{"id":67395,"date":"2026-08-20T07:54:41","date_gmt":"2026-08-20T07:54:41","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=67395"},"modified":"2026-08-20T07:54:41","modified_gmt":"2026-08-20T07:54:41","slug":"%e8%9a%8c%e5%9f%a0%e5%8c%bb%e7%a7%91%e5%a4%a7%e5%ad%a6%e5%9b%a2%e9%98%9f%e5%9c%a8phytomedicine%e5%8f%91%e6%96%87%ef%bc%8c%e9%80%9a%e8%bf%87%e5%9b%9b%e9%87%8d%e9%aa%8c%e8%af%81%e8%af%81%e5%ae%9e","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=67395","title":{"rendered":"\u868c\u57e0\u533b\u79d1\u5927\u5b66\u56e2\u961f\u5728Phytomedicine\u53d1\u6587\uff0c\u901a\u8fc7\u56db\u91cd\u9a8c\u8bc1\u8bc1\u5b9e\uff1a\u5c0f\u6a97\u78b1\u53ef\u7ecfSTAT3\/PAD4\u901a\u8def\u8c03\u63a7\u81ea\u566c\uff0c\u4ee5\u74dc\u6c28\u9178\u5316\u4e3a\u5173\u952e\u9776\u70b9\u6539\u5584\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002"},"content":{"rendered":"<p class=\"wp-block-paragraph\" id=\"activity-name\"><a href=\"void(0);\">\u96c6\u601d\u6167\u8fdc\u533b\u5b66<\/a> <em>2026\u5e744\u67086\u65e5 <\/em><\/p>\n<p class=\"wp-block-paragraph\"><strong>\u524d\u8a00<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09\u662f\u4e00\u7c7b\u4ee5\u6162\u6027\u6ed1\u819c\u708e\u75c7\u3001\u5173\u8282\u8fdb\u884c\u6027\u7834\u574f\u4e3a\u7279\u5f81\u7684\u81ea\u8eab\u514d\u75ab\u75c5\uff0c\u4e34\u5e8a\u7f3a\u4e4f\u7cbe\u51c6\u9776\u5411\u7684\u5e72\u9884\u624b\u6bb5\u3002\u86cb\u767d\u74dc\u6c28\u9178\u5316\u662fRA\u7279\u5f81\u6027\u75c5\u7406\u8fdb\u7a0b\uff0c\u4e3b\u8981\u7531PAD4\u50ac\u5316\u4ecb\u5bfc\uff0c\u53ef\u8bf1\u53d1\u81ea\u8eab\u514d\u75ab\u5e94\u7b54\uff0c\u63a8\u52a8\u5173\u8282\u635f\u4f24\uff1b\u800c\u6210\u7ea4\u7ef4\u6837\u6ed1\u819c\u7ec6\u80de\uff08FLS\uff09\u5f02\u5e38\u6d3b\u5316\u4e0e\u81ea\u566c\u5931\u8861\uff0c\u662f\u4ecb\u5bfcPAD4\u9ad8\u8868\u8fbe\u3001\u74dc\u6c28\u9178\u5316\u52a0\u5267\u7684\u6838\u5fc3\u7ec6\u80de\u57fa\u7840\u3002\u5c0f\u6a97\u78b1\u662f\u7ecf\u5178\u4e2d\u836f\u6d3b\u6027\u6210\u5206\uff0c\u5177\u5907\u6297\u708e\u3001\u81ea\u566c\u8c03\u63a7\u7b49\u6d3b\u6027\uff0c\u4f46\u5176\u5bf9RA-FLS\u86cb\u767d\u74dc\u6c28\u9178\u5316\u7684\u8c03\u63a7\u4f5c\u7528\u53ca\u5206\u5b50\u901a\u8def\u5c1a\u4e0d\u660e\u786e\u3002\u672c\u7814\u7a76\u65e8\u5728\u89e3\u6790\u5176\u5e72\u9884\u673a\u5236\uff0c\u4e3aRA\u9776\u5411\u6cbb\u7597\u53ca\u4e2d\u836f\u73b0\u4ee3\u5316\u7814\u7a76\u63d0\u4f9b\u5b9e\u9a8c\u4f9d\u636e\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<ol class=\"wp-block-list\">\n<li>\u4ee5TNF-\u03b1\u8bf1\u5bfc\u6784\u5efaFLS\u6d3b\u5316\u6a21\u578b\uff0c\u660e\u786e\u5c0f\u6a97\u78b1\u5bf9FLS\u6d3b\u5316\u53ca\u86cb\u767d\u74dc\u6c28\u9178\u5316\u7684\u57fa\u7840\u8c03\u63a7\u4f5c\u7528\uff1b<\/li>\n<li>\u63a2\u7a76\u81ea\u566c\u5728\u8be5\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\uff0c\u901a\u8fc7\u81ea\u566c\u6fc0\u6d3b\u5242\u3001\u6291\u5236\u5242\u7684\u56de\u590d\u5b9e\u9a8c\uff0c\u9a8c\u8bc1\u81ea\u566c\u4e0e\u74dc\u6c28\u9178\u5316\u7684\u56e0\u679c\u5173\u7cfb\uff1b<\/li>\n<li>\u6df1\u5165\u89e3\u6790\u4e0b\u6e38\u5206\u5b50\u901a\u8def\uff0c\u805a\u7126STAT3\/PAD4\u8f74\uff0c\u660e\u786e\u5c0f\u6a97\u78b1\u8c03\u63a7\u81ea\u566c\u540e\u5bf9\u8be5\u901a\u8def\u7684\u5f71\u54cd\u53ca\u5206\u5b50\u673a\u5236\uff1b<\/li>\n<li>\u901a\u8fc7RA\u52a8\u7269\u6a21\u578b\uff0c\u5728\u4f53\u5185\u9a8c\u8bc1\u5c0f\u6a97\u78b1\u7684\u5e72\u9884\u6548\u5e94\u53ca\u6838\u5fc3\u901a\u8def\uff0c\u5f62\u6210\u201c\u73b0\u8c61-\u673a\u5236-\u4f53\u5185\u9a8c\u8bc1\u201d\u7684\u5b8c\u6574\u7814\u7a76\u903b\u8f91\uff0c\u7cfb\u7edf\u63ed\u793a\u5c0f\u6a97\u78b1\u6539\u5584RA\u7684\u5206\u5b50\u673a\u5236\u3002<\/li>\n<\/ol>\n<p class=\"wp-block-paragraph\"><img decoding=\"async\" title=\"\u868c\u57e0\u533b\u79d1\u5927\u5b66\u56e2\u961f\u5728Phytomedicine\u53d1\u6587\uff0c\u901a\u8fc7\u56db\u91cd\u9a8c\u8bc1\u8bc1\u5b9e\uff1a\u5c0f\u6a97\u78b1\u53ef\u7ecfSTAT3\/PAD4\u901a\u8def\u8c03\u63a7\u81ea\u566c\uff0c\u4ee5\u74dc\u6c28\u9178\u5316\u4e3a\u5173\u952e\u9776\u70b9\u6539\u5584\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002 - \u7b2c1\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u868c\u57e0\u533b\u79d1\u5927\u5b66\u56e2\u961f\u5728Phytomedicine\u53d1\u6587\uff0c\u901a\u8fc7\u56db\u91cd\u9a8c\u8bc1\u8bc1\u5b9e\uff1a\u5c0f\u6a97\u78b1\u53ef\u7ecfSTAT3\/PAD4\u901a\u8def\u8c03\u63a7\u81ea\u566c\uff0c\u4ee5\u74dc\u6c28\u9178\u5316\u4e3a\u5173\u952e\u9776\u70b9\u6539\u5584\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002 - \u7b2c1\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" data-perfmatters-preload src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/Picdy27iaJQgTeicjJMcm60icsHiaasLZzGfgIWO16TjdndOsFa9YtzkqbZgn2keqgLrPRhru6YoZnaTqRjbGw1Yg8ej4wepaWFNDWCPpB883zR0\/640?wx_fmt=jpeg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1&amp;watermark=1#imgIndex=1\" class=\"\"><\/p>\n<p class=\"wp-block-paragraph\">\u82f1\u6587\u6807\u9898\uff1aBerberine inhibits protein citrullination of fibroblast-like synoviocytes by suppressing autophagy via STAT3\/PAD4 pathway, <a href=\"https:\/\/doi.org\/10.1016\/j.phymed.2025.157706\">Https:\/\/doi.org\/10.1016\/j.phymed.2025.157706<\/a><\/p>\n<p class=\"wp-block-paragraph\">\u4e2d\u6587\u6807\u9898\uff1a\u5c0f\u6a97\u78b1\u901a\u8fc7STAT3\/PAD4\u901a\u8def\u6291\u5236\u81ea\u566c\uff0c\u4ece\u800c\u6291\u5236\u6210\u7ea4\u7ef4\u6837\u6ed1\u819c\u7ec6\u80de\u7684\u86cb\u767d\u8d28\u74dc\u6c28\u9178\u5316<\/p>\n<p class=\"wp-block-paragraph\">\u5f71\u54cd\u56e0\u5b50\uff1a8.3<\/p>\n<p class=\"wp-block-paragraph\">\u4f5c\u8005\u5355\u4f4d\uff1a\u868c\u57e0\u533b\u79d1\u5927\u5b66\u836f\u5b66\u9662<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u7ed3\u679c<\/strong><\/p>\n<p class=\"wp-block-paragraph\"><strong>1. 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STAT3\/PAD4\u8f74\u662f\u5c0f\u6a97\u78b1\u8c03\u63a7\u74dc\u6c28\u9178\u5316\u7684\u6838\u5fc3\u901a\u8def<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u751f\u4fe1\u5206\u6790\u53caCETSA\u3001SIP\u548cSPR\u6d4b\u5b9aSTAT3\u662f\u8fde\u63a5\u81ea\u566c\u4e0ePAD4\u4ecb\u5bfc\u74dc\u6c28\u9178\u5316\u7684\u5173\u952e\u4fe1\u53f7\u5206\u5b50\u3002TNF-\u03b1\u8bf1\u5bfc\u7684\u6d3b\u5316FLS\u4e2d\uff0cSTAT3\u78f7\u9178\u5316\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff0c\u6838\u8f6c\u4f4d\u589e\u5f3a\uff0c\u4e14\u67d3\u8272\u8d28\u514d\u75ab\u6c89\u6dc0\u5b9e\u9a8c\uff08ChIP\uff09\u8bc1\u5b9e\uff0c\u6d3b\u5316\u7684STAT3\u53ef\u76f4\u63a5\u7ed3\u5408PAD4\u542f\u52a8\u5b50\u533a\u57df\uff0c\u6b63\u5411\u8c03\u63a7PAD4\u8f6c\u5f55\u8868\u8fbe\u3002\u5c0f\u6a97\u78b1\u901a\u8fc7\u6291\u5236FLS\u81ea\u566c\uff0c\u8fdb\u4e00\u6b65\u963b\u65adSTAT3\u78f7\u9178\u5316\u6d3b\u5316\u4e0e\u6838\u8f6c\u4f4d\uff0c\u4e0b\u8c03PAD4\u8868\u8fbe\uff0c\u6700\u7ec8\u51cf\u5c11\u86cb\u767d\u74dc\u6c28\u9178\u5316\uff1b\u800c\u8fc7\u8868\u8fbeSTAT3\u53ef\u5b8c\u5168\u9006\u8f6c\u5c0f\u6a97\u78b1\u7684\u5e72\u9884\u6548\u5e94\uff0c\u660e\u786e<strong>STAT3\/PAD4\u8f74\u662f\u5c0f\u6a97\u78b1\u53d1\u6325\u4f5c\u7528\u7684\u6838\u5fc3\u4e0b\u6e38\u901a\u8def<\/strong>\u3002<img decoding=\"async\" title=\"\u868c\u57e0\u533b\u79d1\u5927\u5b66\u56e2\u961f\u5728Phytomedicine\u53d1\u6587\uff0c\u901a\u8fc7\u56db\u91cd\u9a8c\u8bc1\u8bc1\u5b9e\uff1a\u5c0f\u6a97\u78b1\u53ef\u7ecfSTAT3\/PAD4\u901a\u8def\u8c03\u63a7\u81ea\u566c\uff0c\u4ee5\u74dc\u6c28\u9178\u5316\u4e3a\u5173\u952e\u9776\u70b9\u6539\u5584\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002 - 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\u7b2c9\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u868c\u57e0\u533b\u79d1\u5927\u5b66\u56e2\u961f\u5728Phytomedicine\u53d1\u6587\uff0c\u901a\u8fc7\u56db\u91cd\u9a8c\u8bc1\u8bc1\u5b9e\uff1a\u5c0f\u6a97\u78b1\u53ef\u7ecfSTAT3\/PAD4\u901a\u8def\u8c03\u63a7\u81ea\u566c\uff0c\u4ee5\u74dc\u6c28\u9178\u5316\u4e3a\u5173\u952e\u9776\u70b9\u6539\u5584\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002 - \u7b2c9\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/Picdy27iaJQgRwQiayjsAgDXmngXoV4PuuGPsjXH3Z51L9G5vdhGSO8BXS9pBPsIRCjhfpa3OYMhLSGma6cbWsvWVibydv2UeXlCfLFu8HE5jos\/640?wx_fmt=jpeg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1&amp;watermark=1#imgIndex=6\" class=\"\"><\/p>\n<p class=\"wp-block-paragraph\"><strong>3. \u4f53\u5185\u5916\u5b9e\u9a8c\u9a8c\u8bc1\u5c0f\u6a97\u78b1\u7684\u6297RA\u6548\u5e94<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u6784\u5efaRA\u52a8\u7269\u6a21\u578b\uff0c\u7ecf\u5c0f\u6a97\u78b1\u5e72\u9884\u540e\uff0c\u52a8\u7269\u5173\u8282\u80bf\u80c0\u7a0b\u5ea6\u3001\u6ed1\u819c\u589e\u751f\u3001\u708e\u6027\u7ec6\u80de\u6d78\u6da6\u53ca\u8f6f\u9aa8\u7834\u574f\u60c5\u51b5\u5747\u663e\u8457\u6539\u5584\uff0c\u5173\u8282\u7ec4\u7ec7\u4e2d\u74dc\u6c28\u9178\u5316\u86cb\u767d\u6c89\u79ef\u3001p-STAT3\u53caPAD4\u8868\u8fbe\u6c34\u5e73\u660e\u663e\u964d\u4f4e\uff0c\u81ea\u566c\u6c34\u5e73\u88ab\u6709\u6548\u6291\u5236\uff0c\u4e0e\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\u7ed3\u679c\u5b8c\u5168\u4e00\u81f4\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u5c0f\u6a97\u78b1\u53ef\u901a\u8fc7\u8c03\u63a7\u81ea\u566c-STAT3\/PAD4\u8f74\u53d1\u6325\u6297RA\u4f5c\u7528\u3002<img decoding=\"async\" title=\"\u868c\u57e0\u533b\u79d1\u5927\u5b66\u56e2\u961f\u5728Phytomedicine\u53d1\u6587\uff0c\u901a\u8fc7\u56db\u91cd\u9a8c\u8bc1\u8bc1\u5b9e\uff1a\u5c0f\u6a97\u78b1\u53ef\u7ecfSTAT3\/PAD4\u901a\u8def\u8c03\u63a7\u81ea\u566c\uff0c\u4ee5\u74dc\u6c28\u9178\u5316\u4e3a\u5173\u952e\u9776\u70b9\u6539\u5584\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002 - \u7b2c10\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u868c\u57e0\u533b\u79d1\u5927\u5b66\u56e2\u961f\u5728Phytomedicine\u53d1\u6587\uff0c\u901a\u8fc7\u56db\u91cd\u9a8c\u8bc1\u8bc1\u5b9e\uff1a\u5c0f\u6a97\u78b1\u53ef\u7ecfSTAT3\/PAD4\u901a\u8def\u8c03\u63a7\u81ea\u566c\uff0c\u4ee5\u74dc\u6c28\u9178\u5316\u4e3a\u5173\u952e\u9776\u70b9\u6539\u5584\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002 - \u7b2c10\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/Picdy27iaJQgRdD9xD7AgEibiaTU5tjAHOE9U18mgaFyWPnbpiczWHRiaHiaRWq0Z5UR8PiczVOJHQ5cYuAzbXtibuCctLuGj9k840pkz79SNYd0avEw\/640?wx_fmt=jpeg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1&amp;watermark=1#imgIndex=7\" \/><img decoding=\"async\" title=\"\u868c\u57e0\u533b\u79d1\u5927\u5b66\u56e2\u961f\u5728Phytomedicine\u53d1\u6587\uff0c\u901a\u8fc7\u56db\u91cd\u9a8c\u8bc1\u8bc1\u5b9e\uff1a\u5c0f\u6a97\u78b1\u53ef\u7ecfSTAT3\/PAD4\u901a\u8def\u8c03\u63a7\u81ea\u566c\uff0c\u4ee5\u74dc\u6c28\u9178\u5316\u4e3a\u5173\u952e\u9776\u70b9\u6539\u5584\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002 - 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