9644\u5206\u5b50\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u4e30\u5bcc\u5176\u5e7f\u6cdb\u7684\u6297\u708e\u7279\u6027\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b52-dic-2025-7-7\">52<\/a>&nbsp;\u6b64\u5916\uff0cNAC\u6291\u5236\u8102\u591a\u7cd6\u523a\u6fc0\u4eba\u7c7b\u652f\u6c14\u7ba1\u4e2d\u7684\u795e\u7ecf\u6fc0\u80bdA\u91ca\u653e\uff0c\u4ece\u800c\u51cf\u7f13IL-6\u7684\u589e\u52a0\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b54-dic-2025-7-7\"><\/a>&nbsp;<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b53-dic-2025-7-7\">53,54<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u9664\u4e86\u5176\u9ecf\u6db2\u6eb6\u89e3\u3001\u6297\u6c27\u5316\u548c\u6297\u708e\u4f5c\u7528\u5916\uff0cNAC\u8fd8\u901a\u8fc7\u8fd8\u539f\u80fd\u529b\u7a33\u5b9a\u86cb\u767d\u8d28\u548cDNA\uff0c\u53d1\u6325\u7ec6\u80de\u4fdd\u62a4\u4f5c\u7528\uff0c\u53ef\u80fd\u5bf9\u57fa\u56e0\u6bd2\u6027\u3001\u7ec6\u80de\u51cb\u4ea1\u548c\u6076\u6027\u8f6c\u5316\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b25-dic-2025-7-7\">25<\/a><\/p>\n<p 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href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b55-dic-2025-7-7\">55<\/a>\u4e2a\u4e0d\u540c\u56e0\u7d20\uff0c\u5982\u8fc7\u654f\u539f\u65e9\u671f\u81f4\u654f\u3001\u9891\u7e41\u75c5\u6bd2\u611f\u67d3\u4ee5\u53ca\u65e9\u4ea7\u513f\u652f\u6c14\u7ba1\u80ba\u53d1\u80b2\u4e0d\u826f\u5b58\u6d3b\u7387\u63d0\u9ad8\uff0c\u5747\u5bfc\u81f4\u547c\u5438\u7cfb\u7edf\u95ee\u9898\u590d\u53d1\uff0c\u589e\u52a0\u6025\u6027\u75be\u75c5\u8f6c\u4e3a\u6162\u6027\u75c5\u7684\u98ce\u9669\u3002\u5176\u4e2d<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b55-dic-2025-7-7\"><\/a>\u6025\u6027\u547c\u5438\u9053\u611f\u67d3\u5c24\u4e3a\u5e38\u89c1\uff0c\u5b66\u9f84\u513f\u7ae5\u6bcf\u5e74\u6709\u4e94\u5230\u516b\u6b21\u53d1\u75c5\uff0c\u6bcf\u6b21\u6301\u7eed7\u81f39\u5929\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b56-dic-2025-7-7\">56<\/a>&nbsp;\u54b3\u55fd\u662f\u4e3b\u8981\u75c7\u72b6\uff0c\u5728\u4e00\u534a\u75c5\u4f8b\u4e2d\u6301\u7eed\u8d85\u8fc710\u5929\uff0c10%\u7684\u513f\u7ae5\u6301\u7eed\u8d85\u8fc73\u5468\uff0c\u4e25\u91cd\u5e72\u6270\u7761\u7720\u5e76\u5f15\u53d1\u7236\u6bcd\u7126\u8651\u3002\u56e0\u6b64<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b57-dic-2025-7-7\"><\/a>\uff0c\u7236\u6bcd\u7ecf\u5e38\u5bfb\u6c42\u975e\u5904\u65b9\u836f\u6765\u7f13\u89e3\u5b69\u5b50\u7684\u54b3\u55fd\u3002<\/mark><\/p>\n<p class=\"wp-block-paragraph\">\u513f\u79d1\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u4e00\u4e2a\u5173\u952e\u7279\u5f81\u662f\u6c14\u9053\u9ecf\u6db2\u5206\u6ccc\u8fc7\u591a\uff0c\u5e38\u89c1\u4e8e\u56ca\u6027\u7ea4\u7ef4\u5316\u3001\u7ec6\u652f\u6c14\u7ba1\u708e\u3001\u80ba\u708e\u4ee5\u53ca\u6025\u6027\u548c\u6162\u6027\u652f\u6c14\u7ba1\u708e\u7b49\u75be\u75c5\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b58-dic-2025-7-7\">58<\/a>&nbsp;\u5c3d\u7ba1\u513f\u7ae5\u9ecf\u6db2\u75c5\u7406\u751f\u7406\u5b66\u7814\u7a76\u4e0d\u53ca\u6210\u4eba\uff0c\u4f46\u73b0\u6709\u8bc1\u636e\u8868\u660e\u5176\u673a\u5236\u7c7b\u4f3c\uff0c\u5305\u62ec\u676f\u72b6\u7ec6\u80de\u589e\u751f\u3001\u9ecf\u819c\u4e0b\u817a\u80a5\u5927\u548c\u6c14\u9053\u7c98\u6db2\u5835\u585e\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b58-dic-2025-7-7\">58<\/a>&nbsp;\u8fc7\u591a\u7684\u7c98\u6db2\u79ef\u7d2f\u4f1a\u52a0\u91cd\u54b3\u55fd\uff0c\u5f71\u54cd\u547c\u5438\uff0c\u4e25\u91cd\u65f6\u751a\u81f3\u963b\u585e\u6c14\u9053\u3002\u9274\u4e8e\u8fd9\u4e9b\u5e76\u53d1\u75c7\uff0c\u9ecf\u6db2\u6eb6\u89e3\u5242\u5728\u6cbb\u7597\u513f\u7ae5\u547c\u5438\u9053\u611f\u67d3\u76f8\u5173\u54b3\u55fd\u65b9\u9762\u5177\u6709\u663e\u8457\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u8fd9\u4e9b\u836f\u7269\u6709\u6548\u964d\u4f4e\u7c98\u7a20\u5ea6\u800c\u4e0d\u589e\u52a0\u5176\u4f53\u79ef\uff0c\u4fc3\u8fdb\u6c14\u9053\u901a\u7545\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b59-dic-2025-7-7\">59<\/a>&nbsp;\u6b64\u5916\uff0cNAC\u5177\u6709\u6297\u6c27\u5316\u3001\u6297\u611f\u67d3\u548c\u6297\u708e\u7279\u6027\uff0c\u53ef\u80fd\u52a0\u901f\u5eb7\u590d\uff0c\u800c\u5176\u7834\u574f\u751f\u7269\u819c\u548c\u6291\u5236\u7ec6\u83cc\u7c98\u9644\u7684\u80fd\u529b\u5219\u53ef\u80fd\u964d\u4f4e\u7ee7\u53d1\u611f\u67d3\u7684\u98ce\u9669\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b40-dic-2025-7-7\"><\/a>&nbsp;<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b10-dic-2025-7-7\">10,40<\/a><\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>NAC\u5728\u513f\u7ae5\u4e2d\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027<\/h2>\n<h3 class=\"wp-block-heading\">\u7eb3\u5165\u7814\u7a76<\/h3>\n<p class=\"wp-block-paragraph\">\u5173\u4e8eNAC\u5728\u513f\u7ae5\u4e2d\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u7814\u7a76\uff0c\u4e0e\u8bb8\u591a\u5173\u4e8e\u9ecf\u6db2\u6d3b\u6027\u5242\u7684\u7814\u7a76\u4e00\u6837\uff0c\u5927\u90e8\u5206\u662f\u57281997\u5e74\u300a\u826f\u597d\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b60-dic-2025-7-7\">\u300b\u7b2c60<\/a>\u53f7\u5b9e\u65bd\u4e4b\u524d\u8fdb\u884c\u7684\u3002\u8fd9\u4e9b\u6307\u5357\u5f15\u5165\u4e86\u56fd\u9645\u516c\u8ba4\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4f26\u7406\u548c\u79d1\u5b66\u6807\u51c6\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u672c\u7efc\u8ff0\u7eb3\u5165\u7684\u7814\u7a76\u603b\u4f53\u9075\u5faa\u6210\u719f\u7684\u65b9\u6cd5\u8bba\uff0c\u8fd9\u4e00\u70b9\u4ece\u7814\u7a76\u7ec8\u70b9\u7684\u4e00\u81f4\u6027\u4e2d\u53ef\u89c1\u4e00\u6591\uff0c\u652f\u6301\u5176\u6574\u4f53\u7a33\u5065\u6027\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u672c\u7efc\u8ff0\u6c47\u603b\u4e8620\u9879\u5bf9\u7167\u548c8\u9879\u975e\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u6db5\u76d6\u4e86\u51711438\u540d\u513f\u79d1\u60a3\u8005\uff0c\u4ee5\u53ca\u56de\u987e\u6027\u7814\u7a76\u7684\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\uff0c\u989d\u5916\u6d89\u53ca143\u540d\u513f\u79d1\u60a3\u8005\u3002\u8fd9\u4e9b\u7814\u7a76\u8bc4\u4f30\u4e86NAC\u5728\u591a\u79cd\u6025\u6027\u548c\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u5e94\u7528\u3002\u5177\u4f53\u6765\u8bf4\uff0c20\u9879\u4e34\u5e8a\u8bd5\u9a8c\u63a2\u8ba8\u4e86\u53e3\u670dNAC\uff0c3\u9879\u7814\u7a76\u4e86\u808c\u8089\u6ce8\u5c04\uff0c5\u9879\u8bc4\u4f30\u4e86\u96fe\u5316NAC\u3002\u5728\u771f\u5b9e\u7814\u7a76\u4e2d\uff0c\u4e24\u9879\u8bc4\u4f30\u4e86\u96fe\u5316NAC\uff0c\u4e00\u9879\u7814\u7a76\u4e86\u542b\u6709NAC\u7684\u652f\u6c14\u7ba1\u80ba\u6ce1\u704c\u6d17\uff08BAL\uff09\u3002\u6bcf\u9879\u7814\u7a76\u7684\u8be6\u7ec6\u4fe1\u606f\u89c1<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u88681<\/a>\u2013<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t3-dic-2025-7-7\">3<\/a>\u3002<\/p>\n<h4 class=\"wp-block-heading\">\u88681\u3002<\/h4>\n<p class=\"wp-block-paragraph\">\u5173\u4e8e\u513f\u79d1\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u4e2dNAC\u7684\u53d7\u63a7\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<figure class=\"wp-block-table\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>\u5b66\u4e60<\/th>\n<th>\u8bbe\u8ba1\/\u63a7\u5236\u7c7b\u578b<\/th>\n<th>\u7814\u7a76\u4e0e\u63a7\u5236\u836f\u7269<\/th>\n<th>\u6cbb\u7597\u6301\u7eed\u65f6\u95f4<\/th>\n<th>\u6309\u624b\u81c2\u548c\u5e74\u9f84\u5212\u5206\u7684\u53c2\u4e0e\u8005\u4eba\u6570<\/th>\n<th>\u8bca\u65ad<\/th>\n<th>\u7597\u6548\u7ed3\u679c<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"7\"><strong>\u6025\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Fiocchi \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">\u4eba\uff0c61<\/a><\/td>\n<td>\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/td>\n<td>\u53e3\u670dNAC 20 mg\/kg\/\u5929<em>\u4e0e\u5b89\u6170\u5242<\/em><\/td>\n<td>28\u5929<\/td>\n<td>100\u540d\u513f\u7ae5;\u5e73\u5747\u5e74\u9f84 7\u5c81<\/td>\n<td>\u652f\u6c14\u7ba1\u708e\uff0c\u6c14\u7ba1\u708e<\/td>\n<td>NAC\u663e\u8457\u51cf\u8f7b\u54b3\u55fd\u4e25\u91cd\u7a0b\u5ea6\uff0c\u6539\u5584\u80ba\u529f\u80fd\u548c\u80f8\u8154\u6e7f\u58f0<\/td>\n<\/tr>\n<tr>\n<td>Biscatti \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b21-dic-2025-7-7\">\u4eba\uff0c\u7b2c21<\/a>\u9875<\/td>\n<td>\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/td>\n<td>\u53e3\u670dNAC100\u6beb\u514b\/\u5929\uff08&lt;2\u5e74\uff09\u3001200\u6beb\u514b\/\u5929\uff082\u20134\u5e74\uff09\u3001300\u6beb\u514b\/\u5929\uff08&gt;4\u5e74\uff09<em>\u4e0e<\/em>\u5355\u7528\u6297\u751f\u7d20<\/td>\n<td>6\u5929<\/td>\n<td>50\u540d1\u81f312\u5c81\u513f\u7ae5<\/td>\n<td>\u80ba\u708e\u3001\u652f\u6c14\u7ba1\u708e\u3001\u6c14\u7ba1\u708e<\/td>\n<td>NAC\u6cbb\u7597\u4f7f\u53d1\u70e7\u548c\u80f8\u5ed3\u5f02\u5e38\u7684\u7f13\u89e3\u66f4\u5feb<\/td>\n<\/tr>\n<tr>\n<td>Hashemian \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b63-dic-2025-7-7\">\u4eba 63<\/a><\/td>\n<td>\u968f\u673a\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/td>\n<td>\u53e3\u670dNAC 1200 mg\/\u5929<em>\u4e0e<\/em>\u5b89\u6170\u5242<\/td>\n<td>7\u5929<\/td>\n<td>52\u540d8\u81f318\u5c81\u7684\u513f\u7ae5<\/td>\n<td>\u4e2d\u5ea6\u65b0\u51a0\u80ba\u708e<\/td>\n<td>NAC\u663e\u8457\u6539\u5584\u4e86\u8840\u6c27\u9971\u548c\u5ea6\uff0c\u7f29\u77ed\u4e86\u4f4f\u9662\u65f6\u95f4<\/td>\n<\/tr>\n<tr>\n<td>Trastotenojo \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b64-dic-2025-7-7\">\u4eba<\/a><\/td>\n<td>\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\u3002<br \/>\u5173\u4e8e\u968f\u673a\u5316\u7684\u7ec6\u8282\u4e0d\u53ef\u8003<\/td>\n<td>NAC 100\u6beb\u514b\u53e3\u670dTID<em>\u4e0e<\/em>\u5b89\u6170\u5242<\/td>\n<td>5\u5929<\/td>\n<td>60\u540d\u5e74\u9f84\u57282\u4e2a\u6708\u523013\u5c81\u7684\u513f\u7ae5<\/td>\n<td>\u652f\u6c14\u7ba1\u80ba\u708e\u3001\u54ee\u5598\u3001\u7ec6\u652f\u6c14\u7ba1\u708e\u3001\u7ed3\u6838\u75c5<\/td>\n<td>NAC\u968f\u7740\u65f6\u95f4\u63a8\u79fb\u6539\u5584\u4e86\u54b3\u55fd\u548c\u547c\u5438\u56f0\u96be<\/td>\n<\/tr>\n<tr>\n<td>Bellomo \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b65-dic-2025-7-7\">\u4eba\uff0c65<\/a><\/td>\n<td>\u968f\u673a\u3001\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76<\/td>\n<td>NAC\uff08\u53e3\u670d\u6216\u808c\u8089\u6ce8\u5c04\uff09\u6bcf\u5929300\u6beb\u514b\uff08&lt;2\u5e74\uff09\uff0c600\u6beb\u514b\/\u5929\uff08&gt;2\u5e74\uff09\u4e0e\u6807\u51c6\u6cbb\u7597<em>\u76f8\u6bd4<\/em><\/td>\n<td>8\u5929<\/td>\n<td>50\u540d6\u4e2a\u6708\u81f3&gt;2\u5c81\u7684\u513f\u7ae5<\/td>\n<td>\u6025\u6027\u652f\u6c14\u7ba1\u708e\uff0c\u80ba\u708e<\/td>\n<td>NAC\u6539\u5584\u4e86\u53d1\u70e7\u3001\u547c\u5438\u56f0\u96be\u3001\u80f8\u8154\u542c\u8bca\u548c\u54b3\u55fd\u3002\u53e3\u670d\u548c\u808c\u8089\u6ce8\u5c04\u7684NAC\u7597\u6548\u76f8\u5f53<\/td>\n<\/tr>\n<tr>\n<td>Camurri \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b66-dic-2025-7-7\">\u4eba 66<\/a><\/td>\n<td>\u968f\u673a\u3001\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76<\/td>\n<td>NAC 300 mg\/\u5929\uff08\u53e3\u670d\uff09<em>\u5bf9<\/em>&nbsp;\u6eb4\u5df1\u5b9a 48 mg\/\u5929\uff08\u53e3\u670d\uff09<\/td>\n<td>10\u5929<\/td>\n<td>32\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u57282\u81f311\u5c81\u4e4b\u95f4<\/td>\n<td>\u6025\u6027\u652f\u6c14\u7ba1\u708e<\/td>\n<td>\u8fd9\u4e24\u79cd\u6cbb\u7597\u90fd\u6539\u5584\u4e86\u75c7\u72b6;\u6eb4\u5df1\u5b9a\u7684\u7597\u6548\u66f4\u597d<\/td>\n<\/tr>\n<tr>\n<td>Chen \u7b49\u4eba\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b67-dic-2025-7-7\">67<\/a><\/td>\n<td>\u968f\u673a\u3001\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76<\/td>\n<td>NAC 300 mg BID \u6216 TID\uff0810% \u6eb6\u6db2\uff0c\u96fe\u5316\uff09+ \u5e03\u5730\u5948\u5fb7 0.25\u20130.5 mg BID\uff08\u96fe\u5316\uff09<em>\u4e0e<\/em>\u5355\u7528\u5e03\u5730\u5948\u5fb7<\/td>\n<td>14\u5929<\/td>\n<td>120\u540d\u513f\u7ae5\uff0c\u5e73\u5747\u5e74\u9f847.3\u5c81<\/td>\n<td>\u80ba\u708e<em>\u652f\u539f\u4f53<\/em>\u80ba\u708e<\/td>\n<td>NAC\u80fd\u66f4\u5feb\u7f13\u89e3\u54b3\u55fd\u3001\u53d1\u70e7\u548c\u6e83\u75a1\uff0c\u5e76\u964d\u4f4e\u708e\u75c7\u6807\u5fd7\u7269<\/td>\n<\/tr>\n<tr>\n<td>\u859b\u7b49\u4eba\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b68-dic-2025-7-7\">68<\/a>\u9875<\/td>\n<td>\u968f\u673a\u3001\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76<\/td>\n<td>NAC 300 mg BID\uff0810% \u6eb6\u6db2\uff0c\u96fe\u5316\uff09<em>\u4e0e<\/em>\u5b89\u5e03\u7f57\u7d22 300 mg BID\uff08\u96fe\u5316\uff09<\/td>\n<td>7\u5929<\/td>\n<td>98\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u57282\u81f36\u5c81\u4e4b\u95f4<\/td>\n<td>\u80ba\u708e<\/td>\n<td>NAC\u52a0\u5feb\u4e86\u53d1\u70e7\u3001\u54b3\u55fd\u548c\u80ba\u90e8\u6e83\u75a1\u7684\u7f13\u89e3\uff0c\u5e76\u6539\u5584\u4e86\u80ba\u529f\u80fd\u548c\u708e\u75c7\u6807\u5fd7\u7269<\/td>\n<\/tr>\n<tr>\n<td>Seidita \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b69-dic-2025-7-7\">\u4eba<\/a><\/td>\n<td>\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76<\/td>\n<td>NAC 300 mg\/\u5929\uff08\u53e3\u670d\uff09<em>\u4e0e<\/em>\u7d22\u5e03\u7f57\u5c14 100 mg TID\uff08\u53e3\u670d\uff09<\/td>\n<td>3\u5929<\/td>\n<td>40\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u57283\u81f312\u5c81\u4e4b\u95f4<\/td>\n<td>\u652f\u6c14\u7ba1\u708e\uff0c\u54bd\u6c14\u7ba1\u652f\u6c14\u7ba1\u708e<\/td>\n<td>\u4e24\u79cd\u6cbb\u7597\u90fd\u6709\u6548\uff0c\u7d22\u5e03\u7f57\u5c14\u7684\u75f0\u6db2\u7c98\u5ea6\u964d\u4f4e\u7565\u597d<\/td>\n<\/tr>\n<tr>\n<td>\u5218\u7b49\u4eba\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b71-dic-2025-7-7\">71<\/a><\/td>\n<td>\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76<\/td>\n<td>NAC 300\u6beb\u514b\u6bcf\u65e5\u4e24\u6b21\uff0810%\u6eb6\u6db2\uff0c\u96fe\u5316\uff09<em>\u4e0e<\/em>\u5b89\u5e03\u7f57\u7d2230\u6beb\u514b\u6bcf\u65e5\u4e24\u6b21\uff08\u96fe\u5316\uff09<\/td>\n<td>14\u5929<\/td>\n<td>120\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u4e3a1\u81f37\u5c81<\/td>\n<td>\u652f\u6c14\u7ba1\u80ba\u708e<\/td>\n<td>NAC\u5728\u51cf\u8f7b\u75c7\u72b6\u548c\u63d0\u5347\u514d\u75ab\u529f\u80fd\u65b9\u9762\u66f4\u6709\u6548<\/td>\n<\/tr>\n<tr>\n<td colspan=\"7\"><strong>\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5<\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u7c73\u5207\u5c14\u4e0e\u57c3\u5229\u5965\u7279<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b72-dic-2025-7-7\">72<\/a><\/td>\n<td>\u968f\u673a\u3001\u4ea4\u53c9\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/td>\n<td>NAC 200\u6beb\u514b\u53e3\u670dTID<em>\u4e0e<\/em>\u5b89\u6170\u5242<\/td>\n<td>\u4e24\u4e2a\u4e09\u4e2a\u6708\u7684\u5468\u671f<\/td>\n<td>20\u540d\u513f\u7ae5\uff0c\u5e73\u5747\u5e74\u9f8410.8\u5c81<\/td>\n<td>CF<\/td>\n<td>\u80ba\u529f\u80fd<em>\u4e0e<\/em>\u5b89\u6170\u5242\u65e0\u663e\u8457\u5dee\u5f02<\/td>\n<\/tr>\n<tr>\n<td>Stafanger \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b73-dic-2025-7-7\">\u4eba\uff0c73<\/a><\/td>\n<td>\u968f\u673a\u3001\u4ea4\u53c9\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/td>\n<td>\u53e3\u670dNAC 200\u6beb\u514bTID\uff08&lt;30\u516c\u65a4\uff09\u6216\u53e3\u670d400\u6beb\u514b\u53cc\u5242\u91cf\uff08&gt;30\u516c\u65a4\uff09<em>\u4e0e<\/em>\u5b89\u6170\u5242<\/td>\n<td>\u4e24\u4e2a\u4e09\u4e2a\u6708\u7684\u5468\u671f<\/td>\n<td>54\u540d\u5b50\u5973;\u5e73\u5747\u5e74\u9f849.5\u5c81\uff08CF\uff09\uff0c29.7\u5c81\uff08PCD\uff09<\/td>\n<td>FC\uff08<em>n<\/em>=41\uff09\uff0cLGD\uff08<em>n<\/em>=13\uff09<\/td>\n<td>NAC\u5728\u611f\u67d3\u9ad8\u5cf0\u671f\u6539\u5584\u4e86CF\u60a3\u8005\u7684\u80ba\u529f\u80fd\u3002PCD\u60a3\u8005<br \/>\u672a\u89c2\u5bdf\u5230\u663e\u8457\u6548\u679c<\/td>\n<\/tr>\n<tr>\n<td>Stafanger \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">\u4eba 74<\/a><\/td>\n<td>\u968f\u673a\u3001\u4ea4\u53c9\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/td>\n<td>\u53e3\u670dNAC 200\u6beb\u514bTID\uff08&lt;30\u516c\u65a4\uff09\u6216\u53e3\u670d400\u6beb\u514b\u53cc\u5242\u91cf\uff08&gt;30\u516c\u65a4\uff09<em>\u4e0e<\/em>\u5b89\u6170\u5242<\/td>\n<td>3\u4e2a\u6708<\/td>\n<td>52\u540d\u513f\u7ae5\uff0c\u5e73\u5747\u5e74\u9f8415.8\u5c81<\/td>\n<td>\u6162\u6027\u94dc\u7eff<em>\u5047\u5355\u80de<\/em>\u83cc\u611f\u67d3\u56ca\u6027\u7ea4\u7ef4\u5316<\/td>\n<td>NAC\u5728\u91cd\u75c7\u56ca\u6027\u7ea4\u7ef4\u5316\u60a3\u8005\u4e2d\u663e\u8457\u6539\u5584\u80ba\u529f\u80fd\uff08PEFR&lt;70%\uff09<\/td>\n<\/tr>\n<tr>\n<td>Ratjen \u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b75-dic-2025-7-7\">75<\/a>\u9875<\/td>\n<td>\u968f\u673a\u3001\u5e73\u884c\u7ec4\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/td>\n<td>NAC 200\u6beb\u514bTID<em>\u4e0e<\/em>\u5b89\u5e03\u6d1b\u7d2230\u6beb\u514bTID<em>\u5bf9\u6bd4<\/em>\u5b89\u6170\u5242<\/td>\n<td>3\u4e2a\u6708<\/td>\n<td>36\u540d\u513f\u7ae5\uff0c\u5e73\u5747\u5e74\u9f8413.9\u5c81<\/td>\n<td>CF<\/td>\n<td>\u80ba\u529f\u80fd\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u4f46\u5b89\u6170\u5242\u7ec4\u663e\u793a\u51fa\u660e\u663e\u4e0b\u964d\u8d8b\u52bf<\/td>\n<\/tr>\n<tr>\n<td>Gotz \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b76-dic-2025-7-7\">\u4eba 76<\/a><\/td>\n<td>\u968f\u673a\u3001\u4ea4\u53c9\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/td>\n<td>\u53e3\u670dNAC 9.5 mg\/kg<em>\u4e0e\u5b89\u6170\u5242<\/em><\/td>\n<td>14\u5929<\/td>\n<td>21\u4e2a\u5b69\u5b50<\/td>\n<td>CF<\/td>\n<td>\u8fd9\u4e24\u79cd\u6cbb\u7597\u90fd\u5e26\u6765\u4e86\u5168\u7403\u6027\u7684\u6539\u5584\uff0c\u4e14\u4e24\u8005\u4e4b\u95f4\u6ca1\u6709\u660e\u663e\u5dee\u5f02<\/td>\n<\/tr>\n<tr>\n<td>Baran\u7b49\u4eba\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b77-dic-2025-7-7\">77<\/a>\u9875<\/td>\n<td>\u968f\u673a\u3001\u4ea4\u53c9\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/td>\n<td>\u53e3\u670dNAC 19.4 mg\/kg<em>\u4e0e\u5b89\u6170\u5242<\/em><\/td>\n<td>15\u5929<\/td>\n<td>6\u4e2a\u5b69\u5b50<\/td>\n<td>CF<\/td>\n<td>NAC\u6539\u5584\u4e86FEV<sub>1<\/sub>\u3001PEFR\u548c\u6700\u5927\u547c\u6c14\u6d41\u91cf<\/td>\n<\/tr>\n<tr>\n<td>Rudnik \u7b49\u4eba&nbsp;<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b78-dic-2025-7-7\">78<\/a><\/td>\n<td>\u5f00\u653e\u6807\u7b7e\u3001\u5bf9\u7167\u7814\u7a76<\/td>\n<td>NAC 50\u6beb\u514b\u6bcf\u65e5\u95f4\u6ce8\u5c04\u6216200\u6beb\u514b\u95f4\u6b47\u6027\u6ce8\u5c04\uff08\u53e3\u670d\uff09<\/td>\n<td>4\u5468<\/td>\n<td>58\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u4ece2\u4e2a\u6708\u523016\u5c81<\/td>\n<td>\u6162\u6027\u80ba\u75c5<\/td>\n<td>NAC\u4f7f89%\u7684\u60a3\u8005\u4e34\u5e8a\u6539\u5584\uff0c\u5176\u4e2d\u4e00\u90e8\u5206\u60a3\u8005\u80ba\u529f\u80fd\u7565\u6709\u6539\u5584<\/td>\n<\/tr>\n<tr>\n<td>Steil \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b79-dic-2025-7-7\">\u4eba\uff0c79<\/a>\u9875<\/td>\n<td>\u5f00\u653e\u6807\u7b7e\u4ea4\u53c9\u7814\u7a76<\/td>\n<td>\u53e3\u670dNAC 10\u201330 mg\/kg\/\u5929\uff0c<em>\u5bf9\u6297<\/em>\u78b3\u534a\u80f1\u6c28\u9178<\/td>\n<td>3\u20136\u4e2a\u6708<\/td>\n<td>22\u4e2a\u5b69\u5b50<\/td>\n<td>CF<\/td>\n<td>NAC\u5728\u57fa\u7ebfFVC\u513f\u7ae5\u4e2d\u6539\u5584\u80ba\u529f\u80fd&lt;75%<\/td>\n<\/tr>\n<tr>\n<td>Baldini \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b80-dic-2025-7-7\">\u4eba\uff0c80<\/a><\/td>\n<td>\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76<\/td>\n<td>\u53e3\u670dNAC 200\u2013300 mg\/\u5929&nbsp;<em>vs<\/em>&nbsp;\u5b89\u5e03\u7f57\u7d2230 mg\/\u5929<\/td>\n<td>10\u5929<\/td>\n<td>28\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u57282\u81f313\u5c81\u4e4b\u95f4<\/td>\n<td>\u75c9\u631b\u6027\u652f\u6c14\u7ba1\u708e<\/td>\n<td>\u4e24\u79cd\u6cbb\u7597\u90fd\u5f88\u6709\u6548\uff0c\u5b89\u5e03\u6d1b\u7d22\u7684\u75c7\u72b6\u7f13\u89e3\u66f4\u5feb<\/td>\n<\/tr>\n<tr>\n<td>Dietzsch \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b81-dic-2025-7-7\">\u4eba\uff0c81<\/a>\u9875<\/td>\n<td>\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76<\/td>\n<td>NAC 10%\uff08\u96fe\u5316\uff09\uff0c\u968f\u540e\u662fL-\u7cbe\u6c28\u9178\u76d0\u9178\u76d05%\uff08\u96fe\u5316\uff09<\/td>\n<td>NAC\u6cbb\u7597\u524d\u6301\u7eed\u65f6\u95f4\u4e0d\u8be6\uff0c4\u81f310\u5468\uff08L-\u7cbe\u6c28\u9178\u76d0\u9178\u76d0\uff09<\/td>\n<td>24\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u57282\u81f312\u5c81\u4e4b\u95f4<\/td>\n<td>CF<\/td>\n<td>NAC\u663e\u793a\u51fa\u66f4\u4f18\u8d8a\u7684\u9ecf\u6db2\u6eb6\u89e3\u6548\u679c\u3002L-\u7cbe\u6c28\u9178\u76d0\u9178\u76d0\u4e0d\u5e94\u7528\u4e8e\u6cbb\u7597\u513f\u7ae5\u56ca\u6027\u7ea4\u7ef4\u5316<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p class=\"wp-block-paragraph\">\u663e\u793a\u8be6\u7ec6\u4fe1\u606f<\/p>\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12657002\/table\/t1-dic-2025-7-7\/\">\u5728\u65b0\u6807\u7b7e\u9875\u4e2d\u6253\u5f00<\/a><\/p>\n<p class=\"wp-block-paragraph\"><em>BID\uff0cbis in die<\/em>;\u56ca\u6027\u7ea4\u7ef4\u5316\uff08CF\uff09;FEV<sub>1,1<\/sub>\u79d2\u5185\u7684\u5f3a\u5236\u547c\u6c14\u91cf;FVC\uff0c\u5f3a\u5236\u80ba\u6d3b\u91cf;\u808c\u8089\u5185\u79d1\uff0c\u808c\u8089\u6ce8\u5c04;NAC\uff0cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178;PCD\uff0c\u539f\u53d1\u6027\u776b\u72b6\u4f53\u8fd0\u52a8\u969c\u788d;PEFR\uff0c\u5cf0\u503c\u547c\u6c14\u6d41\u91cf;TID\uff0c<em>\u7279\u5c14\u00b7\u56e0\u00b7\u8fea\u3002<\/em><\/p>\n<h4 class=\"wp-block-heading\">\u88682\u3002<\/h4>\n<p class=\"wp-block-paragraph\">\u5173\u4e8e\u513f\u79d1\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u4e2dNAC\u7684\u975e\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<figure class=\"wp-block-table\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>\u5b66\u4e60<\/th>\n<th>\u7814\u7a76\u548c\u63a7\u5236\u836f\u7269\uff08\u5242\u91cf\u3001\u9014\u5f84\u3001\u65b9\u6848\uff09<\/th>\n<th>\u6cbb\u7597\u6301\u7eed\u65f6\u95f4<\/th>\n<th>\u6309\u624b\u81c2\u548c\u5e74\u9f84\u5212\u5206\u7684\u53c2\u4e0e\u8005\u4eba\u6570<\/th>\n<th>\u8bca\u65ad<\/th>\n<th>\u7597\u6548\u7ed3\u679c<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"6\"><strong>\u6025\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Bellomo \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b18-dic-2025-7-7\">\u4eba<\/a><\/td>\n<td>\u808c\u8089\u6ce8\u5c04\u7ec4\u5408\uff0cNAC 10\u201318 mg\/kg\/\u5929 + \u786b\u82ef\u5c3c\u9187\u7518\u6c28\u9178\u76d0 22\u201340 mg\/kg\/\u5929<\/td>\n<td>4\u201318\u5929<\/td>\n<td>39\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u4ece2\u4e2a\u6708\u523011\u5c81<\/td>\n<td>\u652f\u6c14\u7ba1\u80ba\u611f\u67d3<\/td>\n<td>NAC\u548c\u786b\u82ef\u4e8c\u915a\u7518\u6c28\u9178\u7684\u8054\u5408\u4f7f\u7528\u4f7f\u53d1\u70e7\u3001\u547c\u5438\u56f0\u96be\u3001\u54b3\u55fd\u8fc5\u901f\u7f13\u89e3\uff0c\u5e76\u6539\u5584\u4e86\u80f8\u90e8X\u5149\u68c0\u67e5\u7ed3\u679c<\/td>\n<\/tr>\n<tr>\n<td>Santangelo \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b19-dic-2025-7-7\">\u4eba 19<\/a><\/td>\n<td>NAC 20\u201330 mg\/kg\/\u5929\uff08\u6ce8\u5c04\u4e2d\uff09+ \u5934\u5b62\u544b\u8f9b<\/td>\n<td>5\u201310\u5929<\/td>\n<td>103\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u4ece2\u4e2a\u6708\u523011\u5c81<\/td>\n<td>\u4e0b\u547c\u5438\u9053\u611f\u67d3<\/td>\n<td>NAC\u4f7f97%\u7684\u513f\u7ae5\u663e\u8457\u6539\u5584\uff0c\u5fae\u751f\u7269\u5b66\u4e0a\u6e05\u9664\u4e86\u81f4\u75c5\u83cc\u682a<\/td>\n<\/tr>\n<tr>\n<td colspan=\"6\"><strong>\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Ribeiro \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b82-dic-2025-7-7\">\u4eba 82<\/a><\/td>\n<td>\u53e3\u670dNAC 10\u201350 mg\/kg\/\u5929<\/td>\n<td>7\u2013110\u5929<\/td>\n<td>80\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u4ece23\u5929\u523011\u5c81<\/td>\n<td>\u6162\u6027\u80ba\u90e8\u75be\u75c5<\/td>\n<td>NAC\u4f7f88%\u7684\u513f\u7ae5\u4e34\u5e8a\u6539\u5584\uff0c82%\u7684\u75c5\u4f8b\u653e\u5c04\u5b66\u7f13\u89e3<\/td>\n<\/tr>\n<tr>\n<td>Szekely \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b83-dic-2025-7-7\">\u4eba 83<\/a><\/td>\n<td>\u53e3\u670dNAC 100\u6beb\u514b TID\uff08\u53e3\u670d\uff09<\/td>\n<td>37\u5929<\/td>\n<td>20\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u57286\u81f312\u5c81\u4e4b\u95f4<\/td>\n<td>\u6162\u6027\u652f\u6c14\u7ba1\u708e<\/td>\n<td>NAC\u4f7f50%\u60a3\u8005\u7684\u9ecf\u819c\u708e\u75c7\u51cf\u5c11\uff0c\u6240\u6709\u60a3\u8005\u7684\u9ecf\u6db2\u8fc7\u5ea6\u5206\u6ccc\u51cf\u5c11\u6216\u505c\u6b62<\/td>\n<\/tr>\n<tr>\n<td>Nikolic \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b84-dic-2025-7-7\">\u4eba 84<\/a>\u9875<\/td>\n<td>\u53e3\u670dNAC 100\u2013200\u6beb\u514bTID+\u6297\u751f\u7d20<\/td>\n<td>4\u5929<\/td>\n<td>20\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u57283\u81f314\u5c81\u4e4b\u95f4<\/td>\n<td>\u53cd\u590d\u53d1\u70ed\u6027\u652f\u6c14\u7ba1\u708e<\/td>\n<td>NAC\u7f29\u77ed\u4e86\u975e\u8fc7\u654f\u513f\u7ae5\u7684\u75c7\u72b6\u6301\u7eed\u65f6\u95f4\u5e76\u6539\u5584\u4e86\u80ba\u529f\u80fd<\/td>\n<\/tr>\n<tr>\n<td>Dietzsch \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b85-dic-2025-7-7\">\u4eba\uff0c85<\/a>\u9875<\/td>\n<td>NAC 100\u6beb\u514bTID\uff08&lt;8\u5e74\uff09\u6216200\u6beb\u514bTID\uff08\u22658\u5e74\uff09\uff08\u53e3\u670d\uff09<\/td>\n<td>6\u4e2a\u6708<\/td>\n<td>42\u540d\u513f\u7ae5\u5728\u63a5\u53d7NAC\u5438\u5165\u6cbb\u7597\u671f\u95f4\u7a33\u5b9a8\u81f310\u5e74<\/td>\n<td>CF<\/td>\n<td>\u4ece\u5438\u5165\u6cbb\u7597\u8f6c\u4e3a\u53e3\u670d\u6cbb\u7597\u7684NAC\u4f7f56%\uff08\u652f\u6c14\u7ba1\u955c\uff09\u548c69%\uff08\u80ba\u529f\u80fd\u6d4b\u8bd5\uff09\u60a3\u8005\u80ba\u529f\u80fd\u7a33\u5b9a\u6216\u6539\u5584<\/td>\n<\/tr>\n<tr>\n<td>Stephan \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b86-dic-2025-7-7\">\u4eba\uff0c86<\/a>\u9875<\/td>\n<td>\u53e3\u670dNAC 50\u6beb\u514bTID\uff08&lt;2\u5e74\uff09\u6216200\u6beb\u514bTID\uff08&gt;2\u5e74\uff09\uff08\u53e3\u670d\uff09<\/td>\n<td>2\u5e74<\/td>\n<td>63\u540d\u5e74\u9f84\u57282\u81f320\u5c81\u7684\u513f\u7ae5\uff0c\u63a5\u53d7\u4e86\u81f3\u5c11\u4e00\u5e74\u7684Mesna\u6216NAC\u5438\u5165\u7597\u6cd5<\/td>\n<td>CF<\/td>\n<td>NAC\u663e\u793a\u53e3\u670d\u4e0e\u5438\u5165\u7ed9\u836f\u5728\u6539\u5584\u75f0\u6db2\u6e05\u9664\u7387\u3001\u80f8\u90e8X\u5149\u8868\u73b0\u548c\u751f\u957f\u53c2\u6570\u65b9\u9762\u7684\u7597\u6548\u76f8\u5f53<\/td>\n<\/tr>\n<tr>\n<td>Reas \u7b49\u4eba\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b87-dic-2025-7-7\">\u7b2c87<\/a>\u9875<\/td>\n<td>NAC 5\u6beb\u534720%\u6eb6\u6db2\uff081\u514b\uff09\u53cc\u4e95\uff08\u96fe\u5316\uff09<\/td>\n<td>10\u5468\u523038\u4e2a\u6708<\/td>\n<td>28\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u57287\u81f322\u5c81\u4e4b\u95f4<\/td>\n<td>CF<\/td>\n<td>NAC\u6539\u5584\u80ba\u529f\u80fd\uff0c\u4fc3\u8fdb\u7ebf\u6027\u751f\u957f\u548c\u4f53\u91cd\u589e\u52a0\uff0c\u589e\u52a0\u8fd0\u52a8\u80fd\u529b\uff0c\u51cf\u5c11\u547c\u5438\u8d1f\u8377<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p class=\"wp-block-paragraph\">\u663e\u793a\u8be6\u7ec6\u4fe1\u606f<\/p>\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12657002\/table\/t2-dic-2025-7-7\/\">\u5728\u65b0\u6807\u7b7e\u9875\u4e2d\u6253\u5f00<\/a><\/p>\n<p class=\"wp-block-paragraph\">BID\uff0c<em>\u6700\u9ad8\u8fbe;<\/em>\u56ca\u6027\u7ea4\u7ef4\u5316\uff08CF\uff09;\u808c\u8089\u5185\u79d1\uff0c\u808c\u8089\u6ce8\u5c04;NAC\uff0cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178;TID\uff0c<em>\u7279\u5c14\u5728\u90a3\u4e2a<\/em>\u3002<\/p>\n<h4 class=\"wp-block-heading\">\u88683\u3002<\/h4>\n<p class=\"wp-block-paragraph\">\u5173\u4e8e\u513f\u79d1\u547c\u5438\u75be\u75c5\u4e2dNAC\u7684\u771f\u5b9e\u8bc1\u636e\u3002<\/p>\n<figure class=\"wp-block-table\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>\u5b66\u4e60<\/th>\n<th>\u8bbe\u8ba1\/\u63a7\u5236\u7c7b\u578b<\/th>\n<th>\u7814\u7a76\u548c\u63a7\u5236\u836f\u7269\uff08\u5242\u91cf\u3001\u9014\u5f84\u3001\u65b9\u6848\uff09<\/th>\n<th>\u6309\u624b\u81c2\u548c\u5e74\u9f84\u5212\u5206\u7684\u53c2\u4e0e\u8005\u4eba\u6570<\/th>\n<th>\u8bca\u65ad<\/th>\n<th>\u7597\u6548\u7ed3\u679c<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"6\"><strong>\u6025\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Zanasi \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b20-dic-2025-7-7\">\u4eba 20<\/a><\/td>\n<td>\u516c\u5f00\u56de\u987e\u6027\u7814\u7a76<\/td>\n<td>NAC\u6216\u96fe\u5316\u7d22\u5e03\u7f57\u5c14<em>\u4e0e\u6297\u751f\u7d20\u7684\u6bd4\u8f83<\/em><\/td>\n<td>59\u540d\u513f\u7ae5\uff0c\u5e74\u9f84\u57283\u81f314\u5c81\u4e4b\u95f4<\/td>\n<td>\u6025\u6027\u4e0a\u547c\u5438\u9053\u611f\u67d3\u4f34\u6709\u6e7f\u54b3<\/td>\n<td>\u9ecf\u6db2\u6eb6\u89e3\u5242\u5728\u6539\u5584\u54b3\u55fd\u4e25\u91cd\u5ea6\u548c\u75f0\u6db2\u6e05\u9664\u65b9\u9762\u6bd4\u6297\u751f\u7d20\u66f4\u6709\u6548<\/td>\n<\/tr>\n<tr>\n<td colspan=\"6\"><strong>\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Kumar \u7b49\u4eba&nbsp;<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b88-dic-2025-7-7\">88<\/a><\/td>\n<td>\u6848\u4f8b\u7cfb\u5217<\/td>\n<td>NAC 1.5\u20132.5\u6beb\u534720%\u6eb6\u6db2\uff08300\u2013500\u6beb\u514b\uff09\u53cc\u4e95\uff08\u96fe\u5316\uff09<\/td>\n<td>\u4e24\u4e2a\u5b69\u5b50\uff0c\u5206\u522b\u662f1\u5c81\u548c7\u5c81<\/td>\n<td>\u5851\u6599\u652f\u6c14\u7ba1\u708e<\/td>\n<td>NAC\u5e26\u6765\u4e86\u663e\u8457\u6539\u5584\uff0c\u60a3\u8005\u5728\u968f\u8bbf\u65f6\u4fdd\u6301\u65e0\u75c7\u72b6<\/td>\n<\/tr>\n<tr>\n<td>Wang \u7b49\u4eba\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b89-dic-2025-7-7\">89<\/a>\u9875<\/td>\n<td>\u56de\u987e\u6027\u961f\u5217\u7814\u7a76<\/td>\n<td>NAC + \u5e03\u5730\u5948\u5fb7&nbsp;<em>vs<\/em>&nbsp;\u5b89\u5e03\u7f57\u7d22 + \u5e03\u5730\u5948\u5fb7 vs \u5355\u7eaf\u5e03\u5730\u5948\u5fb7<em>\u52a0<\/em>\u7528\u4e8eBAL\u6db2\u4f53\u836f\u7269<\/td>\n<td>82\u540d\u5b50\u5973<\/td>\n<td>\u96be\u6cbb\u6027<em>\u80ba\u708e\u652f\u539f\u4f53<\/em>\u80ba\u708e<\/td>\n<td>BAL\u5076\u8054NAC+\u5e03\u5730\u5948\u5fb7\u663e\u8457\u964d\u4f4e\u8840\u6e05\u4e73\u9178\u8131\u6c22\u9176\u548c\u8840\u6e05\u94c1\u86cb\u767d\u6c34\u5e73\uff0c\u4e34\u5e8a\u7597\u6548\u66f4\u597d\uff0c\u80ba\u90e8\u5f71\u50cf\u5b66\u6539\u5584<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p class=\"wp-block-paragraph\">\u663e\u793a\u8be6\u7ec6\u4fe1\u606f<\/p>\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12657002\/table\/t3-dic-2025-7-7\/\">\u5728\u65b0\u6807\u7b7e\u9875\u4e2d\u6253\u5f00<\/a><\/p>\n<p class=\"wp-block-paragraph\">BAL\uff0c\u652f\u6c14\u7ba1\u80ba\u6ce1\u6d17\u6d17;BID\uff0c<em>\u6700\u9ad8\u8fbe;<\/em>NAC\uff0cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u3002<\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>NAC\u5728\u513f\u79d1\u6025\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u7597\u6548\u6982\u51b5<\/h2>\n<h3 class=\"wp-block-heading\">\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76<\/h3>\n<h4 class=\"wp-block-heading\">\u968f\u673a\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/h4>\n<p class=\"wp-block-paragraph\">Fiocchi\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff0c\u63a2\u8ba8NAC\u5728\u6cbb\u7597\u6025\u6027\u4e0b\u547c\u5438\u9053\u611f\u67d3\u60a3\u8005\uff08\u5305\u62ec\u652f\u6c14\u7ba1\u708e\u548c\u6c14\u7ba1\u708e\uff09\u4e2d\u7684\u7597\u6548\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u8be5\u7814\u7a76\u7eb3\u5165\u4e86100\u540d\u513f\u7ae5\uff08\u652f\u6c14\u7ba1\u708e\uff08<em>n<\/em>=48\uff09\u548c\u6c14\u7ba1\u708e\uff08<em>n<\/em>=52\uff09\uff09\uff0c\u5e73\u5747\u5206\u914d\u7ed9\u63a5\u53d7NAC\u7cd6\u6d46\uff0820 mg\/kg\/\u5929\uff0c\u5206\u4e09\u6b21\u5206\u91cf\uff09\u548c\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u768428\u5929\u5185\u513f\u7ae5\u3002NAC\u7ec4\u5e73\u5747\u5e74\u9f84\u4e3a7.3\u00b13.4\u5c81\uff0c\u5e73\u5747\u4f53\u91cd\u4e3a23.9\u00b111.3\u516c\u65a4\uff0c\u5b89\u6170\u5242\u7ec4\u5e73\u5747\u5e74\u9f84\u4e3a6.7\u00b13.0\u5c81\uff0c\u5e73\u5747\u4f53\u91cd\u4e3a25\u00b111.1\u516c\u65a4\u3002\u5fc5\u8981\u65f6\u5f00\u5177\u6297\u751f\u7d20\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u8be5\u7814\u7a76\u6839\u636e\u547c\u5438\u53c2\u6570\u3001\u54b3\u55fd\u4e25\u91cd\u7a0b\u5ea6\u548c\u751f\u4ea7\u529b\uff0c\u4ee5\u53ca\u5728\u53ef\u884c\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u80ba\u529f\u80fd\u6d4b\u8bd5\u8bc4\u4f30\uff0c\u8bc4\u4f30\u6cbb\u7597\u7ed3\u679c\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">61<\/a>&nbsp;\u7ed3\u679c\u663e\u793a\uff0cNAC\u5728\u7f13\u89e3\u75c7\u72b6\u548c\u6539\u5584\u547c\u5438\u7cfb\u7edf\u8868\u73b0\u65b9\u9762\u66f4\u6709\u6548\uff0c\u5c24\u5176\u662f\u5728\u652f\u6c14\u7ba1\u611f\u67d3\u8f83\u91cd\u7684\u513f\u7ae5\u4e2d\u3002\u4e9a\u7ec4\u5206\u6790\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u652f\u6c14\u7ba1\u708e\u513f\u7ae5\u4e2dNAC\u663e\u8457\u51cf\u5c11\u80f8\u8154\u6e7f\u58f0\uff0c\u6539\u5584\u54b3\u55fd\u75c7\u72b6\u548c\u54b3\u55fd\u6548\u7387\uff08<em>p<\/em>&lt;0.05\uff09\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#f1-dic-2025-7-7\">\u89c1\u56fe1A<\/a>\uff09\u3002NAC\u7ec4\u7684\u5e73\u5747\u54b3\u55fd\u8bc4\u5206\u4ece0\uff08\u7f3a\u5931\uff09\u52303\uff08\u663e\u8457\uff09\u4ece2.15\u964d\u81f30.08\uff08<em>p<\/em>&lt;0.001\uff09\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u5219\u4ece2.19\u964d\u81f30.48\uff08<em>p<\/em>&lt;0.001\uff09\u3002\u6c14\u7ba1\u708e\u75c5\u4f8b\u4e2d\uff0cNAC\u4f7f\u54b3\u55fd\u75c7\u72b6\u76f8\u8f83\u5b89\u6170\u5242\u663e\u8457\u6539\u5584\uff08\u54b3\u55fd\u4e25\u91cd\u5ea6\uff1a<em>p<\/em>&lt;0.05;\u54b3\u55fd\u7387\uff1a<em>p<\/em>=0.05\uff09\uff0c\u80f8\u90e8\u6e7f\u58f0\u8f83\u6cbb\u7597\u524d\u6c34\u5e73\u663e\u8457\u51cf\u5c11\uff08<em>p<\/em>&lt;0.01\uff09\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#f1-dic-2025-7-7\">\u89c1\u56fe1B<\/a>\uff09\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5b89\u6170\u5242\u7ec4\u5728\u6cbb\u7597\u671f\u95f4\u80f8\u90e8\u6e7f\u58f0\u7684\u51cf\u5c11\u65e0\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#f1-dic-2025-7-7\">\u89c1\u56fe1B<\/a>\uff09\u3002<\/p>\n<figure class=\"wp-block-image\" id=\"f1-dic-2025-7-7\"><a class=\"tileshop\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=12657002_DIC-2025-7-7-BENEDETTI-Figure1.jpg\" data-lightbox=\"image_lg\"><img title=\"NAC\u5728\u513f\u79d1\u4e2d\u7684\u5e94\u7528\uff1a\u547c\u5438\u62a4\u7406\u4e2d\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u5242\u91cf\u7b56\u7565\u7efc\u8ff0 - \u7b2c1\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"NAC\u5728\u513f\u79d1\u4e2d\u7684\u5e94\u7528\uff1a\u547c\u5438\u62a4\u7406\u4e2d\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u5242\u91cf\u7b56\u7565\u7efc\u8ff0 - \u7b2c1\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\"  data-perfmatters-preload width=\"774\" height=\"875\"  data-src=\"https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2025\/12\/DIC-2025-7-7-BENEDETTI-Figure1.jpg\" class=\"wp-image-9792 no-lazy\" \/><\/a><figcaption class=\"wp-element-caption\">N-\u4e59\u9170\u534a\u6c28\u9178\uff08NAC\uff09\u5728\u51cf\u8f7b\u652f\u6c14\u7ba1\u708e\uff08A\uff09\u548c\u6c14\u7ba1\u708e\uff08B\uff09\u513f\u7ae5\u547c\u5438\u75c7\u72b6\u65b9\u9762\u7684\u7597\u6548\u3002\u539f\u8bba\u6587<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">61<\/a>\u7684\u4f5c\u8005\u91c7\u7528\u914d\u5bf9<em>t<\/em>\u68c0\u9a8c\uff08*<em>p<\/em>&lt;0.05;**<em>p<\/em>&lt;0.01;***<em>p<\/em>&lt;0.001\uff09\u8fdb\u884c\u4e86\u7b2c28\u5929\u4e0e\u7b2c1\u5929\u7684\u6bd4\u8f83\u3002\u539f\u8bba\u6587<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">61<\/a>\u4e2d\uff0c\u4f5c\u8005\u901a\u8fc7\u72ec\u7acb<em>t<\/em>\u68c0\u9a8c\uff08\u00b0<em>p<\/em>&lt;0.05;<sup>#<\/sup><em>p<\/em>=0.05;^<em>p<\/em>=0.02\uff09\u3002<sup>\u00a7<\/sup>\u5b89\u6170\u5242\uff1a\u5355\u72ec\u4f7f\u7528\u6297\u751f\u7d20;<sup>\u00a7\u00a7<\/sup>NAC\uff1a\u6297\u751f\u7d20+NAC\u3002<\/figcaption><\/figure>\n<p class=\"wp-block-paragraph\">\u5728\u652f\u6c14\u7ba1\u708e\u60a3\u8005\u4e2d\uff0cNAC\u7ec4\u5728\u6cbb\u7597\u7b2c\u4e8c\u5468\u7ed3\u675f\u65f6\u80f8\u90e8\u6e7f\u58f0\u548c\u54b3\u55fd\u4ea7\u51fa\u7684\u79ef\u6781\u53d8\u5316\u9891\u7387\u663e\u8457\u66f4\u9ad8\uff08<em>p<\/em>&lt;0.05\uff09\u3002\u7136\u800c\uff0c\u8fd9\u4e00\u663e\u8457\u6027\u5728\u6cbb\u7597\u671f\u7ed3\u675f\u65f6\u6d88\u5931\uff0c\u8868\u660eNAC\u7684\u7597\u6548\u66f4\u65e9\u663e\u73b0\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u6c14\u7ba1\u708e\u60a3\u8005\u4ec5\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\u6709\u9633\u6027\u4fee\u6b63\u6570\u636e\uff0c\u7edf\u8ba1\u663e\u8457\u6027\u4ec5\u9650\u4e8e\u80f8\u8154\u6e7f\u58f0\uff08<em>p<\/em>&lt;0.01\uff09\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">61<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u652f\u6c14\u7ba1\u708e\u60a3\u8005\u547c\u5438\u529f\u80fd\u68c0\u6d4b\u663e\u793aNAC\u57281\u79d2\u5185\u663e\u8457\u589e\u52a0\u7528\u529b\u547c\u6c14\u91cf\uff08FEV<sub>1<\/sub>;\u4ee5L\/s\u8868\u793a\uff09\uff08<em>p<\/em>&lt;0.05\uff09\u53ca\u6cbb\u7597\u7ed3\u675f\u65f6\u7684Tiffeneau\u6307\u6570\uff08FEV<sub>1<\/sub>\/\u80ba\u6d3b\u91cf\u00d7100\uff09\uff08<em>p<\/em>&lt;0.001\uff09\uff0c\u76f8\u6bd4\u57fa\u7ebf\u7ec4\uff0c\u5b89\u6170\u5242\u7ec4\u5219\u65e0\u663e\u8457\u6539\u5584\u3002\u6c14\u7ba1\u708e\u60a3\u8005\u4e2d\uff0cNAC\u548c\u5b89\u6170\u5242\u5747\u6539\u5584\u4e86\u80ba\u6d3b\u91cf\u548cFEV<sub>1<\/sub>;\u7136\u800c\uff0cNAC\u7ec4\u7684\u6539\u5584\u66f4\u5177\u7edf\u8ba1\u5b66\u610f\u4e49\uff0cFEV<sub>1<\/sub>\u662f\u4e24\u7ec4\u6cbb\u7597\u95f4\u552f\u4e00\u663e\u8457\u5dee\u5f02\u7684\u53c2\u6570\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">61<\/a><\/p>\n<p class=\"wp-block-paragraph\">Fiocchi\u7b49\u4eba\u968f\u540e\u5bf9\u8be5\u7814\u7a76\u8fdb\u884c\u4e86\u5206\u6790\uff0cChalumeau\u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">62<\/a>\u5c06\u652f\u6c14\u7ba1\u708e\u548c\u6c14\u7ba1\u708e\u4e9a<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b62-dic-2025-7-7\"><\/a>\u7ec4\u7684\u7ed3\u679c\u5408\u5e76\uff0c\u5e76\u91c7\u7528\u6807\u51c6\u5316\u7edf\u8ba1\u65b9\u6cd5\u91cd\u65b0\u5206\u6790\uff0c\u4ee5\u786e\u4fdd\u5404\u7814\u7a76\u95f4\u7684\u4e00\u81f4\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0cNAC\u5c06\u80f8\u690e\u51cf\u9aa8\u5b66\u6539\u53d8\u7684\u98ce\u9669\u964d\u4f4e\u4e8683%\uff08\u98ce\u9669\u6bd40.17,95%\u7f6e\u4fe1\u533a\u95f40.03\u20130.99\uff09\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b62-dic-2025-7-7\">62<\/a>&nbsp;\u8fd9\u4e9b\u6539\u53d8\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\u7684\u98ce\u9669\u5dee\u4e3a\u221214%\uff0895% CI \u221225%\u81f3\u22123%\uff09\uff0c\u6cbb\u7597\u6240\u9700\u4eba\u6570\u4e3a8\uff0895% CI 4\u201334\uff09\u3002\u867d\u7136NAC\u51cf\u5c11\u4e86\u4ea7\u54b3\u7684\u53d1\u751f\uff0c\u4f46\u8fd9\u4e00\u6548\u5e94\u5728\u7edf\u8ba1\u5b66\u4e0a\u5e76\u4e0d\u663e\u8457\uff08\u98ce\u9669\u5dee\u22128%\uff0c95%\u7f6e\u4fe1\u533a\u95f4\u221220%\u81f33%\uff09\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b62-dic-2025-7-7\">62<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u5728\u53e6\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0cBiscatti\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b21-dic-2025-7-7\">\u4eba\u8bc4\u4f30\u4e86<\/a>\u53e3\u670dNAC\u5728\u6025\u6027\u547c\u5438\u9053\u611f\u67d3\u60a3\u8005\uff08\u5305\u62ec\u80ba\u708e\uff08<em>n<\/em>=18\uff09\u3001\u652f\u6c14\u7ba1\u708e\uff08<em>n<\/em>=28\uff09\u548c\u6c14\u7ba1\u708e\uff08<em>n<\/em>=4\uff09\u4e2d\u7684\u8f85\u52a9\u4f7f\u7528\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u300250\u540d\u513f\u7ae5\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u5355\u7528\u6297\u751f\u7d20\uff08<em>n<\/em>=25\uff09\u6216\u8054\u5408\u6297\u751f\u7d20\u8054\u5408NAC\uff08<em>n<\/em>=25\uff09\u3002NAC\u5242\u91cf\u4f9d\u5e74\u9f84\u800c\u5f02\uff1a2\u5c81\u4ee5\u4e0b\u513f\u7ae5\u6bcf\u5929100\u6beb\u514b\uff0c2\u81f34\u5c81\u513f\u7ae5\u6bcf\u5929200\u6beb\u514b\uff0c4\u5c81\u4ee5\u4e0a\u513f\u7ae5\u6bcf\u5929300\u6beb\u514b\u3002\u6cbb\u7597\u53e3\u670d\uff0c\u6301\u7eed6\u5929\u3002\u4e34\u5e8a\u7597\u6548\u57fa\u4e8e\u53d1\u70ed\u3001\u80f8\u8154\u542c\u8bca\u3001\u547c\u5438\u56f0\u96be\u548c\u54b3\u55fd\u7684\u53d8\u5316\u3002\u63a5\u53d7NAC\u6cbb\u7597\u7684\u513f\u7ae5\u53d1\u70e7\u548c\u80f8\u690e\u5f02\u5e38\u7684\u7f13\u89e3\u901f\u5ea6\u6bd4\u5355\u7528\u6297\u751f\u7d20\u7684\u513f\u7ae5\u66f4\u5feb\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#f2-dic-2025-7-7\">\u89c1\u56fe2<\/a>\uff09\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b21-dic-2025-7-7\">21<\/a><\/p>\n<figure class=\"wp-block-image\" id=\"f2-dic-2025-7-7\"><a class=\"tileshop\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=12657002_DIC-2025-7-7-BENEDETTI-Figure2.jpg\" data-lightbox=\"image_lg\"><img title=\"NAC\u5728\u513f\u79d1\u4e2d\u7684\u5e94\u7528\uff1a\u547c\u5438\u62a4\u7406\u4e2d\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u5242\u91cf\u7b56\u7565\u7efc\u8ff0 - \u7b2c2\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"NAC\u5728\u513f\u79d1\u4e2d\u7684\u5e94\u7528\uff1a\u547c\u5438\u62a4\u7406\u4e2d\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u5242\u91cf\u7b56\u7565\u7efc\u8ff0 - \u7b2c2\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\"  width=\"798\" height=\"149\"  data-src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;798&#039;%20height=&#039;149&#039;%20viewBox=&#039;0%200%20798%20149&#039;%3E%3C\/svg%3E\" class=\"wp-image-9791 perfmatters-lazy\" data-src=\"https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2025\/12\/DIC-2025-7-7-BENEDETTI-Figure2.jpg\" data-srcset=\"https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2025\/12\/DIC-2025-7-7-BENEDETTI-Figure2.jpg 798w, https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2025\/12\/DIC-2025-7-7-BENEDETTI-Figure2-300x56.jpg 300w, https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2025\/12\/DIC-2025-7-7-BENEDETTI-Figure2-768x143.jpg 768w\" data-sizes=\"(max-width: 798px) 100vw, 798px\" \/><img loading=\"lazy\" decoding=\"async\" title=\"NAC\u5728\u513f\u79d1\u4e2d\u7684\u5e94\u7528\uff1a\u547c\u5438\u62a4\u7406\u4e2d\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u5242\u91cf\u7b56\u7565\u7efc\u8ff0 - \u7b2c3\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"NAC\u5728\u513f\u79d1\u4e2d\u7684\u5e94\u7528\uff1a\u547c\u5438\u62a4\u7406\u4e2d\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u5242\u91cf\u7b56\u7565\u7efc\u8ff0 - \u7b2c3\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" width=\"798\" height=\"149\" src=\"https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2025\/12\/DIC-2025-7-7-BENEDETTI-Figure2.jpg\" class=\"wp-image-9791\" \/><\/a><figcaption class=\"wp-element-caption\">N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\uff08NAC\uff09\u5728\u51cf\u8f7b\u6025\u6027\u547c\u5438\u9053\u611f\u67d3\u513f\u7ae5\u547c\u5438\u9053\u75c7\u72b6\u65b9\u9762\u7684\u7597\u6548\uff08\u636eBiscatti\u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b21-dic-2025-7-7\">21<\/a>\u9879\u4fee\u6b63\uff09\u3002\u539f\u8bba\u6587<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b21-dic-2025-7-7\">21<\/a>\u7684\u4f5c\u8005\u4f7f\u7528Wilcoxon\u68c0\u9a8c\uff08\u00b0<em>p<\/em>=0.05;\u00b0<em>\u00b0p<\/em>=0.005\uff09\u5bf9\u6301\u4e45\u6027\u66f2\u7ebf\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002<sup>\u00a7<\/sup>\u5b89\u6170\u5242\uff1a\u5355\u72ec\u4f7f\u7528\u6297\u751f\u7d20;<sup>\u00a7\u00a7<\/sup>NAC\uff1a\u6297\u751f\u7d20+NAC\u3002<\/figcaption><\/figure>\n<p class=\"wp-block-paragraph\">Hashemian\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b63-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u968f\u673a\u7814\u7a76\uff0c\u9488\u5bf958\u540d8\u81f318\u5c81\u3001\u4f34\u6709\u4e2d\u5ea6COVID-19\u75c7\u72b6\u7684\u513f\u79d1\u60a3\u8005\u3002\u53c2\u4e0e\u8005\u63a5\u53d7\u53e3\u670dNAC\uff081200\u6beb\u514b\/\u5929\uff09\u6216\u5b89\u6170\u5242\uff0c\u8fde\u7eed7\u5929\uff0c\u914d\u5408\u56fd\u5bb6\u65b0\u51a0\u6cbb\u7597\u65b9\u6848\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u8bc4\u4f30\u4e86C\u53cd\u5e94\u86cb\u767d\uff08CRP\uff09\u6c34\u5e73\u3001\u767d\u7ec6\u80de\uff08WBC\uff09\u8ba1\u6570\u3001\u8840\u6e05\u808c\u9150\u3001\u8840\u6c27\u9971\u548c\u5ea6\u3001\u4f4f\u9662\u65f6\u95f4\u53ca\u4e34\u5e8a\u75c7\u72b6\u3002\u4e24\u7ec4\u6240\u6709\u6d4b\u91cf\u53d8\u91cf\u5728\u7814\u7a76\u7ed3\u675f\u65f6\u5747\u663e\u793a\u663e\u8457\u6539\u5584\u3002\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0cNAC\u663e\u8457\u6539\u5584\u4e86\u8840\u6c27\u9971\u548c\u5ea6\uff08<em>p<\/em>=0.001\uff09\u548c\u7f29\u77ed\u4f4f\u9662\u65f6\u95f4\uff08<em>p<\/em>=0.001\uff09\u3002\u867d\u7136CRP\u548c\u767d\u7ec6\u80de\u7684\u53d8\u5316\u672a\u663e\u8457\uff0c\u4f46NAC\u7ec4\u7684\u6b7b\u4ea1\u7387\u4f4e\u4e8e\u5b89\u6170\u5242\u7ec4\uff087.4%\uff09\uff0c\u5c3d\u7ba1\u8be5\u5dee\u5f02\u4e0d\u663e\u8457\uff08<em>p<\/em>=0.491\uff09\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b63-dic-2025-7-7\">63<\/a><\/p>\n<p class=\"wp-block-paragraph\">Trastotenojo\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b64-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\uff0c\u8bc4\u4f30\u53e3\u670dNAC\u5728\u60a3\u6709\u591a\u79cd\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u513f\u79d1\u60a3\u8005\u4e2d\u7684\u7597\u6548\uff0c\u5305\u62ec\u652f\u6c14\u7ba1\u80ba\u708e\uff0820\u7ec4NAC\uff0c18\u7ec4\u5b89\u6170\u5242\uff09\u3001\u652f\u6c14\u7ba1\u54ee\u5598\uff085\u7ec4NAC\uff0c4\u7ec4\u5b89\u6170\u5242\u7ec4\uff09\u3001\u652f\u6c14\u7ba1\u708e\uff083\u7ec4NAC\uff0c2\u7ec4\u5b89\u6170\u5242\uff09\u548c\u7ed3\u6838\u75c5\uff082\u7ec4NAC\uff0c\u96f6\u7ec4\u5b89\u6170\u5242\u7ec4\uff09\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b64-dic-2025-7-7\">\u503c\u5f97\u6ce8\u610f\u7684\u662f<\/a>\uff0c\u867d\u7136\u8be5\u7814\u7a76\u88ab\u63cf\u8ff0\u4e3a\u53cc\u76f2\u4e14\u5b89\u6170\u5242\u5bf9\u7167\uff0c\u4f46\u672a\u660e\u786e\u62a5\u544a\u968f\u673a\u5206\u7ec4\u3002\u8be5\u7814\u7a76\u6700\u521d\u62db\u52df\u4e8660\u540d\u5e74\u9f84\u57282\u4e2a\u6708\u81f313\u5c81\u4e4b\u95f4\u7684\u513f\u7ae5\uff0c\u4f46\u7531\u4e8e\u4e24\u4f8b\u6b7b\u4ea1\u548c\u56db\u4f8b\u672a\u7ecf\u540c\u610f\u51fa\u9662\uff0c\u516d\u4f8b\u88ab\u6392\u9664\u3002\u6700\u7ec8\u5206\u6790\u5305\u62ec\u63a5\u53d7NAC\uff08\u6bcf\u65e5\u4e09\u6b21\uff0c\u6bcf\u6b21100\u6beb\u514b\uff0c\u6301\u7eed5\u5929\uff09\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5e76\u5728\u5fc5\u8981\u65f6\u4f7f\u7528\u6297\u751f\u7d20\u548c\u652f\u6c14\u7ba1\u6269\u5f20\u5242\u7b49\u6807\u51c6\u6cbb\u7597\u3002\u4e34\u5e8a\u7ed3\u5c40\u901a\u8fc7\u54b3\u55fd\u3001\u547c\u5438\u56f0\u96be\u3001\u542c\u8bca\u3001\u8840\u6db2\u68c0\u67e5\u548c\u80f8\u90e8X\u5149\u7b49\u6307\u6807\u8bc4\u4f30\u3002\u5728\u652f\u6c14\u7ba1\u80ba\u708e\u513f\u7ae5\u4e2d\uff0cNAC\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u5728\u4e2a\u522b\u65f6\u95f4\u70b9\u7684\u5934\u5bf9\u4e00\u6bd4\u8f83\u4e2d\u672a\u89c2\u5bdf\u5230\u663e\u8457\u5dee\u5f02\u3002\u7136\u800c\uff0c\u5728\u5206\u6790\u6574\u4f53\u6cbb\u7597\u8fdb\u5c55\u65f6\uff0cNAC\u57281\u30013\u30015\u548c7\u5929\u4e4b\u95f4\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u663e\u8457\u7684\u6539\u5584\uff08<em>p<\/em>&lt;0.05\uff09\uff0c\u8fd9\u4e00\u6548\u5e94\u5728\u5b89\u6170\u5242\u7ec4\u4e2d\u672a\u89c1\u3002\u5728\u4e9a\u6025\u6027\u80ba\u5fc3\u6838\u5e76\u53d1\u75c7\u652f\u6c14\u7ba1\u80ba\u708e\u60a3\u8005\u4e2d\uff0cNAC\u5728\u7b2c7\u5929\u624d\u6709\u663e\u8457\u6539\u5584\uff08<em>p<\/em>&lt;0.05\uff09\u3002\u5728\u652f\u6c14\u7ba1\u54ee\u5598\u75c5\u4f8b\u4e2d\uff0cNAC\u5728\u4efb\u4f55\u5355\u4e00\u65f6\u95f4\u70b9\u5747\u672a\u4ea7\u751f\u7edf\u8ba1\u5b66\u4e0a\u663e\u8457\u7684\u53d8\u5316\u3002\u7136\u800c\uff0c\u5728\u8003\u8651\u7d2f\u79ef\u6cbb\u7597\u6548\u679c\u65f6\uff0c\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u652f\u6c14\u7ba1\u80ba\u708e\u548c\u652f\u6c14\u7ba1\u54ee\u5598\u7684\u54b3\u55fd\u5206\u6790\u663e\u793a\uff0cNAC\u7ec4\u7684\u4e25\u91cd\u7a0b\u5ea6\u8f83\u5b89\u6170\u5242\u663e\u8457\u964d\u4f4e\uff08<em>p<\/em>&lt;0.05\uff09\u3002NAC\u6cbb\u7597\u652f\u6c14\u7ba1\u80ba\u708e\u60a3\u8005\u7684\u547c\u5438\u56f0\u96be\u8fc5\u901f\u6539\u5584\uff0c\u7b2c1\u30013\u548c7\u5929\u663e\u8457\u663e\u8457\uff08<em>p<\/em>&lt;0.05\uff09\u3002\u7531\u4e8e\u6837\u672c\u91cf\u8f83\u5c0f\uff0c\u5bf9\u7ec6\u652f\u6c14\u7ba1\u708e\u548c\u7ed3\u6838\u75c5\u60a3\u8005\u8fdb\u884c\u7edf\u8ba1\u5206\u6790\u4e0d\u53ef\u884c\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b64-dic-2025-7-7\">64<\/a>&nbsp;\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u5c3d\u7ba1NAC\u5728\u4e2a\u4f53\u6bcf\u65e5\u65f6\u95f4\u70b9\u53ef\u80fd\u672a\u660e\u663e\u4f18\u4e8e\u5b89\u6170\u5242\uff0c\u4f46\u5728\u8bc4\u4f30\u6574\u4f53\u6cbb\u7597\u8fdb\u5c55\u65f6\uff0c\u5176\u76ca\u5904\u6548\u679c\u53d8\u5f97\u66f4\u52a0\u660e\u663e\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cNAC\u65bd\u7528\u65f6\u95f4\u8d8a\u957f\uff0c\u89c2\u5bdf\u5230\u7684\u6539\u5584\u8d8a\u660e\u663e\uff0c\u8fdb\u4e00\u6b65\u5f3a\u5316\u4e86\u5176\u957f\u671f\u6f5c\u5728\u7684\u7d2f\u79ef\u6cbb\u7597\u76ca\u5904\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b64-dic-2025-7-7\">64<\/a><\/p>\n<h4 class=\"wp-block-heading\">\u968f\u673a\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76<\/h4>\n<p class=\"wp-block-paragraph\">Bellomo \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b65-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u5f00\u653e\u3001\u968f\u673a\u5bf9\u7167\u6bd4\u8f83\u7814\u7a76\uff0c\u8bc4\u4f30\u4e8650\u540d\u6025\u6027\u652f\u6c14\u7ba1\u708e\uff08<em>n<\/em>=20\uff09\u6216\u80ba\u708e\uff08<em>n<\/em>=30\uff09\u513f\u7ae5\u4e2d\u808c\u5185\u6ce8\u5c04<em>\u4e0e<\/em>\u53e3\u670dNAC\u7684\u7597\u6548\uff0c\u5176\u4e2d\u5305\u62ec35\u540d2\u5c81\u4ee5\u4e0b\u513f\u7ae5\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u60a3\u8005\u5206\u4e3a\u4e24\u7ec4\uff1a25\u4eba\u63a5\u53d7\u53e3\u670dNAC\uff08Fluimucil\uff0c100\u6beb\u514b\u5c0f\u5305\u621610%\u6eb6\u6db2\uff09\uff0c\u53e6\u591625\u4eba\u63a5\u53d7\u808c\u8089\u6ce8\u5c04NAC\uff08300\u6beb\u514b\/3\u6beb\u5347\uff09\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b65-dic-2025-7-7\">65<\/a>&nbsp;\u4e24\u7ec4\u540c\u65f6\u63a5\u53d7\u6297\u751f\u7d20\u6cbb\u7597\uff08\u94fe\u9709\u7d20\u548c\u786b\u82ef\u5c3c\u9187\uff09\u3002\u5242\u91cf\u6309\u5e74\u9f84\u8c03\u6574\uff1a2\u5c81\u4ee5\u4e0b\u513f\u7ae5\u6bcf\u5929300\u6beb\u514b\uff08\u53e3\u670d\u6216\u808c\u8089\u6ce8\u5c04\uff09\uff0c2\u5c81\u4ee5\u4e0a\u513f\u7ae5\u6bcf\u5929600\u6beb\u514b\u3002\u6cbb\u7597\u6301\u7eed\u4e86\u6700\u957f8\u5929\u3002\u8bc4\u4f30\u4e86\u4e34\u5e8a\u7ed3\u5c40\uff0c\u5305\u62ec\u53d1\u70ed\u3001\u547c\u5438\u56f0\u96be\u3001\u80f8\u8154\u542c\u8bca\u548c\u54b3\u55fd\u3002NAC\u5728\u4e24\u79cd\u7ed9\u836f\u65b9\u5f0f\u4e0b\u6548\u679c\u76f8\u5f53\uff0c\u6240\u6709\u8bc4\u4f30\u53c2\u6570\u5747\u6709\u663e\u8457\u6539\u5584\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b65-dic-2025-7-7\">65<\/a><\/p>\n<p class=\"wp-block-paragraph\">Camurri\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b66-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u6d89\u53ca32\u540d2\u81f311\u5c81\u6025\u6027\u652f\u6c14\u7ba1\u708e\u513f\u7ae5\uff0c\u6bd4\u8f83\u53e3\u670dNAC\uff08300\u6beb\u514b\/\u5929\uff09\u4e0e\u6eb4\u5df1\u5b9a\uff0848\u6beb\u514b\/\u5929\uff09\u572810\u5929\u5185\u670d\u7528\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u4e24\u79cd\u6cbb\u7597\u5747\u6539\u5584\u4e86\u4e34\u5e8a\u75c7\u72b6\uff0c\u4f46\u6eb4\u5df1\u5b9a\u7684\u6cbb\u7597\u6548\u679c\u66f4\u4f18\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b66-dic-2025-7-7\">66<\/a><\/p>\n<p class=\"wp-block-paragraph\">Chen\u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b67-dic-2025-7-7\">67<\/a>\u7814\u7a76\u4e86120\u540d\u80ba\u708e<em>\u652f\u539f\u4f53<\/em>\u80ba\u708e\u513f\u7ae5\u4e2d\u6c14\u6eb6\u80f6\u5316NAC\u548c\u5e03\u5730\u5948\u5fb7\u7684\u8054\u5408\u4f7f\u7528\u60c5\u51b5\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u5b9e\u9a8c\u7ec4\uff08\u5e73\u5747\u5e74\u9f847.27\u00b12.47\u5c81\uff09\u540c\u65f6\u63a5\u53d7NAC\u548c\u5e03\u5730\u5948\u5fb7\uff08\u6c14\u6eb6\u80f6\u5e03\u5730\u5948\u5fb7\uff0c\u5242\u91cf\uff1a0.25\u20130.5\u6beb\u514b;\u9891\u7387\uff1a\u6bcf\u6b2110\u5206\u949f\uff0c\u6bcf\u65e5\u4e24\u6b21;\u6c27\u6c14\u6d41\u91cf\uff1a5\u5347\/\u5206\u949f\uff09\u548cNAC\uff08\u6bcf\u6b213\u6beb\u5347\uff0c\u6bcf\u59292\u81f33\u6b21\uff09\uff0c\u800c\u5bf9\u7167\u7ec4\uff08\u5e73\u5747\u5e74\u9f84\uff1a7.02\u00b12.58\u5c81\uff09\u5355\u72ec\u670d\u7528\u5e03\u5730\u5948\u5fb7\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b67-dic-2025-7-7\">67<\/a>&nbsp;\u7ecf\u8fc7\u4e24\u5468\u6cbb\u7597\uff0c<mark class=\"has-inline-color has-vivid-red-color\">NAC\u7ec4\u54b3\u55fd\u3001\u53d1\u70ed\u548c\u6e83\u75a1\u7684\u7f13\u89e3\u66f4\u5feb\u3002\u6b64\u5916\uff0cNAC\u7ec4\u5728\u708e\u75c7\u6807\u5fd7\u7269\uff08IL-6\u3001TNF\u548cCRP\uff09\u65b9\u9762\u8f83\u5bf9\u7167\u7ec4\u663e\u8457\u51cf\u5c11\u3002NAC\u7ec4\u7684\u603b\u6709\u6548\u7387\u4e3a98.33%\uff0c\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u768493.33%\u3002<\/mark><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b67-dic-2025-7-7\">67<\/a><\/p>\n<p class=\"wp-block-paragraph\">Xue\u7b49\u4eba\u968f\u673a\u5206\u914d<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b68-dic-2025-7-7\"><\/a>\u4e8698\u540d2\u81f36\u5c81\u80ba\u708e\u513f\u7ae5\uff0c\u63a5\u53d7NAC\uff083\u6beb\u5347\uff1a300\u6beb\u514b\u6eb6\u89e3\u4e8e3\u6beb\u53470.9%\u6c2f\u5316\u94a0\u6eb6\u6db2\u4e2d\uff09\u6216\u76d0\u9178\u5b89\u5e03\u7f57\u6614\uff08300\u6beb\u514b\/\u7247\uff0c\u4e00\u7247\u6eb6\u4e8e3\u6beb\u53470.9%\u6c2f\u5316\u94a0\u6eb6\u6db2\u4e2d\uff09\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u6eb6\u6db2\u88ab\u52a0\u5165\u9762\u7f69\u96fe\u5316\u5668\uff0c\u5e76\u4ee5\u8c03\u6574\u540e\u7684\u6c27\u6c14\u6d41\u91cf6\u20138\u5347\/\u5206\u949f\u8fde\u63a5\u5230\u6c27\u6c14\u88c5\u7f6e\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u6301\u7eed\u4e00\u5468\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b68-dic-2025-7-7\">NAC<\/a>\u7ec4\u548c\u5b89\u5e03\u7f57\u7d22\u5c14\u7ec4\u7684\u5e73\u5747\u5e74\u9f84\u5206\u522b\u4e3a5.28\u00b11.03\u548c5.34\u00b11.12\u5c81\u3002<mark class=\"has-inline-color has-vivid-red-color\">NAC\u7ec4\u6cbb\u7597\u6548\u679c\u66f4\u9ad8\uff0c\u53d1\u70e7\u3001\u54b3\u55fd\u548c\u80ba\u90e8\u6de4\u7ba1\u7684\u6d88\u9000\u66f4\u5feb\uff08<em>p<\/em>&lt;0.05\uff09\u3002\u6cbb\u7597\u540e\u708e\u75c7\u6807\u5fd7\u7269\uff0c\u5305\u62ecCRP\u548c\u524d\u9499\u5316\u7d20\uff0cNAC\u7ec4\u663e\u8457\u964d\u4f4e\uff08<em>p<\/em>&lt;0.05\uff09\uff0c\u800c\u80ba\u529f\u80fd\u6307\u6807\uff08\u5f3a\u8feb\u80ba\u6d3b\u91cf\uff08FVC\uff09\u3001FEV<sub>1<\/sub>\u3001FEV<sub>1<\/sub>\/FVC\uff09\u6539\u5584\uff08<em>p<\/em>&lt;0.05\uff09\u3002\u6b64\u5916\uff0cNAC\u7ec4\u8840\u6e05\u514d\u75ab\u7403\u86cb\u767d\uff08IgA\u3001IgG\u548cIgM\uff09\u548c\u8865\u4f53\u86cb\u767dC3\u6c34\u5e73\u4e5f\u66f4\u9ad8\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b68-dic-2025-7-7\">68<\/a><\/mark><\/p>\n<h4 class=\"wp-block-heading\">\u975e\u968f\u673a\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76<\/h4>\n<p class=\"wp-block-paragraph\">Seidita\u7b49\u4eba\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b69-dic-2025-7-7\">69<\/a>\uff09\u6bd4\u8f83\u4e8640\u540d3\u81f312\u5c81\u6025\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u513f\u7ae5\uff08\u5305\u62ec\u652f\u6c14\u7ba1\u708e\u548c\u54bd\u6c14\u7ba1\u652f\u6c14\u7ba1\u708e\uff09\u7684\u53e3\u670dSobrerol\u4e0e\u53e3\u670dNAC\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u88681<\/a>\uff09\u3002\u7d22\u5e03\u7f57\u5c14\u4ee5\u9897\u7c92\u5f62\u5f0f\uff0c\u5355\u5242\u91cf\u5c0f\u5305\uff08100\u6beb\u514b\uff09\u6bcf\u65e5\u4e09\u6b21\uff0c\u8fde\u7eed3\u5929\u670d\u7528\u3002NAC\u9897\u7c92\u4ee5\u6bcf\u5929300\u6beb\u514b\u7684\u5242\u91cf\u7ed9\u836f\uff0c\u6301\u7eed3\u5929\u3002\u4e34\u5e8a\u53c2\u6570\u548c\u751f\u7269\u6570\u636e\uff0c\u5305\u62ec\u5410\u75f0\u7684\u6d41\u53d8\u5b66\u5206\u6790\uff0c\u5747\u5728\u57fa\u7ebf\u548c\u6cbb\u7597\u7ed3\u675f\u65f6\u8fdb\u884c\u8bc4\u4f30\u3002\u4e24\u79cd\u6cbb\u7597\u5747\u57283\u5929\u7597\u7a0b\u5185\u6709\u6548\uff0c\u7d22\u5e03\u7f57\u5c14\u5728\u75f0\u6db2\u7c98\u5ea6\u964d\u4f4e\u65b9\u9762\u7565\u4f18\uff0c\u8010\u53d7\u6027\u4f18\u4e8eNAC\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b69-dic-2025-7-7\">69<\/a>&nbsp;\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u76d1\u7ba1\u673a\u6784\u6700\u8fd1\u901a\u8fc7\u5c06\u6240\u6709\u914d\u65b9\u7684\u63a8\u8350\u6cbb\u7597\u65f6\u95f4\u7f29\u77ed\u81f33\u5929\uff0c\u9650\u5236\u4e86\u7d22\u5e03\u7f57\u5c14\u7684\u4f7f\u7528\uff0c\u539f\u56e0\u662f\u67d0\u4e9b\u60a3\u8005\u51fa\u73b0\u4e86\u4e0d\u826f\u795e\u7ecf\u7cfb\u7edf\u53cd\u5e94\u7684\u62a5\u544a\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b70-dic-2025-7-7\">70<\/a><\/p>\n<p class=\"wp-block-paragraph\">Liu\u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b71-dic-2025-7-7\">71<\/a>\u5bf9\u6bd4\u4e86NAC\u548c\u76d0\u9178\u5b89\u5e03\u7f57\u916e\u5728120\u540d\u652f\u6c14\u7ba1\u80ba\u708e\u513f\u7ae5\u4e2d\u7684\u6548\u679c\u3002\u7814\u7a76\u7eb3\u5165\u4e86NAC\u7ec458\u540d\u513f\u7ae5\uff08\u5e73\u5747\u5e74\u9f844.6\u5c81\uff0c\u8303\u56f41\u20137\u5c81\uff09\u53ca62\u540d\u63a5\u53d7\u76d0\u9178\u5b89\u5e03\u7f57\u6614\u7684\u5bf9\u7167\u7ec4\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b71-dic-2025-7-7\">71<\/a>&nbsp;NAC\u901a\u8fc7\u5c063 mL NAC\u4e0e\u7ea63 mL 10%\u6c2f\u5316\u94a0\u7a00\u91ca\u7ed9\u836f\uff0c\u800c\u76d0\u9178\u5b89\u5e03\u7f57\u6614\u5219\u901a\u8fc7\u5c06\u4e00\u7247\u5b89\u5e03\u7f57\u6614\u6eb6\u89e3\u57283\u6beb\u53470.9%\u6c2f\u5316\u94a0\u4e2d\u5236\u5907\u3002\u4e24\u79cd\u6eb6\u6db2\u5747\u901a\u8fc7\u8fde\u63a5\u6c27\u6c14\u88c5\u7f6e\u7684\u96fe\u5316\u7f69\u8f93\u9001\u3002\u6c27\u6c14\u6d41\u91cf\u8c03\u6574\u4e3a7\u5347\/\u5206\u949f\uff0c\u5e76\u8fdb\u884c\u6bcf\u65e5\u4e24\u6b21\u96fe\u5316\u5438\u5165\u3002\u6bcf\u6b21\u5438\u5165\u542b3\u6beb\u5347NAC\u62162\u6beb\u5347\u5b89\u5e03\u7f57\u7d22\u3002\u6cbb\u7597\u5206\u4e3a\u4e24\u7597\u7a0b\uff0c\u6bcf\u7597\u7a0b\u6301\u7eed\u4e00\u5468\u3002\u4e3b\u8981\u7ec8\u70b9\u5305\u62ec\u53d1\u70ed\u3001\u54b3\u55fd\u3001\u54ee\u5598\u3001\u80ba\u90e8\u80bf\u5757\u7b49\u5173\u952e\u75c7\u72b6\u7684\u6d88\u5931\u65f6\u95f4\u4ee5\u53ca\u6574\u4f53\u4f4f\u9662\u65f6\u95f4\u3002\u514d\u75ab\u529f\u80fd\u6807\u5fd7\u7269\uff0c\u5305\u62ecIgA\u3001IgG\u548cIgM\uff0c\u4ee5\u53ca\u8865\u4f53\u86cb\u767dC3\u548cC4\uff0c\u5747\u5728\u6cbb\u7597\u524d\u540e\u5747\u88ab\u6d4b\u91cf\u3002NAC\u7ec4\u7684\u6709\u6548\u7387\u663e\u8457\u9ad8\u4e8e\u5b89\u5e03\u7f57\u7d22\u5c14\u7ec4\uff0894.83% \u5bf9 82.26%;<em>\u7b2c&lt;0.05\u9875<\/em>\uff09\u3002NAC\u7ec4\u7684\u53d1\u70ed\u3001\u54b3\u55fd\u3001\u54ee\u5598\u3001\u80ba\u90e8\u6e83\u75a1\u548c\u5f02\u5e38\u80baX\u5149\u68c0\u67e5\u6d88\u5931\u65f6\u95f4\u663e\u8457\u7f29\u77ed\u4e8e\u5bf9\u7167\u7ec4\uff08<em>p<\/em>&lt;0.05\uff09\u3002\u4e24\u79cd\u6cbb\u7597\u5747\u5bfc\u81f4\u6cbb\u7597\u540eIgA\u3001IgG\u548cIgM\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff08<em>p<\/em>&lt;0.01\uff09\uff0c\u4f46NAC\u7ec4\u7684IgA\u548cIgG\u663e\u8457\u5347\u9ad8\u4e8e\u5b89\u5e03\u6d1b\u7d22\u5c14\u7ec4\uff08<em>p<\/em>&lt;0.01\uff09\u3002\u6b64\u5916\uff0cNAC\u7ec4\u7684\u751f\u6d3b\u8d28\u91cf\u6307\u6807\uff0c\u5305\u62ec\u751f\u7406\u529f\u80fd\u3001\u8eaf\u4f53\u75bc\u75db\u3001\u6574\u4f53\u5065\u5eb7\u72b6\u51b5\u548c\u6d3b\u529b\u8bc4\u5206\uff0c\u5747\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b71-dic-2025-7-7\">71<\/a><\/p>\n<h3 class=\"wp-block-heading\">\u975e\u5bf9\u7167\u6216\u56de\u987e\u6027\u4e34\u5e8a\u7814\u7a76<\/h3>\n<p class=\"wp-block-paragraph\">Bellomo \u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b18-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u7814\u7a76\uff0c\u6d89\u53ca39\u540d2\u4e2a\u6708\u81f311\u5c81\u7684\u4e25\u91cd\u652f\u6c14\u7ba1\u80ba\u611f\u67d3\u513f\u7ae5\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t2-dic-2025-7-7\">\u89c1\u88682<\/a>\uff09\u3002\u53c2\u4e0e\u8005\u63a5\u53d7\u4e86\u6297\u751f\u7d20-\u9ecf\u6db2\u6eb6\u89e3\u5242\u7ec4\u5408\uff0c\u5305\u62ec\u786b\u82ef\u5c3c\u9187\u7518\u6c28\u9178\uff0822\u201340 mg\/kg\/\u5929\uff09\u548c\u4e59\u9170\u534a\u6c28\u9178\uff0810\u201318 mg\/kg\/\u5929\uff09\uff0c\u901a\u8fc7\u808c\u8089\u6ce8\u5c04\u7ed9\u836f\uff0c\u6301\u7eed4\u201318\u5929\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b18-dic-2025-7-7\">18<\/a>&nbsp;\u6240\u6709\u60a3\u8005\u5747\u8868\u73b0\u51fa\u53d1\u70e7\uff082.61\u5929\uff09\u3001\u547c\u5438\u56f0\u96be\uff08\u5305\u62ec\u53d1\u7ec0\u75c7\u72b6\uff0c2.42\u5929\uff09\u3001\u54b3\u55fd\uff085.41\u5929\uff09\u548c\u80f8\u90e8\u542c\u8bca\u9633\u6027\uff085.16\u5929\uff09\u7684\u5feb\u901f\u4e14\u5b8c\u5168\u7f13\u89e3\u3002X\u5149\u7ed3\u679c\u8bc1\u5b9e\u4e86\u8be5\u7ec4\u5408\u7684\u5feb\u901f\u4e14\u5b8c\u5168\u7684\u6cbb\u7597\u6548\u679c\u3002\u4f5c\u8005\u62a5\u544a\u79f0\uff0c\u5c3d\u7ba1\u672c\u7814\u7a76\u4e2d\u8be5\u75c5\u8f83\u4e25\u91cd\uff0c\u5355\u7528\u786b\u82ef\u5c3c\u9ad8\u5c14\u7684\u7597\u6548\u548c\u901f\u5ea6\u5747\u6709\u6240\u63d0\u5347\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b18-dic-2025-7-7\">18<\/a><\/p>\n<p class=\"wp-block-paragraph\">Santangelo\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b19-dic-2025-7-7\">\u4eba\u8bc4\u4f30\u4e86<\/a>103\u540d2\u4e2a\u6708\u81f311\u5c81\u88ab\u8bca\u65ad\u4e3a\u4e0b\u547c\u5438\u9053\u611f\u67d3\u7684\u513f\u7ae5\uff0c\u63a5\u53d7\u5934\u5b62\u544b\u8f9b\u548c\u808c\u8089\u5185NAC\uff0820\u201330 mg\/kg\/\u5929\uff09\u8054\u5408\u6cbb\u7597\uff0c\u6301\u7eed5\u81f310\u5929\u7684\u4e34\u5e8a\u7ed3\u5c40\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t2-dic-2025-7-7\">\u89c1\u88682<\/a>\uff09\u3002100\u4f8b\u60a3\u8005\u4e34\u5e8a\u53cd\u5e94\u79ef\u6781\uff0c58\u4f8b\u75c7\u72b6\u5b8c\u5168\u6d88\u5931\uff0c42\u4f8b\u663e\u8457\u6539\u5584\u3002\u80f8\u90e8X\u5149\u786e\u8ba4\u8fd9\u4e9b\u60a3\u8005\u5747\u5df2\u5eb7\u590d\u6216\u663e\u8457\u6539\u5584\u3002\u5fae\u751f\u7269\u5b66\u5206\u6790\u663e\u793a\uff0c\u6cbb\u7597\u524d\u5206\u79bb\u768472\u79cd\u81f4\u75c5\u83cc\u682a\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\u5747\u672a\u68c0\u6d4b\u5230\uff0c<mark class=\"has-inline-color has-vivid-red-color\">\u8fd9\u8868\u660eNAC\u53ef\u80fd\u5177\u6709\u8f85\u52a9\u6297\u83cc\u4f5c\u7528\u3002<\/mark><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b19-dic-2025-7-7\">19<\/a><\/p>\n<p class=\"wp-block-paragraph\">Zanasi\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b20-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u5f00\u653e\u7684\u56de\u987e\u6027\u7814\u7a76\uff0c\u6d89\u53ca59\u540d3\u81f314\u5c81\u7684\u6025\u6027\u4e0a\u547c\u5438\u9053\u611f\u67d3\u4f34\u6709\u6e7f\u54b3\u7684\u513f\u7ae5\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t3-dic-2025-7-7\">\u89c1\u88683<\/a>\uff09\u3002\u8be5\u7814\u7a76\u6bd4\u8f83\u4e86\u63a5\u53d7\u53e3\u670d\u6297\u751f\u7d20\uff08\u963f\u83ab\u897f\u6797\u6216\u5927\u73af\u5185\u916f\uff09\u6cbb\u7597\u513f\u7ae5<em>\u4e0e<\/em>\u63a5\u53d7\u96fe\u5316\u9ecf\u6db2\u6d3b\u6027\u5242\uff08\u7d22\u5e03\u7f57\u5c14\u6216NAC\uff09\u513f\u7ae5\u7684\u4e34\u5e8a\u7ed3\u5c40\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b20-dic-2025-7-7\">20<\/a>&nbsp;\u63a5\u53d7\u9ecf\u6db2\u6eb6\u89e3\u5242\u6cbb\u7597\u7ec4\u5728\u4e34\u5e8a\u75c7\u72b6\uff08\u5982\u54b3\u55fd\u4e25\u91cd\u5ea6\u548c\u75f0\u6db2\u6e05\u9664\u7387\uff09\u65b9\u9762\u663e\u8457\u6539\u5584\uff0c<mark class=\"has-inline-color has-vivid-red-color\">\u4f18\u4e8e\u63a5\u53d7\u6297\u751f\u7d20\u6cbb\u7597\u7ec4\u3002<\/mark><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b20-dic-2025-7-7\">20<\/a><\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>NAC\u5728\u6162\u6027\u513f\u79d1\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u7597\u6548\u6982\u51b5<\/h2>\n<h3 class=\"wp-block-heading\">\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76<\/h3>\n<h4 class=\"wp-block-heading\">\u968f\u673a\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/h4>\n<p class=\"wp-block-paragraph\">Mitchell\u548cElliott<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b72-dic-2025-7-7\">72<\/a>\u8fdb\u884c\u4e86\u4e00\u9879\u4ea4\u53c9\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\uff0c\u4ee5\u8bc4\u4f30\u53e3\u670dNAC\u5728\u9884\u9632\u56ca\u6027\u7ea4\u7ef4\u5316\u513f\u7ae5\u80ba\u90e8\u6076\u5316\u65b9\u9762\u7684\u6f5c\u529b\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u300220\u540d\u513f\u79d1\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f8410.8\u00b15.9\u5c81\uff09\u5728\u9700\u8981\u65f6\u63a5\u53d7NAC\uff08\u6bcf\u65e5\u4e09\u6b21\uff0c\u6bcf\u6b21200\u6beb\u514b\uff09\u6216\u5b89\u6170\u5242\uff0c\u540c\u65f6\u63a5\u53d7\u6807\u51c6\u7269\u7406\u6cbb\u7597\u53ca\u6297\u751f\u7d20\u3001\u6c14\u6eb6\u80f6\u9ecf\u80f6\u6eb6\u89e3\u5242\u3001\u80f0\u9176\u548c\u7ef4\u751f\u7d20E\u8865\u5145\u7b49\u989d\u5916\u6cbb\u7597\u3002\u7814\u7a76\u8bbe\u8ba1\u5305\u62ec\u4e24\u4e2a3\u4e2a\u6708\u7684\u6cbb\u7597\u5468\u671f\uff0c\u4e2d\u95f4\u67092\u5468\u7684\u6e05\u6d17\u671f\u3002\u7b2c\u4e00\u9636\u6bb5\uff0c\u60a3\u8005\u88ab\u5206\u914d\u63a5\u53d7NAC\u6216\u5b89\u6170\u5242\uff0c\u7b2c\u4e8c\u9636\u6bb5\u5219\u8f6c\u4e3a\u66ff\u4ee3\u6cbb\u7597\u3002\u7597\u6548\u901a\u8fc7\u547c\u6c14\u5cf0\u503c\u6d41\u91cf\uff08PEFR\uff09\u3001\u75f0\u6db2\u7c98\u5ea6\u548c\u54b3\u55fd\u9891\u7387\u8bc4\u4f30\u3002NAC\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u4e4b\u95f4PEFR\u672a\u89c2\u5bdf\u5230\u663e\u8457\u5dee\u5f02\uff0c\u4e14\u4e24\u7ec4\u5747\u672a\u62a5\u544a\u4e0d\u826f\u53cd\u5e94\u30024\u540d\u60a3\u8005\u56e0\u4e0eNAC\u6cbb\u7597\u65e0\u5173\u7684\u539f\u56e0\u9000\u51fa\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b72-dic-2025-7-7\">72<\/a><\/p>\n<p class=\"wp-block-paragraph\">Stafanger\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b73-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u4ea4\u53c9\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\uff0c\u4ee5\u8bc4\u4f30\u56ca\u6027\u7ea4\u7ef4\u5316\u548c\u539f\u53d1\u776b\u72b6\u4f53\u8fd0\u52a8\u969c\u788d\uff08PCD\uff09\u60a3\u8005\u7684\u53e3\u670dNAC\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u8be5\u7814\u7a76\u5305\u62ec41\u540d\u56ca\u6027\u7ea4\u7ef4\u5316\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f849.5\u5c81\uff09\u548c13\u540d\u60a3\u6709PCD\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f8429.7\u5c81\uff09\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">74<\/a>&nbsp;NAC\u5242\u91cf\u57fa\u4e8e\u4f53\u91cd\uff1a30\u516c\u65a4\u4ee5\u4e0b\u6bcf\u5929\u4e09\u6b21200\u6beb\u514b\uff0c30\u516c\u65a4\u4ee5\u4e0a\u6bcf\u65e5\u4e24\u6b21400\u6beb\u514b\u3002\u8be5\u6cbb\u7597\u4e0e\u652f\u6c14\u7ba1\u6269\u5f20\u5242\u4e00\u540c\u8fdb\u884c\uff0c\u5206\u4e24\u4e2a\u4e09\u4e2a\u6708\u3002\u60a3\u8005\u5728\u7b2c\u4e00\u671f\u63a5\u53d7NAC\u6216\u5b89\u6170\u5242\uff0c\u7b2c\u4e8c\u671f\u8f6c\u4e3a\u66ff\u4ee3\u6cbb\u7597\uff0c\u968f\u540e\u8fdb\u884c3\u4e2a\u6708\u968f\u8bbf\u3002\u6548\u679c\u901a\u8fc7\u4e3b\u89c2\u4e34\u5e8a\u8bc4\u5206\u8bc4\u4f30\uff0c\u540c\u65f6\u8bc4\u4f30\u4f53\u91cd\u3001\u75f0\u83cc\u5b66\u3001\u8840\u767d\u7ec6\u80de\u8ba1\u6570\u3001\u6c89\u964d\u901f\u7387\u3001\u7279\u5b9a\u6297\u83cc\u6297\u4f53\u6ef4\u5ea6\u3001\u80ba\u529f\u80fd\u53c2\u6570\u548c\u776b\u72b6\u529f\u80fd\u6d4b\u91cf\u3002\u5728\u56ca\u6027\u7ea4\u7ef4\u5316\u60a3\u8005\u4e2d\uff0cNAC\u5728\u79cb\u5b63\u6539\u5584\u80ba\u529f\u80fd\uff0c\u6b64\u65f6\u4e0b\u547c\u5438\u9053\u611f\u67d3\u6700\u4e3a\u5e38\u89c1\uff0c\u4f46PCD\u60a3\u8005\u672a\u89c2\u5bdf\u5230\u663e\u8457\u6548\u679c\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b73-dic-2025-7-7\">73<\/a><\/p>\n<p class=\"wp-block-paragraph\">Stafanger\u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">74<\/a>\u901a\u8fc7\u4e00\u9879\u4ea4\u53c9\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u6269\u5c55\u4e86\u7814\u7a76\uff0c\u9488\u5bf952\u540d\u60a3\u6709\u6162\u6027\u94dc\u7eff<em>\u5047\u5355\u80de<\/em>\u83cc\u611f\u67d3\u7684\u56ca\u6027\u7ea4\u7ef4\u5316\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f8415.8\u5c81\uff09\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u60a3\u8005\u63a5\u53d7\u53e3\u670dNAC\uff0830\u516c\u65a4\u4ee5\u4e0b\u6bcf\u65e5\u4e09\u6b21200\u6beb\u514b\uff0c30\u516c\u65a4\u4ee5\u4e0a\u6bcf\u65e5\u4e24\u6b21400\u6beb\u514b\uff09\u6216\u5b89\u6170\u5242\uff0c\u914d\u5408\u6807\u51c6\u56ca\u6027\u7ea4\u7ef4\u5316\u6cbb\u7597\uff0c\u6301\u7eed3\u4e2a\u6708\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">74<\/a>&nbsp;\u901a\u8fc7\u4e3b\u89c2\u4e34\u5e8a\u8bc4\u5206\u4ee5\u53ca\u4f53\u91cd\u3001\u75f0\u83cc\u5b66\u3001\u8840\u767d\u7ec6\u80de\u8ba1\u6570\u3001\u6c89\u964d\u901f\u7387\u3001\u7279\u5b9a\u6297\u83cc\u6297\u4f53\u6ef4\u5ea6\u3001\u80ba\u529f\u80fd\u53c2\u6570\u548c\u4f53\u5916\u9f3b\u776b\u72b6\u4f53\u529f\u80fd\u8bc4\u4f30\u6548\u679c\u3002\u867d\u7136\u6574\u4f53\u80ba\u529f\u80fd\u6216\u4e34\u5e8a\u8bc4\u5206\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u4f46\u4ee5PEFR\u5b9a\u4e49\u4e3a\u4f4e\u4e8e\u9884\u6d4b\u503c70%\u7684\u8f83\u91cdCF\u60a3\u8005\uff0c\u5728NAC\u6cbb\u7597\u671f\u95f4PEFR\u3001FVC\u548cFEV<sub>1<\/sub>\u5747\u6709\u663e\u8457\u6539\u5584\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">74<\/a><\/p>\n<p class=\"wp-block-paragraph\">Ratjen\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b75-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u5e73\u884c\u7ec4\u3001\u968f\u673a\u3001\u53cc\u76f2\u7814\u7a76\uff0c\u6bd4\u8f83\u53e3\u670dNAC\uff08\u6bcf\u65e5\u4e09\u6b21\uff0c200\u6beb\u514b\uff09\u3001\u5b89\u5e03\u7f57\u7d22\uff08\u6bcf\u65e5\u4e09\u6b21\uff0c\u6bcf\u6b2130\u6beb\u514b\uff09\u548c\u5b89\u6170\u5242\uff0c\u5bf9\u8c61\u4e3a36\u540d\u56ca\u6027\u7ea4\u7ef4\u5316\u513f\u7ae5\uff08\u5e73\u5747\u5e74\u9f8413.9\u5c81\uff09\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u5728\u4e09\u4e2a\u6708\u671f\u95f4\uff0c\u901a\u8fc7\u4f53\u4f53\u6c14\u8c61\u63cf\u8bb0\u6cd5\u3001\u56f0\u6c14\u6d4b\u5b9a\u548c\u6700\u5927\u547c\u6c14\u6d41\u91cf-\u4f53\u79ef\u66f2\u7ebf\u8bc4\u4f30\u80ba\u529f\u80fd\u3002\u867d\u7136\u4e24\u7ec4\u4e4b\u95f4\u672a\u53d1\u73b0\u663e\u8457\u5dee\u5f02\uff0c\u4f46\u5b89\u6170\u5242\u7ec4\u663e\u793a\u80ba\u529f\u80fd\u53d7\u635f\u8f83\u5927\uff0c\u6697\u793aNAC\u6216\u5b89\u5e03\u7f57\u7d22\u53ef\u80fd\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b75-dic-2025-7-7\">75<\/a><\/p>\n<p class=\"wp-block-paragraph\">Gotz\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b76-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u4ea4\u53c9\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\uff0c\u8bc4\u4f30\u53e3\u670dNAC\uff089.5 mg\/kg\uff09\u572821\u540d\u60a3\u6709\u56ca\u6027\u7ea4\u7ef4\u5316\uff08CF\uff09\u60a3\u800514\u5929\u5185\u7684\u6548\u679c\u3002\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86\u75f0\u6db2\u751f\u6210\u3001\u54b3\u55fd\u548c\u80ba\u529f\u80fd\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u6cbb\u7597\u548c\u5b89\u6170\u5242\u671f\u95f4\u5747\u663e\u793a\u6574\u4f53\u6539\u5584\uff0c\u4f46NAC\u7684\u6cbb\u7597\u6548\u679c\u672a\u4f5c\u660e\u786e\u533a\u5206\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b76-dic-2025-7-7\">76<\/a><\/p>\n<p class=\"wp-block-paragraph\">Baran\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b77-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u4ea4\u53c9\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\uff0c\u9488\u5bf9\u516d\u540d\u56ca\u6027\u7ea4\u7ef4\u5316\u513f\u7ae5\u8fdb\u884c\u6bd4\u8f83\uff0c\u53e3\u670dNAC\uff0819.4 mg\/kg\uff09\u4e0e\u5b89\u6170\u5242\u7ec4\u572815\u5929\u5185\u8fdb\u884c\u6bd4\u8f83\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u867d\u7136\u5b89\u6170\u5242\u6cbb\u7597\u671f\u95f4\u4e3b\u89c2\u75c7\u72b6\u548c\u80f8\u90e8\u8868\u73b0\u52a0\u91cd\uff0cNAC\u5219\u6539\u5584\u4e86FEV<sub>1<\/sub>\u3001PEFR\u548c\u6700\u5927\u547c\u6c14\u6d41\u91cf\u3002<\/p>\n<h3 class=\"wp-block-heading\">\u975e\u968f\u673a\u5bf9\u7167\u7814\u7a76<\/h3>\n<p class=\"wp-block-paragraph\">Rudnik\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b78-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u5f00\u653e\u3001\u5bf9\u7167\u7814\u7a76\uff0c\u8bc4\u4f30\u53e3\u670dNAC\u5728\u6162\u6027\u80ba\u75c5\u513f\u7ae5\u4e2d\u7684\u7597\u6548\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u8be5\u7814\u7a76\u6d89\u53ca\u4e09\u4e2a\u961f\u5217\u4e2d\u768458\u540d\u513f\u7ae5\uff0c\u4e3b\u8981\u7ec4\u4e3a46\u540d\u5e74\u9f84\u57282\u4e2a\u6708\u81f316\u5c81\u4e4b\u95f4\u7684\u513f\u7ae5\uff0c\u5176\u4e2d\u8d85\u8fc7\u4e00\u534a\u5e74\u9f84\u57285\u5c81\u4ee5\u4e0b\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b78-dic-2025-7-7\">78<\/a>&nbsp;NAC\u7684\u5242\u91cf\u4ece\u6bcf\u5929\u4e24\u6b2150\u6beb\u514b\u5230\u6bcf\u65e5\u4e09\u6b21200\u6beb\u514b\u4e0d\u7b49\uff0c\u6309\u5e74\u9f84\u8c03\u6574\uff0c\u6301\u7eed4\u5468\u3002\u7597\u6548\u901a\u8fc7\u4e34\u5e8a\u8bc4\u4f30\u3001\u80ba\u90e8\u542c\u8bca\u3001\u80f8\u90e8X\u5149\u3001\u8840\u6c14\u5206\u6790\u53ca\u6cbb\u7597\u524d\u540e\u652f\u6c14\u7ba1\u955c\u68c0\u67e5\u8fdb\u884c\u8bc4\u4f30\u3002\u7b2c\u4e00\u7ec4\u4e2d\uff0c46\u540d\u513f\u7ae5\u4e2d\u670941\u4eba\u4e34\u5e8a\u8868\u73b0\u6709\u6240\u6539\u5584\u300217\u540d\u513f\u7ae5\u75c7\u72b6\u5b8c\u5168\u6d88\u5931\uff0c\u5305\u62ec\u542c\u89c9\u53d8\u5316\u548c\u5598\u606f\u6d88\u5931\uff0c24\u540d\u513f\u7ae5\u8868\u73b0\u51fa\u4e2d\u5ea6\u6539\u5584\u3002\u80f8\u90e8X\u5149\u786e\u8ba415\u540d\u513f\u7ae5\u7684\u653e\u5c04\u5b66\u6539\u5584\uff0c\u652f\u6c14\u7ba1\u5468\u56f4\u5145\u8840\u548c\u5468\u56f4\u80ba\u6c14\u80bf\u6709\u6240\u51cf\u8f7b\u30027\u540d\u513f\u7ae5\u5728\u6240\u6709\u8bc4\u4f30\u53c2\u6570\u4e0a\u5747\u6709\u6539\u5584;\u4f46\u6709\u4e94\u540d\u513f\u7ae5\u5728\u63a5\u53d7NAC\u6cbb\u7597\u540e\u65e0\u6539\u5584\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b78-dic-2025-7-7\">78<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u7b2c\u4e8c\u7ec4\u516d\u540d\u513f\u7ae5\u7684\u80ba\u529f\u80fd\u6d4b\u8bd5\u672a\u663e\u793a\u6cbb\u7597\u524d\u540e\u663e\u8457\u5dee\u5f02\u3002\u7136\u800c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b78-dic-2025-7-7\"><\/a>\uff0c\u4e0e\u4e24\u4e2a\u5bf9\u7167\u7ec4\u2014\u2014\u4e00\u7ec4\u63a5\u53d7Mesna\u5438\u5165\u6cbb\u7597\u7684\u513f\u7ae5\u548c\u53e6\u4e00\u7ec4\u63a5\u53d70.45%\u751f\u7406\u76d0\u6c34\u5438\u5165\u6cbb\u7597\u7684\u513f\u7ae5\u76f8\u6bd4\uff0cNAC\u6cbb\u7597\u513f\u7ae5\u5728\u5c0f\u6c14\u9053\u529f\u80fd\u548c\u6c14\u9053\u963b\u529b\u65b9\u9762\u8868\u73b0\u51fa\u7565\u6709\u6539\u5584\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u5dee\u5f02\u5728\u7edf\u8ba1\u5b66\u4e0a\u5e76\u4e0d\u663e\u8457\u3002\u540c\u6837\uff0c\u533a\u57df\u80ba\u529f\u80fd\u5206\u6790\u663e\u793a\u6cbb\u7597\u540e\u65e0\u663e\u8457\u53d8\u5316\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b78-dic-2025-7-7\">78<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u7b2c\u4e09\u6279\u540c\u6837\u5305\u62ec\u516d\u540d\u513f\u7ae5\uff0c\u63a5\u53d7\u4e86\u652f\u6c14\u7ba1\u5206\u6ccc\u7269\u4e2d\u86cb\u767d\u8d28\u6c34\u5e73\u7684\u751f\u5316\u8bc4\u4f30\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b78-dic-2025-7-7\">78<\/a>&nbsp;\u7ed3\u679c\u663e\u793a\uff0cNAC\u5904\u7406\u540e\u652f\u6c14\u7ba1\u5206\u6cccIgA\u548c\u03b11\u6297\u6297\u7cd6\u86cb\u767d\u9176\u6c34\u5e73\u663e\u8457\u4e0b\u964d\uff0c\u8840\u6e05IgA\u3001IgG\u548c\u03b11\u6297\u80f0\u86cb\u767d\u9176\u6c34\u5e73\u4e5f\u76f8\u5e94\u4e0a\u5347\u3002\u76d1\u6d4b\u7c98\u819c\u708e\u75c7\u7684\u68c0\u67e5\u663e\u793a\uff0c\u63a5\u53d7\u5438\u5165\u7597\u6cd5\uff08\u5982\u7c73\u65af\u5854\u5e03\u9686\u6216\u6c22\u5316\u53ef\u7684\u677e\uff09\u7684\u513f\u7ae5\u6cbb\u7597\u6548\u679c\u4f18\u4e8eNAC\u7ec4\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b78-dic-2025-7-7\">78<\/a><\/p>\n<p class=\"wp-block-paragraph\">Steil\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b79-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u4ea4\u53c9\u5f00\u653e\u6807\u7b7e\u7814\u7a76\uff0c\u6bd4\u8f83\u53e3\u670dNAC\u548c\u78b3\u534a\u80f1\u6c28\u9178\u572822\u540d\u56ca\u6027\u7ea4\u7ef4\u5316\u513f\u7ae5\u4e2d\u7684\u7597\u6548\u3002NAC\u7684\u5242\u91cf\u4ece10\u81f330 mg\/kg\u523020\u540d\u60a3\u8005\u4e4b\u95f4\uff0c\u5176\u4f59\u60a3\u8005\u5219\u670d\u7528\u78b3\u534a\u80f1\u6c28\u9178\uff08500\u2013750 mg\/\u5929\uff09\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u57283\u52306\u4e2a\u6708\u4e4b\u95f4\u3002\u5728\u57fa\u7840FVC\u4f4e\u4e8e75%\u7684\u60a3\u8005\u4e2d\uff0cNAC\u663e\u8457\u6539\u5584\u4e86\u80ba\u529f\u80fd\u3002\u5177\u4f53\u6765\u8bf4\uff0c12\u4f8b\u60a3\u8005\u5728NAC\u6cbb\u7597\u540e\u5e73\u5747FVC\u4ece59.5%\u4e0a\u5347\u81f375.5%\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b79-dic-2025-7-7\">79<\/a><\/p>\n<p class=\"wp-block-paragraph\">Baldini\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b80-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u4e3b\u52a8\u5bf9\u7167\u7814\u7a76\uff0c\u6bd4\u8f83\u4e8628\u540d2\u81f313\u5c81\uff08\u5e73\u57477\u5c813\u4e2a\u6708\uff09\u88ab\u8bca\u65ad\u4e3a\u75c9\u631b\u6027\u652f\u6c14\u7ba1\u708e\u7684\u513f\u7ae5\u4e2d\u5b89\u5e03\u7f57\u7d22\u5c14\u548cNAC\u7684\u7597\u6548\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b80-dic-2025-7-7\">80<\/a>\u540d\u60a3\u8005\u63a5\u53d7\u5b89\u5e03\u7f57\u7d22\uff0830\u6beb\u514b\/\u5929\uff09\uff0c\u5176\u4f5914\u4eba\u63a5\u53d7NAC\uff08200\u2013300\u6beb\u514b\/\u5929\uff09\u6cbb\u7597\u3002\u8be5\u6cbb\u7597\u53e3\u670d\u7ed9\u836f\uff0c\u6301\u7eed10\u5929\u3002\u7597\u6548\u8bc4\u4f30\u5305\u62ec\u57fa\u7840\u3001\u7b2c5\u5929\u53ca\u6cbb\u7597\u7ed3\u675f\u65f6\u7684\u75f0\u91cf\u548c\u7c98\u5ea6\u3001\u5410\u75f0\u96be\u5ea6\u3001\u54b3\u55fd\u4e25\u91cd\u7a0b\u5ea6\u3001\u547c\u5438\u56f0\u96be\u548c\u652f\u6c14\u7ba1\u97f3\u3002\u8fd9\u4e24\u79cd\u6cbb\u7597\u90fd\u5e26\u6765\u4e86\u4e34\u5e8a\u4e0a\u7684\u6539\u5584;\u7136\u800c\uff0c\u5b89\u5e03\u7f57\u7d22\u5c14\u7684\u8d77\u6548\u66f4\u5feb\uff0c\u60a3\u8005\u75c7\u72b6\u7f13\u89e3\u5f97\u6bd4\u63a5\u53d7NAC\u7684\u60a3\u8005\u66f4\u65e9\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b80-dic-2025-7-7\">80<\/a><\/p>\n<p class=\"wp-block-paragraph\">Dietzsch\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b81-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u6bd4\u8f83\u7814\u7a76\uff0c\u8bc4\u4f30\u4e8624\u540d2\u81f312\u5c81\u56ca\u6027\u7ea4\u7ef4\u5316\u513f\u7ae5\u5438\u5165NAC\u4e0eL-\u7cbe\u6c28\u9178\u76d0<em><\/em>\u9178\u6c14\u6eb6\u80f6\u7684\u9ecf\u6db2\u6eb6\u89e3\u6548\u5e94\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t1-dic-2025-7-7\">\u89c1\u88681<\/a>\uff09\u3002\u4e34\u5e8a\u8bc4\u4f30\u5305\u62ec\u652f\u6c14\u7ba1\u955c\u3001\u6c14\u6ce1\u56fe\u3001\u95ea\u70c1\u56fe\u548c\u5316\u5b66\u5206\u6790\uff0c\u4ee5\u786e\u5b9a\u6bcf\u79cd\u6cbb\u7597\u7684\u7597\u6548\u3002NAC\u5438\u5165\u663e\u793a\u51fa\u4f18\u4e8eL-\u7cbe\u6c28\u9178\u76d0\u9178\u76d0\u7684\u9ecf\u6db2\u6eb6\u89e3\u6548\u679c\u3002\u54b3\u55fd\u5929\u6570\u4ece\u7b2c\u4e00\u6b21\u5438\u5165NAC\u671f\u95f4\u76842.9%\u4e0a\u5347\u5230L-\u7cbe\u6c28\u9178\u76d0\u9178\u76d0\u5438\u5165\u671f\u768423.1%\uff0c\u968f\u540e\u5728\u7b2c\u4e8c\u6b21\u5438\u5165NAC\u671f\u95f4\u964d\u81f39.8%\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b81-dic-2025-7-7\">81<\/a><\/p>\n<h3 class=\"wp-block-heading\">\u975e\u5bf9\u7167\u6216\u56de\u987e\u6027\u4e34\u5e8a\u7814\u7a76<\/h3>\n<p class=\"wp-block-paragraph\">Ribeiro\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b82-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u5f00\u653e\u3001\u975e\u5bf9\u7167\u7814\u7a76\uff0c\u8bc4\u4f30\u53e3\u670dNAC\u572880\u540d\u60a3\u6709\u591a\u79cd\u6162\u6027\u80ba\u90e8\u75be\u75c5\u7684\u513f\u79d1\u60a3\u8005\u4e2d\u7684\u7597\u6548\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t2-dic-2025-7-7\">\u89c1\u88682<\/a>\uff09\u3002\u60a3\u8005\u5e74\u9f84\u4ece23\u5929\u523011\u5c81\uff08\u5e73\u57472.9\u5c81\uff09\u4e0d\u7b49\uff0c\u5176\u4e2d33\u540d\u513f\u7ae5\u672a\u6ee11\u5c81\uff0c34\u540d1\u81f36\u5c81\uff0c13\u540d6\u81f311\u5c81\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b82-dic-2025-7-7\">82<\/a>&nbsp;\u8bca\u65ad\u5305\u62ec\u652f\u6c14\u7ba1\u6269\u5f20\uff08<em>n<\/em>=8\uff09\u3001\u652f\u6c14\u7ba1\u75c5\u53d8\uff08<em>n<\/em>=4\uff09\u3001\u5047\u6027\u652f\u6c14\u7ba1\u6269\u5f20\uff08<em>n<\/em>=6\uff09\u3001\u56ca\u6027\u7ea4\u7ef4\u5316\uff08<em>n<\/em>=2\uff09\u3001\u80ba\u4e0d\u5f20\uff08<em>n<\/em>=15\uff09\u3001\u6162\u6027\u652f\u6c14\u7ba1\u708e\uff08<em>n<\/em>=1\uff09\u3001\u80ba\u8113\u80bf\uff08<em>n<\/em>=1\uff09\u53ca\u6df7\u5408\u75c5\u53d8\uff08<em>n<\/em>=30\uff09\u3002NAC\u53e3\u670d\u5242\u91cf\u4e3a10\u201350 mg\/kg\/\u5929\uff0c\u6301\u7eed\u65f6\u95f4\u4e3a7\u81f3110\u5929\uff08\u5e73\u5747\u6301\u7eed\u65f6\u95f4\uff1a26.7\u5929\uff09\uff0c\u6b64\u524d\u6297\u751f\u7d20\u3001\u76ae\u8d28\u7c7b\u56fa\u9187\u548c\u652f\u6c14\u7ba1\u6269\u5f20\u5242\u7b49\u5176\u4ed6\u6cbb\u7597\u5747\u544a\u5931\u8d25\u3002\u4e34\u5e8a\u548c\u653e\u5c04\u5b66\u7ed3\u5c40\u88ab\u5206\u4e3a\u4f18\u79c0\u3001\u826f\u597d\u6216\u52a3\u7b49\uff0c\u6cbb\u7597\u63a5\u53d7\u5ea6\u548c\u5b89\u5168\u6027\u5219\u5206\u4e3a\u826f\u597d\u3001\u4e2d\u7b49\u6216\u52a3\u7b49\u3002\u572867\u540d\u5b8c\u6210\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c88%\u548c82%\u5206\u522b\u8868\u73b0\u51fa\u826f\u597d\u7684\u4e34\u5e8a\u548c\u653e\u5c04\u5b66\u7ed3\u5c40\uff0c\u5305\u62ec\u652f\u6c14\u7ba1\u5468\u56f4\u5145\u8840\u548c\u5468\u56f4\u80ba\u6c14\u80bf\u7684\u7f13\u89e3\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b82-dic-2025-7-7\">82<\/a><\/p>\n<p class=\"wp-block-paragraph\">Szekely\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b83-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u5f00\u653e\u7684\u975e\u5bf9\u7167\u7814\u7a76\uff0c\u5bf9\u8c61\u4e3a20\u540d6\u81f312\u5c81\u7684\u6162\u6027\u652f\u6c14\u7ba1\u708e\u513f\u7ae5\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t2-dic-2025-7-7\">\u89c1\u88682<\/a>\uff09\u3002\u53c2\u4e0e\u8005\u63a5\u53d7\u53e3\u670dNAC\uff08\u6bcf\u65e5\u4e09\u6b21\uff0c\u6bcf\u6b21100\u6beb\u514b\uff0937\u5929\u3002\u5728\u7b2c7\u5929\u53ca\u6cbb\u7597\u7ed3\u675f\u65f6\u8fdb\u884c\u4e86\u652f\u6c14\u7ba1\u955c\u68c0\u67e5\uff0c\u4ee5\u8bc4\u4f30\u9ecf\u819c\u708e\u75c7\u548c\u5206\u6ccc\u8fc7\u591a\u7684\u60c5\u51b5\u3002NAC\u4f7f10\u540d\u60a3\u8005\u9ecf\u819c\u708e\u75c7\u9000\u5316\uff0c18\u540d\u60a3\u8005\u5b8c\u5168\u505c\u6b62\u8fc7\u5ea6\u5206\u6ccc\uff0c2\u540d\u60a3\u8005\u51cf\u5c11\u8fc7\u5ea6\u5206\u6ccc\u3002\u7ec4\u7ec7\u5b66\u68c0\u67e5\u672a\u53d1\u73b0\u9ecf\u819c\u7ed3\u6784\u6709\u663e\u8457\u53d8\u5316\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b83-dic-2025-7-7\">83<\/a><\/p>\n<p class=\"wp-block-paragraph\">Nikolic\u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b84-dic-2025-7-7\">84<\/a>\u8c03\u67e5\u4e86\u53e3\u670dNAC\u572820\u540d3\u81f314\u5c81\u53cd\u590d\u53d1\u70ed\u652f\u6c14\u7ba1\u708e\u513f\u7ae5\u4e2d\u7684\u4f5c\u7528\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t2-dic-2025-7-7\">\u89c1\u88682<\/a>\uff09\u3002\u6025\u6027\u652f\u6c14\u7ba1\u708e\u53d1\u4f5c\u671f\u95f4\uff0cNAC\uff08\u6bcf\u65e5\u4e09\u6b21\uff0c\u6bcf\u6b21100\u2013200\u6beb\u514b\uff09\u4e0e\u6297\u751f\u7d20\u540c\u65f6\u670d\u7528\uff0c\u6301\u7eed4\u5929\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b84-dic-2025-7-7\">84<\/a>&nbsp;\u4e34\u5e8a\u76d1\u6d4b\u6bcf\u65e5\u6216\u9694\u5929\u8fdb\u884c\u3002NAC\u7f29\u77ed\u4e86\u5589\u5499\u3001\u5361\u4ed6\u548c\u652f\u6c14\u7ba1\u708e\u75c7\u72b6\u7684\u6301\u7eed\u65f6\u95f4\u3002\u7b80\u5355\u6216\u590d\u53d1\u6027\u8f6f\u7ba1\u708e\u513f\u7ae5\u7684\u751f\u547d\u529b\u548c\u80ba\u6d41\u91cf\u6062\u590d\u6b63\u5e38\uff0c\u4f46\u652f\u6c14\u7ba1\u8fc7\u654f\u60a3\u8005\u672a\u89c1\u53d8\u5316\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b84-dic-2025-7-7\">84<\/a><\/p>\n<p class=\"wp-block-paragraph\">Dietzsch\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b85-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u5f00\u653e\u3001\u975e\u5bf9\u7167\u7814\u7a76\uff0c\u9488\u5bf942\u540d\u56ca\u6027\u7ea4\u7ef4\u5316\u513f\u7ae5\uff0c\u8fd9\u4e9b\u513f\u7ae5\u5728\u63a5\u53d7NAC\u5438\u5165\u6cbb\u7597\u540e\u7a33\u5b9a\u4e868\u201310\u5e74\uff0c\u4e4b\u540e\u8f6c\u4e3a\u53e3\u670dNAC\u6cbb\u75976\u4e2a\u6708\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t2-dic-2025-7-7\">\u89c1\u88682<\/a>\uff09\u30028\u5c81\u4ee5\u4e0b\u513f\u7ae5\u6bcf\u5929\u4e09\u6b21\uff0c\u6bcf\u6b21100\u6beb\u514bNAC\uff0c8\u5c81\u4ee5\u4e0a\u513f\u7ae5\u6bcf\u5929\u4e09\u6b21\uff0c\u6bcf\u6b21200\u6beb\u514b\u3002\u7597\u6548\u901a\u8fc7\u652f\u6c14\u7ba1\u955c\u68c0\u67e5\u548c\u53e3\u670d\u6cbb\u7597\u524d\u540e\u80ba\u529f\u80fd\u6d4b\u8bd5\u8bc4\u4f30\u3002\u53e3\u670dNAC\u6cbb\u7597\u5bfc\u81f444%\u60a3\u8005\u7684\u652f\u6c14\u7ba1\u955c\u75c7\u72b6\u6076\u5316\uff0c22%\u60a3\u8005\u65e0\u53d8\u5316\uff0c34%\u60a3\u8005\u6539\u5584\u3002\u80ba\u529f\u80fd\u6539\u5584\u7387\u4e3a18%\uff0c51%\u4fdd\u6301\u4e0d\u53d8\uff0c31%\u75c5\u4f8b\u6076\u5316\u3002\u603b\u4f53\u6765\u770b\uff0c56%\u7684\u60a3\u8005\u5728\u652f\u6c14\u7ba1\u955c\u68c0\u67e5\u4e2d\u8868\u73b0\u51fa\u6539\u5584\u6216\u4fdd\u6301\u7a33\u5b9a\uff0c69%\u57fa\u4e8e\u80ba\u529f\u80fd\u6d4b\u8bd5\u30027\u540d\u513f\u7ae5\u56e0\u75c5\u60c5\u52a0\u91cd\u505c\u6b62\u53e3\u670dNAC\u5e76\u6062\u590d\u5438\u5165\u6cbb\u7597\u3002\u7814\u7a76\u7ed3\u8bba\u662f\uff0c\u867d\u7136\u53e3\u670dNAC\u65e0\u6cd5\u5b8c\u5168\u66ff\u4ee3\u5438\u5165\u6cbb\u7597\uff0c\u4f46\u5bf950\u201360%\u7684\u60a3\u8005\u6709\u6548\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b85-dic-2025-7-7\">85<\/a><\/p>\n<p class=\"wp-block-paragraph\">Stephan\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b86-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u591a\u4e2d\u5fc3\u3001\u975e\u5bf9\u7167\u7814\u7a76\uff0c\u8bc4\u4f3063\u540d2\u81f320\u5c81\u56ca\u6027\u7ea4\u7ef4\u5316\u60a3\u8005\u53e3\u670d<em>\u4e0e<\/em>\u5438\u5165NAC\u7684\u6548\u679c\uff0c\u5386\u65f62\u5e74\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t2-dic-2025-7-7\">\u89c1\u88682<\/a>\uff09\u3002\u5165\u7ec4\u524d\uff0c\u6240\u6709\u60a3\u8005\u5747\u63a5\u53d7\u4e86\u81f3\u5c11\u4e00\u5e74\u7684Mesna\u6216NAC\u5438\u5165\u6cbb\u7597\u3002\u53e3\u670dNAC\u5242\u91cf\u4e3a2\u5c81\u4ee5\u4e0b\u513f\u7ae5\u6bcf\u65e5\u4e09\u6b2150\u6beb\u514b\uff0c2\u5c81\u53ca\u4ee5\u4e0a\u513f\u7ae5\u6bcf\u65e5\u4e09\u6b21200\u6beb\u514b\u3002\u8be5\u7814\u7a76\u6301\u7eed\u4e86\u4e24\u5e74\u3002\u53e3\u670dNAC\u5728\u6539\u5584\u75f0\u6db2\u6e05\u9664\u7387\u3001\u80f8\u90e8X\u5149\u8868\u73b0\u548c\u751f\u957f\u53c2\u6570\uff08\u4f53\u91cd\u548c\u8eab\u9ad8\u767e\u5206\u4f4d\u6570\uff09\u65b9\u9762\u81f3\u5c11\u4e0e\u5438\u5165NAC\u76f8\u5f53\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b86-dic-2025-7-7\">86<\/a><\/p>\n<p class=\"wp-block-paragraph\">Reas\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b87-dic-2025-7-7\">\u4eba\u8bc4\u4f30\u4e86<\/a>\u96fe\u5316NAC\u572828\u540d7\u81f322\u5c81\u56ca\u6027\u7ea4\u7ef4\u5316\u60a3\u8005\u7684\u7597\u6548\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t2-dic-2025-7-7\">\u89c1\u88682<\/a>\uff09\u3002\u60a3\u8005\u901a\u8fc7\u6c14\u6eb6\u80f6\u5438\u5165\u6bcf\u65e5\u4e24\u6b21\uff0c\u670d\u75285\u6beb\u534720% 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href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b88-dic-2025-7-7\">\u4eba\u62a5\u544a\u4e86<\/a>\u4e24\u4f8b\u53cd\u590d\u51fa\u73b0\u7684\u53ef\u5851\u6027\u652f\u6c14\u7ba1\u708e\u513f\u79d1\u60a3\u8005\u75c5\u4f8b\u7cfb\u5217\uff0c\u8fd9\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u75be\u75c5\uff0c\u7279\u5f81\u4e3a\u963b\u585e\u6027\u652f\u6c14\u7ba1\u5185\u77f3\u818f\u7684\u5f62\u6210\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t3-dic-2025-7-7\">\u88683<\/a>\uff09\u3002\u4e00\u540d1\u5c81\u5973\u5b69\u548c\u4e00\u540d7\u5c81\u7537\u5b69\u53cd\u590d\u51fa\u73b0\u547c\u5438\u7a98\u8feb\uff0c\u652f\u6c14\u7ba1\u955c\u68c0\u67e5\u663e\u793a\u6709\u819c\u72b6\u77f3\u818f\u3002\u5e74\u8f7b\u60a3\u8005\u672f\u540e\u63a5\u53d7\u5438\u5165\u652f\u6c14\u7ba1\u6269\u5f20\u5242\u3001\u96fe\u5316NAC\uff081.5\u6beb\u5347\uff0c20%\u6eb6\u6db2\uff0c\u6bcf\u65e5\u4e24\u6b21\uff09\u3001\u80f8\u90e8\u7269\u7406\u6cbb\u7597\u53ca\u5168\u8eab\u7c7b\u56fa\u9187\u6cbb\u7597\uff0c\u6301\u7eed5\u5929\u3002\u75c5\u60c5\u6539\u5584\u540e\uff0c\u5979\u88ab\u6309\u9700\u5438\u5165\u6c99\u4e01\u80fa\u9187\u3001\u96fe\u5316NAC\u548c\u5438\u5165\u5e03\u5730\u5948\u5fb7\uff08\u6bcf\u5929\u4e24\u6b21\uff0c\u6bcf\u6b21100\u5fae\u514b\uff09\u7ef4\u6301\u6cbb\u7597\u65b9\u6848\u51fa\u9662\u300212\u4e2a\u6708\u968f\u8bbf\u65f6\u5979\u4fdd\u6301\u65e0\u75c7\u72b6\u3002\u5e74\u957f\u513f\u7ae5\u63a5\u53d7\u5438\u5165\u652f\u6c14\u7ba1\u6269\u5f20\u5242\u3001\u5e03\u5730\u5948\u5fb7\uff08400\u5fae\u514b\uff09\u957f\u6548\u03b2-\u6fc0\u52a8\u5242\u548c\u96fe\u5316NAC\uff082.5\u6beb\u5347\uff0c20%\u6eb6\u6db2\uff0c\u6bcf\u65e5\u4e24\u6b21\uff09\u3002\u57289\u4e2a\u6708\u968f\u8bbf\u671f\u95f4\uff0c\u4f7f\u7528\u7ef4\u6301\u5e03\u5730\u5948\u5fb7\uff08200\u5fae\u514b\uff09\u548c\u96fe\u5316NAC\u540e\uff0c\u547c\u5438\u9053\u75c7\u72b6\u663e\u8457\u6539\u5584\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b88-dic-2025-7-7\">88<\/a><\/p>\n<p class=\"wp-block-paragraph\">Wang\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b89-dic-2025-7-7\">\u4eba\u8fdb\u884c\u4e86\u4e00\u9879<\/a>\u56de\u987e\u6027\u961f\u5217\u7814\u7a76\uff0c\u8bc4\u4f30BAL\u4e0e\u8f85\u52a9\u836f\u7269\u572882\u540d\u96be\u6cbb\u6027\u80ba\u708e<em>\u652f\u539f<\/em>\u4f53\u80ba\u708e\u60a3\u8005\u7684\u7597\u6548\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#t3-dic-2025-7-7\">\u89c1\u88683<\/a>\uff09\u3002\u6240\u6709\u60a3\u8005\u5747\u63a5\u53d7\u6807\u51c6\u6cbb\u7597\uff0c\u5305\u62ec\u9759\u8109\u6ce8\u5c04\u963f\u5947\u9709\u7d20\u3001\u5410\u75f0\u6cbb\u7597\u548c\u96fe\u5316\u5438\u5165\u3002\u57fa\u4e8eBAL\u671f\u95f4\u7684\u8f85\u52a9\u6cbb\u7597\uff0c\u4ed6\u4eec\u88ab\u5206\u4e3a\u4e09\u7ec4\uff1a\u5355\u7528\u5e03\u5730\u6c27\u9178\u3001\u5b89\u5e03\u7f57\u7d22\u5c14+\u5e03\u5730\u6c27\u9178\u548c\u4e59\u9170\u534a\u80f1\u6c28\u9178+\u5e03\u5730\u6c27\u9178\u3002\u4e3b\u8981\u7ec8\u70b9\u5305\u62ec\u5b9e\u9a8c\u5ba4\u53c2\u6570\u7684\u53d8\u5316\u3001\u80ba\u90e8\u5f71\u50cf\u7684\u6539\u5584\u3001\u6574\u4f53\u4e34\u5e8a\u7597\u6548\u548c\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u3002\u4e09\u7ec4\u5b9e\u9a8c\u5ba4\u6307\u6807\u8f83\u57fa\u7ebf\u663e\u8457\u6539\u5584\uff0c\u6cbb\u7597\u540e\u767d\u7ec6\u80de\u8ba1\u6570\u3001CRP\u6216\u7ea2\u7ec6\u80de\u6c89\u964d\u7387\u5747\u65e0\u663e\u8457\u5dee\u5f02\u3002\u4e09\u7ec4\u8840\u6e05\u4e73\u9178\u8131\u6c22\u9176\u548c\u8840\u6e05\u94c1\u86cb\u767d\u6c34\u5e73\u663e\u8457\u5dee\u5f02\uff08<em>p<\/em>&lt;0.001\uff09\uff0c\u4e59\u9170\u534a\u80f1\u6c28\u9178+\u5e03\u5730\u5948\u5fb7\u7ec4\u5219\u663e\u8457\u8f83\u4f4e\uff08<em>p<\/em>&lt;0.001\uff09\u3002\u80ba\u75c5\u7076\u5f71\u50cf\u663e\u793a\u4e59\u9170\u534a\u80f1\u6c28\u9178+\u5e03\u5730\u5948\u5fb7\u7ec4\u7684\u5438\u6536\u7387\u66f4\u4f73\uff0c\u6574\u4f53\u4e34\u5e8a\u7597\u6548\u9ad8\u4e8e\u5176\u4ed6\u7ec4\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b89-dic-2025-7-7\">89<\/a><\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>NAC\u5728\u513f\u79d1\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u5b89\u5168\u6027\u6982\u51b5<\/h2>\n<p class=\"wp-block-paragraph\">\u5728\u672c\u7efc\u8ff0\u7eb3\u5165\u7684\u5927\u591a\u6570\u7814\u7a76\u4e2d\uff0c\u53e3\u670d\u548c\u5438\u5165NAC\u5747\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u62a5\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\u6216\u4e0d\u826f\u4e8b\u4ef6\u6781\u5c11\u3002\u591a\u9879\u7814\u7a76\u4e00\u81f4\u89c2\u5bdf\u5230\u8fd9\u79cd\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4f4e\u300219,21,63\u2013<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b19-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b63-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b21-dic-2025-7-7\"><\/a>66,72,75,76,79,80,83,85,90 \u5728\u5176\u4ed6\u7814\u7a76\u4e2d\uff0cNAC\u6cbb\u7597\u7ec4\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4e0e\u5bf9\u7167\u7ec4\u76f8\u5f53\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b85-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b79-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b90-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b83-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b80-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b72-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b66-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b75-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b67-dic-2025-7-7\">67,68,89\uff0cBaran<\/a>\u7b49\u4eba\u7684\u7814\u7a76\u9664\u5916\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b68-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b77-dic-2025-7-7\">77<\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b76-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b89-dic-2025-7-7\"><\/a>\u8bb0\u5f55\u4e86\u80c3\u80a0\u9053\u4e0d\u9002\u3002\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u4e8b\u4ef6\u5e76\u672a\u4e25\u91cd\u5230\u9700\u8981\u505c\u6b62\u6cbb\u7597\u3002\u6b64\u5916\uff0cLiu\u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b71-dic-2025-7-7\">71<\/a>\u89c2\u5bdf\u5230NAC\u7ec4\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u663e\u8457\u4f4e\u4e8e\u5bf9\u7167\u7ec4\uff0c\u8fdb\u4e00\u6b65\u652f\u6301\u8be5\u836f\u7269\u7684\u826f\u597d\u5b89\u5168\u6027\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u5c3d\u7ba1NAC\u6574\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u4f46\u4e5f\u6709\u5c11\u6570\u4e0d\u826f\u53cd\u5e94\u5bfc\u81f4\u6cbb\u7597\u4e2d\u6b62\u7684\u60c5\u51b5\u3002\u4f8b\u5982\uff0c\u5728\u4e24\u9879\u7814\u7a76\u4e2d\uff0c\u5c11\u6570\u60a3\u8005\u51fa\u73b0\u4e25\u91cd\u5230\u9700\u8981\u505c\u836f\u7684\u4e0d\u826f\u53cd\u5e94\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">\u5728<\/a>\u5176\u4e2d\u4e00\u9879\u7814\u7a76<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b82-dic-2025-7-7\"><\/a>\u4e2d\uff0c21\u540d\u60a3\u8005\u56e0\u5404\u79cd\u539f\u56e0\u88ab\u6392\u9664\uff0c\u5176\u4e2d\u5305\u62ec9\u540dNAC\u7ec4\u60a3\u8005\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">74<\/a>&nbsp;\u4e00\u540d\u60a3\u8005\u51fa\u73b0\u6606\u514b\u6c0f\u6c34\u80bf\uff0c\u53e6\u4e00\u540d\u60a3\u8005\u51fa\u73b0\u9ec4\u6cb9\u80bf\uff0c\u5747\u5728\u505c\u7528NAC\u540e\u7f13\u89e3\u3002\u53e6\u5916<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">74<\/a>\u540d\u6392\u9664\u56e0\u8179\u75db\u3001\u54b3\u55fd\u7387\u4e0b\u964d\u53ca\u54b3\u55fd\u9891\u7387\u589e\u52a0\u53ca\u914d\u5408\u4e0d\u826f\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">74<\/a>&nbsp;Baran\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b77-dic-2025-7-7\">\u4eba\u62a5\u544a\u79f0<\/a>\uff0c\u6709\u4e24\u540d\u60a3\u8005\u56e0\u4e25\u91cd\u652f\u6c14\u7ba1\u963b\u585e\u548c\u7ec6\u83cc\u6076\u5316\u5728\u836f\u7269\u6cbb\u7597\u9636\u6bb5\u9000\u51fa\u7814\u7a76\uff1a\u4e00\u4f4d\u5728\u6d17\u51c0\u671f\uff0c\u53e6\u4e00\u4f4d\u5728\u836f\u7269\u6cbb\u7597\u671f\u3002\u4e24\u9879\u7814\u7a76\u62a5\u544a\u4e86\u5438\u5165NAC\u8bf1\u53d12\u5c81\u4ee5\u4e0a\u54ee\u5598\u513f\u7ae5\u652f\u6c14\u7ba1\u6536\u7f29\u7684\u60c5\u51b5\u3002\u56e0\u6b64<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b91-dic-2025-7-7\"><\/a>\uff0c11<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b92-dic-2025-7-7\"><\/a>\u540d\u513f\u7ae5\uff0831%\uff09\u88ab\u4ece\u5176\u4e2d\u4e00\u9879\u7814\u7a76\u4e2d\u64a4\u51fa;\u4f5c\u8005\u4e3b\u8981\u5c06\u8fd9\u4e00\u526f\u4f5c\u7528\u5f52\u56e0\u4e8e\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u9ad8\u6d53\u5ea6\uff0820%\uff09\u3002\u76f8\u6bd4<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b92-dic-2025-7-7\">\u4e4b\u4e0b\uff0c<\/a>\u53e6\u4e00\u9879\u4f7f\u7528\u8f83\u4f4e\u6d53\u5ea6\uff0810%\uff09\u7684\u7814\u7a76\u5219\u672a\u62a5\u544a\u6b64\u7c7b\u6548\u5e94\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b93-dic-2025-7-7\">93<\/a><\/p>\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-vivid-red-color\">\u5c3d\u7ba1NAC\u5728\u5e74\u957f\u513f\u7ae5\u4e2d\u901a\u5e38\u8010\u53d7\u826f\u597d\uff0c\u4f46\u57282\u5c81\u4ee5\u4e0b\u7684\u5a74\u5e7c\u513f\u4e2d\u62a5\u544a\u4e86\u5b89\u5168\u9690\u60a3\uff0c\u5305\u62ec\u53cd\u5411\u6027\u652f\u6c14\u7ba1\u5145\u8840\u3001\u547c\u5438\u56f0\u96be\u52a0\u5267\u3001\u80f8\u819c\u80ba\u708e\u75c5\u4f8b\u4ee5\u53ca\u4e00\u4f8b\u81f4\u547d\u7684\u80ba\u6c34\u80bf\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b22-dic-2025-7-7\">22,23<\/a>&nbsp;\u8fd9\u4e9b\u4e8b\u4ef6\u5bfc\u81f4\u5927\u591a\u6570\u75c5\u4f8b\u4f4f\u9662\uff0c<\/mark><mark class=\"has-inline-color has-vivid-cyan-blue-color\">\u5efa\u8bae\u57282\u5c81\u4ee5\u4e0b\u60a3\u8005\u4f7f\u7528\u9ecf\u6db2\u6eb6\u89e3\u5242(\u5305\u62ecNAC)\u65f6\u5e94\u8c28\u614e\u4f7f\u7528\u3002<\/mark><mark class=\"has-inline-color has-vivid-red-color\"><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b23-dic-2025-7-7\"><\/a>\u8fd9\u4e9b\u5b89\u5168\u6027\u95ee\u9898\u4e3a\u9488\u5bf9\u5e74\u9f84\u7684\u6cbb\u7597\u8003\u8651\u63d0\u4f9b\u4e86\u91cd\u8981\u80cc\u666f\u3002<\/mark><\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>\u8ba8\u8bba<\/h2>\n<p class=\"wp-block-paragraph\">\u672c\u7efc\u8ff0\u7efc\u5408\u7ed3\u679c\u5f3a\u8c03\u4e86NAC\u5728\u513f\u79d1\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u5f3a\u8c03\u6839\u636e\u7ed9\u836f\u9014\u5f84\u3001\u60a3\u8005\u5e74\u9f84\u548c\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u8fdb\u884c\u5242\u91cf\u4f18\u5316\u7684\u91cd\u8981\u6027\u3002\u5c24\u5176\u662f\u5728\u66f4\u5e74\u5e7c\u7684\u513f\u7ae5\u4e2d\uff0c\u5242\u91cf\u65b9\u6848\u5b58\u5728\u5dee\u5f02\uff0c\u4e34\u5e8a\u5224\u65ad\u5e38\u5e38\u6307\u5bfc\u6cbb\u7597\uff0c\u51f8\u663e\u4e86\u9274\u4e8e\u513f\u79d1\u4eba\u7fa4\u72ec\u7279\u8106\u5f31\u6027\uff0c\u9700\u6301\u7eed\u52aa\u529b\u4f18\u5316\u5242\u91cf\u7b56\u7565\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u5927\u91cf\u7814\u7a76\u8868\u660e\u53e3\u670dNAC\u5728\u6cbb\u75972\u5c81\u4ee5\u4e0a\u513f\u7ae5\u6025\u6027\u548c\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u300221,61,65,66,73\u2013<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b21-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b73-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b66-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b65-dic-2025-7-7\"><\/a>76,78,79,86,94 \u5728\u6025\u6027\u73af\u5883\u4e2d\uff0c\u5982\u652f\u6c14\u7ba1\u708e\u548c\u6c14\u7ba1\u708e\uff0cFiocchi<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">\u7b49\u4eba\u62a5\u544a<\/a>\u79f0\uff0c\u5c06NAC\u7cd6\u6d46\u4ee520 mg\/kg\/\u5929\u5242\u91cf\u5206\u4e09\u6b21\u5206\u7ed9\uff0c\u663e\u8457\u6539\u5584\u547c\u5438\u75c7\u72b6\uff0c\u7279\u522b\u662f\u901a\u8fc7\u51cf\u5c11\u80f8\u8154\u6e7f\u58f0\u548c\u63d0\u9ad8\u54b3\u55fd\u6548\u7387\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b76-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b78-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b79-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b86-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b94-dic-2025-7-7\"><\/a>\u6cbb\u7597\u8868\u73b0\u51fa\u65e9\u671f\u7684\u6548\u679c\uff0c\u7b2c\u4e8c\u5468\u65f6\u5df2\u89c1\u660e\u663e\u6539\u5584\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">61<\/a>&nbsp;\u7c7b\u4f3c\u5730\uff0cBiscatti\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b21-dic-2025-7-7\">\u4eba\u91c7\u7528\u4e86<\/a>\u5e74\u9f84\u8c03\u6574\u5242\u91cf\u2014\u2014<mark class=\"has-inline-color has-vivid-cyan-blue-color\">2\u5c81\u4ee5\u4e0b\u513f\u7ae5\u6bcf\u5929100\u6beb\u514b\uff0c2\u81f34\u5c81\u513f\u7ae5\u6bcf\u5929200\u6beb\u514b\uff0c4\u5c81\u4ee5\u4e0a\u513f\u7ae5\u6bcf\u5929300\u6beb\u514b\u2014\u2014\u53d1\u73b0\u53e3\u670dNAC\u76f8\u6bd4\u5355\u72ec\u6297\u751f\u7d20\u6cbb\u7597\u80fd\u52a0\u901f\u53d1\u70e7\u548c\u80f8\u690e\u5f02\u5e38\u7684\u7f13\u89e3\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u9002\u5ea6\u53e3\u670dNAC\u5728\u7ba1\u7406\u513f\u7ae5\u6025\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u65b9\u9762\u5177\u6709\u6709\u6548\u6548\u679c\u3002<\/mark><\/p>\n<p class=\"wp-block-paragraph\">Steil\u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b79-dic-2025-7-7\">79<\/a>\u5728\u53e3\u670dNAC\u6cbb\u7597\u4e2d\u89c2\u5bdf\u5230\u547c\u5438\u6307\u6807\u6539\u5584\uff0c\u5242\u91cf\u4e3a10\u201330 mg\/kg\/\u5929\u3002\u7136\u800c\uff0c\u8be5\u7814\u7a76\u7684\u65b9\u6cd5\u8bba\u5c40\u9650\u6027\u4f7f\u5f97\u5bf9\u8fd9\u4e9b\u53d1\u73b0\u8fdb\u884c\u8c28\u614e\u89e3\u8bfb\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u63a2\u8ba8\u4e86\u5728\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u5982\u56ca\u6027\u7ea4\u7ef4\u5316\uff08CF\uff09\u6cbb\u7597\u4e2d\u4f7f\u7528\u66f4\u9ad8\u5242\u91cf\u7684\u53e3\u670dNAC\u836f\u7269\u3002Mitchell\u548cElliott<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b72-dic-2025-7-7\">72\uff0cRatjen<\/a>\u7b49\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b75-dic-2025-7-7\">75\uff0cStafanger<\/a>\u7b49\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b73-dic-2025-7-7\">73,74<\/a>\uff0c\u5411\u60a3\u6709\u56ca\u6027\u7ea4\u7ef4\u5316\u7684\u8f83<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\"><\/a>\u5927\u513f\u7ae5\uff08\u5e73\u5747\u5e74\u9f84\uff1a10.8\u3001<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">74<\/a>\u300113.9\u3001<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b75-dic-2025-7-7\">75<\/a>\u30019.5\u3001<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b73-dic-2025-7-7\">73<\/a>\u548c15.8\u5c81\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">74<\/a>\uff09\u6bcf\u65e5\u4e09\u6b21\u6ce8\u5c04200\u6beb\u514b\u3002\u6b64\u5916\uff0cStafanger\u7b49\u4eba\u4e3a\u4f53\u91cd&gt;30\u516c\u65a4\u7684<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">\u513f\u7ae5\u6bcf\u5929\u4e24\u6b21<\/a>\u63d0\u4f9b400\u6beb\u514b\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b73-dic-2025-7-7\"><\/a>\u7814\u7a76\u62a5\u544a\u4e86\u80ba\u529f\u80fd\u6539\u5584\u7684\u6df7\u5408\u7ed3\u679c\u3002Mitchell\u548cElliott<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b72-dic-2025-7-7\">72<\/a>\u53d1\u73b0PEFR\u672a\u663e\u8457\u53d8\u5316\uff0c\u800cRatjen\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b75-dic-2025-7-7\">\u4eba\u62a5\u544a\u4e86<\/a>\u4e0eNAC\u548c\u5b89\u5e03\u7f57\u7d22\u6cbb\u7597\u7ec4\u76f8\u6bd4\uff0c\u5b89\u6170\u5242\u7ec4\u80ba\u529f\u80fd\u635f\u5bb3\u660e\u663e\u589e\u52a0\u3002\u5728\u4ed6\u4eec\u7684\u7b2c\u4e00\u9879\u7814\u7a76\u4e2d\uff0cStafanger\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b73-dic-2025-7-7\">\u4eba\u89c2\u5bdf\u5230<\/a>\u80ba\u529f\u80fd\u5728\u79cb\u5b63\u6709\u6240\u6539\u5584\uff0c\u8fd9\u4e0e\u4e0b\u6c14\u9053\u611f\u67d3\u7684\u53d1\u75c5\u7387\u589e\u52a0\u76f8\u543b\u5408\u3002\u7136\u800c\uff0c\u5728\u540e\u7eed\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u53d1\u73b0\u75c5\u60c5\u8f83\u91cd\uff08PEFR&lt;\u4e3a\u9884\u6d4b\u503c\u768470%\uff09\u7684\u513f\u7ae5\uff0c\u80ba\u529f\u80fd\u663e\u8457\u6539\u5584\uff0c\u5305\u62ecPEFR\u3001FVC\u548cFEV<sub>1<\/sub>\u7684\u589e\u52a0\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b74-dic-2025-7-7\">74<\/a>&nbsp;\u8fd9\u8868\u660e\u8f83\u9ad8\u5242\u91cf\u7684NAC\u5728\u665a\u671f\u75be\u75c5\u4e2d\u53ef\u80fd\u7279\u522b\u6709\u76ca;\u7136\u800c\uff0c\u7597\u6548\u4f3c\u4e4e\u56e0\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u548c\u57fa\u7ebf\u80ba\u529f\u80fd\u800c\u5f02\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u4e0e\u53e3\u670d\u7ed9\u836f\u4e0d\u540c\uff0c\u5438\u5165\u548c\u96fe\u5316NAC\u5177\u6709\u76f4\u63a5\u5c06\u66f4\u9ad8\u6d53\u5ea6\u7684\u836f\u7269\u76f4\u63a5\u8f93\u9001\u5230\u6c14\u9053\u7684\u4f18\u52bf\uff0c\u53ef\u80fd\u589e\u5f3a\u5176\u9ecf\u6db2\u6eb6\u89e3\u6548\u679c\u3002\u8be5\u8def\u5f84\u5728\u6025\u6027\u548c\u6162\u6027\u73af\u5883\u4e2d\u90fd\u663e\u793a\u51fa\u6709\u5e0c\u671b\u7684\u6548\u679c\u300220,68,71,88,95,96 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href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b96-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b71-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b68-dic-2025-7-7\"><\/a>20,68,71,88,95,96<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b95-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b68-dic-2025-7-7\"><\/a>&nbsp;<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b67-dic-2025-7-7\">\u4e00\u4e9b\u7814\u7a76\u62a5\u544a<\/a>\u79f0\uff0c\u6c14\u6eb6\u80f6\u5316NAC\u6cbb\u7597\u7684\u80ba\u708e\u513f\u7ae5\u75c7\u72b6\u7f13\u89e3\u66f4\u5feb\uff0c\u708e\u75c7\u6807\u5fd7\u7269\u51cf\u5c11\uff0c\u5206\u522b\u4f18\u4e8e\u5e03\u5730\u5948\u5fb7\u548c\u5b89\u5e03\u7f57\u7d22\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b20-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b71-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b88-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b96-dic-2025-7-7\"><\/a><\/p>\n<p class=\"wp-block-paragraph\">\u5c3d\u7ba1NAC\u6709\u6548\uff0c\u5c24\u5176\u662f\u5438\u5165\u65b9\u5f0f\u4f7f\u7528\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u4e0e\u652f\u6c14\u7ba1\u75c9\u631b\u548c\u67d0\u4e9b\u513f\u79d1\u4eba\u7fa4\u7684\u547c\u5438\u9053\u53cd\u5411\u6076\u5316\u6709\u5173\u3002\u7279\u522b\u662f\u9ad8\u6d53\u5ea6\uff0820%\uff09\u6eb6\u6db2\u98ce\u9669\u6700\u5927\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b92-dic-2025-7-7\">92<\/a>&nbsp;\u5728\u54ee\u5598\u6216\u5df2\u6709\u6c14\u9053\u8fc7\u654f\u7684\u513f\u7ae5\u4e2d\u5c24\u4e3a\u660e\u663e\uff0c\u56e0\u6b64\u65e2\u4e0d\u88ab\u6307\u5f81\u4e5f\u4e0d\u83b7\u51c6\u7528\u4e8e\u9ecf\u6db2\u6eb6\u89e3\u5242\uff0c\u800c\u4f4e\u6d53\u5ea6\uff0810%\uff09\u6eb6\u6db2\u901a\u5e38\u8010\u53d7\u6027\u8981\u597d\u5f97\u591a\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b97-dic-2025-7-7\"><\/a>&nbsp;67,68,95 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u610f\u5927\u5229\u513f\u79d1\u8fc7\u654f\u4e0e\u514d\u75ab\u5b66\u4f1a\uff08SIAIP\uff09<mark class=\"has-inline-color has-vivid-cyan-blue-color\">\u5efa\u8bae\u4e0d\u8981\u5411\u54ee\u5598\u513f\u7ae5\u5f00\u5177\u9ecf\u6db2\u6eb6\u89e3\u5242\uff0c<\/mark>\u8fd9\u4e0e\u5305\u62ec\u5168\u7403\u54ee\u5598\u5021\u8bae\u3001\u7f8e\u56fd\u80f8\u8154\u5b66\u4f1a<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b98-dic-2025-7-7\">98<\/a>\u548c\u82f1\u56fd\u80f8\u8154\u5b66\u4f1a\u5728\u5185\u7684\u4e3b\u8981\u56fd\u9645\u6307\u5357\u7684\u5efa\u8bae\u4fdd\u6301\u4e00\u81f4\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b67-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b68-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b95-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b100-dic-2025-7-7\">99,100<\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b99-dic-2025-7-7\"><\/a><\/p>\n<p class=\"wp-block-paragraph\">\u786e\u51ff\u8bc1\u636e\u652f\u6301\u53e3\u670dNAC\u7684\u6700\u4f73\u5242\u91cf\u4e3a2\u5c81\u4ee5\u4e0a\u513f\u7ae5\u6bcf\u65e5200\u2013600\u6beb\u514b\uff0c\u5177\u4f53\u5242\u91cf\u56e0\u56fd\u5bb6\u548c\u5177\u4f53\u6cbb\u7597\u7528\u9014\u800c\u5f02\u3002\u8be5\u6cbb\u7597\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u8010\u53d7\u6027\u548c\u5f3a\u6709\u529b\u7684\u5b89\u5168\u6027\u300266,72,73,75,85,86,94 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cHashemian\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b63-dic-2025-7-7\">\u4eba\u62a5\u544a\u4e86<\/a>1200\u6beb\u514b\/\u5929\u53e3\u670dNAC\u5728\u4e2d\u5ea6COVID-19\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f8410.8\u201311.3\u5c81\uff09\u4e2d\u65e0\u526f\u4f5c\u7528\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b66-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b72-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b73-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b75-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b85-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b86-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b94-dic-2025-7-7\"><\/a>\u7136\u800c\uff0c\u7531\u4e8e\u6837\u672c\u91cf\u8f83\u5c0f\uff08<em>n<\/em>=25\uff09\uff0c\u8fd9\u4e9b\u7ed3\u679c\u5e94\u8c28\u614e\u89e3\u8bfb\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u53e3\u670dNAC\u7684\u914d\u65b9\u548c\u9002\u53e3\u6027\u95ee\u9898\u4f1a\u5f71\u54cd\u4f9d\u4ece\u6027\u3002Fiocchi\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b61-dic-2025-7-7\">\u4eba\u6307\u51fa\uff0c<\/a>4%\u7684\u60a3\u8005\u56e0\u5455\u5410\u800c\u505c\u6b62\u6cbb\u7597\uff0c\u8fd9\u5f88\u53ef\u80fd\u4e0eNAC\u7cd6\u6d46\u7684\u96be\u95fb\u5473\u9053\u6709\u5173\u3002\u6539\u5584\u53e3\u670dNAC\u7684\u53e3\u611f\u548c\u914d\u65b9\u6709\u52a9\u4e8e\u63d0\u9ad8\u4f9d\u4ece\u6027\u548c\u6574\u4f53\u6cbb\u7597\u6548\u679c\uff0c\u5c24\u5176\u662f\u5bf9\u96be\u95fb\u5473\u9053\u66f4\u654f\u611f\u7684\u5e7c\u513f\u3002<\/p>\n<p class=\"wp-block-paragraph\">2\u5c81\u4ee5\u4e0b\u7684\u5a74\u513f\u88ab\u63cf\u8ff0\u4e3a\u66f4\u5bb9\u6613\u53d1\u751f\u9ecf\u6db2\u6eb6\u89e3\u5242\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8fd9\u4e9b\u4e0d\u826f\u4e8b\u4ef6\u53ef\u80fd\u5305\u62ec\u547c\u5438\u9053\u611f\u67d3\u671f\u95f4\u53cd\u5bf9\u6027\u5730\u52a0\u91cd\u652f\u6c14\u7ba1\u548c\u6025\u6027\u547c\u5438\u7a98\u8feb\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b22-dic-2025-7-7\">22,23<\/a>&nbsp;\u8fd9\u4e9b\u98ce\u9669\u53ef\u80fd\u4e0e\u5242\u91cf\u76f8\u5173\uff0c\u4e14\u53ef\u80fd\u53d7\u5a74\u513f\u89e3\u5256\u548c\u751f\u7406\u5dee\u5f02\u5f71\u54cd\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b23-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b101-dic-2025-7-7\">22,101<\/a>&nbsp;\u6b64\u7c7b\u62c5\u5fe7\u4fc3\u4f7f\u6cd5\u56fd\u548c\u610f\u5927\u5229\u836f\u54c1\u673a\u6784\u9650\u52362\u5c81\u4ee5\u4e0b\u513f\u7ae5\u7684NAC\u548c\u78b3\u534a\u80f1\u6c28\u9178\u8bb8\u53ef\u8bc1\uff0c\u5efa\u8bae\u4e0d\u5728\u8be5\u5e74\u9f84\u6bb5\u5e38\u89c4\u4f7f\u7528\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b22-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b101-dic-2025-7-7\">22,101<\/a>&nbsp;\u8fd9\u4e00\u76d1\u7ba1\u884c\u52a8\u51f8\u663e\u4e86\u513f\u79d1\u4eba\u7fa4\u7684\u7279\u6b8a\u8106\u5f31\u6027\uff0c\u5e76\u5f3a\u8c03\u4e86\u8c28\u614e\u3001\u5faa\u8bc1\u7684\u5242\u91cf\u7ba1\u7406\u7684\u91cd\u8981\u6027\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b22-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b22-dic-2025-7-7\">22<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u6839\u636e\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u4e0e\u9884\u9632\u4e2d\u5fc3\u7684\u751f\u957f\u56fe\u8868\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#f3-dic-2025-7-7\">\u89c1\u56fe3<\/a>\uff09\uff0c4\u5c81\u513f\u7ae5\u7684\u4e2d\u4f4d\u4f53\u91cd\u7ea6\u4e3a16\u516c\u65a4\uff0c\u800c9\u5c81\u513f\u7ae5\u7ea6\u4e3a29\u516c\u65a4\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b102-dic-2025-7-7\">102,103<\/a>&nbsp;\u5728\u8fd9\u4e00\u5e7f\u6cdb\u7684\u5e74\u9f84\u548c\u4f53\u91cd\u8303\u56f4\u5185\u65bd\u7528\u76f8\u540c\u5242\u91cf\uff0c\u4f7f\u5f97\u66f4\u5e74\u8f7b\u3001\u8f83\u8f7b\u7684\u513f\u7ae5\u66b4\u9732\u5728\u66f4\u9ad8\u5242\u91cf\u7684\u6bcf\u516c\u65a4\u5242\u91cf\u4e2d\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b103-dic-2025-7-7\"><\/a>\u9274\u4e8e2\u81f312\u5c81\u4e4b\u95f4\u4f53\u91cd\u6ce2\u52a8\u8f83\u5927\uff0c\u5c24\u5176\u662f2\u81f36\u20137\u5c81\u53ca6\u20137\u81f312\u5c81\u4e4b\u95f4\uff0c\u4f53\u91cd\u8c03\u6574\u5242\u91cf\u548c\u5e74\u9f84\u5b9a\u4e49\u9608\u503c\u5c06\u4f18\u5316\u7597\u6548\u548c\u8010\u53d7\u6027\uff08<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#f3-dic-2025-7-7\">\u89c1\u56fe3<\/a>\uff09\u3002\u6839\u636e\u5e74\u9f84\u7ec4\u548c\u75c7\u72b6\u4e25\u91cd\u7a0b\u5ea6\u8c03\u6574\u5242\u91cf\uff0c\u53ef\u4ee5\u5728\u6700\u5927\u9650\u5ea6\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u7684\u540c\u65f6\uff0c\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u6240\u9700\u5242\u91cf\u548c\u526f\u4f5c\u7528\u98ce\u9669\u3002<\/p>\n<figure class=\"wp-block-image\" id=\"f3-dic-2025-7-7\"><a class=\"tileshop\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=12657002_DIC-2025-7-7-BENEDETTI-Figure3.jpg\" data-lightbox=\"image_lg\"><img title=\"NAC\u5728\u513f\u79d1\u4e2d\u7684\u5e94\u7528\uff1a\u547c\u5438\u62a4\u7406\u4e2d\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u5242\u91cf\u7b56\u7565\u7efc\u8ff0 - \u7b2c4\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"NAC\u5728\u513f\u79d1\u4e2d\u7684\u5e94\u7528\uff1a\u547c\u5438\u62a4\u7406\u4e2d\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u5242\u91cf\u7b56\u7565\u7efc\u8ff0 - \u7b2c4\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\"  width=\"689\" height=\"449\"  data-src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;689&#039;%20height=&#039;449&#039;%20viewBox=&#039;0%200%20689%20449&#039;%3E%3C\/svg%3E\" class=\"wp-image-9793 perfmatters-lazy\" data-src=\"https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2025\/12\/DIC-2025-7-7-BENEDETTI-Figure3.jpg\" data-srcset=\"https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2025\/12\/DIC-2025-7-7-BENEDETTI-Figure3.jpg 689w, https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2025\/12\/DIC-2025-7-7-BENEDETTI-Figure3-300x196.jpg 300w\" data-sizes=\"(max-width: 689px) 100vw, 689px\" \/><img loading=\"lazy\" decoding=\"async\" title=\"NAC\u5728\u513f\u79d1\u4e2d\u7684\u5e94\u7528\uff1a\u547c\u5438\u62a4\u7406\u4e2d\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u5242\u91cf\u7b56\u7565\u7efc\u8ff0 - \u7b2c5\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"NAC\u5728\u513f\u79d1\u4e2d\u7684\u5e94\u7528\uff1a\u547c\u5438\u62a4\u7406\u4e2d\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u5242\u91cf\u7b56\u7565\u7efc\u8ff0 - \u7b2c5\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" width=\"689\" height=\"449\" src=\"https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2025\/12\/DIC-2025-7-7-BENEDETTI-Figure3.jpg\" class=\"wp-image-9793\" \/><\/a><figcaption class=\"wp-element-caption\">\u9488\u5bf92\u81f320\u5c81\u5973\u5b69<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b102-dic-2025-7-7\">102<\/a>\u5c81\uff08A\uff09\u548c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b103-dic-2025-7-7\">\u7537\u5b69103<\/a>\u5c81\uff08B\uff09\u7684\u8eab\u9ad8\u53ca\u4f53\u91cd\u968f\u5e74\u9f84\u589e\u957f\u8868\uff0c\u63a8\u8350N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\uff08NAC\uff09\u57fa\u4e8e\u5e74\u9f84\u7684\u53e3\u670d\u5242\u91cf\u3002\u8d44\u6599\u6765\u6e90\uff1a\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u4e0e\u9884\u9632\u4e2d\u5fc3\u3002\u63d0\u53ca\u7279\u5b9a\u7684\u5546\u4e1a\u4ea7\u54c1\u3001\u5236\u9020\u5546\u3001\u516c\u53f8\u6216\u5546\u6807\uff0c\u5e76\u4e0d\u6784\u6210\u7f8e\u56fd\u653f\u5e9c\u3001\u536b\u751f\u4e0e\u516c\u5171\u670d\u52a1\u90e8\u6216\u75be\u75c5\u63a7\u5236\u4e0e\u9884\u9632\u4e2d\u5fc3\u7684\u80cc\u4e66\u6216\u63a8\u8350\u3002<\/figcaption><\/figure>\n<p class=\"wp-block-paragraph\">\u5173\u4e8eNAC\u57282\u5c81\u4ee5\u4e0b\u5a74\u513f\u4e2d\u7684\u6548\u529b\u548c\u5b89\u5168\u6027\u8bc1\u636e\u6709\u9650\u3002Naz\u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b95-dic-2025-7-7\">95<\/a>\u548cPandey\u7b49\u4eba<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b96-dic-2025-7-7\">96<\/a>\u7684\u7814\u7a76\u4e3a\u8fdb\u4e00\u6b65\u7814\u7a76\u63d0\u4f9b\u4e86\u57fa\u7840\uff0c\u652f\u6301\u96fe\u5316NAC\u5728\u6cbb\u7597\u6025\u6027\u75c5\u6bd2\u6027\u7ec6\u652f\u6c14\u7ba1\u708e\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5373\u4f7f\u662f\u5728\u975e\u5e38\u5e74\u5e7c\u7684\u513f\u7ae5\u4e2d\u4e5f\u662f\u5982\u6b64\u3002\u7136\u800c\uff0c2\u5c81\u4ee5\u4e0b\u7684\u5e38\u89c4\u9972\u517b\u4ecd\u9700\u4ed4\u7ec6\u8bc4\u4f30\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u4e00\u4e9b\u957f\u671f\u7814\u7a76\u9002\u7528\u4e8e\u60a3\u6709\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u513f\u79d1\u60a3\u8005\u3002Stephan\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b86-dic-2025-7-7\">\u4eba\u62a5\u544a\uff0c<\/a>\u4f7f\u7528NAC\u53e3\u670d\u6216\u5438\u5165\u6cbb\u7597\u57282\u5e74\u95f4\u7684\u513f\u79d1\u56ca\u6027\u7ea4\u7ef4\u5316\u60a3\u8005\u65e0\u4e0d\u826f\u53cd\u5e94\u3002\u4ed6\u4eec\u5f97\u51fa\u7ed3\u8bba\uff0c\u53e3\u670dNAC\u7597\u6cd5\u4e0d\u4f1a\u5f15\u8d77\u5438\u5165\u836f\u7269\u5076\u5c14\u89c2\u5bdf\u5230\u7684\u526f\u4f5c\u7528\uff0c\u5e76\u5efa\u8bae\u53e3\u670dNAC\u4f5c\u4e3a\u957f\u671f\u56ca\u6027\u7ea4\u7ef4\u5316\u6cbb\u7597\u7684\u53ef\u884c\u66ff\u4ee3\u65b9\u6848\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b86-dic-2025-7-7\">86<\/a>&nbsp;\u540c\u6837\uff0cReas\u7b49\u4eba\u7684\u7814\u7a76\u663e\u793a\uff0c<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b87-dic-2025-7-7\">87<\/a>\u4e2a\u96fe\u5316NAC\u5728CF\u60a3\u8005\u4e09\u5e74\u968f\u8bbf\u671f\u95f4\u8010\u53d7\u826f\u597d\uff0c\u672a\u89c2\u5bdf\u5230\u957f\u671f\u6bd2\u6027\u53cd\u5e94\u3002\u7136\u800c\uff0cDietzsch\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b85-dic-2025-7-7\">\u4eba\u5728\u513f<\/a>\u79d1\u56ca\u6027\u7ea4\u7ef4\u5316\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u53e3\u670dNAC\u7684\u7597\u6548\u4f4e\u4e8e\u96fe\u5316NAC\uff0c\u5efa\u8bae\u53e3\u670d\u6cbb\u7597\u4ec5\u5728\u7279\u5b9a\u75c5\u4f8b\u4e2d\u66ff\u4ee3\u5438\u5165\u3002NAC\u5386\u53f2\u4e0a\u4e00\u76f4\u7528\u4e8e\u6162\u6027\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u5982\u56ca\u6027\u7ea4\u7ef4\u5316\uff08CF\uff09\uff0c\u4f46\u5373\u4f7f\u6cbb\u7597\u5468\u671f\u8f83\u957f\uff0c\u4e5f\u6ca1\u6709\u4efb\u4f55\u53cd\u5bf9\u5176\u4f7f\u7528\u7684\u6587\u732e\u5efa\u8bae\u3002<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b86-dic-2025-7-7\">25,86,87<\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b25-dic-2025-7-7\"><\/a><a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b87-dic-2025-7-7\"><\/a><\/p>\n<p class=\"wp-block-paragraph\">\u6b64\u5916\uff0cNAC\u4e0e\u5176\u4ed6\u836f\u7269\u5982\u5e03\u5730\u5948\u5fb7\u8054\u5408\u4f7f\u7528\uff08\u5982Chen\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b67-dic-2025-7-7\">67<\/a>\u548cWang\u7b49<a href=\"\/\/https_pmc.ncbi.nlm.nih.gov\/?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC12657002%2F#b89-dic-2025-7-7\">89<\/a>\u7684\u7814\u7a76\u6240\u793a\uff09\uff0c\u663e\u793a\u51fa\u63d0\u5347\u6cbb\u7597\u6548\u679c\u7684\u524d\u666f\u3002\u63a2\u7d22\u534f\u540c\u6548\u5e94\u5e76\u4f18\u5316\u7ec4\u5408\u65b9\u6848\uff0c\u6709\u671b\u6269\u5927NAC\u5728\u513f\u79d1\u547c\u5438\u62a4\u7406\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>\u7ed3\u8bba<\/h2>\n<p class=\"wp-block-paragraph\">NAC\u5728\u513f\u79d1\u4eba\u7fa4\u4e2d\u5df2\u88ab\u5e7f\u6cdb\u7814\u7a76\uff0c\u662f\u5e74\u8f7b\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u60a3\u8005\u7684\u5b9d\u8d35\u6cbb\u7597\u9009\u62e9\uff0c\u5728\u6025\u6027\u548c\u6162\u6027\u73af\u5883\u4e2d\u5747\u6709\u5145\u5206\u8bc1\u636e\u8bc1\u660e\u5176\u7597\u6548\u3002\u57fa\u4e8e\u4f53\u91cd\u7684\u5242\u91cf\u65b9\u6cd5\u53ef\u80fd\u6709\u52a9\u4e8e\u6cbb\u7597\u4f18\u5316\uff0c\u5c24\u5176\u662f\u5728\u66f4\u5e74\u5e7c\u7684\u513f\u7ae5\u4e2d\u3002\u672a\u6765\u7684\u7814\u7a76\u5e94\u8fdb\u4e00\u6b65\u63a2\u8ba8\u5242\u91cf-\u53cd\u5e94\u5173\u7cfb\u3001\u957f\u671f\u5b89\u5168\u6027\u3001\u6f5c\u5728\u534f\u540c\u6548\u5e94\uff0c\u4ee5\u53ca\u5f00\u53d1\u65b0\u914d\u65b9\u4ee5\u6539\u5584\u8010\u53d7\u6027\u3001\u6613\u5165\u53e3\u6027\u548c\u4f9d\u4ece\u6027\uff0c\u5e76\u652f\u6301\u91cf\u8eab\u5b9a\u5236\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u4ee5\u6700\u5927\u5316\u6548\u76ca\u5e76\u6700\u5c0f\u5316\u98ce\u9669\u3002<\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>\u8865\u5145\u4fe1\u606f<\/h2>\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/instance\/12657002\/bin\/dic.2025-7-7-PLS.pdf\">dic.2025-7-7-PLS.pdf<\/a><sup>\uff0861.7KB\uff0cpdf\uff09<\/sup><\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>\u81f4\u8c22<\/h2>\n<p class=\"wp-block-paragraph\">\u7f16\u8f91\u5de5\u4f5c\u7531\u74e6\u83b1\u91cc\u5a05\u00b7\u8d1d\u5185\u675c\u897f\u3001\u897f\u8499\u5185\u5854\u00b7\u5e15\u5e15\u3001\u74e6\u4f26\u8482\u5a1c\u00b7\u963f\u5854\u7eb3\u897f\u5965\u548c\u963f\u4ec0\u5c3c\u00b7\u6c99\u963f\uff08\u610f\u5927\u5229\u7c73\u5170Polistudium S.r.l.\uff09\u63d0\u4f9b\uff0c\u5e76\u5f97\u5230Zambon S.p.A.\u7684\u652f\u6301\u3002<\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>\u6ce8\u91ca<\/h2>\n<p class=\"wp-block-paragraph\"><strong>\u8d21\u732e\uff1a<\/strong>\u7814\u7a76\u6784\u601d\u4e0e\u8bbe\u8ba1\uff1aFB\uff0cPS;\u6570\u636e\u6536\u96c6\u4e0e\u89e3\u8bfb\uff1aPS;\u624b\u7a3f\u8d77\u8349\uff1aFB;\u624b\u7a3f\u7f16\u8f91\uff1aFB\uff0cPS;\u63d0\u4ea4\u6279\u51c6\uff1aFacebook\uff0cPS\u3002\u6240\u6709\u7f72\u540d\u4f5c\u8005\u5747\u7b26\u5408\u56fd\u9645\u533b\u5b66\u671f\u520a\u7f16\u8f91\u59d4\u5458\u4f1a\uff08ICMJE\uff09\u5bf9\u672c\u6587\u4f5c\u8005\u8d44\u683c\u7684\u6807\u51c6\uff0c\u5bf9\u6574\u4f53\u4f5c\u54c1\u7684\u5b8c\u6574\u6027\u8d1f\u8d23\uff0c\u5e76\u5df2\u6279\u51c6\u672c\u7248\u672c\u7684\u53d1\u8868\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u62ab\u9732\u53ca\u6f5c\u5728\u5229\u76ca\u51b2\u7a81\uff1a<\/strong>Facebook\u58f0\u660e\u6ca1\u6709\u5229\u76ca\u51b2\u7a81;PS\u66fe\u83b7\u5f97\u963f\u65af\u5229\u5eb7\u3001\u67cf\u6797\u5316\u5b66\u3001\u57c3\u5fb7\u8499\u6cd5\u739b\u3001\u65b0\u6cd5\u533b\u5b66\u3001\u845b\u5170\u7d20\u53f2\u514b\u3001Zambon International\u3001Domp\u00e8\u548c\u8d5b\u8bfa\u83f2\u7b49\u516c\u53f8\u7684\u8bb2\u5ea7\u8d39\u548c\u54a8\u8be2\u8d39;\u83b7\u5f97\u57c3\u5fb7\u8499\u5fb7\u6cd5\u739b\u3001\u845b\u5170\u7d20\u53f2\u514b\u548c\u963f\u65af\u5229\u5eb7\u7684\u7814\u7a76\u8d44\u52a9\u3002\u56fd\u9645\u533b\u5b66\u671f\u520a\u7f16\u8f91\u59d4\u5458\u4f1a\uff08ICMJE\uff09\u4f5c\u8005\u6f5c\u5728\u5229\u76ca\u51b2\u7a81\u8868\u683c\u53ef\u901a\u8fc7\u4ee5\u4e0b\u7f51\u7ad9\u4e0b\u8f7d\uff1a<a href=\"https:\/\/www.drugsincontext.com\/wp-content\/uploads\/2025\/10\/dic.2025-7-7-COI.pdf\">https:\/\/www.drugsincontext.com\/wp-content\/uploads\/2025\/10\/dic.2025-7-7-COI.pdf<\/a><\/p>\n<p class=\"wp-block-paragraph\"><strong>\u8d44\u91d1\u58f0\u660e\uff1a<\/strong>\u7f16\u8f91\u534f\u52a9\u5f97\u5230\u4e86Zambon S.p.A.\u7684\u652f\u6301\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u6b63\u786e\u5f52\u5c5e\uff1a<\/strong>\u7248\u6743\u6240\u6709 \u00a9 2025 Benedetti F\uff0c Santus P.&nbsp;<a href=\"https:\/\/doi.org\/10.7573\/dic.2025-7-7\">https:\/\/doi.org\/10.7573\/dic.2025-7-7<\/a>\u3002\u7531<em>Drugs in Context<\/em>\u53d1\u5e03\uff0c\u91c7\u7528\u77e5\u8bc6\u5171\u4eab\u8bb8\u53ef\u5951\u7ea6CC BY NC ND 4.0\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u6587\u7ae0\u7f51\u5740\uff1a<\/strong><a href=\"https:\/\/www.drugsincontext.com\/n-acetylcysteine-in-paediatrics-a-review-of-efficacy-safety-and-dosing-strategies-in-respiratory-care\">https:\/\/www.drugsincontext.com\/n-acetylcysteine-in-paediatrics-a-review-of-efficacy-safety-and-dosing-strategies-in-respiratory-care<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u6765\u6e90<strong>\uff1a<\/strong>\u63d0\u4ea4;\u5916\u90e8\u540c\u884c\u8bc4\u5ba1\u3002<\/p>\n<p class=\"wp-block-paragraph\"><em>\u300a\u836f\u7269\u8bed\u5883\u300b<\/em>\u7531BioExcel\u51fa\u7248\u6709\u9650\u516c\u53f8\u51fa\u7248\u3002\u6ce8\u518c\u5730\u5740\uff1a\u4f26\u6566\u65b0\u57c3\u5c14\u745f\u59c6Green Lane\u5546\u52a1\u56ed6\u53f7\uff0c238 Green Lane\uff0c\u90ae\u7f16SE9 3TL\uff0c\u82f1\u56fd\u3002<\/p>\n<p class=\"wp-block-paragraph\">BioExcel Publishing Limited \u5728\u82f1\u683c\u5170\u6ce8\u518c\u7f16\u53f710038393\u3002\u589e\u503c\u7a0e GB 252 7720 07\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u5982\u6709\u6240\u6709\u624b\u7a3f\u548c\u6295\u7a3f\u54a8\u8be2\uff0c\u8bf7\u8054\u7cfb\u7f16\u8f91\u90e8&nbsp;editorial@drugsincontext.com<\/p>\n<p class=\"wp-block-paragraph\">\u5982\u9700\u6240\u6709\u8bb8\u53ef\u3001\u6743\u5229\u548c\u8f6c\u8f7d\uff0c\u8bf7\u8054\u7cfbDavid Hughes&nbsp;david.hughes@bioexcelpublishing.com<\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>\u6570\u636e\u548c\u8d44\u6599\u7684\u53ef\u7528\u6027<\/h2>\n<p class=\"wp-block-paragraph\">\u652f\u6301\u672c\u6587\u7ed3\u8bba\u7684\u539f\u59cb\u6570\u636e\u5c06\u7531\u4f5c\u8005\u6839\u636e\u8981\u6c42\u63d0\u4f9b\u3002<\/p>\n<h2 class=\"wp-block-heading\"><a><\/a>\u53c2\u8003\u6587\u732e<\/h2>\n<ul class=\"wp-block-list\">\n<li>1.&nbsp;Santus P\uff0c Signorello JC\uff0c Danzo F\uff0c Lazzaroni G\uff0c Saad M\uff0c Radovanovic D. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u6297\u708e\u548c\u6297\u6c27\u5316\u7279\u6027\uff1a\u65b0\u89c6\u89d2\u3002J Clin Med. 2024;13(14):4127.DOI\uff1a10.3390\/JCM13144127\u3002[<a href=\"https:\/\/doi.org\/10.3390\/jcm13144127\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11278452\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39064168\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Clin%20Med&amp;title=Anti-inflammatory%20and%20anti-oxidant%20properties%20of%20N-acetylcysteine:%20a%20fresh%20perspective&amp;author=P%20Santus&amp;author=JC%20Signorello&amp;author=F%20Danzo&amp;author=G%20Lazzaroni&amp;author=M%20Saad&amp;volume=13&amp;issue=14&amp;publication_year=2024&amp;pages=4127&amp;pmid=39064168&amp;doi=10.3390\/jcm13144127&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>2.&nbsp;\u7279\u8bfa\u91cc\u5965MCDS\uff0c\u683c\u62c9\u897f\u5229\u4e9a\u8bfaNG\uff0c\u83ab\u62c9FA\uff0c\u5965\u5229\u7ef4\u62c9ACMD\uff0c\u53e4\u62c9\u7279MOF\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\uff08NAC\uff09\uff1a\u5bf9\u4eba\u4f53\u5065\u5eb7\u7684\u5f71\u54cd\u3002\u6297\u6c27\u5316\u5242\u30022021;10(6):967.DOI\uff1a10.3390\/antiox10060967\u3002[<a href=\"https:\/\/doi.org\/10.3390\/antiox10060967\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8234027\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34208683\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Antioxidants&amp;title=N-acetylcysteine%20(NAC):%20impacts%20on%20human%20health&amp;author=MCDS%20Ten%C3%B3rio&amp;author=NG%20Graciliano&amp;author=FA%20Moura&amp;author=ACMD%20Oliveira&amp;author=MOF%20Goulart&amp;volume=10&amp;issue=6&amp;publication_year=2021&amp;pages=967&amp;pmid=34208683&amp;doi=10.3390\/antiox10060967&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>3.&nbsp;Olivieri D\uff0c Marsico SA\uff0c Del Donno M. \u9ecf\u6db2\u6eb6\u89e3\u5242\u6539\u5584\u5438\u70df\u8005\u9ecf\u6db2\u7ea4\u6bdb\u8fd0\u8f93\u3002\u300a\u6b27\u6d32\u8bc4\u8bba\u6742\u5fd7\u300b\u8865\u7f16\uff0c1985\u5e74;139\uff1a142\u2013145\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3862608\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20J%20Respir%20Dis%20Suppl&amp;title=Improvement%20of%20mucociliary%20transport%20in%20smokers%20by%20mucolytics&amp;author=D%20Olivieri&amp;author=SA%20Marsico&amp;author=M%20Del%20Donno&amp;volume=139&amp;publication_year=1985&amp;pages=142-145&amp;pmid=3862608&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>4.&nbsp;Rogliani P\uff0c Manzetti GM\uff0c Gholamalishahi S\uff0c Cazzola M\uff0c Calzetta L. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9\u6c14\u9053\u9ecf\u6db2\u8fc7\u5ea6\u5206\u6ccc\u7684\u5f71\u54cd\uff1a\u7cfb\u7edf\u7efc\u8ff0\u3002\u56fd\u9645\u6742\u5fd7 2024\u5e74\u80ba\u963b\u585e\u7814\u7a76;19:2347\u20132360.DOI\uff1a10.2147\/COPD\u3002S474512\u3002[<a href=\"https:\/\/doi.org\/10.2147\/COPD.S474512\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11531296\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39493366\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int%20J%20Chron%20Obstruct%20Pulmon%20Dis&amp;title=Impact%20of%20N-acetylcysteine%20on%20mucus%20hypersecretion%20in%20the%20airways:%20a%20systematic%20review&amp;author=P%20Rogliani&amp;author=GM%20Manzetti&amp;author=S%20Gholamalishahi&amp;author=M%20Cazzola&amp;author=L%20Calzetta&amp;volume=19&amp;publication_year=2024&amp;pages=2347-2360&amp;pmid=39493366&amp;doi=10.2147\/COPD.S474512&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>5.&nbsp;\u65bd\u96f7\u514b R\uff0c\u8fc8\u5c14 B\uff0c\u66fc\u5185\u5c14 DN\uff0c\u5fb7\u7f57\u683c W\uff0c\u9c8d\u5c14\u52d2 PA\u3002\u4e8c\u786b\u4ee3\u6c28\u57fa\u7532\u9178\u916f\u4f5c\u4e3a\u5b8c\u6574\u7ec6\u80de\u4e2d\u6838\u56e0\u5b50\u03bab\u6fc0\u6d3b\u7684\u5f3a\u6548\u6291\u5236\u5242\u30021992\u5e74\u300a\u533b\u5b66\u7814\u7a76\u6742\u5fd7\u300b;175(5):1181\u20131194.\u6570\u636e\u6765\u6e90\uff1a10.1084\/JEM.175.5.1181\u3002[<a href=\"https:\/\/doi.org\/10.1084\/jem.175.5.1181\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2119220\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1314883\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Exp%20Med&amp;title=Dithiocarbamates%20as%20potent%20inhibitors%20of%20nuclear%20factor%20kappa%20B%20activation%20in%20intact%20cells&amp;author=R%20Schreck&amp;author=B%20Meier&amp;author=DN%20M%C3%A4nnel&amp;author=W%20Dr%C3%B6ge&amp;author=PA%20Baeuerle&amp;volume=175&amp;issue=5&amp;publication_year=1992&amp;pages=1181-1194&amp;pmid=1314883&amp;doi=10.1084\/jem.175.5.1181&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>6.&nbsp;Blackwell TS\u3001Blackwell TR\u3001Holden EP\u3001Christman BW\u3001Christman JW\u3002\u4f53\u5185\u6297\u6c27\u5316\u6cbb\u7597\u6291\u5236\u6838\u56e0\u5b50\u03ba-B\u6fc0\u6d3b\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u80ba\u90e8\u708e\u75c7\u3002\u300a\u514d\u75ab\u5b66\u6742\u5fd7\u300b\u30021996;157\uff084\uff09\uff1a1630\u20131637\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8759749\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Immunol&amp;title=In%20vivo%20antioxidant%20treatment%20suppresses%20nuclear%20factor-kappa%20B%20activation%20and%20neutrophilic%20lung%20inflammation&amp;author=TS%20Blackwell&amp;author=TR%20Blackwell&amp;author=EP%20Holden&amp;author=BW%20Christman&amp;author=JW%20Christman&amp;volume=157&amp;issue=4&amp;publication_year=1996&amp;pages=1630-1637&amp;pmid=8759749&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>7.&nbsp;Desaki M\uff0c Takizawa H\uff0c Kasama T\uff0c Kobayashi K\uff0c Morita Y\uff0c Yamamoto K. \u4eba\u7c7b\u652f\u6c14\u7ba1\u4e0a\u76ae\u7ec6\u80de\u5728\u7845\u8bf1\u5bfc\u767d\u4ecb\u7d208\u4e2d\u6838\u56e0\u5b50\u03ba-b\u7684\u6d3b\u5316\u3002\u7ec6\u80de\u56e0\u5b50\u30022000;12(8):1257\u20131260.DOI\uff1a10.1006\/cyto.2000.0704\u3002[<a href=\"https:\/\/doi.org\/10.1006\/cyto.2000.0704\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10930308\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cytokine&amp;title=Nuclear%20factor-kappa%20b%20activation%20in%20silica-induced%20interleukin%208%20production%20by%20human%20bronchial%20epithelial%20cells&amp;author=M%20Desaki&amp;author=H%20Takizawa&amp;author=T%20Kasama&amp;author=K%20Kobayashi&amp;author=Y%20Morita&amp;volume=12&amp;issue=8&amp;publication_year=2000&amp;pages=1257-1260&amp;pmid=10930308&amp;doi=10.1006\/cyto.2000.0704&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>8.&nbsp;Palacio JR\uff0c Markert UR\uff0c Mart\u00ednez P. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9\u8102\u591a\u7cd6\u6fc0\u6d3b\u5de8\u566c\u7ec6\u80de\u7684\u6297\u708e\u7279\u6027\u3002Inflamm\u7814\u7a76\uff0c2011\u5e74;60(7):695\u2013704.DOI\uff1a10.1007\/S00011-011-0323-8\u3002[<a href=\"https:\/\/doi.org\/10.1007\/s00011-011-0323-8\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21424515\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Inflamm%20Res&amp;title=Anti-inflammatory%20properties%20of%20N-acetylcysteine%20on%20lipopolysaccharide-activated%20macrophages&amp;author=JR%20Palacio&amp;author=UR%20Markert&amp;author=P%20Mart%C3%ADnez&amp;volume=60&amp;issue=7&amp;publication_year=2011&amp;pages=695-704&amp;pmid=21424515&amp;doi=10.1007\/s00011-011-0323-8&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>9.&nbsp;Oliva A\uff0c Pallecchi L\uff0c Rossolini GM\uff0c Travaglino F\uff0c Zanatta P. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u8f85\u52a9\u7528\u4e8e\u591a\u91cd\u8010\u836f\u611f\u67d3\u7684\u7406\u7531\u4e0e\u8bc1\u636e\u30022023\u5e74\u6b27\u6d32\u533b\u5b66\u836f\u5b66\u8bc4\u8bba;27(9):4316\u20134325.DOI\uff1a10.26355\/eurrev_202305_32342\u3002[<a href=\"https:\/\/doi.org\/10.26355\/eurrev_202305_32342\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37203858\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20Rev%20Med%20Pharmacol%20Sci&amp;title=Rationale%20and%20evidence%20for%20the%20adjunctive%20use%20of%20N-acetylcysteine%20in%20multidrug-resistant%20infections&amp;author=A%20Oliva&amp;author=L%20Pallecchi&amp;author=GM%20Rossolini&amp;author=F%20Travaglino&amp;author=P%20Zanatta&amp;volume=27&amp;issue=9&amp;publication_year=2023&amp;pages=4316-4325&amp;pmid=37203858&amp;doi=10.26355\/eurrev_202305_32342&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>10.&nbsp;Blasi F\uff0cPage C\uff0cRossolini GM \u7b49\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9\u751f\u7269\u819c\u7684\u5f71\u54cd\uff1a\u5bf9\u547c\u5438\u9053\u611f\u67d3\u6cbb\u7597\u7684\u542f\u793a\u3002Respir Med. 2016;117:190\u2013197.DOI\uff1a10.1016\/J.Rmed.2016.06.015\u3002[<a href=\"https:\/\/doi.org\/10.1016\/j.rmed.2016.06.015\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27492531\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Respir%20Med&amp;title=The%20effect%20of%20N-acetylcysteine%20on%20biofilms:%20implications%20for%20the%20treatment%20of%20respiratory%20tract%20infections&amp;author=F%20Blasi&amp;author=C%20Page&amp;author=GM%20Rossolini&amp;volume=117&amp;publication_year=2016&amp;pages=190-197&amp;pmid=27492531&amp;doi=10.1016\/j.rmed.2016.06.015&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>11.&nbsp;Oliva A\uff0c Bianchi A\uff0c Russo A \u7b49\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9\u7531\u5361\u9752\u9709\u70ef\u8010\u836f\u6027\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\u548c\u9c8d\u66fc\u4e0d\u52a8\u6746\u83cc\u5f15\u8d77\u7684\u8d25\u8840\u6027\u4f11\u514b\u4e25\u91cd\u60a3\u800530\u5929\u5185\u6b7b\u4ea1\u7387\u7684\u5f71\u54cd\uff1a\u4e00\u9879\u56de\u987e\u6027\u75c5\u4f8b\u5bf9\u7167\u7814\u7a76\u3002\u6297\u751f\u7d20\u30022021;10(3):271.DOI\uff1a10.3390\/antibiotics10030271\u3002[<a href=\"https:\/\/doi.org\/10.3390\/antibiotics10030271\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8001571\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33800296\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Antibiotics&amp;title=Effect%20of%20N-acetylcysteine%20administration%20on%2030-day%20mortality%20in%20critically%20ill%20patients%20with%20septic%20shock%20caused%20by%20carbapenem-resistant%20Klebsiella%20pneumoniae%20and%20Acinetobacter%20baumannii:%20a%20retrospective%20case-control%20study&amp;author=A%20Oliva&amp;author=A%20Bianchi&amp;author=A%20Russo&amp;volume=10&amp;issue=3&amp;publication_year=2021&amp;pages=271&amp;pmid=33800296&amp;doi=10.3390\/antibiotics10030271&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>12.&nbsp;\u6ce2\u5229\u5c3c\u00b7S\uff0c\u90a6\u5b54\u5e15\u5c3c\u00b7S\uff0c\u8fea\u00b7\u9a6c\u7126\u00b7T\u7b49\u3002\u4f53\u5916\u4e2d\uff0ccolistin\u4e0eN-\u4e59\u9170\u534a\u6c28\u9178\u8054\u5408\u5bf9\u6d6e\u6e38\u9636\u6bb5\u53ca\u751f\u7269\u819c\u4e2d\u57f9\u517b\u7684\u9c8d\u66fc\u4e0d\u52a8\u6746\u83cc\u4ea7\u751f\u534f\u540c\u4f5c\u7528\u3002\u300a\u6297\u83cc\u5316\u5b66\u836f\u300b\u6742\u5fd7\u30022018;73(9):2388\u20132395.DOI\uff1a10.1093\/JAC\/DKY185\u3002[<a href=\"https:\/\/doi.org\/10.1093\/jac\/dky185\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6105873\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29846610\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Antimicrob%20Chemother&amp;title=In%20vitro%20synergism%20of%20colistin%20in%20combination%20with%20N-acetylcysteine%20against%20Acinetobacter%20baumannii%20grown%20in%20planktonic%20phase%20and%20in%20biofilms&amp;author=S%20Pollini&amp;author=S%20Boncompagni&amp;author=T%20Di%20Maggio&amp;volume=73&amp;issue=9&amp;publication_year=2018&amp;pages=2388-2395&amp;pmid=29846610&amp;doi=10.1093\/jac\/dky185&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>13.&nbsp;Landini G\uff0c Di Maggio T\uff0c Sergio F\uff0c Docquier JD\uff0c Rossolini GM\uff0c Pallecchi L. \u9ad8N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u6d53\u5ea6\u5bf9\u6297\u751f\u7d20\u6d3b\u6027\u5bf9\u5927\u91cf\u547c\u5438\u9053\u75c5\u539f\u4f53\u7684\u5f71\u54cd\u3002\u6297\u83cc\u5242\u5316\u7597\u30022016;60(12):7513\u20137517.doi\uff1a10.1128\/AAC.01334-16\u3002[<a href=\"https:\/\/doi.org\/10.1128\/AAC.01334-16\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5119039\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27736757\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Antimicrob%20Agents%20Chemother&amp;title=Effect%20of%20high%20N-acetylcysteine%20concentrations%20on%20antibiotic%20activity%20against%20a%20large%20collection%20of%20respiratory%20pathogens&amp;author=G%20Landini&amp;author=T%20Di%20Maggio&amp;author=F%20Sergio&amp;author=JD%20Docquier&amp;author=GM%20Rossolini&amp;volume=60&amp;issue=12&amp;publication_year=2016&amp;pages=7513-7517&amp;pmid=27736757&amp;doi=10.1128\/AAC.01334-16&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>14.&nbsp;\u9a6c\u8bfa\u54c8\u5170 A\uff0c\u8fbe\u65af T\uff0c\u6000\u7279\u5229 GS\uff0c\u683c\u62c9\u65af\u6bd4 T\uff0c\u514b\u91cc\u5c14 FH\uff0c\u9a6c\u8bfa\u65af J.N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u8054\u5408\u6297\u751f\u7d20\u819c\u6cbb\u7597\u4e2d\u5bf9\u6297\u8010\u836f\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u7684\u5f71\u54cd\u3002\u300a\u6297\u83cc\u5316\u5b66\u836f\u300b\u6742\u5fd7\u30022020;75(7):1787\u20131798.DOI\uff1a10.1093\/JAC\/DKAA093\u3002[<a href=\"https:\/\/doi.org\/10.1093\/jac\/dkaa093\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32363384\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Antimicrob%20Chemother&amp;title=The%20effect%20of%20N-acetylcysteine%20in%20a%20combined%20antibiofilm%20treatment%20against%20antibiotic-resistant%20Staphylococcus%20aureus&amp;author=A%20Manoharan&amp;author=T%20Das&amp;author=GS%20Whiteley&amp;author=T%20Glasbey&amp;author=FH%20Kriel&amp;volume=75&amp;issue=7&amp;publication_year=2020&amp;pages=1787-1798&amp;pmid=32363384&amp;doi=10.1093\/jac\/dkaa093&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>15.\u8bb8BG\uff0c\u674eRP\uff0c\u6768FL\uff0c\u97e9\u6d2a\u6770\uff0c\u9648\u7199\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u6cbb\u7597\u540e\u53ef\u7f13\u89e3\u610f\u8bc6\u6e05\u9192\u5927\u9f20\u56e0\u5185\u6bd2\u7d20\u5f15\u8d77\u7684\u5668\u5b98\u635f\u4f24\u3002\u300a\u751f\u547d\u79d1\u5b66\u300b2006\u5e74;79(21):2010\u20132016.DOI\uff1a 10.1016\/J.Lfs.2006.06.040\u3002[<a href=\"https:\/\/doi.org\/10.1016\/j.lfs.2006.06.040\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16860347\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Life%20Sci&amp;title=Post-treatment%20with%20N-acetylcysteine%20ameliorates%20endotoxin%20shock-induced%20organ%20damage%20in%20conscious%20rats&amp;author=BG%20Hsu&amp;author=RP%20Lee&amp;author=FL%20Yang&amp;author=HJ%20Harn&amp;author=HI%20Chen&amp;volume=79&amp;issue=21&amp;publication_year=2006&amp;pages=2010-2016&amp;pmid=16860347&amp;doi=10.1016\/j.lfs.2006.06.040&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>16.&nbsp;Ergin B\u3001Guerci P\u3001Zafrani L \u7b49\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\uff08NAC\uff09\u8865\u5145\u4e8e\u590d\u82cf\u6db2\u4e2d\u5bf9\u80be\u5fae\u5faa\u73af\u6c27\u5408\u3001\u708e\u75c7\u53ca\u5927\u9f20\u5185\u6bd2\u7d20\u8840\u75c7\u6a21\u578b\u4e2d\u529f\u80fd\u7684\u5f71\u54cd\u30022016\u5e74\u91cd\u75c7\u76d1\u62a4\u533b\u5b66\u4e13\u9898;4(1):29.\u6570\u636e\u6765\u6e90\uff1a10.1186\/S40635-016-0106-1\u3002[<a href=\"https:\/\/doi.org\/10.1186\/s40635-016-0106-1\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5037099\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27671340\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Intensive%20Care%20Med%20Exp&amp;title=Effects%20of%20N-acetylcysteine%20(NAC)%20supplementation%20in%20resuscitation%20fluids%20on%20renal%20microcirculatory%20oxygenation,%20inflammation,%20and%20function%20in%20a%20rat%20model%20of%20endotoxemia&amp;author=B%20Ergin&amp;author=P%20Guerci&amp;author=L%20Zafrani&amp;volume=4&amp;issue=1&amp;publication_year=2016&amp;pages=29&amp;pmid=27671340&amp;doi=10.1186\/s40635-016-0106-1&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>17.&nbsp;\u8303\u6d69\u3001\u9eceJW\u3001\u6731JH\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u9884\u5904\u7406\u5bf9\u5316\u8840\u6027\u5927\u9f20\u6025\u6027\u80be\u635f\u4f24\u7684\u4fdd\u62a4\u4f5c\u7528\u3002\u5916\u79d1\u7814\u7a76\u6742\u5fd7 2020;254:125\u2013134.DOI\uff1a10.1016\/J.JSS.2020.04.017\u3002[<a href=\"https:\/\/doi.org\/10.1016\/j.jss.2020.04.017\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32438104\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Surg%20Res&amp;title=Protective%20effect%20of%20N-acetylcysteine%20pretreatment%20on%20acute%20kidney%20injury%20in%20septic%20rats&amp;author=H%20Fan&amp;author=JW%20Le&amp;author=JH%20Zhu&amp;volume=254&amp;publication_year=2020&amp;pages=125-134&amp;pmid=32438104&amp;doi=10.1016\/j.jss.2020.04.017&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>18.&nbsp;Bellomo G\uff0c Tirantello G\uff0c Giudice S. [\u5173\u4e8e\u4e59\u9170\u534a\u80f1\u6c28\u9178\u4e0e\u786b\u82ef\u4e8c\u915a\u7518\u6c28\u9178\u76d0\u5728\u513f\u7ae5\u652f\u6c14\u7ba1\u80ba\u611f\u67d3\u7cfb\u7edf\u6cbb\u7597\u4e2d\u7684\u5e94\u7528]\u3002\u514b\u6797\u513f\u79d1\u30021967;49\uff088\uff09\uff1a402\u2013424\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/5612769\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Clin%20Pediatr&amp;author=G%20Bellomo&amp;author=G%20Tirantello&amp;author=S%20Giudice&amp;volume=49&amp;issue=8&amp;publication_year=1967&amp;pages=402-424&amp;pmid=5612769&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>19.&nbsp;\u6851\u5766\u6770\u6d1b\u00b7G\uff0c\u9686\u5df4\u591a\u00b7S\uff0c\u8d3e\u8bfa\u8482\u00b7G.\u5934\u5b62\u544b\u8f9b\u548cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u7ec4\u5408\uff0c\u7528\u4e8e\u6cbb\u7597\u513f\u7ae5\u4e0b\u547c\u5438\u9053\u611f\u67d3\u3002Int J \u514b\u6797\u836f\u7269\u548c\u6bd2\u7d20\u30021985;23\uff085\uff09\uff1a279\u2013281\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/4008118\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int%20J%20Clin%20Pharmacol%20Ther%20Toxicol&amp;title=A%20combination%20of%20cefuroxime%20and%20N-acetyl-cysteine%20for%20the%20treatment%20of%20lower%20respiratory%20tract%20infections%20in%20children&amp;author=G%20Santangelo&amp;author=S%20Lombardo&amp;author=G%20Giannotti&amp;volume=23&amp;issue=5&amp;publication_year=1985&amp;pages=279-281&amp;pmid=4008118&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>20.&nbsp;\u624e\u7eb3\u897f\u00b7A\uff0c\u5361\u624e\u6258\u00b7S\uff0c\u963f\u666e\u91cc\u83b1\u00b7A\u7b49\u3002\u6297\u751f\u7d20\u5bf9\u6cbb\u7597\u6025\u6027\u6e7f\u54b3\u6709\u6548\u5417\uff1f\u56de\u987e\u6027\u7814\u7a76\u4e0e\u75c7\u72b6\u6cbb\u7597\u7684\u6bd4\u8f83\u3002\u591a\u5b66\u79d1\u547c\u5438\u533b\u5b66\uff0c2012\u5e74;7:3\u20134.\u7b2c\u4e00\u81f3\u7b2c\u4e94\u7ae0\u3002[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Multidiscip%20Respir%20Med&amp;title=Are%20antibiotics%20effective%20in%20treating%20children%20with%20acute%20moist%20cough?%20A%20retrospective%20study%20vs%20symptomatic%20therapy&amp;author=A%20Zanasi&amp;author=S%20Cazzato&amp;author=A%20Aprile&amp;volume=7&amp;publication_year=2012&amp;pages=3-4&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>21.&nbsp;Biscatti G\uff0c Bruschelli M\uff0c Damonte G\uff0c Capozzi F. [\u5173\u4e8e\u4e59\u9170\u534a\u80f1\u6c28\u9178\u53e3\u670d\u7ed9\u836f\u5bf9\u513f\u79d1\u547c\u5438\u9053\u611f\u67d3\u4e34\u5e8a\u6548\u5e94\u7684\u5bf9\u7167\u7814\u7a76]\u3002Minerva\u513f\u79d1\u533b\u751f\u30021972;24\uff0826\uff09\uff1a1075\u20131084\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/5069821\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Minerva%20Pediatr&amp;author=G%20Biscatti&amp;author=M%20Bruschelli&amp;author=G%20Damonte&amp;author=F%20Capozzi&amp;volume=24&amp;issue=26&amp;publication_year=1972&amp;pages=1075-1084&amp;pmid=5069821&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>22.&nbsp;Chalumeau M\uff0c Ch\u00e9ron G\uff0c Assathiany R \u7b49\u4eba [\u5a74\u513f\u6025\u6027\u547c\u5438\u9053\u611f\u67d3\u7684\u9ecf\u6db2\u6eb6\u89e3\u5242\uff1a\u836f\u7269\u6d41\u884c\u75c5\u5b66\u95ee\u9898\uff1f]\u3002\u300a\u5c0f\u5b66\u7814\u7a76\u300b\u3002 2002; 9(11):1128\u20131136. DOI\uff1a10.1016\/s0929-693x\uff0802\uff0900091-x\u3002[<a href=\"https:\/\/doi.org\/10.1016\/s0929-693x(02)00091-x\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12503503\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Arch%20Pediatr&amp;author=M%20Chalumeau&amp;author=G%20Ch%C3%A9ron&amp;author=R%20Assathiany&amp;volume=9&amp;issue=11&amp;publication_year=2002&amp;pages=1128-1136&amp;pmid=12503503&amp;doi=10.1016\/s0929-693x(02)00091-x&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>23.&nbsp;Mallet P\uff0c Mourdi N\uff0c Dubus JC \u7b49\u3002\u513f\u79d1\u60a3\u8005\u4e2d\u4e59\u9170\u534a\u80f1\u6c28\u9178\u548c\u78b3\u534a\u80f1\u6c28\u9178\u7cfb\u7edf\u6027\u4f7f\u7528\u76f8\u5173\u7684\u547c\u5438\u9053\u9006\u6027\u4e0d\u826f\u53cd\u5e94\uff1a\u4e00\u9879\u5168\u56fd\u8c03\u67e5\u3002PLoS One\u3002 2011; 6\uff087\uff09\uff1ae22792\u3002doi\uff1a10.1371\/journal.pone.0022792\u3002[<a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0022792\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3144941\/\">\u65e0PMC\u76f8\u5173\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21818391\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=PLoS%20One&amp;title=Respiratory%20paradoxical%20adverse%20drug%20reactions%20associated%20with%20acetylcysteine%20and%20carbocysteine%20systemic%20use%20in%20paediatric%20patients:%20a%20national%20survey&amp;author=P%20Mallet&amp;author=N%20Mourdi&amp;author=JC%20Dubus&amp;volume=6&amp;issue=7&amp;publication_year=2011&amp;pages=e22792&amp;pmid=21818391&amp;doi=10.1371\/journal.pone.0022792&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>24.&nbsp;\u60a3\u8005\u4fe1\u606f\u624b\u518c\uff1aFluimucil \u9ecf\u6db2\u6eb6\u89e3\u513f\u7ae5 100 mg\/5 ml \u7cd6\u6d46 N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u3002[\u8bbf\u95ee\u65e5\u671f\uff1a2025\u5e747\u670818\u65e5]\u3002<a href=\"https:\/\/api.aifa.gov.it\/aifa-bdf-eif-be\/1.0.0\/organizzazione\/7158\/farmaci\/34936\/stampati?ts=FI\">https:\/\/api.aifa.gov.it\/aifa-bdf-eif-be\/1.0.0\/organizzazione\/7158\/farmaci\/34936\/stampati?ts=FI<\/a>\u3002<\/li>\n<li>25.&nbsp;Mokra D\uff0c Mokry J\uff0c Barosova R\uff0c Hanusrichterova J. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u6162\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u4e2d\u7684\u5e94\u7528\u8fdb\u5c55\u3002\u6297\u6c27\u5316\u5242\u3002 2023; 12(9):1713. DOI\uff1a10.3390\/antiox12091713\u3002[<a href=\"https:\/\/doi.org\/10.3390\/antiox12091713\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10526097\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37760016\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Antioxidants&amp;title=Advances%20in%20the%20use%20of%20n-acetylcysteine%20in%20chronic%20respiratory%20diseases&amp;author=D%20Mokra&amp;author=J%20Mokry&amp;author=R%20Barosova&amp;author=J%20Hanusrichterova&amp;volume=12&amp;issue=9&amp;publication_year=2023&amp;pages=1713&amp;pmid=37760016&amp;doi=10.3390\/antiox12091713&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>26.&nbsp;Demedts M\uff0c Behr J\uff0c Buhl R \u7b49\u3002\u7279\u53d1\u6027\u80ba\u7ea4\u7ef4\u5316\u4e2d\u7684\u9ad8\u5242\u91cf\u4e59\u9170\u534a\u80f1\u6c28\u9178\u3002N Engl \u533b\u5b66\u6742\u5fd7\uff0c2005; 353(21):2229\u20132242. DOI\uff1a10.1056\/NEJMoa042976\u3002[<a href=\"https:\/\/doi.org\/10.1056\/NEJMoa042976\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16306520\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=N%20Engl%20J%20Med&amp;title=High-dose%20acetylcysteine%20in%20idiopathic%20pulmonary%20fibrosis&amp;author=M%20Demedts&amp;author=J%20Behr&amp;author=R%20Buhl&amp;volume=353&amp;issue=21&amp;publication_year=2005&amp;pages=2229-2242&amp;pmid=16306520&amp;doi=10.1056\/NEJMoa042976&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>27.&nbsp;Tirouvanziam R\uff0c Conrad CK\uff0c Bottiglieri T\uff0c Herzenberg LA\uff0c Moss RB\uff0c Herzenberg LA.\u9ad8\u5242\u91cf\u53e3\u670dN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\uff0c\u4e00\u79cd\u8c37\u80f1\u7518\u80bd\u524d\u836f\uff0c\u8c03\u8282\u56ca\u6027\u7ea4\u7ef4\u5316\u4e2d\u7684\u708e\u75c7\u3002\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u3002 2006; 103(12):4628\u20134633. DOI\uff1a10.1073\/PNAS.0511304103\u3002<a href=\"https:\/\/doi.org\/10.1073\/pnas.0511304103\">[DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1450222\/\">\u514d\u8d39PMC\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16537378\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20USA&amp;title=High-dose%20oral%20N-acetylcysteine,%20a%20glutathione%20prodrug,%20modulates%20inflammation%20in%20cystic%20fibrosis&amp;author=R%20Tirouvanziam&amp;author=CK%20Conrad&amp;author=T%20Bottiglieri&amp;author=LA%20Herzenberg&amp;author=RB%20Moss&amp;volume=103&amp;issue=12&amp;publication_year=2006&amp;pages=4628-4633&amp;pmid=16537378&amp;doi=10.1073\/pnas.0511304103&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>28.&nbsp;Tse HN\u3001Raiteri L\u3001Wong KY \u7b49\u3002\u9ad8\u5242\u91cfN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u7a33\u5b9aCOPD\u4e2d\u7684\u5e94\u7528\uff1a\u4e00\u9879\u4e3a\u671f1\u5e74\u7684\u53cc\u76f2\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167HIACE\u7814\u7a76\u3002\u80f8\u90e8\u3002 2013; 144(1):106\u2013118. DOI\uff1a10.1378\/chest.12-2357\u3002[<a href=\"https:\/\/doi.org\/10.1378\/chest.12-2357\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23348146\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chest&amp;title=High-dose%20N-acetylcysteine%20in%20stable%20COPD:%20the%201-year,%20double-blind,%20randomized,%20placebo-controlled%20HIACE%20study&amp;author=HN%20Tse&amp;author=L%20Raiteri&amp;author=KY%20Wong&amp;volume=144&amp;issue=1&amp;publication_year=2013&amp;pages=106-118&amp;pmid=23348146&amp;doi=10.1378\/chest.12-2357&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>29.&nbsp;\u90d1\u3001\u6e29\u3001FQ\u3001\u767dCX \u7b49\u3002\u6bcf\u65e5\u4e24\u6b21N-\u4e59\u9170\u534a\u80f1\u6c28\u9178600\u6beb\u514b\u7528\u4e8e\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u6076\u5316\uff08PANTHEON\uff09\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u3002Lancet Respir Med\u30022014; 2(3):187\u2013194. DOI\uff1a10.1016\/S2213-2600\uff0813\uff0970286-8\u3002[<a href=\"https:\/\/doi.org\/10.1016\/S2213-2600(13)70286-8\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24621680\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Lancet%20Respir%20Med&amp;title=Twice%20daily%20N-acetylcysteine%20600%20mg%20for%20exacerbations%20of%20chronic%20obstructive%20pulmonary%20disease%20(PANTHEON):%20a%20randomised,%20double-blind%20placebo-controlled%20trial&amp;author=JP%20Zheng&amp;author=FQ%20Wen&amp;author=CX%20Bai&amp;volume=2&amp;issue=3&amp;publication_year=2014&amp;pages=187-194&amp;pmid=24621680&amp;doi=10.1016\/S2213-2600(13)70286-8&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>30.&nbsp;Cazzola M\uff0c Calzetta L\uff0c Page C \u7b49\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9\u6162\u6027\u652f\u6c14\u7ba1\u708e\u6216\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u6025\u6027\u52a0\u91cd\u7684\u5f71\u54cd\uff1a\u835f\u8403\u5206\u6790\u3002\u300a\u6b27\u6d32\u547c\u5438\u7597\u6cd5\u8bc4\u8bba\u300b2015\u5e74; 24(137):451\u2013461. DOI\uff1a10.1183\/16000617.00002215\u3002[<a href=\"https:\/\/doi.org\/10.1183\/16000617.00002215\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9487680\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26324807\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20Respir%20Rev&amp;title=Influence%20of%20N-acetylcysteine%20on%20chronic%20bronchitis%20or%20COPD%20exacerbations:%20a%20meta-analysis&amp;author=M%20Cazzola&amp;author=L%20Calzetta&amp;author=C%20Page&amp;volume=24&amp;issue=137&amp;publication_year=2015&amp;pages=451-461&amp;pmid=26324807&amp;doi=10.1183\/16000617.00002215&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>31.&nbsp;\u6c88Y\u3001\u8521\u5b87\u3001\u96f7S\u3001\u5f20\u5fd7\u3002\u9ad8\u4f4e\u5242\u91cfN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u7684\u5f71\u54cd\uff1a\u7cfb\u7edf\u7efc\u8ff0\u4e0e\u835f\u8403\u5206\u6790\u3002COPD\u3002 2014; 11(3):351\u2013358. DOI\uff1a10.3109\/15412555.2013.858315\u3002[<a href=\"https:\/\/doi.org\/10.3109\/15412555.2013.858315\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24378052\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=COPD&amp;title=Effect%20of%20high\/low%20dose%20N-acetylcysteine%20on%20chronic%20obstructive%20pulmonary%20disease:%20a%20systematic%20review%20and%20meta-analysis&amp;author=Y%20Shen&amp;author=W%20Cai&amp;author=S%20Lei&amp;author=Z%20Zhang&amp;volume=11&amp;issue=3&amp;publication_year=2014&amp;pages=351-358&amp;pmid=24378052&amp;doi=10.3109\/15412555.2013.858315&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>32.&nbsp;\u970d\u5c14\u8fea\u5c3c\u65af\u5148\u751f\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u4e34\u5e8a\u836f\u4ee3\u52a8\u529b\u5b66\u3002\u514b\u6797\u836f\u7269\u52a8\u529b\u5b66\u3002 1991; 20(2):123\u2013134. DOI\uff1a10.2165\/00003088-199120020-00004\u3002<a href=\"https:\/\/doi.org\/10.2165\/00003088-199120020-00004\">[DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2029805\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Clin%20Pharmacokinet&amp;title=Clinical%20pharmacokinetics%20of%20N-acetylcysteine&amp;author=MR%20Holdiness&amp;volume=20&amp;issue=2&amp;publication_year=1991&amp;pages=123-134&amp;pmid=2029805&amp;doi=10.2165\/00003088-199120020-00004&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>33.&nbsp;Papi A\uff0c Di Stefano AFD\uff0c Radicioni M. \u5065\u5eb7\u4e2d\u56fd\u548c\u767d\u4eba\u5fd7\u613f\u8005\u53e3\u670dN-\u4e59\u9170\u534a\u6c28\u9178\u5355\u5242\u91cf\u548c\u591a\u6b21\u5242\u91cf\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u4e0e\u5b89\u5168\u6027\uff1a\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u4e00\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u9ad8\u7ea7\u4e34\u5e8a\u7814\u7a76\u3002 2021; 38(1):468\u2013478. DOI\uff1a10.1007\/s12325-020-01542-4\u3002[<a href=\"https:\/\/doi.org\/10.1007\/s12325-020-01542-4\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7854405\/\">\u975ePMC\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33146843\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Adv%20Ther&amp;title=Pharmacokinetics%20and%20safety%20of%20single%20and%20multiple%20doses%20of%20oral%20n-acetylcysteine%20in%20healthy%20Chinese%20and%20Caucasian%20volunteers:%20an%20open-label,%20phase%20I%20clinical%20study&amp;author=A%20Papi&amp;author=AFD%20Di%20Stefano&amp;author=M%20Radicioni&amp;volume=38&amp;issue=1&amp;publication_year=2021&amp;pages=468-478&amp;pmid=33146843&amp;doi=10.1007\/s12325-020-01542-4&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>34.&nbsp;Olsson B\uff0c Johansson M\uff0c Gabrielsson J\uff0c Bolme P. \u8fd8\u539f\u548c\u6c27\u5316N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u4e0e\u751f\u7269\u5229\u7528\u5ea6\u3002\u6b27\u514b\u6797\u836f\u79d1\u5c14\u6742\u5fd7\u30021988;34(1):77\u201382.DOI\uff1a10.1007\/BF01061422\u3002[<a href=\"https:\/\/doi.org\/10.1007\/BF01061422\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3360052\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20J%20Clin%20Pharmacol&amp;title=Pharmacokinetics%20and%20bioavailability%20of%20reduced%20and%20oxidized%20N-acetylcysteine&amp;author=B%20Olsson&amp;author=M%20Johansson&amp;author=J%20Gabrielsson&amp;author=P%20Bolme&amp;volume=34&amp;issue=1&amp;publication_year=1988&amp;pages=77-82&amp;pmid=3360052&amp;doi=10.1007\/BF01061422&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>35.&nbsp;Borgstr\u00f6m L\uff0c K\u00e5gedal B\uff0c Paulsen O. \u4eba\u4f53N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3002Eur J 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href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18635433\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=N%20Engl%20J%20Med&amp;title=Acetylcysteine%20for%20acetaminophen%20poisoning&amp;author=KJ%20Heard&amp;volume=359&amp;issue=3&amp;publication_year=2008&amp;pages=285-292&amp;pmid=18635433&amp;doi=10.1056\/NEJMct0708278&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>37.&nbsp;Bonanomi L\uff0c Gazzaniga A. \u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u6bd2\u7406\u5b66\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u4ee3\u8c22\u7814\u7a76\u3002\u300a\u6b27\u6d32\u8bc4\u8bba\u6742\u5fd7\u300b\u7eed\u7f16\uff0c1980\u5e74;111\uff1a45\u201351\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6938410\/\">PubMed<\/a>][<a 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href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Aust%20Prescr&amp;title=Paediatric%20pharmacokinetics%20and%20drug%20doses&amp;author=K%20O%E2%80%99Hara&amp;volume=39&amp;issue=6&amp;publication_year=2016&amp;pages=208-210&amp;pmid=27990048&amp;doi=10.18773\/austprescr.2016.071&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>40.&nbsp;Santus P\uff0c Signorello JC\uff0c Danzo F\uff0c Lazzaroni G\uff0c Saad M\uff0c Radovanovic D. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u6297\u708e\u548c\u6297\u6c27\u5316\u7279\u6027\uff1a\u65b0\u89c6\u89d2\u3002J Clin Med. 2024;13(14):4127.DOI\uff1a10.3390\/JCM13144127\u3002[<a href=\"https:\/\/doi.org\/10.3390\/jcm13144127\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11278452\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39064168\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Clin%20Med&amp;title=Anti-inflammatory%20and%20anti-oxidant%20properties%20of%20n-acetylcysteine:%20a%20fresh%20perspective&amp;author=P%20Santus&amp;author=JC%20Signorello&amp;author=F%20Danzo&amp;author=G%20Lazzaroni&amp;author=M%20Saad&amp;volume=13&amp;issue=14&amp;publication_year=2024&amp;pages=4127&amp;pmid=39064168&amp;doi=10.3390\/jcm13144127&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>41.&nbsp;Aldini G\u3001Altomare A\u3001Baron G \u7b49\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u4f5c\u4e3a\u6297\u6c27\u5316\u5242\u548c\u4e8c\u786b\u5316\u7269\u7834\u574f\u5242\uff1a\u539f\u56e0\u3002\u81ea\u7531\u57fa\u7814\u7a76\uff0c2018\u5e74;52(7):751\u2013762.DOI\uff1a10.1080\/10715762.2018.1468564\u3002[<a href=\"https:\/\/doi.org\/10.1080\/10715762.2018.1468564\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29742938\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Free%20Radic%20Res&amp;title=N-Acetylcysteine%20as%20an%20antioxidant%20and%20disulphide%20breaking%20agent:%20the%20reasons%20why&amp;author=G%20Aldini&amp;author=A%20Altomare&amp;author=G%20Baron&amp;volume=52&amp;issue=7&amp;publication_year=2018&amp;pages=751-762&amp;pmid=29742938&amp;doi=10.1080\/10715762.2018.1468564&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>42.&nbsp;\u963f\u9c81\u5965\u9a6c OI\uff0c\u54c8\u5229\u97e6\u5c14 B\uff0c\u970d\u4f0a BM\uff0c\u5df4\u7279\u52d2 J.N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u6297\u6c27\u5316\u4f5c\u7528\uff1a\u5176\u4e0e\u8fc7\u6c27\u5316\u6c22\u3001\u7f9f\u57fa\u81ea\u7531\u57fa\u3001\u8fc7\u6c27\u5316\u7269\u548c\u6b21\u6c2f\u9178\u7684\u53cd\u5e94\u3002\u81ea\u7531\u653e\u5c04\u6027\u751f\u7269\u5b66\u533b\u5b66\uff0c1989\u5e74;6(6):593\u2013597.DOI\uff1a10.1016\/0891-5849\uff0889\uff0990066-X\u3002[<a href=\"https:\/\/doi.org\/10.1016\/0891-5849(89)90066-x\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2546864\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Free%20Radic%20Biol%20Med&amp;title=The%20antioxidant%20action%20of%20N-acetylcysteine:%20its%20reaction%20with%20hydrogen%20peroxide,%20hydroxyl%20radical,%20superoxide,%20and%20hypochlorous%20acid&amp;author=OI%20Aruoma&amp;author=B%20Halliwell&amp;author=BM%20Hoey&amp;author=J%20Butler&amp;volume=6&amp;issue=6&amp;publication_year=1989&amp;pages=593-597&amp;pmid=2546864&amp;doi=10.1016\/0891-5849(89)90066-x&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>43.&nbsp;Santus P\uff0c Corsico A\uff0c Solidoro P\uff0c Braido F\uff0c Di Marco F\uff0c Scichilone N. \u6c27\u5316\u5e94\u6fc0\u4e0e\u547c\u5438\u7cfb\u7edf\uff1aN-\u4e59\u9170\u534a\u6c28\u9178\u7684\u836f\u7406\u5b66\u548c\u4e34\u5e8a\u518d\u8bc4\u4f30\u3002\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\uff08COPD\uff09\u30022014;11(6):705\u2013717.DOI\uff1a10.3109\/15412555.2014.898040\u3002[<a href=\"https:\/\/doi.org\/10.3109\/15412555.2014.898040\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4245155\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24787454\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=COPD&amp;title=Oxidative%20stress%20and%20respiratory%20system:%20pharmacological%20and%20clinical%20reappraisal%20of%20N-acetylcysteine&amp;author=P%20Santus&amp;author=A%20Corsico&amp;author=P%20Solidoro&amp;author=F%20Braido&amp;author=F%20Di%20Marco&amp;volume=11&amp;issue=6&amp;publication_year=2014&amp;pages=705-717&amp;pmid=24787454&amp;doi=10.3109\/15412555.2014.898040&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>44.&nbsp;Zhitkovich A. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\uff1a\u6297\u6c27\u5316\u5242\u3001\u919b\u7c7b\u6e05\u9664\u5242\u7b49\u3002\u5316\u5b66\u53cd\u5e94\u7c7b\u6bd2\u7d20\u30022019;32(7):1318\u20131319.DOI\uff1a10.1021\/acs.chemrestox.9b00152\u3002[<a href=\"https:\/\/doi.org\/10.1021\/acs.chemrestox.9b00152\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6757335\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31046246\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chem%20Res%20Toxicol&amp;title=N-acetylcysteine:%20antioxidant,%20aldehyde%20scavenger,%20and%20more&amp;author=A%20Zhitkovich&amp;volume=32&amp;issue=7&amp;publication_year=2019&amp;pages=1318-1319&amp;pmid=31046246&amp;doi=10.1021\/acs.chemrestox.9b00152&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>45.&nbsp;\u8428\u7a46\u5c3c\u00b7Y\uff0c\u6208\u5fb7\u65af\u5766\u00b7S\uff0c\u8fea\u6069\u00b7OM\uff0c\u5e03\u96f7\u514b\u00b7M\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u5316\u5b66\u548c\u751f\u7269\u6d3b\u6027\u3002\u751f\u7269\u7269\u7406\u5b66\u62a5\u30022013;1830(8):4117\u20134129.DOI\uff1a10.1016\/j.bbagen.2013.04.016\u3002[<a href=\"https:\/\/doi.org\/10.1016\/j.bbagen.2013.04.016\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23618697\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Biochim%20Biophys%20Acta&amp;title=The%20chemistry%20and%20biological%20activities%20of%20N-acetylcysteine&amp;author=Y%20Samuni&amp;author=S%20Goldstein&amp;author=OM%20Dean&amp;author=M%20Brek&amp;volume=1830&amp;issue=8&amp;publication_year=2013&amp;pages=4117-4129&amp;pmid=23618697&amp;doi=10.1016\/j.bbagen.2013.04.016&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>46.&nbsp;Lu SC. \u8c37\u80f1\u7518\u80bd\u5408\u6210\u3002\u751f\u7269\u7269\u7406\u5b66\u62a5\u603b\u5b50\u7248 2013;1830(5):3143\u20133153.DOI\uff1a10.1016\/j.bbagen.2012.09.008\u3002[<a href=\"https:\/\/doi.org\/10.1016\/j.bbagen.2012.09.008\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3549305\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22995213\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Biochim%20Biophys%20Acta%20Gen%20Subj&amp;title=Glutathione%20synthesis&amp;author=SC%20Lu&amp;volume=1830&amp;issue=5&amp;publication_year=2013&amp;pages=3143-3153&amp;pmid=22995213&amp;doi=10.1016\/j.bbagen.2012.09.008&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>47.&nbsp;Deponte M. \u8c37\u80f1\u7518\u80bd\u50ac\u5316\u53ca\u8c37\u80f1\u7518\u80bd\u4f9d\u8d56\u6027\u9176\u7684\u53cd\u5e94\u673a\u5236\u3002\u751f\u7269\u7269\u7406\u5b66\u62a5\u30022013;1830(5):3217\u20133266.DOI\uff1a10.1016\/j.bbagen.2012.09.018\u3002[<a href=\"https:\/\/doi.org\/10.1016\/j.bbagen.2012.09.018\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23036594\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Biochim%20Biophys%20Acta&amp;title=Glutathione%20catalysis%20and%20the%20reaction%20mechanisms%20of%20glutathione-dependent%20enzymes&amp;author=M%20Deponte&amp;volume=1830&amp;issue=5&amp;publication_year=2013&amp;pages=3217-3266&amp;pmid=23036594&amp;doi=10.1016\/j.bbagen.2012.09.018&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>48.&nbsp;Drost E\uff0c Skwarski K\uff0c Sauleda J \u7b49\u3002\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u4e25\u91cd\u6025\u6027\u52a0\u91cd\u4e2d\u7684\u6c27\u5316\u5e94\u6fc0\u548c\u6c14\u9053\u708e\u75c7\u3002\u80f8\u90e8\u30022005;60(4):293\u2013300.DOI\uff1a10.1136\/THX.2004.027946\u3002[<a href=\"https:\/\/doi.org\/10.1136\/thx.2004.027946\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1747355\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15790984\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Thorax&amp;title=Oxidative%20stress%20and%20airway%20inflammation%20in%20severe%20exacerbations%20of%20COPD&amp;author=E%20Drost&amp;author=K%20Skwarski&amp;author=J%20Sauleda&amp;volume=60&amp;issue=4&amp;publication_year=2005&amp;pages=293-300&amp;pmid=15790984&amp;doi=10.1136\/thx.2004.027946&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>49.&nbsp;Matera MG\uff0c Calzetta L\uff0c Cazzola M. \u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u4e2d\u7684\u6c27\u5316\u9014\u5f84\u4e0e\u52a0\u91cd\uff1aNAC\u7684\u4f5c\u7528\u30022016\u5e74\u83b7\u8bc4\u4e3a\u4e13\u5bb6\u96f7\u65af\u76ae\u5c14\u533b\u5b66\u9662\u7267\u5e08;10(1):89\u201397.DOI\uff1a10.1586\/17476348.2016.1121105\u3002[<a href=\"https:\/\/doi.org\/10.1586\/17476348.2016.1121105\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26567752\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Expert%20Rev%20Respir%20Med&amp;title=Oxidation%20pathway%20and%20exacerbations%20in%20COPD:%20the%20role%20of%20NAC&amp;author=MG%20Matera&amp;author=L%20Calzetta&amp;author=M%20Cazzola&amp;volume=10&amp;issue=1&amp;publication_year=2016&amp;pages=89-97&amp;pmid=26567752&amp;doi=10.1586\/17476348.2016.1121105&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>50.&nbsp;Altomare A\uff0c Baron G\uff0c Brioschi M \u7b49\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u901a\u8fc7\u786b\u9187-\u4e8c\u786b\u952e\u65ad\u88c2\u673a\u5236\u518d\u751f\u767d\u86cb\u767dCys34\uff1a\u89e3\u91ca\u5176\u80de\u5916\u6297\u6c27\u5316\u6d3b\u6027\u3002\u6297\u6c27\u5316\u5242\u30022020;9(5):367.DOI\uff1a10.3390\/antiox9050367\u3002[<a href=\"https:\/\/doi.org\/10.3390\/antiox9050367\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7278672\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32354002\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Antioxidants&amp;title=N-acetyl-cysteine%20regenerates%20albumin%20Cys34%20by%20a%20thiol-disulfide%20breaking%20mechanism:%20an%20explanation%20of%20its%20extracellular%20antioxidant%20activity&amp;author=A%20Altomare&amp;author=G%20Baron&amp;author=M%20Brioschi&amp;volume=9&amp;issue=5&amp;publication_year=2020&amp;pages=367&amp;pmid=32354002&amp;doi=10.3390\/antiox9050367&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>51.\u4f69\u5fb7\u96f7\u00b7B\uff0c\u5df4\u62c9\u5c24\u00b7U\uff0c\u57c3\u6cfd\u91cc\u5c3c\u4e9a\u00b7D\uff0c\u8fea\u514b\u00b7TP\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\uff08NAC\uff09\u7684\u4f5c\u7528\u673a\u5236\uff1aH2S\u548c\u786b\u78fa\u7c7b\u65b0\u5174\u4f5c\u7528\u3002\u836f\u7406\u5b66\u4e0e\u6cbb\u7597\u5b66\u30022021;228:107916.DOI\uff1a10.1016\/J.Pharmthera.2021.107916\u3002[<a href=\"https:\/\/doi.org\/10.1016\/j.pharmthera.2021.107916\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34171332\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Pharmacology%20&amp;%20Therapeutics&amp;title=The%20mechanism%20of%20action%20of%20N-acetylcysteine%20(NAC):%20the%20emerging%20role%20of%20H2S%20and%20sulfane%20sulfur%20species&amp;author=B%20Pedre&amp;author=U%20Barayeu&amp;author=D%20Ezeri%C5%86a&amp;author=TP%20Dick&amp;volume=228&amp;publication_year=2021&amp;pages=107916&amp;pmid=34171332&amp;doi=10.1016\/j.pharmthera.2021.107916&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>52.&nbsp;La Maestra S\uff0c De Flora S\uff0c Balansky R. \u6297\u6c27\u5316\u5242\u4e0eCOVID-19\u3002J Prev Med Hyg.2021;62\uff081 Suppl 3\uff09\uff1aE34\u2013E45\u3002DOI\uff1a10.15167\/2421-4248\/JPMH2021.62.1S3.1895\u3002[<a href=\"https:\/\/doi.org\/10.15167\/2421-4248\/jpmh2021.62.1S3.1895\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8452284\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34622082\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Prev%20Med%20Hyg&amp;title=Antioxidants%20and%20COVID-19&amp;author=S%20La%20Maestra&amp;author=S%20De%20Flora&amp;author=R%20Balansky&amp;volume=62&amp;issue=1%20Suppl%203&amp;publication_year=2021&amp;pages=E34-E45&amp;pmid=34622082&amp;doi=10.15167\/2421-4248\/jpmh2021.62.1S3.1895&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>53.&nbsp;\u5361\u4f50\u62c9 M\uff0c\u5361\u5c14\u6cfd\u5854 L\uff0c\u6cd5\u4e54\u6d1b F\uff0c\u7f57\u5229\u4e9a\u5c3c P\uff0c\u9a6c\u7279\u62c9 MG\u3002\u5173\u4e8eN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728COPD\u52a0\u91cd\u4f53\u5185\u6a21\u578b\u4e2d\u7684\u6297\u6c27\u5316\u548c\u6297\u708e\u6d3b\u6027\u7684\u836f\u7406\u5b66\u7814\u7a76\u3002Respir Res. 2017;18(1):26.DOI\uff1a10.1186\/S12931-016-0500-Y\u3002[<a href=\"https:\/\/doi.org\/10.1186\/s12931-016-0500-y\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5260037\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28118826\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Respir%20Res&amp;title=Pharmacological%20investigation%20on%20the%20anti-oxidant%20and%20anti-inflammatory%20activity%20of%20N-acetylcysteine%20in%20an%20ex%20vivo%20model%20of%20COPD%20exacerbation&amp;author=M%20Cazzola&amp;author=L%20Calzetta&amp;author=F%20Facciolo&amp;author=P%20Rogliani&amp;author=MG%20Matera&amp;volume=18&amp;issue=1&amp;publication_year=2017&amp;pages=26&amp;pmid=28118826&amp;doi=10.1186\/s12931-016-0500-y&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>54.&nbsp;Calzetta L\uff0c Rogliani P\uff0c Facciolo F\uff0c Rinaldi B\uff0c Cazzola M\uff0c Matera MG. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u901a\u8fc7\u8c03\u8282\u795e\u7ecf\u6fc0\u80bdA\u7684\u91ca\u653e\uff0c\u4fdd\u62a4\u4eba\u7c7b\u652f\u6c14\u7ba1\uff0c\u5f62\u6210COPD\u52a0\u91cd\u7684\u4f53\u5916\u6a21\u578b\u3002\u751f\u7269\u533b\u5b66\u836f\u5242\u5e08\u30022018;103:1\u20138.DOI\uff1a10.1016\/J.BioPHA.2018.04.011\u3002[<a href=\"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.011\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29635121\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Biomed%20Pharmacother&amp;title=N-acetylcysteine%20protects%20human%20bronchi%20by%20modulating%20the%20release%20of%20neurokinin%20A%20in%20an%20ex%20vivo%20model%20of%20COPD%20exacerbation&amp;author=L%20Calzetta&amp;author=P%20Rogliani&amp;author=F%20Facciolo&amp;author=B%20Rinaldi&amp;author=M%20Cazzola&amp;volume=103&amp;publication_year=2018&amp;pages=1-8&amp;pmid=29635121&amp;doi=10.1016\/j.biopha.2018.04.011&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>55.&nbsp;Cutrera R\uff0c Baraldi E\uff0c Indinnimeo L \u7b49\u3002\u513f\u79d1\u6025\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u7ba1\u7406\uff1a\u53e3\u670d\u76ae\u8d28\u7c7b\u56fa\u9187\u7684\u4f5c\u7528\u3002\u610f\u5927\u5229\u513f\u5b66\u6742\u5fd7\u30022017;43(1):31.DOI\uff1a10.1186\/S13052-017-0348-X\u3002[<a href=\"https:\/\/doi.org\/10.1186\/s13052-017-0348-x\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5364577\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28335827\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Italian%20J%20Pediatr&amp;title=Management%20of%20acute%20respiratory%20diseases%20in%20the%20pediatric%20population:%20the%20role%20of%20oral%20corticosteroids&amp;author=R%20Cutrera&amp;author=E%20Baraldi&amp;author=L%20Indinnimeo&amp;volume=43&amp;issue=1&amp;publication_year=2017&amp;pages=31&amp;pmid=28335827&amp;doi=10.1186\/s13052-017-0348-x&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>56.&nbsp;\u83ab\u91cc\u91c7AH\u3001\u4e30\u5854\u7eb3GA\u3001\u7d22\u7ef4\u4e9a\u5c14\u7ef4ARA\u7b49\u3002\u6162\u6027\u54b3\u55fd\u7684\u8bca\u65ad\u4e0e\u7ba1\u7406\u3002\u6b27\u6d32\u7814\u7a76\u6742\u5fd7 2004;24(3):481\u2013492.DOI\uff1a10.1183\/09031936.04.00027804\u3002[<a href=\"https:\/\/doi.org\/10.1183\/09031936.04.00027804\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15358710\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20Respir%20J&amp;title=The%20diagnosis%20and%20management%20of%20chronic%20cough&amp;author=AH%20Morice&amp;author=GA%20Fontana&amp;author=ARA%20Sovijarvi&amp;volume=24&amp;issue=3&amp;publication_year=2004&amp;pages=481-492&amp;pmid=15358710&amp;doi=10.1183\/09031936.04.00027804&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>57.&nbsp;\u6d77\u4f0aAD\uff0c\u5a01\u5c14\u900aAD\u30020\u81f34\u5c81\u513f\u7ae5\u521d\u7ea7\u62a4\u7406\u6025\u6027\u54b3\u55fd\u7684\u81ea\u7136\u75c5\u7a0b\uff1a\u7cfb\u7edf\u6027\u7efc\u8ff0\u3002\u666e\u901a\u5b9e\u4e60\u5f8b\u5e08\u534f\u4f1a\u30022002;52\uff08478\uff09\uff1a401\u2013409\u3002[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1314298\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12014540\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Br%20J%20Gen%20Pract&amp;title=The%20natural%20history%20of%20acute%20cough%20in%20children%20aged%200%20to%204%20years%20in%20primary%20care:%20a%20systematic%20review&amp;author=AD%20Hay&amp;author=AD%20Wilson&amp;volume=52&amp;issue=478&amp;publication_year=2002&amp;pages=401-409&amp;pmid=12014540&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>58.\u7f57\u6770\u65afDF\u3002\u80ba\u9ecf\u6db2\uff1a\u513f\u79d1\u89c6\u89d2\u3002\u513f\u79d1\u80ba\u52a8\u8109\u7624\u30022003;36(3):178\u2013188.\u6570\u636e\u6765\u6e90\uff1a10.1002\/ppul.10322\u3002[<a href=\"https:\/\/doi.org\/10.1002\/ppul.10322\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12910578\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Pediatr%20Pulmonol&amp;title=Pulmonary%20mucus:%20pediatric%20perspective&amp;author=DF%20Rogers&amp;volume=36&amp;issue=3&amp;publication_year=2003&amp;pages=178-188&amp;pmid=12910578&amp;doi=10.1002\/ppul.10322&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>59.&nbsp;Linssen RSN\uff0c \u9a6c J\uff0c Bem RA\uff0c Rubin BK. \u5408\u7406\u4f7f\u7528\u9ecf\u6db2\u6d3b\u6027\u836f\u7269\u6cbb\u7597\u513f\u7ae5\u6c14\u9053\u75be\u75c5\u30022020\u5e74\u300a\u513f\u79d1\u533b\u5e08\u62a5\u544a\u300b;36:8\u201314.DOI\uff1a 10.1016\/J.PRRV.2020.06.007.[<a href=\"https:\/\/doi.org\/10.1016\/j.prrv.2020.06.007\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7297155\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32653467\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Paediatr%20Respir%20Rev&amp;title=Rational%20use%20of%20mucoactive%20medications%20to%20treat%20pediatric%20airway%20disease&amp;author=RSN%20Linssen&amp;author=J%20Ma&amp;author=RA%20Bem&amp;author=BK%20Rubin&amp;volume=36&amp;publication_year=2020&amp;pages=8-14&amp;pmid=32653467&amp;doi=10.1016\/j.prrv.2020.06.007&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>60.&nbsp;\u7ef4\u8d3e\u4e9a\u5357\u5766\u00b7A\uff0c\u7eb3\u74e6\u7ef4\u00b7O\u3002\u826f\u597d\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357\u7684\u91cd\u8981\u6027\u53ca\u5176\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u4f5c\u7528\u3002\u751f\u7269\u533b\u5b66\u5f71\u50cf\u56fd\u9645\u6742\u5fd7\uff0c2008\u5e74;4\uff081\uff09\uff1ae5\u3002DOI\uff1a10.2349\/biij.4.1.e5\u3002[<a href=\"https:\/\/doi.org\/10.2349\/biij.4.1.e5\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3097692\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21614316\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Biomed%20Imaging%20Interv%20J&amp;title=The%20importance%20of%20Good%20Clinical%20Practice%20guidelines%20and%20its%20role%20in%20clinical%20trials&amp;author=A%20Vijayananthan&amp;author=O%20Nawawi&amp;volume=4&amp;issue=1&amp;publication_year=2008&amp;pages=e5&amp;pmid=21614316&amp;doi=10.2349\/biij.4.1.e5&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>61.&nbsp;\u83f2\u5965\u5947\u00b7A\uff0c\u7ef4\u5c3c\u4e9a\u8482\u00b7B\uff0c\u8428\u62c9\u00b7M\u7b49\u3002\u513f\u7ae5\u6025\u6027\u652f\u6c14\u7ba1\u80ba\u708e\u4e2d\u7684\u65b0\u578bN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5236\u5242\u3002\u610f\u5927\u5229\u5c0f\u9a6c\u62c9\u8482\u00b7\u5fb7\u5c14\u00b7\u6258\u62c9\u65af\u30021989;43\uff084\uff09\uff1a327\u2013334\u3002[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Giornale%20Italiano%20Delle%20Malattie%20del%20Torace&amp;title=A%20new%20N-acetylcysteine%20formulation%20in%20acute%20bronchopneumopathy%20in%20children&amp;author=A%20Fiocchi&amp;author=B%20Vignati&amp;author=M%20Sala&amp;volume=43&amp;issue=4&amp;publication_year=1989&amp;pages=327-334&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>62.&nbsp;Chalumeau M\uff0cDuijvestijn \u9752\u5e74\u56e2\u3002\u4e59\u9170\u534a\u80f1\u6c28\u9178\u548c\u78b3\u534a\u80f1\u6c28\u9178\u7528\u4e8e\u65e0\u6162\u6027\u652f\u6c14\u7ba1\u80ba\u75be\u75c5\u513f\u7ae5\u7684\u6025\u6027\u4e0a\u547c\u5438\u9053\u548c\u4e0b\u547c\u5438\u9053\u611f\u67d3\u3002Cochrane\u6570\u636e\u5e93\u7cfb\u7edf\u8bc4\u8bba 2013;2013\uff085\uff09\uff1aCD003124\u3002DOI\uff1a10.1002\/14651858.CD003124.pub4\u3002[<a href=\"https:\/\/doi.org\/10.1002\/14651858.CD003124.pub4\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11285305\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23728642\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cochrane%20Database%20Syst%20Rev&amp;title=Acetylcysteine%20and%20carbocysteine%20for%20acute%20upper%20and%20lower%20respiratory%20tract%20infections%20in%20paediatric%20patients%20without%20chronic%20broncho-pulmonary%20disease&amp;author=M%20Chalumeau&amp;author=YCM%20Duijvestijn&amp;volume=2013&amp;issue=5&amp;publication_year=2013&amp;pages=CD003124&amp;pmid=23728642&amp;doi=10.1002\/14651858.CD003124.pub4&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>63.&nbsp;Hashemian H\uff0c Qobadighadikolaei R\uff0c Seifnezhad P \u7b49\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u4e2d\u5ea6COVID-19\u513f\u7ae5\u4e2d\u7684\u7597\u6548\uff1a\u5b89\u6170\u5242\u5bf9\u7167\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8ba1\u7b97\u673a\u6559\u80b2\u6742\u5fd7\u30022024;15\uff082\uff09\uff1ae139612\u3002DOI\uff1a10.5812\/JCP-139612\u3002[<a href=\"https:\/\/doi.org\/10.5812\/jcp-139612\">DOI<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Compr%20Ped&amp;title=Efficacy%20of%20N-acetylcysteine%20in%20children%20with%20moderate%20COVID-19:%20a%20placebo-controlled%20randomized%20clinical%20trial&amp;author=H%20Hashemian&amp;author=R%20Qobadighadikolaei&amp;author=P%20Seifnezhad&amp;volume=15&amp;issue=2&amp;publication_year=2024&amp;pages=e139612&amp;doi=10.5812\/jcp-139612&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>64.&nbsp;Trastotenojo MS\u3001Harsoyo N\u3001Sachro AD \u7b49\u3002\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u513f\u7ae5\u547c\u5438\u9053\u75be\u75c5\u4e2d\u7684\u5e94\u7528\u3002\u513f\u7ae5\u56e0\u591a\u5185\u65af\u30021984;24\uff081\u20132\uff09\uff1a1\u201310\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6382125\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Paediatr%20Indones&amp;title=Use%20of%20acetyl%20cysteine%20in%20respiratory%20tract%20disease%20in%20children&amp;author=MS%20Trastotenojo&amp;author=N%20Harsoyo&amp;author=AD%20Sachro&amp;volume=24&amp;issue=1%E2%80%932&amp;publication_year=1984&amp;pages=1-10&amp;pmid=6382125&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>65.&nbsp;Bellomo G\uff0c Giudice S\uff0c Ganci C. [\u5173\u4e8e\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u513f\u79d1\u6025\u6027\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u53e3\u670d\u548c\u808c\u8089\u6ce8\u5c04\u7597\u6548\u7684\u6bd4\u8f83\u7814\u7a76]\u3002Minerva\u513f\u79d1\u533b\u751f\u30021973;25\uff0819\uff09\uff1a844\u2013849\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/4581630\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Minerva%20Pediatr&amp;author=G%20Bellomo&amp;author=S%20Giudice&amp;author=C%20Ganci&amp;volume=25&amp;issue=19&amp;publication_year=1973&amp;pages=844-849&amp;pmid=4581630&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>66. Camurri&nbsp;S\uff0c Marenco G. \u6eb4\u5df1\u5b9a\u65b0\u5236\u5242\u5728\u6025\u6027\u652f\u6c14\u7ba1\u708e\u513f\u79d1\u60a3\u8005\u4e2d\u5b89\u5168\u6027\u548c\u7597\u6548\u7684\u4e34\u5e8a\u8bc4\u4f30\uff0c\u6bd4\u8f83N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u3002[\u65b0\u578b\u836f\u7269\u914d\u65b9\u6eb4\u7f8e\u8f9b\u9897\u7c92\u5728\u5c0f\u578b\u6025\u6027\u652f\u6c14\u7ba1\u708e\u60a3\u8005\u4e2d\u76f8\u8f83\u9897\u7c92\u6027N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u7597\u6548\u548c\u8010\u53d7\u6027\u4e34\u5e8a\u8bc4\u4f30]\u3002\u610f\u5927\u5229\u533b\u5b66\u516c\u62a5\u30021990;149\uff1a45\u201348\u3002[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Gazzetta%20Medica%20Italiana&amp;title=Clinical%20evaluation%20of%20the%20safety%20and%20efficacy%20of%20a%20new%20pharmaceutical%20formulation%20of%20bromhexine%20compared%20to%20N-acetylcysteine%20in%20pediatric%20patients%20with%20acute%20bronchitis&amp;author=S%20Camurri&amp;author=G%20Marenco&amp;volume=149&amp;publication_year=1990&amp;pages=45-48&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>67.&nbsp;\u9648\u5fd7\u3001\u6731\u6bc5\u3001\u90d1C\u3001\u8d75\u5b87\u3001\u5218\u542f\u3002\u5e03\u5730\u5948\u5fb7\u4e0e\u4e59\u9170\u534a\u6c28\u9178\u8054\u5408\u6cbb\u7597\u652f\u539f\u4f53\u80ba\u708e\u611f\u67d3\u7684\u4e34\u5e8a\u7597\u6548\u3002\u514d\u75ab\u708e\u75c7\u7814\u7a76\uff0c2023\u5e74;11\uff0811\uff09\uff1ae1068\u3002\u6570\u636e\u6765\u6e90\uff1a10.1002\/IID3.1068\u3002[<a href=\"https:\/\/doi.org\/10.1002\/iid3.1068\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10664398\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38018572\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Immun%20Inflamm%20Dis&amp;title=Clinical%20efficacy%20of%20budesonide%20combined%20with%20acetylcysteine%20in%20the%20treatment%20of%20mycoplasma%20pneumonia%20infection&amp;author=J%20Chen&amp;author=Y%20Zhu&amp;author=C%20Zheng&amp;author=W%20Zhao&amp;author=Q%20Liu&amp;volume=11&amp;issue=11&amp;publication_year=2023&amp;pages=e1068&amp;pmid=38018572&amp;doi=10.1002\/iid3.1068&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>68.&nbsp;\u859bA\u3001\u5f20\u6d69\u3001\u5b8bS\u3001\u590f\u6bc5\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u8054\u5408\u76d0\u9178\u5b89\u5e03\u7f57\u7d22\u5bf9\u80ba\u708e\u513f\u7ae5\u4e34\u5e8a\u75c7\u72b6\u3001CRP\u548cPCT\u7684\u5f71\u54cd\u3002\u8bca\u6240\u30022024;79:100476.DOI\uff1a10.1016\/J.ClinSp.2024.100476\u3002[<a href=\"https:\/\/doi.org\/10.1016\/j.clinsp.2024.100476\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11399695\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39208656\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Clinics&amp;title=Effects%20of%20N-acetylcysteine%20combined%20with%20ambroxol%20hydrochloride%20on%20clinical%20symptoms,%20CRP,%20and%20PCT%20in%20children%20with%20pneumonia&amp;author=A%20Xue&amp;author=H%20Zhang&amp;author=S%20Song&amp;author=Y%20Xia&amp;volume=79&amp;publication_year=2024&amp;pages=100476&amp;pmid=39208656&amp;doi=10.1016\/j.clinsp.2024.100476&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>69.&nbsp;Seidita F\uff0c Deiana M\uff0c Careddu P. \u513f\u79d1\u6025\u6027\u652f\u6c14\u7ba1\u75be\u75c5\uff1a\u4f7f\u7528\u7d22\u5e03\u7f57\u5c14\u9897\u7c92\u7684\u6cbb\u7597\u65b9\u6cd5\u3002G Ital Mal Torace\u30021984;38\uff1a191\u2013194\u3002[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=G%20Ital%20Mal%20Torace&amp;title=Acute%20bronchial%20diseases%20in%20paediatrics:%20therapeutic%20approach%20with%20sobrerol%20granules&amp;author=F%20Seidita&amp;author=M%20Deiana&amp;author=P%20Careddu&amp;volume=38&amp;publication_year=1984&amp;pages=191-194&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>70.&nbsp;Varricchio A\uff0c Ciprandi G \u4e34\u5e8a\u547c\u5438\u9053\u611f\u67d3\u7ba1\u7406\u7814\u7a76\u7ec4\u3002Sobrerol \u5728\u201c\u5bd2\u51b7\u201d\u5b63\u8282\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u7ba1\u7406\u6025\u6027\u547c\u5438\u9053\u611f\u67d3\uff1a\u610f\u5927\u5229\u521d\u7ea7\u4fdd\u5065\u7ecf\u9a8c\u30022024\u5e74\u56fd\u9645\u666e\u901a\u533b\u5b66\u6742\u5fd7;17:5471\u20135477.doi\uff1a10.2147\/IJGM\u3002S497547\u3002[<a href=\"https:\/\/doi.org\/10.2147\/IJGM.S497547\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11602432\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39611003\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int%20J%20Gen%20Med&amp;title=Sobrerol%20in%20managing%20acute%20respiratory%20infections%20in%20clinical%20practice%20during%20the%20%E2%80%9Ccold%E2%80%9D%20season:%20an%20Italian%20primary%20care%20experience&amp;author=A%20Varricchio&amp;author=G%20Ciprandi&amp;volume=17&amp;publication_year=2024&amp;pages=5471-5477&amp;pmid=39611003&amp;doi=10.2147\/IJGM.S497547&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>71.&nbsp;\u5218\u6d69\u3001\u738b\u5b87\u3001\u9ad8\u65ed\u3002\u6bd4\u8f83\u76d0\u9178\u5b89\u5e03\u7f57\u6614\u548cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u6cbb\u7597\u652f\u6c14\u7ba1\u80ba\u708e\u513f\u7ae5\u4e2d\u7684\u7597\u6548\u53ca\u5176\u5bf9\u9884\u540e\u7684\u5f71\u54cd\u30022020\u5e74\u533b\u5b66\u5b9e\u4e60;20(6):130.DOI\uff1a10.3892\/ETM.2020.9260\u3002[<a href=\"https:\/\/doi.org\/10.3892\/etm.2020.9260\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7557708\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33082862\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Exp%20Ther%20Med&amp;title=Comparison%20of%20the%20efficacy%20of%20ambroxol%20hydrochloride%20and%20N-acetylcysteine%20in%20the%20treatment%20of%20children%20with%20bronchopneumonia%20and%20their%20influence%20on%20prognosis&amp;author=H%20Liu&amp;author=W%20Wang&amp;author=X%20Gao&amp;volume=20&amp;issue=6&amp;publication_year=2020&amp;pages=130&amp;pmid=33082862&amp;doi=10.3892\/etm.2020.9260&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>72.&nbsp;\u7c73\u5207\u5c14 EA\uff0c\u57c3\u5229\u5965\u7279 \u8dd1\u536b\u3002\u53e3\u670dN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u56ca\u6027\u7ea4\u7ef4\u5316\u4e2d\u7684\u5bf9\u7167\u8bd5\u9a8c\u3002\u6fb3\u5927\u5229\u4e9a\u513f\u79d1\u533b\u5e08J. 1982;18(1):40\u201342.DOI\uff1a10.1111\/J.1440-1754.1982.TB01978.X\u3002[<a href=\"https:\/\/doi.org\/10.1111\/j.1440-1754.1982.tb01978.x\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7049146\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Aust%20Paediatr%20J&amp;title=Controlled%20trial%20of%20oral%20N-acetylcysteine%20in%20cystic%20fibrosis&amp;author=EA%20Mitchell&amp;author=RB%20Elliott&amp;volume=18&amp;issue=1&amp;publication_year=1982&amp;pages=40-42&amp;pmid=7049146&amp;doi=10.1111\/j.1440-1754.1982.tb01978.x&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>73.&nbsp;\u65af\u5854\u51e1\u683c G\uff0c\u52a0\u5185 S\uff0c\u8c6a\u7ef4\u8328 P\uff0c\u83ab\u5361\u585e\u5c14 E\uff0c\u79d1\u8d6b C.\u56ca\u6027\u7ea4\u7ef4\u5316\u548c\u539f\u53d1\u6027\u776b\u6bdb\u8fd0\u52a8\u969c\u788d\u60a3\u8005\u53e3\u670dN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u4e34\u5e8a\u6548\u5e94\u53ca\u5bf9\u776b\u72b6\u4f53\u8fd0\u52a8\u7684\u5f71\u54cd\u3002\u300a\u6b27\u6d32\u590d\u82cf\u8005\u6742\u5fd7\u300b1988\u5e74;1\uff082\uff09\uff1a161\u2013167\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3282911\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20Respir%20J&amp;title=The%20clinical%20effect%20and%20the%20effect%20on%20the%20ciliary%20motility%20of%20oral%20N-acetylcysteine%20in%20patients%20with%20cystic%20fibrosis%20and%20primary%20ciliary%20dyskinesia&amp;author=G%20Stafanger&amp;author=S%20Garne&amp;author=P%20Howitz&amp;author=E%20Morkassel&amp;author=C%20Koch&amp;volume=1&amp;issue=2&amp;publication_year=1988&amp;pages=161-167&amp;pmid=3282911&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>74.&nbsp;Stafanger G\uff0c Koch C. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u56ca\u6027\u7ea4\u7ef4\u5316\u548c\u94dc\u7eff\u5047\u5355\u80de\u83cc\u611f\u67d3\u4e2d\u7684\u4e34\u5e8a\u8bc4\u5206\u3001\u80ba\u6d3b\u91cf\u548c\u776b\u72b6\u4f53\u8fd0\u52a8\u3002\u300a\u6b27\u6d32\u590d\u82cf\u6742\u5fd7\u300b1989\u5e74;2\uff083\uff09\uff1a234\u2013237\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2659383\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20Respir%20J&amp;title=N-acetylcysteine%20in%20cystic%20fibrosis%20and%20Pseudomonas%20aeruginosa%20infection:%20clinical%20score,%20spirometry%20and%20ciliary%20motility&amp;author=G%20Stafanger&amp;author=C%20Koch&amp;volume=2&amp;issue=3&amp;publication_year=1989&amp;pages=234-237&amp;pmid=2659383&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>75.&nbsp;\u62c9\u7279\u5ef6 F\uff0c\u6c83\u5185 R\uff0c\u6ce2\u585e\u5c14\u7279 \u4e2d\u573a\uff0c\u65af\u7279\u5f17 B\uff0c\u970d\u592b\u66fc D\uff0c\u672c\u5fb7 SW\u3002\u4e00\u9879\u53e3\u670d\u5b89\u5e03\u7f57\u7d22\u548cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7528\u4e8e\u56ca\u6027\u7ea4\u7ef4\u5316\u9ecf\u6db2\u6eb6\u89e3\u6cbb\u7597\u7684\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u3002\u300a\u6b27\u6d32\u513f\u79d1\u6742\u5fd7\u300b\u30021985;144(4):374\u2013378.DOI\uff1a10.1007\/BF00441781\u3002[<a href=\"https:\/\/doi.org\/10.1007\/BF00441781\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3908111\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20J%20Pediatr&amp;title=A%20double-blind%20placebo%20controlled%20trial%20with%20oral%20ambroxol%20and%20N-acetylcysteine%20for%20mucolytic%20treatment%20in%20cystic%20fibrosis&amp;author=F%20Ratjen&amp;author=R%20W%C3%B6nne&amp;author=HG%20Posselt&amp;author=B%20St%C3%B6ver&amp;author=D%20Hofmann&amp;volume=144&amp;issue=4&amp;publication_year=1985&amp;pages=374-378&amp;pmid=3908111&amp;doi=10.1007\/BF00441781&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>76.&nbsp;G\u00f6tz M\uff0c Kraemer R\uff0c Kerrebijn KF \u7b49\u3002\u56ca\u6027\u7ea4\u7ef4\u5316\u4e2d\u7684\u53e3\u670d\u4e59\u9170\u534a\u80f1\u6c28\u9178\u3002\u4e00\u9879\u5408\u4f5c\u7814\u7a76\u3002\u300a\u6b27\u6d32\u8bc4\u8bba\u6742\u5fd7\u300b\u7eed\u7f16\uff0c1980\u5e74;111\uff1a122\u2013126\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7011832\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20J%20Respir%20Dis%20Suppl&amp;title=Oral%20acetylcysteine%20in%20cystic%20fibrosis.%20A%20co-operative%20study&amp;author=M%20G%C3%B6tz&amp;author=R%20Kraemer&amp;author=KF%20Kerrebijn&amp;volume=111&amp;publication_year=1980&amp;pages=122-126&amp;pmid=7011832&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>77. Baran&nbsp;D. \u53e3\u670d\u4e59\u9170\u534a\u80f1\u6c28\u9178\u4e0e\u5b89\u6170\u5242\u5728\u56ca\u6027\u7ea4\u7ef4\u5316\u4e2d\u7684\u4e34\u5e8a\u53cc\u76f2\u8bd5\u9a8c\u3002\u6cbb\u7597\u5468\u30021980;30\uff1a2034\u20132039\u3002[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Therapiewoche&amp;title=Klinischer%20Doppelblinversuch%20mit%20oralen%20Acetylcystein%20und%20Placebo%20bei%20zystischer%20Fibrose&amp;author=D%20Baran&amp;volume=30&amp;publication_year=1980&amp;pages=2034-2039&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>78.&nbsp;Rudnik J\uff0c Gawel J\uff0c Haluszka J \u7b49\u3002\u6162\u6027\u80ba\u75c5\u513f\u7ae5\u53e3\u670d\u4e59\u9170\u534a\u80f1\u6c28\u9178\u6cbb\u7597\u3002\u300a\u6b27\u6d32\u8bc4\u8bba\u6742\u5fd7\u300b1980\u5e74;61\uff08111\uff09\uff1a140\u3002[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20J%20Respir%20Dis&amp;title=Oral%20acetylcysteine%20treatment%20in%20children%20with%20chronic%20lung%20diseases&amp;author=J%20Rudnik&amp;author=J%20Gawel&amp;author=J%20Haluszka&amp;volume=61&amp;issue=111&amp;publication_year=1980&amp;pages=140&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>79.&nbsp;Steil E\uff0c Niessen KH\u3002\u53e3\u670d\u4e59\u9170\u534a\u80f1\u6c28\u9178\u6cbb\u7597\u56ca\u6027\u7ea4\u7ef4\u5316\u513f\u7ae5\u7684\u547c\u6c14\u901a\u6c14\u5bb9\u91cf\u6d4b\u91cf\u3002\u300a\u6b27\u6d32\u8bc4\u8bba\u6742\u5fd7\u300b\u7eed\u7f16\uff0c1980\u5e74;111\uff1a132\u2013133\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6938398\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20J%20Respir%20Dis%20Suppl&amp;title=Expiratory%20ventilatory%20capacity%20measurements%20in%20children%20with%20cystic%20fibrosis%20treated%20by%20oral%20acetylcysteine&amp;author=E%20Steil&amp;author=KH%20Niessen&amp;volume=111&amp;publication_year=1980&amp;pages=132-133&amp;pmid=6938398&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>80.&nbsp;Baldini G\uff0c Gucci M\uff0c Tar\u00f2 D \u7b49\u4eba[\u4e00\u9879\u5173\u4e8e\u65b0\u578b\u5b89\u5e03\u7f57\u7d22\u5236\u5242\u5728\u513f\u7ae5\u54ee\u5598\u6837\u652f\u6c14\u7ba1\u708e\u4e2d\u4f5c\u7528\u7684\u5bf9\u7167\u7814\u7a76]\u3002Minerva\u513f\u79d1\u533b\u751f\u30021989;41\uff082\uff09\uff1a91\u201395\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2661989\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Minerva%20Pediatr&amp;author=G%20Baldini&amp;author=M%20Gucci&amp;author=D%20Tar%C3%B2&amp;volume=41&amp;issue=2&amp;publication_year=1989&amp;pages=91-95&amp;pmid=2661989&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>81.&nbsp;Dietzsch HJ\uff0c Gottschalk B\uff0c Heyne K \u7b49\u3002\u56ca\u6027\u7ea4\u7ef4\u5316\uff1a\u4e24\u79cd\u7528\u4e8e\u5438\u5165\u6cbb\u7597\u7684\u9ecf\u6db2\u6eb6\u89e3\u836f\u7269\uff08\u4e59\u9170\u534a\u6c28\u9178\u548c\u7cbe\u6c28\u9178\u76d0\u9178\u76d0\uff09\u7684\u6bd4\u8f83\uff0c\u513f\u79d1\u5b66\u30021975\u5e74;55\uff081\uff09\uff1a96\u2013100\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1110869\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Pediatrics&amp;title=Cystic%20fibrosis:%20comparison%20of%20two%20mucolytic%20drugs%20for%20inhalation%20treatment%20(acetylcysteine%20and%20arginine%20hydrochloride)&amp;author=HJ%20Dietzsch&amp;author=B%20Gottschalk&amp;author=K%20Heyne&amp;volume=55&amp;issue=1&amp;publication_year=1975&amp;pages=96-100&amp;pmid=1110869&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>82.&nbsp;Ribeiro TM\u3001Cunha LG\u3001Santos M \u7b49\u3002\u513f\u79d1\u652f\u6c14\u7ba1\u75be\u75c5\u7684\u6cbb\u7597\u3002\u53e3\u670d\u4e59\u9170\u534a\u80f1\u6c28\u9178\u572880\u4f8b\u6848\u4f8b\u4e2d\u4f7f\u7528\u7684\u7ed3\u679c\u3002\u300a\u6b27\u6d32\u8bc4\u8bba\u6742\u5fd7\u300b\u7eed\u7f16\uff0c1980\u5e74;111\uff1a136\u2013138\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6938399\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20J%20Respir%20Dis%20Suppl&amp;title=Treatment%20of%20bronchial%20diseases%20in%20pediatrics.%20results%20of%20the%20use%20of%20oral%20acetylcysteine%20in%2080%20cases&amp;author=TM%20Ribeiro&amp;author=LG%20Cunha&amp;author=M%20Santos&amp;volume=111&amp;publication_year=1980&amp;pages=136-138&amp;pmid=6938399&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>83.&nbsp;Szekely E\uff0c Farkas E. \u513f\u7ae5\u53e3\u670d\u4e59\u9170\u534a\u80f1\u6c28\u9178\u6cbb\u7597\u6162\u6027\u652f\u6c14\u7ba1\u708e\u3002\u300a\u6b27\u6d32\u8bc4\u8bba\u6742\u5fd7\u300b\u7eed\u7f16\uff0c1980\u5e74;61\uff08111\uff09\uff1a142\u3002[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20J%20Respir%20Dis%20Suppl&amp;title=Treatment%20of%20chronic%20bronchitis%20with%20oral%20acetylcysteine%20in%20children&amp;author=E%20Szekely&amp;author=E%20Farkas&amp;volume=61&amp;issue=111&amp;publication_year=1980&amp;pages=142&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>84.&nbsp;\u5c3c\u79d1\u5229\u5947\u00b7P\uff0c\u79d1\u62c9\u8328\u00b7D.\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9\u590d\u53d1\u6027\u652f\u6c14\u7ba1\u708e\u513f\u7ae5\u547c\u5438\u529f\u80fd\u7684\u5f71\u54cd\u3002\u300a\u6b27\u6d32\u8bc4\u8bba\u6742\u5fd7\u300b\u7eed\u7f16\uff0c1980\u5e74;111\uff0861\uff09\uff1a141\u3002[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20J%20Respir%20Dis%20Suppl&amp;title=The%20influence%20of%20acetylcysteine%20on%20respiratory%20functions%20in%20children%20with%20recurrent%20bronchitis&amp;author=P%20Nikolic&amp;author=D%20Korac&amp;volume=111&amp;issue=61&amp;publication_year=1980&amp;pages=141&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>85.&nbsp;Dietzsch HJ\u3001Berger G\u3001Gottschalk B \u7b49\u4eba [\u56ca\u6027\u7ea4\u7ef4\u5316\u513f\u7ae5\u53e3\u670dN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u6cbb\u7597\u7684\u7ecf\u9a8c\uff08\u4f5c\u8005\u8bd1\u6587\uff09]\u3002Z Erkr Atmungsorgane.1980;155\uff081\uff09\uff1a109\u2013113\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7210734\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Z%20Erkr%20Atmungsorgane&amp;author=HJ%20Dietzsch&amp;author=G%20Berger&amp;author=B%20Gottschalk&amp;volume=155&amp;issue=1&amp;publication_year=1980&amp;pages=109-113&amp;pmid=7210734&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>86.&nbsp;Stephan U\uff0c B\u00f6wing B\uff0c Goering U \u7b49\u3002\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u56ca\u6027\u7ea4\u7ef4\u5316\u53e3\u8154\u9ecf\u6db2\u6eb6\u89e3\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002\u300a\u6b27\u6d32\u8bc4\u8bba\u6742\u5fd7\u300b\u7eed\u7f16\uff0c1980\u5e74;111\uff1a127\u2013131\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6938396\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur%20J%20Respir%20Dis%20Suppl&amp;title=Acetylcysteine%20in%20the%20oral%20mucolytic%20treatment%20of%20cystic%20fibrosis&amp;author=U%20Stephan&amp;author=B%20B%C3%B6wing&amp;author=U%20Goering&amp;volume=111&amp;publication_year=1980&amp;pages=127-131&amp;pmid=6938396&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>87.&nbsp;\u91cc\u65af\u00b7HW\u3002N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u6cbb\u7597\u56ca\u6027\u7ea4\u7ef4\u5316\u4e2d\u7684\u5e94\u7528\u3002\u300a\u513f\u79d1\u5b66\u6742\u5fd7\u300b\u30021964;65:542\u2013557.DOI\uff1a10.1016\/S0022-3476\uff0864\uff0980289-4\u3002[<a href=\"https:\/\/doi.org\/10.1016\/s0022-3476(64)80289-4\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14216643\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Pediatr&amp;title=The%20use%20of%20N-acetylcysteine%20in%20the%20treatment%20of%20cystic%20fibrosis&amp;author=HW%20Reas&amp;volume=65&amp;publication_year=1964&amp;pages=542-557&amp;pmid=14216643&amp;doi=10.1016\/s0022-3476(64)80289-4&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>88.&nbsp;Kumar A\uff0c Jat KR\uff0c Srinivas M\uff0c Lodha R. \u96fe\u5316N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7528\u4e8e\u5851\u6599\u652f\u6c14\u7ba1\u708e\u7ba1\u7406\u3002\u5370\u5ea6\u513f\u79d1\u533b\u5b66\u9662\u30022018;55\uff088\uff09\uff1a701\u2013703\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30218522\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Indian%20Pediatr&amp;title=Nebulized%20N-acetylcysteine%20for%20management%20of%20plastic%20bronchitis&amp;author=A%20Kumar&amp;author=KR%20Jat&amp;author=M%20Srinivas&amp;author=R%20Lodha&amp;volume=55&amp;issue=8&amp;publication_year=2018&amp;pages=701-703&amp;pmid=30218522&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>89.&nbsp;Wang Y\uff0c Liu K\uff0c Chen C\uff0c Zhang C. \u4e59\u9170\u534a\u80f1\u6c28\u9178\u548c\u5e03\u5730\u5948\u5fb7\u7528\u4e8e\u6cbb\u7597\u513f\u7ae5\u96be\u6cbb\u6027\u80ba\u708e\u652f\u539f\u4f53\u80ba\u708e\uff1a\u4e34\u5e8a\u89c2\u5bdf\u3002\u300a\u610f\u5927\u5229\u513f\u5b66\u6742\u5fd7\u300b\u30022023;49(1):80.DOI\uff1a10.1186\/S13052-023-01491-Y\u3002[<a href=\"https:\/\/doi.org\/10.1186\/s13052-023-01491-y\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10329323\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37422684\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Ital%20J%20Pediatr&amp;title=Acetylcysteine%20and%20budesonide%20for%20the%20treatment%20of%20refractory%20Mycoplasma%20pneumoniae%20pneumonia%20in%20children:%20a%20clinical%20observation&amp;author=Y%20Wang&amp;author=K%20Liu&amp;author=C%20Chen&amp;author=C%20Zhang&amp;volume=49&amp;issue=1&amp;publication_year=2023&amp;pages=80&amp;pmid=37422684&amp;doi=10.1186\/s13052-023-01491-y&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>90.Macchi&nbsp;A\uff0c Castelnuovo P. \u6162\u6027\u4e0a\u547c\u5438\u9053\u611f\u67d3\u513f\u7ae5\u7684\u6c14\u6eb6\u80f6\u6297\u751f\u7d20\u6cbb\u7597\uff1a\u624b\u672f\u7684\u6f5c\u5728\u66ff\u4ee3\u65b9\u6848\u3002\u56fd\u9645\u514d\u75ab\u75c5\u7406\u836f\u5b66\u6742\u5fd7\u30022009;22(2):303\u2013310.DOI\uff1a10.1177\/039463200902200207\u3002[<a href=\"https:\/\/doi.org\/10.1177\/039463200902200207\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19505384\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int%20J%20Immunopathol%20Pharmacol&amp;title=Aerosol%20antibiotic%20therapy%20in%20children%20with%20chronic%20upper%20airway%20infections:%20a%20potential%20alternative%20to%20surgery&amp;author=A%20Macchi&amp;author=P%20Castelnuovo&amp;volume=22&amp;issue=2&amp;publication_year=2009&amp;pages=303-310&amp;pmid=19505384&amp;doi=10.1177\/039463200902200207&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>91.&nbsp;Dano G. \u54ee\u5598\u513f\u7ae5\u4e2d\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5f15\u8d77\u7684\u652f\u6c14\u7ba1\u75c9\u631b\u3002Acta Allergol\u30021971;26\uff083\uff09\uff1a181\u2013190\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/5109293\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Acta%20Allergol&amp;title=Bronchospasm%20caused%20by%20acetylcysteine%20in%20children%20with%20bronchial%20asthma&amp;author=G%20Dano&amp;volume=26&amp;issue=3&amp;publication_year=1971&amp;pages=181-190&amp;pmid=5109293&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>92.By&nbsp;Leupold W. \u80ba\u5728\u4f7f\u7528Mucosolvin\u6cbb\u7597\u652f\u6c14\u7ba1\u54ee\u5598\u65f6\u7684\u529f\u80fd\u3002[\u63a5\u53d7\u7c98\u6db2\u6eb6\u80f6\u6cbb\u7597\u652f\u6c14\u7ba1\u54ee\u5598\u7684\u80ba\u529f\u80fd]\u3002\u5fb7\u56fd\u7684\u533b\u7597\u4f53\u7cfb\u30021970;25\uff1a1400\u20131402\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/5523854\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Das%20Deutsche%20Gesundheitswesen&amp;title=Lung%20function%20in%20bronchial%20asthma%20during%20treatment%20with%20Mucosolvin&amp;author=W%20Von%20Leupold&amp;volume=25&amp;publication_year=1970&amp;pages=1400-1402&amp;pmid=5523854&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>93. \u6d1b\u65af\u6070\u5c14\u6ce2\u00b7\u62c9\u8499\u591a\u00b7D. \u5173\u4e8e\u4e59\u9170\u534a\u80f1\u6c28\u9178\u548c\u786b\u82ef\u4e8c\u9187\u7518\u6c28\u9178\u76d0\u7ed3\u5408\u5728\u67d0\u4e9b\u513f\u79d1\u80ba\u90e8\u75be\u75c5\u4e2d\u7684\u5e94\u7528\u3002[\u5173\u4e8e\u4e59\u9170\u534a\u80f1\u6c28\u9178\u4e59\u9170\u6c28\u82ef\u4e8c\u915a\u7518\u6c28\u9178\u5728\u67d0\u4e9b\u513f\u79d1\u80ba\u75c5\u4e2d\u7684\u5e94\u7528]\u3002\u4e34\u5e8a\u513f\u79d1\u30021968;50\uff1a43\u201356\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/5737082\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Clinical%20Pediatrics&amp;title=On%20the%20use%20of%20the%20association%20of%20acetylcysteine%20and%20thiamphenicol%20glycinate%20in%20some%20pediatric%20pulmonary%20diseases&amp;author=D%20Loscialpo%20Ramundo&amp;volume=50&amp;publication_year=1968&amp;pages=43-56&amp;pmid=5737082&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>94.&nbsp;V\u00f6lkl KP\uff0c Schneider B. [\u7528N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u6cbb\u7597\u547c\u5438\u9053\u75be\u75c5\u3002\u4e00\u9879\u6db5\u76d62,512\u540d\u60a3\u8005\u7684\u5f00\u653e\u6027\u6cbb\u7597\u89c2\u5bdf\u7814\u7a76]\u3002Fortschr \u533b\u5b66\uff0c1992\u5e74;110\uff0818\uff09\uff1a346\u2013350\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1644396\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Fortschr%20Med&amp;author=KP%20V%C3%B6lkl&amp;author=B%20Schneider&amp;volume=110&amp;issue=18&amp;publication_year=1992&amp;pages=346-350&amp;pmid=1644396&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>95.\u7eb3\u5179\u00b7F\uff0c\u62c9\u624e\u00b7AB\uff0c\u4f0a\u8d3e\u5179\u00b7I\uff0c\u5361\u9f50\u00b7\u8fc8\u3002\u96fe\u5316N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u6eb6\u6db2\u5728\u6025\u6027\u7ec6\u652f\u6c14\u7ba1\u708e\u513f\u7ae5\u4e2d\u7684\u7597\u6548\u3002J Coll\u5916\u79d1\u533b\u5e08\uff0c\u5df4\u57fa\u65af\u5766\uff0c2014\u5e74;24\uff086\uff09\uff1a408\u2013411\u3002[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24953914\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Coll%20Physicians%20Surg%20Pak&amp;title=Effectiveness%20of%20nebulized%20N-acetylcysteine%20solution%20in%20children%20with%20acute%20bronchiolitis&amp;author=F%20Naz&amp;author=AB%20Raza&amp;author=I%20Ijaz&amp;author=MY%20Kazi&amp;volume=24&amp;issue=6&amp;publication_year=2014&amp;pages=408-411&amp;pmid=24953914&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>96.&nbsp;Pandey R\u3001Legard C\u3001Jensen B \u7b49\u4eba 338\uff1a\u96fe\u5316N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7528\u4e8e\u4f4f\u9662\u6025\u6027\u7ec6\u652f\u6c14\u7ba1\u708e\uff1a\u521d\u6b65\u7814\u7a76\u30022024\u5e74\u91cd\u75c7\u76d1\u62a4\u533b\u5b66;52\uff081\uff09\uff1aS144\u3002DOI\uff1a10.1097\/01.ccm.0000999540.42032.42\u3002[<a href=\"https:\/\/doi.org\/10.1097\/01.ccm.0000999540.42032.42\">DOI<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Crit%20Care%20Med&amp;title=338:%20Nebulized%20N-acetylcysteine%20for%20acute%20bronchiolitis%20in%20inpatient%20hospital%20use:%20pilot%20study&amp;author=R%20Pandey&amp;author=C%20Legard&amp;author=B%20Jensen&amp;volume=52&amp;issue=1&amp;publication_year=2024&amp;pages=S144&amp;doi=10.1097\/01.ccm.0000999540.42032.42&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>2024\u5e7497\u6708GINA\u4e3b\u62a5\u544a\u3002\u5168\u7403\u54ee\u5598\u7ba1\u7406\u4e0e\u9884\u9632\u6218\u7565;[\u8bbf\u95ee\u65e5\u671f\uff1a2025\u5e742\u67086\u65e5]\u3002<a href=\"https:\/\/ginasthma.org\/2024-report\/\">https:\/\/ginasthma.org\/2024-report\/<\/a>&nbsp;[<a href=\"https:\/\/scholar.google.com\/scholar_lookup?title=2024%20GINA%20Main%20Report&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>98.&nbsp;\u7f8e\u56fd\u80f8\u79d1\u5b66\u4f1a\u3002\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357\u3001\u9648\u8ff0\u548c\u62a5\u544a\u3002[\u8bbf\u95ee\u65e5\u671f\uff1a2025\u5e742\u67086\u65e5]\u3002<a href=\"https:\/\/site.thoracic.org\/clinicians-researchers\/clinical-practice-guidelines-statements-reports\">https:\/\/site.thoracic.org\/clinicians-researchers\/clinical-practice-guidelines-statements-reports<\/a>\u3002<\/li>\n<li>99.&nbsp;\u660e\u667a\u9009\u62e9\u610f\u5927\u5229\u3002\u907f\u514d\u7ed9\u54ee\u5598\u513f\u7ae5\u5f00\u5177\u6eb6\u9ecf\u5242\u3002[\u8bbf\u95ee\u65e5\u671f\uff1a2025\u5e742\u67086\u65e5]\u3002<a href=\"https:\/\/choosingwiselyitaly.org\/en\/raccomandazione-prof\/avoid-prescribing-mucolytics-in-children-with-bronchial-asthma\/\">https:\/\/choosingwiselyitaly.org\/en\/raccomandazione-prof\/avoid-prescribing-mucolytics-in-children-with-bronchial-asthma\/<\/a><\/li>\n<li>100.&nbsp;\u82f1\u56fd\u80f8\u79d1\u5b66\u4f1a\u3002BTS\/NICE\/SIGN \u54ee\u5598\u5173\u8282\u6307\u5357\uff1a\u8bca\u65ad\u3001\u76d1\u6d4b\u53ca\u6162\u6027\u54ee\u5598\u7ba1\u7406\u3002[\u8bbf\u95ee\u65e5\u671f\uff1a2025\u5e742\u67086\u65e5]\u3002<a href=\"https:\/\/www.brit-thoracic.org.uk\/quality-improvement\/guidelines\/asthma\/\">https:\/\/www.brit-thoracic.org.uk\/quality-improvement\/guidelines\/asthma\/<\/a>&nbsp;[<a href=\"https:\/\/doi.org\/10.1136\/thorax-2024-222910\">DOI<\/a>][<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12322379\/\">PMC\u514d\u8d39\u6587\u7ae0<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40274410\/\">PubMed]<\/a>]<\/li>\n<li>101.&nbsp;Duijvestijn YCM\u3001Mourdi N\u3001Smucny J\u3001Pons G\u3001Chalumeau M. \u4e59\u9170\u534a\u80f1\u6c28\u9178\u548c\u78b3\u534a\u80f1\u6c28\u9178\u7528\u4e8e\u65e0\u6162\u6027\u652f\u6c14\u7ba1-\u80ba\u75be\u75c5\u513f\u7ae5\u7684\u6025\u6027\u4e0a\u547c\u5438\u9053\u548c\u4e0b\u547c\u5438\u9053\u611f\u67d3\u3002Cochrane\u6570\u636e\u5e93\u7cfb\u7edf\u8bc4\u8bba 2009\uff081\uff09\uff1aCD003124\u3002DOI\uff1a10.1002\/14651858.CD003124.pub3\u3002[<a href=\"https:\/\/doi.org\/10.1002\/14651858.CD003124.pub3\">DOI<\/a>][<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19160217\/\">PubMed<\/a>][<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cochrane%20Database%20Syst%20Rev&amp;title=Acetylcysteine%20and%20carbocysteine%20for%20acute%20upper%20and%20lower%20respiratory%20tract%20infections%20in%20paediatric%20patients%20without%20chronic%20broncho-pulmonary%20disease&amp;author=YCM%20Duijvestijn&amp;author=N%20Mourdi&amp;author=J%20Smucny&amp;author=G%20Pons&amp;author=M%20Chalumeau&amp;volume=2009&amp;issue=1&amp;pages=CD003124&amp;pmid=19160217&amp;doi=10.1002\/14651858.CD003124.pub3&amp;\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/li>\n<li>102.CDC\u3002\u751f\u957f\u56fe\u2014\u20142-20\u5c81\u5973\u5b69\u3002[\u8bbf\u95ee\u65e5\u671f\uff1a2024\u5e744\u67087\u65e5]\u3002<a href=\"https:\/\/www.cdc.gov\/growthcharts\/cdc-growth-charts.htm\">https:\/\/www.cdc.gov\/growthcharts\/cdc-growth-charts.htm<\/a>\u3002<\/li>\n<li>103.CDC\u589e\u957f\u56fe\u8868\u2014\u20142-20\u5c81\u7537\u5b69\u3002[\u8bbf\u95ee\u65e5\u671f\uff1a2024\u5e744\u67087\u65e5]\u3002<a href=\"https:\/\/www.cdc.gov\/growthcharts\/cdc-growth-charts.htm\">https:\/\/www.cdc.gov\/growthcharts\/cdc-growth-charts.htm<\/a>\u3002<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\"><a><\/a>\u76f8\u5173\u6570\u636e<\/h2>\n<p class=\"wp-block-paragraph\"><em>\u672c\u8282\u6536\u96c6\u672c\u6587\u4e2d\u5305\u542b\u7684\u4efb\u4f55\u6570\u636e\u5f15\u7528\u3001\u6570\u636e\u53ef\u7528\u6027\u58f0\u660e\u6216\u8865\u5145\u6750\u6599\u3002<\/em><\/p>\n<h3 class=\"wp-block-heading\">\u8865\u5145\u8d44\u6599<\/h3>\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/instance\/12657002\/bin\/dic.2025-7-7-PLS.pdf\">dic.2025-7-7-PLS.pdf<\/a><sup>\uff0861.7KB\uff0cpdf\uff09<\/sup><\/p>\n<h3 class=\"wp-block-heading\">\u6570\u636e\u53ef\u7528\u6027\u58f0\u660e<\/h3>\n<p class=\"wp-block-paragraph\">\u652f\u6301\u672c\u6587\u7ed3\u8bba\u7684\u539f\u59cb\u6570\u636e\u5c06\u7531\u4f5c\u8005\u6839\u636e\u8981\u6c42\u63d0\u4f9b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u539f\u6587\u94fe\u63a5 \u6458\u8981 N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\uff08NAC\uff09\u56e0\u5176\u5728\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u6cbb\u7597\u4e2d\u5177\u6709\u6eb6\u89e3\u9ecf\u6db2\u3001 &hellip; <a href=\"http:\/\/zydq.1006ss.com\/?p=67491\">\u7ee7\u7eed\u9605\u8bfb <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[194],"class_list":["post-67491","post","type-post","status-publish","format-standard","hentry","category-70","tag-194"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/67491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=67491"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/67491\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=67491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=67491"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=67491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}