{"id":60435,"date":"2025-11-16T05:11:09","date_gmt":"2025-11-16T05:11:09","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=60435"},"modified":"2025-11-16T05:11:09","modified_gmt":"2025-11-16T05:11:09","slug":"%e3%80%90%e4%b8%ad%e5%9b%bd%e8%82%a0%e9%81%93%e5%be%ae%e7%94%9f%e6%80%81%e4%b8%93%e9%a2%98%e3%80%91%e8%82%a0%e9%81%93%e8%8f%8c%e7%be%a4%e5%9c%a8%e7%97%9b%e9%a3%8e%e7%97%85%e5%8f%98%e8%bf%87%e7%a8%8b","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=60435","title":{"rendered":"\u3010\u4e2d\u56fd\u80a0\u9053\u5fae\u751f\u6001\u4e13\u9898\u3011\u80a0\u9053\u83cc\u7fa4\u5728\u75db\u98ce\u75c5\u53d8\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u53ca\u6cbb\u7597\u7814\u7a76\u53ca\u6210\u4eba\u75db\u98ce\u98df\u517b\u6307\u5357\uff082024\u5e74\uff09\u2014\u2014\u4e2d\u56fd\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a"},"content":{"rendered":"<\/p>\n

    \u80a0\u9053\u662f\u4eba\u4f53\u6700\u5927\u7684\u514d\u75ab\u5668\u5b98\uff0c\u80a0\u9053\u5185\u5b9a\u690d\u7684\u5404\u80a0\u9053\u83cc\u7fa4\u5f7c\u6b64\u5236\u8861\uff0c\u76f8\u4f9d\u76f8\u8f85\uff0c\u4e0e\u5bbf\u4e3b\u6784\u6210\u4e92\u5229\u5171\u751f\u7684\u5173\u7cfb\uff0c\u5176\u6570\u91cf\u53ca\u79cd\u7c7b\u6539\u53d8\u53ef\u9020\u6210\u80a0\u9053\u5fae\u751f\u6001\u5931\u8861\uff0c\u5e76\u901a\u8fc7\u514d\u75ab\u8c03\u8282\u7684\u65b9\u5f0f\u5f71\u54cd\u673a\u4f53\u514d\u75ab\u529f\u80fd\uff0c\u8fdb\u800c\u5f71\u54cd\u75be\u75c5\u8fdb\u5c55\u3002\u76ee\u524d\u7814\u7a76\u53d1\u73b0\uff0c\u80a0\u9053\u5fae\u751f\u6001\u4e0e\u98ce\u6e7f\u514d\u75ab\u6027\u75be\u75c5\u5982\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u3001\u75db\u98ce\u6027\u5173\u8282\u708e\u3001\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7b49\u5bc6\u5207\u76f8\u5173\uff0c\u800c\u4ee5\u80a0\u9053\u83cc\u7fa4\u4f5c\u4e3a\u5207\u5165\u70b9\u63a2\u7d22\u75db\u98ce\u7684\u53d1\u75c5\u673a\u5236\u6210\u4e3a\u65b0\u7684\u7814\u7a76\u70ed\u70b9\u3002\u672c\u6587\u4ece\u80a0\u9053\u5fae\u751f\u6001\u7684\u7ec4\u6210\u53ca\u529f\u80fd\uff0c\u75db\u98ce\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u7684\u7ed3\u6784\u7279\u70b9\uff0c\u80a0\u9053\u83cc\u7fa4\u5728\u75db\u98ce\u53d1\u75c5\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff0c\u4ee5\u53ca\u76ca\u751f\u83cc\u3001\u4e2d\u836f\u548c\u7caa\u4fbf\u5fae\u751f\u7269\u79fb\u690d\u6cbb\u7597\u7b49\u65b9\u9762\u8fdb\u884c\u7efc\u8ff0\uff0c\u65e8\u5728\u4e3a\u75db\u98ce\u7684\u9632\u6cbb\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u548c\u65b9\u5411\u3002<\/p>\n<\/p>\n<\/p>\n<\/p>\n<\/p>\n<\/p>\n<\/p>\n

\u75db\u98ce\u662f\u4e00\u79cd\u7531\u4e8e\u560c\u5464\u4ee3\u8c22\u7d0a\u4e71\u3001\u5c3f\u9178\u6392\u6cc4\u51cf\u5c11\u6216\u4ea7\u751f\u8fc7\u591a\u5bfc\u81f4\u4f53\u5185\u8840\u5c3f\u9178\u6c34\u5e73\u5347\u9ad8\uff0c\u5c3f\u9178\u7ed3\u6676\u5728\u5173\u8282\u53ca\u5176\u4ed6\u7ed3\u7f14\u7ec4\u7ec7\u4e2d\u6c89\u79ef\u6240\u5f15\u8d77\u7684\u708e\u6027\u75be\u75c5\uff0c\u4ee5\u5173\u8282\u7ea2\u80bf\u3001\u75bc\u75db\u4e3a\u5178\u578b\u4e34\u5e8a\u8868\u73b0\uff0c\u591a\u5728\u591c\u95f4\u7a81\u7136\u53d1\u4f5c\uff0c\u5e76\u968f\u7740\u75be\u75c5\u7684\u8fdb\u5c55\u5448\u9010\u6e10\u52a0\u91cd\u7684\u8d8b\u52bf\uff0c\u4e0d\u4ec5\u4f1a\u9020\u6210\u5173\u8282\u7578\u5f62\uff0c\u4e14\u53ef\u7d2f\u53ca\u80be\u810f\u3001\u5f15\u53d1\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7b49\uff0c\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u75db\u98ce\u7684\u53d1\u751f\u53d1\u5c55\u4e0e\u4f53\u5185\u8840\u5c3f\u9178\u6c34\u5e73\u76f4\u63a5\u76f8\u5173\uff0c\u800c\u5c3f\u9178\u662f\u560c\u5464\u5316\u5408\u7269\u7684\u6700\u7ec8\u4ee3\u8c22\u4ea7\u7269\uff0c\u56e0\u6b64\uff0c\u8c03\u8282\u560c\u5464\u4ee3\u8c22\u5bf9\u4e8e\u75db\u98ce\u7684\u53d1\u75c5\u53ca\u6cbb\u7597\u81f3\u5173\u91cd\u8981\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u4f53\u5185\u560c\u5464\u5305\u62ec\u5916\u6e90\u6027\u548c\u5185\u6e90\u6027\u4e24\u79cd\uff0c\u524d\u8005\u7531\u4f53\u5185\u5408\u6210\uff0c\u540e\u8005\u5219\u4e3b\u8981\u6765\u6e90\u4e8e\u6444\u53d6\u7684\u98df\u7269\uff0c\u5177\u6709\u53ef\u63a7\u6027\uff0c\u56e0\u6b64\u5408\u7406\u8c03\u6574\u996e\u98df\u7ed3\u6784\u4ee5\u51cf\u5c11\u5916\u6e90\u6027\u560c\u5464\u7684\u6444\u5165\u662f\u76ee\u524d\u4e34\u5e8a\u4e0a\u63a7\u5236\u75db\u98ce\u6025\u6027\u53d1\u4f5c\u7684\u6709\u6548\u624b\u6bb5\u3002\u80a0\u9053\u4f5c\u4e3a\u6d88\u5316\u4e0e\u5438\u6536\u98df\u7269\u7684\u91cd\u8981\u5668\u5b98\uff0c\u4e3b\u8981\u529f\u80fd\u4e3a\u80a0\u9053\u83cc\u7fa4\u5c06\u98df\u7269\u5206\u89e3\u6210\u5355\u7cd6\u540e\u518d\u7531\u5c0f\u80a0\u4e0a\u76ae\u7ec6\u80de\u5438\u6536\u5165\u8840\u3002\u82e5\u80a0\u9053\u5fae\u73af\u5883\u53d1\u751f\u7d0a\u4e71\uff0c\u80a0\u9053\u83cc\u7fa4\u5c06\u76f4\u63a5\u8fc1\u79fb\u81f3\u80a0\u5916\u7ec4\u7ec7\uff0c\u4ea7\u751f\u5c0f\u5206\u5b50\u5e76\u8fdb\u5165\u8840\u6db2\u5faa\u73af\uff0c\u6700\u7ec8\u901a\u8fc7\u80a0\u9053Toll\u6837\u53d7\u4f53\u5bfc\u81f4\u98ce\u6e7f\u514d\u75ab\u6027\u75be\u75c5\u7684\u53d1\u751f\u3002\u56e0\u6b64\uff0c\u80a0\u9053\u83cc\u7fa4\u901a\u8fc7\u53c2\u4e0e\u560c\u5464\u4ee3\u8c22\u9176\u7684\u5408\u6210\u4ee5\u53ca\u708e\u6027\u56e0\u5b50\u7684\u91ca\u653e\uff0c\u5728\u75db\u98ce\u7684\u53d1\u751f\u53d1\u5c55\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\u3002\u6709\u7814\u7a76\u8bc1\u5b9e\uff0c\u4e0e\u5065\u5eb7\u4eba\u76f8\u6bd4\uff0c\u75db\u98ce\u60a3\u8005\u4f53\u5185\u80a0\u9053\u83cc\u7fa4\u7684\u4e30\u5ea6\u660e\u663e\u964d\u4f4e\u3002\u672c\u6587\u4ece\u80a0\u9053\u5fae\u751f\u6001\u7684\u7ec4\u6210\u53ca\u529f\u80fd\uff0c\u75db\u98ce\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u7684\u7ed3\u6784\u7279\u70b9\uff0c\u80a0\u9053\u83cc\u7fa4\u5728\u75db\u98ce\u53d1\u75c5\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff0c\u4ee5\u53ca\u76ca\u751f\u83cc\u3001\u4e2d\u836f\u548c\u7caa\u4fbf\u5fae\u751f\u7269\u79fb\u690d\u6cbb\u7597\u7b49\u65b9\u9762\u5c55\u5f00\u7efc\u8ff0\uff0c\u4ee5\u671f\u4e3a\u75db\u98ce\u7684\u5fae\u751f\u6001\u7814\u7a76\u63d0\u4f9b\u65b0\u601d\u8def\u3002<\/p>\n

\u4e00\u3001\u80a0\u9053\u5fae\u751f\u6001\u7684\u7ec4\u6210\u53ca\u529f\u80fd<\/h2>\n

\u80a0\u9053\u83cc\u7fa4\u662f\u4e00\u7c7b\u5b9a\u690d\u4e8e\u4eba\u4f53\u80a0\u9053\u4e2d\u91cd\u8981\u4e14\u590d\u6742\u7684\u5fae\u751f\u6001\u7cfb\u7edf\uff0c\u7531\u539f\u6838\u5fae\u751f\u7269\u3001\u771f\u6838\u5fae\u751f\u7269\u53ca\u75c5\u6bd2\u7b49\u6784\u6210\uff0c\u88ab\u79f0\u4e3a\u201c\u4ee3\u8c22\u5668\u5b98\u201d\u3002\u76ee\u524d\u53d1\u73b0\uff0c\u5065\u5eb7\u4eba\u4f53\u5185\u7ea6\u670910\u4e07\u4ebf\u4e2a\u80a0\u9053\u7ec6\u83cc\uff0c\u662f\u5bbf\u4e3b\u7ec6\u80de\u603b\u6570\u768410\u500d\uff0c\u6839\u636e\u4f5c\u7528\u673a\u5236\u7684\u4e0d\u540c\u53ef\u5206\u4e3a\u4e09\u79cd\uff1a(1)\u751f\u7406\u6027\u83cc\u7fa4\uff0c\u5982\u53cc\u6b67\u6746\u83cc\u4e0e\u4e73\u9178\u6746\u83cc\u7b49\u3002\u8be5\u83cc\u7fa4\u662f\u4e00\u79cd\u4f18\u52bf\u83cc\u7fa4\uff0c\u901a\u5e38\u4e0e\u5bbf\u4e3b\u6784\u6210\u4e92\u5229\u5171\u751f\u7684\u5173\u7cfb\uff0c\u53ef\u5bf9\u673a\u4f53\u4ea7\u751f\u6709\u76ca\u7684\u5f71\u54cd\u3002(2)\u673a\u4f1a\u81f4\u75c5\u83cc\uff0c\u5982\u80a0\u7403\u83cc\u3001\u80a0\u6746\u83cc\u7b49\u3002\u8be5\u83cc\u7fa4\u5e38\u9a7b\u4e8e\u4f53\u5185\uff0c\u5728\u6b63\u5e38\u60c5\u51b5\u4e0b\u65e0\u5bb3\uff0c\u4f46\u5728\u80a0\u9053\u5fae\u751f\u6001\u5931\u8861\u65f6\u53ef\u81f4\u75c5\u3002(3)\u8fc7\u8def\u83cc\uff0c\u5982\u5047\u5355\u80de\u83cc\u3001\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u7b49\u3002\u8be5\u83cc\u7fa4\u77ed\u6682\u505c\u7559\u4e8e\u4f53\u5185\uff0c\u5728\u80a0\u9053\u5fae\u751f\u6001\u53d1\u751f\u7d0a\u4e71\u65f6\u53ef\u5927\u91cf\u7e41\u6b96\u4ece\u800c\u5f15\u53d1\u75be\u75c5\u3002\u751f\u7406\u6027\u83cc\u7fa4\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u4e0d\u4ec5\u53c2\u4e0e\u7ef4\u751f\u7d20K\u3001\u53f6\u9178\u3001\u751f\u7269\u7d20\u7b49\u7684\u5408\u6210\uff0c\u8fd8\u80fd\u4fc3\u8fdb\u9499\u3001\u94c1\u7b49\u8425\u517b\u7269\u8d28\u7684\u5438\u6536\uff0c\u53ef\u663e\u8457\u589e\u5f3a\u5bbf\u4e3b\u7684\u514d\u75ab\u53ca\u4ee3\u8c22\u80fd\u529b\uff0c\u5728\u6d88\u5316\u4e0e\u5438\u6536\u98df\u7269\u65b9\u9762\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\u3002\u82e5\u5728\u996e\u98df\u3001\u73af\u5883\u4ee5\u53ca\u836f\u7269\u7b49\u56e0\u7d20\u7684\u4f5c\u7528\u4e0b\uff0c\u80a0\u9053\u7a33\u6001\u5931\u8861\uff0c\u673a\u4f1a\u81f4\u75c5\u83cc\u53ca\u8fc7\u8def\u83cc\u5219\u901a\u8fc7\u6539\u53d8\u80a0\u9053\u901a\u900f\u6027\u3001\u5f71\u54cd\u80fd\u91cf\u7684\u5438\u6536\u3001\u5206\u6ccc\u77ed\u94fe\u8102\u80aa\u9178\u5e72\u9884\u8111-\u80a0\u8f74\u7b49\u9014\u5f84\u5bf9\u673a\u4f53\u5065\u5eb7\u4ea7\u751f\u8d1f\u9762\u7684\u5f71\u54cd\u3002Jackson\u7b49\u5bf9\u4eba\u7c7b38\u79cd\u5e38\u89c1\u75be\u75c5\u4ee5\u53ca51\u79cd\u836f\u7269\u4e0e\u80a0\u9053\u83cc\u7fa4\u7684\u5173\u7cfb\u8fdb\u884c\u5b8f\u57fa\u56e0\u7ec4\u5173\u8054\u5206\u6790\uff0c\u53d1\u73b0\u5305\u62ec\u9aa8\u5173\u8282\u708e\u3001\u708e\u75c7\u6027\u80a0\u75c5\u3001\u80c6\u77f3\u75c7\u7b49\u5728\u5185\u768417\u79cd\u75be\u75c5\u4e0e\u80a0\u9053\u83cc\u7fa4\u5bc6\u5207\u76f8\u5173\u3002Gilbert\u7b49\u5e94\u7528\u5b8f\u57fa\u56e0\u7ec4\u5173\u8054\u5206\u6790\u80a0\u9053\u83cc\u7fa4\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u4e0e\u4eba\u7c7b\u5e38\u89c1\u75be\u75c5\u7684\u5173\u7cfb\uff0c\u53d1\u73b0\u80a5\u80d6\u3001\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3001\u708e\u75c7\u6027\u80a0\u75c5\u7b49\u4e0e\u591a\u79cd\u80a0\u9053\u83cc\u7fa4\u5b58\u5728\u5bc6\u5207\u5173\u7cfb\u3002<\/p>\n

\u4e8c\u3001\u75db\u98ce\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u7684\u7ed3\u6784\u7279\u70b9<\/h2>\n

\u80a0\u9053\u5b8f\u57fa\u56e0\u7ec4\u4f5c\u4e3a\u8c03\u63a7\u4eba\u4f53\u5065\u5eb7\u7684\u91cd\u8981\u57fa\u56e0\u7ec4\uff0c\u5bf9\u673a\u4f53\u7684\u514d\u75ab\u4e0e\u4ee3\u8c22\u529f\u80fd\u5177\u6709\u91cd\u8981\u5f71\u54cd\uff0c\u5c24\u5176\u662f\u4e0e\u4ee3\u8c22\u6027\u75be\u75c5\u5173\u7cfb\u5bc6\u5207\u3002\u76ee\u524d\u591a\u9879\u7814\u7a76\u53d1\u73b0\uff0c\u75db\u98ce\u60a3\u8005\u4f53\u5185\u7684\u80a0\u9053\u83cc\u7fa4\u4e0e\u5065\u5eb7\u4eba\u7fa4\u5dee\u5f02\u663e\u8457\u3002\u4efb\u79d1\u96e8\u7b49\u7814\u7a76\u53d1\u73b0\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u4f53\u5185\u5b58\u5728\u80a0\u9053\u83cc\u7fa4\u5931\u8861\u7684\u60c5\u51b5\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u751f\u7406\u6027\u83cc\u7fa4\u6570\u91cf\u51cf\u5c11\uff0c\u800c\u80a0\u6746\u83cc\u3001\u603b\u9700\u538c\u6c27\u83cc\u7b49\u6570\u91cf\u660e\u663e\u589e\u591a\uff0c\u8868\u660e\u8840\u5c3f\u9178\u5347\u9ad8\u53ef\u80fd\u4e0e\u53cc\u6b67\u6746\u83cc\u3001\u4e73\u9178\u6746\u83cc\u7b49\u76ca\u751f\u83cc\u51cf\u5c11\u6709\u5173\u3002Guo\u7b49\u7814\u7a76\u53d1\u73b0\uff0c\u75db\u98ce\u60a3\u8005\u4f53\u5185\u7caa\u62df\u6746\u83cc\u548c\u89e3\u6728\u805a\u7cd6\u62df\u6746\u83cc\u6570\u91cf\u660e\u663e\u589e\u591a\uff0c\u800c\u53cc\u6b67\u6746\u83cc\u53ca\u67d4\u5ae9\u68ad\u83cc\u7fa4\u8f83\u4e3a\u7f3a\u4e4f\u3002Shao\u7b49\u7814\u7a76\u53d1\u73b0\uff0c\u5927\u591a\u6570\u75db\u98ce\u60a3\u8005\u4f53\u5185\u80a0\u9053\u83cc\u7fa4\u7684\u591a\u6837\u6027\u5448\u4e0b\u964d\u8d8b\u52bf\uff0c\u4ee5\u538c\u6c27\u83cc\u53ca\u62df\u6746\u83cc\u7b49\u673a\u4f1a\u81f4\u75c5\u83cc\u53d8\u5316\u4e3a\u4e3b\u3002\u6b64\u5916\uff0cXing\u4f7f\u7528\u53d8\u6027\u68af\u5ea6\u51dd\u80f6\u7535\u6cf3(denaturing gradient gelelectrophoresis\uff0cDGGE)\u5206\u522b\u83b7\u5f97\u5065\u5eb7\u4eba\u7fa4\u53ca\u539f\u53d1\u6027\u75db\u98ce\u60a3\u8005\u7684\u5206\u5b50\u6307\u7eb9\u56fe\u8c31\uff0c\u5bf9\u5176\u76f8\u4f3c\u6027\u53ca\u591a\u6837\u6027\u8fdb\u884c\u6bd4\u8f83\uff0c\u53d1\u73b0\u75db\u98ce\u60a3\u8005\u7684\u68ad\u72b6\u82bd\u5b62\u6746\u83cc\u6570\u91cf\u8f83\u5065\u5eb7\u4eba\u7fa4\u660e\u663e\u51cf\u5c11\u3002\u4e5f\u6709\u5b66\u8005\u4f7f\u75281H-NMR\u53caIllumina Miseq\u6280\u672f\u5bf9\u75db\u98ce\u60a3\u8005\u548c\u5065\u5eb7\u4eba\u7fa4\u7caa\u4fbf\u63d0\u53d6\u7269\u7684\u4ee3\u8c22\u8c31\u53ca\u5fae\u751f\u7269\u7fa4\u843d\u8fdb\u884c\u7814\u7a76\uff0c\u53d1\u73b0\u75db\u98ce\u60a3\u8005\u4f53\u5185\u538c\u6c27\u83cc\u79d1\u3001\u7c7b\u6746\u83cc\u53ca\u535f\u5549\u5355\u80de\u83cc\u79d1\u7b49\u673a\u4f1a\u81f4\u75c5\u83cc\u660e\u663e\u589e\u591a\u3002\u603b\u4e4b\uff0c\u75db\u98ce\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u5931\u8c03\u4e3b\u8981\u8868\u73b0\u4e3a\u6297\u708e\u6027\u56e0\u5b50\u4ea7\u751f\u83cc\u3001\u76ca\u751f\u83cc\u51cf\u5c11\uff0c\u4ee5\u53ca\u673a\u4f1a\u81f4\u75c5\u83cc\u589e\u591a\u4e24\u4e2a\u65b9\u9762\uff0c\u8fd9\u4e9b\u53d8\u5316\u53ef\u5f15\u8d77\u673a\u4f53\u560c\u5464\u4ee3\u8c22\u5931\u8c03\uff0c\u4ece\u800c\u4fc3\u4f7f\u8840\u5c3f\u9178\u5347\u9ad8\u5e76\u91ca\u653e\u5927\u91cf\u708e\u6027\u56e0\u5b50\uff0c\u6700\u7ec8\u8bf1\u53d1\u75db\u98ce\u7684\u53d1\u751f\u3002<\/p>\n

\u4e09\u3001\u80a0\u9053\u83cc\u7fa4\u5728\u75db\u98ce\u53d1\u75c5\u4e2d\u7684\u4f5c\u7528\u673a\u5236<\/h2>\n

3.1 \u80a0\u9053\u83cc\u7fa4\u5f71\u54cd\u5c3f\u9178\u3001\u560c\u5464\u7684\u751f\u6210\u53ca\u6392\u6cc4 \u560c\u5464\u5728\u4eba\u4f53\u5185\u4e3b\u8981\u4ee5\u560c\u5464\u6838\u82f7\u9178\u7684\u5f62\u5f0f\u5b58\u5728\uff0c\u53ef\u5728\u6c34\u89e3\u4f5c\u7528\u4e0b\u5f62\u6210\u817a\u560c\u5464\u548c\u9e1f\u560c\u5464\uff0c\u5e76\u7ecf\u8fc7\u8131\u6c28\u751f\u6210\u9ec4\u560c\u5464\uff0c\u6700\u540e\u7ecf\u8fc7\u6c27\u5316\u5f62\u6210\u5c3f\u9178\uff0c\u800c\u5c3f\u9178\u6c34\u5e73\u5347\u9ad8\u88ab\u8ba4\u4e3a\u662f\u75db\u98ce\u53d1\u4f5c\u7684\u6700\u76f4\u63a5\u539f\u56e0\u3002\u968f\u7740\u4eba\u4eec\u5bf9\u80a0\u9053\u83cc\u7fa4\u4e0e\u75db\u98ce\u8ba4\u8bc6\u7684\u4e0d\u65ad\u52a0\u6df1\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8bc1\u5b9e\u80a0\u9053\u83cc\u7fa4\u53ef\u901a\u8fc7\u4fc3\u8fdb\u5c3f\u9178\u5206\u89e3\u53ca\u6392\u6cc4\u6765\u5f71\u54cd\u75db\u98ce\u7684\u53d1\u4f5c\u3002<\/p>\n

\u5065\u5eb7\u4eba\u4f53\u5185\u7ea6\u67092\/3\u7684\u5c3f\u9178\u7ecf\u8fc7\u80be\u810f\u4ee3\u8c22\u540e\u968f\u5c3f\u6db2\u4e00\u8d77\u6392\u51fa\uff0c\u5269\u4f591\/3\u5219\u7ecf\u8fc7\u80a0\u9053\u6392\u51fa\u3002\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u7531\u80a0\u9053\u83cc\u7fa4\u5206\u6ccc\u7684\u4e73\u817a\u8010\u836f\u86cb\u767d(ATPbinding cassette subfamily G member 2\uff0cABCG2)\u3001\u6eb6\u8d28\u8f7d\u4f53\u5bb6\u65cf16\u6210\u54589(solute carrier family 16 member 9\uff0cSLC16A9)\u53ca\u6eb6\u8d28\u8f7d\u4f53\u5bb6\u65cf17\u6210\u54584(solute carrier family 17 member 4\uff0cSLC17A4)\u7b49\u5c3f\u9178\u8f6c\u8fd0\u86cb\u767d\u5c06\u5c3f\u9178\u4ece\u8840\u6db2\u4e2d\u8fd0\u8f93\u81f3\u80a0\u8154\uff0c\u7ecf\u80a0\u8154\u76f4\u63a5\u6392\u51fa\u4f53\u5916\u6216\u7531\u4e73\u6746\u83cc\u5c5e\u548c\u5047\u5355\u80de\u83cc\u5c5e\u7b49\u5206\u89e3\u3002\u67d0\u4e9b\u7531\u80a0\u9053\u83cc\u7fa4\u5206\u6ccc\u4ea7\u751f\u7684\u6d3b\u6027\u9176\u5728\u5c3f\u9178\u7684\u5206\u89e3\u53ca\u4ee3\u8c22\u4e2d\u4e5f\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u4e73\u9178\u6746\u83cc\u53ca\u5047\u5355\u80de\u83cc\u5c5e\u901a\u8fc7\u4ea7\u751f\u77ed\u94fe\u8102\u80aa\u9178\u800c\u4fc3\u8fdb\u80a0\u5185\u5c3f\u9178\u7684\u5206\u89e3\u53ca\u6392\u6cc4\uff0c\u5927\u80a0\u57c3\u5e0c\u83cc\u901a\u8fc7\u5206\u6ccc\u9ec4\u560c\u5464\u8131\u6c22\u9176\u53c2\u4e0e\u560c\u5464\u6c27\u5316\u4ee3\u8c22\u6765\u52a0\u5feb\u5c3f\u9178\u7684\u751f\u6210\u7b49\u3002\u56e0\u6b64\uff0c\u80a0\u9053\u83cc\u7fa4\u53d1\u751f\u7d0a\u4e71\u65f6\u53ef\u5bf9\u560c\u5464\u53ca\u5c3f\u9178\u7684\u4ee3\u8c22\u9020\u6210\u5f71\u54cd\uff0c\u5f15\u8d77\u5c3f\u9178\u751f\u6210\u8fc7\u591a\u6216\u6392\u6cc4\u51cf\u5c11\uff0c\u6700\u7ec8\u5bfc\u81f4\u75db\u98ce\u53d1\u4f5c\u3002Yu\u7b49\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\u5927\u9f20\u7684\u80a0\u9053\u83cc\u7fa4\u7ed3\u6784\u53d1\u751f\u4e86\u6539\u53d8\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u5177\u6709\u5438\u6536\u3001\u5206\u89e3\u560c\u5464\u53ca\u5c3f\u9178\u4f5c\u7528\u7684\u4e73\u6746\u83cc\u3001\u94fe\u7403\u83cc\u7b49\u83cc\u5c5e\u660e\u663e\u51cf\u5c11\uff0c\u800c\u53ef\u5c06\u560c\u5464\u8f6c\u53d8\u4e3a\u5c3f\u9178\u7684\u53d8\u5f62\u6746\u83cc\u660e\u663e\u589e\u591a\u3002\u53e6\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u77ed\u94fe\u8102\u80aa\u9178\u53ef\u901a\u8fc7\u8c03\u8282\u80a0\u9053\u6162\u6027\u708e\u75c7\u800c\u52a0\u5feb\u80a0\u9053\u4e0a\u76ae\u7ec6\u80de\u7684\u4fee\u590d\u53ca\u518d\u751f\uff0c\u4fc3\u4f7f\u80a0\u9053\u83cc\u7fa4\u5206\u89e3\u4ee3\u8c22\u51fa\u66f4\u591a\u7684\u5c3f\u9178\u8f6c\u8fd0\u86cb\u767d\uff0c\u4ee5\u52a0\u5feb\u5c3f\u9178\u7684\u6392\u6cc4\uff1b\u800c\u5f53ABCG2\u3001SLC16A9\u53caSLC17A4\u7b49\u5c3f\u9178\u8f6c\u8fd0\u86cb\u767d\u53d1\u751f\u7a81\u53d8\u65f6\uff0c\u53ef\u76f4\u63a5\u5bfc\u81f4\u5c3f\u9178\u6392\u6cc4\u969c\u788d\u3002Ichida\u7b49\u4e5f\u53d1\u73b0\uff0cABCG2\u5728\u56de\u80a0\u4e2d\u5448\u9ad8\u8868\u8fbe\u7684\u8d8b\u52bf\uff0c\u5f53\u5bcc\u542b\u560c\u5464\u53ca\u6838\u82f7\u9178\u7684\u98df\u7269\u8f6c\u8fd0\u81f3\u80a0\u9053\u65f6\uff0c\u5927\u80a0\u57c3\u5e0c\u83cc\u901a\u8fc7\u5206\u89e3\u4ee3\u8c22\u51fa\u9ec4\u560c\u5464\u8131\u6c22\u9176\u5c06\u98df\u7269\u8fdb\u4e00\u6b65\u8f6c\u5316\u6210\u5c3f\u9178\uff0c\u6b64\u65f6\u82e5\u963b\u65ad\u5c3f\u9178\u8fdb\u5165\u80a0\u9053\u5c06\u5f15\u8d77\u8840\u5c3f\u9178\u6d53\u5ea6\u5347\u9ad8\uff0c\u8868\u660e\u5fae\u751f\u7269\u7fa4\u7684\u6539\u53d8\u5bf9\u5c3f\u9178\u7684\u8c03\u63a7\u81f3\u5173\u91cd\u8981\uff0c\u5177\u4f53\u673a\u5236\u5982\u56fe1\u6240\u793a\u3002<\/p>\n

\u56fe1 \u80a0\u9053\u83cc\u7fa4\u5f71\u54cd\u5c3f\u9178\u3001\u560c\u5464\u7684\u751f\u6210\u53ca\u6392\u6cc4Fig.1 Intestinal flora affects the production and excretion of uric acid and purine<\/p>\n

AMP.\u78f7\u9178\u817a\u82f7\uff1bIMP.\u808c\u82f7\u9178<\/p>\n

3.2 \u9ad8\u560c\u5464\u3001\u679c\u7cd6\u996e\u98df\u7834\u574f\u80a0\u9053\u83cc\u7fa4\u7a33\u6001 80%\u7684\u5c3f\u9178\u7531\u5185\u6e90\u6027\u560c\u5464\u964d\u89e3\u800c\u6210\uff0c\u5269\u4f5920%\u5219\u7531\u98df\u7269\u7b49\u5916\u6e90\u6027\u560c\u5464\u4ea7\u751f\u3002\u76f8\u5173\u7814\u7a76\u53d1\u73b0\uff0c\u9ad8\u560c\u5464\u996e\u98df\u5982\u6d77\u9c9c\u3001\u52a8\u7269\u5185\u810f\u7b49\u53ef\u5bfc\u81f4\u5916\u5468\u8840\u4e2d\u8102\u591a\u7cd6\u53ca\u9ec4\u560c\u5464\u6c27\u5316\u9176\u7684\u8868\u8fbe\u6c34\u5e73\u589e\u9ad8\uff0c\u4ece\u800c\u8bf1\u53d1\u9ad8\u5c3f\u9178\u8840\u75c7\u3001\u75db\u98ce\u7b49\u3002\u679c\u7cd6\u4f5c\u4e3a\u5404\u79cd\u852c\u679c\u4e2d\u7684\u5929\u7136\u7cd6\u5206\uff0c\u901a\u5e38\u88ab\u7528\u4f5c\u98df\u54c1\u53ca\u996e\u6599\u7684\u542b\u7cd6\u6dfb\u52a0\u5242\u3002\u4e0d\u540c\u4e8e\u8461\u8404\u7cd6\u7684\u5206\u89e3\u4ee3\u8c22\uff0c\u679c\u7cd6\u4e0d\u53d7\u8d1f\u53cd\u9988\u8c03\u8282\u63a7\u5236\u3002\u8fc7\u591a\u6444\u5165\u679c\u7cd6\u540e\u7ec6\u80de\u5185\u78f7\u9178\u76d0\u53ca\u4e09\u78f7\u9178\u817a\u82f7\u7684\u8868\u8fbe\u660e\u663e\u53d7\u5230\u6291\u5236\uff0c\u6b64\u65f6\u78f7\u9178\u817a\u82f7\u8131\u6c28\u9176\u7684\u6d3b\u6027\u589e\u5f3a\uff0c\u8fdb\u4e00\u6b65\u50ac\u5316\u78f7\u9178\u817a\u82f7\u8f6c\u5316\u4e3a\u9ec4\u560c\u5464\uff0c\u5e76\u6700\u7ec8\u751f\u6210\u5c3f\u9178\uff0c\u76ee\u524d\u8fd9\u88ab\u8ba4\u4e3a\u662f\u5f15\u53d1\u4ee3\u8c22\u6027\u7efc\u5408\u5f81\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u56e0\u6b64\uff0c\u996e\u98df\u662f\u80c3\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u6539\u53d8\u7684\u91cd\u8981\u539f\u56e0\uff0c\u9ad8\u560c\u5464\u6216\u9ad8\u679c\u7cd6\u996e\u98df\u5df2\u88ab\u4f17\u591a\u7814\u7a76\u8bc1\u5b9e\u53ef\u4fc3\u4f7f\u80a0\u9053\u83cc\u7fa4\u7ed3\u6784\u53d1\u751f\u6539\u53d8\uff0c\u4ece\u800c\u9020\u6210\u4f53\u5185\u5c3f\u9178\u6c34\u5e73\u5347\u9ad8\u3002\u9ec4\u80dc\u7537\u7b49\u7814\u7a76\u53d1\u73b0\uff0c\u9ad8\u560c\u5464\u996e\u98df\u53ef\u5f15\u8d77\u53cc\u6b67\u6746\u83cc\u53ca\u4e73\u6746\u83cc\u6570\u91cf\u51cf\u5c11\uff0c\u4f7f\u80a0\u9053\u83cc\u7fa4\u7ed3\u6784\u53d1\u751f\u6539\u53d8\uff0c\u9020\u6210\u5916\u5468\u8840\u4e2d\u5185\u6bd2\u7d20\u53ca\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6c34\u5e73\u5347\u9ad8\uff0c\u4ece\u800c\u5bfc\u81f4\u9ad8\u5c3f\u9178\u8840\u75c7\u53ca\u75db\u98ce\u7684\u53d1\u751f\u3002\u9ad8\u679c\u7cd6\u996e\u98df\u53ef\u6253\u7834\u80a0\u9053\u83cc\u7fa4\u7684\u7a33\u6001\uff0c\u5bfc\u81f4\u673a\u4f53\u4ee3\u8c22\u5f02\u5e38\u3002\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u7ecf\u9ad8\u679c\u7cd6\u996e\u98df\u5582\u517b\u540e\uff0c\u5927\u9f20\u4f53\u5185\u4e3b\u8981\u6709\u4e09\u79cd\u83cc\u7fa4\u51fa\u73b0\u7d0a\u4e71\uff1a\u68ad\u6746\u83cc\u5c5e\u589e\u591a\uff0c\u62df\u6746\u83cc\u5c5e\u3001\u4e73\u6746\u83cc\u5c5e\u660e\u663e\u51cf\u5c11\uff1b\u800c\u7ecf\u53cc\u6b67\u6746\u83cc\u9972\u517b\u540e\uff0c\u5927\u9f20\u8840\u6d46\u4e2d\u8102\u591a\u7cd6\u3001\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(tumor necrosis factor\uff0cTNF)-\u03b1\u8868\u8fbe\u4e0b\u8c03\uff0c\u4e0a\u8ff0\u83cc\u5c5e\u7d0a\u4e71\u60c5\u51b5\u5f97\u5230\u6539\u5584\u3002Kaneko\u7b49\u6307\u51fa\uff0c\u5927\u91cf\u98df\u7528\u679c\u7cd6\u53ef\u6fc0\u6d3bNADPH\u6c27\u5316\u9176\uff0c\u8fdb\u4e00\u6b65\u963b\u6b62\u5c3f\u9178\u7ecf\u56de\u80a0\u6392\u51fa\uff0c\u4ece\u800c\u9020\u6210\u4f53\u5185\u8840\u5c3f\u9178\u6c34\u5e73\u589e\u9ad8\u3002\u6b64\u5916\uff0c\u679c\u7cd6\u7684\u9ad8\u6d88\u8017\u5728\u52a0\u5feb\u560c\u5464\u964d\u89e3\u7684\u540c\u65f6\uff0c\u8fd8\u53ef\u4fc3\u4f7f\u80a0\u9053\u8425\u517b\u4e0d\u826f\u53ca\u8102\u591a\u7cd6\u76f8\u5173\u708e\u75c7\u7684\u53d1\u751f\u3002\u603b\u4e4b\uff0c\u996e\u98df\u662f\u80c3\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u7684\u91cd\u8981\u5f71\u54cd\u56e0\u7d20\uff0c\u9488\u5bf9\u9ad8\u679c\u7cd6\u3001\u9ad8\u560c\u5464\u996e\u98df\u8bf1\u53d1\u80a0\u9053\u5fae\u751f\u6001\u5931\u8861\u7684\u673a\u5236\u4ee5\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\uff0c\u53ef\u80fd\u662f\u9632\u6cbb\u9ad8\u5c3f\u9178\u8840\u75c7\u53ca\u75db\u98ce\u7684\u6709\u6548\u624b\u6bb5(\u56fe2)\u3002<\/p>\n

\u56fe2 \u9ad8\u560c\u5464\u3001\u679c\u7cd6\u996e\u98df\u4e0e\u80a0\u9053\u83cc\u7fa4\u7684\u5173\u7cfbFig.2 Relationship of high purine and fructose diet to the intestinal flora<\/p>\n

AMP.\u78f7\u9178\u817a\u82f7<\/p>\n

3.3 \u80a0\u9053\u83cc\u7fa4\u7d0a\u4e71\u8bf1\u53d1\u673a\u4f53\u514d\u75ab\u708e\u75c7\u53cd\u5e94 \u75db\u98ce\u6025\u6027\u53d1\u4f5c\u662f\u4e00\u79cd\u65e9\u671f\u8bf1\u5bfc\u7684\u514d\u75ab\u5e94\u7b54\u53cd\u5e94\uff0c\u591a\u4f34\u6709\u7ec6\u80de\u56e0\u5b50\u523a\u6fc0\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u6570\u91cf\u589e\u591a\uff0c\u4e0e\u9ad8\u5c3f\u9178\u8840\u75c7\u76f4\u63a5\u76f8\u5173\u3002\u76ee\u524d\u7814\u7a76\u53d1\u73b0\uff0c\u7531\u5c3f\u9178\u751f\u6210\u7684\u5c3f\u9178\u94a0\u7ed3\u6676\u662f\u8bf1\u53d1\u3001\u652f\u6301\u53ca\u52a0\u91cd\u708e\u75c7\u53cd\u5e94\u7684\u5173\u952e\u4ecb\u8d28\uff0c\u5176\u80fd\u8bf1\u4f7f\u767d\u7ec6\u80de\u8d8b\u5316\u4ee5\u53ca\u708e\u6027\u7269\u8d28\u7684\u5927\u91cf\u91ca\u653e\uff0c\u6700\u7ec8\u5f15\u8d77\u75db\u98ce\u7684\u6025\u6027\u53d1\u4f5c\u3002\u5728\u8c03\u63a7\u4eba\u4f53\u5bf9\u5c3f\u9178\u5355\u94a0\u7ed3\u6676\u5f15\u8d77\u7684\u708e\u75c7\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u80a0\u9053\u83cc\u7fa4\u7d0a\u4e71\u5bfc\u81f4\u7684\u77ed\u94fe\u8102\u80aa\u9178\u53ca\u8102\u591a\u7cd6\u542b\u91cf\u6539\u53d8\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u8fd1\u5e74\u6765\u53d7\u5230\u4e86\u5e7f\u6cdb\u5173\u6ce8\u3002<\/p>\n

\u77ed\u94fe\u8102\u80aa\u9178\u4e3b\u8981\u5305\u62ec\u918b\u9178\u76d0\u3001\u4e19\u9178\u76d0\u53ca\u4e01\u9178\u76d0\u7b49\uff0c\u53ef\u8c03\u8282\u4f53\u6db2\u4ee3\u8c22\u3001\u589e\u5f3a\u80a0\u9053\u5c4f\u969c\u529f\u80fd\u4ee5\u53ca\u6291\u5236\u80a0\u9053\u708e\u75c7\u53cd\u5e94\uff0c\u5728\u7ef4\u6301\u673a\u4f53\u5065\u5eb7\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002Cleophas\u7b49\u8bc1\u5b9e\uff0c\u4e01\u9178\u76d0\u80fd\u591f\u901a\u8fc7\u6291\u5236\u7ec4\u86cb\u767d\u8131\u4e59\u9170\u57fa\u9176\u7684\u8868\u8fbe\u800c\u53d1\u6325\u51cf\u5c11\u767d\u7ec6\u80de\u4ecb\u7d20(interleukin\uff0cIL)-1\u03b2\u5408\u6210\u53ca\u91ca\u653e\u7684\u4f5c\u7528\uff0c\u53ef\u6709\u6548\u51cf\u8f7b\u708e\u75c7\u53cd\u5e94\u3002\u53e6\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u4e01\u9178\u76d0\u53ef\u8c03\u63a7G\u86cb\u767d\u5076\u8054\u53d7\u4f53\u3001\u6838\u8f6c\u5f55\u56e0\u5b50\u03baB(nuclear factor kappa-B\uff0cNF-\u03baB)\u3001\u916a\u6c28\u9178\u6fc0\u9176\/\u4fe1\u53f7\u8f6c\u5bfc\u53ca\u8f6c\u5f55\u6fc0\u6d3b\u56e0\u5b50(Janus kinase\/signal transducers and activators of transcription\uff0cJAK\/STAT)\u7b49\u708e\u75c7\u4fe1\u53f7\u901a\u8def\u7684\u6d3b\u6027\uff0c\u4ece\u800c\u6291\u5236\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u91ca\u653e\uff0c\u800c\u5f53\u80a0\u9053\u83cc\u7fa4\u7d0a\u4e71\u9020\u6210\u4e01\u9178\u76d0\u51cf\u5c11\u65f6\uff0c\u53ef\u663e\u8457\u52a0\u5feb\u708e\u75c7\u53cd\u5e94\u7684\u53d1\u751f\u3002\u5f20\u548c\u5e73\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u75db\u98ce\u60a3\u8005\u4f53\u5185\u4e01\u9178\u76d0\u7684\u5408\u6210\u660e\u663e\u51cf\u5c11\uff0c\u800c\u670d\u7528\u76ca\u751f\u83cc\u6539\u5584\u80a0\u9053\u83cc\u7fa4\u4e0d\u4ec5\u80fd\u4fc3\u8fdb\u5c3f\u9178\u7684\u6392\u6cc4\uff0c\u8fd8\u80fd\u591f\u63d0\u5347\u80a0\u9053\u9ecf\u819c\u62b5\u6297\u611f\u67d3\u7684\u80fd\u529b\uff0c\u6709\u6548\u4fc3\u8fdb\u4e01\u9178\u76d0\u7684\u751f\u6210\uff0c\u6291\u5236\u7ec4\u86cb\u767d\u8131\u4e59\u9170\u57fa\u9176\u7684\u6d3b\u6027\uff0c\u4ece\u800c\u51cf\u5c11\u75db\u98ce\u7684\u6025\u6027\u53d1\u4f5c\u3002<\/p>\n

\u8102\u591a\u7cd6\u7531\u8102\u8d28\u548c\u591a\u7cd6\u6784\u6210\uff0c\u662f\u80a0\u9053\u83cc\u7fa4\u4e2d\u9769\u5170\u9634\u6027\u83cc\u7ec6\u80de\u58c1\u7684\u7ec4\u6210\u6210\u5206\u3002\u80a0\u9053\u5fae\u73af\u5883\u7d0a\u4e71\u53ef\u660e\u663e\u6291\u5236\u9769\u5170\u9634\u6027\u83cc\u7684\u6d3b\u6027\uff0c\u6b64\u65f6\u8102\u591a\u7cd6\u5206\u6ccc\u589e\u591a\u53ef\u4fc3\u4f7f\u673a\u4f53\u4ea7\u751f\u5927\u91cf\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u5e76\u589e\u52a0\u80a0\u58c1\u7684\u901a\u900f\u6027\uff0c\u8bf1\u53d1\u4f4e\u5ea6\u6162\u6027\u708e\u75c7\uff0c\u5373\u201c\u4ee3\u8c22\u6027\u5185\u6bd2\u7d20\u8840\u75c7\u201d\u3002\u76ee\u524d\u7814\u7a76\u53d1\u73b0\uff0c\u8102\u591a\u7cd6\u4e0e\u4ee3\u8c22\u6027\u7efc\u5408\u5f81\u3001\u80a5\u80d6\u7b49\u591a\u79cd\u75be\u75c5\u5bc6\u5207\u76f8\u5173\u3002Xu\u7b49\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u53d8\u5f62\u83cc\u95e8\u7684\u4f5c\u7528\u4e0b\uff0c\u75db\u98ce\u5927\u9f20\u80a0\u9053\u8425\u517b\u6761\u4ef6\u53d8\u5dee\uff0c\u4e14\u80a0\u4e0a\u76ae\u53ca\u80be\u810f\u5185\u76ae\u7684\u901a\u900f\u6027\u663e\u8457\u589e\u52a0\uff0c\u8fd9\u53ef\u4fc3\u4f7f\u8102\u591a\u7cd6\u8fdb\u5165\u8840\u6db2\u5faa\u73af\uff0c\u663e\u8457\u52a0\u5267\u75db\u98ce\u7684\u53d1\u4f5c\u3002\u53e6\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u4e0e\u6b63\u5e38\u5c0f\u9f20\u76f8\u6bd4\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\u5c0f\u9f20\u4f53\u5185\u53cc\u6b67\u6746\u83cc\u3001\u4e73\u6746\u83cc\u7b49\u660e\u663e\u51cf\u5c11\uff0c\u800c\u8840\u6e05\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6d3b\u6027\u53ca\u8102\u591a\u7cd6\u6c34\u5e73\u5347\u9ad8\uff0c\u5728\u4f7f\u7528\u76ca\u751f\u83cc\u6cbb\u7597\u540e\uff0c\u80a0\u9053\u5185\u6709\u76ca\u83cc\u589e\u591a\uff0c\u8840\u6e05\u8102\u591a\u7cd6\u3001\u9ec4\u560c\u5464\u6c27\u5316\u9176\u7b49\u7684\u8868\u8fbe\u6c34\u5e73\u660e\u663e\u4e0b\u964d\u3002<\/p>\n

\u56fe3 \u80a0\u9053\u83cc\u7fa4\u4e0e\u673a\u4f53\u514d\u75ab\u708e\u75c7\u53cd\u5e94\u7684\u5173\u7cfbFig.3 Relationship between intestinal flora and immune inflammatory response of the body<\/p>\n

3.4 \u80a0\u9053\u83cc\u7fa4\u6539\u53d8\u5f71\u54cd\u80a0\u9053\u5c4f\u969c\u529f\u80fd\u7684\u7a33\u5b9a \u80a0\u9053\u5fae\u751f\u7269\u662f\u7ef4\u6301\u80a0\u9053\u7a33\u6001\u7684\u91cd\u8981\u4ecb\u8d28\uff0c\u76ee\u524d\u53d1\u73b0\u67d0\u4e9b\u7279\u5b9a\u83cc\u682a\u53ef\u95f4\u63a5\u5f71\u54cd\u80a0\u9053\u7684\u5c4f\u969c\u529f\u80fd\u3002\u80a0\u9053\u5c4f\u969c\u529f\u80fd\u969c\u788d\u5df2\u88ab\u8bc1\u5b9e\u80fd\u52a0\u5feb\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3001\u75db\u98ce\u6027\u5173\u8282\u708e\u7b49\u75be\u75c5\u7684\u8fdb\u5c55\uff0c\u8fd9\u53ef\u80fd\u4e0e\u5176\u5f15\u8d77\u80a0\u9053\u901a\u900f\u6027\u589e\u52a0\u5e76\u52a0\u91cd\u9ad8\u5c3f\u9178\u8840\u75c7\u6709\u5173\u3002\u65e9\u671f\u7814\u7a76\u53d1\u73b0\uff0c\u76ca\u751f\u83cc\u901a\u8fc7\u7ade\u4e89\u8425\u517b\u7269\u8d28\u548c\u9ecf\u9644\u90e8\u4f4d\u3001\u5206\u6ccc\u6297\u83cc\u80bd\u4fdd\u62a4\u80a0\u9053\u4e0a\u76ae\u8868\u9762\uff0c\u4ee5\u9632\u5fa1\u75c5\u539f\u4f53\u5e76\u9650\u5236\u5176\u4e0e\u80a0\u9053\u9ecf\u819c\u7684\u76f4\u63a5\u63a5\u89e6\uff0c\u4ece\u800c\u6709\u6548\u9632\u6b62\u75c5\u539f\u4f53\u7684\u4fb5\u88ad\u3002\u80a0\u9053\u83cc\u7fa4\u7ed3\u6784\u6539\u53d8\u4e0d\u4ec5\u80fd\u5f15\u8d77\u77ed\u94fe\u8102\u80aa\u9178\u6d53\u5ea6\u964d\u4f4e\uff0c\u4e5f\u4f1a\u5bfc\u81f4\u7ef4\u6301\u80a0\u9053\u5c4f\u969c\u5b8c\u6574\u6027\u7684\u80fd\u529b\u51cf\u5f31\uff0c\u8fdb\u4e00\u6b65\u5f71\u54cd\u80a0\u9053\u4e0a\u76ae\u5bf9\u4f53\u5185\u7ec6\u83cc\u6bd2\u7d20\u53ca\u75c5\u539f\u4f53\u7684\u62b5\u5fa1\u80fd\u529b\uff0c\u751a\u81f3\u9020\u6210\u7ec6\u83cc\u6216\u7ec6\u83cc\u4ea7\u7269\u5982\u8102\u591a\u7cd6\u7684\u6613\u4f4d\uff0c\u800c\u8fd9\u52bf\u5fc5\u9020\u6210\u9ad8\u5c3f\u9178\u8840\u75c7\u6216\u75db\u98ce\u60a3\u8005\u8840\u6db2\u5185\u6bd2\u7d20\u6c34\u5e73\u7684\u5347\u9ad8\u3002\u591a\u9879\u7814\u7a76\u53d1\u73b0\uff0c\u8102\u591a\u7cd6\u4e0d\u4ec5\u80fd\u591f\u89e6\u53d1\u5148\u5929\u514d\u75ab\uff0c\u8fd8\u80fd\u6fc0\u6d3b\u708e\u6027\u7ec6\u80de\uff0c\u52a0\u5feb\u5168\u8eab\u6027\u6162\u6027\u708e\u75c7\u4ee5\u53ca\u4ee3\u8c22\u7d0a\u4e71\u7684\u53d1\u5c55\u3002\u4f8b\u5982\uff0c\u5916\u6e90\u6027\u8102\u591a\u7cd6\u53ef\u8bf1\u5bfc\u5168\u8eab\u708e\u75c7\u5f15\u8d77\u8102\u80aa\u6027\u809d\u708e\uff0c\u6216\u8005\u7ecf\u8fc7\u5185\u6bd2\u7d20\u8102\u591a\u7cd6-Toll\u6837\u53d7\u4f534(lipopolysaccharides-Toll-like receptor 4\uff0cLPS-TLR4)\/NF-\u03baB\u3001\u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b501(insulinlike growth factor 1\uff0cIGF-1)\/\u54fa\u4e73\u52a8\u7269\u96f7\u5e15\u9709\u7d20\u9776\u86cb\u767d(mammalian target of rapamycin\uff0cmTOR)\/\u524d\u5217\u817a\u7d20E2(prostaglandin E2\uff0cPGE2)\u4fe1\u53f7\u901a\u8def\u5f15\u53d1\u8f6f\u9aa8\u6027\u5173\u8282\u708e\u3002<\/p>\n

\u80a0\u9053\u83cc\u7fa4\u53ef\u901a\u8fc7\u5e72\u6270\u80a0\u9053\u5c4f\u969c\u529f\u80fd\u8c03\u8282\u8102\u8d28\u4ee3\u8c22\uff0c\u4ece\u800c\u5f71\u54cd\u75be\u75c5\u7684\u53d1\u5c55\u3002\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u5bcc\u542b\u560c\u5464\u7684\u98df\u7269\u4e2d\u8102\u80aa\u9178\u542b\u91cf\u8f83\u591a\uff0c\u800c\u8102\u80aa\u9178\u80fd\u591f\u63d0\u5347\u5c3f\u9178\u76d0\u6676\u4f53\u7684\u4fc3\u708e\u7279\u6027\uff0c\u88ab\u8ba4\u4e3a\u662f\u9971\u98df\u540e\u75db\u98ce\u6025\u6027\u53d1\u4f5c\u7684\u8bf1\u5bfc\u5242\u3002\u53e6\u5916\uff0cAntharam\u7b49\u7814\u7a76\u53d1\u73b0\uff0c\u80a0\u9053\u83cc\u7fa4\u53ef\u76f4\u63a5\u5f71\u54cd\u80c6\u56fa\u9187\u4ee3\u8c22\uff0c\u5982\u53cc\u6b67\u6746\u83cc\u3001\u4e73\u9178\u83cc\u548c\u80c3\u94fe\u7403\u83cc\u53c2\u4e0e\u4e86\u80c6\u56fa\u9187\u8f6c\u6362\u8fc7\u7a0b\u3002\u603b\u4e4b\uff0c\u80a0\u9053\u83cc\u7fa4\u5931\u7a33\u4f1a\u5f71\u54cd\u80a0\u9053\u5c4f\u969c\u529f\u80fd(\u5982\u80a0\u9053\u4e0a\u76ae\u5b8c\u6574\u6027)\u53ca\u514d\u75ab\u673a\u5236\uff0c\u4ece\u800c\u5f15\u53d1\u4ee3\u8c22\u7ec4\u7ec7\u708e\u75c7\uff0c\u52a0\u5267\u4ee3\u8c22\u7d0a\u4e71\uff0c\u8fd9\u4e3a\u9ad8\u5c3f\u9178\u8840\u75c7\u53ca\u75db\u98ce\u7684\u53d1\u75c5\u673a\u5236\u63d0\u4f9b\u4e86\u65b0\u7684\u7814\u7a76\u65b9\u5411\u3002\u7136\u800c\uff0c\u8fd9\u4e00\u9886\u57df\u7684\u7814\u7a76\u4ecd\u5b58\u5728\u4e0d\u8db3\uff0c\u4eca\u540e\u9700\u91cd\u70b9\u5173\u6ce8\u5fae\u751f\u7269\u4e0e\u673a\u4f53\u76f8\u4e92\u4f5c\u7528\u7684\u5177\u4f53\u9014\u5f84\uff0c\u786e\u5b9a\u8fd9\u79cd\u673a\u5236\u7684\u5206\u5b50\u57fa\u7840\uff0c\u6709\u52a9\u4e8e\u9776\u5411\u80a0\u9053\u83cc\u7fa4\u8c03\u8282\u9ad8\u5c3f\u9178\u8840\u75c7\uff0c\u964d\u4f4e\u75db\u98ce\u53d1\u4f5c\u7387\u3002<\/p>\n

\u200b\u200b<\/p>\n

\u8d3e\u6653\u5468\uff08\u5fae\u4fe1\uff1a18704099845\uff09\uff0c\u6bd5\u4e1a\u4e8e\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u4e34\u5e8a\u533b\u5b66\u7cfb\uff0c2008\u5e74\u8fbd\u5b81\u4e2d\u533b\u836f\u5927\u5b66\u9644\u5c5e\u533b\u9662\u8fdb\u4fee\uff0c\u540e\u5c31\u804c\u4e8e\u8fbd\u5b81\u822a\u7a7a\u822a\u5929\u9644\u5c5e\u533b\u9662\uff0c\u66fe\u53d7\u8058\u4e8e\u5317\u4eac\u81f3\u9053\u4e2d\u533b\u7814\u7a76\u9662\u4efb\u526f\u9662\u957f\uff0c\u91cd\u5e86\u6708\u829d\u6797\u547c\u5438\u6162\u75c5\u8fde\u9501\u673a\u6784\u4f1a\u8bca\u4e13\u5bb6\u3001\u4e16\u754c\u533b\u7597\u5065\u5eb7\u7ba1\u7406\u534f\u4f1a\u4f1a\u5458\uff0c\u591a\u5bb6\u4e34\u5e8a\u533b\u836f\u4f01\u4e1a\u5b66\u672f\u987e\u95ee\u3002\u76ee\u524d\u4e3b\u8981\u4ece\u4e8b\u547c\u5438\u9886\u57df\u76f8\u5173\u75be\u75c5\u4e34\u5e8a\u8bca\u7597\u8fdb\u5c55\u79d1\u7814\u5de5\u4f5c\uff0c\u56fd\u5185\u5916\u5148\u8fdb\u7279\u8272\u8bca\u7597\u6280\u672f\u6316\u6398\u53ca\u6574\u7406\u3002\u66fe\u53c2\u52a0\u4e2d\u56fd\u54b3\u55fd\u8bca\u7597\u6307\u5357\u4e07\u91cc\u884c\u5de1\u8bb2\uff0c\u4f5c\u4e3a\u201c\u6c14\u9053\u708e\u75c7\u4e13\u573a\u201d\u7279\u9080\u4e13\u5bb6\uff0c2018\u5e74\u53d1\u8d77\u201c\u4e2d\u56fd\u57fa\u5c42\u54b3\u55fd\u8bca\u7597\u6307\u5357\u4e07\u91cc\u884c\u201d\u6d3b\u52a8\uff0c2020\u5e74\u53d1\u8d77\u201c\u4e2d\u56fd\u57fa\u5c42\u513f\u7ae5\u54b3\u5598\u75c5\u5168\u56fd\u5de1\u8bb2\u201d\u6d3b\u52a8\uff0c2021\u5e74\u53d1\u8d77\u201c\u4e2d\u56fd\u57fa\u5c42\u6162\u75c5\u89c4\u8303\u5316\u8bca\u6cbb\u201d\u5168\u56fd\u5de1\u8bb2\u6d3b\u52a8\uff0c2023\u5e74\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u53ca\u5176\u5e76\u53d1\u75c7\u7684\u4e34\u5e8a\u89c4\u8303\u5316\u8bca\u6cbb\u65b9\u6848\u66f4\u65b0\uff0c\u63a8\u8fdb\u57fa\u5c42\u300a\u65b0\u51a0\u611f\u67d3\u54b3\u55fd\u4e13\u79d1\u95e8\u8bca\u300b\u3001\u300a\u547c\u5438\u6162\u75c5\u4e13\u79d1\u95e8\u8bca\u300b\u7b49\u4e13\u79d1\u95e8\u8bca\u673a\u6784\u7684\u5efa\u7acb\uff0c2024\u5e74\u91cd\u70b9\u63a2\u7d22\u201c\u80a0\u9053\u5fae\u751f\u6001\u4e0e\u4eba\u7c7b\u5065\u5eb7\u53ca\u75be\u75c5\u201d\u76f8\u5173\u4e34\u5e8a\u8fdb\u5c55\u3002\u7acb\u8db3\u4e8e\u76ee\u524d\u4e34\u5e8a\u6700\u65b0\u8fdb\u5c55\u547c\u5438\u9886\u57df\uff1a\u9636\u68af\u5f0f\u6cbb\u7597\u65b9\u6848\u3001\u547c\u5438\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u3001\u4e0a\u4e0b\u6c14\u9053\u540c\u6cbb\u6cbb\u7597\u65b9\u6848\u3001\u7cbe\u51c6\u5316\u8bca\u6cbb\u6cbb\u7597\u65b9\u6848\u3001\u547c\u5438\u75c5\u75c7\u72b6\u5feb\u901f\u8bc4\u4f30\u3001\u547c\u5438\u75c5\u5feb\u901f\u95ee\u8bca\u53ca\u9488\u5bf9\u4e2d\u897f\u533b\u7ed3\u5408\u4e34\u5e8a\u4e00\u7ebf\u6307\u5357\u63a8\u8350\u7528\u836f\u7b49\u505a\u5168\u9762\u603b\u7ed3\u7814\u7a76\uff0c\u4ee5\u5e2e\u52a9\u66f4\u591a\u7684\u540c\u4ec1\u5b8c\u6210\u79d1\u5b66\u3001\u7cbe\u51c6\u3001\u89c4\u8303\u7684\u8bca\u6cbb\uff0c\u5f00\u5c55\u66f4\u591a\u533b\u7597\u53ca\u5065\u5eb7\u7ba1\u7406\u5b66\u672f\u4ea4\u6d41\u4f1a\u8bae\uff0c\u63a8\u8fdb\u56fd\u9645\u75be\u75c5\u9884\u9632\u3001\u79d1\u5b66\u5065\u5eb7\u7ba1\u7406\u53ca\u80a0\u9053\u5fae\u751f\u6001\u7597\u6cd5\u65b0\u7406\u5ff5\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u80a0\u9053\u662f\u4eba\u4f53\u6700\u5927\u7684\u514d\u75ab\u5668\u5b98\uff0c\u80a0\u9053\u5185\u5b9a\u690d\u7684\u5404\u80a0 … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-60435","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/60435","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=60435"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/60435\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=60435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=60435"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=60435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}