{"id":66323,"date":"2026-03-17T05:11:11","date_gmt":"2026-03-17T05:11:11","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=66323"},"modified":"2026-03-17T05:11:11","modified_gmt":"2026-03-17T05:11:11","slug":"%e7%bb%84%e7%bb%87%e5%ad%a6%e4%b8%8e%e7%97%85%e7%90%86%e5%ad%a6%ef%bc%9a%e7%bb%93%e7%bc%94%e7%bb%84%e7%bb%876%ef%bc%88%e5%9b%ba%e6%80%81%e7%9a%84%e7%bb%93%e7%bc%94%e7%bb%84%e7%bb%87%ef%bc%9a%e8%bd%af","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=66323","title":{"rendered":"\u7ec4\u7ec7\u5b66\u4e0e\u75c5\u7406\u5b66\uff1a\u7ed3\u7f14\u7ec4\u7ec76\uff08\u56fa\u6001\u7684\u7ed3\u7f14\u7ec4\u7ec7\uff1a\u8f6f\u9aa8\u548c\u9aa8\uff0c\u9aa8\u6298\u6108\u5408\uff09"},"content":{"rendered":"<p>                                        \u4e00\u3001\u8f6f\u9aa8\u8f6f\u9aa8\uff08cartilage\uff09\u4e3a\u8f6f\u9aa8\u7ec4\u7ec7\u7684\u7b80\u79f0\uff0c\u7531\u8f6f\u9aa8\u7ec6\u80de\u548c\u7ec6\u80de\u5916\u57fa\u8d28\uff08\u8f6f\u9aa8\u57fa\u8d28\uff09\u7ec4\u6210\u3002\u8f6f\u9aa8\u7ec6\u80de\u88ab\u8f6f\u9aa8\u57fa\u8d28\uff08\u51dd\u80f6\u72b6\u6001\uff0c\u542b\u7ea4\u7ef4\u6210\u5206\uff09\u5305\u57cb\u5206\u7c7b\uff1a\u7ea4\u7ef4\u6210\u5206\u900f\u660e\u8f6f\u9aa8(Hyaline Cartilage)\u5f39\u6027\u8f6f\u9aa8(Elastic Cartilage)\u7ea4\u7ef4\u8f6f\u9aa8(Fibrous Cartilage)\uff1a\u8f6f\u9aa8\u5185\u65e0\u8840\u7ba1\u3001\u6dcb\u5df4\u7ba1\u548c\u795e\u7ecf\u3002\u5176\u8425\u517b\u6765\u81ea\u57fa\u8d28\u7684\u6e17\u900f\u8f6f\u9aa8\u6709\u4e00\u5b9a\u786c\u5ea6\u548c\u5f39\u6027\uff0c\u662f\u80da\u80ce\u65f6\u671f\u4e3b\u8981\u652f\u67b6\u6210\u5206\u3002\u65b0\u751f\u513f\u6c38\u4e45\u6027\u8f6f\u9aa8\u4e3b\u8981\u5728\u5916\u8033\u3001\u547c\u5438\u9053\u3001\u690e\u95f4\u76d8\u3001\u80f8\u5ed3\u548c\u5173\u8282\u7b49\u5904\uff08\u4e00\uff09\u900f\u660e\u8f6f\u9aa8\u65b0\u9c9c\u65f6\u5448\u534a\u900f\u660e\u6d45\u84dd\u8272\uff0c\u4f53\u5185\u5206\u5e03\u5e7f\uff1b\u57fa\u8d28\u591a\uff0c\u7ea4\u7ef4\u4e3a\u80f6\u539f\u539f\u7ea4\u7ef4\uff0c\u6297\u538b\u6027\u5f3a\uff0c\u6709\u5f39\u6027\u548c\u97e7\u6027\u9aa8\u67b6\u5916\u900f\u660e\u8f6f\u9aa8\uff1a\u9f3b\u808b\u9aa8\u3001\u5589\u8f6f\u9aa8\u5927\u90e8\u5206\u3001\u6c14\u7ba1\u548c\u652f\u6c14\u7ba1\u6811\u5185\u7684\u8f6f\u9aa8\u7b49\u4eba\u6c14\u7ba1\u900f\u660e\u8f6f\u9aa8\u9aa8\u67b6\u5185\u900f\u660e\u8f6f\u9aa8\uff1a\u808b\u8f6f\u9aa8\u548c\u5173\u8282\u8f6f\u9aa81 \u8f6f\u9aa8\u7ec6\u80de\uff08chondrocyte\uff09&nbsp; &nbsp; &nbsp; &nbsp;&nbsp;\u4f4d\u4e8e\u4e0e\u5176\u5f62\u72b6\u76f8\u540c\u7684\u8f6f\u9aa8\u57fa\u8d28\u5c0f\u8154\uff08\u8f6f\u9aa8\u9677\u7a9d\uff0ccartilage lacuna\uff09\u5185\u7d27\u9760\u8f6f\u9aa8\u9677\u7a9d\u7684\u8f6f\u9aa8\u57fa\u8d28\u4e2d\u786b\u9178\u8f6f\u9aa8\u7d20\uff08Chondroitin sulfate\uff0cCS\uff09\u8f83\u591a\uff0cHE\u67d3\u8272\u5f3a\u55dc\u78b1\u6027\uff0c\u79f0\u8f6f\u9aa8\u56ca\uff08cartilage capsule\uff09\u751f\u6d3b\u72b6\u6001\u65f6\u8f6f\u9aa8\u7ec6\u80de\u5145\u6ee1\u8f6f\u9aa8\u9677\u7a9d\uff0cHE\u67d3\u8272\u5207\u7247\u4e0a\uff0c\u7ec6\u80de\u56e0\u8131\u6c34\u6536\u7f29\u800c\u5448\u4e0d\u89c4\u5219\u7684\u5f62\u72b6\uff0c\u8f6f\u9aa8\u56ca\u4e0e\u7ec6\u80de\u4e4b\u95f4\u6709\u8f83\u5927\u7684\u7a7a\u9699\u3002\u9760\u8fd1\u8f6f\u9aa8\u819c\u7684\u8f6f\u9aa8\u7ec6\u80de\u8f83\u5e7c\u7a1a\uff0c\u4f53\u79ef\u5c0f\uff0c\u6241\u5706\u5f62\uff0c\u957f\u8f74\u4e0e\u8f6f\u9aa8\u8868\u9762\u5e73\u884c\uff0c\u5355\u4e2a\u5206\u5e03\u8d8a\u63a5\u8fd1\u8f6f\u9aa8\u5185\u90e8\uff0c\u8f6f\u9aa8\u7ec6\u80de\u8d8a\u5927\uff0c\u66f4\u4f3c\u5706\u5f62\uff0c\u6210\u7fa4\u5206\u5e03\uff0c2~8\u4e2a\u4e0d\u7b49\uff0c\u6bcf\u4e2a\u8f6f\u9aa8\u7ec6\u80de\u90fd\u6709\u81ea\u5df1\u7684\u8f6f\u9aa8\u9677\u7a9d\u548c\u8f6f\u9aa8\u56ca\u3002\u540c\u4e00\u7fa4\u8f6f\u9aa8\u7ec6\u80de\u7531\u5468\u8fb9\u7684\u4e00\u4e2a\u5e7c\u7a1a\u8f6f\u9aa8\u7ec6\u80de\u5206\u88c2\u589e\u6b96\u800c\u6210\uff0c\u79f0\u540c\u6e90\u7ec6\u80de\u7fa4\uff08isogenous group\uff09\u6210\u719f\u6216\u8f83\u6210\u719f\u7684\u8f6f\u9aa8\u7ec6\u80de\u6838\u504f\u5fc3\u4f4d\uff0c\u8f83\u5c0f\uff0c\u5706\u5f62\u6216\u692d\u5706\u5f62\uff0c\u6838\u4ec11\u81f3\u6570\u4e2a\u3002\u80de\u8d28\u5f31\u55dc\u78b1\u6027\uff0c\u4e2d\u5fc3\u4f53\uff08centrosome\uff09\u548c\u9ad8\u5c14\u57fa\u590d\u5408\u4f53\uff08Golgi complex\uff09\u8fd1\u6838\u5206\u5e03\uff0c\u7ebf\u7c92\u4f53\uff08mitochondrion\uff09\u6563\u5728\u4e8e\u80de\u8d28\uff0c\u53ef\u89c1\u7cd6\u539f(glycogen)\u3001\u8272\u7d20\u9897\u7c92\uff08pigment granules\uff09\u548c\u6570\u91cf\u4e0d\u7b49\u7684\u8102\u6ef4&nbsp;(Lipid droplets, LDs)&nbsp;\uff08\u5207\u7247\u5448\u8f83\u5c0f\u7684\u7a7a\u6ce1\u72b6\uff09\u751f\u957f\u671f\u7684\u8f6f\u9aa8\u7ec6\u80de\u55dc\u78b1\u6027\u589e\u5f3a\u7535\u955c\u4e0b\uff0c\u8f6f\u9aa8\u7ec6\u80de\u8868\u9762\u6709\u7a81\u8d77\u548c\u76b1\u8936\uff0c\u80de\u8d28\u5185\u7c97\u9762\u5185\u8d28\u7f51(rough endoplasmic reticulum, RER)&nbsp;\u5927\uff0c\u9ad8\u5c14\u57fa\u590d\u5408\u4f53\u53d1\u8fbe\u3002\u751f\u957f\u4e2d\u7684\u8f6f\u9aa8\u819c\u9ad8\u5c14\u57fa\u590d\u5408\u4f53\u589e\u5927\uff0c\u5927\u6ce1\u5185\u53ef\u89c1\u9897\u7c92\u72b6\u548c\u7ec6\u4e1d\u72b6\u5206\u6ccc\u7269\u8d28\uff0c\u5e76\u6709\u5c11\u91cf\u8102\u6ef4\uff1b\u9759\u6b62\u7684\u8f6f\u9aa8\u7ec6\u80de\u7cd6\u539f\u548c\u8102\u6ef4\u8f83\u591a\uff0c\u5185\u8d28\u7f51(endoplasmic reticulum)\u548c\u9ad8\u5c14\u57fa\u590d\u5408\u4f53\u53d1\u8fbe\u3002SEM\uff0c\u6d45\u5c42\u8f6f\u9aa8\u7ec6\u80de\u5448\u7403\u6837\uff0c\u4f4d\u4e8e\u5706\u5f62\u9677\u7a9d\uff08\u76f4\u5f8411~15\u339b\uff09\u5185\uff0c\u7ec6\u80de\u8868\u9762\u4e3a\u8702\u7a9d\u72b6\uff0c\u7ec6\u80de\u5185\u6709\u8bb8\u591a\u5c0f\u6ce1\u6df1\u5c42\u8f6f\u9aa8\u7ec6\u80de\u9677\u7a9d\u8f83\u5927\uff0c\u957f\u5706\u5f62\uff0c\u7ec6\u80de\u8868\u9762\u4e3a\u8702\u7a9d\u72b6\u3002\u9499\u5316\u533a\u7684\u8f6f\u9aa8\u7ec6\u80de\u4e0d\u89c4\u5219\u6536\u7f29\uff0c\u8868\u9762\u8702\u7a9d\u6837\u7ed3\u6784\u6d88\u5931\uff0c\u7ec6\u80de\u4f53\u79ef\u7f29\u5c0f\u3002TEM\uff0c\u7ec6\u80de\u6709\u77ed\u5c0f\u7a81\u8d77\uff0c\u80de\u8d28\u5185\u6709\u7c97\u9762\u5185\u8d28\u7f51\u3001\u7cd6\u539f\u9897\u7c92\u548c\u4e00\u4e9b\u5fae\u4e1d&nbsp;(microfilaments)\u7b49\u3002\u80de\u5468\u57fa\u8d28\uff08pericellularmatrix\uff0c&nbsp;PCM\uff09\u4e3a\u534a\u900f\u4eae\u73af\u5f62\u5e26\uff0c\u5bbd1~3\u339b\uff0c\u6709\u86cb\u767d\u591a\u7cd6\u9897\u7c92\u548c\u4e0d\u6210\u675f\u7ec6\u4e1d\u3002PCM\u5916\u5468\u539f\u7ea4\u7ef4\u8f83\u7ec6\uff0c\u5bc6\u96c6\u6210\u7f51\uff0c\u5c42\u5c42\u4ea4\u9519\u73af\u7ed5\u8f6f\u9aa8\u7ec6\u80de\u3002\u63a5\u8fd1\u9499\u5316\u533a\u7684\u8f6f\u9aa8\u7ec6\u80de\u5185\u7ec6\u80de\u5668\u51cf\u5c11\uff0cPCM\u900f\u4eae\uff0c\u86cb\u767d\u591a\u7cd6\u9897\u7c92\u5c11\u6216\u65e0\uff0c\u53ef\u89c1\u574f\u6b7b\u7ec6\u80de\u3002\u57fa\u8d28\u4e2d\u6709\u5c11\u91cf\u8102\u8d28\u5c0f\u4f53\uff08Liposomes\uff09\u548c\u57fa\u8d28\u5c0f\u56ca\uff08Matrix vesicles, MVs\uff09\u3002\u8f6f\u9aa8\u7ec6\u80de\u8868\u9762\u8fd8\u6709\u8868\u9762\u9ecf\u8fde\u86cb\u767d\uff08fibronectin\uff09\u7684\u7cd6\u86cb\u767d\uff0c\u7531\u8f6f\u9aa8\u7ec6\u80de\u4ea7\u751f\uff0c\u80fd\u7279\u5f02\u6027\u7ed3\u5408\u2161\u578b\u80f6\u539f\uff1b\u4e0e\u7cd6\u80fa\u591a\u7cd6\uff08glycosaminoglycan\uff09\u7ed3\u5408\u3002\u6c14\u7ba1\u900f\u660e\u8f6f\u9aa8\u7ec6\u80de\u8f6f\u9aa8\u7ec6\u80de\u5206\u6ccc\u80f6\u539f\u539f\u7ea4\u7ef4\u548c\u65e0\u5b9a\u5f62\u57fa\u8d28\u6210\u5206\uff1b\u8868\u9762\u9ecf\u8fde\u86cb\u767d2 \u8f6f\u9aa8\u57fa\u8d28\uff08\u8f6f\u9aa8\u7684\u7ec6\u80de\u95f4\u8d28\uff0c\u7531\u65e0\u5b9a\u5f62\u57fa\u8d28\u548c\u5305\u57cb\u5176\u4e2d\u7684\u7ea4\u7ef4\u7ec4\u6210\u3002\u65e0\u5b9a\u5f62\u57fa\u8d28\u4e3b\u8981\u4e3a\u6c34\uff08\u5927\u91cf\uff09\u86cb\u767d\u591a\u7cd6\uff08\u86cb\u767d\u805a\u7cd6\uff09\uff1b\u86cb\u767d\u8d28\u548c\u7cd6\u86cb\u767d\uff08\u7ea4\u7ef4\u9ecf\u8fde\u86cb\u767d\u3001\u8f6f\u9aa8\u9ecf\u8fde\u86cb\u767d\u7b49\uff09\u7b49\u3002\u591a\u7cd6\u4e3b\u8981\u4e3a\u9178\u6027\u9ecf\u591a\u7cd6\uff08GAG\uff0c\u5305\u62ec\u786b\u9178\u8f6f\u9aa8\u7d20\u3001\u786b\u9178\u4e59\u9170\u809d\u7d20\u3001\u786b\u9178\u89d2\u8d28\u7d20\u3001\u900f\u660e\u8d28\u9178\uff09\u3002\u8fde\u63a5\u900f\u660e\u8d28\u9178\u548c\u86cb\u767d\u591a\u7cd6\u7684\u662f\u8fde\u63a5\u86cb\u767d\u3002\u86cb\u767d\u591a\u7cd6\u805a\u96c6\u4f53\u4e0e\u86cb\u767d\u591a\u7cd6\u5206\u5b50\u7ed3\u5408\u6210\u7f51\uff0c\u6784\u6210\u5206\u5b50\u7b5b\u3002\u5206\u5b50\u7b5b\u4e0e\u900f\u660e\u8f6f\u9aa8\u7684\u2161\u578b\u80f6\u539f\u539f\u7ea4\u7ef4\u652f\u67b6\u7f51\u7ed3\u5408\u5728\u4e00\u8d77\u3002\u90e8\u5206\u6c34\u5206\u5b50\u901a\u8fc7\u6c22\u7ed3\u5408\u5728GAG\u94fe\u7684\u8d1f\u7535\u8377\u57fa\u4e0a\uff1a\u4fdd\u8bc1\u8425\u517b\u7269\u8d28\u968f\u7ec4\u7ec7\u6db2\u6e17\u900f\u901a\u8fc7\u57fa\u8d28\uff0c\u4e3a\u8f6f\u9aa8\u7ec6\u80de\u63d0\u4f9b\u8425\u517b\u5e76\u5e26\u4e0b\u5e26\u8d70\u5176\u4ee3\u8c22\u4ea7\u7269\uff1b\u4fdd\u8bc1\u8f6f\u9aa8\u5177\u6709\u4e00\u5b9a\u5f39\u6027\u8f6f\u9aa8\u56ca\uff08cartilage capsule\uff09\uff1a\u7d27\u9760\u8f6f\u9aa8\u9677\u7a9d\u55dc\u78b1\u6027\u5f3a\uff0c\u5f62\u4f3c\u56ca\u72b6\uff0c\u5305\u56f4\u8f6f\u9aa8\u7ec6\u80de\u3002\u542b\u786b\u9178\u8f6f\u9aa8\u7d20\u8f83\u591a\u76f8\u90bb\u8f6f\u9aa8\u7ec6\u80de\u4e4b\u95f4\u7684\u57fa\u8d28\u7684\u5bbd\u5ea6\u6700\u5927\u8fbe50\u339b\u3002\u57fa\u8d28\u5bf9\u78b1\u6027\u67d3\u6599\u6709\u8f83\u5f3a\u7684\u4eb2\u548c\u529b\uff08\u9ad8\u6d53\u5ea6\u7684\u786b\u9178\u8f6f\u9aa8\u7d20\uff09\u3002\u7d27\u7d27\u56f4\u7ed5\u8f6f\u9aa8\u9677\u7a9d\u7684\u57fa\u8d28\uff08\u8f6f\u9aa8\u56ca\uff09\u539a1~3\u339b\uff0c\u7531\u5f88\u7ec6\u7684\u7ea4\u7ef4\u7f51\u683c\u53ca\u65e0\u5b9a\u5f62\u7269\u8d28\u6784\u6210\u3002\u8f6f\u9aa8\u56ca\u5185\u6709\u5fae\u91cf\u80f6\u539f\u3002\u63a5\u8fd1\u8f6f\u9aa8\u819c\u7684\u57fa\u8d28\uff08\u786b\u9178\u8f6f\u9aa8\u7d20\u5c11\uff0c\u55dc\u9178\u6027\u6210\u5206\u591a\uff09\u5bf9\u4f0a\u7ea2\u3001\u73ab\u7470\u7ea2B\uff08&nbsp;\u7f57\u4e39\u660eB\uff0cRhodamine B\uff09\u3001\u6a58\u9ec4G\uff08orange G\uff09\u7b49\u9178\u6027\u67d3\u6599\u6709\u4eb2\u548c\u529b\uff1b\u4f4d\u4e8e\u8f6f\u9aa8\u6df1\u90e8\u7684\u57fa\u8d28\uff08\u786b\u9178\u8f6f\u9aa8\u7d20\u7b49\u55dc\u78b1\u6027\u7269\u8d28\u591a\uff09\u5bf9\u78b1\u6027\u67d3\u6599\u6709\u4eb2\u548c\u529b\u3002\u7ea4\u7ef4\u5305\u57cb\u4e8e\u57fa\u8d28\u4e2d\uff0c\u4f7f\u8f6f\u9aa8\u5185\u6709\u97e7\u6027\u6216\u5f39\u6027\u2161\u578b\u80f6\u539f\u7ec4\u6210\u80f6\u539f\u539f\u7ea4\u7ef43 \u8f6f\u9aa8\u5c0f\u7ba1\u67d0\u4e9b\u52a8\u7269\u7684\u591a\u5904\u8f6f\u9aa8\u6709\u7ec6\u5c0f\u7684\u5206\u652f\u5c0f\u7ba1\u79f0\u8f6f\u9aa8\u5c0f\u7ba1\u3002\u5c0f\u7ba1\u5185\u6709\u7ed3\u7f14\u7ec4\u7ec7\u548c\u8840\u7ba1\uff0c\u6e90\u4e8e\u8f6f\u9aa8\u819c\u3002\u76f8\u90bb\u7684\u8f6f\u9aa8\u5c0f\u7ba1\u53ca\u5176\u5206\u652f\u4e4b\u95f4\u65e0\u543b\u5408\u3002\u65b0\u751f\u513f\u7b2c4~6\u808b\u8f6f\u9aa8\u6700\u5148\u51fa\u73b0\u8840\u7ba1\uff0c\u968f\u5e74\u9f84\u589e\u957f\uff0c\u808b\u8f6f\u9aa8\u7684\u8840\u7ba1\u9762\u79ef\u6709\u6240\u589e\u5927\uff08\u4e8c\uff09\u5f39\u6027\u8f6f\u9aa8\u5206\u5e03\u4e8e\u8033\u90ed(auricle)\u3001\u5916\u8033\u9053\uff08External Acoustic Meatus\uff09\u3001\u54bd\u9f13\u7ba1\uff08otopharyngeal tubes\uff09\u3001\u4f1a\u538c\uff08epiglottis\uff09\u4ee5\u53ca\u5589\uff08\u5982\u5c0f\u89d2\u8f6f\u9aa8corniculate cartilage\u3001\u6954\u72b6\u8f6f\u9aa8cuneiform cartilages\u548c\u6753\u72b6\u8f6f\u9aa8arytenoid cartilage\u7684\u5c16\u7aef\uff09\uff0c\u6709\u660e\u663e\u7684\u53ef\u5f2f\u66f2\u6027\u548c\u5f39\u6027\u65b0\u9c9c\u65f6\u5448\u4e0d\u900f\u660e\u7684\u9ec4\u8272\u7ec4\u6210\u6210\u5206\u548c\u7ed3\u6784\u5f62\u5f0f\u4e0e\u900f\u660e\u8f6f\u9aa8\u76f8\u4f3c\uff0c\u4ee5\u5f39\u6027\u7ea4\u7ef4\u4e3a\u4e3b\uff0c\u80f6\u539f\u539f\u7ea4\u7ef4\u8f83\u5c11\u3002\u5f39\u6027\u7ea4\u7ef4\u6709\u5206\u652f\uff0c\u4ea4\u7ec7\u6392\u5217\u3002\u8f6f\u9aa8\u4e2d\u5fc3\u7684\u5f39\u6027\u7ea4\u7ef4\u6392\u5217\u5bc6\u96c6\uff0c\u8f6f\u9aa8\u819c\u4e0b\u7684\u5f39\u6027\u7ea4\u7ef4\u6392\u5217\u758f\u677e\uff0c\u5e76\u4e0e\u8f6f\u9aa8\u819c\u7684\u5f39\u6027\u7ea4\u7ef4\u76f8\u5ef6\u7eed\u3002\u4eba\u8033\u58f3\u5f39\u6027\u8f6f\u9aa8\u8f6f\u9aa8\u7ec6\u80de\u5448\u7403\u5f62\uff0c\u5355\u4e2a\u6216\u4ee5\u540c\u6e90\u7ec6\u80de\u7fa4\u65b9\u5f0f\u5206\u5e03\u3002\u540c\u6e90\u7ec6\u80de\u7fa4\u6570\u91cf\u5927\uff0c2~4\u4e2a\u8f6f\u9aa8\u7ec6\u80de\u8f6f\u9aa8\u7ec6\u80de\u4ea7\u751f\u5f39\u6027\u8f6f\u9aa8\u7684\u5f39\u6027\u7ea4\u7ef4\u548c\u80f6\u539f\u539f\u7ea4\u7ef4\u57fa\u8d28\u8f83\u5c11&nbsp;\uff08\u4e09\uff09\u7ea4\u7ef4\u8f6f\u9aa8\u7ea4\u7ef4\u8f6f\u9aa8&nbsp; 1\u8f6f\u9aa8\u7ec6\u80de2\u8f6f\u9aa8\u56ca3\u8f6f\u9aa8\u7ec6\u80de\u94fe4\u8f6f\u9aa8\u57fa\u8d28\u4e3b\u8981\u89c1\u4e8e\u690e\u95f4\u76d8\uff08intervertebral disc\uff09\u3001\u7ea4\u7ef4\u73af\uff08&nbsp;Annulus\uff09\u3001\u5173\u8282\u76d8\uff08Articular disc\uff09\u548c\u534a\u6708\u677f\u7684\u4e00\u90e8\u5206\uff0c\u4e5f\u89c1\u4e8e\u80a1\u9aa8\u5934\u97e7\u5e26\uff08ligament of the head of the femur\uff09\u3001\u803b\u9aa8\u8054\u5408(pubic symphysis)\u4ee5\u53ca\u67d0\u4e9b\u808c\u8171\uff08tendon\uff09\u548c\u97e7\u5e26\uff08ligament\uff09\u9644\u7740\u4e8e\u9aa8\u7684\u90e8\u4f4d\u7b49\u4eba\u690e\u95f4\u76d8\u7ea4\u7ef4\u8f6f\u9aa8\u7ec6\u80de\u95f4\u8d28\u5185\u6709\u788d\u5e73\u884c\u6216\u4ea4\u53c9\u6392\u5217\u7684\u80f6\u539f\u7ea4\u7ef4\u675f\uff08\u2160\u578b\u80f6\u539f\u86cb\u767d\uff09\uff0c\u65b0\u9c9c\u65f6\u5448\u4e0d\u900f\u660e\u7684\u4e73\u767d\u8272\uff0c\u6709\u4e00\u5b9a\u4f38\u5c55\u6027\u67d0\u4e9b\u90e8\u4f4d\u7684\u7ea4\u7ef4\u8f6f\u9aa8\u4e2d\u6709\u5c11\u91cf\u5f39\u6027\u7ea4\u7ef4\u6210\u5206\u8f6f\u9aa8\u7ec6\u80de\u5206\u5e03\u4e8e\u7ea4\u7ef4\u675f\u4e4b\u95f4\uff0c\u5355\u72ec\u6216\u6210\u5bf9\u5b58\u5728\uff0c\u6216\u6392\u5217\u6210\u5355\u884c\u3002\u8f6f\u9aa8\u7ec6\u80de\u5375\u5706\u5f62\u6216\u6241\u5e73\u5f62\u3002\u8f6f\u9aa8\u9677\u7a9d\u5468\u56f4\u6709\u8f6f\u9aa8\u56ca\u7ea4\u7ef4\u675f\u4e4b\u95f4\u65e0\u5b9a\u5f62\u57fa\u8d28\u6210\u5206\u5f88\u5c11\uff08\u56db\uff09\u8f6f\u9aa8\u7684\u8001\u5316\uff08\u9499\u5316\uff09\u548c\u518d\u751f1 \u8f6f\u9aa8\u7684\u8001\u5316\uff08\u9499\u5316\uff09\u901a\u5e38\u53d1\u751f\u5728\u8f6f\u9aa8\u5185\u6210\u9aa8\u7684\u6210\u9aa8\u533a\uff0c\u5176\u8f6f\u9aa8\u7ec6\u80de\u5185\u7ec6\u80de\u5668\u660e\u663e\u51cf\u5c11\uff0c\u5916\u5f62\u5448\u4e0d\u89c4\u5219\u76b1\u7f29\u3002&nbsp;\u5728\u5c06\u8981\u9499\u5316\u7684\u90e8\u4f4d\uff0c\u5176\u8f6f\u9aa8\u57fa\u8d28\u5185\u51fa\u73b0\u6709\u819c\u5305\u88f9\u7684\u5c0f\u6ce1\u79f0\u57fa\u8d28\u5c0f\u6ce1\uff08matrixvesicle\uff09\u3002\u5c0f\u6ce1\u5185\u6709\u67d0\u4e9b\u80de\u8d28\u6210\u5206\uff0c\u5e76\u6709\u9178\u6027\u78f7\u9178\u9176\uff08acid phosphatase\uff0cACP\uff09\u548cATP\u9176\uff08\u817a\u82f7\u4e09\u78f7\u9178\u9176\uff0cadenosine triphosphatase\uff09\u6d3b\u6027\u3002\u9aba\u677f\uff08growth plate,epiphysical\uff09\u7684\u5404\u90e8\u5206\u6709\u57fa\u8d28\u5c0f\u6ce1\uff0c\u4f46\u8f6f\u9aa8\u7ec6\u80de\u80a5\u5927\u533a\u6700\u591a\u3002\u9499\u5316\u65e9\u671f\uff0c\u57fa\u8d28\u5c0f\u6ce1\u5185\u90e8\u548c\u8868\u9762\u6709\u7ec6\u5c0f\u7684\u7f9f\u57fa\u78f7\u7070\u77f3\uff08hydroxylapatite\uff0cHAP\uff09\u7ed3\u6676\u3002\u7f9f\u57fa\u78f7\u7070\u77f3\u7ed3\u6676\u6269\u5927\u5e76\u5408\u5e76\uff0c\u8f6f\u9aa8\u53d8\u5f97\u4e0d\u900f\u660e\u3001\u786c\u5ea6\u589e\u52a0\u548c\u8106\u6027\u589e\u5927\u3002\u8f6f\u9aa8\u7ec6\u80de\u80a5\u5927\u533a\u53c8\u79f0\u4e34\u65f6\u9499\u5316\u533a\u3002\u4eba\u5589\u90e8\u7684\u9499\u5316\u53d1\u751f\u572820\u5c81\u4f1a\u538c\u8f6f\u9aa8\u5185\u6709\u57fa\u8d28\u5c0f\u6ce1\uff0c\u4f46\u4e0d\u542b\u9178\u6027\u78f7\u9178\u9176\u3001\u78b1\u6027\u78f7\u9178\u9176\uff08alkaline phosphatase\uff0cALK\u3001AKP\uff09\u548cATP\u9176\u30022 \u8f6f\u9aa8\u7684\u518d\u751f\u8f6f\u9aa8\u6709\u4e00\u5b9a\u518d\u751f\u80fd\u529b\u8f6f\u9aa8\u53d7\u4f24\u540e\uff0c\u8f6f\u9aa8\u7ec6\u80de\u4fdd\u5b58\u5b8c\u597d\uff0c\u8f6f\u9aa8\u57fa\u8d28\u8fc5\u901f\u518d\u5f62\u6210\u4f46\u518d\u751f\u80fd\u529b\u6bd4\u9aa8\u7ec4\u7ec7\u5f31\u3002\u8f6f\u9aa8\u635f\u4f24\u6216\u88ab\u5207\u9664\u4e00\u90e8\u5206\u540e\uff0c\u672a\u89c1\u6709\u76f4\u63a5\u7684\u8f6f\u9aa8\u518d\u751f\uff0c\u5728\u635f\u4f24\u5904\u5148\u51fa\u73b0\u7ec4\u7ec7\u574f\u6b7b\u548c\u840e\u7f29\uff0c\u968f\u540e\u7531\u8f6f\u9aa8\u819c\u6216\u90bb\u8fd1\u7b4b\u819c\u6240\u4ea7\u751f\u7684\u7ed3\u7f14\u7ec4\u7ec7\u586b\u5145\u3002\u8fd9\u79cd\u8089\u82bd\u7ec4\u7ec7\u4e2d\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u8f6c\u53d8\u4e3a\u6210\u8f6f\u9aa8\u7ec6\u80de\uff0c\u6210\u8f6f\u9aa8\u7ec6\u80de\u8fdb\u4e00\u6b65\u5206\u5316\u4e3a\u8f6f\u9aa8\u7ec6\u80de\uff0c\u4ea7\u751f\u65b0\u7684\u57fa\u8d28\uff0c\u5f62\u6210\u65b0\u7684\u8f6f\u9aa8\u3002\u6210\u5e74\u54fa\u4e73\u52a8\u7269\u8f6f\u9aa8\u635f\u4f24\u540e\u7684\u4fee\u590d\u4e3b\u8981\u4e3a\u7ed3\u7f14\u7ec4\u7ec7\u5316\u751f\u3002\uff08\u4e94\uff09\u8f6f\u9aa8\u819c\uff08perichondrium\uff09\u8f6f\u9aa8\u5468\u56f4\u88ab\u8986\u7684\u8584\u5c42\u81f4\u5bc6\u7ed3\u7f14\u7ec4\u7ec7\u5173\u8282\u8f6f\u9aa8\u65e0\u8f6f\u9aa8\u819c\u7ea4\u7ef4\u8f6f\u9aa8\u65e0\u8f6f\u9aa8\u819c\u8f6f\u9aa8\u819c\u5206\u4e24\u5c42\uff1a\u5916\u5c42\u7ea4\u7ef4\u591a\uff0c\u4e0e\u8f6f\u9aa8\u819c\u5916\u7684\u7ed3\u7f14\u7ec4\u7ec7\u76f8\u8fde\uff1b\u5185\u5c42\u7ec6\u80de\u591a\uff0c\u6709\u8bb8\u591a\u68ad\u5f62\u7684\u9aa8\u7956\u7ec6\u80de\uff0c\u53ef\u5206\u5316\u4e3a\u6210\u8f6f\u9aa8\u7ec6\u80de\uff0c\u6210\u8f6f\u9aa8\u7ec6\u80de\u518d\u5206\u5316\u4e3a\u8f6f\u9aa8\u819c\uff1b\u8fd8\u6709\u8840\u7ba1\u3001\u6dcb\u5df4\u7ba1\u548c\u795e\u7ecf\u8f6f\u9aa8\u819c\u6709\u5f88\u5f3a\u7684\u518d\u751f\u80fd\u529b\u4e8c\u3001\u9aa8\u9aa8\uff08\u9aa8\u9abc\u7cfb\u7edf\u4e3b\u8981\u5668\u5b98\uff09\u7531\u9aa8\u7ec4\u7ec7\u548c\u9aa8\u819c\u7ec4\u6210\u9aa8\u6709\u5e74\u9f84\u6027\u53d8\u5316\uff0c\u7ec8\u8eab\u53d7\u627f\u53d7\u7684\u538b\u529b\u800c\u66f4\u65b0\u548c\u6539\u5efa\u5177\u6709\u521b\u4f24\u6108\u5408\u3001\u4fee\u590d\u518d\u751f\u548c\u79fb\u690d\u5b58\u6d3b\u7684\u80fd\u529b\uff1b\u953b\u70bc\u80fd\u4fc3\u8fdb\u9aa8\u53d1\u80b2\uff1b\u652f\u6301\u673a\u4f53\u7684\u8f6f\u7ec4\u7ec7\uff0c\u652f\u6491\u4f53\u91cd\uff1b\u6760\u6746\u4f5c\u7528\uff0c\u4f7f\u9aa8\u9abc\u808c\u6536\u7f29\u589e\u5927\uff0c\u8f6c\u5316\u4e3a\u8eab\u4f53\u8fd0\u52a8\uff1b\u4fdd\u6301\u5668\u5b98\uff0c\u5982\u9885\u8154\u3001\u690e\u7ba1\u3001\u80f8\u8154\u3001\u8179\u8154\u3001\u9aa8\u76c6\u8154\uff1b\u9499\u78f7\u548c\u5176\u4ed6\u79bb\u5b50\u8d2e\u5b58\uff08\u4e00\uff09\u9aa8\u7ec4\u7ec7\u7531\u7ec6\u80de\u548c\u77ff\u5316\u7684\u7ec6\u80de\u95f4\u8d28\uff08\u9aa8\u57fa\u8d28\uff09\u7ec4\u6210\u7279\u70b9\uff1a\u7ec6\u80de\u95f4\u8d28\u4eba\u6709\u5927\u91cf\u9aa8\u76d0\u6c89\u79ef\uff08\u7ec6\u80de\u95f4\u8d28\u77ff\u5316\uff09\uff0c\u4e3a\u4eba\u4f53\u6700\u575a\u786c\u7684\u7ec4\u7ec7\u4e4b\u4e00\u4eba\u6241\u9aa8\u8131\u9499 \u786b\u5807\u67d3\u82721 \u9aa8\u7684\u7ec6\u80de\u9aa8\u7ec6\u80de\u4f4d\u4e8e\u9aa8\u7ec4\u7ec7\u5185\uff0c\u9aa8\u7956\u7ec6\u80de\u3001\u6210\u9aa8\u7ec6\u80de\u3001\u6210\u9aa8\u7ec6\u80de\u5206\u5e03\u5728\u9aa8\u7ec4\u7ec7\u8868\u9762\u6216\u9644\u8fd1\uff081\uff09\u9aa8\u7956\u7ec6\u80de\uff08\u9aa8\u539f\u7ec6\u80de\uff0costeogenic cell\uff09\u80de\u4f53\u5c0f\uff0c\u4e0d\u89c4\u5219\u68ad\u5f62\uff0c\u7a81\u8d77\u5f88\u7ec6\u5c0f\u3002\u80de\u4f53\u5185\u6709\u4e00\u4e2a\u692d\u5706\u5f62\u6216\u7ec6\u957f\u5f62\u7684\u6838\uff0c\u67d3\u8272\u8d28\u9897\u7c92\u7ec6\u800c\u5206\u6563\uff0c\u6838\u7740\u8272\u6d45\u3002\u80de\u8d28\u5c11\uff0c\u55dc\u9178\u6027\u6216\u5f31\u55dc\u78b1\u6027\uff0c\u7ec6\u80de\u5668\u5f88\u5c11\uff0c\u4ec5\u6709\u5c11\u91cf\u6838\u7cd6\u4f53\u548c\u7ebf\u7c92\u4f53\u80fd\u5206\u5316\u4e3a\u6210\u9aa8\u7ec6\u80de\u3001\u6210\u8f6f\u9aa8\u7ec6\u80de\u6216\u6210\u7ea4\u7ef4\u7ec6\u80de\u3002\u9aa8\u7956\u7ec6\u80de\u4e24\u7c7b\uff1a\u2460\u51b3\u5b9a\u6027\u9aa8\u7956\u7ec6\u80de\uff08DOPC\uff09\u4f4d\u4e8e\u6216\u9760\u8fd1\u9aa8\u7684\u6e38\u79bb\u9762\u4e0a\uff0c\u5982\u9aa8\u5185\u819c\u548c\u9aa8\u5916\u819c\u5185\u5c42\u3001\u751f\u957f\u9aa8\u9aba\u677f\u7684\u9499\u5316\u8f6f\u9aa8\u5c0f\u6881\u4e0a\u548c\u9aa8\u9ad3\u57fa\u8d28\u5185\u3002\u5728\u9aa8\u751f\u957f\u671f\u548c\u5185\u5185\u90e8\u6539\u5efa\u6216\u9aa8\u6298\u4fee\u590d\uff0c\u4ee5\u53ca\u5176\u4ed6\u5f62\u5f0f\u635f\u4f24\u4fee\u590d\u65f6\uff0c\u5f88\u6d3b\u8dc3\uff0c\u7ec6\u80de\u5206\u88c2\u5e76\u5206\u5316\u4e3a\u6210\u9aa8\u7ec6\u80de\u2461\u5df2\u8bf1\u5bfc\u6027\u9aa8\u7956\u7ec6\u80de\uff08IOPC\uff09\u5b58\u5728\u4e8e\u9aa8\u9abc\u7cfb\u7edf\u548c\u7ed3\u7f14\u7ec4\u7ec7\u5185\u3002\u4e0d\u80fd\u81ea\u53d1\u5f62\u6210\u9aa8\u7ec4\u7ec7\uff0c\u7ecf\u9002\u5b9c\u523a\u6fc0\u5982\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d\uff08BMP\uff09\u6216\u6ccc\u5c3f\u9053\u79fb\u884c\u4e0a\u76ae\u7ec6\u80de\u8bf1\u5bfc\u7269\u4f24\u5f62\u6210\u6210\u9aa8\u7ec4\u7ec7\u3002\u4f4d\u4e8e\u9aa8\u9abc\u7cfb\u7edf\u548c\u7ed3\u7f14\u7ec4\u7ec7\u9aa8\u7956\u7ec6\u80deBM\u9aa8\u57fa\u8d281\u9aa8\u9677\u7a9dC\u9aa8\u5c0f\u7ba1OB\u9aa8\u7ec6\u80de\u80de\u4f53N\u7ec6\u80de\u6838P\u9aa8\u7ec6\u80de\u7a81\u8d77\uff082\uff09\u6210\u9aa8\u7ec6\u80de\uff08\u9aa8\u6bcd\u7ec6\u80de\uff0costeoblast\uff09\u4e3b\u8981\u6765\u6e90\u4e8e\u9aa8\u7956\u7ec6\u80de\u88ab\u8986\u4e8e\u9aa8\u7ec4\u7ec7\u8868\u9762\u6d3b\u8dc3\u7684\u6210\u9aa8\u7ec6\u80de\u80de\u4f53\u5448\u7acb\u65b9\u5f62\u6216\u77ee\u67f1\u72b6\uff0c\u50cf\u5355\u5c42\u4e0a\u76ae\u6837\u6392\u5217\uff0c\u5e76\u501f\u7ec6\u77ed\u7684\u7a81\u8d77\u76f8\u8fde\u3002\u7ec6\u80de\u9ad850~80\u339b\uff0c\u6838\u5927\u800c\u5706\uff0c\u4f4d\u4e8e\u7ec6\u80de\u8fdc\u79bb\u9aa8\u8868\u9762\u7684\u4e00\u7aef\uff0c\u6838\u4ec1\u6e05\u6670\u3002\u80de\u8d28\u55dc\u78b1\u6027\u5f3a\uff0c\u9ad8\u5c14\u57fa\u590d\u5408\u4f53\u53d1\u8fbe\uff0c\u4f4d\u4e8e\u80de\u6838\u4e0e\u7ec6\u80de\u57fa\u90e8\u4e4b\u95f4\u7684\u6d45\u67d3\u533a\u3002\u7ebf\u7c92\u4f53\u4e30\u5bcc\uff0c\u5927\u591a\u5448\u7ec6\u957f\u5f62\u3002\u80de\u8d28\u5448\u78b1\u6027\u78f7\u9178\u9176\u5f3a\u9633\u6027\uff0c\u53ef\u89c1\u8bb8\u591aPAS\u9633\u6027\u9897\u7c92\u3002\u65b0\u9aa8\u505c\u6b62\u540e\uff0cPAS\u9897\u7c92\u6d88\u5931\uff0c\u80de\u8d28\u78b1\u6027\u78f7\u9178\u9176\u6d3b\u6027\u5f31\uff0c\u6210\u9aa8\u7ec6\u80de\u4e3a\u6241\u5e73\u72b6\uff0c\u88ab\u8986\u4e8e\u9aa8\u7ec4\u7ec7\u8868\u9762\u5747\u8d85\u5fae\u7ed3\u6784\u4f3c\u6210\u7ea4\u7ef4\u7ec6\u80de\u3002\u5728\u9aa8\u5f62\u6210\u975e\u5e38\u6d3b\u8dc3\u5904\uff0c\u5982\u9aa8\u6298\u3001\u9aa8\u75c2\u53ca\u80bf\u7624\u6216\u611f\u67d3\u5f15\u8d77\u7684\u957f\u9aa8\u4e2d\uff0c\u6210\u9aa8\u7ec6\u80de\u5f62\u6210\u590d\u5c42\uff0c\u5806\u79ef\u5728\u9aa8\u7ec4\u7ec7\u8868\u9762\u3002\u7535\u955c\u4e0b\u5927\u91cf\u7c97\u9762\u5185\u8d28\u7f51\u3001\u4e30\u5bcc\u6e38\u79bb\u6838\u7cd6\u4f53\uff08free ribosomes\uff09\u548c\u53d1\u8fbe\u9ad8\u5c14\u57fa\u590d\u5408\u4f53\u3002\u7c97\u9762\u5185\u8d28\u7f51\u5206\u5e03\u4e8e\u80de\u8d28\u5404\u5904\uff1b\u5927\u7684\u9ad8\u5c14\u57fa\u590d\u5408\u4f53\u4e0a\u8fde\u6709\u8bb8\u591a\u5c0f\u7a7a\u6ce1\uff1b\u7ebf\u7c92\u4f53\u8f83\u591a\uff0c\u5185\u6709\u76f4\u5f8455nm\u7684\u81f4\u5bc6\u9897\u7c92\uff08Dense granules\uff09\u5373\u78b3\u9178\u77fd\uff08Silica Carbonnate\uff09\u9897\u7c92\uff1b\u6eb6\u9176\u4f53\uff08lysosomes\uff09\u8f83\u591a\uff1b\u8102\u6ef4\u5076\u89c1\uff1b\u4e00\u4e9b\u76f8\u5f53\u5927\u7684\u56ca\u6ce1\uff08Vesicles\uff09\u5185\u542b\u4e00\u5b9a\u5bc6\u5ea6\u7684\u65e0\u5b9a\u5f62\u7269\u8d28\u6216\u4e1b\u6bdb\u72b6\u7269\uff08PAS\u9633\u6027\u9897\u7c92\uff09\uff1b\u8f83\u591a\u7684\u4e2d\u95f4\u4e1d\uff08intermediate filament\uff0cIF\uff09\uff1b\u4e00\u4e9b\u5fae\u7ba1\uff08microtubules\uff09\u3002\u76f8\u90bb\u6210\u9aa8\u7ec6\u80de\u7a81\u8d77\u4e4b\u95f4\u53ca\u4e0e\u9aa8\u7ec6\u80de\u7a81\u8d77\u4e4b\u95f4\u6709\u7f1d\u9699\u8fde\u63a5\uff08gap junction\uff09\u3002\u6210\u9aa8\u7ec6\u80de\u8868\u9762\u6709\u7532\u72b6\u65c1\u817a\u6fc0\u7d20\uff08parathyroid hormone\uff09\u53d7\u4f53\u3001\u96cc\u6fc0\u7d20\uff08Estrogen\uff09\u53d7\u4f53\u3001\u767d\u7ec6\u80de\u4ecb\u7d20-1\uff08Interleukin-1\uff0cIL-1\uff09\u53d7\u4f53\u3001\u767d\u7ec6\u80de\u6291\u5236\u56e0\u5b50\uff08&nbsp;Inhibitory factor\uff0cLIF\uff09\u548c\u6574\u5408\u7d20\uff08\u6574\u8054\u86cb\u767d\uff0cIntegrin \uff09\u7b49\u80ce\u513f\u6210\u9aa8\u7ec6\u80de\uff08Bar=2\u339b\uff09\u5408\u6210\u548c\u5206\u6ccc\u9aa8\u57fa\u8d28\u4e2d\u7684\u591a\u79cd\u6709\u673a\u6210\u5206\uff1a\u2160\u578b\u80f6\u539f\u86cb\u767d\u3001\u86cb\u767d\u591a\u7cd6\u3001\u9aa8\u9499\u86cb\u767d\u3001\u9aa8\u9ecf\u8fde\u86cb\u767d&nbsp;(Osteonectin)&nbsp;\u3001\u9aa8\u6865\u86cb\u767d\uff08osteopotin\uff0c OPN)\u3001\u9aa8\u553e\u6db2\u9178\u86cb\u767d\uff08Bone sialoprotein\uff0cBSP\uff09\u3001\u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b50\u2160\uff08IGF-1\uff09\u3001\u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b50\u2161\uff08IGF-2\uff09\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08Fibroblast Growth Factors\uff0cFGFs\uff09\u3001\u767d\u7ec6\u80de\u4ecb\u7d20\u2160\uff08Interleukin-1\uff0cIL-1\uff09\u3001\u524d\u5217\u817a\u7d20\uff08prostaglandin\uff0cPG\uff09\u7b49\u53ca\u7834\u9aa8\u7ec6\u80de\u523a\u6fc0\u56e0\u5b50\u3001\u524d\u80f6\u539f\u9176\u3001\u80de\u8d28\u7d20\u539f\u6fc0\u6d3b\u5242\u6210\u9aa8\u7ec6\u80de\u4e3b\u8981\u529f\u80fd\uff1a\u4ea7\u751f\u80f6\u539f\u7ea4\u7ef4\u548c\u65e0\u5b9a\u5f62\u57fa\u8d28\uff0c\u5373\u5f62\u6210\u7c7b\u9aa8\u8d28\uff1b\u5206\u6ccc\u9aa8\u9499\u86cb\u767d\u3001\u9aa8\u9ecf\u8fde\u86cb\u767d\u548c\u9aa8\u553e\u6db2\u9178\u86cb\u767d\u7b49\u975e\u80f6\u539f\u86cb\u767d\uff0c\u4fc3\u8fdb\u9aa8\u7ec4\u7ec7\u77ff\u5316\uff1b\u8c03\u8282\u9aa8\u7ec4\u7ec7\u5f62\u6210\u548c\u5438\u6536\uff08\u7ec6\u80de\u8868\u9762\u6709\u591a\u79cd\u9aa8\u5438\u6536\u523a\u6fc0\u56e0\u5b50\u7684\u53d7\u4f53\uff09\uff083\uff09\u9aa8\u7ec6\u80de\uff08Osteocyte \uff09\u591a\u7a81\u7ec6\u80de\uff0c\u7a81\u8d77\u4f4d\u4e8e\u9aa8\u57fa\u8d28\uff08bone matrix\uff09\u5185\uff0c\u80de\u4f53\u4f4d\u4e8e\u9aa8\u9677\u7a9d\uff08\u7ec6\u80de\u7684\u8154\u9699\uff09\u5185\u3002\u6bcf\u4e2a\u9aa8\u9677\u7a9d\uff08bone lacuna\u5185\u4ec5\u6709\u4e00\u4e2a\u7ec6\u80de\u80de\u4f53\u3002\u4ece\u9aa8\u9690\u7a9d\u5411\u56db\u5468\u4f38\u51fa\u9aa8\u5c0f\u7ba1\uff08bone canaliculi\uff09\uff0c\u9aa8\u7ec6\u80de\u7a81\u8d77\u9aa8\u9677\u7a9d\u4e2d\u3002\u6700\u5e74\u8f7b\u7684\u9aa8\u7ec6\u80de\u4f4d\u4e8e\u7c7b\u9aa8\u8d28\u4e2d\uff0c\u5f62\u6001\u7ed3\u6784\u4e0e\u6210\u9aa8\u7ec6\u80de\u76f8\u4f3c\u3002\u80de\u4f53\u4e3a\u6241\u692d\u5706\u5f62\uff0c\u4f4d\u4e8e\u6bd4\u80de\u4f53\u5927\u8bb8\u591a\u7684\u5706\u5f62\u9aa8\u9677\u7a9d\u5185\u3002\u7a81\u8d77\u591a\u800c\u7ec6\uff0c\u5404\u81ea\u4f4d\u4e8e\u4e00\u4e2a\u9aa8\u5c0f\u7ba1\u4e2d\uff0c\u6709\u7684\u7a81\u8d77\u6709\u5c11\u8bb8\u5206\u652f\u3002\u6838\u5375\u5706\u5f62\uff0c\u4f4d\u4e8e\u80de\u4f53\u4e00\u7aef\uff0c\u6838\u5185\u6709\u4e00\u4e2a\u6838\u4ec1\uff0c\u67d3\u8272\u8d28\u8d34\u9644\u5728\u6838\u819c\u3002HE\u67d3\u8272\uff0c\u80de\u8d28\u55dc\u78b1\u6027\uff0c\u8fd1\u6838\u5904\u6709\u4e00\u6d45\u67d3\u533a\u3002\u80de\u8d28\u5448\u78b1\u6027\u78f7\u9178\u9176\u9633\u6027\uff0c\u8fd8\u6709PAS\u9633\u6027\u9897\u7c92\u3002\u7535\u955c\u4e0b\uff0c\u7c97\u9762\u5185\u8d28\u7f51\u5e7f\u6cdb\u5206\u5e03\uff0c\u6e38\u79bb\u6838\u7cd6\u4f53\u6563\u5728\uff0c\u7ebf\u7c92\u4f53\u4e2d\u7b49\u91cf\uff0c\u9ad8\u5c14\u57fa\u590d\u5408\u4f53\u53d1\u8fbe\uff0c\u5206\u6563\u5b58\u5728\u5927\u578b\u56ca\u6ce1\u3002\u4ea7\u751f\u7ec6\u80de\u95f4\u8d28\uff08\u6709\u673a\u8d28\uff09\u3002\u8f83\u6210\u719f\u7684\u9aa8\u7ec6\u80de\u4f4d\u4e8e\u77ff\u5316\u7684\u9aa8\u8d28\u6d45\u90e8\uff0c\u80de\u4f53\u5448\u53cc\u51f8\u6241\u692d\u5706\u5f62\uff0c\u4f53\u79ef\u5c0f\u4e8e\u5e74\u5e7c\u7684\u9aa8\u7ec6\u80de\u3002\u6838\u8f83\u5927\uff0c\u692d\u5706\u5f62\uff0c\u5c45\u80de\u4f53\u4e2d\u592e\uff0cHE\u67d3\u8272\u7740\u8272\u8f83\u6df1\uff0c\u53ef\u89c1\u6838\u4ec1\u3002\u80de\u8d28\u76f8\u5bf9\u5c11\uff0cHE\u67d3\u8272\u5f31\u55dc\u78b1\u6027\uff0c\u7532\u82ef\u80fa\u84dd\u67d3\u8272\u5f88\u6d45\u3002\u7535\u955c\u4e0b\uff0c\u7c97\u9762\u5185\u8d28\u7f51\u5c11\uff0c\u9ad8\u5c14\u57fa\u590d\u5408\u4f53\u5c0f\uff0c\u7ebf\u7c92\u4f53\u5c11\u91cf\u5206\u6563\u5b58\u5728\uff0c\u6e38\u79bb\u6838\u7cd6\u4f53\u5c11\u6210\u719f\u7684\u9aa8\u7ec6\u80de\u4f4d\u4e8e\u9aa8\u8d28\u6df1\u90e8\uff0c\u80de\u4f53\u6bd4\u539f\u6765\u7684\u6210\u9aa8\u7ec6\u80de\u5c0f\uff0870%\uff09\uff0c\u6838\u8d28\u6bd4\u589e\u5927\uff0c\u80de\u8d28\u6613\u88ab\u7532\u82ef\u80fa\u84dd\u67d3\u8272\u3002\u7535\u955c\u4e0b\uff0c\u7c97\u9762\u5185\u8d28\u7f51\u548c\u9ad8\u5c14\u57fa\u590d\u5408\u4f53\u4e00\u5b9a\u91cf\uff0c\u7ebf\u7c92\u4f53\u591a\uff0c\u53ef\u89c1\u6eb6\u9176\u4f53\u3002\u7ebf\u7c92\u4f53\u4e2d\u6709\u7535\u5b50\u81f4\u5bc6\u9897\u7c92\uff0c\u4e0e\u7834\u9aa8\u7ec6\u80de\u76f8\u4f3c\u3002\u5f62\u6210\u8f83\u957f\u7a81\u8d77\uff0c\u76f4\u5f8485~100 nm\uff08\u9aa8\u5c0f\u7ba11\/2~1\/4\uff09\u3002\u76f8\u90bb\u9aa8\u7ec6\u80de\u7684\u7a81\u8d77\u7aef\u5bf9\u7aef\u5730\u76f8\u8fde\uff0c\u6216\u4ee5\u67d0\u672b\u7aef\u4fa7\u5bf9\u4fa7\u76f8\u8d34\uff0c\u5176\u95f4\u6709\u7f1d\u9699\u8fde\u63a5\u3002\u6210\u719f\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u4f4d\u4e8e\u9aa8\u9677\u7a9d\u548c\u9aa8\u5c0f\u7ba1\u7684\u7f51\u72b6\u901a\u9053\u5185\u3002\u9aa8\u7ec6\u80de\u7684\u6700\u5927\u7279\u5f81\u662f\u7ec6\u80de\u7a81\u8d77\u5728\u9aa8\u5c0f\u7ba1\u5185\u4f38\u5c55\uff0c\u4e0e\u76f8\u90bb\u7684\u9aa8\u7ec6\u80de\u8fde\u63a5\uff0c\u6df1\u90e8\u7684\u9aa8\u7ec6\u80de\u4e0e\u90bb\u8fd1\u9aa8\u8868\u9762\u7684\u9aa8\u7ec6\u80de\u7a81\u8d77\u548c\u9aa8\u5c0f\u7ba1\u8fde\u63a5\u3002\u9aa8\u7ec6\u80de\u7684\u529f\u80fd\uff1a\u9aa8\u7ec6\u80de\u6027\u6eb6\u9aa8\u548c\u9aa8\u7ec6\u80de\u6027\u6210\u9aa8\uff1a\u7532\u72b6\u65c1\u817a\u6fc0\u7d20\uff08PGH\uff09\u3002\u964d\u9499\u7d20\uff08CT\uff09\uff0c1,25-\u4e8c\u7f9f\u7ef4\u751f\u7d20D3[1\uff0c25-\uff08OH\uff092D3]\uff1b\u53c2\u4e0e\u8c03\u8282\u9499\u78f7\u5e73\u8861\uff1b\u611f\u53d7\u529b\u5b66\u4fe1\u53f7\u3002\u4eba\u80ce\u513f\u6307\u9aa8&nbsp;A\u9aa8\u9886 B\u6210\u9aa8\u533a1\u9aa8\u7956\u7ec6\u80de2\u6210\u9aa8\u7ec6\u80de3\u9aa8\u7ec6\u80dePS\u9aa8\u819cBM\u9aa8\u57fa\u8d28\u4eba\u80ce\u513f\u6307\u9aa82\u6210\u9aa8\u7ec6\u80de3\u9aa8\u7ec6\u80de4\u7834\u9aa8\u7ec6\u80deBM\u9aa8\u57fa\u8d28CM\u8f6f\u9aa8\u57fa\u8d28\uff084\uff09\u7834\u9aa8\u7ec6\u80de&nbsp;(osteoclast\uff09\u591a\u6838\u5de8\u7ec6\u80de\uff1a\u76f4\u5f8430~150\u339b\uff0c\u68382~100\u4e2a\u6838\u5375\u5706\u5f62\uff0c\u67d3\u8272\u8d28\u9897\u7c92\u7ec6\u5c0f\uff0c\u8272\u6d45\uff0c\u6838\u4ec11~2\u4e2a\uff0c\u5e38\u89c4\u7ec4\u7ec7\u5207\u7247\u4e0a\uff0c\u80de\u8d28\u55dc\u9178\u6027\uff1b\u4e00\u5b9apH\u4e0b\uff0c\u7528\u78b1\u6027\u67d3\u6599\u67d3\u8272\uff0c\u80de\u8d28\u5f31\u55dc\u78b1\u6027\uff0c\u5373\u7834\u9aa8\u7ec6\u80de\u5177\u55dc\u53cc\u8272\u6027\u3002\u80de\u8d28\u5185\u6709\u8bb8\u591a\u5c0f\u7a7a\u6ce1\u6570\u91cf\u5c11\uff0c\u65e0\u5206\u88c2\u80fd\u529b\u5e38\u4f4d\u4e8e\u9aa8\u7ec4\u7ec7\u5438\u6536\u5904\u8868\u9762\uff0c\u5176\u5904\u5448\u6d45\u7684\u51f9\u9677\u79f0\u5438\u6536\u8154\u6216Howship\u9677\u7a9d\u3002\u529f\u80fd\u6d3b\u8dc3\u7684\u7834\u9aa8\u7ec6\u80de\u6709\u660e\u663e\u7684\u6781\u6027\u7535\u955c\u4e0b\u52064\u4e2a\u533a\uff1a\u7d27\u8d34\u9aa8\u7ec4\u7ec7\u4fa7\u7684\u7ec6\u80de\u819c\u548c\u7ec6\u80de\u8d28\u4b26\u4e3a\u76b1\u8936\u7f18(ruffled border)\u533a\u548c\u4eae\u533a\u3002\u76b1\u8936\u7f18\u533a\u4f4d\u4e8e\u5438\u6536\u8154\u6df1\u5904\uff0c\u662f\u7834\u9aa8\u7ec6\u80de\u8868\u9762\u8d77\u4f0f\u4e0d\u5e73\u7684\u90e8\u5206\u5149\u955c\u4e0b\u4f3c\u7eb9\u72b6\u7f18\uff0c\u7531\u5185\u9677\u5f88\u6df1\u7684\u8d28\u819c\u5185\u8936\u7ec4\u6210\uff0c\u5448\u73b0\u5927\u91cf\u53f6\u72b6\u7a81\u8d77\u6216\u6307\u72b6\u7a81\u8d77\uff0c\u7c97\u7ec6\u4e0d\u5747\uff0c\u8fdc\u4fa7\u7aef\u81a8\u5927\uff0c\u5206\u652f\u543b\u5408\uff0cATP\u9176\u548c\u9178\u6027\u78f7\u9178\u9176\u6cbf\u76b1\u8936\u7f18\u7ec6\u80de\u819c\u5206\u5e03\u3002\u76b1\u8936\u7f18\u6e38\u79bb\u4fa7\u7ec6\u80de\u819c\u6781\u5316\u4ea7\u751f\u72ec\u7acb\u7684\u9876\u7aef\u533a\u548c\u57fa\u4fa7\u533a\u3002\u4eae\u533a\u6216\u5c01\u95ed\u533a\uff1a\u73af\u7ed5\u4e8e\u76b1\u8936\u7f18\u533a\u5468\u56f4\uff0c\u5fae\u5fae\u9686\u8d77\uff0c\u5e73\u6574\u7684\u7ec6\u80de\u819c\u7d27\u8d34\u9aa8\u7ec4\u7ec7\u5305\u56f4\u76b1\u8936\u7f18\u533a\u3002\u5207\u9762\u4e0a\u4e24\u5757\u5c01\u95ed\u533a\u4f4d\u4e8e\u76b1\u8936\u7f18\u4e24\u4fa7\uff0c\u5c01\u95ed\u533a\u6709\u4e30\u5bcc\u7684\u808c\u52a8\u86cb\u767d\u5fae\u4e1d\uff0c\u7535\u5b50\u5bc6\u5ea6\u4f4e\u3002\u5c0f\u6ce1\u533a\u4f4d\u4e8e\u76b1\u8936\u7f18\u6df1\u9762\uff0c\u5185\u542b\u8bb8\u591a\u5927\u5c0f\u4e0d\u4e00\u3001\u7535\u5b50\u5bc6\u5ea6\u4e0d\u7b49\u7684\u819c\u88ab\u5c0f\u6ce1\u6216\u5927\u6ce1\uff0c\u6709\u4e9b\u5927\u6ce1\u9178\u6027\u78f7\u9178\u9176\u9633\u6027\u3002\u5c0f\u533a\u8fd8\u6709\u8bb8\u591a\u5927\u5c0f\u4e0d\u4e00\u7684\u7ebf\u7c92\u4f53\u3002A\u6210\u9aa8\u7ec6\u80de 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ossification center\uff09\u5f62\u6210\u4e4b\u521d\uff0c\u8840\u7ba1\u8fde\u540c\u7834\u9aa8\u7ec6\u80de\u53ca\u95f4\u5145\u8d28\u7b49\u7ecf\u9aa8\u5916\u819c\u7a7f\u8d8a\u9aa8\u9886\uff0c\u8fdb\u5165\u9000\u5316\u8f6f\u9aa8\u533a\uff0c\u901a\u8fc7\u7834\u9aa8\u7ec6\u80de\u5206\u89e3\u5438\u6536\u9499\u5316\u7684\u8f6f\u9aa8\u57fa\u8d28\uff0c\u5f62\u6210\u8bb8\u591a\u4e0e\u539f\u59cb\u9aa8\u5e72\u957f\u8f74\u5e73\u884c\u7684\u96a7\u9053\u3002\u96a7\u9053\u7684\u58c1\u4e3a\u6b8b\u5b58\u7684\u9499\u5316\u8f6f\u9aa8\u57fa\u8d28\uff0c\u96a7\u9053\u7684\u8154\u5373\u521d\u7ea7\u9aa8\u9ad3\u8154\u3002\u8154\u5185\u5145\u4ee5\u6765\u81ea\u95f4\u5145\u8d28\u7684\u9aa8\u539f\u7ec6\u80de\u548c\u6210\u9aa8\u7ec6\u80de\uff0c\u4ee5\u53ca\u7834\u9aa8\u7ec6\u80de\u548c\u6b63\u5728\u5f62\u6210\u4e2d\u7684\u9020\u8840\u7ec4\u7ec7\u7b49\uff0c\u7edf\u79f0\u521d\u7ea7\u9aa8\u9ad3\uff08primary bone 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\u957f\u9aa8\u53d1\u751f\u4e0e\u751f\u957f\uff081\uff09\uff5e\uff087\uff09\u793a\u8f6f\u9aa8\u5185\u6210\u9aa8\u53ca\u957f\u9aa8\u751f\u957f&nbsp;&nbsp;\uff088\uff09\u793a\u8f6f\u9aa8\u88ab\u9aa8\u53d6\u4ee3\u8fc7\u7a0b\u8f6f\u9aa8\u50a8\u5907\u533a\uff08zone of reserve cartilage\uff09\uff1a\u8f6f\u9aa8\u7ec6\u80de\u8f83\u5c0f\uff0c\u5206\u6563\u5b58\u5728\u3002\u8f6f\u9aa8\u57fa\u8d28\u5448\u5f31\u55dc\u78b1\u6027\u3002\u8f6f\u9aa8\u589e\u751f\u533a\uff08zone of proliferating cartilage\uff09\uff1a\u8f6f\u9aa8\u7ec6\u80de\u8f83\u5927\uff0c\u901a\u8fc7\u5206\u88c2\u5f62\u6210\u7684\u540c\u6e90\u7ec6\u80de\u7fa4\u7eb5\u5217\u6210\u884c\uff0c\u5f62\u6210\u8f6f\u9aa8\u7ec6\u80de\u67f1\u3002\u8f6f\u9aa8\u9499\u5316\u533a\uff08zone of calcifying cartilage\uff09\uff1a\u8f6f\u9aa8\u7ec6\u80de\u80a5\u5927\uff0c\u5448\u7a7a\u6ce1\u72b6\uff0c\u6838\u56fa\u7f29\uff0c\u53ef\u89c1\u9000\u5316\u6b7b\u4ea1\u8f6f\u9aa8\u7ec6\u80de\u7559\u4e0b\u7684\u5927\u9677\u7a9d\u3002\u9499\u5316\u7684\u8f6f\u9aa8\u57fa\u8d28\u5448\u5f3a\u55dc\u78b1\u6027\u3002\u6210\u9aa8\u533a\uff08zone of ossification\uff09\uff1a\u53ef\u89c1\u4e2d\u8f74\u4e3a\u9499\u5316\u8f6f\u9aa8\u57fa\u8d28\u548c\u8868\u9762\u4e3a\u9aa8\u7ec4\u7ec7\u7684\u8fc7\u6e21\u578b\u9aa8\u5c0f\u6881\uff0c\u5c0f\u6881\u4e4b\u95f4\u4e3a\u96a7\u9053\u5f0f\u521d\u7ea7\u9aa8\u9ad3\u8154\u3002\u8154\u5185\u6709\u9020\u8840\u7ec4\u7ec7\u53ca\u8840\u7ba1\uff0c\u8154\u58c1\uff08\u5373\u9aa8\u5c0f\u6881\u8868\u9762\uff09\u53ef\u89c1\u6210\u9aa8\u7ec6\u80de\u9644\u7740\uff0c\u7834\u9aa8\u7ec6\u80de\u4e5f\u9644\u9aa8\u5c0f\u6881\u8868\u9762\uff0c\u9644\u7740\u5904\u6709\u51f9\u9677\uff0c\u8868\u660e\u6b64\u5904\u7684\u9aa8\u57fa\u8d28\u5df2\u88ab\u5206\u89e3\u5438\u6536\u3002\uff08c\uff09\u6b21\u7ea7\u9aa8\u5316\u4e2d\u5fc3\u51fa\u73b0\u53ca\u9aa8\u9aba\u5f62\u6210\uff1a\u6b21\u7ea7\u9aa8\u5316\u4e2d\u5fc3\uff08secondary ossification center\uff09\u51fa\u73b0\u7684\u65f6\u95f4\u56e0\u9aa8\u800c\u5f02\uff0c\u65e9\u81ea\u51fa\u751f\u524d\uff0c\u665a\u81f3\u51fa\u751f\u540e\u6570\u6708\u6216\u6570\u5e74\u4e0d\u7b49\u3002\u51fa\u73b0\u7684\u90e8\u4f4d\u5728\u9aa8\u5e72\u4e24\u7aef\u7684\u8f6f\u9aa8\u4e2d\u592e\u3002\u6b21\u7ea7\u9aa8\u5316\u4e2d\u5fc3\u7684\u53d1\u751f\u8fc7\u7a0b\u4e0e\u521d\u7ea7\u9aa8\u5316\u4e2d\u5fc3\u76f8\u4f3c\u3002\u4f46\u9aa8\u5316\u662f\u4ece\u4e2d\u592e\u5448\u8f90\u5c04\u72b6\u5411\u56db\u5468\u8fdb\u884c\u7684\u3002\u6700\u540e\u4ee5\u521d\u7ea7\u9aa8\u677e\u8d28\u53d6\u4ee3\u7edd\u5927\u90e8\u5206\u8f6f\u9aa8\u7ec4\u7ec7\uff0c\u4f7f\u9aa8\u5e72\u4e24\u7aef\u8f6c\u53d8\u6210\u4e3a\u65e9\u671f\u9aa8\u9aba\u3002\u9aba\u7aef\u8868\u9762\u59cb\u7ec8\u4fdd\u7559\u8584\u5c42\u8f6f\u9aa8\uff0c\u5373\u5173\u8282\u8f6f\u9aa8\u3002\u65e9\u671f\u9aa8\u9aba\u4e0e\u9aa8\u5e72\u4e4b\u95f4\u4ea6\u4fdd\u7559\u4e00\u5b9a\u539a\u5ea6\u7684\u8f6f\u9aa8\u5c42\uff0c\u5373\u9aba\u8f6f\u9aa8\uff0c\u79f0\u9aba\u677f(epiphyseal 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