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\u77ed\u94fe\u8102\u80aa\u9178\uff08short-chainfatty acids\uff0cSCFAs\uff09\uff0c\u4e5f\u79f0\u6325\u53d1\u6027\u8102\u80aa\u9178\uff08Volatilefattyacids\uff0cVFAs\uff09\uff0c\u901a\u5e38\u628a\u78b3\u539f\u5b50\u6570\u4e3a1-6\u7684\u6709\u673a\u8102\u80aa\u9178\u79f0\u4e3a\u77ed\u94fe\u8102\u80aa\u9178\u3002\u4e3b\u8981\u5305\u62ec\u4e59\u9178\u3001\u4e19\u9178\u3001\u5f02\u4e01\u9178\u3001\u4e01\u9178\u3001\u5f02\u620a\u9178\u3001\u620a\u9178\u3001\u5df1\u9178\u3002SCFAs\u662f\u80a0\u9053\u83cc\u7fa4\u7684\u4ee3\u8c22\u4ea7\u7269\uff0c\u4eba\u4f53\u7ea690%SCFAs\u662f\u7531\u538c\u6c27\u5fae\u751f\u7269\u53d1\u9175\u96be\u6d88\u5316\u7684\u78b3\u6c34\u5316\u5408\u7269\u800c\u4ea7\u751f\uff0c\u4f59\u4e0b\u90e8\u5206\u5219\u662f\u7531\u996e\u98df\u6444\u5165\u548c\u86cb\u767d\u8d28\u7b49\u4ee3\u8c22\u4ea7\u751f\uff0c\u6b63\u5e38\u4eba\u4f53\u80a0\u9053\u6bcf\u65e5\u53ef\u4ea7\u751f\u7ea650~100mmol SCFAs\uff0c\u5728\u7ed3\u80a0\u4e2d\u4e59\u9178\u3001\u4e19\u9178\u3001\u4e01\u9178\u5360SCFAs\u603b\u91cf\u768495%\u5de6\u53f3\uff0c\u4e09\u8005\u6bd4\u4f8b\u5927\u81f4\u4e3a3:1:1\u3002<\/p>\n<\/p>\n

SCFAs\u7684\u4e3b\u8981\u4ea7\u751f\u90e8\u4f4d\u662f\u7ed3\u80a0\uff0c\u800c\u5b83\u7684\u79cd\u7c7b\u548c\u6570\u91cf\u5219\u4e3b\u8981\u53d6\u51b3\u4e8e\u80a0\u9053\u5185\u83cc\u7fa4\u7ec4\u6210\u3001\u6d88\u5316\u65f6\u95f4\uff08\u5728\u80a0\u9053\u8fd0\u8f6c\u7684\u65f6\u95f4\uff09\u3001\u5bbf\u4e3b-\u5fae\u751f\u7269\u4ee3\u8c22\u901a\u91cf\u4ee5\u53ca\u5bbf\u4e3b\u98df\u7269\u4e2d\u7684\u7ea4\u7ef4\u542b\u91cf\u3002\u4ea7\u77ed\u94fe\u8102\u80aa\u9178\u7684\u83cc\u7fa4\u4e3b\u8981\u6709\u62df\u6746\u83cc\u5c5e\u3001\u53cc\u6b67\u6746\u83cc\u5c5e\u3001\u771f\u6746\u83cc\u5c5e\u3001\u7624\u80c3\u7403\u83cc\u5c5e\u3001\u6d88\u5316\u94fe\u7403\u83cc\u5c5e\u3001\u68ad\u83cc\u5c5e\u3001\u94fe\u7403\u83cc\u5c5e\u3002<\/p>\n<\/p>\n

\u80a0\u9053\u83cc\u7fa4\u4ea7\u751f\u7684SCFAs\u53ef\u76f4\u63a5\u8c03\u8282\u5bbf\u4e3b\u5065\u5eb7\uff0cSCFAs\u53ef\u901a\u8fc7\u80fd\u91cf\u8c03\u8282\u3001\u80a0\u7c98\u819c\u5c4f\u969c\u3001\u514d\u75ab\u8c03\u8282\u3001\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u5206\u5316\u53ca\u51cb\u4ea1\u7b49\u65b9\u5f0f\u884c\u4f7f\u529f\u80fd\uff0c\u5f53\u673a\u4f53SCFAs\u7684\u542b\u91cf\u5931\u53bb\u5e73\u8861\uff0c\u5c31\u4f1a\u8868\u73b0\u51fa\u5404\u79cd\u75be\u75c5\u3002<\/p>\n

1.\u795e\u7ecf\u6027\u75be\u75c5<\/p>\n

SCFAs\u53ef\u4ee5\u8c03\u8282\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u6210\u719f\u53ca\u529f\u80fd\uff0c\u901a\u8fc7\u8111\u80a0-\u8f74\u5f71\u54cd\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u5982\u5e15\u91d1\u68ee\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\uff0cSCFAs\u53ef\u7f13\u89e3\u7126\u8651\u3002<\/p>\n

2.\u514d\u75ab\u7c7b\u75be\u75c5<\/p>\n

\u4e01\u9178\u53ef\u8c03\u8282\u5148\u5929\u6027\u548c\u9002\u5e94\u6027\u514d\u75ab\u7ec6\u80de\u7684\u4ea7\u751f\uff0c\u6d41\u901a\u548c\u529f\u80fd\u3002<\/p>\n

3.\u80bf\u7624\u75be\u75c5<\/p>\n

\u4e01\u9178\u80fd\u6291\u5236\u67d0\u4e9b\u80bf\u7624\u7ec6\u80de\u589e\u6b96\uff0c\u5e76\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u5206\u5316\u548c\u51cb\u4ea1\uff0c\u53ef\u5e94\u7528\u5230\u7ed3\u80a0\u80bf\u7624\u7684\u6cbb\u7597\u4e0a<\/p>\n

4.\u5fc3\u8111\u8840\u7ba1<\/p>\n

\u4e19\u9178\u53ef\u51cf\u8f7b\u8840\u7ba1\u708e\u75c7\u548c\u52a8\u8109\u7ca5\u6837\u786c\u5316<\/p>\n

5.\u80c3\u80a0\u9053\u75be\u75c5<\/p>\n

SCFAs\u53ef\u51cf\u5c11\u80a0\u9053\u7535\u89e3\u8d28\u76f8\u5173\u7684\u8179\u6cfb\uff0c\u4e01\u9178\u6cbb\u7597\u5148\u5929\u6027\u6c2f\u5316\u7269\u8179\u6cfb\uff0c\u9002\u91cfSCFAs\u53ef\u6291\u5236\u5927\u80a0\u57c3\u5e0c\u83cc\u5c5e\u3001\u5fd7\u8d3a\u83cc\u5c5e\u7b49\u81f4\u75c5\u83cc\u6216\u6761\u4ef6\u81f4\u75c5\u83cc\u751f\u957f\uff0c\u4fdd\u62a4\u80a0\u9053\uff0c\u9ad8\u6d53\u5ea6\u7684SCFAs\u635f\u5bb3\u80a0\u9ecf\u819c\uff0c\u53ef\u80fd\u53c2\u4e0e\u65b0\u751f\u513f\u574f\u6b7b\u6027\u5c0f\u80a0\u7ed3\u80a0\u708e\u7684\u53d1\u751f\uff1b<\/p>\n

6.\u4ee3\u8c22\u6027\u75be\u75c5<\/p>\n

SCFAs\u53ef\u4ee5\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u5206\u6ccc\uff0c\u964d\u4f4e\u8102\u80aa\u5806\u79ef\uff0c\u53ef\u6cbb\u7597\u80a5\u80d6\u4ee5\u53ca\u2161\u578b\u7cd6\u5c3f\u75c5\u3002<\/p>\n<\/p>\n

\u8fc8\u7ef4\u4ee3\u8c22\u57fa\u4e8eGC-MS\u6db2\u8d28\u8054\u7528\u5e73\u53f0\uff0c\u901a\u8fc7\u81ea\u5efa\u6570\u636e\u5e93\uff0c\u4e00\u6b21\u6027\u5bf97\u79cd\u77ed\u94fe\u8102\u80aa\u9178\u8fdb\u884c\u7edd\u5bf9\u5b9a\u91cf\u68c0\u6d4b\u3002\u91c7\u7528\u5185\u6807+\u5916\u6807\u53cc\u91cd\u9a8c\u8bc1\u7684\u7edd\u5bf9\u5b9a\u91cf\u65b9\u6cd5\uff0c\u8986\u76d6\u5e7f\u3001\u5b9a\u91cf\u51c6\uff0c\u9002\u5408\u5404\u7c7b\u77ed\u94fe\u8102\u80aa\u9178\u76f8\u5173\u75be\u75c5\u4ee5\u53ca\u80a0\u9053\u5fae\u751f\u7269\u4e0e\u5bbf\u4e3b\u4e92\u4f5c\u7814\u7a76\u3002\u8fc8\u7ef4\u4ee3\u8c22\u77ed\u94fe\u8102\u80aa\u9178\u4ea7\u54c1\u5df2\u68c0\u6d4b\u6837\u672c3000+\uff0c\u5df2\u68c0\u6d4b\u6837\u672c\u79cd\u7c7b60+\uff0c\u9879\u76ee\u6587\u7ae0\u767b\u4e0aGastroenterology\uff08IF:22\uff09\u3001Naturecommunication\uff08IF:17.69\uff09\u3001MetabolismClinical and Experimental\uff08IF:13.934\uff09\u3001npjParkinsons Disease\uff08IF:9.304\uff09\u3001AppliedMicrobiology and Biotechnology\uff08IF:5.56\uff09\u7b49\u8457\u540d\u671f\u520a\u3002<\/p>\n<\/p>\n

\u53c2\u8003\u6587\u732e<\/p>\n

1.ZhangF, Wan Y, Zuo T.et al. Prolonged Impairment of Short-Chain Fatty Acidand L-Isoleucine Biosynthesis in Gut Microbiome in Patients WithCOVID-19. Gastroenterology. 2022 Feb;162(2):548-561.e4. doi:10.1053\/j.gastro.2021.10.013. Epub 2021 Oct 21. PMID: 34687739;PMCID: PMC8529231.<\/p>\n

2.Wang R, Yao L, Meng T.et al. Rhodomyrtus tomentosa (Ait.) Hassk fruitphenolic-rich extract mitigates intestinal barrier dysfunction andinflammation in mice. Food Chem. 2022 Nov 1;393:133438. doi:10.1016\/j.foodchem.2022.133438. Epub 2022 Jun 8. PMID: 35696951.<\/p>\n

3.Wu JT, Sun CL, Lai TT.et al. Oral short-chain fatty acidsadministration regulates innate anxiety in adult microbiome-depletedmice. Neuropharmacology. 2022 Aug 15;214:109140. doi:10.1016\/j.neuropharm.2022.109140. Epub 2022 May 22. PMID: 35613660.<\/p>\n

4.Lavelle A, Sokol H. Gut microbiota-derived metabolites as key actorsin inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2020Apr;17(4):223-237. doi: 10.1038\/s41575-019-0258-z. Epub 2020 Feb 19.PMID: 32076145.<\/p>\n<\/p>\n

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