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\n<p>\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5728\u4eca\u5e746\u6708\u4efd\uff0c\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e1c\u65b9\u533b\u9662\u56e2\u961f\u53d1\u73b0\uff1a\u4e8c\u7532\u53cc\u80cd\u53ef\u4ee5\u901a\u8fc7\u589e\u52a0\u80a0\u9053\u83cc\u7fa4\u4e2d\u7684Akkermansia muciniphila\uff08Akk\u83cc\uff09\uff0c\u51cf\u5c11\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u767d\u4ecb\u7d20-6\uff08IL-6\uff09\uff0c\u4ece\u800c\u6539\u5584\u8ba4\u77e5\u529f\u80fd\u3002<\/p>\n<p>\u671f\u5f85\u79d1\u5b66\u5bb6\u65e9\u65e5\u641e\u6e05\u695a\u80cc\u540e\u7684\u5206\u5b50\u673a\u5236\uff0c\u8ba9\u66f4\u591a\u4eba\u80fd\u4ece\u4e2d\u83b7\u76ca\u3002<\/p>\n<p>\u53c2\u8003\u6587\u732e\uff1a<\/p>\n<p>[1].Hu J, Fang M, Pike J R, et al. Prediabetes, intervening diabetes and subsequent risk of dementia: the Atherosclerosis Risk in Communities (ARIC) study[J]. Diabetologia, 2023: 1-8.<\/p>\n<p>[2].Sun M, Chen WM, Wu SY, Zhang J. Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction. Brain. 2023;awad366. doi:10.1093\/brain\/awad366<\/p>\n<p>[3].Zimmerman SC, Ferguson EL, Choudhary V, et al. Metformin Cessation and Dementia Incidence. 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