{"id":67446,"date":"2026-08-20T07:56:32","date_gmt":"2026-08-20T07:56:32","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=67446"},"modified":"2026-08-20T07:56:32","modified_gmt":"2026-08-20T07:56:32","slug":"%e9%9d%92%e8%92%bf%e5%8c%96%e5%85%89%e5%90%88%e5%89%82%e8%81%94%e5%90%88%e6%b9%bf%e6%b6%a6%e7%83%a7%e4%bc%a4%e8%86%8f%e6%b2%bb%e7%96%97%e6%97%a5%e5%85%89%e6%80%a7%e7%9a%ae%e7%82%8e%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=67446","title":{"rendered":"\u9752\u84bf\u5316\u5149\u5408\u5242\u8054\u5408\u6e7f\u6da6\u70e7\u4f24\u818f\u6cbb\u7597\u65e5\u5149\u6027\u76ae\u708e\u4e34\u5e8a\u7814\u7a76"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/www.cjwk.cn\/journal\/guidelinesDetails\/1711646788013760883\">\u539f\u6587\u94fe\u63a5<\/a><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.cjwk.cn\/searchresult\/guidelines?title=%E5%88%98%E7%95%85&amp;selectOption=12\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"\">\u5218\u7545<\/a><a href=\"https:\/\/www.cjwk.cn\/searchresult\/guidelines?title=%E5%BC%A0%E8%8E%B9%E8%8E%B9&amp;selectOption=12\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"\">\u5f20\u83b9\u83b9<\/a><a href=\"https:\/\/www.cjwk.cn\/searchresult\/guidelines?title=%E7%8E%8B%E5%AE%87&amp;selectOption=12\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"\">\u738b\u5b87<\/a><a href=\"https:\/\/www.cjwk.cn\/searchresult\/guidelines?title=%E5%AE%89%E6%9C%88%E9%B9%8F&amp;selectOption=12\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"\">\u5b89\u6708\u9e4f<\/a> <a href=\"https:\/\/www.cjwk.cn\/searchresult\/guidelines?title=%E9%BB%91%E9%BE%99%E6%B1%9F%E4%B8%AD%E5%8C%BB%E8%8D%AF%E5%A4%A7%E5%AD%A6%E9%99%84%E5%B1%9E%E7%AC%AC%E4%B8%80%E5%8C%BB%E9%99%A2&amp;selectOption=13\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ed1\u9f99\u6c5f\u4e2d\u533b\u836f\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662<\/a><\/p>\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\uff1a<\/strong>&nbsp;\u76ee\u7684:\u89c2\u5bdf\u9752\u84bf\u5316\u5149\u5408\u5242\u8054\u5408<mark class=\"has-inline-color 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has-vivid-red-color\">\u7ed3\u8bba:\u9752\u84bf\u5316\u5149\u5408\u5242\u8054\u5408\u6e7f\u6da6\u70e7\u4f24\u818f\u5185\u5916\u540c\u6cbb,\u53ef\u9488\u5bf9\u75be\u75c5\u4e4b\u6e90\u5316\u5149\u8000\u4e4b\u4f24, \u4ee5\u5185\u9664\u70ed\u6bd2\u3001\u6e05\u5316\u6691\u6e7f, \u5916\u795b\u98ce\u75d2.<\/mark><\/strong><\/p>\n<p class=\"wp-block-paragraph\">\n<figure class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" title=\"\u9752\u84bf\u5316\u5149\u5408\u5242\u8054\u5408\u6e7f\u6da6\u70e7\u4f24\u818f\u6cbb\u7597\u65e5\u5149\u6027\u76ae\u708e\u4e34\u5e8a\u7814\u7a76 - \u7b2c1\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u9752\u84bf\u5316\u5149\u5408\u5242\u8054\u5408\u6e7f\u6da6\u70e7\u4f24\u818f\u6cbb\u7597\u65e5\u5149\u6027\u76ae\u708e\u4e34\u5e8a\u7814\u7a76 - \u7b2c1\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" data-perfmatters-preload width=\"510\" height=\"248\" src=\"https:\/\/jiankangpaidu.com\/wp-content\/uploads\/2026\/02\/\u7f8e\u5b9d\u6e7f\u6da6\u70e7\u4f24\u818f-1.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image no-lazy\" alt style=\"object-fit:cover\" \/><\/figure>\n<p class=\"wp-block-paragraph\">\n<h2 class=\"wp-block-heading\">\u300a\u9752\u84bf\u7d20\u53ca\u5176\u884d\u751f\u7269\u5728\u76ae\u80a4\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u7814\u7a76\u53ca\u4e34\u5e8a\u5e94\u7528\u300b<\/h2>\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/www.qk.sjtu.edu.cn\/jdcp\/article\/2019\/1671-2870\/1671-2870-18-2-233.shtml\">\u539f\u6587\u94fe\u63a5&nbsp;<\/a><\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u4f59\u7ea2, \u738b\u4e00\u98de, \u9648\u4f73, \u9648\u6d01, \u674e\u658c.&nbsp;\u9752\u84bf\u7d20\u53ca\u5176\u884d\u751f\u7269\u5728\u76ae\u80a4\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u7814\u7a76\u53ca\u4e34\u5e8a\u5e94\u7528[J]. \u8bca\u65ad\u5b66\u7406\u8bba\u4e0e\u5b9e\u8df5, 2019, 18(2): 233-236 doi:10.16150\/j.1671-2870.2019.02.022<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00005\">\u9752\u84bf\u662f\u4e00\u5473\u5e38\u7528\u4e2d\u836f\uff0c\u800c\u9752\u84bf\u4e2d\u63d0\u53d6\u7684\u9752\u84bf\u7d20\u662f\u6211\u56fd\u7b2c\u4e00\u4e2a\u81ea\u884c\u7814\u5236\u7684\u836f\u7269\uff0c\u4ee5\u6cbb\u7597\u759f\u75be\u800c\u88ab\u4e16\u4eba\u6240\u5e7f\u6cdb\u8ba4\u77e5\u3002\u76ee\u524d, 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href=\";\">1<\/a>]<\/sup>\u53d1\u73b0\uff0c\u84bf\u7532\u919a\u80fd\u663e\u8457\u6291\u5236T\u7ec6\u80de\u6297\u539f\u53d7\u4f53TCR\u8bf1\u5bfc\u7684T\u7ec6\u80de\u589e\u6b96\u4ee5\u53ca\u767d\u7ec6\u80de\u4ecb\u7d20\uff08interlukin, IL\uff09-2\u548c\u5e72\u6270\u7d20\u03b3\uff08interferon \u03b3, IFN-\u03b3\uff09\u7684\u751f\u6210\u3002Liu\u7b49<sup>[<a href=\";\">2<\/a>]<\/sup>\u53d1\u73b0\uff0c\u53cc\u6c22\u9752\u84bf\u7d20\u53ef\u4ee5\u8c03\u8282Th1\/Th2\u5931\u8861\uff0c\u53cc\u6c22\u9752\u84bf\u7d20\u53ef\u4ee5\u964d\u4f4e\u81ea\u8eab\u514d\u75ab\u6027\u7532\u72b6\u817a\u708e\u5c0f\u9f20\u8840\u6e05\u4e2d\u5f02\u5e38\u5347\u9ad8\u7684IFN-\u03b3\u548cIL-2\uff0c\u5347\u9ad8\u5f02\u5e38\u964d\u4f4e\u7684IL-4\u548cIL-6\uff0c\u534f\u8c03\u514d\u75ab\u529f\u80fd\u5931\u8c03\u4e0eTh1\/Th2\u7ec6\u80de\u56e0\u5b50\u7684\u53d8\u5316\u3002\u76ae\u80a4\u75c5\u4e2d\u94f6\u5c51\u75c5\u7684\u53d1\u75c5\u673a\u5236\u4e0eT\u7ec6\u80de\u514d\u75ab\u53ca\u7ec6\u80de\u56e0\u5b50\u76f8\u5173\uff0c\u76ee\u524d\u8ba4\u4e3a\u5176\u662fTh1\u7ec6\u80de\u7684\u75be\u75c5\uff0c\u60a3\u8005\u76ae\u635f\u4e2dTh1\u7ec6\u80de\u56e0\u5b50IFN-\u03b3\u548cIL-2\u589e\u52a0\uff0c\u6297\u708e\u56e0\u5b50IL-10\u51cf\u5c11\uff0c\u7531\u6b64\u53ef\u4ee5\u63a8\u6d4b\uff0c\u9752\u84bf\u7d20\u53ca\u5176\u884d\u751f\u7269\u5bf9\u8be5\u75c5\u5177\u6709\u6291\u5236\u4f5c\u7528\u3002\u53e6\u5916\uff0cTh17\u6d3b\u5316\u4ea7\u751fIL-17\u53caIL-22\u7b49\u5bfc\u81f4\u7684\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u589e\u6b96\uff0c\u4e5f\u53ef\u8bf1\u53d1\u94f6\u5c51\u75c5\u3002\u91d1\u6167\u73b2\u7b49<sup>[<a href=\";\">3<\/a>]<\/sup>\u53d1\u73b0\uff0c\u5916\u75281.5%\u7684\u9752\u84bf\u7425\u916f\u6eb6\u6db2\uff0c\u80fd\u591f\u663e\u8457\u6291\u5236\u94f6\u5c51\u75c5\u5c0f\u9f20\u4e0a\u76ae\u7ec6\u80de\u7684\u6709\u4e1d\u5206\u88c2\uff0c\u4fc3\u8fdb\u8868\u76ae\u9897\u7c92\u5c42\u751f\u6210\uff0c\u4ece\u800c\u6291\u5236\u8868\u76ae\u589e\u6b96\u548c\u89d2\u5316\uff0c\u5176\u4f5c\u7528\u4e0e\u54c8\u897f\u5948\u5fb7\u6eb6\u6db2\u76f8\u4f3c\uff0c\u5374\u4e0d\u4ea7\u751f\u76ae\u80a4\u840e\u7f29\uff0c\u56e0\u6b64\u63d0\u51fa\u9752\u84bf\u7d20\u7c7b\u836f\u7269\u5916\u7528\u6cbb\u7597\u94f6\u5c51\u75c5\u53ef\u80fd\u5177\u6709\u826f\u597d\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00035\">\uff082\uff09\u6291\u5236T\u7ec6\u80de\u6d3b\u5316\u53ca\u4fc3\u8fdbT\u7ec6\u80de\u51cb\u4ea1\uff1a\u65b0\u578b\u9752\u84bf\u7d20\u884d\u751f\u7269SM\u7cfb\u5217\u6c34\u6eb6\u6027\u9ad8\uff0c\u5176\u4f53\u5916\u514d\u75ab\u6291\u5236\u6d3b\u6027\u4e3b\u8981\u96c6\u4e2d\u5728\u6291\u5236T\u7ec6\u80de\u6d3b\u5316\uff0c\u800cT\u7ec6\u80de\u6d3b\u5316\u53ef\u4ee5\u4ea7\u751fIFN-\u03b3\u3001IL-2\u7b49\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u3002\u7814\u7a76\u63d0\u793a,SM735\u5bf9\u6709\u4e1d\u5206\u88c2\u539f\u5200\u8c46\u86cb\u767dCon A\u523a\u6fc0\u7684\u813e\u7ec6\u80de\u589e\u6b96\u548cIFN-\u03b3\u7684\u751f\u6210\u6709\u663e\u8457\u6291\u5236\u4f5c\u7528<sup>[<a href=\";\">4<\/a>]<\/sup>\uff0c\u5176\u8fd8\u80fd\u663e\u8457\u6291\u5236\u8102\u591a\u7cd6\u523a\u6fc0\u813e\u7ec6\u80de\u4ea7\u751fIL-12\u3001IFN-\u03b3\u548cIL-6\u3002SM905\u7684\u514d\u75ab\u8c03\u8282\u7279\u6027\u4e0eSM735\u76f8\u4f3c\u3002\u540c\u6837\uff0c\u4e0eSM905\u53ca\u84bf\u7532\u919a\u76f8\u4f3c\uff0cSM934\u5728\u4f53\u5916\u5bf9\u6df7\u5408\u6dcb\u5df4\u7ec6\u80de\u53cd\u5e94\uff08mixed lymphocyte reaction, MLR\uff09\u6216\u7ecfT\u7ec6\u80de\u6297\u539f\u53d7\u4f53\uff08T cell receptor, TCR\uff09\u4ea4\u8054\u8bf1\u5bfc\u7684\u813e\u7ec6\u80de\u6216\u7eaf\u5316\u7684CD4<sup>+<\/sup>T\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u4ee5\u53caIFN-\u03b3\u751f\u6210\u6709\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u901a\u8fc7CD69\u4e0e\u819c\u8054\u86cb\u767d\u2164\u7684\u8054\u5408\u67d3\u8272\uff0c\u53d1\u73b0SM934\u4f18\u5148\u4fc3\u8fdb\u6d3b\u5316\u7684T\u7ec6\u80de\u65e9\u671f\u51cb\u4ea1\uff0c\u4ece\u800c\u4f7f\u9759\u6b62\u7684T\u7ec6\u80de\u4e0d\u53d7\u5f71\u54cd<sup>[<a href=\";\">5<\/a>]<\/sup>\u3002\u4f46\u4e0eSM905\u3001SM735\u53ca\u84bf\u7532\u919a\u4e0d\u540c\uff0cSM934\u5bf9T\u7ec6\u80de\u7684IL-2\u751f\u6210\u548cCD25\u4e0a\u8c03\u6ca1\u6709\u5f71\u54cd\uff0c\u5176\u6291\u5236IL-2\u4ecb\u5bfc\u7684T\u7ec6\u80de\u589e\u6b96\u548c\u5b58\u6d3b\u7684\u4f5c\u7528\u53ef\u80fd\u662f\u5176\u963b\u65ad\u4e86IL-2\u8bf1\u5bfc\u7684Akt\u78f7\u9178\u5316\u7684\u7ed3\u679c\u3002\u6700\u8fd1\uff0cSM934\u5df2\u88ab\u4e2d\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u4f5c\u4e3a\u6cbb\u7597\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u7684\u65b0\u578b\u836f\u7269\u800c\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00040\">\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u5c5e\u4e8e\u591a\u7cfb\u7edf\u53d7\u7d2f\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5176\u53d1\u75c5\u673a\u5236\u4e3b\u8981\u8868\u73b0\u5728T\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\uff0c\u6291\u5236\u6027T\u7ec6\u80de\u529f\u80fd\u5f02\u5e38\uff0cIL-2\u4ea7\u751f\u589e\u52a0\uff0c\u4f7fB\u7ec6\u80de\u591a\u514b\u9686\u6fc0\u6d3b\u4ea7\u751f\u5927\u91cf\u81ea\u8eab\u6297\u4f53\u800c\u81f4\u75c5\u3002\u7531\u6b64\u53ef\u89c1\uff0c\u9752\u84bf\u7d20\u53ca\u5176\u884d\u751f\u7269\u5177\u6709\u5bf9\u5176\u6cbb\u7597\u7684\u4f5c\u7528\u57fa\u7840\u3002\u6731\u536b\u661f\u7b49<sup>[<a href=\";\">6<\/a>]<\/sup>\u5236\u4f5c\u4e86\u72fc\u75ae\u5c0f\u9f20\u7684\u6a21\u578b\u8fdb\u884c\u7814\u7a76\uff0c\u91c7\u7528\u9176\u8054\u514d\u75ab\u5438\u9644\u6d4b\u5b9a\u53d1\u73b0\u72fc\u75ae\u5c0f\u9f20\u8840\u6e05\u4e2d\u7684IL-6\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff0c\u8fbe\uff0866.2\u00b155.5\uff09 pq\/mL[\u6b63\u5e38\u5bf9\u7167\u4e3a\uff0818.8\u00b115.4\uff09 pq\/mL]\uff0c\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2\uff08transforming growth factor-\u03b2, TGF-\u03b2\uff09\u6c34\u5e73\u663e\u8457\u4e0b\u964d\u81f3\uff0878.2\u00b142.3\uff09 pq\/mL[\u6b63\u5e38\u5bf9\u7167\u4e3a\uff08152.6\u00b156.9\uff09 pq\/mL]\uff0c\u800c\u7ecf\u9752\u84bf\u7425\u916f\u6cbb\u7597\u540e\u7684\u72fc\u75ae\u5c0f\u9f20\u8840\u6e05IL-6\u6c34\u5e73\u5927\u5e45\u5ea6\u4e0b\u964d\u81f3\uff0839.2\u00b120.2\uff09 pq\/mL\uff0cTGF-\u03b2\u6c34\u5e73\u57fa\u672c\u6062\u590d\u6b63\u5e38\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00045\">2. \u4e34\u5e8a\u5e94\u7528\uff1a\u76ee\u524d\u4e34\u5e8a\u4e0a\u5c1a\u4ec5\u6709\u5c06\u7eaf\u4e2d\u836f\u9752\u84bf\u4f5c\u4e3a\u65b9\u5242\u4e4b\u4e00\uff0c\u5e94\u7528\u4e8e\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u94f6\u5c51\u75c5\u7b49\u514d\u75ab\u6027\u76ae\u80a4\u75c5\u7684\u6cbb\u7597\u4e2d\uff0c\u800c\u5173\u4e8e\u9752\u84bf\u7c7b\u884d\u751f\u7269\u5728\u514d\u75ab\u6027\u76ae\u80a4\u75c5\u4e2d\u7684\u4e34\u5e8a\u5e94\u7528\u76ee\u524d\u5c1a\u672a\u89c1\u62a5\u9053\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00050\">\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u60a3\u8005\u5e38\u4f34\u6709\u76ae\u80a4\u53d7\u635f\uff0c\u6216\u4ec5\u6709\u76ae\u80a4\u53d7\u635f\u3002\u4e2d\u533b\u4e34\u8bca\u4e2d\uff0c\u65b9\u5242\u9752\u84bf\u9cd6\u7532\u6c64\u51fa\u81ea\u6e05\u4ee3\u5434\u97a0\u901a\u6240\u8457\u7684\u300a\u6e29\u75c5\u6761\u8fa8\u300b\u5377\u4e09\uff0c\u662f\u6e05\u865a\u70ed\u7684\u4ee3\u8868\u65b9\u3002\u9ad8\u5f3c\u864e\u7b49<sup>[<a href=\";\">7<\/a>]<\/sup>\u5c0660\u4f8b\u9634\u865a\u5185\u70ed\u578b\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u60a3\u8005\u968f\u673a\u5206\u6210\u897f\u533b\u5bf9\u7167\u7ec4\u548c\u9752\u84bf\u9cd6\u7532\u6c64\u8054\u5408\u897f\u533b\u6cbb\u7597\u7ec4\uff0c\u6bd4\u8f832\u7ec4\u7684\u4e34\u5e8a\u7597\u6548\u3001\u6cbb\u7597\u524d\u540e\u4e2d\u533b\u8bc1\u5019\u8bc4\u5206,\u5e76\u68c0\u6d4b\u6cbb\u7597\u524d\u540e\u5916\u5468\u8840\u6dcb\u5df4\u7ec6\u80de\u4e9a\u7fa4\u7684\u53d8\u5316\u3002\u7ed3\u679c\u663e\u793a\uff0c\u897f\u836f\u8054\u5408\u9752\u84bf\u9cd6\u7532\u6c64\u6cbb\u7597\u80fd\u591f\u6709\u6548\u964d\u4f4e\u60a3\u8005\u7684\u4e2d\u533b\u4e34\u5e8a\u8bc1\u5019\u79ef\u5206\uff0c\u83b7\u663e\u8457\u7597\u6548\uff0c\u5e76\u80fd\u6539\u5584 Th\/Ts\u5931\u8861\u72b6\u6001\uff08\u5b9e\u9a8c\u7ec4Th\/Ts\u6cbb\u7597\u524d\u7ea6\u4e3a0.67\uff0c\u6cbb\u7597\u540e\u7ea6\u4e3a0.89\uff09\u3002\u4e4b\u540e\uff0c\u66f9\u5411\u4e1c\u7b49<sup>[<a href=\";\">8<\/a>]<\/sup>\u7528\u7c7b\u4f3c\u7684\u65b9\u6cd5\uff0c\u4ee5\u5355\u72ec\u897f\u533b\u6cbb\u7597\u4e3a\u5bf9\u7167\uff0c\u7814\u7a76\u9752\u84bf\u9cd6\u7532\u6c64\u8054\u5408\u897f\u533b\u6cbb\u7597\u9634\u865a\u5185\u70ed\u578b\u7684\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3002\u7ed3\u679c\u540c\u6837\u8bc1\u5b9e\uff0c\u8054\u5408\u7528\u836f\u7597\u6548\u4f18\u4e8e\u5355\u72ec\u897f\u533b\u6cbb\u7597\uff0c\u524d\u8005\u6cbb\u7597\u6709\u6548\u7387\u8fbe96.67%\uff0c\u800c\u540e\u8005\u4e3a66.67%\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00055\">\u5bf9\u4e8e\u4ee5Th1\/Th2\u5931\u8861\u4e3a\u4e3b\u8981\u53d1\u75c5\u673a\u5236\u7684\u94f6\u5c51\u75c5,\u56db\u5ddd\u9ec4\u83ba\u6559\u6388\u7b49<sup>[<a href=\";\">9<\/a>]<\/sup>\u7528\u9752\u84bf\u914d\u4f0d\u571f\u832f\u82d3\u7b49\u7ec4\u6210\u4e2d\u836f\u5408\u5242\u6cbb\u7597\u706b\u70ed\u70bd\u76db\u578b\u94f6\u5c51\u75c5\uff0c1\u5468\u540e\u60a3\u8005\u6f6e\u7ea2\u76ae\u635f\u660e\u663e\u51cf\u5c11\uff0c\u76ae\u6e29\u964d\u4f4e\uff0c\u8131\u5c51\u51cf\u5c11\uff0c\u83b7\u5f97\u4e86\u826f\u597d\u7684\u7597\u6548\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00060\">\u4e8c\u3001\u6297\u708e\u3001\u6297\u8fc7\u654f\u4f5c\u7528<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00065\">1. \u76f8\u5173\u673a\u5236\uff1a\u9664\u4e86\u514d\u75ab\u8c03\u8282\u5916\uff0c\u9752\u84bf\u7d20\u53ca\u5176\u884d\u751f\u7269\u5bf9\u708e\u75c7\u4ecb\u8d28\u4e5f\u6709\u4f5c\u7528\u3002\u83ab\u6b63\u9b41\u7b49<sup>[<a href=\";\">10<\/a>]<\/sup>&nbsp;\u7684\u5b9e\u9a8c\u53d1\u73b0,\u9752\u84bf\u7d20\u53ef\u964d\u4f4e\u5c0f\u9f20\u8840\u6e05\u4e2dIFN-\u03b3\u7684\u6c34\u5e73\uff0c\u7ec6\u80de\u95f4\u9ecf\u9644\u5206\u5b501\u8868\u8fbe\u4e0b\u964d\uff0c\u5355\u6838\u7ec6\u80de\u6297\u539f\u9012\u5448\u529f\u80fd\u51cf\u5f31\uff0c\u51cf\u5c11\u4e86\u5355\u6838\u7ec6\u80de\u548c\u6dcb\u5df4\u7ec6\u80de\u5c40\u90e8\u6d78\u6da6\uff0c\u4ece\u800c\u6291\u5236\u4e86\u514d\u75ab\u53cd\u5e94\uff0c\u51cf\u8f7b\u708e\u75c7\u635f\u4f24\u3002\u60e0\u6d77\u82f1\u7b49<sup>[<a href=\";\">11<\/a>&#8211;<a href=\";\">12<\/a>]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0c\u53cc\u6c22\u9752\u84bf\u7d20\u5bf9\u7d2b\u5916\u7ebf\u6240\u81f4\u7684\u5c0f\u9f20\u5149\u635f\u4f24\u4e2d\u708e\u75c7\u56e0\u5b50IL-1\u3001IL-6\u53ca\u51cb\u4ea1\u86cb\u767d Caspase-3\u3001Caspase-8\u7684\u4ea7\u751f\u5177\u6709\u4e00\u5b9a\u6291\u5236\u4f5c\u7528\uff0c\u5e76\u53ef\u6291\u5236\u7d2b\u5916\u7ebf\u6240\u81f4\u4eba\u6c38\u751f\u5316\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\uff08HaCaT\u7ec6\u80de\uff09\u7684\u51cb\u4ea1\uff0c\u63a8\u6d4b\u5176\u673a\u5236\u53ef\u80fd\u4e0ecaspase-3\u53ca\u51cb\u4ea1\u6291\u5236\u57fa\u56e0survivin\u6709\u5173\u3002\u6709\u5b66\u8005\u7814\u7a76\u53d1\u73b0,\u9752\u84bf\u7425\u916f\u53ef\u80fd\u901a\u8fc7PI3K\/Akt\u901a\u8def\u7684\u8d1f\u8c03\u8282\u548c\u963b\u65adIgE\u8bf1\u5bfc\u7684\u80a5\u5927\u7ec6\u80de\u8131\u9897\u7c92<sup>[<a href=\";\">13<\/a>]<\/sup>\u3002\u4e0a\u8ff0\u7814\u7a76\u63d0\u793a,\u9752\u84bf\u7c7b\u884d\u751f\u7269\u5bf9\u5149\u6bd2\u6027\u3001\u8fc7\u654f\u6027\u75be\u75c5\u6709\u6f5c\u5728\u4f5c\u7528\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00070\">2. \u4e34\u5e8a\u5e94\u7528\uff1a\u540c\u6837\uff0c\u76ee\u524d\u9752\u84bf\u7c7b\u836f\u5728\u4e34\u5e8a\u6297\u708e\u3001\u6297\u8fc7\u654f\u6027\u76ae\u80a4\u75c5\u4e2d\u7684\u5e94\u7528\u4e5f\u4ec5\u5c40\u9650\u4e8e\u9752\u84bf\u3002\u708e\u6027\u76ae\u80a4\u75c5\u4e2d\u65e5\u5149\u6027\u76ae\u708e\u4e0d\u4ec5\u662f\u5149\u6bd2\u6027\u53cd\u5e94\uff0c\u4e5f\u662f\u4e00\u79cd\u53d8\u6001\u53cd\u5e94\u3002\u5218\u7545\u7b49<sup>[<a href=\";\">14<\/a>]<\/sup>\u91c7\u7528\u9752\u84bf\u5316\u5149\u5408\u5242\uff08\u9752\u84bf15 g\uff0c\u5730\u698615 g\uff0c\u8d64\u828d15 g\uff0c\u9ec4\u82a915 g\uff0c\u82e6\u53c215 g\uff0c\u5730\u9aa8\u76ae20 g\uff0c\u8335\u964815 g\uff09\u8054\u5408\u6e7f\u6da6\u70e7\u4f24\u818f\u6cbb\u7597\u65e5\u5149\u6027\u76ae\u708e\uff0c\u5176\u5c06\u60a3\u8005\u5206\u4e3a2\u7ec4\uff0c\u6cbb\u7597\u7ec4\u60a3\u8005\u53e3\u670d\u9752\u84bf\u5316\u5149\u5408\u5242\u8054\u5408\u5916\u7528\u6e7f\u6da6\u70e7\u4f24\u818f\uff0c\u5bf9\u7167\u7ec4\u60a3\u8005\u53e3\u670d\u6c2f\u96f7\u4ed6\u5b9a\u7247\uff0c\u91c7\u7528\u5ba2\u89c2\u76ae\u635f\u8bc4\u5206\u548c\u7619\u75d2\u89c6\u89c9\u6a21\u62df\u8bc4\u5206\u8bc4\u4ef7\u7597\u6548\u3002\u7ed3\u679c\u663e\u793a\uff0c\u6cbb\u7597\u7ec4\u76ae\u635f\u6cbb\u7597\u7684\u603b\u6709\u6548\u7387\u4e3a75.0%\uff0c\u800c\u5bf9\u7167\u7ec4\u5219\u4e3a35.7%\uff0c\u6cbb\u7597\u7ec4\u6240\u83b7\u5f97\u7597\u6548\u660e\u663e\u4f18\u4e8e\u5bf9\u7167\u7ec4\uff08<em>P<\/em>&lt;0.05\uff09\u3002\u540c\u65f6\uff0c\u6cbb\u7597\u7ec4\u7684\u6cbb\u7597\u540e\u7619\u75d2\u8bc4\u5206\u4e5f\u660e\u663e\u4f18\u4e8e\u5bf9\u7167\u7ec4\uff08<em>P<\/em>&lt;0.05\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c\u9752\u84bf\u5316\u5149\u5408\u5242\u8054\u5408\u6e7f\u6da6\u70e7\u4f24\u818f\u5185\u5916\u540c\u6cbb\u5bf9\u4e8e\u65e5\u5149\u6027\u76ae\u708e\u6709\u8f83\u597d\u7597\u6548\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00075\">\u8368\u9ebb\u75b9\u4f5c\u4e3a\u5e38\u89c1\u7684\u76ae\u80a4\u75c5\u4e4b\u4e00\uff0c\u53ef\u7531\u6297\u539f\u6297\u4f53\u6216\uff08\u548c\uff09\u8865\u4f53\u53cd\u5e94\u6216T\u7ec6\u80de\u4ecb\u5bfc\u6240\u81f4;\u4e5f\u53ef\u4ee5\u7531\u7ec6\u80de\u56e0\u5b50\u7b49\u5f15\u8d77\u80a5\u5927\u7ec6\u80de\u76f4\u63a5\u8131\u9897\u7c92\u81f4\u75c5\u3002\u660e\u738b\u80af\u5802\u300a\u8bc1\u6cbb\u51c6\u7ef3\u300b\u7684\u6e05\u9aa8\u6563\u4e0e\u9752\u84bf\u9cd6\u7532\u6c64\u4e00\u6837\u662f\u6e05\u865a\u70ed\u7684\u4ee3\u8868\u65b9\u5242\uff0c\u7531\u9752\u84bf\u3001\u79e6\u827d\u3001\u918b\u7099\u9cd6\u7532\u7b49\u516b\u5473\u4e2d\u836f\u914d\u4f0d\u800c\u6210\u3002\u9a6c\u5efa\u56fd\u7b49<sup>[<a href=\";\">15<\/a>]<\/sup>\u7528\u6e05\u9aa8\u6563\u52a0\u51cf\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u8368\u9ebb\u75b9\u548c\u76ae\u80a4\u7619\u75d2\u75c7\uff0c\u80fd\u660e\u663e\u51cf\u8f7b\u7619\u75d2\u53ca\u76ae\u80a4\u707c\u70ed\u611f\uff0c\u5e76\u80fd\u51cf\u5c11\u8368\u9ebb\u75b9\u76ae\u75b9\u7684\u53d1\u4f5c\u9891\u7387\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00080\">\u4ee5\u4e0a\u79cd\u79cd\u8868\u660e\uff0c\u9752\u84bf\u53ca\u5176\u884d\u751f\u7269\u5177\u6709\u8c03\u8282\u514d\u75ab\u3001\u6297\u708e\u3001\u6297\u8fc7\u654f\u7b49\u4f5c\u7528\uff0c\u9752\u84bf\u5728\u7ea2\u6591\u72fc\u75ae\u3001\u94f6\u5c51\u75c5\u3001\u65e5\u5149\u6027\u76ae\u708e\u53ca\u8368\u9ebb\u75b9\u7b49\u75be\u75c5\u7684\u6cbb\u7597\u4e2d\u5747\u8d77\u5230\u4e00\u5b9a\u7684\u4f5c\u7528\uff0c\u5176\u884d\u751f\u7269\u5728\u514d\u75ab\u6027\u53ca\u53d8\u6001\u53cd\u5e94\u6027\u7b49\u76ae\u80a4\u75be\u75c5\u4e2d\u7684\u5e94\u7528\u5c06\u5177\u6709\u5e7f\u9614\u524d\u666f\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<h2 class=\"wp-block-heading\" id=\"outline_anchor_2\">\u9752\u84bf\u7d20\u53ca\u5176\u884d\u751f\u7269\u4e0e\u611f\u67d3\u6027\u76ae\u80a4\u75c5<\/h2>\n<p class=\"wp-block-paragraph\" id=\"p00090\">\u9752\u84bf\u7d20\u53ca\u5176\u884d\u751f\u7269\u6297\u611f\u67d3\u65b9\u9762\u4e3b\u8981\u4f53\u73b0\u5728\u6297\u771f\u83cc\u7684\u4f5c\u7528\uff0c\u5176\u6b21\u662f\u6297\u7ec6\u83cc\u4f5c\u7528\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00095\">\u4e00\u3001\u6297\u771f\u83cc\u4f5c\u7528<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00100\">1. \u76f8\u5173\u673a\u5236\uff1a\u718a\u8fd0\u6d77\u3001\u5f20\u4e3d\u52c7\u7b49<sup>[<a href=\";\">16<\/a>&#8211;<a href=\";\">17<\/a>]<\/sup>\u5148\u540e\u901a\u8fc7\u4f53\u5916\u5b9e\u9a8c\u8bc1\u5b9e\uff0c\u9752\u84bf\u63d0\u53d6\u7269\u5177\u6709\u6297\u771f\u83cc\u4f5c\u7528\uff0c\u5176\u4e2d\u53d1\u73b0\u9752\u84bf\u63d0\u53d6\u7269\u5bf9\u9ed1\u66f2\u9709\u548c\u9a6c\u9752\u9709\u7684\u6700\u4f4e\u6291\u83cc\u6d53\u5ea6\u4e3a1.25%\uff0c\u5bf9\u9752\u9709\u7684\u6700\u4f4e\u6291\u83cc\u6d53\u5ea6\u4e3a5%\u3002\u9752\u84bf\u7d20\u7c7b\u836f\u7269\u5728\u4f53\u5916\u6709\u6297\u5361\u6c0f\u80ba\u5b62\u5b50\u866b\u3001\u65b0\u751f\u9690\u7403\u83cc\u3001\u70df\u66f2\u9709\u83cc\u7684\u4f5c\u7528\u3002\u9752\u84bf\u7d20\u7c7b\u836f\u7269\u7684\u6297\u771f\u83cc\u6d3b\u6027\u53ef\u80fd\u4e0e\u5176\u5185\u8fc7\u6c27\u5316\u7ed3\u6784\u53ca1, 2, 4-\u4e09\u6c27\u6742\u73af\u5df1\u70f7\u76845-\u4f4d\u6c27\u539f\u5b50\u9ad8\u5ea6\u76f8\u5173\uff0c\u800c\u8fd9\u4e5f\u662f\u5176\u6297\u759f\u6d3b\u6027\u7684\u91cd\u8981\u7ed3\u6784\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00105\">2. \u4e34\u5e8a\u5e94\u7528\uff1a\u9648\u5fb7\u5b87\u7b49<sup>[<a href=\";\">18<\/a>]<\/sup>\u5c06\u65b0\u9c9c\u9752\u84bf\u52a0\u84b8\u998f\u6c34\u7b49\u5236\u62105%\u7684\u9752\u84bf\u6cb9\u643d\u5242\uff0c\u5355\u72ec\u5916\u7528\u5176\u4ee5\u6cbb\u7597\u6d45\u90e8\u771f\u83cc\u75c5\u60a3\u8005\uff0c\u53d1\u73b0\u6cbb\u6108\u7387\u8fbe77.0%\uff0c\u7597\u6548\u53ef\u4e0e2%\u54aa\u5eb7\u5511\u971c\uff0867.7%\uff09\u5ab2\u7f8e\u3002\u5f20\u96c4\u8f89\u7b49<sup>[<a href=\";\">19<\/a>]<\/sup>\u7814\u7a76\u8ba4\u4e3a\uff0c\u9752\u84bf\u7d20\u6297\u83cc\u8c31\u53ca\u4f5c\u7528\u4e0e\u916e\u5eb7\u5511\u76f8\u4f3c\uff0c\u4e14\u4e0d\u826f\u53cd\u5e94\u5c0f\uff0c\u56e0\u6b64\u6307\u51fa\u9752\u84bf\u7d20\u53ef\u4ee5\u5236\u6210\u5404\u79cd\u5916\u7528\u5236\u5242\u6cbb\u7597\u624b\u8db3\u7663\u7b49\u6d45\u90e8\u771f\u83cc\u611f\u67d3\uff0c\u8fd8\u53ef\u7528\u4e8e\u5934\u76ae\u5c51\u7684\u9632\u6cbb\u3002\u738b\u5b50\u89c1\u7b49<sup>[<a href=\";\">20<\/a>]<\/sup>\u6307\u51fa\uff0c\u9752\u84bf\u6325\u53d1\u6cb9\u5bf9\u591a\u79cd\u771f\u83cc\u5177\u6709\u6291\u5236\u4f5c\u7528\uff0c\u5176\u4e2d\u5bf9\u9175\u6bcd\u83cc\u53ca\u4ea7\u9ec4\u9752\u9709\u7684\u6291\u5236\u4f5c\u7528\u6700\u5f3a\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00110\">\u4e8c\u3001\u6297\u7ec6\u83cc\u4f5c\u7528<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00115\">1. \u76f8\u5173\u673a\u5236\uff1a\u674e\u5411\u9633\u7b49<sup>[<a href=\";\">21<\/a>]<\/sup>\u91c7\u7528\u9752\u84bf\u6cb9\u53ca\u9752\u84bf\u6cb9\u7eb3\u7c73\u8102\u8d28\u4f53\uff08\u4e00\u79cd\u8102\u6027\u836f\u7269\u8f7d\u4f53\uff09\u8fdb\u884c\u7814\u7a76\uff0c\u901a\u8fc7\u5236\u5907\u4e0d\u540c\u6d53\u5ea6\u7684\u9752\u84bf\u6cb9\u548c\u9752\u84bf\u6cb9\u7eb3\u7c73\u8102\u8d28\u4f53\u7684\u836f\u7269\u57f9\u517b\u6db2\uff0c\u5206\u522b\u89c2\u5bdf\u5176\u5bf9\u75e4\u75ae\u6746\u83cc\u3001\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u53ca\u7ce0\u6787\u5b62\u5b50\u83cc\u7684\u6291\u83cc\u6548\u5e94\uff0c\u7ed3\u679c\u53d1\u73b0\u4e8c\u8005\u5747\u5bf93\u79cd\u75c5\u539f\u83cc\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u6291\u5236\u4f5c\u7528\uff0c\u9752\u84bf\u6cb9\u7684\u6700\u4f4e\u6709\u6548\u6291\u83cc\u6d53\u5ea6\u4e3a6.48 mg\/L;\u9752\u84bf\u6cb9\u7eb3\u7c73\u8d28\u4f53\u7684\u6291\u83cc\u4f5c\u7528\u66f4\u5f3a\uff0c\u5176\u6700\u4f4e\u6709\u6548\u6291\u83cc\u6d53\u5ea6\u4ec50.648 mg\/L\uff0c\u4e14\u5bf9\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u3001\u7ce0\u6787\u5b62\u5b50\u83cc\u7684\u6291\u5236\u4f5c\u7528\u5c24\u4e3a\u663e\u8457\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00120\">2. \u4e34\u5e8a\u5e94\u7528\uff1a\u674e\u5a77\u7b49<sup>[<a href=\";\">22<\/a>]<\/sup>\u91c7\u7528\u53e3\u670d\u9752\u84bf\u7425\u916f\u6cbb\u7597\u8f7b\u3001\u4e2d\u5ea6\u9152\u6e23\u9f3b\uff0c\u5e76\u4e0e\u591a\u897f\u73af\u7d20\u4f5c\u5bf9\u7167\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u6cbb\u75974\u5468\u540e\uff0c\u6cbb\u7597\u7ec4\uff0831\u4f8b\uff09\u7684\u6709\u6548\u7387\u4e3a58.06%\uff0c\u5bf9\u7167\u7ec4\uff0829\u4f8b\uff09\u7684\u6709\u6548\u7387\u4e3a65.52%\uff08<em>P<\/em>&gt;0.05\uff09;2\u7ec4\u60a3\u8005\u7684\u7ea2\u6591\u3001\u4e18\u75b9\u548c\u8113\u75b1\u8bc4\u5206\u5747\u8f83\u6cbb\u7597\u524d\u5747\u660e\u663e\u4e0b\u964d\uff08<em>P<\/em>\u5747&lt;0.01\uff09\uff0c\u4f46\u6cbb\u7597\u524d\u3001\u540e\u6bdb\u7ec6\u8840\u7ba1\u6269\u5f20\u79ef\u5206\u65e0\u660e\u663e\u53d8\u5316\uff08<em>P<\/em>&gt;0.05\uff09\uff0c\u7531\u6b64\u8868\u660e\u9752\u84bf\u7425\u916f\u4e0e\u76d0\u9178\u591a\u897f\u73af\u7d20\u6cbb\u7597\u9152\u6e23\u9f3b\u6548\u679c\u76f8\u5f53\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00125\">\u4e09\u3001\u6297\u75c5\u6bd2\u4f5c\u7528<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00130\">\u6b64\u5916\uff0c\u674e\u5c0f\u96ef\u7b49<sup>[<a href=\";\">23<\/a>]<\/sup>\u5206\u6790\u6307\u51fa\uff0c\u9752\u84bf\u7425\u916f\u5bf9\u75b1\u75b9\u75c5\u6bd2\u5177\u6709\u5e7f\u6cdb\u7684\u6d3b\u6027\uff0c\u6765\u81ea\u6240\u6709\u4e9a\u79d1(A\u3001B\u548cG)\u7684\u75b1\u75b9\u75c5\u6bd2\u5bf9\u9752\u84bf\u7425\u916f\u5747\u654f\u611f\uff0c\u5982EB\u75c5\u6bd2\u3001\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd21\u548c\u4eba\u7c7b\u75b1\u75b9\u75c5\u6bd26A\u3002\u9752\u84bf\u7425\u916f\u6297\u75b1\u75b9\u75c5\u6bd2\u7684\u6d3b\u6027\u56e0\u75c5\u6bd2\u79cd\u7c7b\u4e0d\u540c\u800c\u7565\u6709\u5dee\u5f02\uff0c\u4f46\u5176\u6297\u75c5\u6bd2\u673a\u5236\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<h2 class=\"wp-block-heading\" id=\"outline_anchor_3\">\u9752\u84bf\u884d\u751f\u7269\u4e0e\u76ae\u80a4\u80bf\u7624<\/h2>\n<p class=\"wp-block-paragraph\" id=\"p00140\">\u9752\u84bf\u884d\u751f\u7269\u5bf9\u591a\u79cd\u80bf\u7624\u7ec6\u80de\u5177\u6709\u7279\u5f02\u6740\u4f24\u4f5c\u7528\uff0c\u80fd\u591f\u660e\u663e\u6291\u5236\u80c3\u80a0\u9053\u80bf\u7624\u3001\u5375\u5de2\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96\u5e76\u8bf1\u5bfc\u5176\u51cb\u4ea1\uff0c\u4f5c\u7528\u673a\u5236\u53ef\u80fd\u4e0e\u542f\u52a8\u5185\u6e90\u6027\u7ebf\u7c92\u4f53\u51cb\u4ea1\u9014\u5f84\uff0c\u589e\u9ad8\u5154\u6297\u4eba\u5355\u514b\u9686\u6297\u4f53Bax\u3001caspase-9\u53cacaspase-3\u86cb\u767d\u8868\u8fbe\uff0c\u964d\u4f4eBcl-2\u86cb\u767d\u8868\u8fbe\u7b49\u6709\u5173\u3002\u8fd9\u79cd\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\u540c\u6837\u9002\u7528\u4e8e\u76ae\u80a4\u80bf\u7624\u3002\u76ee\u524d\u5df2\u6709\u9488\u5bf9\u76ae\u80a4\u6dcb\u5df4\u7624\u3001\u8868\u76ae\u80bf\u7624\u7b49\u7684\u76f8\u5173\u7814\u7a76\u3002\u5f20\u828a\u7b49<sup>[<a href=\";\">24<\/a>]<\/sup>\u91c7\u7528\u4e0d\u540c\u6d53\u5ea6\u7684\u53cc\u6c22\u9752\u84bf\u7d20\uff0c\u5355\u72ec\u6216\u8054\u5408\u7532\u6c28\u8776\u5464\uff08methotrexate, MTX\uff09\u5904\u7406\u76ae\u80a4T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08cutaneous T cell lymphoma, CTCL\uff09\u7684\u7ec6\u80de\uff0c\u5728\u4e0d\u540c\u65f6\u6bb5\u68c0\u6d4b\u7ec6\u80de\u7684\u751f\u5b58\u7387\u3001\u7ec6\u80de\u5468\u671f\u3001\u7ec6\u80de\u51cb\u4ea1\u60c5\u51b5\uff0c\u5e76\u68c0\u6d4b\u5904\u7406\u7ec6\u80de48 h\u540e\u51cb\u4ea1\u76f8\u5173\u57fa\u56e0\u548cDNA\u635f\u4f24\u76f8\u5173\u57fa\u56e0\u7684\u86cb\u767d\u8868\u8fbe\u3002\u7ed3\u679c\u663e\u793a\uff0c\u53cc\u6c22\u9752\u84bf\u7d20\u901a\u8fc7\u6291\u5236\u7ec6\u80de\u589e\u6b96\u548c\u4fc3\u8fdb\u7ec6\u80de\u51cb\u4ea1\u6765\u6291\u5236CTCL\u7ec6\u80de\u7cfb\u751f\u957f\uff0c\u8054\u5408MTX\u80fd\u660e\u663e\u63d0\u9ad8\u6291\u5236CTCL\u7ec6\u80de\u7684\u751f\u957f\u7387\u3002\u6c5f\u5fe0\u52c7\u7b49<sup>[<a href=\";\">25<\/a>]<\/sup>\u901a\u8fc7\u68c0\u6d4b\u9752\u84bf\u7425\u916f\u4f5c\u7528\u540e\u4eba\u8868\u76ae\u9cde\u764c\u7ec6\u80deA431\u7ec6\u80de\u7684\u7ec6\u80de\u51cb\u4ea1\u7387\uff0c\u4ee5\u53ca\u7ec6\u80de\u5468\u671f\u76f8\u5173\u56e0\u5b50\u7684\u524d\u540e\u53d8\u5316\uff0c\u53d1\u73b0\u9752\u84bf\u7425\u916f\u5bf9\u76ae\u80a4\u764c\u7ec6\u80deA431\u7ec6\u80de\u5177\u6709\u7279\u5f02\u6027\u7684\u751f\u957f\u6291\u5236\u4f5c\u7528\uff0c\u8fd9\u79cd\u4f5c\u7528\u4e3b\u8981\u662f\u901a\u8fc7\u4fc3\u8fdb\u764c\u7ec6\u80deA431\u51cb\u4ea1\u548c\u574f\u6b7b\uff0c\u4ee5\u53ca\u8c03\u63a7\u76f8\u5173\u5468\u671f\u86cb\u767d\u53d8\u5316\u5f15\u8d77\u5468\u671f\u505c\u6ede\u800c\u53d1\u6325\u4f5c\u7528\u7684\u3002\u590f\u59e3\u5a25\u7b49<sup>[<a href=\";\">26<\/a>]<\/sup>\u7814\u7a76\u9752\u84bf\u7425\u916f\u8054\u5408\u987a\u94c2\u6cbb\u7597\u5c0f\u9f20\u6076\u6027\u9ed1\u7d20\u7624\uff0c\u7ed3\u679c\u53d1\u73b0\u9752\u84bf\u7425\u916f\u5bf9\u9ed1\u8272\u7d20\u7624B16F0\u7ec6\u80de\u5177\u6709\u6740\u4f24\u4f5c\u7528\uff0c\u5e76\u5448\u5242\u91cf\u4f9d\u8d56\u6548\u5e94\uff0c\u4f4e\u6d53\u5ea6\u9752\u84bf\u7425\u916f\u5728\u4f53\u5185\u5916\u53ef\u534f\u540c\u589e\u5f3a\u987a\u94c2\u5bf9B16F0\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00145\">\u6b64\u5916\uff0c\u4f53\u5185\u5916\u7814\u7a76\u8fd8\u8868\u660e\uff0c\u9752\u84bf\u53ca\u5176\u884d\u751f\u7269\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u7ec6\u80de\u4fb5\u88ad\u8fc1\u79fb\u3001\u6c27\u5316\u635f\u4f24\u3001\u963b\u65ad\u7ec6\u80de\u4fe1\u53f7\u8f6c\u5bfc\u3001\u6291\u5236\u8840\u7ba1\u751f\u6210\u7b49\u9014\u5f84\uff0c\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528<sup>[<a href=\";\">27<\/a>&#8211;<a href=\";\">28<\/a>]<\/sup>\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u5e94\u7528\u76ee\u524d\u9752\u84bf\u884d\u751f\u7269\u5bf9\u76ae\u80a4\u80bf\u7624\u7684\u6cbb\u7597\u5c1a\u5c40\u9650\u5728\u57fa\u7840\u7814\u7a76\u6216\u52a8\u7269\u7814\u7a76\uff0c\u5c1a\u672a\u67e5\u5230\u5728\u4e34\u5e8a\u5e94\u7528\u7684\u6587\u732e\u62a5\u9053\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<h2 class=\"wp-block-heading\" id=\"outline_anchor_4\">\u9752\u84bf\u884d\u751f\u7269\u4e0e\u7622\u75d5\u589e\u751f<\/h2>\n<p class=\"wp-block-paragraph\" id=\"p00160\">\u7814\u7a76\u663e\u793a\uff0c\u9752\u84bf\u884d\u751f\u7269\u4e0d\u4ec5\u5bf9\u76ae\u80a4\u80bf\u7624\u6709\u6291\u5236\u4f5c\u7528\uff0c\u5bf9\u7622\u75d5\u7ec4\u7ec7\u7684\u589e\u751f\u4e5f\u6709\u6291\u5236\u4f5c\u7528\u3002\u79cd\u79cd\u7814\u7a76\u8868\u660e\uff0c\u9752\u84bf\u884d\u751f\u7269\u5bf9\u7622\u75d5\u7ec4\u7ec7\u7684\u5f62\u6210\u5177\u6709\u4e00\u5b9a\u6291\u5236\u4f5c\u7528\uff0c\u5176\u6291\u5236\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u751f\u957f\uff0c\u4f7f\u80f6\u539f\u51cf\u5c11\uff0c\u8d77\u5230\u6297\u76ae\u80a4\u7622\u75d5\u7684\u4f5c\u7528\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00165\">\u4e00\u3001\u76f8\u5173\u673a\u5236<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00170\">\u674e\u6218\u7b49<sup>[<a href=\";\">29<\/a>]<\/sup>\u7528\u5404\u6d53\u5ea6\u7684\u9752\u84bf\u7425\u916f\u4f5c\u7528\u4e8e\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u4e4b\u540e\u5206\u522b\u91c7\u7528\u8367\u5149\u5b9a\u91cfRT-PCR\u6cd5\u68c0\u6d4b\u53d1\u73b0\u4eba\u76ae\u80a4\u589e\u751f\u6027\u7622\u75d5\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684Smad3 mRNA\u8868\u8fbe\u4e0b\u8c03\uff0c\u4e0e\u7a7a\u767d\u5bf9\u7167\u7ec4\u6bd4\u8f83,\u5dee\u5f02\u5747\u6709\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08<em>P<\/em>&lt;0.01\uff09;\u86cb\u767d\u5370\u8ff9\u6cd5\u68c0\u6d4b\u53d1\u73b0\u5404\u9752\u84bf\u7425\u916f\u4f5c\u7528\u5e72\u9884\u7ec4Smad3\u86cb\u767d\u8868\u8fbe\u4e0b\u8c03\uff0c\u4e0e\u7a7a\u767d\u5bf9\u7167\u7ec4\u6bd4\u8f83\uff0c\u5dee\u5f02\u5747\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08<em>P<\/em>&lt;0.01\uff09\uff0c\u8868\u660e\u9752\u84bf\u7425\u916f\u53ef\u4e0b\u8c03\u4eba\u76ae\u80a4\u589e\u751f\u6027\u7622\u75d5\u6210\u7ea4\u7ef4\u7ec6\u80deSmad3\u7684mRNA\u53ca\u86cb\u767d\u6c34\u5e73\uff0c\u6291\u5236Smad3\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u51cf\u5c11\u80f6\u539f\u5408\u6210\uff0c\u8fd9\u53ef\u80fd\u662f\u9752\u84bf\u7425\u916f\u6291\u5236\u589e\u751f\u6027\u7622\u75d5\u7684\u673a\u5236\u3002\u6c5f\u5ddd\u7b49<sup>[<a href=\";\">30<\/a>]<\/sup>\u752860 mg\/L\u9752\u84bf\u7425\u916f\u4f5c\u7528\u4e8e\u4f53\u5916\u57f9\u517b\u7684\u7622\u75d5\u7599\u7629\u6210\u7ea4\u7ef4\u7ec6\u80de24 h\uff0c\u901a\u8fc7\u68c0\u6d4b\u540e\u53d1\u73b0\u5206\u5316\u6291\u5236\u56e0\u5b501\u4e0b\u964d\u3002\u4ed6\u4eec\u6307\u51fa\u9752\u84bf\u7425\u916f\u6291\u5236\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u4f5c\u7528\u5728\u4e8e\u6291\u5236\u5206\u5316\u6291\u5236\u56e0\u5b501\u3002\u6768\u4eca\u8a00\u7b49<sup>[<a href=\";\">31<\/a>]<\/sup>\u7528\u65b0\u897f\u5170\u5927\u8033\u767d\u5154\u5efa\u7acb\u4e86\u5154\u8033\u589e\u751f\u6027\u7622\u75d5\u7684\u6a21\u578b\uff0c\u901a\u8fc7\u751f\u7406\u76d0\u6c34\u5bf9\u7167\u6bd4\u8f83\u4e8c\u6c22\u9752\u84bf\u7d20\u5bf9\u589e\u751f\u6027\u7622\u75d5\u7684\u5f71\u54cd\uff0c\u7ed3\u679c\u53d1\u73b0\u704c\u80c3\u6ce8\u5165\u4e8c\u6c22\u9752\u84bf\u7d20\u7684\u5154\u8033\u7622\u75d5\u53d1\u751f\u7387\uff0830%\uff09\u663e\u8457\u5c11\u4e8e\u6ce8\u5165\u751f\u7406\u76d0\u6c34\uff08100%\uff09\u7684;\u5b9e\u9a8c\u7ec4\u4ea7\u751f\u7622\u75d5\u660e\u663e\u5c0f\u4e8e\u5bf9\u7167\u7ec4\uff08\u7622\u75d5\u22651 m<sup>3<\/sup>\u7684\u53d1\u751f\u7387\uff0c\u5bf9\u7167\u7ec4\u4e3a90%\uff0c\u5b9e\u9a8c\u7ec4\u4e3a0%\uff09\uff0c\u63d0\u793a\u4e8c\u6c22\u9752\u84bf\u7d20\u53ef\u80fd\u53ef\u964d\u4f4e\u5154\u8033\u7622\u75d5\u7684\u53d1\u751f\uff0c\u5e76\u5f71\u54cd\u7622\u75d5\u5f62\u6210\u7684\u5927\u5c0f\u3002<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00175\">\u4e8c\u3001\u4e34\u5e8a\u5e94\u7528<\/p>\n<p class=\"wp-block-paragraph\" id=\"p00180\">\u6709\u7814\u7a76\u8005\u968f\u673a\u9009\u53d6\u4e8690\u4f8b\u589e\u751f\u6027\u7622\u75d5\u589e\u6b96\u671f\u7684\u60a3\u8005\uff0c\u4e88\u4ee5\u5916\u7528\u9752\u84bf\u7425\u916f\u971c\u5242\uff0c\u6bcf\u65e5\u76ae\u635f\u59041~2\u6b21\uff0c\u7597\u7a0b2~3\u4e2a\u6708\uff0c\u7ed3\u679c\u603b\u6709\u6548\u7387\u4e3a91.1%\uff0c\u5176\u4e2d\u5b8c\u5168\u7f13\u89e3\u8005\u536040.0%\uff0c\u6781\u5927\u7f13\u89e3\u8005\u536051.1%\uff0c\u90e8\u5206\u7f13\u89e3\u8005\u53608.8%<sup>[<a href=\";\">32<\/a>]<\/sup>\uff0c\u7531\u6b64\u63d0\u51fa\u9752\u84bf\u7425\u916f\u971c\u5242\u6cbb\u7597\u589e\u751f\u6027\u7622\u75d5\u7684\u7597\u6548\u663e\u8457\u3002<\/p>\n<h2 class=\"wp-block-heading\" id=\"outline_anchor_5\">\u7ed3\u8bed<\/h2>\n<p class=\"wp-block-paragraph\" id=\"p00190\">\u4e2d\u56fd\u836f\u5b66\u5bb6\u5c60\u5466\u5466\u63a8\u6d4b\uff0c\u63d0\u53d6\u9752\u84bf\u6709\u6548\u6210\u5206\u4e0d\u5b9c\u7528\u52a0\u70ed\u65b9\u6cd5\uff0c\u9ad8\u6e29\u53ef\u80fd\u4f7f\u6d3b\u6027\u6210\u5206\u53d7\u635f\uff0c\u56e0\u800c\u6539\u7528\u6cb8\u70b9\u53ea\u670935 \u2103\u7684\u4e59\u919a\u4f5c\u4e3a\u6eb6\u5242\u6765\u63d0\u53d6\u9752\u84bf\u7d20\uff0c\u521b\u5236\u51fa\u6211\u56fd\u7b2c\u4e00\u4e2a\u81ea\u884c\u7814\u5236\u7684\u836f\u7269\u2014\u2014\u65b0\u578b\u6297\u759f\u836f\u9752\u84bf\u7d20\u548c\u53cc\u6c22\u9752\u84bf\u7d20\uff0c\u4e3a\u6b64\u83b7\u5f97\u4e862015\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\uff0c\u7531\u6b64\u4e5f\u5f15\u53d1\u4e86\u4e00\u80a1\u7814\u7a76\u9752\u84bf\u53ca\u5176\u884d\u751f\u7269\u7684\u70ed\u6f6e\u3002\u76ee\u524d\u4f17\u591a\u7684\u57fa\u7840\u548c\u4e34\u5e8a\u7814\u7a76\u5747\u663e\u793a\uff0c\u9752\u84bf\u53ca\u5176\u884d\u751f\u7269\u5728\u81ea\u8eab\u514d\u75ab\u6027\u3001\u611f\u67d3\u6027\u3001\u80bf\u7624\u6027\u53ca\u7622\u75d5\u589e\u751f\u6027\u7b49\u76ae\u80a4\u75c5\u9886\u57df\u6709\u7740\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002\u4f46\u76ee\u524d\u7684\u7814\u7a76\u7279\u522b\u662f\u4e34\u5e8a\u7814\u7a76\u4e25\u91cd\u4e0d\u8db3\uff0c\u5df2\u6709\u7684\u4e5f\u8fd8\u5b58\u5728\u7740\u65b9\u6848\u8bbe\u8ba1\u4e0d\u4e25\u8c28\u3001\u6837\u672c\u91cf\u5c0f\u7b49\u4e0d\u5c11\u7f3a\u9677\uff0c\u9ad8\u8d28\u91cf\u7684\u6587\u732e\u4e0d\u591a\uff0c\u8fd8\u6709\u5f85\u8fdb\u4e00\u6b65\u6df1\u5165\u3001\u89c4\u8303\u5730\u5f00\u5c55\u7b26\u5408\u5faa\u8bc1\u533b\u5b66\u8981\u6c42\u7684\u7814\u7a76\u3002<\/p>\n<h2 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class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[194],"class_list":["post-67446","post","type-post","status-publish","format-standard","hentry","category-70","tag-194"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/67446","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=67446"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/67446\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=67446"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=67446"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=67446"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}