\u6574\u7406\uff1a\u80bf\u7624\u8d44\u8baf\u6765\u6e90\uff1a\u80bf\u7624\u8d44\u8baf<\/p>\n
\u4e73\u817a\u764c\u662f\u5168\u7403\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u6076\u6027\u80bf\u7624\uff0c\u5176\u4e2dHR+\/HER2-\u4e73\u817a\u764c\u7ea6\u5360\u5168\u90e8\u4e73\u817a\u764c\u768465%-70%[1]\u3002\u5e78\u8fd0\u7684\u662f\uff0cHR+\/HER2-\u4e73\u817a\u764c\u4f7f\u7528\u5185\u5206\u6ccc\u8f85\u52a9\u6cbb\u7597\u7684\u751f\u5b58\u9884\u540e\u8f83\u597d\u3002\u968f\u7740\u5185\u5206\u6ccc\u6cbb\u7597\u7684\u5e7f\u6cdb\u5e94\u7528\uff0c\u5185\u5206\u6ccc\u8010\u836f\u6210\u4e3a\u4e34\u5e8a\u4e0a\u9762\u4e34\u7684\u68d8\u624b\u95ee\u9898\u3002\u76ee\u524d\uff0c\u5bf9\u4e8e\u5185\u5206\u6ccc\u8010\u836fHR+\/HER2-\u4e73\u817a\u764c\uff0cCDK4\/6\u6291\u5236\u5242\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\u662f\u4e00\u7ebf\u4f18\u9009\uff0c\u82e5\u8fdb\u5c55\u5219\u9009\u7528\u5176\u4ed6\u9776\u5411\u836f\u7269\u6216\u8fdb\u884c\u5316\u7597[2]\uff0c\u4f46\u5185\u5206\u6ccc\u8010\u836f\u540e\u7684\u6cbb\u7597\u9009\u62e9\u751f\u5b58\u671f\u4ecd\u7136\u6709\u9650\uff0c\u4e3a\u89e3\u51b3\u5185\u5206\u6ccc\u8010\u836f\u540e\u5982\u4f55\u9009\u62e9\u6cbb\u7597\u65b9\u6848\u7684\u95ee\u9898\uff0c\u5b66\u754c\u8fdb\u884c\u4e86\u591a\u65b9\u9762\u7684\u63a2\u7d22\u3002\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\u88ab\u79f0\u4e3a\u201c\u9b54\u6cd5\u5b50\u5f39\u201d\uff0c\u53ef\u7279\u5f02\u6027\u9776\u5411\u8868\u8fbe\u9776\u6297\u539f\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u4ece\u800c\u7cbe\u51c6\u6253\u51fb\u80bf\u7624\u7ec6\u80de\u3002\u800cTrop-2\u662fADC\u7684\u70ed\u95e8\u9776\u70b9\uff0c\u5728\u6240\u6709\u4e73\u817a\u764c\u4e9a\u578b\u4e2d\u5747\u9ad8\u8868\u8fbe\uff0c\u5728\u6b63\u5e38\u7684\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u8f83\u4f4e[3]\u3002Trop-2 ADC\u662f\u4e00\u79cd\u6781\u5177\u6f5c\u529b\u7684\u7528\u4e8e\u5185\u5206\u6ccc\u8010\u836f\u540e\u7684\u9776\u5411\u6cbb\u7597\u3002<\/p>\n
\u672c\u6b21\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u62a5\u9053\u4e86\u65b0\u578bTrop-2 ADC Dato-DXd\u7684\u5173\u952e\u6027III\u671f\u4e34\u5e8a\u7814\u7a76TROPION-Breast01\u7684\u7ed3\u679c\uff08\u6458\u8981\u53f7\uff1aLBA11\uff09\uff0c\u4e3a\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u8fdb\u5c55\u7684HR+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u9009\u62e9[4]\u3002<\/p>\n
\u4e3a\u6b64\uff0c\u672c\u671f\u7279\u9080\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u7b2c\u56db\u533b\u9662\u803f\u7fe0\u829d\u6559\u6388\u7ed3\u5408\u9886\u57df\u73b0\u72b6\uff0c\u70b9\u8bc4\u672c\u6b21\u6570\u636e\uff0c\u5c55\u671bHR+\u4e73\u817a\u764c\u6cbb\u7597\u524d\u666f\u3002<\/p>\n
\u672c\u671f\u7279\u9080\u4e13\u5bb6\u2014\u2014\u803f\u7fe0\u829d \u6559\u6388<\/p>\n
\u803f\u7fe0\u829d \u6559\u6388\u5916\u79d1\u5b66\u535a\u58eb\uff0c\u4e3b\u4efb\u533b\u5e08\uff0c\u4e8c\u7ea7\u6559\u6388\uff0c\u535a\u58eb\u751f\u5bfc\u5e08<\/p>\n
\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u4e73\u817a\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u4e73\u817a\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u5e38\u59d4\u4e2d\u534e\u533b\u5b66\u4f1a\u80bf\u7624\u5b66\u5206\u4f1a\u4e73\u817a\u764c\u5b66\u7ec4\u59d4\u5458\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u4e73\u817a\u75be\u75c5\u4e13\u5bb6\u57f9\u8bad\u59d4\u5458\u4f1a\u5e38\u59d4\u6cb3\u5317\u7701\u4e73\u817a\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e3b\u4efb\u59d4\u5458<\/p>\n
TROPION-Breast01\u5173\u952e\u7814\u7a76\u6570\u636e\u516c\u5e03[4]<\/p>\n
\u4e3a\u5185\u5206\u6ccc\u8010\u836f\u540e\u6cbb\u7597\u5e26\u6765\u65b0\u9009\u62e9<\/p>\n
TROPION-Breast01\u662f\u4e00\u9879\u5168\u7403\u3001\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7eIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u63a2\u7d22Dato-DXd\u5bf9\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\uff08ICC\uff09\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc71-2\u7ebf\u5316\u7597\u3001\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u8fdb\u5c55\u6216\u4e0d\u9002\u5408\u5185\u5206\u6ccc\u6cbb\u7597\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\uff08\u5305\u62ecHER2\u4f4e\u8868\u8fbe\u3001HER2\u96f6\u8868\u8fbe\u4eba\u7fa4\uff09\u3002\u6309\u71671\uff1a1\u6bd4\u4f8b\u968f\u673a\u5206\u81f3Dato-DXd\u7ec4\u548cICC\u7ec4\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u76f2\u6001\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\uff08BICR\uff09\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u4e3a\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u3001\u7814\u7a76\u8005\u8bc4\u4f30\uff08INV\uff09\u7684PFS\u3001\u5b89\u5168\u6027\u3002<\/p>\n
TROPION-Breast01\u7814\u7a76\u7684\u7814\u7a76\u8bbe\u8ba1\u548c\u5165\u6392\u6807\u51c6<\/p>\n
\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cTROPION-Breast01\u7814\u7a76\u7684\u5165\u7ec4\u4eba\u7fa4\u4e2d\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7CDK4\/6\u6291\u5236\u5242\u6cbb\u7597\u7684HR+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u536082%\uff0c100%\u662f\u5316\u7597\u7ecf\u6cbb\u7684\u540e\u7ebf\u60a3\u8005\uff0c\u662f\u65e2\u5f80\u4e34\u5e8a\u4e0a\u6cbb\u7597\u9009\u62e9\u975e\u5e38\u6709\u9650\u7684\u4eba\u7fa4\u3002<\/p>\n
TROPION-Breast01\u7814\u7a76\u5165\u7ec4\u4eba\u7fa4\u57fa\u7ebf\u60c5\u51b5<\/p>\n
\u7ed3\u679c\u663e\u793a\uff0cDato-DXd\u76f8\u6bd4ICC\u6cbb\u7597\u5185\u5206\u6ccc\u8010\u836f\u6216\u65e2\u5f80\u7ecf1-2\u7ebf\u5316\u7597\u6cbb\u7597\u7684HR+\/HER2-\u665a\u671f\u4e73\u817a\u764cBCIR\u8bc4\u4f30\u7684PFS\u4e3a6.9\u4e2a\u6708 vs. 4.9\u4e2a\u6708\uff0cHR=0.63\uff0895%CI 0.52-0.76\uff09\uff1bINV\u8bc4\u4f30\u7684PFS\u4e3a6.9\u4e2a\u6708 vs. 4.5\u4e2a\u6708\uff0cHR=0.64\uff0c\uff0895%CI 0.53-0.76\uff09\u3002\u65e0\u8bba\u662fBICR\u8fd8\u662fINV\u8bc4\u4f30\u7684PFS\u90fd\u4e00\u81f4\u663e\u793a\uff0cDato-DXd\u53ef\u663e\u8457\u5ef6\u957f\u60a3\u8005PFS\u3002<\/p>\n
TROPION-Breast01\u7814\u7a76PFS<\/p>\n
\u6240\u6709\u4e9a\u7ec4\u5747\u503e\u5411\u4e8eDato-DXd\u7684\u83b7\u76ca\uff0c\u5bf9\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7CDK4\/6\u6291\u5236\u5242\u6cbb\u7597\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\uff0c\u76f8\u6bd4\u4e8e\u540e\u7eed\u5316\u7597\uff0cDato-DXd\u53ef\u964d\u4f4e\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\uff08HR=0.62\uff09\u3002\u65e0\u8bba\u79cd\u65cf\u3001\u5e74\u9f84\uff08\uff1c65\u5c81\u60a3\u8005\uff0c\u6216\u662f\u226565\u5c81\u8001\u5e74\u60a3\u8005\uff09\u8fd8\u662f\u65e2\u5f80\u5316\u7597\u7ebf\u6570\u5982\u4f55\uff0cDATO-DXd\u5747\u53ef\u964d\u4f4e\u60a3\u8005\u7684\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\u3002<\/p>\n
TROPION-Breast01\u7814\u7a76\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c<\/p>\n
Dato-DXd\u7ec4\u7684ORR\u4e3a36.4%\uff0c\u800cICC\u7ec4\u4e3a22.9%\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u591a\u7ebf\u7ecf\u6cbb\u7684\u60a3\u8005\u4e2d\uff0c\u4f7f\u7528Dato-DXd\u6cbb\u7597\u67090.5%\u60a3\u8005\u53ef\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u3002\u53ef\u89c1\u76f8\u8f83\u4e8e\u5316\u7597\uff0cDato-DXd\u5bf9\u75be\u75c5\u63a7\u5236\u7684\u6548\u679c\u66f4\u4f73\u3002OS\u6570\u636e\u5c1a\u4e0d\u6210\u719f\uff0c\u4f46\u89c2\u5bdf\u5230Dato-DXd\u7ec4\u7597\u6548\u66f4\u4f18\u7684\u83b7\u76ca\u8d8b\u52bf\u3002<\/p>\n
TROPION-Breast01\u7814\u7a76\u7f13\u89e3\u60c5\u51b5\u548c\u751f\u5b58<\/p>\n
\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0cDato-DXd\u7ec4\u4e3b\u8981\u662f1-2\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u3002\u63a5\u53d7Dato-DXd\u6cbb\u7597\u7684\u60a3\u8005\u22653\u7ea7TRAEs\u53d1\u751f\u7387\u4e3a21%\uff0c\u800cICC\u7ec4\u4e3a45%\uff0cDato-DXd\u7684\u22653\u7ea7TRAEs\u4ec5\u4e3aICC\u7ec4\u7684\u4e00\u534a\u3002Dato\u7ec4\u548cICC\u7ec4\u56e0TRAEs\u5bfc\u81f4\u51cf\u91cf\u7684\u53d1\u751f\u7387\u4e3a21% vs. 30%\uff0c\u56e0TRAEs\u5bfc\u81f4\u4e2d\u65ad\u6cbb\u7597\u7684\u53d1\u751f\u7387\u4e3a12% vs. 25%\u3002\u5316\u7597\u7ec4\u51fa\u73b01\u4f8b\u56e0TRAEs\u5bfc\u81f4\u6b7b\u4ea1\u3002<\/p>\n
TROPION-Breast01\u7814\u7a76\u603b\u4f53\u5b89\u5168\u6027\u60c5\u51b5<\/p>\n
TROPION-Breast01\u7814\u7a76\u8fbe\u5230\u4e86BICR\u8bc4\u4f30PFS\u3001INV\u8bc4\u4f30PFS\u7684\u53cc\u7ec8\u70b9\uff0c\u786e\u8bc1\u4e86Dato-DXd\u5728\u5185\u5206\u6ccc\u8010\u836f\u3001\u65e2\u5f80\u7ecf1-2\u7ebf\u5316\u7597HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u7597\u6548\u3002Dato-DXd\u6cbb\u7597\u8fd9\u90e8\u5206\u4eba\u7fa4\u7684ORR\u8fbe36.4%\uff0c\u76f8\u6bd4\u5316\u7597\u663e\u8457\u63d0\u5347\u3002\u800c\u4e14\uff0c\u5b89\u5168\u6027\u603b\u4f53\u4f18\u7531\u4e8e\u5316\u7597\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u7ecf\u5386\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684HR+\/HER2-\u665a\u671f\u60a3\u8005\u800c\u8a00\uff0cDato-DXd\u5bf9\u6bd4\u5316\u7597\u6709\u671b\u6210\u4e3a\u4e00\u79cd\u7597\u6548\u597d\u3001\u8010\u53d7\u6027\u4ee5\u53ca\u5b89\u5168\u6027\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n
Trop-2 ADC\u7814\u7a76\u76d8\u70b9<\/p>\n
\u76ee\u524d\uff0cTrop-2 ADC\u5728\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u540e\u7ebf\u6cbb\u7597\u7684\u7597\u6548\u5df2\u7ecf\u88ab\u786e\u8bc1\uff0c\u4e5f\u53ef\u4f5c\u4e3a\u5185\u5206\u6ccc\u8010\u836f\u6216\u8005\u4f34\u6709\u5185\u810f\u5371\u8c61\u7684HR+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u9009\u62e9[5]\u3002\u672c\u6b21ESMO\u4f1a\u8bae\u4e0a\u516c\u5e03\u4e86Dato-DXd\u3001\u6208\u6c99\u59a5\u73e0\u5355\u6297\uff08SG\uff09\u548cSKB264\u7684\u7814\u7a76\u7ed3\u679c\u3002\u5c3d\u7ba1ADC\u5728\u836f\u7269\u7ed3\u6784\u4e0a\u76f8\u4f3c\uff0c\u4f46\u642d\u8f7d\u7684\u7ec6\u80de\u6bd2\u836f\u7269\u3001\u8fde\u63a5\u5b50\u5747\u6709\u5dee\u5f02\u3002\u25cf Dato-DXd\u7531\u4eba\u6e90\u5316\u6297Trop-2 IgG1\u5355\u514b\u9686\u6297\u4f53\u4e0e\u6709\u6548\u8f7d\u8377\u5f3a\u6548\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242DXd\u901a\u8fc7\u7a33\u5b9a\u7684\u56db\u80bd\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u5076\u8054\u800c\u6210\u3002\u25cf SG\u7531\u9776\u5411\u764c\u7ec6\u80deTrop-2\u86cb\u767d\u6297\u4f53sacituzumab\uff0c\u548c\u4f0a\u7acb\u66ff\u5eb7\u7c7b\u4f3c\u7269SN-38\u7ed3\u5408\u800c\u6210\u3002\u25cf SKB264\u7531\u4eba\u6e90\u5316\u6297Trop-2\u5355\u6297\uff0c\u901a\u8fc7CL2A\u8fde\u63a5\u5b50\uff08\u8fde\u63a5\u5b50\u7684\u6297\u4f53\u7aef\u91c7\u7528\u7532\u78fa\u9170\u57fa\u5627\u5576\u5b9e\u73b0\u4e0e\u6297\u4f53\u4e0d\u53ef\u9006\u5076\u8054\uff09\uff0c\u4e0e\u81ea\u7814\u6bd2\u7d20\u5c0f\u5206\u5b50T030\uff08\u62d3\u6251\u5f02\u6784\u9176\u2160\u6291\u5236\u5242\uff09\u7ed3\u5408\u800c\u6210\u3002<\/p>\n
Dato-DXd\u7684\u836f\u7269\u7ed3\u6784<\/p>\n
SKB264\u76ee\u524d\u5c1a\u5904\u4e8eI\/II\u671f\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u3002\u800cDato-DXd\u3001SG\u5747\u516c\u5e03\u4e86III\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3002<\/p>\n
* \u4e0d\u540c\u836f\u7269\u4e4b\u95f4\u7684\u975e\u5934\u5bf9\u5934\u7814\u7a76\uff0c\u7814\u7a76\u7ed3\u679c\u4e0d\u53ef\u76f4\u63a5\u6bd4\u8f83<\/p>\n
Dato-DXd\u6cbb\u7597\u524d\u666f\u5e7f\u9614\uff0c\u6216\u5c06\u6539\u53d8\u4e73\u817a\u764c\u751f\u5b58\u7ed3\u5c40<\/p>\n
HR+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u7684\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u4e3aCDK4\/6\u6291\u5236\u5242\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\u3002\u968f\u7740CDK4\/6\u6291\u5236\u5242\u5728\u4e34\u5e8a\u666e\u53ca\uff0cCDK4\/6\u6291\u5236\u5242\u539f\u53d1\u6027\u6216\u7ee7\u53d1\u6027\u8010\u836f\u6210\u4e3a\u4e34\u5e8a\u4e9f\u9700\u89e3\u51b3\u7684\u95ee\u9898\u3002TROPION-Breast01\u7814\u7a76\u5165\u7ec4\u4eba\u7fa4\u4e2d\u7eb3\u5165\u4e86\u8f83\u9ad8\u6bd4\u4f8b\u7684\u65e2\u5f80\u4f7f\u7528\u8fc7CDK4\/6\u6291\u5236\u5242\u60a3\u8005\uff0c\u536082%\u3002\u5728\u8fd9\u90e8\u5206CDK4\/6\u6291\u5236\u5242\u7ecf\u6cbb\u7684\u60a3\u8005\u4e2d\uff0cDato-DXd\u53ef\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\/\u6b7b\u4ea1\u98ce\u966938%\uff08HR=0.62\uff09\u3002\u8fd9\u65e0\u7591\u4e3aCDK4\/6\u6291\u5236\u5242\u7ecf\u6cbb\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u63d0\u4f9b\u8f83\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002\u5728\u53e6\u4e00\u9879\u9488\u5bf9\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027TNBC\u4e00\u7ebf\u6cbb\u7597\u7684\u591a\u4e2d\u5fc3\u3001\u591a\u81c2\u3001\u5f00\u653e\u6807\u7b7eIb\/II\u671fBEGONIA\u7814\u7a76\u4e2d\uff0cDato-DXd\u8054\u5408\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u5c55\u73b0\u4e86\u8f83\u597d\u7684\u6cbb\u7597\u6570\u636e\u3002\u5176\u4e2d\uff0c\u961f\u52177\u5165\u7ec462\u4f8b\u60a3\u8005\uff0c\u65e0\u8bbaPD-L1\u548cTrop-2\u8868\u8fbe\u72b6\u6001\u3002\u7ed3\u679c\u663e\u793a\uff0c\u786e\u8ba4\u7684ORR\u4e3a79%\uff0cCR\u7387\u4e3a10%\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u4e3a15.5\u4e2a\u6708\uff0c\u4e2d\u4f4dPFS\u4e3a13.8\u4e2a\u6708\u3002\u9700\u6ce8\u610f\u7684\u662f\uff0c\u5165\u7ec4\u60a3\u8005\u4e2d87%\u60a3\u8005\u4e3aPD-L1\u4f4e\u8868\u8fbe\u3002\u8fd9\u610f\u5473\u7740\u5bf9\u4e8ePD-L1\u4f4e\u8868\u8fbe\u7684TNBC\u60a3\u8005\uff0cADC\u8054\u5408PD-1\u6291\u5236\u5242\u662f\u4e00\u79cd\u6709\u6f5c\u529b\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u672a\u6765\u6216\u5c06\u8fdb\u4e00\u6b65\u5ef6\u957f\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u6539\u5584\u751f\u6d3b\u8d28\u91cf[9]\u3002\u968f\u7740ADC\u65f6\u4ee3\u7684\u5230\u6765\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u836f\u7269\u53ef\u4f9b\u9009\u62e9\uff0c Dato-DXd\u5355\u836f\u6216\u8054\u5408\u6cbb\u7597\u7ed9HR+\/HER2-\u4e73\u817a\u764c\u3001TNBC\u5e26\u6765\u6709\u5e0c\u671b\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u586b\u8865\u4e86\u4e34\u5e8a\u6cbb\u7597\u7684\u7a7a\u767d\u3002\u672a\u6765\u5982\u4f55\u8fdb\u884c\u4e0d\u540c\u9776\u70b9\u7684ADC\u7684\u533a\u9694\uff0c\u5982\u4f55\u8fdb\u884cADC\u8010\u836f\u540e\u7684\u9009\u62e9\u90fd\u662f\u503c\u5f97\u63a2\u8ba8\u548c\u7814\u7a76\u7684\u65b9\u5411\uff0c\u76f8\u4fe1\u672a\u6765Dato-DXd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u80fd\u591f\u5e26\u6765\u66f4\u591a\u4ee4\u4eba\u60ca\u559c\u7684\u7ed3\u679c\uff0c\u4e3a\u4e73\u817a\u764c\u60a3\u8005\u5e26\u6765\u751f\u5b58\u65b0\u5e0c\u671b\u3002<\/p>\n
\u53c2\u8003\u6587\u732e<\/p>\n
[1] Huppert, Laura A et al. CA: a cancer journal for clinicians vol. 73,5 (2023): 480-515. [2] \u5f20\u80e1\u4e91\u9f99,\u7b49.\u4e2d\u56fd\u4e34\u5e8a\u836f\u7406\u5b66\u4e0e\u6cbb\u7597\u5b66, 2023, 28(8):854-865.[3] Cardillo, Thomas M et al. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 17,10 (2011): 3157-69.[4] Aditya Bardia et al. 2023 ESMO LBA11.[5] NCCN Clinical Practice Guidelines in Oncology: Breast Cancer, Version 4. 2023 [6] Rugo HS, et al. J Clin Oncol. 2022 Aug 26:JCO2201002.[7] Sara M. Tolaney, et al. 2023 ASCO 1003 Oral Abstract Session.[8] Rugo, Hope S et al. Lancet (London, England) vol. 402,10411 (2023): 1423-1433. [9] 2023 ESMO\uff0c378MO.<\/p>\n
\u8d23\u4efb\u7f16\u8f91\uff1aAnnie \u6392\u7248\u7f16\u8f91\uff1a\u9093\u6587\u666e<\/p>\n","protected":false},"excerpt":{"rendered":"
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