{"id":62523,"date":"2025-12-28T05:10:48","date_gmt":"2025-12-28T05:10:48","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=62523"},"modified":"2025-12-28T05:10:48","modified_gmt":"2025-12-28T05:10:48","slug":"%e9%a5%ad%e7%82%b9%e5%bf%85%e7%9c%8b%ef%bc%81%e7%94%9f%e9%85%ae-vs-%e7%ba%af%e7%b4%a0%ef%bc%9a%e4%b8%8d%e5%90%8c%e9%a5%ae%e9%a3%9f%e5%a6%82%e4%bd%95%e5%bd%b1%e5%93%8d%e4%bd%a0%e7%9a%84%e5%85%8d","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=62523","title":{"rendered":"\u996d\u70b9\u5fc5\u770b\uff01\u751f\u916e vs. \u7eaf\u7d20\uff1a\u4e0d\u540c\u996e\u98df\u5982\u4f55\u5f71\u54cd\u4f60\u7684\u514d\u75ab\u7cfb\u7edf\uff1f"},"content":{"rendered":"<\/p>\n

\u56fe\u6e90\uff1apixabay<\/p>\n

\u91d1\u6a3d\u6e05\u9152\u6597\u5341\u5343\uff0c\u7389\u76d8\u73cd\u7f9e\u76f4\u4e07\u94b1\u3002\u54c1\u7c7b\u4e30\u5bcc\u3001\u98ce\u5473\u5404\u5f02\u7684\u73b0\u4ee3\u996e\u98df\u4e3a\u4e0d\u540c\u4eba\u7fa4\u7684\u4e0d\u540c\u9700\u6c42\u63d0\u4f9b\u4e86\u591a\u6837\u9009\u62e9\u3002<\/p>\n

\u4f8b\u5982\uff0c\u8fd1\u5e74\u6765\u5927\u706b\u7684\u751f\u916e\u996e\u98df\uff08ketogenic diet\uff09\uff0c\u8ffd\u6c42\u9ad8\u8102\u80aa\u3001\u4f4e\u78b3\u6c34\u5316\u5408\u7269\u3001\u9002\u91cf\u86cb\u767d\u8d28\u7684\u996e\u98df\u7ed3\u6784\uff1b\u6b64\u5916\u8fd8\u6709\u6211\u4eec\u719f\u77e5\u7684\u7eaf\u7d20\u3001\u5730\u4e2d\u6d77\u996e\u98df\uff08\u4ee5\u852c\u83dc\u6c34\u679c\u3001\u9c7c\u7c7b\u3001\u4e94\u8c37\u6742\u7cae\u3001\u8c46\u7c7b\u548c\u6a44\u6984\u6cb9\u4e3a\u4e3b\uff09\u7b49\u996e\u98df\u7ed3\u6784\u3002<\/p>\n

2024\u5e741\u670830\u65e5\uff0c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u4eba\u7c7b\u514d\u75ab\u5b66\u4e2d\u5fc3\u7684 Yasmine Belkaid\u3001Kevin D. Hall \u548c Verena M. Link \u56e2\u961f\u5728 Nature Medicine\uff08IF=82.9\uff09\u4e0a\u53d1\u8868\u4e86\u65b0\u7684\u7814\u7a76 Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans\u3002<\/p>\n<\/p>\n

\u56fe1 \u8bba\u6587\u622a\u56fe<\/p>\n

\u7814\u7a76\u901a\u8fc7\u5bf9\u53c2\u4e0e\u8005\u8fdb\u884c\u751f\u916e\u548c\u7eaf\u7d20\u996e\u98df\u7684\u4ea4\u53c9\u7814\u7a76\uff0c\u5168\u9762\u63a2\u8ba8\u4e86\u4e24\u79cd\u996e\u98df\u5bf9\u514d\u75ab\u7cfb\u7edf\u3001\u86cb\u767d\u8d28\u7ec4\u3001\u5fae\u751f\u7269\u7ec4\u4ee5\u53ca\u5bbf\u4e3b\u4ee3\u8c22\u7684\u5e7f\u6cdb\u548c\u5dee\u5f02\u6027\u5f71\u54cd\u3002\u7ed3\u8bba1\uff1a\u996e\u98df\u5e72\u9884\u6539\u53d8\u6dcb\u5df4\u7ec4\u6210<\/p>\n

\u7814\u7a76\u4eba\u5458\u9996\u5148\u63cf\u8ff0\u4e86\u5bf920\u540d\u53c2\u4e0e\u8005\u8fdb\u884c\u7684\u9ad8\u5ea6\u63a7\u5236\u7684\u996e\u98df\u7814\u7a76\u3002\u53c2\u4e0e\u8005\u5728\u4e24\u5468\u5185\u968f\u673a\u8fdb\u884c\u4e86\u751f\u916e\uff08ketogenic\uff09\u548c\u7eaf\u7d20\uff08vegan\uff09\u4e24\u79cd\u996e\u98df\uff0c\u901a\u8fc7\u91c7\u7528\u591a\u79cd\u6280\u672f\uff08\u5305\u62ec\u6d41\u5f0f\u7ec6\u80de\u672f\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u7ec4\u5b66\u3001\u4ee3\u8c22\u7ec4\u5b66\u548c\u5fae\u751f\u7269\u7ec4\u5b66\u7b49\uff09\u6765\u8bc4\u4f30\u4e24\u79cd\u996e\u98df\u5bf9\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u548c\u5fae\u751f\u7269\u7ec4\u7684\u5f71\u54cd\u3002<\/p>\n

\u7814\u7a76\u4e2d\u751f\u916e\u996e\u98df\u4ee5\u9ad8\u8102\u80aa\u4f4e\u78b3\u6c34\u5316\u5408\u7269\u4e3a\u4e3b\uff0875.8% \u8102\u80aa\uff0c10.0% \u78b3\u6c34\u5316\u5408\u7269\uff09\uff0c\u800c\u7eaf\u7d20\u996e\u98df\u4ee5\u4f4e\u8102\u80aa\u9ad8\u78b3\u6c34\u5316\u5408\u7269\u4e3a\u4e3b\uff0810.3 \uff05\u8102\u80aa\uff0c75.2\uff05\u78b3\u6c34\u5316\u5408\u7269\uff09\u3002\u4e24\u8005\u5747\u5305\u62ec\u5927\u91cf\u975e\u6dc0\u7c89\u852c\u83dc\uff08\u6bcf\u5929\u7ea61\u516c\u65a4\uff09\uff0c\u4f46\u751f\u916e\u996e\u98df\u6dfb\u52a0\u4e86\u52a8\u7269\u5236\u54c1\uff0c\u800c\u7eaf\u7d20\u996e\u98df\u5219\u6dfb\u52a0\u4e86\u8c46\u7c7b\u3001\u7c73\u3001\u6839\u830e\u852c\u83dc\u7b49\u3002\u4e24\u79cd\u996e\u98df\u7684\u80fd\u91cf\u6444\u5165\u548c\u6210\u5206\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002<\/p>\n

\u7814\u7a76\u4f7f\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\uff08flow cytometry \uff09\u5bf9\u5916\u5468\u8840\u5355\u4e2a\u6838\u7ec6\u80de\uff08PBMCs\uff09\u8fdb\u884c\u4e86\u5206\u6790\u3002\u7ed3\u679c\u663e\u793a\uff0c\u996e\u98df\u7684\u6539\u53d8\u672c\u8eab\u5bf9\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u4ea7\u751f\u663e\u8457\u5f71\u54cd\uff0c\u4e0d\u540c\u996e\u98df\u4e4b\u95f4\u548c\u76f8\u5bf9\u4e8e\u57fa\u7840\u996e\u98df\uff0c\u6dcb\u5df4\u7ec6\u80de\u7684\u7ec4\u6210\u53d1\u751f\u663e\u8457\u53d8\u5316\u3002\u4f8b\u5982\uff0c\u996e\u98df\u6539\u53d8\u5bfc\u81f4\u6d3b\u5316CD4\u548cCD8 T\u7ec6\u80de\u7684\u663e\u8457\u589e\u52a0\uff0c\u4ee5\u53ca\u6d3b\u5316\u8c03\u8282\u6027T\u7ec6\u80de\u548cCD16+<\/sup>\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u7684\u663e\u8457\u53d8\u5316\u3002<\/p>\n<\/p>\n

\u56fe2 NK\u7ec6\u80de\u548cT\u7ec6\u80de\u5728\u996e\u98df\u6539\u53d8\u4e2d\u53d7\u5230\u663e\u8457\u5f71\u54cd\u7ed3\u8bba2\uff1a\u7eaf\u7d20\u548c\u751f\u916e\u996e\u98df\u5bfc\u81f4\u4e0d\u540c\u7684\u514d\u75ab\u7279\u5f81<\/p>\n

\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u5168\u8840RNA-seq\u5206\u6790\uff0c\u7814\u7a76\u4e86\u57fa\u7ebf\u548c\u4e0d\u540c\u996e\u98df\u6761\u4ef6\u4e0b\u7684\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\u3002\u7ed3\u679c\u8868\u660e\uff0c\u7eaf\u7d20\u548c\u751f\u916e\u996e\u98df\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u5dee\u5f02\uff0c\u6d89\u53ca\u5230\u4e86\u6574\u4f53\u514d\u75ab\u7cfb\u7edf\u7684\u4e0d\u540c\u65b9\u9762\u3002<\/p>\n

\u901a\u8fc7\u8840\u6db2\u6837\u672c\u7684RNA-seq\u5206\u6790\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e0d\u540c\u996e\u98df\u6761\u4ef6\u4e0b\u7684\u57fa\u56e0\u8868\u8fbe\u5dee\u5f02\u3002\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u663e\u793a\uff0c\u996e\u98df\u662f\u89e3\u91ca\u57fa\u56e0\u7ec4\u5dee\u5f02\u7684\u91cd\u8981\u56e0\u7d20\u3002\u7eaf\u7d20\u996e\u98df\u4e0e\u9002\u5e94\u6027\u514d\u75ab\u76f8\u5173\u7684\u9014\u5f84\u6709\u5173\uff0c\u800c\u751f\u916e\u996e\u98df\u4e0e\u514d\u75ab\u5e94\u7b54\u548cB\u7ec6\u80de\u7b49\u9014\u5f84\u6709\u5173\u3002<\/p>\n

\u4f7f\u7528\u8840\u6db2\u8f6c\u5f55\u6a21\u5757\uff08BTM\uff09\u5206\u6790\u548cHallmark\u5206\u6790\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u751f\u916e\u996e\u98df\u4e0e\u9002\u5e94\u6027\u514d\u75ab\u6807\u5fd7\u7269\u76f8\u5173\uff0c\u5305\u62ecT\u7ec6\u80de\u6fc0\u6d3b\u3001B\u7ec6\u80de\u548c\u6d46\u7ec6\u80de\u5bcc\u96c6\uff0c\u4ee5\u53caNK\u7ec6\u80de\u3002\u76f8\u53cd\uff0c\u7eaf\u7d20\u996e\u98df\u4e0e\u5148\u5929\u514d\u75ab\u6807\u5fd7\u7269\u76f8\u5173\uff0c\u540c\u65f6\u9884\u6d4b\u4e0e\u5e72\u6270\u7d20\u548c\u6297\u75c5\u6bd2\u53cd\u5e94\u6709\u5173\u7684\u9014\u5f84\u4e0a\u8c03\u3002\u540c\u65f6\uff0c\u7eaf\u7d20\u996e\u98df\u4e0e\u764c\u75c7\u76f8\u5173\u9014\u5f84\u7684\u6d3b\u5316\u7a0b\u5ea6\u9ad8\u4e8e\u751f\u916e\u996e\u98df\u3002\u8fd9\u8868\u660e\u4e24\u79cd\u996e\u98df\u5bf9\u514d\u75ab\u7cfb\u7edf\u7684\u5f71\u54cd\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002<\/p>\n

\u7136\u800c\uff0c\u8fd9\u4e9b\u7ed3\u679c\u5e76\u4e0d\u9884\u6d4b\u5bf9\u764c\u75c7\u7684\u6613\u611f\u6027\u6216\u7ed3\u5c40\u4ea7\u751f\u4efb\u4f55\u5dee\u5f02\u3002<\/p>\n

\u7ed3\u8bba3\uff1a\u751f\u916e\u996e\u98df\u5bf9\u86cb\u767d\u9176\u4f53\uff08proteosome\uff09\u7684\u5e7f\u6cdb\u5f71\u54cd<\/p>\n

\u7814\u7a76\u4eba\u5458\u4ece\u6240\u670920\u540d\u53c2\u4e0e\u8005\u7684\u8840\u6d46\u4e2d\u6d4b\u91cf\u4e86\u7ea61300\u79cd\u86cb\u767d\u8d28\u7684\u4e30\u5ea6\uff0c\u5e76\u5bf9\u5176\u8fdb\u884c\u4e86\u751f\u916e\u6216\u7eaf\u7d20\u996e\u98df\u540e\u7684\u6bd4\u8f83\u3002\u901a\u8fc7\u7ebf\u6027\u6df7\u5408\u6a21\u578b\uff08LME\uff09\u663e\u793a\u7d20\u98df\u548c\u751f\u916e\u996e\u98df\u5728\u4e0d\u540c\u7ec4\u53c2\u4e0e\u8005\u4e4b\u95f4\u7684\u86cb\u767d\u8d28\u4e30\u5ea6\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff08P=0.5624\uff09\uff0c\u65b9\u5dee\u5206\u6790\uff08ANOVA\uff09\u663e\u793a\u5728\u4e0d\u540c\u996e\u98df\u4e4b\u95f4\u6709\u90e8\u5206\u86cb\u767d\u8d28\u53d7\u5230\u663e\u8457\u5f71\u54cd\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u751f\u916e\u996e\u98df\u5bf9\u86cb\u767d\u8d28\u7684\u4e30\u5ea6\u5f71\u54cd\u6700\u5927\u3002\u4e0e\u7eaf\u7d20\u548c\u57fa\u7ebf\u996e\u98df\u76f8\u6bd4\uff0c\u6709107\u79cd\u86cb\u767d\u8d28\u5728\u57fa\u7ebf\u4e0e\u751f\u916e\u4e4b\u95f4\u663e\u8457\u53d8\u5316\uff0c\u800c\u5728\u57fa\u7ebf\u4e0e\u7eaf\u7d20\u4e4b\u95f4\u53ea\u670921\u79cd\u3002\u996e\u98df\u7684\u987a\u5e8f\u4e0d\u5f71\u54cd\u86cb\u767d\u8d28\u4e30\u5ea6\u7684\u53d8\u5316\uff0c\u800c\u751f\u916e\u996e\u98df\u5bf9\u591a\u79cd\u7ec4\u7ec7\u4e2d\u7684\u86cb\u767d\u8d28\u4ea7\u751f\u66f4\u5e7f\u6cdb\u7684\u5f71\u54cd\u3002<\/p>\n

\u63a5\u7740\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u4eceHuman Protein Atlas\u4e0b\u8f7d\u7684\u7ec4\u7ec7\u6ce8\u91ca\u6765\u5206\u6790\u53d7\u5f71\u54cd\u86cb\u767d\u8d28\u7684\u6765\u6e90\u3002\u751f\u916e\u996e\u98df\u5f71\u54cd\u4e86\u9884\u6d4b\u6765\u81ea\u591a\u79cd\u7ec4\u7ec7\u7684\u86cb\u767d\u8d28\uff0c\u5305\u62ec\u8840\u6db2\u3001\u5927\u8111\u548c\u9aa8\u9ad3\uff0c\u800c\u4e24\u79cd\u996e\u98df\u90fd\u5f71\u54cd\u4e86\u9884\u6d4b\u6765\u81ea\u809d\u810f\u548c\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98\u7684\u86cb\u767d\u8d28\uff08\u56fe3b\uff09\u3002\u56e0\u6b64\uff0c\u4e0e\u7d20\u98df\u76f8\u6bd4\uff0c\u751f\u916e\u996e\u98df\u53ef\u80fd\u5bf9\u5bbf\u4e3b\u86cb\u767d\u8d28\u7684\u5206\u6ccc\u6216\u6e05\u9664\u4ea7\u751f\u66f4\u5e7f\u6cdb\u7684\u5f71\u54cd\u3002<\/p>\n

\u6b64\u5916\uff0cPCA\u5206\u6790\u663e\u793a\u4e86\u5973\u6027\u53c2\u4e0e\u8005\u5728\u751f\u916e\u996e\u98df\u540e\u7684\u53d8\u5316\u8f83\u5927\uff0c\u6697\u793a\u4e86\u6027\u522b\u5728\u5bf9\u996e\u98df\u54cd\u5e94\u4e2d\u53ef\u80fd\u5b58\u5728\u504f\u5dee\uff0c\u996e\u98df\u4e4b\u95f4\u86cb\u767d\u8d28\u4e30\u5ea6\u7684\u6027\u522b\u7279\u5f02\u5dee\u5f02\u5305\u62ec\u4e0e\u8461\u8404\u7cd6\u4ee3\u8c22\u548c\u514d\u75ab\u6709\u5173\u7684\u86cb\u767d\u8d28\u3002<\/p>\n<\/p>\n

\u56fe3 \u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\u663e\u793a\u751f\u916e\u996e\u98df\u540e\u9002\u5e94\u6027\u514d\u75ab\u7684\u4e0a\u8c03<\/p>\n

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