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\u751f\u7406\u7279\u6027:<\/p>\n
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\u5598\u4fc3\u75f0\u6d8e\uff0c\u80f8\u8188\u4e0d\u5229\uff0c\u4e0d\u5f97\u5b89\u5367\uff1a\u4e94\u5473\u5b50 \u7d2b\u53c2 \u7518\u8349(\u7099) \u9ebb\u9ec4(\u53bb\u8282) \u6854\u6897\u5404\u4e94\u94b1 \u5fa1\u7c73\u58f3(\u53bb\u9876\uff0c\u871c\u7092\u9ec4\u8272)\u4e8c\u4e24\u3002\u300a\u536b\u751f\u5b9d\u9274\u300b<\/p>\n
\u9762\u4e0a\u9152\u523a\uff1a\u4e94\u53c2\u4e38\uff1a\u7528\u7d2b\u53c2\u3001\u4e39\u53c2\u3001\u4eba\u53c2\u3001\u82e6\u53c2\u3001\u6c99\u53c2\u5404\u4e00\u4e24\u3002\u4e3a\u672b\uff0c\u80e1\u6843\u4ec1\u6775\u548c\u4e38\uff0c\u68a7\u5b50\u5927\u3002\u6bcf\u670d\u4e09\u5341\u4e38\uff0c\u8336\u4e0b\u3002\uff08\u300a\u666e\u6d4e\u300b\uff09<\/p>\n
\u300a\u91d1\u532e\u300b\u4e2d\u7d2b\u53c2\u4ec5\u51fa\u73b0\u4e24\u4e2a\u65b9\u4e2d\uff0c\u4e00\u662f\u4e0a\u671f\u7684\u6cfd\u6f06\u6c64\uff0c\u4e00\u662f\u672c\u6587\u7684\u7d2b\u53c2\u6c64\uff0c\u300a\u957f\u6c99\u836f\u89e3\u300b\u4e2d\u7d2b\u53c2\u6027\u5473\u4e3a\u82e6\u5bd2\uff0c\u4ece\u4e94\u884c\u89d2\u5ea6\u770b\u6e05\u91d1\u6cfb\u70ed\u3002\u7d2b\u53c2\u80fd\u591f\u964d\u51b2\u9006\u800c\u7834\u51dd\u585e\uff0c\u6e05\u54b3\u55fd\u800c\u6b62\u75bc\u75db\u3002\u80ba\u3001\u5927\u80a0\u5c5e\u91d1\uff0c\u91d1\u6e05\u5219\u80ba\u6c14\u6536\u6444\uff0c\u6545\u957f\u4e8e\u655b\u8840\uff0c\u91d1\u6e05\u5219\u80ba\u6c14\u901a\u8c03\uff0c\u6545\u957f\u4e8e\u884c\u7600\u3002\u800c\u80ba\u4e0e\u5927\u80a0\u76f8\u8868\u91cc\uff0c\u80ba\u75db\u3001\u4e0b\u5229\u76f8\u4e92\u5f71\u54cd\uff0c\u95ee\u9898\u7684\u6240\u5728\u662f\u4e2d\u6c14\u4e0d\u8db3\uff0c\u571f\u4e0d\u8db3\u4e0d\u80fd\u751f\u91d1\uff0c\u7518\u8349\u8fd9\u5473\u836f\u53ef\u4ee5\u57f9\u571f\uff0c\u800c\u7d2b\u53c2\u53ef\u4ee5\u6e05\u5bd2\u70ed\u90aa\u6c14\uff0c\u7834\u80ba\u90e8\u79ef\u805a\uff0c\u901a\u4e5d\u7a8d\u3002\u6240\u4ee5\u7d2b\u53c2\u6c64\u4e2d\uff0c\u4e24\u5473\u836f\u8db3\u4ee5\u6cbb\u7597\u4e0b\u5229\u3001\u80ba\u75db\u3002\u53e6\u5916\u7d2b\u53c2\u8fd8\u6709\u5176\u4ed6\u591a\u4e2a\u529f\u6548\uff0c\u6b62\u5410\u8844\uff0c\u6d88\u75c8\u80bf\uff0c\u5229\u5c0f\u4fbf\uff0c\u6ed1\u5927\u80a0\uff0c\u6cbb\u91d1\u75ae\uff0c\u8c03\u8840\u75e2\uff0c\u7834\u7600\u8840\uff0c\u901a\u95ed\u7ecf\uff0c\u5f00\u80f8\u8188\u79ef\u805a\uff0c\u6563\u8179\u80c1\u575a\u6ee1\u3002<\/p>\n
\u300a\u91d1\u532e\u300b\u6709\u539f\u6587\u201c\u4e0b\u5229\u80ba\u75db\uff0c\u7d2b\u53c2\u6c64\u4e3b\u4e4b\u3002\u201d\u7d2b\u53c2\u6c64\uff0c\u7d2b\u53c2\u534a\u65a4\uff0c\u7518\u8349\u4e09\u4e24\u3002\u4ee5\u6c34\u4e94\u5347\uff0c\u5148\u716e\u7d2b\u53c2\uff0c\u53d6\u4e8c\u5347\uff0c\u5185\u7518\u8349\uff0c\u716e\u53d6\u4e00\u5347\u534a\uff0c\u5206\u6e29\u4e09\u670d\u3002\u80ba\u75db\u65f6\u8868\u660e\u75bc\u75db\u5df2\u8fbe\u80f8\u819c\uff0c\u73b0\u5728\u770b\u6765\u5f88\u6709\u53ef\u80fd\u662f\u80ba\u764c\u7684\u75c7\u72b6\uff0c\u800c\u7d2b\u53c2\u6c64\u4e2d\u7684\u7d2b\u53c2\uff08\u77f3\u89c1\u7a7f\uff09\u6070\u597d\u662f\u4e00\u5473\u80fd\u591f\u6297\u80bf\u7624\u7684\u4e2d\u836f\uff0c\u80fd\u591f\u901a\u4e5d\u7a8d\u3001\u6d88\u80f8\u8179\u79ef\u805a\u3002\u4e2d\u533b\u6240\u8c13\u79ef\u805a\uff0c\u805a\u8bc1\u4ee5\u6c14\u6ede\u4e3a\u4e3b\uff0c\u79ef\u8bc1\u4ee5\u8840\u7600\u4e3a\u4e3b\uff0c\u79ef\u8005\u4e94\u810f\u6240\u751f\uff0c\u805a\u8005\u516d\u8151\u6240\u6210\u3002\u80ba\u764c\u591a\u4e3a\u79ef\uff0c\u800c\u7d2b\u53c2\u6d3b\u8840\u5316\u7600\u529f\u6548\u5f3a\uff0c\u53c8\u540d\u6d3b\u8840\u8349\uff0c\u6cbb\u7597\u80ba\u764c\u6548\u679c\u62d4\u7fa4\u3002\u4e0d\u4ec5\u4ec5\u662f\u80ba\u764c\uff0c\u80f8\u8179\u4e5d\u7a8d\u4e4b\u95f4\uff0c\u5927\u90e8\u5206\u79ef\u805a\u90fd\u53ef\u4ee5\u7528\u7d2b\u53c2\u8fd9\u5473\u4e2d\u836f\u6765\u914d\u4f0d\u3002<\/p>\n
\u300a\u91d1\u532e\u65b9\u6b4c\u62ec\u300b\u9648\u4fee\u56ed\u4f5c\u6b4c\u66f0\uff1a\u201c\u5229\u800c\u80ba\u75db\u662f\u4f55\u4f24\uff0c\u6d4a\u6c14\u4e0a\u5e72\u8d23\u80c3\u80a0\uff0c\u516b\u4e24\u7d2b\u53c2\u4e09\u4e24\u8349\uff0c\u901a\u56e0\u901a\u7528\u7ec6\u63a8\u8be6\u3002\u201d<\/p>\n
\u73b0\u4ee3\u4e2d\u533b\u533b\u6848\uff1a<\/p>\n
\u8457\u540d\u4e2d\u533b\u502a\u6d77\u53a6\u8001\u5e08\u66fe\u6cbb\u7597\u4e00\u4f4d\u4e73\u817a\u764c\u8f6c\u79fb\u80ba\u764c\u7684\u60a3\u8005\uff0c\u60a3\u8005\u54b3\u55fd\u3001\u80ba\u75db\u3001\u53e3\u6e34\uff0c\u7eb3\u7720\u53ef\uff0c\u5927\u4fbf\u4e00\u65e5\u4e00\u5230\u4e24\u6b21\u3002\u8109\u8c61\u5de6\u8109\u7f13\u6709\u529b\uff0c\u91cd\u6309\u65e0\uff0c\u53f3\u8109\u5f26\u6570\uff0c\u5927\uff0c\u5bf8\u4e0a\u5bf8\u6a2a\u5165\u638c\u3002\u820c\u82d4\u6de1\u767d\u539a\uff0c\u4e24\u4fa7\u9f7f\u75d5\u3002\u8bca\u65ad\u4e3a\u5fc3\u80be\u9633\u4e0d\u8db3\uff0c\u80ba\u5bb6\u9634\u5b9e\u3002\u6574\u65b9\u5982\u4e0b\uff1a<\/p>\n
\u6854\u6897\u516b\u94b1 \u7099\u7518\u8349\u4e09\u94b1 \u7d2b\u53c2\u56db\u94b1 \u5c04\u5e72\u4e09\u94b1 \u9ebb\u9ec4\u4e09\u94b1 \u7d2b\u82d1\u4e09\u94b1 \u51ac\u82b1\u4e8c\u94b1 \u751f\u9644\u5b50\u4e09\u94b1(\u53e6\u5305) \u6842\u679d\u4e94\u94b1 \u5e72\u59dc\u4e8c\u94b1 \u8fdc\u5fd7\u4e94\u94b1 \u719f\u5730\u4e8c\u94b1 \u6cfd\u6cfb\u56db\u94b1 \u8865\u9aa8\u8102\u4e09\u94b1 \u5c04\u5e72\u4e09\u94b1 \u9ebb\u9ec4\u4e09\u94b1 \u7d2b\u82d1\u4e09\u94b1 \u51ac\u82b1\u4e8c\u94b1 \u7261\u86ce\u516b\u94b1 \u74e6\u695e\u5b50\u4e94\u94b1 \u4e73\u9999\u4e8c\u94b1 \u4e39\u76ae\u4e09\u94b1 \u6843\u4ec1\u4e09\u94b1 \u5f53\u5f52\u4e8c\u94b1 \u67f4\u80e1\u4e09\u94b1 \u7389\u91d1\u4e94\u94b1 \u9f99\u80c6\u8349\u4e09\u94b1 \u9ec4\u8fde\u4e8c\u94b1 \u9ec4\u82a9\u4e09\u94b1 \u767d\u828d\u4e94\u94b1<\/p>\n
\u5341\u4ed8\uff0c\u5341\u4e8c\u7897\u6c34\u716e\u56db\u7897\uff0c\u5e76\u53ee\u5631\u75c5\u4eba\u987b\u6bcf\u65e5\u8fd0\u52a8\u6c57\u51fa\u4ee5\u953b\u934a\u9633\u6c14,\u5f3a\u5fc3\u3002<\/p>\n
\u5176\u4e2d\u6854\u6897\u516b\u94b1 \u7099\u7518\u8349\u4e09\u94b1 \u7d2b\u53c2\u56db\u94b1->\u6cbb\u80ba\u764c\u4e3b\u529b\uff0c\u53ef\u4ee5\u53c2\u8003\u3002<\/p>\n
\u73b0\u4ee3\u836f\u7406\u5b66\u7814\u7a76\uff1a<\/p>\n
\u6c2f\u4eff\u90e8\u4f4d\u3001\u4e59\u9178\u4e59\u916f\u90e8\u4f4d\u662f\u77f3\u89c1\u7a7f\u53d1\u6325\u4f53\u5916\u6297\u80bf\u7624\u4f5c\u7528\u7684\u4e3b\u8981\u6d3b\u6027\u90e8\u4f4d[1], \u5176\u4e3b\u8981\u5316\u5b66\u6210\u5206\u5305\u62ec\u7cd6\u7c7b\u3001\u841c\u7c7b\u3001\u753e\u9187\u7c7b\u3001\u591a\u915a\u7c7b\u7b49\u3002\u67f3\u82b3\u7b49[2]\u901a\u8fc7\u4f53\u5185\u8bd5\u9a8c\u89c2\u5bdf\u77f3\u89c1\u7a7f\u5bf9\u809d\u764cH22\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u7684\u5f71\u54cd, \u7ed3\u679c\u53d1\u73b0:\u4e0e\u6a21\u578b\u7ec4\u6bd4\u8f83, \u77f3\u89c1\u7a7f\u63d0\u53d6\u7269\u9ad8\u3001\u4e2d\u3001\u4f4e\u5242\u91cf\u7ec4\u7684\u6291\u7624\u7387\u5206\u522b\u4e3a23.83%, 48.93% (P<0.01) \u548c27.48% (P<0.05) ;\u94b1\u6653\u840d\u7b49[3]\u91c7\u7528\u7cfb\u7edf\u6eb6\u5242\u6cd5\u3001\u68af\u5ea6\u6d17\u8131\u3001\u67f1\u8272\u8c31\u5206\u79bb\u3001\u91cd\u7ed3\u6676\u7b49\u65b9\u6cd5, \u4ece\u77f3\u89c1\u7a7f\u6c2f\u4eff\u90e8\u4f4d\u5206\u79bb\u5f97\u5230\u718a\u679c\u9178\u3002\u901a\u8fc7\u567b\u5511\u84dd\u8fd8\u539f\u6cd5 (MTT\u6cd5) \u68c0\u6d4b\u663e\u793a, \u718a\u679c\u9178\u5bf95\u682a\u4eba\u80bf\u7624\u7ec6\u80de\u682a\u5177\u6709\u8f83\u5f3a\u7684\u751f\u957f\u6291\u5236\u4f5c\u7528, \u5e76\u5448\u73b0\u5242\u91cf\u4f9d\u8d56\u5173\u7cfb\u3002\u6d53\u5ea6\u5728\u2265100\u03bcg\/ml\u5bf9\u5404\u682a\u7ec6\u80de\u682a\u7684\u751f\u957f\u6291\u5236\u4f5c\u7528\u663e\u8457\u3002\u5bf9\u4eba\u80ba\u764c\u7ec6\u80de\u682aA549\u7684\u6291\u5236\u4f5c\u7528\u6700\u660e\u663e, \u5176IC50\u503c\u662f30.79\u03bcg\/ml, \u8f83\u5bf9\u5176\u5b83\u7ec6\u80de\u682a\u6709\u663e\u8457\u6027\u5dee\u5f02 (P<0.05) \u3002\u7ec6\u80de\u5f62\u6001\u89c2\u5bdf\u63d0\u793a, \u718a\u679c\u9178\u80fd\u591f\u4f7f\u80bf\u7624\u7ec6\u80de\u5f62\u6001\u53d1\u751f\u53d8\u5316, \u4fc3\u4f7f\u7ec6\u80de\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u662f\u901a\u8fc7\u5176\u7ec6\u80de\u6bd2\u4f5c\u7528\u5b9e\u73b0\u7684\u3002\u90d1\u6d77\u97f3\u7b49[4]\u901a\u8fc7\u6b63\u4ea4\u5b9e\u9a8c\u786e\u5b9a\u63d0\u53d6\u591a\u7cd6\u7684\u4f18\u5316\u6761\u4ef6, \u7528\u84bd\u916e\u4e00\u786b\u9178\u6cd5\u6d4b\u5b9a\u591a\u7cd6\u7684\u542b\u91cf, \u5e76\u901a\u8fc7MTT\u6cd5\u8bc1\u5b9e\u77f3\u89c1\u7a7f\u591a\u7cd6\u5bf9\u4f53\u5916\u4eba\u809d\u764c\u7ec6\u80de\u589e\u6b96\u7684\u6291\u5236\u4f5c\u7528\u3002\u5e9e\u58f0\u822a\u7b49[5]\u5bf9\u77f3\u89c1\u7a7f\u7b493\u79cd\u89e3\u6bd2\u7c7b\u4e2d\u836f\u6750\u63d0\u53d6\u7269\u8fdb\u884c\u6297\u80bf\u7624\u4f53\u5185\u7b5b\u9009\u7814\u7a76, \u5206\u522b\u89c2\u5bdf\u4e0d\u540c\u5242\u91cf (\u5206\u9ad8\u3001\u4e2d\u3001\u4f4e\u5242\u91cf\u7ec4) \u63d0\u53d6\u7269\u5bf9\u5b9e\u4f53\u7624\u5c0f\u9f20\u7684\u6291\u7624\u7387 (\u7ed9\u836f\u7ec4) , \u5e76\u4e0e\u8179\u8154\u6ce8\u5c04\u73af\u78f7\u9170\u80fa\u9633\u6027\u5bf9\u7167\u7ec4\u53ca\u6bcf\u5929\u704c\u80c3\u7b49\u91cf\u84b8\u998f\u6c34\u7684\u6a21\u578b\u7ec4\u8fdb\u884c\u7ec4\u95f4\u6bd4\u8f83, \u7ed3\u679c:\u77f3\u89c1\u7a7f\u63d0\u53d6\u7269\u9ad8\u3001\u4e2d\u5242\u91cf\u5bf9\u5c0f\u9f20H22\u5b9e\u4f53\u7624\u6709\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528 (P<0.05\u6216P<0.01) , \u9ad8\u5242\u91cf\u5bf9\u5c0f\u9f20\u5b9e\u4f53\u7624\u5177\u6709\u5341\u5206\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528 (P<0.01) \u3002<\/p>\n
\u53c2\u8003\u6587\u732e\uff1a<\/p>\n
[1] \u5f90\u656c\u5ba3, \u859b\u59e3, \u6797\u9ece, \u7b49.\u77f3\u89c1\u7a7f\u6d3b\u6027\u90e8\u4f4d\u7684\u4f53\u5916\u6297\u80bf\u7624\u4f5c\u7528\u7814\u7a76[C].\u4e2d\u534e\u533b\u5b66\u4f1a\u80bf\u7624\u5b66\u5206\u4f1a\u7b2c\u4e03\u5c4a\u5168\u56fd\u4e2d\u9752\u5e74\u80bf\u7624\u5b66\u672f\u4f1a\u8bae, \u5c71\u4e1c\u6d4e\u5357, 2011:1.<\/p>\n
[2] \u67f3\u82b3, \u5218\u5efa\u52cb, \u674e\u519b\u6885, \u7b49.\u77f3\u89c1\u7a7f\u5bf9\u809d\u764cH22\u8377\u7624\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u7684\u5f71\u54cd[J].\u4e2d\u56fd\u5b9e\u9a8c\u65b9\u5242\u5b66\u6742\u5fd7, 2012, 8 (12) :249.<\/p>\n
[3]\u94b1\u6653\u840d, \u5f90\u656c\u5ba3, \u6797\u9ece, \u7b49.\u4e2d\u836f\u77f3\u89c1\u7a7f\u63d0\u53d6\u7269\u718a\u679c\u9178\u4f53\u5916\u6291\u5236\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u7684\u5b9e\u9a8c\u7814\u7a76[J].\u73b0\u4ee3\u80bf\u7624\u533b\u5b66, 2012, 20 (11) :2244-2248.<\/p>\n
[4]\u90d1\u6d77\u97f3, \u5f90\u4f1f, \u90d1\u6653\u71d5, \u7b49.\u77f3\u89c1\u7a7f\u591a\u7cd6\u7684\u63d0\u53d6\u53ca\u5176\u5bf9\u809d\u764c\u7ec6\u80de\u589e\u6b96\u7684\u6291\u5236\u4f5c\u7528[J].\u4e2d\u56fd\u4e2d\u533b\u836f\u79d1\u6280, 2008, 15 (5) :360-362.<\/p>\n
[5]\u5e9e\u58f0\u822a, \u5415\u7433, \u66fe\u7fe0\u743c.\u53f6\u4e0b\u73e0\u7b493\u79cd\u89e3\u6bd2\u7c7b\u58ee\u836f\u6750\u6297\u80bf\u7624\u4f53\u5185\u7b5b\u9009\u7814\u7a76[J].\u56db\u5ddd\u4e2d\u533b, 2007, 25 (3) :47-48.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"
\u4e0a\u699c\u7406\u7531\uff1a\u6297\u764c\u4f5c\u7528 \u2605 \u2605  … \u7ee7\u7eed\u9605\u8bfb