{"id":67396,"date":"2026-08-20T07:54:44","date_gmt":"2026-08-20T07:54:44","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=67396"},"modified":"2026-08-20T07:54:44","modified_gmt":"2026-08-20T07:54:44","slug":"%e4%b8%ad%e5%9b%bd%e5%8c%bb%e5%ad%a6%e7%a7%91%e5%ad%a6%e9%99%a2%e8%92%8b%e5%bb%ba%e4%b8%9c%e5%92%8c%e7%8e%8b%e7%90%b0%e7%ad%89%e5%9b%a2%e9%98%9f%ef%bc%9a%e5%b0%8f%e6%aa%97%e7%a2%b1%e9%80%9a%e8%bf%87","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=67396","title":{"rendered":"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f AMPD2 \u6d3b\u6027\uff0c\u63ed\u793a\u5c0f\u6a97\u78b1\u6539\u5584\u9ad8\u5c3f\u9178\u8840\u75c7\u7684\u673a\u5236"},"content":{"rendered":"

\u533b\u7814\u4e09\u4eba\u884c<\/a>2025\u5e748\u670829\u65e5 <\/em><\/p>\n

\u5404\u4f4d\u70ed\u7231\u79d1\u7814\u7684\u5c0f\u4f19\u4f34\u4eec\uff0c\u4eca\u5929\u4e3a\u5927\u5bb6\u63a8\u4ecb\u53d1\u8868\u5728\u300aActa Pharmaceutica Sinica B\u300b\u6742\u5fd7\u7684\u7814\u7a76\u6027\u6587\u7ae0\u3002\u8be5\u6587\u7ae0\u7531\u4e2d\u56fd\u5de5\u7a0b\u9662\u9662\u58eb\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u836f\u7269\u7814\u7a76\u9662\u9662\u957f \u848b\u5efa\u4e1c\u548c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u836f\u7269\u7814\u7a76\u6240\u836f\u4ee3\u5ba4\u4e3b\u4efb\u738b\u7430<\/strong>\u56e2\u961f\u5b8c\u6210\uff0c\u4e3b\u8981\u4ece\u4e8b\u6297\u75c5\u6bd2\u3001\u6297\u4ee3\u8c22\u6027\u75be\u75c5\u548c\u6297\u80bf\u7624\u7684\u65b0\u836f\u7814\u7a76\uff1b\u836f\u7269\u4ee3\u8c22\u3001\u836f\u52a8\u5b66\u4e0e\u836f\u7269\u5206\u6790\u7814\u7a76\u3002\u6587\u7ae0\u9898\u4e3a\u201cBacteroides fragilis-derived succinic acid promotes the degradation of uric acid by inhibiting hepatic AMPD2: Insight into how plant-based berberine ameliorates hyperuricemia\u201d\u3002\u672c\u6587\u62a5\u9053\u4e86\u9996\u6b21\u63ed\u793a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u8106\u5f31\u62df\u6746\u83cc\u6765\u6e90\u7684\u7425\u73c0\u9178\uff0c\u8fdb\u800c\u6291\u5236\u809d\u810f AMPD2 \u6d3b\u6027\uff0c\u4ece\u800c\u963b\u65ad\u5c3f\u9178\u5408\u6210\u5e76\u964d\u4f4e\u8840\u5c3f\u9178\uff0c\u4e3a\u9ad8\u5c3f\u9178\u8840\u75c7\u63d0\u4f9b\u4e86\u5168\u65b0\u201c\u80a0-\u809d\u8f74\u201d\u6cbb\u7597\u673a\u5236\u4e0e\u5019\u9009\u836f\u7269\uff0c\u5e76\u4e14\u56f4\u7ed5\uff1a\u5c0f\u6a97\u78b1\uff1b\u9ad8\u5c3f\u9178\u8840\u75c7\uff1b\u80a0\u9053\u83cc\u7fa4\uff1bAMPD2\uff1b\u7425\u73c0\u9178\uff1b\u5c3f\u9178\u5408\u6210\uff1b\u80a0-\u809d\u8f74\uff1b\u8106\u5f31\u62df\u6746\u83cc\u7b49\u5173\u952e\u8bcd\u5c55\u5f00\u7814\u7a76\u3002https:\/\/wxa.wxs.qq.com\/tmpl\/pl\/base_tmpl.html<\/p>\n

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\n

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\u7425\u73c0\u9178\uff08Succinic acid\uff09\uff1a\u8106\u5f31\u62df\u6746\u83cc\uff08\u6709\u76ca\u83cc\uff09\u7684\u4ee3\u8c22\u4ea7\u7269\uff0c\u53ef\u901a\u8fc7\u63d0\u9ad8\u78f7\u9178\u76d0\u6c34\u5e73\u6291\u5236 AMPD2\uff0c\u662f\u8fde\u63a5\u80a0\u9053\u83cc\u7fa4\u4e0e\u809d\u810f\u5c3f\u9178\u5408\u6210\u7684\u5173\u952e\u4ee3\u8c22\u7269\u3002<\/p>\n

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3. \u4e34\u5e8a\u7814\u7a76\uff1a\u7eb3\u516522\u540d\u53d7\u8bd5\u8005\uff088\u4f8b\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u300114\u4f8b\u975e\u9ad8\u5c3f\u9178\u8840\u75c7\u5fd7\u613f\u8005\uff0c\u5747\u5408\u5e76\u9ad8\u8102\u8840\u75c7\uff09\uff0c\u53e3\u670d\u5c0f\u6a97\u78b1\uff080.5 g\uff0c\u6bcf\u65e52\u6b21\uff09\u5e72\u98846\u4e2a\u6708\uff0c\u5b9a\u671f\u68c0\u6d4b\u8840\u5c3f\u9178\u3001\u8840\u808c\u9150\u3001\u8840\u5c3f\u7d20\u6c2e\uff08BUN\uff09\u6c34\u5e73\uff0c\u901a\u8fc716S rRNA\u57fa\u56e0\u6d4b\u5e8f\u5206\u6790\u7caa\u4fbf\u80a0\u9053\u83cc\u7fa4\u7ec4\u6210\uff08\u62df\u6746\u83cc\u3001\u4e25\u683c\u68ad\u83cc1\u578b\u7b49\uff09\uff0c\u5e76\u8fdb\u884c\u83cc\u7fa4\u4e30\u5ea6\u4e0e\u5c3f\u9178\u6c34\u5e73\u7684\u76f8\u5173\u6027\u5206\u6790\u3002<\/p>\n

4. \u5fae\u751f\u7269\u5b9e\u9a8c\uff1a\u57f9\u517b\u8106\u5f31\u62df\u6746\u83cc\uff08ATCC 25285\uff09\uff0c\u901a\u8fc7\u7caa\u83cc\u79fb\u690d\u5b9e\u9a8c\u9a8c\u8bc1\u5176\u5bf9\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u5c0f\u9f20\u5c3f\u9178\u6c34\u5e73\u7684\u5f71\u54cd\uff0c\u6c14\u76f8\u8272\u8c31\uff08GC\uff09\u68c0\u6d4b\u7caa\u4fbf\u4e2d\u77ed\u94fe\u8102\u80aa\u9178\uff08\u7425\u73c0\u9178\u3001\u4e19\u9178\uff09\u542b\u91cf\u3002<\/p>\n

\u7ed3\u679c<\/strong>\uff1a1. \u5c0f\u6a97\u78b1\u7684\u964d\u5c3f\u9178\u4f5c\u7528\uff1a\u5728\u6162\u6027\/\u6025\u6027\u9ad8\u5c3f\u9178\u8840\u75c7\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u5c0f\u6a97\u78b1\u5448\u65f6\u95f4\u548c\u5242\u91cf\u4f9d\u8d56\u6027\u964d\u4f4e\u8840\u5c3f\u9178\u6c34\u5e73\uff08\u9ad8\u5242\u91cf\u7ec42\u5468\u5185\u5c3f\u9178\u964d\u4f4e54%\uff09\uff0c\u6548\u679c\u4e0e\u9633\u6027\u836f\u82ef\u6eb4\u9a6c\u9686\u76f8\u5f53\uff1b\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c22\u540d\u53d7\u8bd5\u8005\u5e72\u98846\u4e2a\u6708\u540e\u8840\u5c3f\u9178\u5e73\u5747\u964d\u4f4e11.34%\uff0c\u5176\u4e2d\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u964d\u4f4e11.00%\uff0c\u975e\u9ad8\u5c3f\u9178\u8840\u75c7\u5fd7\u613f\u8005\u964d\u4f4e12.70%\u3002<\/p>\n

2. \u5c0f\u6a97\u78b1\u5bf9\u80a0\u9053\u83cc\u7fa4\u7684\u8c03\u63a7\uff1a\u52a8\u7269\u6a21\u578b\u548c\u4e34\u5e8a\u6837\u672c\u5747\u663e\u793a\uff0c\u5c0f\u6a97\u78b1\u53ef\u63d0\u9ad8\u62df\u6746\u83cc\u4e30\u5ea6\uff08\u60a3\u8005\u7ec4\u5e72\u9884\u540e\u62df\u6746\u83cc\u4e30\u5ea6\u589e\u52a0268%\uff09\u3001\u964d\u4f4e\u4e25\u683c\u68ad\u83cc1\u578b\u4e30\u5ea6\uff1b\u76f8\u5173\u6027\u5206\u6790\u8868\u660e\uff0c\u62df\u6746\u83cc\u4e30\u5ea6\u4e0e\u8840\u5c3f\u9178\u5448\u663e\u8457\u8d1f\u76f8\u5173\uff08R\u00b2=0.3046\uff0cP=0.077\uff09\uff0c\u4e25\u683c\u68ad\u83cc1\u578b\u4e30\u5ea6\u4e0e\u8840\u5c3f\u9178\u5448\u663e\u8457\u6b63\u76f8\u5173\uff08R\u00b2=0.2719\uff0cP=0.0128\uff09\u3002<\/p>\n

3. \u8106\u5f31\u62df\u6746\u83cc\u53ca\u7425\u73c0\u9178\u7684\u4f5c\u7528\uff1a\u8106\u5f31\u62df\u6746\u83cc\u79fb\u690d\u53ef\u663e\u8457\u964d\u4f4e\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u5c0f\u9f20\u8840\u5c3f\u9178\u6c34\u5e73\uff0c\u540c\u65f6\u589e\u52a0\u7caa\u4fbf\u7425\u73c0\u9178\u542b\u91cf\uff1b\u7425\u73c0\u9178\u94a0\u5e72\u9884\u53ef\u964d\u4f4e\u6a21\u578b\u52a8\u7269\u8840\u5c3f\u9178\uff0c\u6291\u5236\u809d\u810fAMPD2\u6d3b\u6027\uff08\u51cf\u5c11AMP\u5411IMP\u8f6c\u5316\uff09\uff0c\u964d\u4f4e\u4e0b\u6e38\u6b21\u9ec4\u560c\u5464\u3001\u9ec4\u560c\u5464\u751f\u6210\uff0c\u4e14\u5728\u7ec6\u80de\u5b9e\u9a8c\u4e2d\u53ef\u6062\u590d\u679c\u7cd6\u8bf1\u5bfc\u7684\u78f7\u9178\u76d0\u6d88\u8017\uff0c\u9006\u8f6cATP\u5f02\u5e38\u5347\u9ad8\u3002<\/p>\n

4. \u5c0f\u6a97\u78b1\u7684\u80be\u810f\u4fdd\u62a4\u4f5c\u7528\uff1a\u9ad8\u5c3f\u9178\u8840\u75c7\u80be\u75c5\u5927\u9f20\u6a21\u578b\u4e2d\uff0c\u5c0f\u6a97\u78b1\u53ef\u964d\u4f4e\u8840\u808c\u9150\u3001BUN\u53ca\u6c27\u5316\u4e09\u7532\u80fa\uff08TMAO\uff09\u6c34\u5e73\uff0c\u51cf\u8f7b\u80be\u810f\u7a7a\u6ce1\u53d8\u6027\u53ca\u5c3f\u9178\u76d0\u7ed3\u6676\u6c89\u79ef\uff0c\u6548\u679c\u4f18\u4e8e\u9633\u6027\u836f\u975e\u5e03\u53f8\u4ed6\u3002<\/p>\n

\u7ed3\u8bba<\/strong>\uff1a\u5c0f\u6a97\u78b1\u53ef\u901a\u8fc7\u201c\u80a0-\u809d\u8f74\u201d\u6539\u5584\u9ad8\u5c3f\u9178\u8840\u75c7\uff1a\u4e00\u65b9\u9762\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\uff08\u5347\u9ad8\u62df\u6746\u83cc\u3001\u964d\u4f4e\u4e25\u683c\u68ad\u83cc1\u578b\uff09\uff0c\u4fc3\u8fdb\u62df\u6746\u83cc\u4ea7\u751f\u7425\u73c0\u9178\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u7425\u73c0\u9178\u901a\u8fc7\u63d0\u9ad8\u809d\u7ec6\u80de\u78f7\u9178\u76d0\u6c34\u5e73\uff08AMPD2\u5185\u6e90\u6027\u6291\u5236\u5242\uff09\uff0c\u6291\u5236\u809d\u810fAMPD2\u6d3b\u6027\uff0c\u51cf\u5c11\u560c\u5464\u4ee3\u8c22\u901a\u8def\u4e2d\u5c3f\u9178\u7684\u751f\u6210\u3002\u6b64\u5916\uff0c\u5c0f\u6a97\u78b1\u8fd8\u5177\u6709\u826f\u597d\u7684\u80be\u810f\u4fdd\u62a4\u4f5c\u7528\uff0c\u662f\u6cbb\u7597\u9ad8\u5c3f\u9178\u8840\u75c7\u7684\u6f5c\u5728\u6709\u6548\u836f\u7269\u3002<\/p>\n

\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f<\/figure>\n

\u56fe\u5f62\u6458\u8981<\/p>\n

\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f<\/figure>\n

\u56fe1 \u5c0f\u6a97\u78b1\uff08BBR\uff09\u663e\u8457\u6539\u5584ICR\u5c0f\u9f20\u6162\u6027\/\u6025\u6027\u9ad8\u5c3f\u9178\u8840\u75c7<\/p>\n

(A) \u9ad8\u560c\u5464\u996e\u98df\u8bf1\u5bfc\u6162\u6027\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u7684\u5b9e\u9a8c\u5206\u7ec4\u53ca\u65b9\u6848\u3002(B) \u6cbb\u75971\u5468\uff08\u5de6\uff09\u548c2\u5468\uff08\u53f3\uff09\u540e\u7684\u8840\u6d46\u5c3f\u9178\u6c34\u5e73\uff08n=10\uff09\u3002(C) \u9ec4\u560c\u5464\u8bf1\u5bfc\u6025\u6027\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u7684\u5b9e\u9a8c\u5206\u7ec4\u53ca\u65b9\u6848\u3002(D) \u9ec4\u560c\u5464\u8bf1\u5bfc\u6a21\u578b\u4e2d\u52a8\u7269\u7684\u8840\u6d46\u5c3f\u9178\u6c34\u5e73\uff08\u5bf9\u7167\u7ec4\uff1an=7\uff1b\u6a21\u578b\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1100 mg\/kg\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=8\uff1b\u82ef\u6eb4\u9a6c\u9686\u7ec4\uff1an=8\uff09\u3002(E) \u9ec4\u560c\u5464\u8bf1\u5bfc\u6a21\u578b\u4e2d\u52a8\u7269\u7684\u80be\u91cd\/\u4f53\u91cd\u6bd4\u503c\uff08\u5bf9\u7167\u7ec4\uff1an=10\uff1b\u6a21\u578b\u7ec4\uff1an=11\uff1b\u5c0f\u6a97\u78b1100 mg\/kg\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=10\uff1b\u82ef\u6eb4\u9a6c\u9686\u7ec4\uff1an=10\uff09\u3002(F) \u9ec4\u560c\u5464\u8bf1\u5bfc\u6a21\u578b\u4e2d\u52a8\u7269\u7684\u8840\u6d46\u808c\u9150\u6c34\u5e73\uff08n=6\uff09\u3002(G\u3001H) \u5c0f\u6a97\u78b1\u5355\u6b21\u53e3\u670d\u7ed9\u836f\u7ec4\u7684\u5b9e\u9a8c\u5206\u7ec4\u53ca\u65b9\u6848\uff08G\uff09\u548c\u8840\u6d46\u5c3f\u9178\u6c34\u5e73\uff08n=5\uff09\uff08H\uff09\u3002(I) \u5c0f\u6a97\u78b1\u591a\u6b21\u53e3\u670d\u7ed9\u836f\u540e\u8840\u6d46\u6b21\u9ec4\u560c\u5464\u6c34\u5e73\uff08n=6\uff09\u3002(J) \u5c0f\u6a97\u78b1\u591a\u6b21\u53e3\u670d\u7ed9\u836f\u540e\u8840\u6d46\u5c3f\u9178\u6c34\u5e73\uff08n=6\uff09\u3002<\/p>\n

\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f<\/figure>\n

\u56fe2 \u5c0f\u6a97\u78b1\uff08BBR\uff09\u6539\u53d8\u6162\u6027\u9ad8\u5c3f\u9178\u8840\u75c7\u52a8\u7269\u6a21\u578b\u7684\u80a0\u9053\u83cc\u7fa4\u7ec4\u6210<\/p>\n

(A) \u5bf9\u7167\u7ec4\u4e0e\u6a21\u578b\u7ec4\uff08\u5de6\uff09\u3001\u6a21\u578b\u7ec4\u4e0e\u5c0f\u6a97\u78b1\u7ec4\uff08\u53f3\uff09\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u5dee\u5f02\u3002(B) \u95e8\u6c34\u5e73\u80a0\u9053\u83cc\u7fa4\u7684\u7ec4\u6210\u5dee\u5f02\u3002(C) \u75a3\u5fae\u83cc\u95e8\uff08Verrucomicrobia\uff09\u76f8\u5bf9\u4e30\u5ea6\u7684\u53d8\u5316\u3002(D) \u653e\u7ebf\u83cc\u95e8\uff08Actinobacteria\uff09\u76f8\u5bf9\u4e30\u5ea6\u7684\u53d8\u5316\u3002(E) \u5c5e\u6c34\u5e73\u80a0\u9053\u83cc\u7fa4\u7684\u70ed\u56fe\u5206\u6790\u3002(F) \u79d1\u91ccobacteriaceae_UCG-002\u5c5e\u76f8\u5bf9\u4e30\u5ea6\u7684\u53d8\u5316\u3002(G) \u62df\u6746\u83cc\u5c5e\uff08Bacteroides\uff09\u76f8\u5bf9\u4e30\u5ea6\u7684\u53d8\u5316\u3002<\/p>\n

\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f<\/figure>\n

\u56fe3 \u5c0f\u6a97\u78b1\uff08BBR\uff09\u6539\u53d8\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u7684\u80a0\u9053\u83cc\u7fa4\u7ec4\u6210<\/p>\n

(A) 22\u540d\u53d7\u8bd5\u8005\u63a5\u53d7\u5c0f\u6a97\u78b1\u6cbb\u75972\u30014\u30016\u4e2a\u6708\u540e\u7684\u5c3f\u9178\u6c34\u5e73\u3002(B) 8\u540d\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u7684\u5c3f\u9178\u6c34\u5e73\u3002(C) 14\u540d\u975e\u9ad8\u5c3f\u9178\u8840\u75c7\u5fd7\u613f\u8005\u7684\u5c3f\u9178\u6c34\u5e73\u3002(D) 22\u540d\u53d7\u8bd5\u8005\u63a5\u53d7\u5c0f\u6a97\u78b1\u6cbb\u75972\u30014\u30016\u4e2a\u6708\u540e\u7684\u808c\u9150\u6c34\u5e73\u3002(E) 22\u540d\u53d7\u8bd5\u8005\u63a5\u53d7\u5c0f\u6a97\u78b1\u6cbb\u75972\u30014\u30016\u4e2a\u6708\u540e\u7684\u8840\u5c3f\u7d20\u6c2e\uff08BUN\uff09\u6c34\u5e73\u3002(F) \u5165\u7ec4\u65f6\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u4e0e\u975e\u9ad8\u5c3f\u9178\u8840\u75c7\u5fd7\u613f\u8005\u7684\u62df\u6746\u83cc\u5c5e\uff08Bacteroides\uff09\u4e30\u5ea6\u3002(G) \u5165\u7ec4\u65f6\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u4e0e\u975e\u9ad8\u5c3f\u9178\u8840\u75c7\u5fd7\u613f\u8005\u7684\u4e25\u683c\u68ad\u83cc1\u578b\uff08Clostridium_sensu_stricto_1\uff09\u4e30\u5ea6\u3002(H) \u975e\u9ad8\u5c3f\u9178\u8840\u75c7\u5fd7\u613f\u8005\u63a5\u53d7\u5c0f\u6a97\u78b1\u6cbb\u75972\u30014\u30016\u4e2a\u6708\u540e\u7684\u62df\u6746\u83cc\u5c5e\u4e30\u5ea6\uff08n=7\uff09\u3002(I) \u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u63a5\u53d7\u5c0f\u6a97\u78b1\u6cbb\u75972\u30014\u30016\u4e2a\u6708\u540e\u7684\u62df\u6746\u83cc\u5c5e\u4e30\u5ea6\uff08n=13\uff09\u3002(J) \u53d7\u8bd5\u8005\u62df\u6746\u83cc\u5c5e\u4e30\u5ea6\u4e0e\u5c3f\u9178\u6c34\u5e73\u7684\u76f8\u5173\u6027\u5206\u6790\u3002(K) \u975e\u9ad8\u5c3f\u9178\u8840\u75c7\u5fd7\u613f\u8005\u63a5\u53d7\u5c0f\u6a97\u78b1\u6cbb\u75972\u30014\u30016\u4e2a\u6708\u540e\u7684\u4e25\u683c\u68ad\u83cc1\u578b\u4e30\u5ea6\uff08n=12\uff09\u3002(L) \u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u63a5\u53d7\u5c0f\u6a97\u78b1\u6cbb\u75972\u30014\u30016\u4e2a\u6708\u540e\u7684\u4e25\u683c\u68ad\u83cc1\u578b\u4e30\u5ea6\uff08n=7\uff09\u3002(M) \u53d7\u8bd5\u8005\u4e25\u683c\u68ad\u83cc1\u578b\u4e30\u5ea6\u4e0e\u5c3f\u9178\u6c34\u5e73\u7684\u76f8\u5173\u6027\u5206\u6790\u3002<\/p>\n

\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f<\/figure>\n

\u56fe4 \u8106\u5f31\u62df\u6746\u83cc\uff08Bacteroides fragilis\uff09\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u7425\u73c0\u9178\u663e\u8457\u964d\u4f4e\u9ad8\u5c3f\u9178\u8840\u75c7\u52a8\u7269\u6a21\u578b\u7684\u8840\u6d46\u5c3f\u9178\u6c34\u5e73<\/p>\n

(A) \u8106\u5f31\u62df\u6746\u83cc\u5728\u679c\u7cd6\u8bf1\u5bfc\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u4e2d\u7814\u7a76\u7684\u5b9e\u9a8c\u5206\u7ec4\u53ca\u65b9\u6848\u3002(B) \u8106\u5f31\u62df\u6746\u83cc\u5904\u7406\u7684\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u52a8\u7269\u7684\u5c3f\u9178\u6c34\u5e73\uff08\u5bf9\u7167\u7ec4\uff1an=9\uff1b\u6a21\u578b\u7ec4\uff1an=9\uff1b\u8106\u5f31\u62df\u6746\u83cc\u7ec4\uff1an=8\uff1b\u8106\u5f31\u62df\u6746\u83cc+\u5c0f\u6a97\u78b1\u7ec4\uff1an=8\uff09\u3002(C) \u8106\u5f31\u62df\u6746\u83cc\u5904\u7406\u7684\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u52a8\u7269\u7caa\u4fbf\u4e2d\u7684\u7425\u73c0\u9178\u542b\u91cf\uff08n=5\uff09\u3002(D) \u8106\u5f31\u62df\u6746\u83cc\u5904\u7406\u7684\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u52a8\u7269\u7caa\u4fbf\u4e2d\u7684\u4e19\u9178\u542b\u91cf\uff08n=5\uff09\u3002(E) \u7425\u73c0\u9178\u542b\u91cf\u4e0e\u5c3f\u9178\u6c34\u5e73\u7684\u76f8\u5173\u6027\u5206\u6790\u3002(F) \u4e19\u9178\u542b\u91cf\u4e0e\u5c3f\u9178\u6c34\u5e73\u7684\u76f8\u5173\u6027\u5206\u6790\u3002(G) \u7425\u73c0\u9178\u94a0\u5728\u679c\u7cd6\u8bf1\u5bfc\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u4e2d\u7814\u7a76\u7684\u5b9e\u9a8c\u5206\u7ec4\u53ca\u65b9\u6848\u3002(H) \u679c\u7cd6\u8bf1\u5bfc\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u4e2d\u7425\u73c0\u9178\u94a0\u7ed9\u836f\u540e\u7684\u5c3f\u9178\u6c34\u5e73\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=8\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=7\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=8\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\u3002(I) \u679c\u7cd6\u8bf1\u5bfc\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u4e2d\u7425\u73c0\u9178\u94a0\u7ed9\u836f\u540e\u7684\u809d\u810f\u78f7\u9178\u76d0\u6c34\u5e73\uff08n=8\uff09\u3002(J) \u57fa\u4e8e\u808c\u82f7\u751f\u6210\u901f\u7387\u8bc4\u4f30\u7684\u817a\u82f7\u4e00\u78f7\u9178\u8131\u6c28\u91762\uff08AMPD2\uff09\u6d3b\u6027\uff08n=6\uff09\u3002(K-O) \u8840\u6d46\u4e2d\u817a\u82f7\u4e00\u78f7\u9178\uff08AMP\uff09\uff08n=8\uff09\uff08K\uff09\u3001\u808c\u82f7\u4e00\u78f7\u9178\uff08IMP\uff09\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=8\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=7\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=8\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\uff08L\uff09\u3001\u808c\u82f7\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=8\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=7\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=8\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\uff08M\uff09\u3001\u6b21\u9ec4\u560c\u5464\uff08n=8\uff09\uff08N\uff09\u548c\u9ec4\u560c\u5464\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=8\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=7\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=8\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\uff08O\uff09\u7684\u6c34\u5e73\u3002<\/p>\n

\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f<\/figure>\n

\u56fe5 \u5c0f\u6a97\u78b1\uff08BBR\uff09\u901a\u8fc7\u80a0\u9053\u7425\u73c0\u9178\u964d\u4f4e\u4f53\u5185\u809d\u810f\u817a\u82f7\u4e00\u78f7\u9178\u8131\u6c28\u91762\uff08AMPD2\uff09\u6d3b\u6027\u5e76\u63d0\u9ad8\u78f7\u9178\u76d0\u6c34\u5e73\uff0c\u4ece\u800c\u6291\u5236\u5c3f\u9178\u5408\u6210\u901a\u8def<\/p>\n

(A) \u8c37\u6c28\u9178\u94a0\u8bf1\u5bfc\u9ad8\u5c3f\u9178\u8840\u75c7\u6a21\u578b\u7684\u5b9e\u9a8c\u5206\u7ec4\u53ca\u65b9\u6848\u3002(B) \u8840\u6d46\u5c3f\u9178\u6c34\u5e73\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=9\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=12\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\u3002(C) \u5c3f\u9178\u5408\u6210\u901a\u8def\u793a\u610f\u56fe\u3002(D) \u8840\u6d46\u817a\u82f7\u4e00\u78f7\u9178\uff08AMP\uff09\u6c34\u5e73\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=9\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=12\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\u3002(E) \u8840\u6d46\u808c\u82f7\u4e00\u78f7\u9178\uff08IMP\uff09\u6c34\u5e73\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=9\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=12\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\u3002(F) \u8840\u6d46\u808c\u82f7\u6c34\u5e73\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=9\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=12\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\u3002(G) \u8840\u6d46\u6b21\u9ec4\u560c\u5464\u6c34\u5e73\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=9\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=12\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\u3002(H) \u8840\u6d46\u9ec4\u560c\u5464\u6c34\u5e73\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=9\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=12\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\u3002(I) \u809d\u810f\u5300\u6d46\u4e2d\u7684\u817a\u82f7\u4e00\u78f7\u9178\u8131\u6c28\u91762\uff08AMPD2\uff09\u6d3b\u6027\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=9\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=12\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\u3002(J) \u809d\u810f\u78f7\u9178\u76d0\u6c34\u5e73\uff08\u5bf9\u7167\u7ec4\uff1an=8\uff1b\u6a21\u578b\u7ec4\uff1an=9\uff1b\u5c0f\u6a97\u78b1200 mg\/kg\u7ec4\uff1an=9\uff1b\u7425\u73c0\u9178\u94a0\u7ec4\uff1an=12\uff1b\u9633\u6027\u5bf9\u7167\u7ec4\uff1an=8\uff09\u3002(K) 293T\u7ec6\u80de\u4e2d\u7684\u5c3f\u9178\u6c34\u5e73\uff08n=6\uff09\u3002(L) 293T\u7ec6\u80de\u4e2d\u7684\u7ec6\u80de\u5185\u78f7\u9178\u76d0\u6c34\u5e73\uff08n=6\uff09\u3002(M) 293T\u7ec6\u80de\u4e2d\u7684\u4e09\u78f7\u9178\u817a\u82f7\uff08ATP\uff09\u6c34\u5e73\uff08n=6\uff09\u3002(N) 293T\u7ec6\u80de\u4e2d\u7684\u817a\u82f7\u4e00\u78f7\u9178\uff08AMP\uff09\u6c34\u5e73\uff08n=6\uff09\u3002(O) 293T\u7ec6\u80de\u4e2d\u7684\u808c\u82f7\u4e00\u78f7\u9178\uff08IMP\uff09\u6c34\u5e73\uff08n=6\uff09\u3002(P) 293T\u7ec6\u80de\u4e2d\u7684\u808c\u82f7\u6c34\u5e73\uff08n=6\uff09\u3002(Q) 293T\u7ec6\u80de\u4e2d\u7684\u6b21\u9ec4\u560c\u5464\u6c34\u5e73\uff08n=6\uff09\u3002(R) 293T\u7ec6\u80de\u4e2d\u7684\u9ec4\u560c\u5464\u6c34\u5e73\uff08n=6\uff09\u3002(S) \u6dfb\u52a00.625\u62162.5 mmol\/L\u7425\u73c0\u9178\u7684293T\u7ec6\u80de\u5185\u78f7\u9178\u76d0\u6c34\u5e73\uff08n=6\uff09\u3002(T) \u6dfb\u52a00.625\u62162.5 mmol\/L\u7425\u73c0\u9178\u7684293T\u7ec6\u80de\u5185\u4e09\u78f7\u9178\u817a\u82f7\uff08ATP\uff09\u6c34\u5e73\uff08n=6\uff09\u3002(U) \u7425\u73c0\u9178\u901a\u8fc7\u63d0\u9ad8\u7ec6\u80de\u5185\u78f7\u9178\u76d0\u6c34\u5e73\u6291\u5236AMPD2\u7684\u673a\u5236\u793a\u610f\u56fe\u3002<\/p>\n

\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f\"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u848b\u5efa\u4e1c\u548c\u738b\u7430\u7b49\u56e2\u961f\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7\u91cd\u5851\u80a0\u9053\u83cc\u7fa4\u5347\u9ad8\u7425\u73c0\u9178\uff0c\u6291\u5236\u809d\u810f<\/figure>\n

\u56fe6 \u5c0f\u6a97\u78b1\uff08BBR\uff09\u5728\u9ad8\u5c3f\u9178\u8840\u75c7\u76f8\u5173\u6027\u80be\u75c5\u6a21\u578b\u4e2d\u8868\u73b0\u51fa\u80be\u810f\u4fdd\u62a4\u4f5c\u7528<\/p>\n

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