{"id":67177,"date":"2026-08-20T07:32:13","date_gmt":"2026-08-20T07:32:13","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=67177"},"modified":"2026-08-20T07:32:13","modified_gmt":"2026-08-20T07:32:13","slug":"%e4%bc%8a%e7%bb%b4%e8%8f%8c%e7%b4%a0%e4%b8%8e%e8%8a%ac%e8%8b%af%e8%be%be%e5%94%91","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=67177","title":{"rendered":"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u4f0a\u7ef4\u83cc\u7d20\u548c\u82ac\u82ef\u8fbe\u5511\uff0c\u5b83\u4eec\u6700\u521d\u88ab\u53d1\u73b0\u5e76\u7528\u4f5c\u80c3\u80a0\u9053\u6297\u5bc4\u751f\u866b\u836f\u7269\u3002\u5b83\u4eec\u6740\u6b7b\u5bc4\u751f\u866b\uff0c\u4e3b\u8981\u9488\u5bf9\u80a0\u9053\u5185\u7684\u5bc4\u751f\u866b\u3002\u5b83\u4eec\u57fa\u672c\u4e0a\u662f\u52a8\u7269\u9a71\u866b\u836f\u3002\u4f0a\u7ef4\u83cc\u7d20\u7528\u4e8e\u8bb8\u591a\u52a8\u7269\uff0c\u4f46\u6700\u8457\u540d\u7684\u662f\u7528\u4e8e\u9a6c\uff0c\u800c\u82ac\u82ef\u8fbe\u5511\u7528\u4e8e\u72d7\u3002\u4f46\u4f0a\u7ef4\u83cc\u7d20\u4e5f\u5df2\u4f5c\u4e3a\u4eba\u7c7b\u7684\u6297\u5bc4\u751f\u866b\u836f\u4f7f\u7528\u4e86\u6570\u5341\u5e74\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u56e0\u6b64\uff0c\u6709\u5927\u91cf\u76f8\u5173\u6570\u636e\u3002\u4f46\u8fd1\u5e74\u6765\uff0c\u90e8\u5206\u5f97\u76ca\u4e8eCOVID\u5927\u6d41\u884c\uff0c\u7814\u7a76\u663e\u793a\u5b83\u4eec\u4e5f\u80fd\u6740\u6b7b\u764c\u75c7\uff0c\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u3001\u5728\u5c0f\u9f20\u4e2d\uff0c\u751a\u81f3\u5728\u4eba\u7c7b\u4e2d\u3002\u800c\u4e14\u6240\u6709\u8fd9\u4e9b\u90fd\u6ca1\u6709\u4e25\u91cd\u526f\u4f5c\u7528\u3002<\/p>\n<p class=\"wp-block-paragraph\">1987\u5e74\u83b7\u6279\u7528\u4e8e\u4eba\u7c7b\uff0c[\u4f0a\u7ef4\u83cc\u7d20]\u5728\u5e94\u5bf9\u4e16\u754c\u4e0a\u4e00\u4e9b\u6700\u5177\u5371\u5bb3\u7684\u70ed\u5e26\u75be\u75c5\u65b9\u9762\u53d1\u6325\u4e86\u5173\u952e\u4f5c\u7528\uff0c\u4f8b\u5982\u76d8\u5c3e\u4e1d\u866b\u75c5\u3001\u6dcb\u5df4\u4e1d\u866b\u75c5\uff08\u4e5f\u79f0\u4e3a\u8c61\u76ae\u75c5\uff09\u3001\u7c7b\u5706\u7ebf\u866b\u75c5\u548c\u75a5\u75ae\u3002\u5b83\u8fd8\u80fd\u6709\u6548\u5bf9\u6297\u52a8\u7269\u7684\u5bc4\u751f\u866b\u611f\u67d3\uff0c\u8fd9\u5bf9\u755c\u7267\u4e1a\u53ef\u80fd\u9020\u6210\u7ecf\u6d4e\u6bc1\u706d\u6027\u6253\u51fb\u2026\u2026\u4f0a\u7ef4\u83cc\u7d20\u662f\u5df2\u77e5\u6700\u5b89\u5168\u7684\u836f\u7269\u4e4b\u4e00\u3002\u5b83\u4f4d\u5217\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u7684\u57fa\u672c\u836f\u7269\u6e05\u5355\uff0c\u5df2\u5728\u5168\u7403\u5206\u53d1\u8d85\u8fc740\u4ebf\u6b21\uff0c\u5e76\u56e0\u5176\u5728\u5168\u7403\u8303\u56f4\u5185\u6839\u9664\u8bb8\u591a\u5730\u533a\u5730\u65b9\u6027\u5bc4\u751f\u866b\u611f\u67d3\u7684\u5386\u53f2\u6027\u5f71\u54cd\u800c\u83b7\u5f97\u8bfa\u8d1d\u5c14\u5956\u3002\u201d<\/p>\n<p class=\"wp-block-paragraph\">WHO\u75a5\u75ae\u6307\u5357\uff1a\u201c\u5927\u591a\u6570\u526f\u4f5c\u7528\u90fd\u662f\u8f7b\u5fae\u4e14\u6682\u65f6\u7684\u201d<\/p>\n<p class=\"wp-block-paragraph\">Jacques Descotes\u6559\u6388\uff0c\u6bd2\u7406\u5b66\u5bb6\u53ca\u4f0a\u7ef4\u83cc\u7d20\u5b89\u5168\u6027\u4e13\u5bb6\uff1a\u201c\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u65e0\u7591\u4e14\u6781\u4e3a\u7f55\u89c1\u201d<br \/>LiverTox\u6570\u636e\u5e93\uff1a\u4e0d\u88ab\u8ba4\u4e3a\u5bf9\u809d\u810f\u6709\u6bd2\u6027<br \/>Nephrotox\u6570\u636e\u5e93\uff1a\u4e0d\u88ab\u8ba4\u4e3a\u5bf9\u80be\u810f\u6709\u6bd2\u6027<br \/>PneumoTox\uff1a\u4e0d\u88ab\u8ba4\u4e3a\u5bf9\u80ba\u90e8\u6709\u6bd2\u6027<\/p>\n<p class=\"wp-block-paragraph\">\u4f0a\u7ef4\u83cc\u7d20\u4f5c\u4e3a\u4eba\u7c7b\u6297\u5bc4\u751f\u866b\u836f\u7684\u6807\u51c6\u5242\u91cf\u4e3a\u6bcf\u59290.2mg\/kg\u3002\u5bf9\u4e8e\u4e00\u4e2a190\u78c5\u7684\u7537\u6027\u6765\u8bf4\uff0c\u8fd9\u662f17.2\u6beb\u514b\u3002\u4f46\u5373\u4f7f\u5242\u91cf\u9ad8\u5f97\u591a\uff0c\u9ad8\u8fbe10\u500d\uff0c\u5b83\u4e5f\u6781\u5176\u5b89\u5168\uff1a<\/p>\n<p 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class=\"wp-block-paragraph\">\u5c3d\u53ef\u80fd\u7b80\u8981\u603b\u7ed3\u7814\u7a76\u53d1\u73b0\uff0c\u4f0a\u7ef4\u83cc\u7d20\u81f3\u5c11\u670915\u79cd\u6297\u764c\u4f5c\u7528\u673a\u5236\u3002\u6709\u8bc1\u636e\u8868\u660e\u4f0a\u7ef4\u83cc\u7d20\u53ef\u4ee5\u6cbb\u7597\u51e0\u4e4e\u6240\u6709\u7c7b\u578b\u7684\u764c\u75c7\uff0c\u6700\u91cd\u8981\u7684\u662f\u5305\u62ec\u7ed3\u80a0\u764c\uff0c\u751a\u81f34\u671f\u7ed3\u80a0\u764c\u3002\u4f0a\u7ef4\u83cc\u7d20\u5df2\u88ab\u8bc1\u660e\u80fd\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u65e2\u5728\u4f53\u5916\uff08\u5728\u57f9\u517b\u76bf\u4e2d\uff09\u4e5f\u5728\u4f53\u5185\uff08\u5728\u6d3b\u4f53\u751f\u7269\u4e2d\uff0c\u4e3b\u8981\u4e3a\u5c0f\u9f20\uff09<\/p>\n<p class=\"wp-block-paragraph\">\u4f53\u5916\u7814\u7a76\uff1a<br \/>\u4e73\u817a\u764c\u3001\u5375\u5de2\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u7ed3\u80a0\u764c\u3001\u80f0\u817a\u764c\u3001\u5934\u9888\u764c\u3001\u9ed1\u8272\u7d20\u7624 \u2013 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\u80bf\u7624\u4f53\u79ef\u51cf\u5c11\u9ad8\u8fbe50%\uff08\u5242\u91cf0.24mg\/kg\uff09\uff0c\u4f46\u5728\u76f8\u5f53\u4e8e\u4eba\u7c7b0.8mg\/kg\u7684\u5242\u91cf\u4e0b\uff0c\u80bf\u7624\u4e0d\u53ef\u68c0\u6d4b\uff01<br \/>\u7ed3\u80a0\u764c \u2013 \u80bf\u7624\u4f53\u79ef\u51cf\u5c11\u9ad8\u8fbe85%<br \/>\u6240\u7528\u4e2d\u4f4d\u5242\u91cf\u76f8\u5f53\u4e8e\u4eba\u7c7b0.4 mg\/kg\uff0c\u4ece10\u5929\u81f342\u5929\uff08\u53e3\u670d\u3001\u8179\u8154\u6ce8\u5c04\u6216\u7624\u5185\u6ce8\u5c04\uff09<br \/>\u4f0a\u7ef4\u83cc\u7d20\u7684\u4f53\u5916\u548c\u4f53\u5185\u6297\u80bf\u7624\u6d3b\u6027\u662f\u5728\u57fa\u4e8e\u5065\u5eb7\u548c\u5bc4\u751f\u866b\u611f\u67d3\u60a3\u8005\u7684\u4eba\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u4e2d\u4e34\u5e8a\u53ef\u8fbe\u5230\u7684\u6d53\u5ea6\u4e0b\u5b9e\u73b0\u7684<\/p>\n<p class=\"wp-block-paragraph\">\u5173\u4e8e\u82ac\u82ef\u8fbe\u5511\u5728\u4eba\u7c7b\u4e2d\u7684\u4f7f\u7528\u7814\u7a76\u4e0d\u591a\uff0c\u867d\u7136\u6ca1\u6709\u5173\u4e8e\u5176\u526f\u4f5c\u7528\u7684\u786c\u6027\u6570\u636e\u2026\u2026<br \/>\u2026\u2026\u5927\u591a\u6570\u4eba\u6ca1\u6709\u526f\u4f5c\u7528\u3002\u5c11\u6570\u7ecf\u5386\u526f\u4f5c\u7528\u7684\u5c0f\u7fa4\u4f53\u4e3b\u8981\u62b1\u6028\u662f\uff1a<br \/>* \u8f7b\u5ea6\u8179\u6cfb<br \/>* \u8f7b\u5ea6\u80c3\u90e8\u4e0d\u9002<br \/>* \u809d\u9176\u5347\u9ad8<\/p>\n<p class=\"wp-block-paragraph\">\n<h1 class=\"wp-block-heading\">\u82ac\u82ef\u8fbe\u5511\u6297\u80bf\u7624\u7814\u7a76\u5927\u6c47\u603b<\/h1>\n<p class=\"wp-block-paragraph\">Dr. Tang Dr. Tang <a href=\"void(0);\">\u8425\u536b\u8363\u517b<\/a> <em>2024\u5e749\u670813\u65e5 <\/em><\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n<p class=\"wp-block-paragraph\"><strong>\u82ac\u82ef\u8fbe\u5511\uff08Fenbendazole\uff09<\/strong>\u7528\u4f5c\u72ac\u7c7b\u548c\u5176\u4ed6\u52a8\u7269\u7684\u6297\u5bc4\u751f\u866b\u6cbb\u7597\u836f\u7269\u3002\u82ac\u82ef\u8fbe\u5511\u4e0e\u5bc4\u751f\u866b\u7684\u03b2-\u5fae\u7ba1\u86cb\u767d\u7ed3\u5408\uff0c\u5f15\u8d77\u5fae\u7ba1\u7684\u4e0d\u7a33\u5b9a\uff0c\u4ece\u800c\u7834\u574f\u5bc4\u751f\u866b\u7684\u7ec6\u80de\u529f\u80fd\uff0c\u5982\u8461\u8404\u7cd6\u6444\u53d6\uff0c\u8fdb\u800c\u5f71\u54cd\u5176\u80fd\u91cf\u4ee3\u8c22\u3002\u7531\u4e8e\u53e3\u670d\u5438\u6536\u8f83\u5dee\uff0c\u82ac\u82ef\u8fbe\u5511\u7279\u522b\u9002\u7528\u4e8e\u9776\u5411\u80a0\u9053\u5bc4\u751f\u866b\u3002<img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c1\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c1\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" data-perfmatters-preload src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND4sNtVFwicGictUJ1jDYaLToHWnicVWEWFFvQcfVRoVaia0erwOrguWpt5FQ\/640?wx_fmt=jpeg&amp;from=appmsg&amp;wxfrom=13&amp;tp=wxpic#imgIndex=0\"><\/p>\n<p class=\"wp-block-paragraph\">2016\u5e748\u6708\uff0c\u82ac\u82ef\u8fbe\u5511\u56e0Joe Tippens\u7684\u6210\u529f\u5eb7\u590d\u6848\u4f8b\u800c\u5f15\u8d77\u4e86\u5168\u7403\u5173\u6ce8\u3002Joe Tippens\u88ab\u8bca\u65ad\u4e3a\u5c0f\u7ec6\u80de\u80ba\u764c\u3002\u5f53\u65f6\uff0c\u4ed6\u6b63\u53c2\u4e0e\u4e00\u9879\u65b0\u578b\u6297\u764c\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u540c\u65f6\uff0c\u5728\u4e00\u4f4d\u517d\u533b\u7684\u6307\u5bfc\u4e0b\uff0cTippens\u5f00\u59cb\u81ea\u884c\u53e3\u670d222\u6beb\u514b\u82ac\u82ef\u8fbe\u5511\uff0c\u5e76\u8f85\u4ee5\u7ef4\u751f\u7d20E\u8865\u5145\u5242\u3001CBD\uff08\u5927\u9ebb\u4e8c\u915a\uff09\u6cb9\u548c\u59dc\u9ec4\u7d20\u3002\u4e09\u4e2a\u6708\u540e\uff0cPET\u626b\u63cf\u663e\u793a\u4ed6\u7684\u4f53\u5185\u6ca1\u6709\u53ef\u68c0\u6d4b\u5230\u7684\u764c\u7ec6\u80de\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u57281100\u540d\u4e34\u5e8a\u8bd5\u9a8c\u53c2\u4e0e\u8005\u4e2d\uff0cTippens\u662f\u552f\u4e00\u4e00\u4f4d\u764c\u75c7\u5b8c\u5168\u6cbb\u6108\u7684\u60a3\u8005\u3002\u5c3d\u7ba1Joe Tippens\u7684\u6848\u4f8b\u5177\u6709\u5438\u5f15\u529b\uff0c\u4f46\u5b83\u4ec5\u662f\u4e00\u4e2a\u8f76\u4e8b\u6027\u62a5\u544a\uff0c\u8fd9\u7a81\u663e\u4e86\u5f00\u5c55\u4e25\u683c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6765\u9a8c\u8bc1\u82ac\u82ef\u8fbe\u5511\u4f5c\u4e3a\u6297\u764c\u7597\u6cd5\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u5fc5\u8981\u6027\u3002<\/p>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c2\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c2\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND4GumU9pIuBSOJ85qicZMypS71Aqk6ONwyc5AdfZXPop1XsxaFEEOVjpg\/640?wx_fmt=png&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=10005&amp;wx_lazy=1#imgIndex=1\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c3\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c3\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND4GumU9pIuBSOJ85qicZMypS71Aqk6ONwyc5AdfZXPop1XsxaFEEOVjpg\/640?wx_fmt=png&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=10005&amp;wx_lazy=1#imgIndex=1\" \/><\/figure>\n<p class=\"wp-block-paragraph\">\u82ac\u82ef\u8fbe\u5511\u7684\u6297\u764c\u6d3b\u6027\u5df2\u5728\u591a\u79cd\u7ec6\u80de\u7cfb\u8fdb\u884c\u4e86\u4f53\u5916\u7814\u7a76\uff0c\u663e\u793a\u5bf9\u591a\u79cd\u764c\u7ec6\u80de\u5177\u6709\u6291\u5236\u6548\u679c\u3002\u5bf95-FU\u3001\u7d2b\u6749\u9187\u548c\u591a\u897f\u4ed6\u8d5b\u8010\u836f\u7684\u764c\u7ec6\u80de\u4e5f\u8868\u73b0\u51fa\u6291\u5236\u4f5c\u7528\u3002\u5c3d\u7ba1\u82ac\u82ef\u8fbe\u5511\u663e\u793a\u51fa\u4ee4\u4eba\u632f\u594b\u7684\u6297\u764c\u6548\u679c\uff0c\u4f46\u5b83\u7684\u6c34\u6eb6\u6027\u975e\u5e38\u5dee\uff0c\u7ed9\u836f\u540e\u8840\u836f\u6d53\u5ea6\u5f88\u4f4e\u3002\u56e0\u6b64\uff0c\u89e3\u51b3\u5176\u836f\u4ee3\u52a8\u529b\u5b66\u65b9\u9762\u7684\u9650\u5236\u5bf9\u4e8e\u5c06\u82ac\u82ef\u8fbe\u5511\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u82ac\u82ef\u8fbe\u5511\u7684\u6297\u764c\u673a\u5236\u4e0e\u9776\u70b9<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u82ac\u82ef\u8fbe\u5511\u7684\u6297\u764c\u673a\u5236\u5305\u62ec\u6fc0\u6d3bp53\uff0c\u6291\u5236\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767dGLUT1\u548c\u5df1\u7cd6\u6fc0\u9176\uff0c\u51cf\u5c11\u764c\u7ec6\u80de\u7684\u8461\u8404\u7cd6\u6444\u53d6\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u589e\u5f3a\u7684\u7cd6\u9175\u89e3<\/strong>\u662f\u80bf\u7624\u8fdb\u5c55\u7684\u4e00\u4e2a\u5173\u952e\u4fe1\u53f7\u3002\u4e0e\u6b63\u5e38\u7ec6\u80de\u4e0d\u540c\uff0c\u764c\u7ec6\u80de\u5373\u4f7f\u5728\u6709\u6c27\u6761\u4ef6\u4e0b\u4e5f\u901a\u8fc7\u7cd6\u9175\u89e3\u5c06\u8461\u8404\u7cd6\u4ee3\u8c22\u4e3a\u4e73\u9178\u4f9b\u80fd\u3002\u5c3d\u7ba1\u7cd6\u9175\u89e3\u4e0d\u662f\u4e00\u79cd\u9ad8\u6548\u7684\u4f9b\u80fd\u65b9\u5f0f\uff0c\u4ea7\u751f\u7684ATP\u6bd4\u6c27\u5316\u78f7\u9178\u5316\u5c11\uff0c\u4f46\u764c\u7ec6\u80de\u7279\u522b\u4f9d\u8d56\u8fd9\u79cd\u7cd6\u4ee3\u8c22\u65b9\u5f0f\u3002\u7cd6\u9175\u89e3\u4ea7\u751f\u7684\u4e73\u9178\u4f7f\u80bf\u7624\u5fae\u73af\u5883\u9178\u5316\uff0c\u53ef\u5bfc\u81f4\u836f\u7269\u8010\u53d7\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767dGLUT1\u572899%\u7684\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u548c50%\u7684\u817a\u764c\u60a3\u8005\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u56e0\u6b64\u88ab\u8ba4\u4e3a\u662f\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u4e00\u4e2a\u6709\u524d\u666f\u7684\u9776\u70b9\u3002\u82ac\u82ef\u8fbe\u5511\u901a\u8fc7\u6fc0\u6d3bp53\u6291\u5236GLUT1\u548c\u5df1\u7cd6\u6fc0\u9176II\uff08HKII\uff09\u7684\u8868\u8fbe\uff0c\u963b\u6b62\u764c\u7ec6\u80de\u5229\u7528\u8461\u8404\u7cd6\u3002\u56e0\u6b64\uff0c\u82ac\u82ef\u8fbe\u5511\u53ef\u4ee5\u5bfc\u81f4\u764c\u7ec6\u80de\u201c\u9965\u997f\u201d\uff0c\u7834\u574f\u764c\u7ec6\u80de\u80fd\u91cf\u4ee3\u8c22\uff0c\u4ece\u800c\u964d\u4f4e\u4e73\u9178\u6c34\u5e73\uff0c\u9006\u8f6c\u836f\u7269\u8010\u53d7\u3002<\/p>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c4\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c4\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND4mB0ay6scOAjqHZdDMA9oXOia7HiaIjKgDE7CTib5TwjlXLPmiciaKS7vcEg\/640?wx_fmt=png&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=10005&amp;wx_lazy=1#imgIndex=2\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c5\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c5\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND4mB0ay6scOAjqHZdDMA9oXOia7HiaIjKgDE7CTib5TwjlXLPmiciaKS7vcEg\/640?wx_fmt=png&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=10005&amp;wx_lazy=1#imgIndex=2\" \/><\/figure>\n<p class=\"wp-block-paragraph\">\u9664\u4e86\u6291\u5236\u7cd6\u9175\u89e3\u5916\uff0c\u82ac\u82ef\u8fbe\u5511\u8fd8\u80fd\u8bf1\u5bfc\u764c\u7ec6\u80de\u51cb\u4ea1\u3002\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7ec6\u80de\u4e2d\uff0c\u82ac\u82ef\u8fbe\u5511\u901a\u8fc7\u7ebf\u7c92\u4f53\u635f\u4f24\u548ccaspase 3-PARP\u901a\u8def\u89e6\u53d1\u51cb\u4ea1\u3002\u5728\u91ce\u751f\u578bCRC\u4e2d\uff0c\u82ac\u82ef\u8fbe\u5511\u901a\u8fc7\u589e\u52a0p53\u8868\u8fbe\u6fc0\u6d3bp53\u4ecb\u5bfc\u7684\u51cb\u4ea1\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u5fae\u7ba1\u5728\u6709\u4e1d\u5206\u88c2\uff0c\u7ec6\u80de\u7ed3\u6784\u7ef4\u6301\u53ca\u5176\u4ed6\u7ec6\u80de\u4e8b\u4ef6\u4e2d\u6709\u91cd\u8981\u4f5c\u7528\uff0c\u662f\u4e00\u79cd\u6709\u524d\u666f\u7684\u764c\u75c7\u6cbb\u7597\u9776\u70b9\u3002\u4e00\u4e9b\u5316\u7597\u836f\u7269\u901a\u8fc7\u6291\u5236\u5fae\u7ba1\u805a\u5408\uff08\u5982\u957f\u6625\u65b0\u78b1\u548c\u957f\u6625\u82b1\u78b1\uff09\uff0c\u800c\u53e6\u4e00\u4e9b\u5219\u901a\u8fc7\u7a33\u5b9a\u5fae\u7ba1\uff08\u5982\u7d2b\u6749\u9187\u548c\u591a\u897f\u4ed6\u8d5b\uff09\uff0c\u5bfc\u81f4\u7ec6\u80de\u51cb\u4ea1\u548c\u5468\u671f\u963b\u6ede\u3002\u82ac\u82ef\u8fbe\u5511\u5728\u591a\u4e2a\u4eba\u7c7b\u764c\u7ec6\u80de\u7cfb\u4e2d\u663e\u793a\u51fa\u6291\u5236\u5fae\u7ba1\u805a\u5408\u6d3b\u6027\uff0c\u6291\u5236\u764c\u7ec6\u80de\u589e\u6b96\u5e76\u589e\u5f3a\u51cb\u4ea1\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u82ac\u82ef\u8fbe\u5511\u7684\u836f\u4ee3\u52a8\u529b\u5b66<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u7531\u4e8e\u82ac\u82ef\u8fbe\u5511\u5c1a\u672a\u83b7\u5f97\u5728\u4eba\u7c7b\u4e2d\u4f7f\u7528\u7684\u76d1\u7ba1\u6279\u51c6\uff0c\u5176\u4eba\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u6709\u9650\u3002\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6700\u8fd1\u6388\u4e88\u82ac\u82ef\u8fbe\u5511\u7684\u4e3b\u8981\u4ee3\u8c22\u7269\u6c27\u82ac\u8fbe\u5511\uff08oxfendazole\uff09\u5feb\u901f\u901a\u9053\u8ba4\u8bc1\uff0c\u7528\u4e8e\u6cbb\u7597\u4eba\u4f53\u6bdb\u9996\u97ad\u866b\u75c5\u3002\u5bf9\u6c27\u82ac\u8fbe\u5511\u7684\u836f\u7406\u5b66\u7814\u7a76\u6709\u52a9\u4e8e\u8865\u5145\u5bf9\u82ac\u82ef\u8fbe\u5511\u5728\u4eba\u7c7b\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u7406\u89e3\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u82ac\u82ef\u8fbe\u5511\u5728\u809d\u810f\u4e2d\u90e8\u5206\u5438\u6536\uff0c\u4e2d\u95f4\u4ee3\u8c22\u4ea7\u7269\u4e3a\u6c27\u82ac\u8fbe\u5511\uff08\u82ac\u82ef\u8fbe\u5511\u4e9a\u781c\uff09\uff0c\u7f9f\u57fa\u82ac\u82ef\u8fbe\u5511\uff0c\u548c\u82ac\u82ef\u8fbe\u5511\u781c\u3002\u5c3d\u7ba1\u7ed9\u836f\u540e\u82ac\u82ef\u8fbe\u5511\u781c\u5728\u8840\u6d46\u4e2d\u5360\u4e3b\u5bfc\u5730\u4f4d\uff0c\u4f46\u6c27\u82ac\u8fbe\u5511\u662f\u82ac\u82ef\u8fbe\u5511\u4e3b\u8981\u7684\u751f\u7269\u6d3b\u6027\u4ee3\u8c22\u4ea7\u7269\u3002<\/p>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c6\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c6\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND4X7ZPUQfzdMja8dQzXmEGKFzzNbicI2Bxjnchte35jAs8ST5avk57cbg\/640?wx_fmt=png&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=10005&amp;wx_lazy=1#imgIndex=3\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c7\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c7\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND4X7ZPUQfzdMja8dQzXmEGKFzzNbicI2Bxjnchte35jAs8ST5avk57cbg\/640?wx_fmt=png&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=10005&amp;wx_lazy=1#imgIndex=3\" \/><\/figure>\n<p class=\"wp-block-paragraph\">\u96c4\u6027\u5927\u9f20\u53e3\u670d\u7ed9\u836f\uff0c\u82ac\u82ef\u8fbe\u5511\u7684\u8840\u836f\u6d53\u5ea6\u4e0a\u9650\u4e3a0.32\u5fae\u514b\/\u6beb\u5347\u3002\u5728\u809d\u810f\u4ee3\u8c22\u540e\uff0c\u82ac\u82ef\u8fbe\u5511\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u901a\u8fc7\u7caa\u4fbf\u548c\u5c3f\u6db2\u6392\u6cc4\u3002\u725b\u53e3\u670d\u7ed9\u836f\u540e\uff0c36%\u7684\u82ac\u82ef\u8fbe\u5511\u5728\u7caa\u4fbf\u4e2d\u88ab\u56de\u6536\uff0c\u800c\u5c3f\u6db2\u4e2d\u672a\u53d1\u73b0\u4efb\u4f55\u6b8b\u7559\u7269\u3002\u5728\u9759\u8109\u7ed9\u836f\u65f6\uff0c\u8d85\u8fc750%\u7684\u82ac\u82ef\u8fbe\u5511\u5242\u91cf\u4ee5\u7f9f\u57fa\u82ac\u82ef\u8fbe\u5511\u7684\u5f62\u5f0f\u6392\u6cc4\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u5b89\u5168\u6027\u548c\u6bd2\u6027<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c\u82ac\u82ef\u8fbe\u5511\u663e\u793a\u51fa\u8f83\u9ad8\u7684\u5b89\u5168\u6027\u548c\u8f83\u4f4e\u7684\u6bd2\u6027\u3002\u5728\u4e00\u9879\u9488\u5bf9\u725b\u7684\u5b89\u5168\u6027\u7814\u7a76\u4e2d\uff0c\u5373\u4f7f\u4ee5\u5904\u65b9\u5242\u91cf\u7684\u516d\u500d\u548c\u63a8\u8350\u4f7f\u7528\u65f6\u957f\u7684\u4e09\u500d\u4f7f\u7528\u82ac\u82ef\u8fbe\u5511\uff0c\u52a8\u7269\u4f9d\u7136\u80fd\u591f\u826f\u597d\u8010\u53d7\u3002\u5728\u556e\u9f7f\u52a8\u7269\u4e2d\uff0c\u5176\u534a\u6570\u81f4\u6b7b\u5242\u91cf\uff08LD50\uff09\u8d85\u8fc710\u514b\/\u5343\u514b\uff0c\u8fd9\u76f8\u5f53\u4e8e\u6cbb\u7597\u6c34\u5e73\u76841000\u500d\u3002\u5728\u5927\u9f20\u7684\u7ec8\u751f\u7814\u7a76\u4e2d\uff0c\u672a\u53d1\u73b0\u6bcd\u4f53\u6216\u751f\u6b96\u6bd2\u6027\u53ca\u81f4\u764c\u6027\u3002<mark class=\"has-inline-color has-vivid-red-color\">\u7136\u800c\uff0c\u89c2\u5bdf\u5230\u809d\u7ec6\u80de\u80a5\u5927\u548c\u589e\u751f\u7684\u5f62\u6001\u5b66\u6539\u53d8\u3002<\/mark><\/p>\n<p class=\"wp-block-paragraph\">\u82ac\u82ef\u8fbe\u5511\u7684\u4e3b\u8981\u4ee3\u8c22\u4ea7\u7269\u6c27\u82ac\u8fbe\u5511\u5728\u4eba\u7c7b\u4e2d\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u5728\u4e00\u9879\u9488\u5bf970\u540d\u5065\u5eb7\u53d7\u8bd5\u8005\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u8bc4\u4f30\u4e86\u4ece0.5\u523060\u6beb\u514b\/\u5343\u514b\u7684\u6c27\u82ac\u8fbe\u5511\u591a\u79cd\u9012\u589e\u7684\u53e3\u670d\u5242\u91cf\u3002<mark class=\"has-inline-color 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Tippens\u7684\u4f8b\u5b50\u91cc\uff0cJoe\u5728\u53e3\u670d\u82ac\u82ef\u8fbe\u5511\u7684\u540c\u65f6\u8fd8\u670d\u7528\u4e86CBD\u6cb9\uff0c<strong>\u548c\u6cb9\u540c\u670d\u6709\u52a9\u4e8e\u82ac\u82ef\u8fbe\u5511\u7684\u5206\u6563\u6eb6\u89e3\uff0c\u5bf9\u5438\u6536\u53ef\u80fd\u6709\u6539\u5584\u4f5c\u7528<\/strong>\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u82ac\u82ef\u8fbe\u5511\u4f5c\u4e3a\u4eba\u7c7b\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5<\/strong>\u5c3d\u7ba1\u82ac\u82ef\u8fbe\u5511\u4f5c\u4e3a\u764c\u75c7\u6cbb\u7597\u836f\u7269\u5728\u7f3a\u4e4f\u76d1\u7ba1\u6279\u51c6\u548c\u5e7f\u6cdb\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e00\u4e9b\u764c\u75c7\u60a3\u8005\u5df2\u6839\u636e\u75c5\u4f8b\u62a5\u9053\u81ea\u884c\u4f7f\u7528\u8be5\u836f\u7269\u3002\u4e0b\u9762\u7684\u8868\u683c\u91cc\u4f8b\u4e3e\u4e86\u4e00\u4e9b\u75c5\u4f8b\u62a5\u544a\uff0c\u53e3\u670d\u82ac\u82ef\u8fbe\u5511\u5355\u836f\u6216\u4e0e\u5316\u7597\u836f\u8054\u7528\u90fd\u4f7f\u80bf\u7624\u7f29\u5c0f\uff0c\u4e00\u4f8b\u65e0\u6548\u3002<mark class=\"has-inline-color has-vivid-red-color\">\u6709\u4e24\u4e2a\u75c5\u4f8b\u51fa\u73b0\u4e86\u836f\u7269\u76f8\u5173\u7684\u809d\u529f\u80fd\u969c\u788d\uff0c\u809d\u529f\u80fd\u5728\u505c\u7528\u82ac\u82ef\u8fbe\u5511\u540e\u6062\u590d\u3002<\/mark><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c8\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c8\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND4v5kRPlUibNmTwy9wuIJwaEAsFTZ5CrQH3tn3gvk8aOSNXOHicKhuaicVA\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=10005&amp;wx_lazy=1#imgIndex=4\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c9\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c9\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND4v5kRPlUibNmTwy9wuIJwaEAsFTZ5CrQH3tn3gvk8aOSNXOHicKhuaicVA\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=10005&amp;wx_lazy=1#imgIndex=4\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c10\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c10\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND45ibtW1Rxp50nQM7hBSA6HhKjVFmSxgSNITVU6mic2cW94zwQR1OJkeCg\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=10005&amp;wx_lazy=1#imgIndex=5\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c11\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c11\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/ibcGoYgo7CfCPfYnFEhxSXZmNebKH0ND45ibtW1Rxp50nQM7hBSA6HhKjVFmSxgSNITVU6mic2cW94zwQR1OJkeCg\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=10005&amp;wx_lazy=1#imgIndex=5\"><\/p>\n<p class=\"wp-block-paragraph\">\u7531\u4e8e\u82ac\u82ef\u8fbe\u5511\u4ef7\u683c\u8f83\u4f4e\u4e14\u53ef\u5728\u67dc\u53f0\u8d2d\u4e70\uff0c\u4e00\u4e9b\u60a3\u8005\u5c06\u5176\u4f5c\u4e3a\u4e00\u79cd\u5bb6\u5ead\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u3002\u6839\u636e\u5df2\u53d1\u8868\u7684\u75c5\u4f8b\u62a5\u9053\uff0c\u6700\u5e38\u89c1\u7684\u81ea\u884c\u4f7f\u7528\u65b9\u6848\u662f<strong>\u6bcf\u5929\u53e3\u670d1\u514b\u82ac\u82ef\u8fbe\u5511\uff0c\u8fde\u7eed\u670d\u7528\u4e09\u5929\uff0c\u7136\u540e\u505c\u836f\u56db\u5929<\/strong>\u3002\u7136\u800c\uff0c\u82ac\u82ef\u8fbe\u5511\u4f5c\u4e3a\u4eba\u7c7b\u764c\u75c7\u6cbb\u7597\u836f\u7269\u7684\u4f7f\u7528\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u786e\u5b9a\u6709\u6548\u7684\u5242\u91cf\u548c\u65b9\u6848\u3002<mark class=\"has-inline-color has-vivid-red-color\">\u809d\u529f\u80fd\u53d7\u635f\u3001\u809d\u786c\u5316\u6216\u809d\u764c\u7684\u60a3\u8005\u5e94\u8c28\u614e\u4f7f\u7528\u82ac\u82ef\u8fbe\u5511\u3002\u6b64\u5916\uff0c\u5c06\u82ac\u82ef\u8fbe\u5511\u4e0e\u7cd6\u9175\u89e3\u6291\u5236\u5242\u548c\u4fdd\u809d\u836f\u7269\u6216\u8425\u517b\u8865\u5145\u5242\u8054\u5408\u4f7f\u7528\uff0c\u53ef\u4ea7\u751f\u534f\u540c\u7684\u6cbb\u7597\u6548\u679c\uff0c\u540c\u65f6\u51cf\u5c11\u6f5c\u5728\u7684\u809d\u6bd2\u6027\u3002<\/mark><\/p>\n<p class=\"wp-block-paragraph\">\n<h1 class=\"wp-block-heading\">\u82ac\u82ef\u8fbe\u5511\u6297\u80bf\u7624\u8c31\u3001\u6f5c\u5728\u5206\u5b50\u673a\u5236\u53ca\u53e3\u670d\u7eb3\u7c73\u836f\u7269\u7814\u53d1<\/h1>\n<p class=\"wp-block-paragraph\">\u539f\u521b \u7fdf\u5d07\u51ef\uff0c\u4ed8\u79c0\u8679\u7b49 \u7fdf\u5d07\u51ef\uff0c\u4ed8\u79c0\u8679\u7b49 <a href=\"void(0);\">\u4e2d\u56fd\u5408\u7406\u7528\u836f\u63a2\u7d22Chinahlyy<\/a> <em>2025\u5e745\u67089\u65e5 <\/em><\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>\u5f15\u7528\u6587\u672c<\/strong>: \u7fdf\u5d07\u51ef\uff0c\u6768\u5c11\u54f2\uff0c\u5f20\u6e05\u4f1f\uff0c\u5f20\u8d3a\u4f1f\uff0c\u4ed8\u79c0\u8679<sup>*<\/sup>.\u82ac\u82ef\u8fbe\u5511\u6297\u80bf\u7624\u8c31\u3001\u6f5c\u5728\u5206\u5b50\u673a\u5236\u53ca\u53e3\u670d\u7eb3\u7c73\u836f\u7269\u7814\u53d1[J].\u4e2d\u56fd\u5408\u7406\u7528\u836f\u63a2\u7d22\uff0c2025\uff0c22\uff084\uff09\uff1a1-11.<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u76ee\u7684\uff1a<\/strong>\u63a2\u7d22\u82ac\u82ef\u8fbe\u5511\uff08FBZ\uff09\u7684\u6297\u80bf\u7624\u8c31\uff0c\u57fa\u4e8e\u7f51\u7edc\u836f\u7406\u5b66\u4e0e\u5206\u5b50\u5bf9\u63a5\u6280\u672f\u89e3\u6790\u5176\u6cbb\u7597\u7ed3\u80a0\u764c\u7684\u6f5c\u5728\u4f5c\u7528\u673a\u5236\uff0c\u5e76\u5f00\u53d1\u5177\u5907\u826f\u597d\u53e3\u670d\u6027\u80fd\u7684FBZ\u7eb3\u7c73\u5236\u5242\uff0c\u52a9\u529bFBZ\u7684\u4e34\u5e8a\u5e94\u7528\u8f6c\u5316\u3002<strong>\u65b9\u6cd5\uff1a<\/strong>\u9996\u5148\u91c7\u7528CCK-8\u6cd5\u3001\u514b\u9686\u5f62\u6210\u5b9e\u9a8c\u53ca\u6d41\u5f0f\u7ec6\u80de\u672f\uff0c\u7b5b\u9009FBZ\u5bf97\u79cd\u5e38\u89c1\u80bf\u7624\u7c7b\u578b\uff08\u7ed3\u80a0\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u3001\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u548c\u80f0\u817a\u764c\uff099\u79cd\u7ec6\u80de\u7cfb\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff1b\u901a\u8fc7\u7f51\u7edc\u836f\u7406\u5b66\u548c\u5206\u5b50\u5bf9\u63a5\u65b9\u6cd5\uff0c\u521d\u6b65\u89e3\u6790\u5176\u4f5c\u7528\u4e8e\u7ed3\u80a0\u764c\u7684\u5173\u952e\u9776\u70b9\u4e0e\u4fe1\u53f7\u901a\u8def\uff1b\u5236\u5907\u57fa\u4e8e\u80c6\u9178\u76d0\u8f7d\u4f53\u7684FBZ\u53e3\u670d\u7eb3\u7c73\u836f\u7269\uff0c\u4ee5\u514b\u670d\u5176\u4f4e\u6c34\u6eb6\u6027\u9650\u5236\u3002<strong>\u7ed3\u679c\uff1a<\/strong>FBZ\u5bf9\u7ed3\u80a0\u764c\u7ec6\u80de\u7cfb\u7684\u6291\u5236\u6548\u679c\u6700\u663e\u8457\uff0c\u968f\u540e\u4f9d\u6b21\u4e3a\u524d\u5217\u817a\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u3001\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u53ca\u80f0\u817a\u764c\u3002\u7f51\u7edc\u836f\u7406\u5b66\u53d1\u73b06\u4e2a\u5173\u952e\u9776\u70b9\uff0c\u5373<em>BRAF\u3001KDR\u3001RAF1\u3001MMP1\u3001MAPK8\u548cMAPK14<\/em>\uff1bKEGG\u5bcc\u96c6\u4e3b\u8981\u901a\u8fc7\u764c\u75c7\u901a\u8def\u3001Rap1\u4fe1\u53f7\u901a\u8def\u3001VEGF\u4fe1\u53f7\u901a\u8def\u3001EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u8010\u836f\u901a\u8def\u3001MAPK\u4fe1\u53f7\u901a\u8def\u3001Relaxin\u4fe1\u53f7\u901a\u8def\u548cFoxO\u4fe1\u53f7\u901a\u8def\u7b49\u3002\u5206\u5b50\u5bf9\u63a5\u7ed3\u679c\u663e\u793a\uff0cFBZ\u4e0e\u9776\u86cb\u767d<em>MAPK14\u3001BRAF<\/em>\u53ca\u5176\u7a81\u53d8\u4f53<em>BRAF<\/em> V600E\u548c<em>RAF1<\/em>\u5177\u6709\u826f\u597d\u7684\u7ed3\u5408\u6d3b\u6027\u3002FBZ\u53e3\u670d\u7eb3\u7c73\u836f\u7269\u7c92\u5f84\u5927\u5c0f\u7ea6\u4e3a300 nm\uff0c\u6c34\u6eb6\u6027\u8fbe\u52300.5 mg\/ml\uff0c\u63d0\u9ad8\u4e86\u7ea6500\u500d\u3002<strong>\u7ed3\u8bba\uff1a<\/strong>FBZ \u5728\u4f53\u5916\u5bf9\u7ed3\u80a0\u764c\u7ec6\u80de\u8868\u73b0\u51fa\u6781\u9ad8\u7684\u654f\u611f\u6027\uff0c\u53ef\u80fd\u901a\u8fc7\u591a\u9776\u70b9\u3001\u591a\u901a\u8def\u534f\u540c\u4f5c\u7528\u6291\u5236\u80bf\u7624\u8fdb\u5c55\u3002\u5f00\u53d1\u7684\u53e3\u670d\u7eb3\u7c73\u5236\u5242\u663e\u8457\u6539\u5584\u5176\u6c34\u6eb6\u6027\uff0c\u4e3aFBZ\u6f5c\u5728\u7684\u4e34\u5e8a\u6297\u80bf\u7624\u7528\u836f\u63d0\u4f9b\u53c2\u8003\uff0c\u5e76\u4e3a\u672a\u6765\u7684\u8f6c\u5316\u7814\u7a76\u5960\u5b9a\u57fa\u7840\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>\u5173\u952e\u8bcd<\/strong>: \u82ac\u82ef\u8fbe\u5511\uff1b\u6297\u80bf\u7624\uff1b\u7f51\u7edc\u836f\u7406\u5b66\uff1b\u7ed3\u80a0\u764c\uff1b\u6c34\u6eb6\u6027\uff1b\u7eb3\u7c73\u836f\u7269<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\">\u82ac\u82ef\u8fbe\u5511\uff08fenbendazole\uff0c FBZ\uff09\u4f5c\u4e3a\u4e00\u79cd\u5e7f\u8c31\u82ef\u5e76\u54aa\u5511\u7c7b\u9a71\u866b\u836f\uff0c\u957f\u671f\u7528\u4e8e\u6cbb\u7597\u72ac\u3001\u732b\u7b49\u52a8\u7269\u7684\u5bc4\u751f\u866b\u611f\u67d3<sup>[1]<\/sup>\u3002\u8fd1\u5e74\u6765\uff0cFBZ\u56e0\u4e00\u5219\u300a\u764c\u75c7\u60a3\u8005\u201c\u4f7f\u7528\u72d7\u836f\u6297\u764c\u6210\u529f\u201d\u300b\u7684\u62a5\u9053\u800c\u5f15\u8d77\u5b66\u8005\u7684\u5e7f\u6cdb\u5173\u6ce8\uff0c\u4f7f\u5f97FBZ\u88ab\u91cd\u65b0\u5b9a\u4f4d\uff0c\u52a0\u901f\u5176\u8001\u836f\u65b0\u7528\u7814\u7a76\u8fdb\u7a0b<sup>[2]<\/sup>\u3002\u968f\u7740\u7814\u7a76\u7684\u4e0d\u65ad\u6df1\u5165\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0cFBZ\u9664\u4e86\u9a71\u866b\u6d3b\u6027\u5916\uff0c\u8fd8\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u6297\u80bf\u7624\u5019\u9009\u836f\u7269\u3002Peng\u7b49<sup>[3]<\/sup>\u53d1\u73b0FBZ\u901a\u8fc7\u79ef\u7d2f\u6d3b\u6027\u6c27\uff08reactive oxygen species\uff0cROS\uff09\u6765\u8bf1\u5bfc\u6c27\u5316\u5e94\u6fc0\uff0c\u6291\u5236HeLa\u7ec6\u80de\u7684\u589e\u6b96\u3002Wang\u7b49<sup>[4]<\/sup>\u53d1\u73b0FBZ\u53ef\u5242\u91cf\u4f9d\u8d56\u6027\u6291\u5236\u4eba\u5375\u5de2\u764c\u7ec6\u80deA2780\u548cSKOV3\u589e\u6b96\u3002FBZ\u901a\u8fc7\u9776\u5411\u7834\u574f\u5fae\u7ba1\u805a\u5408\u3001\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3001\u963b\u6ede\u7ec6\u80de\u5468\u671f\u3001\u6297\u8840\u7ba1\u751f\u6210\u548c\u963b\u65ad\u8461\u8404\u7cd6\u8f6c\u8fd0\u7b49\u6297\u80bf\u7624\u6d3b\u6027\u9776\u70b9\uff0c\u5e76\u6270\u4e71\u5185\u6e90\u6027\u51cb\u4ea1\u3001\u7ecf\u5178Wnt\/\u03b2-catenin\u3001JAK\/STAT-3\u3001JNK\u3001MEK\/ERK\u548chedgehog\u7b49\u591a\u79cd\u4fe1\u53f7\u901a\u8def\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528<sup>[5-6]<\/sup>\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0<sup>[7-8]<\/sup>\uff0cFBZ\u5bf95-\u6c1f\u5c3f\u5627\u5576\u8010\u836f\u7684\u80bf\u7624\u7ec6\u80deSNU-C5\u9ad8\u5ea6\u654f\u611f\uff0c\u8868\u660eFBZ\u5177\u6709\u4f5c\u4e3a\u4e00\u79cd\u5316\u7597\u836f\u7269\u8865\u5145\u4f50\u5242\u7684\u6f5c\u80fd\uff0c\u4e0e\u5e38\u89c4\u5316\u7597\u836f\u7269\u8054\u5408\u4f7f\u7528\u6709\u5229\u4e8e\u8010\u836f\u80bf\u7624\u7684\u6cbb\u7597\u548c\u964d\u4f4e\u80bf\u7624\u8010\u836f\u6027\u7684\u4ea7\u751f\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u5c3d\u7ba1FBZ\u5728\u4f53\u5916\u8bd5\u9a8c\u3001\u52a8\u7269\u6a21\u578b\u4e2d\u5bf9\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u5c55\u73b0\u51fa\u826f\u597d\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4f46\u76ee\u524d\u4ecd\u7f3a\u4e4f\u7cfb\u7edf\u6027\u7684\u5927\u6837\u672c\u4e34\u5e8a\u7814\u7a76\u4e0e\u5145\u5206\u7684\u673a\u5236\u9a8c\u8bc1\uff0c\u5c1a\u672a\u88ab\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08Food and Drug&nbsp;Administration\uff0cFDA\uff09\u6279\u51c6\u7528\u4e8e\u80bf\u7624\u6cbb\u7597<sup>[9]<\/sup>\u3002\u73b0\u9636\u6bb5\uff0c\u82ef\u5e76\u54aa\u5511\u7c7b\u836f\u7269\u5982\u7532\u82ef\u8fbe\u5511\u548c\u963f\u82ef\u8fbe\u5511\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u4eba\u7c7b\u5bc4\u751f\u866b\u611f\u67d3\u7684\u6cbb\u7597\uff0c\u4f46FBZ\u901a\u5e38\u4e0d\u4f5c\u4e3a\u4eba\u7c7b\u4e34\u5e8a\u5e38\u89c4\u7528\u836f\uff0c\u4ec5\u5728\u6781\u5c11\u6570\u60c5\u51b5\u4e0b\u88ab\u7eb3\u5165\u7f55\u89c1\u4eba\u7528\u5bc4\u751f\u866b\u75c5\u6cbb\u7597\u7684\u7814\u7a76\u8303\u7574\uff0c\u4e14FBZ\u5728\u4eba\u7c7b\u4e2d\u7684\u836f\u52a8\u5b66\u548c\u5b89\u5168\u6027\u5c1a\u672a\u5728\u4e34\u5e8a\u4e2d\u8fdb\u884c\u8be6\u7ec6\u7814\u7a76\uff0c\u6781\u5927\u5730\u963b\u788d\u4e86FBZ\u7684\u4e34\u5e8a\u5e94\u7528<sup>[10]<\/sup>\u3002\u9274\u4e8eFBZ\u524d\u671f\u5927\u91cf\u7684\u52a8\u7269\u5b9e\u9a8c\u8bc1\u5b9eFBZ\u5bf9\u591a\u79cd\u52a8\u7269\u5177\u6709\u8f83\u9ad8\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u7406\u8bba\u4e0a\u4f1a\u5927\u5927\u7f29\u77edFBZ\u8001\u836f\u65b0\u7528\u548c\u517d\u533b\u836f\u54c1\u5411\u4eba\u7c7b\u836f\u54c1\u518d\u5f00\u53d1\u7684\u7814\u53d1\u65f6\u95f4\u548c\u6210\u672c<sup>[11]<\/sup>\u3002\u6b64\u5916\uff0c\u7531\u4e8eFBZ\u7f3a\u4e4f\u4e00\u4e2a\u660e\u786e\u3001\u5e7f\u6cdb\u4e14\u7ecf\u8fc7\u7cfb\u7edf\u9a8c\u8bc1\u7684\u764c\u75c7\u6cbb\u7597\u8c31\uff0c\u4e5f\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u9650\u5236\u4e86\u5176\u5728\u80bf\u7624\u9886\u57df\u7684\u4e34\u5e8a\u836f\u7269\u5f00\u53d1\u4e0e\u8f6c\u5316\u5e94\u7528\u3002\u672c\u7814\u7a76\u62df\u901a\u8fc7\u91c7\u7528CCK-8\u6cd5\u3001\u514b\u9686\u5f62\u6210\u5b9e\u9a8c\u53ca\u6d41\u5f0f\u7ec6\u80de\u672f\uff0c\u7b5b\u9009FBZ\u5bf97\u79cd\u5e38\u89c1\u80bf\u7624\u7c7b\u578b\uff08\u7ed3\u80a0\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u3001\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u548c\u80f0\u817a\u764c\uff09\u7ec6\u80de\u7cfb\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u7ed8\u5236FBZ\u7684\u6297\u80bf\u7624\u8c31\uff0c\u5e76\u901a\u8fc7\u6bd4\u8f833\u79cd\u68c0\u6d4b\u65b9\u6cd5\u7684\u7279\u70b9\uff0c\u5efa\u7acb\u4e00\u79cd\u5feb\u901f\u4e14\u53ef\u9760\u7684\u8bc4\u4f30\u65b9\u6cd5\uff0c\u7528\u4e8e\u68c0\u6d4b\u80bf\u7624\u7ec6\u80de\u7cfb\u5bf9FBZ\u7684\u654f\u611f\u6027\uff0c\u4e3aFBZ\u4e34\u5e8a\u5e94\u7528\u63d0\u4f9b\u4f9d\u636e\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u7ed3\u80a0\u764c\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u5ea6\u5f02\u8d28\u6027\u7684\u6076\u6027\u80bf\u7624\uff0c\u5176\u53d1\u751f\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u4f34\u968f\u591a\u79cd\u9057\u4f20\u4e0e\u8868\u89c2\u9057\u4f20\u53d8\u5316\u3002\u5176\u4e2d\uff0c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08microsatellite instability\uff0cMSI\uff09\u548cKirsten\u5927\u9f20\u8089\u7624\u75c5\u6bd2\u764c\u57fa\u56e0\uff08Kirsten Rat Sarcoma Viral Oncogene Homolog <em>KRAS<\/em>\uff09\u7a81\u53d8\u662f\u6700\u5e38\u89c1\u4e14\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5206\u5b50\u4e8b\u4ef6\u3002MSI\u662f\u7531\u4e8e\u8131\u6c27\u6838\u7cd6\u6838\u9178\uff08deoxyribonucleic acid\uff0c<em>DNA<\/em>\uff09\u9519\u914d\u4fee\u590d\u7cfb\u7edf\u7f3a\u9677\u6240\u81f4\u7684\u57fa\u56e0\u4e0d\u7a33\u5b9a\uff0c\u7ea615%\u7684\u7ed3\u80a0\u764c\u60a3\u8005\u5b58\u5728MSI\uff0c\u4e0e\u80bf\u7624\u836f\u7269\u7684\u654f\u611f\u6027\u5bc6\u5207\u76f8\u5173<sup>[12]<\/sup>\u3002\u7ea6\u670935%~45%\u7684\u7ed3\u80a0\u764c\u60a3\u8005\u5b58\u5728<em>KRAS<\/em>\u57fa\u56e0\u7a81\u53d8\uff0c\u8be5\u7a81\u53d8\u4e3b\u8981\u96c6\u4e2d\u5728\u7b2c12\u548c13\u53f7\u5bc6\u7801\u5b50\u3002<em>KRAS<\/em>\u7a81\u53d8\u5bfc\u81f4\u6297\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08epidermal growth factor receptor\uff0c<em>EGFR<\/em>\uff09\u5355\u6297\u5728<em>KRAS<\/em>\u7a81\u53d8\u60a3\u8005\u4e2d\u7597\u6548\u663e\u8457\u964d\u4f4e<sup>[13]<\/sup>\u3002\u6b64\u5916\uff0c<em>BRAF<\/em>\u3001<em>PIK3CA<\/em>\u3001<em>TP53<\/em>\u3001<em>APC<\/em>\u7b49\u57fa\u56e0\u7684\u5f02\u5e38\u8868\u8fbe\u4e0e\u7ed3\u80a0\u764c\u5bc6\u5207\u76f8\u5173<sup>[14]<\/sup>\u3002Shimomura\u7b49<sup>[15]<\/sup>\u8bc1\u5b9eFBZ\u53ef\u9009\u62e9\u6027\u6291\u5236<em>KRAS<\/em>\u7a81\u53d8\u7684\u80ba\u764c\u7ec6\u80de\u3002\u4e3a\u4e86\u63a2\u660eFBZ\u6297\u7ed3\u80a0\u764c\u7684\u5206\u5b50\u673a\u5236\uff0c\u672c\u7814\u7a76\u91c7\u7528\u7f51\u7edc\u836f\u7406\u5b66\u4e0e\u5206\u5b50\u5bf9\u63a5\u6280\u672f\u89e3\u6790\u5176\u6cbb\u7597\u7ed3\u80a0\u764c\u7684\u6f5c\u5728\u4f5c\u7528\u673a\u5236\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u53e3\u670d\u7ed9\u836f\u4f5c\u4e3a\u4e00\u79cd\u5e38\u7528\u7684\u7ed9\u836f\u9014\u5f84\uff0c\u5177\u6709\u65b9\u4fbf\u3001\u7ecf\u6d4e\u3001\u5b89\u5168\u7684\u4f18\u70b9\uff0c\u7279\u522b\u9002\u7528\u4e8e\u9700\u8981\u957f\u671f\u7528\u836f\u7684\u764c\u75c7\u60a3\u8005\u3002FBZ\u5b58\u5728\u6c34\u6eb6\u6027\u548c\u751f\u7269\u5229\u7528\u7387\u4f4e\u7684\u95ee\u9898\uff0c\u4e25\u91cd\u963b\u788d\u4e86\u5176\u53e3\u670d\u836f\u7269\u7684\u5f00\u53d1<sup>[11]<\/sup>\u3002\u80c6\u9178\u76d0\u4f5c\u4e3a\u52a8\u7269\u673a\u4f53\u80a0\u9053\u5185\u7684\u5929\u7136\u6d3b\u6027\u7269\u8d28\uff0c\u6bd2\u6027\u8f83\u4f4e\u3002\u524d\u671f\u7814\u7a76\u8bc1\u5b9e<sup>[16]<\/sup>\uff0c\u4ee5\u80c6\u9178\u76d0\u4e3a\u8f7d\u4f53\u5236\u6210\u7684\u6c2f\u785d\u67f3\u80fa\u7eb3\u7c73\u836f\u7269\uff0c\u4e0d\u4ec5\u53ef\u4ee5\u63d0\u9ad8\u5176\u6c34\u6eb6\u6027\uff0c\u8fd8\u53ef\u4ee5\u5229\u7528\u80c6\u9178\u76d0\u8f6c\u8fd0\u7cfb\u7edf\u5feb\u901f\u5438\u6536\u76ee\u6807\u836f\u7269\u6c2f\u785d\u67f3\u80fa\u5165\u8840\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u751f\u7269\u5229\u7528\u7387\u3002\u672c\u7814\u7a76\u91c7\u7528\u57fa\u4e8e\u524d\u671f\u5f00\u53d1\u7684\u80c6\u9178\u76d0\u9012\u9001\u7cfb\u7edf\u5236\u5907FBZ\u53e3\u670d\u7eb3\u7c73\u836f\u7269\uff0c\u521d\u6b65\u8bc4\u4f30FBZ\u7684\u7eb3\u7c73\u5236\u5242\u7279\u5f81\uff0c\u4e3aFBZ\u7684\u4e34\u5e8a\u8f6c\u5316\u5e94\u7528\u63d0\u4f9b\u4e00\u5b9a\u7684\u7814\u7a76\u53c2\u8003\u3002\u57fa\u4e8e\u6b64\uff0c\u672c\u7814\u7a76\u65e8\u5728\u4e3a\u63a2\u660eFBZ\u7684\u6297\u80bf\u7624\u8c31\u3001\u6f5c\u5728\u5206\u5b50\u673a\u5236\u4ee5\u53ca\u5f00\u53d1FBZ\u53e3\u670d\u7eb3\u7c73\u836f\u7269\u7684\u4e34\u5e8a\u7814\u7a76\u63d0\u4f9b\u53c2\u8003\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>1<\/strong> <strong>\u6750\u6599\u548c\u65b9\u6cd5<\/strong><\/p>\n<p class=\"wp-block-paragraph\"><strong>1.1 \u7ec6\u80de\u548c\u8bd5\u5242<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u4e3a\u8bc4\u4f30FBZ\u7684\u6297\u80bf\u7624\u8c31\uff0c\u9009\u62e9\u4e86\u4ee3\u88687\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u76849\u79cd\u4eba\u80bf\u7624\u7ec6\u80de\uff0c\u5305\u62ec\u7ed3\u80a0\u764c\uff08HCT116\u548cHCT15\uff09\u3001\u80ba\u764c\uff08H460\uff09\u3001\u809d\u764c\uff08HepG2\uff09\u3001\u80f0\u817a\u764c\uff08SNU-213\uff09\u3001\u4e73\u817a\u764c\uff08Hs58T\u548cMDA-MB-231\uff09\u3001\u5375\u5de2\u764c\uff08SK-OV-3\uff09\u3001\u524d\u5217\u817a\u764c\uff08PC-3\uff09\uff0c\u4ee5\u53ca\u6b63\u5e38\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CCD-18C\u548cIMR-90\uff09\u7ec6\u80de\u7cfb\uff0c\u5747\u4fdd\u5b58\u4e8e\u6d1b\u9633\u804c\u4e1a\u6280\u672f\u5b66\u9662\u6cb3\u5357\u7701\u5730\u6807\u836f\u6750\u4e0e\u751f\u547d\u5065\u5eb7\u5de5\u7a0b\u7814\u7a76\u4e2d\u5fc3\u3002CCK-8\u8bd5\u5242\u76d2\u8d2d\u81eaAbcam\u516c\u53f8\uff0cDMEM\u57f9\u517b\u57fa\u8d2d\u81eaGibico\u516c\u53f8\uff0c\u80c6\u9178\u76d0\u548cFBZ\u8d2d\u81eaSigma\u516c\u53f8\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>1.2 CCK-8\u6cd5<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u7ec6\u80de\u4ee5\u6bcf\u5b541.0\u00d710<sup>4<\/sup>\u4e2a\u7ec6\u80de\u5728\u542b\u670910%FBS\u548c\u6297\u83cc\u836f\u7269\u7684DMEM\u57f9\u517b\u57fa\u4e2d\u63a5\u79cd\u4e8e96\u5b54\u677f\u4e2d\uff0c37\u2103\u5b75\u80b224 h\u3002\u52a0\u5165\u4e0d\u540c\u6d53\u5ea6\u7684\u836f\u7269\uff0c\u5e76\u572837\u2103\u4e0b\u5b75\u80b248 h\u3002\u4f7f\u7528CCK-8\u8bd5\u5242\u76d2\u6d4b\u91cf\u7ec6\u80de\u6d3b\u529b\uff0c\u4f9d\u636e\u8bf4\u660e\u8fdb\u884c\u64cd\u4f5c\u3002\u751f\u62108\u70b9\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\uff08dose-response curve\uff0cDRC\uff09\uff0c\u5316\u5408\u7269\u6d53\u5ea6\u8303\u56f4\u5728\u9002\u5f53\u6d53\u5ea6\u5185\u3002DRCs\u7531Prism 7\u4f7f\u7528S\u578b\u5242\u91cf-\u54cd\u5e94\u6a21\u578b\u8fdb\u884c\u62df\u5408\uff0c\u534a\u6570\u6291\u5236\u6d53\u5ea6\uff08half maximal inhibitory concentration\uff0cIC<sub>50<\/sub>\uff09\u503c\u5747\u6839\u636e\u5f52\u4e00\u5316\u6d3b\u6027\u6570\u636e\u96c6\u62df\u5408\u66f2\u7ebf\u8ba1\u7b97\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>1.3 \u514b\u9686\u5f62\u6210\u5b9e\u9a8c<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u53d6\u878d\u5408\u5ea6\u8d85\u8fc790%\u7684\u80bf\u7624\u7ec6\u80de\u8fdb\u884c\u6d88\u5316\u8ba1\u6570\u540e\uff0c\u8f6c\u79fb\u7ec6\u80de\u81f36\u5b54\u677f\u4e2d\uff0c\u6bcf\u5b54\u7ec6\u80de\u6570\u7ea610<sup>3<\/sup>\u4e2a\u7ec6\u80de\uff0c\u52a0\u5165\u4e0d\u540c\u6d53\u5ea6\u7684FBZ\uff0c\u7f6e\u4e8e37\u2103\uff0c5% CO<sub>2<\/sub>\u57f9\u517b\u7bb1\u4e2d\u57f9\u517b\u3002\u57f9\u517b1~2\u5468\u540e\uff0c\u5f53\u51fa\u73b0\u8089\u773c\u53ef\u89c1\u7684\u96c6\u843d\u65f6\uff0c\u53d6\u51fa\u7ec6\u80de\u57f9\u517b\u677f\uff0c\u5f03\u9664\u57f9\u517b\u6db2\uff0c\u6bcf\u5b54\u52a0\u51652 ml\u591a\u805a\u7532\u919b\u56fa\u5b9a30 min\uff0c\u5f03\u9664\u591a\u805a\u7532\u9187\uff0c\u6bcf\u5b54\u52a0\u51652 ml 0.1%\u7ed3\u6676\u7d2b\u67d3\u82723 min\uff0c\u7136\u540e\u6e05\u6d17\u6389\u7ed3\u6676\u7d2b\uff0c\u76f8\u673a\u62cd\u7167\u5e76\u8ba1\u7b97\u96c6\u843d\u6570\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>1.4 \u6d41\u5f0f\u7ec6\u80de\u672f<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u91c7\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u5feb\u901f\u7b5b\u9009FBZ\u5bf9\u4e0d\u540c\u80bf\u7624\u7ec6\u80de\u682a\u7684\u6bd2\u6027\u6548\u679c\u3002\u7ec6\u80de\u91cd\u60ac\u540e\u5728\u542b\u670910% FBS\u7684DMEM \u57f9\u517b\u57fa\u4e2d37\u2103\u4e0b\u57f9\u517b24 h\u540e\uff0c\u8fdb\u884c\u836f\u7269\u5904\u7406\u300224~48 h\u540e\u6536\u96c6\u7ec6\u80de\uff0c\u53c2\u7167LIVE\/DEAD<sup>TM&nbsp;<\/sup>Fixable Dead Cell Stain Kits\uff08\u8d5b\u9ed8\u98de\u516c\u53f8\uff0cCat No.L34960\uff09\u8bf4\u660e\u4e66\u67d3\u8272\u540e\uff0c\u5728Attune Nxt\u6d41\u5f0f\u7ec6\u80de\u4eea\uff08\u8d5b\u9ed8\u98de\u516c\u53f8\uff09\u4e2d\u8fdb\u884c\u68c0\u6d4b\u3002\u8be5\u8bd5\u5242\u76d2\u7684\u6d3b\u6027\u67d3\u6599\u53ef\u4ee5\u6e17\u900f\u6b7b\u7ec6\u80de\u7684\u7ec6\u80de\u819c\uff0c\u5e76\u5728\u7ec6\u80de\u5185\u90e8\u548c\u8868\u9762\u4e0e\u6e38\u79bb\u80fa\u53cd\u5e94\uff0c\u4ea7\u751f\u5f3a\u70c8\u7684\u8367\u5149\u3002\u7ed3\u679c\u91c7\u7528Flowjo\u8f6f\u4ef6\u8fdb\u884c\u5206\u6790\uff0c\u8ba1\u7b97\u7ec6\u80de\u7684\u6b7b\u4ea1\u7387\uff0c\u786e\u5b9a\u836f\u7269\u7684\u6297\u80bf\u7624\u6548\u679c\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>1.5 \u7f51\u7edc\u836f\u7406\u5b66\u9884\u6d4bFBZ\u6297\u7ed3\u80a0\u764c\u7684\u6f5c\u5728\u9776\u70b9\u53ca\u5206\u5b50\u673a\u5236<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u5728Pubmed\u4e0a\u4ee5fenbendazole\u548ccolon cancer\u4e3a\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22\uff0c\u521d\u6b65\u7b5b\u9009\u51fafenbendazole\u76f8\u5173\u7684\u4f5c\u7528\u9776\u70b9\u3002\u5728Pubchem\u6570\u636e\u5e93\u4e2d\u5c06fenbendazole\u6210\u5206\u4fdd\u5b58\u4e3a\u6807\u51c6\u5ef6\u8fdf\u683c\u5f0f\uff08standard delay format\uff0cSDF\uff09\u6587\u4ef6\u3002\u901a\u8fc7\u745e\u58eb\u9776\u70b9\u9884\u6d4b\uff08swiss target prediction\uff0cSTP\uff09\u6570\u636e\u5e93\u548c\u7ed3\u6784\u76f8\u4f3c\u6027\u9776\u70b9\u9884\u6d4b\uff08similarity ensemble approach\uff0cSEA\uff09\u6570\u636e\u5e93\u5bfc\u5165fenbendazole SDF\u6587\u4ef6\u67e5\u8be2\u6f5c\u5728\u4f5c\u7528\u9776\u70b9\u53ca\u57fa\u56e0\u4fe1\u606f\uff0c\u6700\u540e\u5c06\u9776\u70b9\u57fa\u56e0\u5408\u5e76\uff0c\u5220\u9664\u76f8\u540c\u57fa\u56e0\u4fdd\u7559\u552f\u4e00\u9879\u3002\u5728\u4eba\u7c7b\u5b5f\u5fb7\u5c14\u9057\u4f20\u5728\u7ebf\uff08Online Mendelian Inheritance in Man\uff0cOMIM\uff09\u6570\u636e\u5e93\u548c\u57fa\u56e0\u5361\u7247\uff08gene cards\uff09\u6570\u636e\u5e93\u4ee5colon cancer\u4e3a\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22\uff0c\u5408\u5e76\u76f8\u540c\u9879\u83b7\u5f97colon cancer\u76f8\u5173\u7684\u75c5\u6bd2\u9776\u70b9\u3002\u4f7f\u7528\u7ef4\u6069\u56fe\u7ed8\u5236\u5de5\u5177Venny 2.1.0\u627e\u51fa\u5316\u5408\u7269\u9776\u70b9\u548c\u75be\u75c5\u9776\u70b9\u4e4b\u95f4\u7684\u91cd\u53e0\u9776\u70b9\u3002\u5c06\u5316\u5408\u7269-\u75be\u75c5\u7684\u91cd\u53e0\u9776\u70b9\u6dfb\u52a0\u5230\u7528\u4e8e\u68c0\u7d22\u57fa\u56e0\/\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u641c\u7d22\u5de5\u5177\uff08search tool for the retrieval of interacting genes\/proteins\uff0cSTRING\uff09\u4e2d\uff0c\u7b5b\u9009\u6761\u4ef6\u4e3a\u201chomo sapiens\u201d\uff0c\u5e76\u4fdd\u5b58\u7ed3\u679c\u3002\u5c06\u7ed3\u679c\u6587\u4ef6\u5bfc\u5165\u5230Cytoscape v3.7.1\u8f6f\u4ef6\u4e2d\uff0c\u4f7f\u7528\u8f6f\u4ef6\u4e2d\u7684BisoGenet\u548cCytoNCA\u63d2\u4ef6\u8ba1\u7b97\u5ea6\u4e2d\u5fc3\u6027\uff08degree centrality\uff0cDC\uff09\u3001\u4ecb\u6570\u4e2d\u5fc3\u6027\uff08betweenness centrality\uff0cBC\uff09\u548c\u63a5\u8fd1\u4e2d\u5fc3\u6027\uff08closeness centrality\uff0cCC\uff09\u3002\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08protein-protein interaction\uff0cPPI\uff09\u7f51\u7edc\u7684\u6838\u5fc3\u9776\u70b9\u88ab\u7b5b\u9009\u51fa\u6765\u3002\u5229\u7528\u6ce8\u91ca\u3001\u53ef\u89c6\u5316\u4e0e\u7efc\u5408\u53d1\u73b0\u6570\u636e\u5e93\uff08Database for Annotation,Visualization and Integrated Discovery\uff0cDAVID\uff09\u8fdb\u884c\u57fa\u56e0\u672c\u4f53\uff08geneon tology\uff0cGO\uff09\u5bcc\u96c6\u548c\u4eac\u90fd\u57fa\u56e0\u4e0e\u57fa\u56e0\u7ec4\u767e\u79d1\u5168\u4e66\uff08Kyoto Encyclopedia of Genes and Genomes Pathway Analysis\uff0cKEGG\uff09\u901a\u8def\u5206\u6790\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>1.6 \u5206\u5b50\u5bf9\u63a5\u6a21\u62df\u9a8c\u8bc1FBZ\u7684\u5173\u952e\u9776\u70b9<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u4f7f\u7528Schrodinger Maestro\u8f6f\u4ef6\u8bc4\u4ef7\u5173\u952e\u9776\u86cb\u767d\u548cFBZ\u7684\u7ed3\u5408\u80fd\u529b\u3002\u5728\u5bf9\u63a5\u4e4b\u524d\uff0c\u4ece\u86cb\u767d\u8d28\u6570\u636e\u5e93\uff08protein data bank\uff0cPDB\uff09\u4e0b\u8f7d\u9776\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\uff083 dimensions\uff0c3D\uff09\u7ed3\u6784\uff0c\u5e76\u4f7f\u7528\u8f6f\u4ef6\u5185ligGprep\u6a21\u5757\u6784\u5efa\u5316\u5408\u7269\u76843D \u7ed3\u6784\u3002\u53d7\u4f53\u86cb\u767d\u8d28\u4f7f\u7528Protein Preparation Workflow\u6a21\u5757\uff0c\u4f18\u5316\u6c28\u57fa\u9178\u548c\u53bb\u9664\u6c34\u5206\u5b50\u548c\u6742\u8d28\u3002\u6700\u540e\u91c7\u7528Ligand Docking\u6a21\u5757\u8fdb\u884c\u5206\u5b50\u5bf9\u63a5\u5206\u6790\u3002<\/p>\n<p class=\"wp-block-paragraph\"><strong>1.7 FBZ\u7eb3\u7c73\u53e3\u670d\u836f\u7269\u7684\u5236\u5907\u53ca\u7279\u6027<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u5c06\u5236\u5907\u768410 mg\/ml FBZ \u4e8c\u7532\u4e9a\u781c\uff08dimethyl sulfoxide\uff0cDMSO\uff09\u6eb6\u6db2\uff0c\u6309\u6307\u5b9a\u4f53\u79ef\u6bd4\uff08FBZ\u2236\u80c6\u9178=1\u22365\uff09\u5feb\u901f\u52a0\u516510 mg\/ml\u80c6\u9178\u94a0\u6eb6\u6db2\u4e2d\u3002\u91c7\u7528SCIENTZ-IID\u8d85\u58f0\u6ce2\u7834\u788e\u4eea\uff08\u65b0\u829d\u751f\u7269\uff09\uff0c\u5c06\u6eb6\u6db2\u6df7\u5408\u7269\u5728100 W\u4e0b\u8d85\u58f060 s\uff0c\u4ea7\u751f\u7eb3\u7c73\u7c92\u5b50\u3002\u8d85\u58f0\u5904\u7406\u540e\uff0c\u901a\u8fc7\u771f\u7a7a\u84b8\u53d1\u53bb\u9664\u6eb6\u5242\u3002\u6700\u540e\uff0c\u5c06\u7eb3\u7c73\u7c92\u5b50\u91cd\u65b0\u60ac\u6d6e\u5728\u8d85\u7eaf\u6c34\u3002\u91c7\u7528Zetasizer Nano-ZS90\u7eb3\u7c73\u7c92\u5ea6\u4eea\uff08\u9a6c\u5c14\u6587\u5e15\u7eb3\u79d1\u516c\u53f8\uff09\u6d4b\u5b9a\u7eb3\u7c73\u7c92\u5f84\uff1b\u91c7\u7528Jasco UV\/Vis V-770\u7d2b\u5916\u5206\u5149\u5149\u5ea6\u8ba1\uff08\u4f73\u53f8\u79d1\u516c\u53f8\uff09\u6d4b\u5b9aFBZ\u7684\u6eb6\u89e3\u5ea6\uff08\u5438\u6536\u5cf0\u4e3a293 nm\uff09\u3002<\/p>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>2<\/strong> <strong>\u7ed3\u679c<\/strong><\/p>\n<p class=\"wp-block-paragraph\"><strong>2.1 FBZ\u6297\u80bf\u7624\u6548\u679c<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u91c7\u75283\u79cd\u4e0d\u540c\u68c0\u6d4b\u65b9\u6cd5\u8bc4\u4f30\u4e86FBZ\u5bf9\u4e0d\u540c\u80bf\u7624\u7ec6\u80de\u7cfb\u7684\u6297\u80bf\u7624\u6548\u679c\u3002CCK-8\u68c0\u6d4b\u7ed3\u679c\u5982\u88681\u548c\u56fe1\u6240\u793a\uff0cFBZ\u5bf9\u6240\u6709\u7684\u80bf\u7624\u7ec6\u80de\u7cfb\u5747\u663e\u793a\u51fa\u6291\u5236\u6548\u679c\uff0c\u800c\u5bf9\u6b63\u5e38\u5bf9\u7167\u7ec6\u80de\u7cfb\u7684\u6bd2\u6027\u8f83\u5c0f\uff0cIC<sub>50<\/sub>\u8d85\u51fa\u68c0\u6d4b\u8303\u56f4\u3002\u5bf9\u7ed3\u80a0\u764c\u7684\u6291\u5236\u6548\u679c\u6700\u4f73\uff0cIC<sub>50<\/sub>\u7ea6\u4e3a400 nmol\/L\uff0c\u5176\u6b21\u4e3a\u524d\u5217\u817a\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u3001\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u548c\u80f0\u817a\u764c\u3002\u5bf9\u7167\u7ec4\u4e3a\u6b63\u5e38\u7ed3\u80a0\u6210\u7ea4\u7ef4\u7ec6\u80deCCD-18C\u548c\u6b63\u5e38\u80ba\u6210\u7ea4\u7ef4\u7ec6\u80deIMR-90\uff0c\u57282000 nmol\/L\u6d53\u5ea6\u4e0b\u672a\u89c2\u5bdf\u5230\u660e\u663e\u7684\u7ec6\u80de\u6bd2\u6027\u3002\u514b\u9686\u5f62\u6210\u5b9e\u9a8c\u7ed3\u679c\u57fa\u56e0\u663e\u793a\uff08\u56fe2A\uff09\uff0c500 nmol\/L FBZ\u5bf9\u6240\u6709\u80bf\u7624\u7ec6\u80de\u7cfb\u5747\u663e\u793a\u826f\u597d\u7684\u6291\u5236\u6548\u679c\uff08\u56fe2B\uff09\u3002\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0cFBZ\u5bf9\u7ed3\u80a0\u764c\u7684\u6291\u5236\u6548\u679c\u5177\u6709\u6781\u663e\u8457\u7684\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08<em>P<\/em>&lt;0.01\uff09\uff0cFBZ\u5bf9\u7ed3\u80a0\u764c\u7ec6\u80de\u7cfb\u7684\u6291\u5236\u6548\u679c\u4e0e\u80ba\u764c\u3001\u809d\u764c\u3001\u524d\u5217\u817a\u764c\u7ec6\u80de\u7cfb\u5177\u6709\u663e\u8457\u7684\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08<em>P<\/em>&lt;0.05\uff09\uff0c\u4e0e\u5176\u4f59\u80bf\u7624\u7ec6\u80de\u7cfb\u5177\u6709\u6781\u663e\u8457\u7684\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08<em>P<\/em>&lt;0.01\uff09\u3002\u6d41\u5f0f\u7ec6\u80de\u672f\u68c0\u6d4b\u4e86FBZ\uff08500 nmol\/L\uff09\u7684\u7ec6\u80de\u6b7b\u4ea1\u7387\uff08\u56fe3A\uff09\uff0cFBZ \u5bf9\u7ed3\u80a0\u764c\u7ec6\u80de\u7cfb\u7684\u81f4\u6b7b\u7387\u6700\u9ad8\uff0c\u4e0e\u80ba\u764c\u7ec6\u80de\u7cfb\u5177\u6709\u663e\u8457\u7684\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08<em>P<\/em>&lt;0.05\uff09\uff0c\u4e0e\u5176\u4f59\u80bf\u7624\u7ec6\u80de\u7cfb\u5177\u6709\u6781\u663e\u8457\u7684\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08<em>P<\/em>&lt;0.01\uff09\uff08\u56fe3B\uff09\u30023\u79cd\u68c0\u6d4b\u65b9\u6cd5\u5747\u663e\u793a\uff0cFBZ\u5bf9\u7ed3\u80a0\u764c\u7ec6\u80de\u7cfb\u7684\u654f\u611f\u6027\u6700\u5f3a\uff0c\u5176\u4f59\u80bf\u7624\u7ec6\u80de\u7cfb\u5bf9FBZ\u7684\u654f\u611f\u6027\u7ed3\u679c\u57fa\u672c\u4e00\u81f4\u3002\u8868\u660e\u672c\u7814\u7a76\u5f00\u53d1\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u80fd\u591f\u7528\u4e8e\u5feb\u901f\u68c0\u6d4b\u4e0d\u540c\u80bf\u7624\u7cfb\u5bf9FBZ\u7684\u654f\u611f\u6027\uff0c\u4e3a\u540e\u671fFBZ\u5728\u4e34\u5e8a\u4e2d\u7684\u5e94\u7528\u5960\u5b9a\u57fa\u7840\u3002<\/p>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c12\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c12\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1NAwLrotcjEBf3PTFJpGzicuUfLHZmia4gbaSrnOPYGS8HbMPO2uK2WRQ\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=0\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c13\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c13\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1NAwLrotcjEBf3PTFJpGzicuUfLHZmia4gbaSrnOPYGS8HbMPO2uK2WRQ\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=0\" \/><\/figure>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c14\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c14\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1icvhA9aqiaxLmwyHcwDFkQqWj97icxqnbhveiaHzhiaSfIP6ibpatbtOib8FA\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=1\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c15\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c15\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1icvhA9aqiaxLmwyHcwDFkQqWj97icxqnbhveiaHzhiaSfIP6ibpatbtOib8FA\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=1\" \/><\/figure>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c16\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c16\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1mV8bg5Btp3XlkIWjyglGalJWOF8ejn9icNe5QDNcUiaJuQAtavbtPOcA\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=2\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c17\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c17\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1mV8bg5Btp3XlkIWjyglGalJWOF8ejn9icNe5QDNcUiaJuQAtavbtPOcA\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=2\" \/><\/figure>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c18\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c18\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1orVQwEL4RhHThHueJNUQvOZHZWwBQcMVo9NwP84FqggYDJRfGcmhNQ\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=3\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c19\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c19\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1orVQwEL4RhHThHueJNUQvOZHZWwBQcMVo9NwP84FqggYDJRfGcmhNQ\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=3\" \/><\/figure>\n<p class=\"wp-block-paragraph\"><strong>2.2 \u7f51\u7edc\u836f\u7406\u5b66\u5206\u6790<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u7f51\u7edc\u836f\u7406\u5b66\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0cFBZ-\u7ed3\u80a0\u764c\u9776\u70b9\u53d6\u4ea4\u96c6\u540e\uff08\u56fe4A\uff09\u5171\u5f97\u52306\u4e2a\u9776\u70b9<em>BRAF\u3001KDR\u3001<\/em><em>RAF1\u3001MMP1\u3001MAPK8<\/em>\u548c<em>MAPK14<\/em>\uff0c\u8fdb\u4e00\u6b65\u7b5b\u9009\u53d1\u73b0<em>MAPK14<\/em>\u3001<em>BRAF<\/em>\u548c<em>RAF1<\/em>\u53ef\u80fd\u4e3aFBZ\u9ad8\u6548\u9776\u5411\u6027\u6cbb\u7597\u7ed3\u80a0\u764c\u7684\u9776\u86cb\u767d\u3002\u5728\u7ed3\u80a0\u764c\u53d1\u5c55\u8fdb\u7a0b\u4e2d\uff0c<em>MAPK14\u3001BRAF<\/em>\u548c<em>RAF1<\/em>\u7b49\u9776\u70b9\u8d77\u7740\u91cd\u8981\u4f5c\u7528\uff08\u56fe4B\uff09\uff0c\u53ef\u80fd\u662fFBZ\u6cbb\u7597\u7ed3\u80a0\u764c\u7684\u6f5c\u5728\u4f5c\u7528\u9776\u70b9\u3002\u56e0\u6b64\uff0c\u9776\u5411<em>MAPK14<\/em>\u3001<em>BRAF<\/em>\u548c<em>RAF1<\/em>\u53ef\u80fd\u4e3a\u7ed3\u80a0\u764c\u6cbb\u7597\u63d0\u4f9b\u4e00\u79cd\u5177\u6709\u524d\u666f\u7684\u65b0\u7b56\u7565\u3002GO\u5bcc\u96c6\u5206\u6790\u53ef\u77e5\uff08\u56fe4C\uff09\uff0cFBZ\u6297\u7ed3\u80a0\u764c\u7684\u9776\u57fa\u56e0\u6d89\u53ca\u4e1d\u88c2\u539f\u6fc0\u6d3b\u86cb\u767d\u9176\uff08mitogen-activated protein kinase\uff0cMAPK\uff09\u6d3b\u6027\u8c03\u8282\u3001\u7ed3\u5408\u86cb\u767d\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u6fc0\u9176\u6d3b\u6027\u8c03\u8282\u3001\u7ec6\u80de\u51cb\u4ea1\u8c03\u63a7\u3001\u86cb\u767d\u8d28\u78f7\u9178\u5316\u8c03\u63a7\u548c\u4e09\u78f7\u9178\u817a\u82f7\uff08adenosine triphosphate\uff0c ATP\uff09\u80fd\u91cf\u4ee3\u8c22\u7b49\u751f\u7269\u8fc7\u7a0b\u3002KEGG\u7ed3\u679c\u663e\u793a\uff08\u56fe4D\uff09\uff0c\u5171\u5bcc\u96c636\u6761\u4fe1\u53f7\u901a\u8def\uff0c\u5982\u764c\u75c7\u901a\u8def\u3001Rap1\u4fe1\u53f7\u901a\u8def\u3001VEGF\u4fe1\u53f7\u901a\u8def\u3001EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u8010\u836f\u901a\u8def\u3001MAPK\u4fe1\u53f7\u901a\u8def\u3001Relaxin\u4fe1\u53f7\u901a\u8def\u548cFoxO\u4fe1\u53f7\u901a\u8def\u7b49\u3002<\/p>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c20\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c20\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1T0Jr7ymKKbC8nSvR6ic7x7iax7WHaQjbNEPt8E0n5XYDUBLQRYiayEdVg\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=4\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c21\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c21\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1T0Jr7ymKKbC8nSvR6ic7x7iax7WHaQjbNEPt8E0n5XYDUBLQRYiayEdVg\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=4\" \/><\/figure>\n<p class=\"wp-block-paragraph\"><strong>2.3 \u5206\u5b50\u5bf9\u63a5<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u91c7\u7528Schrodinger Maestro\u8f6f\u4ef6\u8fdb\u884c\u5206\u5b50\u5bf9\u63a5\uff0cFBZ\u4e0e\u9776\u70b9\u86cb\u767d<em>MAPK14\u3001BRAF<\/em>\u53ca\u5176\u7a81\u53d8\u4f53<em>BRAF<\/em> V600E\u3001<em>RAF1<\/em>\u7684\u4eb2\u548c\u503c\u5206\u522b\u4e3a-5.76\u3001-7.01\u3001-6.99 \u548c-5.41\u3002FBZ\u4e0e\u9776\u70b9\u86cb\u767d<em>MAPK14<\/em>\u3001<em>BRAF<\/em>\u53ca\u5176\u7a81\u53d8\u4f53<em>BRAF<\/em> V600E\u3001<em>RAF1<\/em>\u7b49\u6709\u826f\u597d\u7684\u7ed3\u5408\u6d3b\u6027\uff0c\u8868\u660eFBZ\u53ef\u80fd\u901a\u8fc7\u6291\u5236<em>MAPK14<\/em>\u3001<em>BRAF<\/em>\u53ca\u5176\u7a81\u53d8\u4f53<em>BRAF <\/em>V600E\u3001<em>RAF1<\/em>\u6d3b\u6027\u6765\u53d1\u6325\u6297\u7ed3\u80a0\u764c\u4f5c\u7528\uff08\u56fe5\uff09\u3002<\/p>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c22\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c22\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY17nDRl8ChjTGhM0K7sibn2h8DgVmS1ib8lvFuibrKdMIq2lsa5E53RNtNw\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=5\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c23\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c23\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY17nDRl8ChjTGhM0K7sibn2h8DgVmS1ib8lvFuibrKdMIq2lsa5E53RNtNw\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=5\" \/><\/figure>\n<p class=\"wp-block-paragraph\"><strong>2.4 \u53e3\u670d\u7eb3\u7c73\u836f\u7269\u7684\u5236\u5907\u53ca\u7279\u6027<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u7531\u4e8eFBZ\u7684\u6c34\u6eb6\u6027\u8f83\u5dee\uff0c\u6781\u5927\u5730\u9650\u5236\u4e86\u5176\u6297\u80bf\u7624\u836f\u7269\u7684\u5e94\u7528\u3002\u672c\u7814\u7a76\u5f00\u53d1\u7684FBZ\u7eb3\u7c73\u9897\u7c92\uff0c\u7c92\u5f84\u5927\u5c0f\u4e3a300 nm\uff0c\u6c34\u6eb6\u6027\u4ece0.9 \u03bcg\/ml\u63d0\u9ad8\u81f30.5 mg\/ml\uff0c<\/p>\n<p class=\"wp-block-paragraph\">\u63d0\u9ad8\u4e86\u7ea6500\u500d\uff08\u56fe6\uff09\u3002<\/p>\n<figure class=\"wp-block-image\"><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c24\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c24\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"\/\/www.w3.org\/2000\/svg&#039;%20width=&#039;0&#039;%20height=&#039;0&#039;%20viewBox=&#039;0%200%200%200&#039;%3E%3C\/svg%3E\" class=\"perfmatters-lazy\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1NVmArzkmlPkXHaYibhPBkicEbaESriaMbBMia21tYyTb3eibezfRv7k2lMg\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=6\" \/><img decoding=\"async\" title=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c25\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" alt=\"\u4f0a\u7ef4\u83cc\u7d20\u4e0e\u82ac\u82ef\u8fbe\u5511 - \u7b2c25\u5f20  | \u4e2d\u836f\u517b\u751f\u77e5\u8bc6-\u4e2d\u8349\u836f\u7684\u529f\u6548\u4e0e\u4f5c\u7528\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/dYQOq0yvTtAkmYNXhKVdTBfyhpQVZmY1NVmArzkmlPkXHaYibhPBkicEbaESriaMbBMia21tYyTb3eibezfRv7k2lMg\/640?wx_fmt=jpeg&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=6\" \/><\/figure>\n<p class=\"wp-block-paragraph\">\n<p class=\"wp-block-paragraph\"><strong>3<\/strong> <strong>\u8ba8\u8bba<\/strong><\/p>\n<p class=\"wp-block-paragraph\">\u82ef\u5e76\u54aa\u5511\u7c7b\u836f\u7269\u5982\u963f\u82ef\u8fbe\u5511\u3001\u7532\u82ef\u8fbe\u5511\u53caFBZ\uff0c\u957f\u671f\u4f5c\u4e3a\u5e7f\u8c31\u6297\u5bc4\u751f\u866b\u836f\u7269\u7528\u4e8e\u52a8\u7269\u53ca\u4eba\u7c7b\u5bc4\u751f\u866b\u75c5\u7684\u9632\u6cbb\u3002FBZ\u6700\u521d\u4f5c\u4e3a\u517d\u533b\u4e34\u5e8a\u4e13\u7528\u836f\u7269\uff0c\u5728\u6cbb\u7597\u7ebf\u866b\u3001\u94a9\u866b\u7b49\u80a0\u9053\u5bc4\u751f\u866b\u4e2d\u663e\u793a\u51fa\u9ad8\u6548\u3001\u5b89\u5168\u548c\u826f\u597d\u7684\u8010\u53d7\u6027<sup>[1]<\/sup>\u3002\u82ef\u5e76\u54aa\u5511\u7c7b\u5177\u6709\u7c7b\u4f3c\u4e8e\u5929\u7136\u560c\u5464\u6838\u82f7\u9178\u7684\u7ed3\u6784\uff0c\u5f88\u5bb9\u6613\u4e0e\u4ee3\u8c22\u6d3b\u52a8\u7684\u591a\u79cd\u6548\u5e94\u5206\u5b50\u53d1\u751f\u7ed3\u5408<sup>[8]<\/sup>\u3002\u82ef\u5e76\u54aa\u5511\u7c7b\u836f\u7269\u6297\u5bc4\u751f\u866b\u7684\u4f5c\u7528\u673a\u5236\u4e3a\u963b\u65ad\u5bc4\u751f\u866b\u548c\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u7684\u5fae\u7ba1\u7cfb\u7edf\uff0c\u6291\u5236\u8461\u8404\u7cd6\u6444\u53d6\u548c\u8f6c\u8fd0\uff0c\u6700\u7ec8\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1<sup>[17]<\/sup>\u3002\u7814\u7a76\u53d1\u73b0<sup>[18]<\/sup>\uff0c\u82ef\u5e76\u54aa\u5511\u7c7b\u836f\u7269\u5177\u6709\u6297\u80bf\u7624\u7684\u65b0\u578b\u836f\u7406\u6d3b\u6027\uff0c\u9010\u6e10\u5f15\u8d77\u7814\u7a76\u8005\u4eec\u5bf9\u5176\u4f5c\u4e3a\u6f5c\u5728\u6297\u764c\u836f\u7269\u7684\u63a2\u7d22\u5174\u8da3\uff0c\u4e14\u76ee\u524d\u591a\u79cd\u82ef\u5e76\u54aa\u5511\u7c7b\u836f\u7269\uff08\u5982FBZ\u3001\u7532\u82ef\u8fbe\u5511\u3001\u963f\u82ef\u8fbe\u5511\u7b49\uff09\u5df2\u88ab\u4f5c\u4e3a\u6297\u764c\u836f\u7269\u91cd\u65b0\u5ba1\u89c6\u3002\u8001\u836f\u65b0\u7528\u4f5c\u4e3a\u4e00\u79cd\u6709\u4ef7\u503c\u7684\u5f00\u53d1\u66ff\u4ee3\u7b56\u7565\uff0c\u5176\u5019\u9009\u836f\u7269\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\u7684\u836f\u52a8\u5b66\u3001\u836f\u6548\u5b66\u548c\u5b89\u5168\u6027\u7279\u5f81\u5b8c\u5584\uff0c\u4f1a\u5927\u5927\u52a0\u901f\u836f\u7269\u7814\u53d1\u548c\u4e34\u5e8a\u6279\u51c6\u8fdb\u7a0b\u3002\u76ee\u524d\u5df2\u521d\u6b65\u8bc1\u5b9e\u4e86\u82ef\u5e76\u54aa\u5511\u7c7b\u5728\u4f53\u5916\u548c\u52a8\u7269\u6a21\u578b\u4e2d\u5bf9\u809d\u764c\u3001\u80ba\u764c\u3001\u5375\u5de2\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u4e73\u817a\u764c\u3001\u5934\u9888\u764c\u548c\u9ed1\u8272\u7d20\u7624\u6709\u8f83\u5f3a\u7684\u6291\u5236\u6d3b\u6027<sup>[19]<\/sup>\u3002\u7532\u82ef\u8fbe\u5511\u548c\u963f\u82ef\u8fbe\u5511\u4f5c\u4e3a\u4eba\u7c7b\u4e34\u5e8a\u5e38\u7528\u7684\u5e7f\u8c31\u9a71\u866b\u836f\uff0c\u5728\u9ad8\u5242\u91cf\u6297\u80bf\u7624\u7814\u7a76\u4e2d\u7532\u82ef\u8fbe\u5511\u6bd4\u963f\u82ef\u8fbe\u5511\u663e\u793a\u51fa\u66f4\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u963f\u82ef\u8fbe\u5511\u5177\u6709\u8f83\u5f3a\u6bd2\u6027\uff0c\u5e76\u5bfc\u81f4\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11<sup>[20]<\/sup>\u3002\u5728\u9ad3\u6bcd\u7ec6\u80de\u7624\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u9ed1\u8272\u7d20\u7624\u7684\u556e\u9f7f\u52a8\u7269\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\uff0c\u9ad8\u5242\u91cf\u53e3\u670d\u7532\u82ef\u8fbe\u5511\u53ef\u6709\u6548\u6291\u5236\u80bf\u7624\u8fdb\u5c55<sup>[21]<\/sup>\u3002\u90e8\u5206\u4e34\u5e8a\u75c5\u4f8b\u7814\u7a76\u4e5f\u53d1\u73b0\u7532\u82ef\u8fbe\u5511\u80fd\u591f\u6709\u6548\u7f13\u89e3\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u548c\u7ed3\u80a0\u764c\u8fdb\u7a0b\uff0c\u5e76\u80fd\u591f\u589e\u5f3a\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u653e\u5c04\u6cbb\u7597\u6548\u679c\uff0c\u8868\u660e\u7532\u82ef\u8fbe\u5511\u5177\u6709\u826f\u597d\u7684\u6297\u80bf\u7624\u6548\u679c<sup>[22-23]<\/sup>\u3002\u7136\u800c\u4e34\u5e8a\u7814\u7a76\u53d1\u73b0\uff0c\u53e3\u670d\u9ad8\u5242\u91cf\u7532\u82ef\u8fbe\u5511\uff084 g\/d\uff09\uff0c\u53ea\u670950%\u60a3\u8005\u7684\u8840\u836f\u6d53\u5ea6\u80fd\u591f\u8fbe\u5230\u6cbb\u7597\u7684\u6700\u4f4e\u6d53\u5ea6\u8981\u6c42\uff08300 ng\/ml\uff09\uff0c\u6781\u5927\u9650\u5236\u4e86\u4e34\u5e8a\u5e94\u7528<sup>[24]<\/sup>\u3002\u5c3d\u7ba1FBZ\u5728\u4e34\u5e8a\u4e0a\u4e5f\u5b58\u5728\u8840\u836f\u6d53\u5ea6\u4e0d\u8db3\u7684\u95ee\u9898\uff0c\u4f46FBZ\u5728\u82ef\u5e76\u54aa\u5511\u7c7b\u4e2d\u7684\u6297\u80bf\u7624\u6548\u679c\u6700\u4f73\uff0c\u5c24\u5176\u662f\u5728\u8010\u836f\u6027\u80bf\u7624\u7684\u6cbb\u7597\u4e2d\u663e\u793a\u51fa\u5de8\u5927\u7684\u5e94\u7528\u524d\u666f\u3002Shimomura\u7b49<sup>[15]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0cFBZ\u5bf9<em>KRAS<\/em>\u7a81\u53d8\u80ba\u764c\u7ec6\u80de\u7684\u6291\u5236\u4f5c\u7528\u6bd4\u5176\u4ed6\u82ef\u5e76\u54aa\u5511\u884d\u751f\u7269\u66f4\u5f3a\u3002Elmaaty\u7b49<sup>[25]<\/sup>\u53d1\u73b0FBZ\u5bf9\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\u578b\uff08vascular endothelial growth factor receptor 2\uff0cVEGFR-2\uff09\u62ee\u6297\u4f5c\u7528\u5f3a\u4e8e\u7532\u82ef\u8fbe\u5511\uff0c\u80fd\u591f\u6709\u6548\u6291\u5236\u80bf\u7624\u8840\u7ba1\u7684\u5f62\u6210\u3002Jung\u7b49<sup>[26]<\/sup>\u53d1\u73b0FBZ\u80fd\u591f\u901a\u8fc7\u4f5c\u7528\u4e8e\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f531\uff08programmed&nbsp;death-ligand 1\uff0cPD-L1\uff09\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\u3002\u6b64\u5916\uff0cFBZ\u56e0\u5176\u4f4e\u6210\u672c\u3001\u9ad8\u5b89\u5168\u6027\u548c\u72ec\u7279\u591a\u9014\u5f84\u6297\u589e\u6b96\u6d3b\u6027\uff0c\u6210\u4e3a\u82ef\u5e76\u54aa\u5511\u7c7b\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u9996\u9009<sup>[9]<\/sup>\u3002<\/p>\n<p class=\"wp-block-paragraph\">FBZ\u4f5c\u4e3a\u4e00\u79cd\u517d\u533b\u6297\u5bc4\u751f\u866b\u836f\u7269\u7684\u91cd\u65b0\u8bc4\u4f30\uff0c\u52a0\u901f\u4e86\u5176\u8001\u836f\u65b0\u7528\u7684\u6297\u80bf\u7624\u7814\u7a76\u8fdb\u7a0b\u3002\u9274\u4e8eFBZ\u901a\u5e38\u6700\u521d\u4e0d\u4f5c\u4e3a\u4eba\u7c7b\u4e34\u5e8a\u7528\u836f\uff0c\u5728\u4e34\u5e8a\u6297\u80bf\u7624\u7814\u7a76\u4e2d\u7f3a\u4e4f\u4e00\u4e2a\u5e7f\u6cdb\u3001\u5b89\u5168\u7684\u6297\u80bf\u7624\u8c31\u3002\u672c\u7814\u7a76\u901a\u8fc7CCK-8\u3001\u514b\u9686\u5f62\u6210\u5b9e\u9a8c\u53ca\u6d41\u5f0f\u7ec6\u80de\u672f\u7b5b\u9009\u53d1\u73b0FBZ\u5bf9\u7ed3\u80a0\u764c\u7684\u6291\u5236\u6548\u679c\u6700\u597d\uff0c\u5176\u6b21\u4e3a\u524d\u5217\u817a\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u3001\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u548c\u80f0\u817a\u764c\u3002\u5f00\u53d1\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u80fd\u591f\u5bf9\u4e0d\u540c\u80bf\u7624\u7684\u7ec6\u80de\u7cfb\u8fdb\u884c\u5feb\u901f\u7b5b\u9009\uff0c\u7ed3\u679c\u4e0e\u4f20\u7edf\u7684CCK-8\u3001\u514b\u9686\u5f62\u6210\u5b9e\u9a8c\u7ed3\u679c\u57fa\u672c\u4e00\u81f4\u3002\u6b64\u5916\uff0c\u53d1\u73b0\u5177\u6709\u591a\u91cd\u8010\u836f\u6027\u7684\u7ed3\u80a0\u80bf\u7624\u7ec6\u80de\u7cfbHCT15\u7684IC<sub>50<\/sub>\u4e0eHCT116\u7684IC<sub>50<\/sub>\u76f8\u4f3c\uff0c\u800c\u7d2b\u6749\u9187\u5bf9HCT15\u7684IC<sub>50<\/sub>\u8f83HCT116\u7684IC<sub>50<\/sub>\u9ad8\u7ea6200\u500d\uff0c\u63d0\u793aFBZ\u53ef\u80fd\u901a\u8fc7\u975eTUBB3\u9014\u5f84\u6291\u5236\u5fae\u7ba1\u5f62\u6210\uff0c\u6216\u901a\u8fc7\u5176\u4ed6\u673a\u5236\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528<sup>[27]<\/sup>\u3002\u7f51\u7edc\u836f\u7406\u5b66\u5206\u6790\u663e\u793a\uff0cFBZ\u53ef\u80fd\u901a\u8fc7<em>RAF1<\/em>\u7b49\u9776\u70b9\u6291\u5236\u5fae\u7ba1\u7684\u5f62\u6210\uff0c\u63d0\u793aFBZ\u5728\u6297\u7ed3\u80a0\u764c\u4ee5\u53ca\u80bf\u7624\u8010\u836f\u6027\u65b9\u9762\u5177\u6709\u5de8\u5927\u7684\u6f5c\u529b\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u7ed3\u80a0\u764c\u4f5c\u4e3a\u5168\u7403\u53d1\u75c5\u7387\u4e0e\u6b7b\u4ea1\u7387\u7b2c3\u4f4d\u7684\u6076\u6027\u80bf\u7624\uff0c\u6cbb\u7597\u8d39\u7528\u6602\u8d35\uff0c\u7ed9\u793e\u4f1a\u548c\u533b\u7597\u7cfb\u7edf\u5e26\u6765\u4e86\u6c89\u91cd\u7684\u8d1f\u62c5<sup>[14]<\/sup>\u3002MSI\u548c<em>KRAS<\/em>\u57fa\u56e0\u7a81\u53d8\u4e0e\u7ed3\u80a0\u764c\u4e34\u5e8a\u7528\u836f\u548c\u9884\u540e\u5177\u6709\u9ad8\u5ea6\u76f8\u5173\u6027<sup>[12-13]<\/sup>\u3002\u672c\u7814\u7a76\u5e94\u7528\u7684\u7ed3\u80a0\u764c\u7ec6\u80de\u7cfb\u4e3aHCT116\u548cHCT15\uff0c\u4e24\u8005\u7684MSI\u68c0\u6d4b\u7ed3\u679c\u5747\u4e3aMSI-High\uff0cHCT116\u662f<em>hMLH1<\/em>\u57fa\u56e0\u7eaf\u5408\u65e0\u610f\u4e49\u7a81\u53d8\uff0cHCT15\u662f<em>MSH6<\/em>\u7a81\u53d8\uff0c\u63d0\u793a\u5bf9\u5e38\u7528\u5316\u7597\u836f\u7269\u4e0d\u654f\u611f<sup>[28]<\/sup>\u3002\u9274\u4e8eMSI-High\u578b\u7ed3\u76f4\u80a0\u764c\u4e34\u5e8a\u6cbb\u7597\u4e2d\u9762\u4e34\u7684\u836f\u7269\u654f\u611f\u6027\u4e0d\u8db3\u95ee\u9898\uff0c\u672c\u7814\u7a76\u8fdb\u4e00\u6b65\u63a2\u7d22\u4e86FBZ\u5728\u8be5\u7c7b\u7ed3\u80a0\u764c\u7ec6\u80de\u7cfb\u4e2d\u7684\u6f5c\u5728\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u901a\u8fc7\u7f51\u7edc\u836f\u7406\u5b66\u548c\u5206\u5b50\u5bf9\u63a5\u63a2\u8ba8\u5176\u4f5c\u7528\u673a\u5236\uff0c\u65e8\u5728\u4e3a\u8be5\u7c7b\u96be\u6cbb\u6027\u80bf\u7624\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u601d\u8def\u3002\u7f51\u7edc\u836f\u7406\u5b66\u5206\u6790\u53d1\u73b0\uff0cFBZ\u6297\u7ed3\u80a0\u764c\u7684\u9776\u57fa\u56e0\u6d89\u53caMAPK\u6fc0\u9176\u6d3b\u6027\u8c03\u8282\u3001\u7ed3\u5408\u86cb\u767d\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u6fc0\u9176\u6d3b\u6027\u8c03\u8282\u3001\u7ec6\u80de\u51cb\u4ea1\u8c03\u63a7\u3001\u86cb\u767d\u8d28\u78f7\u9178\u5316\u8c03\u63a7\u548cATP\u80fd\u91cf\u4ee3\u8c22\u7b49\u751f\u7269\u8fc7\u7a0b\u3002KEGG\u7ed3\u679c\u663e\u793a\uff0c\u5171\u5bcc\u96c636\u6761\u4fe1\u53f7\u901a\u8def\uff0c\u5982\u764c\u75c7\u901a\u8def\u3001Rap1\u4fe1\u53f7\u901a\u8def\u3001VEGF\u4fe1\u53f7\u901a\u8def\u3001EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u8010\u836f\u901a\u8def\u3001MAPK\u4fe1\u53f7\u901a\u8def\u3001Relaxin\u4fe1\u53f7\u901a\u8def\u548cFoxO\u4fe1\u53f7\u901a\u8def\u7b49\u3002\u5206\u5b50\u5bf9\u63a5\u7ed3\u679c\u663e\u793a\uff0cFBZ\u7684\u4e3b\u8981\u9776\u57fa\u56e0<em>MAPK14<\/em>\u3001<em>BRAF<\/em>\u53ca\u7a81\u53d8\u4f53<em>BRAF<\/em>&nbsp;V600E\u548c<em>RAF1<\/em>\u4e0eFBZ\u5177\u6709\u826f\u597d\u7684\u7ed3\u5408\u6d3b\u6027\u3002Ariey-Bonnet\u7b49<sup>[29]<\/sup>\u4f53\u5916\u7814\u7a76\u53d1\u73b0\uff0c\u7532\u82ef\u8fbe\u5511\u80fd\u591f\u4f5c\u4e3a\u6709\u6548\u7684MAPK14\u6291\u5236\u5242\u3002\u672c\u7814\u7a76\u4e5f\u901a\u8fc7\u5206\u5b50\u5bf9\u63a5\u9a8c\u8bc1\u4e86FBZ\u4f5c\u4e3a\u4e00\u79cd\u6709\u6f5c\u529b\u7684MAPK14\u6291\u5236\u5242\u3002BRAF\u662fEGFR\u4fe1\u53f7\u901a\u8def\u4e2d\u91cd\u8981\u4fe1\u53f7\u5206\u5b50\uff0c\u5176\u7a81\u53d8\u53ef\u5bfc\u81f4MAPK\u901a\u8def\u4e0b\u6e38\u6301\u7eed\u6027\u6fc0\u6d3b\uff0c\u5f15\u8d77\u80bf\u7624\u7ec6\u80de\u5206\u5316\u3001\u589e\u503c\u3001\u4ee3\u8c22\u53ca\u751f\u957f\u6539\u53d8<sup>[30]<\/sup>\uff0c\u662f\u7ed3\u80a0\u764c\u91cd\u8981\u7684\u8d1f\u5411\u9884\u540e\u56e0\u5b50\u3002<em>BRAF<\/em> V600E\u662f\u7ed3\u80a0\u764c\u6700\u91cd\u8981\u7684\u7a81\u53d8\uff0c\u7a81\u53d8\u7387\u7ea6\u4e3a10%\uff0c\u7a81\u53d8\u540e\u5bfc\u81f4BRAF\u86cb\u767d\u5355\u4f53\u6d3b\u5316\u4ee5\u53ca\u540e\u7eedMEK1\u548cMEK2\u86cb\u767d\u6d3b\u5316\uff0c\u4fc3\u8fdb\u7ec6\u80de\u589e\u6b96\u548c\u6291\u5236\u7ec6\u80de\u51cb\u4ea1<sup>[31]<\/sup>\u3002HCT15\u4e3a\u975e<em>BRAF<\/em>\u7a81\u53d8\u7ec6\u80de\uff0cHCT116\u4e3a<em>BRAF<\/em>\u7a81\u53d8\u7ec6\u80de\uff0c\u63d0\u793aHCT15\u548cHCT116\u53ef\u80fd\u5bf9\u5316\u7597\u836f\u7269\u7684\u654f\u611f\u5ea6\u5dee\u5f02\u8f83\u5927<sup>[32]<\/sup>\u3002\u5206\u5b50\u5bf9\u63a5\u7ed3\u679c\u663e\u793a\uff0cFBZ\u80fd\u591f\u9776\u5411<em>BRAF<\/em>\u53ca\u7a81\u53d8\u4f53<em>BRAF<\/em> V600E\uff0c\u4e14\u5176\u5bf9\u7a81\u53d8\u578b<em>BRAF<\/em> V600E \u7684\u5bf9\u63a5\u5206\u6570\u7565\u9ad8\u4e8e\u91ce\u751f\u578b<em>BRAF<\/em>\uff0c\u8fd9\u89e3\u91ca\u4e86FBZ\u5bf9HCT15\u7684IC<sub>50<\/sub>\u7565\u9ad8\u4e8eHCT116\u3002Garc\u00eda-Alonso\u7b49<sup>[33]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0c\u9776\u5411RAF1\u86cb\u767d\u53ef\u8bf1\u5bfc\u5927\u591a\u6570\u80bf\u7624\u6d88\u9000\uff0c\u4e14\u65e0\u660e\u663e\u6bd2\u6027\u3002\u4e0a\u8ff0\u7ed3\u679c\u8868\u660e\uff0cFBZ\u5177\u6709\u4f5c\u4e3a<em>MAPK14<\/em>\u3001<em>BRAF<\/em>\u53ca\u7a81\u53d8\u4f53<em>BRAF<\/em> V600E\u548c<em>RAF1<\/em>\u6291\u5236\u5242\u7684\u5de8\u5927\u6f5c\u80fd\u3002<\/p>\n<p class=\"wp-block-paragraph\"><mark class=\"has-inline-color has-vivid-red-color\">\u5c3d\u7ba1FBZ\u5c55\u73b0\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6f5c\u529b\uff0c\u4f46\u56e0\u5176\u6c34\u6eb6\u6027\u5dee\uff08\u51e0\u4e4e\u4e0d\u6eb6\uff09\u548c\u751f\u7269\u5229\u7528\u5ea6\u4f4e\uff08\u7ea620%\uff09\uff0c\u6781\u5927\u9650\u5236\u4e86\u53e3\u670d\u5236\u5242\u7684\u5f00\u53d1\u4e0e\u4e34\u5e8a\u8f6c\u5316<sup>[11]<\/sup>\uff0c\u4e14\u4e2a\u4f53\u5438\u6536\u5dee\u5f02\u5927\uff0c\u90e8\u5206\u60a3\u8005\u65e0\u6cd5\u5728\u4e34\u5e8a\u53e3\u670d\u5242\u91cf\u4e0b\u8fbe\u5230\u6297\u764c\u7684\u8840\u836f\u6d53\u5ea6<sup>[9]<\/sup>\u3002<\/mark>\u4e3a\u4e86\u514b\u670dFBZ\u7684\u4e0a\u8ff0\u95ee\u9898\uff0c\u91c7\u7528\u4e0d\u540c\u7b56\u7565\u5df2\u7814\u7a76\u5f00\u53d1\u51fa\u591a\u79cd\u7eb3\u7c73\u836f\u7269\uff0c\u4f46\u5176\u6297\u80bf\u7624\u6548\u679c\u53c2\u5dee\u4e0d\u9f50\uff0c\u4e14\u5b58\u5728\u6f5c\u5728\u7684\u809d\u810f\u6bd2\u6027\u98ce\u9669<sup>[34-35]<\/sup>\u3002\u80c6\u9178\u76d0\u662f\u673a\u4f53\u80a0\u9053\u4e2d\u5929\u7136\u5b58\u5728\u7684\u6d3b\u6027\u6210\u5206\uff0c\u4f5c\u4e3a\u836f\u7269\u4f50\u5242\u7684\u751f\u7269\u6bd2\u6027\u8f83\u4f4e\u3002\u6b64\u5916\uff0c\u80c6\u9178\u76d0\u5177\u6709\u5206\u5b50\u4e24\u4eb2\u6027\uff0c\u800c\u80a0\u9053\u5185\u5b58\u5728\u9ad8\u6548\u7684\u80c6\u9178\u76d0\u9012\u9001\u8f7d\u4f53\uff0c\u4e3a\u5f00\u53d1\u57fa\u4e8e\u80c6\u9178\u76d0\u8f7d\u4f53\u7684\u7eb3\u7c73\u836f\u7269\u63d0\u4f9b\u4e86\u826f\u597d\u7684\u751f\u7269\u5b66\u57fa\u7840\u3002\u57fa\u4e8e\u80c6\u9178\u76d0\u9012\u9001\u7cfb\u7edf\u5236\u5907\u7684\u7eb3\u7c73\u5236\u5242\u4e0d\u4ec5\u80fd\u591f\u63d0\u9ad8\u836f\u7269\u7684\u6c34\u6eb6\u6027\uff0c\u8fd8\u53ef\u501f\u52a9\u80c6\u9178\u76d0\u8f6c\u8fd0\u673a\u5236\u4fc3\u8fdb\u76ee\u6807\u836f\u7269\u5728\u80a0\u9053\u4e2d\u7684\u5feb\u901f\u5438\u6536\uff0c\u4ece\u800c\u663e\u8457\u63d0\u5347\u751f\u7269\u5229\u7528\u5ea6\u3002\u524d\u671f\u7814\u7a76\u8868\u660e<sup>[16]<\/sup>\uff0c\u80c6\u9178\u76d0\u7eb3\u7c73\u8f7d\u4f53\u53ef\u6709\u6548\u5c06\u6c2f\u785d\u67f3\u80fa\u5feb\u901f\u9012\u9001\u81f3\u5168\u8eab\uff0c\u5e76\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u6297COVID-19\u6548\u679c\u3002\u63d0\u793a\u80c6\u9178\u76d0\u9012\u9001\u7cfb\u7edf\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7eb3\u7c73\u5e73\u53f0\uff0c\u5728\u4fdd\u969c\u836f\u7269\u5b89\u5168\u6027\u7684\u540c\u65f6\uff0c\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u8102\u6eb6\u6027\u836f\u7269\u7684\u6c34\u6eb6\u6027\u548c\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5177\u6709\u826f\u597d\u7684\u5e94\u7528\u524d\u666f\u3002\u672c\u7814\u7a76\u4ee5\u80c6\u9178\u76d0\u4e3a\u8f7d\u4f53\uff0c\u6784\u5efa\u4e86\u5305\u88abFBZ\u7684\u7eb3\u7c73\u836f\u7269\uff0c\u5176\u9897\u7c92\u7ea6\u4e3a300 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