{"id":60984,"date":"2025-11-27T05:10:08","date_gmt":"2025-11-27T05:10:08","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=60984"},"modified":"2025-11-27T05:10:08","modified_gmt":"2025-11-27T05:10:08","slug":"%e5%a4%9a%e5%9b%8a%e8%82%be%e7%9a%84%e8%af%8a%e6%96%ad%e5%8f%8a%e6%89%98%e4%bc%90%e6%99%ae%e5%9d%a6%e6%b2%bb%e7%96%97%e5%ae%9e%e6%93%8d","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=60984","title":{"rendered":"\u591a\u56ca\u80be\u7684\u8bca\u65ad\u53ca\u6258\u4f10\u666e\u5766\u6cbb\u7597\u5b9e\u64cd"},"content":{"rendered":"

\u5e38\u67d3\u8272\u4f53\u663e\u6027\u9057\u4f20\u6027\u591a\u56ca\u80be\uff08autosomal dominant polycystic kidney disease\uff0cADPKD\uff09\u662f\u6700\u5e38\u89c1\u7684\u5355\u57fa\u56e0\u9057\u4f20\u6027\u80be\u75c5\uff0c\u60a3\u75c5\u7387\u4e3a 1\/1 000\uff5e1\/400\uff0c\u4ee5\u53cc\u80be\u5e7f\u6cdb\u56ca\u80bf\u5f62\u6210\u5e76\u8fdb\u884c\u6027\u589e\u5927\u4e3a\u4e3b\u8981\u8868\u73b0\uff0c\u6700\u7ec8\u5bfc\u81f4\u80be\u8870\u7aed\u3002ADPKD \u662f\u4e00\u79cd\u7cfb\u7edf\u6027\u75be\u75c5\uff0c\u9664\u80be\u810f\u8868\u73b0\u5916\uff0c\u8fd8\u53ef\u4f34\u591a\u79cd\u80be\u5916\u8868\u73b0\uff0c\u5305\u62ec\u809d\u56ca\u80bf\u3001\u9885\u5185\u52a8\u8109\u7624\u3001\u5fc3\u810f\u74e3\u819c\u5f02\u5e38\u7b49\u3002<\/p>\n

\n

\u3010\u75c5\u56e0\u548c\u53d1\u75c5\u673a\u5236\u3011<\/h2>\n

1.\u2002 \u5206\u5b50\u9057\u4f20\u5b66\u673a\u5236  ADPKD \u591a\u7531\u4f4d\u4e8e\u67d3\u8272\u4f53 16p13.3 \u7684 PKD1\uff08\u5360\u53d1\u75c5\u4eba\u6570\u7684 85%\uff09\u548c\u4f4d\u4e8e\u67d3\u8272\u4f53 4q22-23 \u7684 PKD2 \u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u3002PKD1 \u548c PKD2 \u5206\u522b\u7f16\u7801\u591a\u56ca\u86cb\u767d-1\uff08ploycystin-1\uff0cPC1\uff09\u548c\u591a\u56ca\u86cb\u767d-2\uff08ploycystin-2\uff0cPC2\uff09\u3002PKD 1 \u548c PKD 2 \u662f\u6309\u7167\u53d1\u73b0\u7684\u5148\u540e\u987a\u5e8f\u547d\u540d\u7684\u3002\u5b83\u4eec\u7684\u57fa\u56e0\u7a81\u53d8\u53ef\u5bfc\u81f4\u80be\u5c0f\u7ba1\u6269\u5f20\u548c\u56ca\u80bf\u5f62\u6210\u3002\u5176\u4e2d PKD 1 \u7a81\u53d8\u5bfc\u81f4\u7684\u5e38\u67d3\u8272\u4f53\u663e\u6027\u591a\u56ca\u80be\u75c5\u60a3\u8005\u5360 80%, \u800c\u5176\u4f59\u5927\u591a\u4e3a PKD 2 \u7a81\u53d8\u6240\u81f4\u3002ADPKD \u4e2d\u8fd8\u6709\u4e00\u5c0f\u90e8\u5206\u60a3\u8005\uff0c\u57fa\u56e0\u7a81\u53d8\u4e0e PKD 1 \u548c PKD 2 \u65e0\u5173, \u53ef\u80fd\u4e0e\u5c1a\u672a\u660e\u786e\u7684\u7b2c 3 \u79cd PKD \u57fa\u56e0\u7a81\u53d8\u6709\u5173\u3002<\/p>\n

2.\u2002 \u7ea4\u6bdb\u81f4\u75c5\u5b66\u8bf4\u548c\u201c\u4e8c\u6b21\u6253\u51fb\u201d\u5b66\u8bf4 \u76ee\u524d\u8ba4\u4e3a ADPKD \u60a3\u8005\u80da\u80ce\u671f\u4ece\u7236\u6bcd\u9057\u4f20\u7684 PKD 1 \u53ca PKD 2 \u57fa\u56e0\u7a81\u53d8\u5e76\u4e0d\u8db3\u4ee5\u5f15\u8d77\u80be\u56ca\u80bf\u53d1\u751f\u3002PC1 \u548c PC2 \u86cb\u767d\u5747\u8868\u8fbe\u4e8e\u80be\u5c0f\u7ba1\u4e0a\u76ae\u7ec6\u80de\u521d\u7ea7\u7ea4\u6bdb\uff0c\u5b83\u4eec\u7684\u7ed3\u6784\u548c\u529f\u80fd\u5f02\u5e38\u5f15\u8d77\u5c0f\u7ba1\u4e0a\u76ae\u7ec6\u80de\u5f02\u5e38\u589e\u751f\u3001\u56ca\u8154\u5185\u6db2\u4f53\u79ef\u805a\u53ca\u7ec6\u80de\u5916\u57fa\u8d28\u91cd\u5efa\uff0c\u76f4\u81f3\u5c0f\u7ba1\u6269\u5f20\u548c\u56ca\u80bf\u5f62\u6210\u3002\u5728\u611f\u67d3\u3001\u4e2d\u6bd2\u7b49\u540e\u5929\u56e0\u7d20\u4f5c\u7528\u4e0b\uff0cPKD \u6742\u5408\u5b50\u6b63\u5e38\u7b49\u4f4d\u57fa\u56e0\u53d1\u751f\u4f53\u7ec6\u80de\u7a81\u53d8\uff0c\u5bfc\u81f4\u56ca\u80bf\u53d1\u751f\u548c\u8fdb\u5c55\uff0c\u88ab\u79f0\u4e3a\u201c\u4e8c\u6b21\u6253\u51fb\u201d\u5b66\u8bf4\u3002<\/p>\n

\n

\u3010\u75c5\u7406\u3011<\/h2>\n

\u53cc\u4fa7\u80be\u810f\u4f53\u79ef\u663e\u8457\u589e\u5927\uff0c\u53ef\u4e0d\u5bf9\u79f0\uff0c\u4e00\u4fa7\u80be\u810f\u8f83\u5bf9\u4fa7\u80be\u810f\u589e\u5927\u3002\u4ece\u76ae\u8d28\u5230\u9ad3\u8d28\u5145\u6ee1\u5927\u5c0f\u4e0d\u7b49\u7403\u5f62\u56ca\u80bf\u3002\u80be\u810f\u4f53\u79ef\u5927\u5c0f\u4e0e\u80be\u810f\u529f\u80fd\u53ca\u5e76\u53d1\u75c7\u663e\u8457\u76f8\u5173\u3002\u80be\u810f\u957f\u5f84>15 cm, \u6613\u53d1\u751f\u8840\u5c3f\u3001\u9ad8\u8840\u538b\u3002\u80be\u76cf\u3001\u80be\u76c2\u53d1\u80b2\u6b63\u5e38, \u4f46\u53d7\u56ca\u80bf\u538b\u8feb, \u53ef\u6269\u5f20\u6216\u53d8\u5f62\u3002\u663e\u5fae\u955c\u4e0b\u53ef\u89c1\u56ca\u80bf\u4e0e\u56ca\u80bf\u4e4b\u95f4\u6709\u591a\u5c11\u4e0d\u7b49\u7684\u6b63\u5e38\u80be\u7ec4\u7ec7\uff0c\u8fd9\u53ef\u4e0e\u56ca\u80bf\u6027\u80be\u53d1\u80b2\u4e0d\u826f\u9274\u522b\u3002\u53d7\u56ca\u80bf\u7684\u6324\u538b, \u53ef\u4ee5\u89c2\u5bdf\u5230\u80be\u5c0f\u7403\u786c\u5316\u3001\u5c0f\u7ba1\u840e\u7f29\u3001\u95f4\u8d28\u7ea4\u7ef4\u5316\u548c\u4e0a\u76ae\u589e\u751f\u3002\u80be\u529f\u80fd\u6b63\u5e38\u6216\u65e9\u671f\u80be\u8870\u7aed\u60a3\u8005\u7403\u5165\u5c0f\u52a8\u8109\u548c\u5c0f\u53f6\u95f4\u52a8\u8109\u5373\u53ef\u53d1\u751f\u786c\u5316\uff0c\u95f4\u8d28\u5de8\u566c\u7ec6\u80de\u548c\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u3002\u56ca\u80bf\u886c\u91cc\u4e0a\u76ae\u7ec6\u80de\u589e\u6b96\u53ca\u51cb\u4ea1\u5747\u589e\u52a0, \u8868\u73b0\u4e3a\u5206\u5316\u4e0d\u826f\u7684\u7ec6\u80de\u5f62\u6001<\/p>\n

\n

\u3010\u4e34\u5e8a\u8868\u73b0\u3011<\/h2>\n

ADPKD \u4e34\u5e8a\u8868\u73b0\u5dee\u5f02\u8f83\u5927\uff0c\u591a\u4e3a\u6210\u5e74\u53d1\u75c5\uff0c\u5e38\u7d2f\u53ca\u591a\u4e2a\u5668\u5b98\u3002<\/p>\n

\uff08\u4e00\uff09\u2002\u80be\u810f\u8868\u73b0<\/h2>\n

1.\u2002 \u80be\u56ca\u80bf  \u53cc\u80be\u5e7f\u6cdb\u56ca\u80bf\u5f62\u6210\uff0c\u968f\u75c5\u7a0b\u8fdb\u5c55\u4e0d\u65ad\u589e\u591a\u3001\u589e\u5927\u3002\u90e8\u5206\u75c5\u4eba\u51fa\u73b0\u8179\u90e8\u80bf\u5757\uff0c\u8d28\u786c\uff0c\u8868\u9762\u5448\u7ed3\u8282\u72b6\uff0c\u968f\u547c\u5438\u79fb\u52a8\u3002<\/p>\n

2.\u2002 \u7ed3\u77f3  \u7ea6 20% \u7684\u75c5\u4eba\u5408\u5e76\u80be\u7ed3\u77f3\uff0c\u5927\u591a\u4e3a\u5c3f\u9178\u548c\/\u6216\u8349\u9178\u9499\u7ed3\u77f3\u3002<\/p>\n

3.\u2002 \u611f\u67d3  \u662f\u75c5\u4eba\u53d1\u70ed\u7684\u9996\u8981\u539f\u56e0\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u8180\u80f1\u708e\u3001\u80be\u76c2\u80be\u708e\u3001\u56ca\u80bf\u611f\u67d3\u4ee5\u53ca\u80be\u5468\u8113\u80bf\u3002<\/p>\n

4.\u2002 \u56ca\u80bf\u51fa\u8840\u548c\u8089\u773c\u8840\u5c3f  \u7531\u56ca\u58c1\u8840\u7ba1\u7834\u88c2\u3001\u7ed3\u77f3\u3001\u611f\u67d3\u6216\u764c\u53d8\u5f15\u8d77\u3002\u7ea6 40% \u7684\u75c5\u4eba\u5728\u75c5\u7a0b\u4e2d\u51fa\u73b0\u7531\u56ca\u58c1\u8840\u7ba1\u7834\u88c2\u5f15\u8d77\u7684\u8089\u773c\u8840\u5c3f\uff0c\u5e76\u53cd\u590d\u53d1\u4f5c\u3002<\/p>\n

5.\u2002 \u75bc\u75db  \u8170\u8179\u90e8\u75bc\u75db\u89c1\u4e8e\u7ea6 60% \u7684\u75c5\u4eba\uff0c\u662f\u6700\u5e38\u89c1\u7684\u65e9\u671f\u75c7\u72b6\u4e4b\u4e00\u3002\u6025\u6027\u75bc\u75db\u53ef\u7531\u80be\u56ca\u80bf\u7834\u88c2\u51fa\u8840\u3001\u5c3f\u8def\u6897\u963b\u6216\u5408\u5e76\u611f\u67d3\u5f15\u8d77\uff0c\u6162\u6027\u75bc\u75db\u591a\u7531\u589e\u5927\u7684\u80be\u810f\u6216\u56ca\u80bf\u7275\u62c9\u5305\u819c\u3001\u80be\u8482\u6216\u538b\u8feb\u90bb\u8fd1\u7ec4\u7ec7\u6240\u81f4\u3002<\/p>\n

6.\u2002 \u9ad8\u8840\u538b  \u662f\u6700\u5e38\u89c1\u7684\u65e9\u671f\u8868\u73b0\u4e4b\u4e00\uff0c\u89c1\u4e8e\u7ea6 30% \u7684\u513f\u7ae5\u75c5\u4eba\u3001\u7ea6 60% \u5408\u5e76\u80be\u8870\u7aed\u7684\u75c5\u4eba\uff0c\u5728\u7ec8\u672b\u671f\u80be\u75c5\u75c5\u4eba\u4e2d\u9ad8\u8fbe 80%\u3002<\/p>\n

7.\u2002 \u8d2b\u8840  \u4e0e\u5176\u4ed6\u75c5\u56e0\u5f15\u8d77\u7684\u80be\u8870\u7aed\u75c5\u4eba\u76f8\u6bd4\uff0cADPKD \u75c5\u4eba\u7684\u8d2b\u8840\u51fa\u73b0\u665a\u4e14\u7a0b\u5ea6\u8f7b\u3002<\/p>\n

8.\u2002 \u86cb\u767d\u5c3f  \u4e00\u822c\u4e3a\u6301\u7eed\u6027\u86cb\u767d\u5c3f\uff0c\u5b9a\u91cf\u591a\uff1c1g\/24h\uff0c\u662f\u4fc3\u8fdb\u80be\u529f\u80fd\u6076\u5316\u7684\u91cd\u8981\u5371\u9669\u56e0\u7d20\u3002<\/p>\n

9.\u2002 \u6162\u6027\u80be\u8870\u7aed  60 \u5c81\u4ee5\u4e0a\u7684\u75c5\u4eba\u7ea6 50% \u8fdb\u5165\u7ec8\u672b\u671f\u80be\u75c5\u3002<\/p>\n

\uff08\u4e8c\uff09\u2002\u80be\u5916\u8868\u73b0<\/h2>\n

1.\u2002 \u56ca\u6027\u75c5\u53d8  \u53ef\u7d2f\u53ca\u809d\u3001\u80f0\u3001\u813e\u3001\u5375\u5de2\u3001\u86db\u7f51\u819c\u53ca\u677e\u679c\u4f53\u7b49\u3002\u5176\u4e2d\u809d\u56ca\u80bf\u53d1\u751f\u7387\u6700\u9ad8\uff0c\u4f46\u809d\u529f\u80fd\u5f02\u5e38\u5c11\u89c1\u3002<\/p>\n

2.\u2002 \u975e\u56ca\u6027\u75c5\u53d8  \u5305\u62ec\u5fc3\u810f\u74e3\u819c\u5f02\u5e38\u3001\u7ed3\u80a0\u61a9\u5ba4\u3001\u9885\u5185\u52a8\u8109\u7624\u548c\u8179\u58c1\u759d\u7b49\u3002\u9885\u5185\u52a8\u8109\u7624\u662f\u6700\u4e3b\u8981\u7684\u65e9\u671f\u6b7b\u4ea1\u539f\u56e0\uff0c\u5c11\u6570\u75c5\u4eba\u5b58\u5728\u8840\u7ba1\u75c9\u631b\u6027\u5934\u75db\u3002\u7ea6 30% \u7684\u75c5\u4eba\u53ef\u53d1\u751f\u4e8c\u5c16\u74e3\u8131\u5782\u3002<\/p>\n

\n

\u3010\u8bca\u65ad\u3011<\/h2>\n

ADPKD \u8bca\u65ad\u4e3b\u8981\u4f9d\u636e\u5bb6\u65cf\u53f2\u3001\u4e34\u5e8a\u8868\u73b0\u3001\u5f71\u50cf\u5b66\u68c0\u67e5\u548c\u57fa\u56e0\u68c0\u6d4b\u3002<\/p>\n

\uff08\u4e00\uff09\u2002\u4e34\u5e8a\u8bca\u65ad\u6807\u51c6<\/h2>\n

ADPKD \u8bca\u65ad\u6807\u51c6\u5206\u4e3a\u4e3b\u8981\u8bca\u65ad\u6807\u51c6\u548c\u6b21\u8981\u8bca\u65ad\u6807\u51c6\uff0c\u89c1\u8868 5-8-1\uff0c\u53ea\u8981\u65f6\u7b26\u5408\u4e3b\u8981\u8bca\u65ad\u6807\u51c6\u548c\u4efb\u610f\u4e00\u9879\u6b21\u8981\u8bca\u65ad\u6807\u51c6\u5373\u53ef\u786e\u8bca\u3002<\/p>\n

\uff08\u4e8c\uff09\u2002\u8bca\u65ad\u65b9\u6cd5<\/h2>\n

1.\u2002 \u5bb6\u65cf\u53f2  \u75c5\u4eba\u5e38\u6709\u660e\u786e\u7684\u5bb6\u65cf\u9057\u4f20\u53f2\uff0c\u5448\u5e38\u67d3\u8272\u4f53\u663e\u6027\u9057\u4f20\u7279\u5f81\uff0c\u5b50\u4ee3\u53d1\u75c5\u7387\u4e3a\u7ea6 50%\uff0c\u7537\u5973\u5747\u7b49\u3002<\/p>\n

2.\u2002 \u5f71\u50cf\u5b66\u68c0\u67e5 \u8d85\u58f0\u3001CT \u548c MRI \u5747\u53ef\u7528\u4e8e\u8bca\u65ad\u3002 \uff081\uff09\u8d85\u58f0\uff1a\u662f\u9996\u9009\u7684\u8bca\u65ad\u65b9\u6cd5\uff0c\u7ecf\u6d4e\u4e14\u5b89\u5168\uff0c\u5224\u65ad\u6807\u51c6\u89c1\u8868 5-8-2\u3002\u5f69\u8d85\u8868\u73b0\u4e3a\u80be\u5185\u6570\u4e2a\u5927\u5c0f\u4e0d\u7b49\u7684\u56ca\u80bf\uff0c\u56ca\u58c1\u95f4\u6709\u82b1\u8272\u8840\u6d41\u3002<\/p>\n

==\u8868 2 \u5e38\u67d3\u8272\u4f53\u663e\u6027\u591a\u56ca\u80be\u75c5\u7684\u8d85\u58f0\u8bca\u65ad\u6807\u51c6\u548c\u6392\u9664\u6807\u51c6==<\/p>\n

\u6807\u51c615~39 \u5c8140~59 \u5c81\u226560 \u5c81\u8bca\u65ad\u6807\u51c6<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5e38\u67d3\u8272\u4f53\u663e\u6027\u9057\u4f20\u6027\u591a\u56ca\u80be\uff08autosomal dominant polycyst … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-60984","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/60984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=60984"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/60984\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=60984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=60984"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=60984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}