{"id":58127,"date":"2025-09-30T05:12:15","date_gmt":"2025-09-30T05:12:15","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=58127"},"modified":"2025-09-30T05:12:15","modified_gmt":"2025-09-30T05:12:15","slug":"%e5%8d%97%e6%96%b9%e5%8c%bb%e7%a7%91%e5%a4%a7%e5%ad%a6%e5%bc%a0%e7%a6%8f%e5%bb%ba%e5%9b%a2%e9%98%9f%e6%8f%ad%e7%a4%ba%e4%ba%86%e8%82%be%e6%8d%9f%e4%bc%a4%e5%90%8e%e4%b8%a5%e9%87%8d%e6%80%a5%e6%80%a7","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=58127","title":{"rendered":"\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5f20\u798f\u5efa\u56e2\u961f\u63ed\u793a\u4e86\u80be\u635f\u4f24\u540e\u4e25\u91cd\u6025\u6027\u80be\u635f\u4f24\u540e\u80be\u8fd1\u7aef\u5c0f\u7ba1\u7684\u518d\u751f\/\u4fee\u590d\u65b0\u9776\u70b9"},"content":{"rendered":"<p>\u6765\u6e90\uff1a\u751f\u7269\u8c37\u539f\u521b 2023-04-18 17:35<\/p>\n<p>                    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&nbsp;&nbsp;&nbsp;<\/p>\n<p>\u8fd1\u65e5\uff0c\u6765\u81ea\u5357\u65b9\u533b\u79d1\u5927\u5b66\u7684\u7814\u7a76\u8005\u4eec\u5728Theranostics.\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cWT1<sup>+<\/sup> glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury\u201d\u7684\u6587\u7ae0\uff0c\u8be5\u7814\u7a76\u53d1\u73b0\u4e00\u7ec4WT1<sup>+<\/sup> 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<\/sup>PECs\u662f\u5426\u5728AKI\u540e\u7684\u80be\u810f\u518d\u751f\/\u4fee\u590d\u4e2d\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n<p>\u7814\u7a76\u8005\u91c7\u7528\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\uff08IRI\uff09\u5c0f\u9f20\u6a21\u578b\uff0c\u7814\u7a76\u4e25\u91cd\u6025\u6027\u80be\u635f\u4f24\u540e\u80be\u7ec4\u7ec7WT1\u7684\u8868\u8fbe\u6a21\u5f0f\u3002\u4f7f\u7528Pax8<sup>CreERT2<\/sup>\u548cWT1<sup>fl\/fl<\/sup>\u5c0f\u9f20\u4ea7\u751fWT1\u57fa\u56e0\u7684\u6761\u4ef6\u6027\u7f3a\u5931\u5c0f\u9f20\uff0c\u4ee5\u68c0\u67e5WT1\u7684\u529f\u80fd\u3002\u7136\u540e\uff0c\u8fdb\u884c\u9057\u4f20\u7ec6\u80de\u8c31\u7cfb\u8ffd\u8e2a\u548c\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u4ee5\u8bf4\u660eWT1<sup>+<\/sup> PECs\u53d1\u5c55\u4e3aWT1+\u8fd1\u7aef\u7ba1\u72b6\u4e0a\u76ae\u7ec6\u80de\uff08PTECs\uff09\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u4f53\u5916\u514b\u9686\u539f\u6027\u3001\u76f4\u63a5\u5206\u5316\u5206\u6790\u548c\u4f53\u5185\u79fb\u690d\u6765\u63ed\u793a\u8fd9\u4e9bWT1<sup>+ <\/sup>PEC\u7684\u5e72\u7ec6\u80de\u6837\u7279\u6027\u3002<\/p>\n<p>\u7ed3\u679c\u8868\u660e\uff0c\u4e25\u91cdAKI\u540e\uff0cWT1\u86cb\u767d\u5728PECs\u548cPTECs\u4e2d\u7684\u8868\u8fbe\u589e\u52a0\u3002PTECs\u548cPECs\u4e2dWT1\u57fa\u56e0\u7684\u6761\u4ef6\u6027\u7f3a\u5931\u52a0\u91cd\u4e86\u4e25\u91cd\u6025\u6027\u80be\u635f\u4f24\u540e\u7684\u80be\u5c0f\u7ba1\u635f\u4f24\u3002WT1<sup>+<\/sup> PEC\u901a\u8fc7\u77ac\u95f4\u5206\u6563\u7684\u7ba1\u72b6\u7ec6\u80de\u9636\u6bb5\u53d1\u80b2\u4e3aWT1<sup>+<\/sup> PTEC\uff0c\u8fd9\u4e9bWT1<sup>+ <\/sup>PE\u5177\u6709\u7279\u5b9a\u7684\u5e72\u7ec6\u80de\u6837\u7279\u6027\u3002<\/p>\n<\/p>\n<p>WT1<sup>+<\/sup> PECs\u5728\u4f53\u5916\u548c\u4f53\u5185\u663e\u793a\u51fa\u9ad8\u589e\u6b96\u548c\u76f4\u63a5\u5206\u5316\u6f5c\u529b<\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1ahttps:\/\/pubmed.ncbi.nlm.\/36923529\/&nbsp;&nbsp;&nbsp;<\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u8be5\u7814\u7a76\u8bc1\u660eWT1<sup>+ <\/sup>PECs\u4f5c\u4e3a\u4e00\u79cd\u7ba1\u5916\u7956\u7ec6\u80de\u6837\u7ec6\u80de\uff0c\u5728\u4e25\u91cdAKI\u540e\u53ef\u4ee5\u88ab\u6fc0\u6d3b\u5e76\u5206\u5316\u4e3aPTECs\u3002\u8fd9\u4e00\u65b0\u53d1\u73b0\u7684\u80be\u810f\u4fee\u590d\u673a\u5236\u53ef\u80fd\u662f\u5bf9\u5148\u524d\u5b58\u5728\u7684\u80be\u810f\u8fd1\u7aef\u5c0f\u7ba1\u518d\u751f\u6a21\u5f0f\u7684\u8865\u5145\u3002\u8fd9\u4e9b\u80be\u810f\u7956\u7ec6\u80de\u7684\u9610\u660e\u53ef\u80fd\u4e3a\u80be\u810f\u7c7b\u5668\u5b98\u57f9\u517b\u63d0\u4f9b\u6f5c\u5728\u7684\u7ec6\u80de\u6765\u6e90\uff0c\u5e76\u4e3a\u80be\u810f\u518d\u751f\u533b\u5b66\u63d0\u4f9b\u65b0\u7684\u7b56\u7565\u3002\uff08\u751f\u7269\u8c37 Bioon.com\uff09<\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<p>Xizhen Hong et al. WT1+ glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury . Theranostics. 2023 Feb 21;13(4):1311-1324. doi: 10.7150\/thno.79326.<\/p>\n<p>                    &nbsp;365\u7bc7&#8221; style=&#8221;border-color: currentColor; margin: 0px; padding: 0px; vertical-align: top; max-width: 100%;&#8221; alt=&#8221;\u5feb\u901f\u627e\u5230\u4eba\u4f53\u7684\u5404\u4e2a\u7a74\u4f4d&nbsp;365\u7bc7&#8221; src=&#8221;http:\/\/image109.360doc.com\/DownloadImg\/2018\/11\/1820\/147522396_18_20181118080048887&#8243; data360-src=&#8221;http:\/\/checki109.360doc.com\/DownloadImg\/2018\/11\/1820\/147522396_18_20181118080048887&#8243;&gt;365\u7bc7&#8221; style=&#8221;border-color: currentColor; margin: 0px; padding: 0px; vertical-align: top; max-width: 100%;&#8221; alt=&#8221;\u5feb\u901f\u627e\u5230\u4eba\u4f53\u7684\u5404\u4e2a\u7a74\u4f4d&nbsp;365\u7bc7&#8221; src=&#8221;http:\/\/image109.360doc.com\/DownloadImg\/2018\/11\/1820\/147522396_19_2018111808004928&#8243; data360-src=&#8221;http:\/\/checki109.360doc.com\/DownloadImg\/2018\/11\/1820\/147522396_19_2018111808004928&#8243;&gt;                     <\/p>\n<ul><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u6765\u6e90\uff1a\u751f\u7269\u8c37\u539f\u521b 2023-04-18 17:35 \u6025\u6027\u80be\u635f\u4f24\u662f\u4e00\u79cd\u5f02\u8d28\u6027\u4e34\u5e8a\u7efc &hellip; <a href=\"http:\/\/zydq.1006ss.com\/?p=58127\">\u7ee7\u7eed\u9605\u8bfb <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-58127","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/58127","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=58127"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/58127\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=58127"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=58127"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=58127"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}