\u80a0\u6613\u6fc0\u7efc\u5408\u5f81\uff08IBS\uff09\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u6d88\u5316\u7cfb\u7edf\u75be\u75c5\uff0c\u4f1a\u5e72\u6270\u80c3\u80a0\u9053\u7684\u6b63\u5e38\u8fd0\u4f5c\u3002\u5176\u663e\u8457\u7684\u8868\u73b0\u5f62\u5f0f\u4e3a\u53cd\u590d\u7684\u8179\u80c0\u3001\u8179\u75db\u4ee5\u53ca\u6392\u4fbf\u4e60\u60ef\u7684\u5f02\u5e38\u3002\u6309\u7167\u75be\u75c5\u7684\u5177\u4f53\u8868\u73b0\uff0cIBS\u4e3b\u8981\u53ef\u4ee5\u5206\u4e3a\u56db\u79cd\u4e9a\u578b\uff0c\u5176\u4e2d\u6700\u4e3a\u5e38\u89c1\u7684\u662f\u8179\u6cfb\u4e3a\u4e3b\u7684IBS-D\u578b\u3002\u9700\u8981\u6307\u51fa\u7684\u662f\uff0cIBS-D\u7684\u53d1\u75c5\u7387\u5448\u73b0\u9010\u5e74\u4e0a\u5347\u7684\u8d8b\u52bf\u3002\u767d\u672f\u828d\u836f\u6c64(BSD)\u6e90\u4e8e\u300a\u7d20\u95ee\u75c5\u673a\u6c14\u5b9c\u4fdd\u547d\u96c6\u300b\uff0c\u5177\u5907\u8865\u76ca\u813e\u80c3\u3001\u67d4\u809d\u655b\u9634\u4e4b\u529f\u6548\uff0c\u53ef\u6709\u6548\u7f13\u89e3\u8179\u75db\u3001\u8179\u6cfb\u3001\u8179\u80c0\u7b49\u75c7\u72b6\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u6cbb\u7597IBS-D\u3002\u7814\u7a76\u8868\u660e\uff0cBSD\u901a\u8fc7\u8c03\u8282\u80a0\u9053\u514d\u75ab\u7cfb\u7edf\u3001\u51cf\u8f7b\u708e\u75c7\u53cd\u5e94\u3001\u6539\u5584\u80a0\u9053\u8fd0\u52a8\u7b49\u529f\u80fd\uff0c\u53d1\u6325\u6cbb\u7597\u6548\u679c\u3002\u5c3d\u7ba1\u5982\u6b64\uff0cBSD\u5bf9IBS-D\u4e2a\u4f53\u4ea7\u751f\u5f71\u54cd\u7684\u4f5c\u7528\u673a\u5236\u4ecd\u9700\u8fdb\u4e00\u6b65\u63a2\u8ba8\u3002<\/p>\n
\u65e5\u524d\uff0c\u4e00\u7bc7\u53d1\u8868\u5728\u300aPhytomedicine\u300b\u6742\u5fd7\uff0c\u540d\u4e3a\u201cBaizhu shaoyao decoction restores the intestinal barrier and brain-gut axis balance to alleviate diarrhea-predominant irritable bowel syndrome via FoxO1\/FoxO3a\u201d\u7684\u8bba\u6587\uff0c\u7814\u7a76\u4e86BSD\u5bf9IBS-D\u76f8\u5173\u75c7\u72b6\u7684\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n
\u56fe1 \u8bba\u6587\u9996\u9875<\/p>\n
BSD\u6539\u5584IBS-D\u6a21\u578b\u6291\u90c1\u548c\u8179\u6cfb <\/p>\n
\u7814\u7a76\u8005\u6784\u5efaIBS-D\u5927\u9f20\u6a21\u578b\u63a2\u7a76BSD\u5728\u7f13\u89e3IBS-D\u76f8\u5173\u75c7\u72b6\u65b9\u9762\u7684\u4f5c\u7528\uff0c\u5206\u522b\u8bbe\u7f6e\u5bf9\u7167\u7ec4\uff08\u5bf9\u7167\u7ec4\u5927\u9f20\u704c\u80c3\u751f\u7406\u76d0\u6c34\uff09\u3001IBS-D\uff08IBS-D\u5927\u9f20\u704c\u80c3\u751f\u7406\u76d0\u6c34\uff09\u53ca\u9633\u6027\u5bf9\u7167\u7ec4IBS-D+\u6eb4\u5316\u9499\uff08PVB\uff09(IBS-D\u5927\u9f20\u704c\u80c315 mg\/kg PVB\uff09\u3002\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0cIBS-D\u8bf1\u5bfc\u7ec4\u5927\u9f20\u7684\u4f53\u91cd\u660e\u663e\u8f7b\u4e8e\u672a\u6cbb\u7597\u7ec4\uff08p<0.05\uff09\u3002\u7136\u800c\uff0c\u63a5\u53d7\u9ad8\u5242\u91cfBSD\u6cbb\u7597\u7684\u5927\u9f20\u4f53\u91cd\u6709\u6240\u589e\u52a0\uff08p<0.05\uff09\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u89c2\u5bdf\u5404\u7ec4\u5927\u9f20\u7684\u7caa\u4fbf\u72b6\u51b5\uff0c\u53d1\u73b0IBS-D\u8bf1\u5bfc\u7ec4\u5927\u9f20\u51fa\u73b0\u8179\u6cfb\u75c7\u72b6\uff0c\u800c\u7ecfBSD\u6cbb\u7597\u540e\u8179\u6cfb\u75c7\u72b6\u660e\u663e\u6539\u5584\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cIBS-D\u8bf1\u5bfc\u663e\u8457\u964d\u4f4e\u4e86\u5927\u9f20\u7684\u6444\u98df\u91cf\u3002\u5b9e\u9a8c\u7ed3\u679c\u8fdb\u4e00\u6b65\u63ed\u793a\uff0cIBS-D\u7ec4\u7684\u5927\u4fbf\u9891\u6b21\u548c\u6c34\u5206\u542b\u91cf\u8f83\u5bf9\u7167\u7ec4\u663e\u8457\u589e\u52a0\uff1b\u800c\u7ecf\u8fc7\u4e0d\u540c\u5242\u91cf\u7684BSD\u548cPVB\u5904\u7406\u540e\uff0c\u8fd9\u4e9b\u53c2\u6570\u5747\u5f97\u5230\u663e\u8457\u964d\u4f4e\uff0c\u4e3aIBS-D\u6a21\u578b\u63d0\u4f9b\u4e86\u6709\u529b\u652f\u6491\u3002\u7efc\u4e0a\u6240\u8ff0\uff0cBSD\u5728\u7f13\u89e3IBS-D\u76f8\u5173\u75c7\u72b6\u65b9\u9762\u5177\u6709\u663e\u8457\u4f5c\u7528\u3002<\/p>\n
\u56fe2 BSD\u53ef\u6539\u5584IBS-D\u5927\u9f20\u7684\u6291\u90c1\u884c\u4e3a\u548c\u80a0\u9053\u75c7\u72b6 <\/p>\n
BSD\u53ef\u6062\u590dIBS-D\u5927\u9f20\u80a0\u9053\u5f62\u6001\u548c\u80a0\u9053\u5c4f\u969c\u529f\u80fd<\/p>\n
\u6839\u636eH&E\u548cAB-PAS\u67d3\u8272\u7ed3\u679c\uff0c\u5bf9\u7167\u7ec4\u3001IBS-D\u7ec4\u3001BSD-\u7ec4\u548cPVB\u5904\u7406\u7ec4\u7684\u5927\u9f20\u80a0\u9053\u5728\u7ed3\u6784\u548c\u5f62\u6001\u4e0a\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff0c\u8fd9\u8868\u660e\u8fd9\u4e9b\u5927\u9f20\u7684\u80a0\u9053\u6ca1\u6709\u53d7\u5230\u635f\u4f24\u6216\u53d8\u6027\u3002\u540c\u65f6\uff0c\u5404\u7ec4\u95f4\u9690\u7a9d\u6df1\u5ea6\u4e5f\u672a\u53d1\u73b0\u663e\u8457\u5dee\u5f02\u3002\u7136\u800c\uff0cIBS-D\u7ec4\u7684\u7ed2\u6bdb\u957f\u5ea6\u660e\u663e\u77ed\u4e8e\u5bf9\u7167\u7ec4\u548c\u9ad8\u5242\u91cfBSD\u7ec4\u3002<\/p>\n
\u6b64\u5916\uff0cIBS-D\u7ec4\u7684\u7ed2\u6bdb\u9ad8\u5ea6\/\u9690\u7a9d\u6df1\u5ea6\u4e4b\u6bd4(V\/C)\u76f8\u8f83\u4e8eBSD\u6cbb\u7597\u5bf9\u7167\u7ec4\u3001\u4e2d\u5242\u91cf\u7ec4\u548c\u9ad8\u5242\u91cf\u7ec4\u663e\u8457\u964d\u4f4e\u3002TUNEL\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0cIBS-D\u7ec4\u7684\u7ec6\u80de\u51cb\u4ea1\u7387\u660e\u663e\u5347\u9ad8\uff0c\u800cBSD\u548cPVB\u7ec4\u7684\u7ec6\u80de\u51cb\u4ea1\u7387\u5219\u660e\u663e\u51cf\u8f7b\u3002<\/p>\n
\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63a2\u7a76\u80a0\u9053\u5c4f\u969c\u529f\u80fd\u7684\u53d8\u5316\uff0c\u7814\u7a76\u8005\u91c7\u7528Western blotting\u6280\u672f\u5bf9\u80a0\u5c4f\u969c\u76f8\u5173\u86cb\u767d\u8fdb\u884c\u4e86\u5b9a\u91cf\u5206\u6790\u3002\u7ed3\u679c\u663e\u793a\uff0cIBS-D\u5927\u9f20\u80a0\u9053\u4e2dclaudin-1(CLDN1)\u548coccludin\u7684\u8868\u8fbe\u6c34\u5e73\u660e\u663e\u4f4e\u4e8e\u5bf9\u7167\u7ec4\u3002\u7136\u800c\uff0cPVB\u7ec4\u548cBSD\u7ec4\u7684\u663e\u8fd9\u4e9b\u86cb\u767d\u6c34\u5e73\u5374\u5448\u73b0\u9ad8\u6c34\u5e73\u3002\u6b64\u5916\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0cIBS-D\u5927\u9f20\u80a0\u9053\u4e2dZo1\u3001Cldn1\u548cOcln\u7684mRNA\u6c34\u5e73\u663e\u8457\u964d\u4f4e\uff0c\u800cDASD\u548cPVB\u589e\u52a0\u4e86IBS-D\u5927\u9f20\u7684\u8f6c\u5f55\u6c34\u5e73\u3002<\/p>\n
\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660eBSD\u53ef\u6709\u6548\u6062\u590dIBS-D\u5927\u9f20\u80a0\u9053\u5f62\u6001\u548c\u80a0\u9053\u5c4f\u969c\u529f\u80fd\u3002<\/p>\n
\u56fe3 BSD\u53ef\u6062\u590dIBS-D\u5927\u9f20\u80a0\u9053\u5f62\u6001\u548c\u80a0\u9053\u5c4f\u969c\u529f\u80fd<\/p>\n
BSD\u901a\u8fc7\u964d\u4f4e\u56de\u80a0sIgA\u542b\u91cf\u51cf\u8f7bIBS-D<\/p>\n
\u4e3a\u4e86\u6df1\u5165\u7814\u7a76BSD\u5bf9\u5927\u9f20IBS-D\u7684\u4f5c\u7528\u673a\u5236\uff0c\u7814\u7a76\u8005\u5c06\u5bf9\u7167\u7ec4\u3001IBS-D\u7ec4\u548cBSD-M\u6cbb\u7597\u7ec4\u5927\u9f20\u7684\u80a0\u7ec4\u7ec7\u8f6c\u5f55\u672c\u8fdb\u884c\u4e86\u6d4b\u5e8f\u3002\u5bf9\u6bd4\u5bf9\u7167\u7ec4\uff0cIBS-D\u7ec4\u8868\u73b0\u51fa158\u4e2a\u57fa\u56e0\u4e0a\u8c03\u548c34\u4e2a\u57fa\u56e0\u4e0b\u8c03\uff08\u56fe4A\uff09\u3002\u800cBSD\u5904\u7406\u7ec4\u5219\u67091012\u4e2a\u57fa\u56e0\u4e0a\u8c03\u548c1784\u4e2a\u57fa\u56e0\u4e0b\u8c03\uff08\u56fe4B\uff09\u3002\u6b64\u5916\uff0c\u80a0\u9053\u5185sIgA\u542b\u91cf\u4e0eIBS-D\u7684\u53d1\u751f\u5448\u6b63\u76f8\u5173\u3002GSEA\u5206\u6790\u663e\u793a\uff0cIBS-D\u5927\u9f20\u7684sIgA\u4ea7\u751f\u76f8\u5173\u901a\u8def\u4e0a\u8c03\uff08\u56fe4C\uff09\u3002\u901a\u8fc7KEGG\u9014\u5f84\u548cGO\u5bcc\u96c6\u5206\u6790\uff0c\u53d1\u73b0BSD\u6cbb\u7597\u7ec4\u548cIBS-D\u7ec4\u4e4b\u95f4\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff08DEGs\uff09\u4e3b\u8981\u6d89\u53casIgA\u4ea7\u751f\u9014\u5f84\u7684\u514d\u75ab\u7f51\u7edc\u548c\u767d\u7ec6\u80de\u4ecb\u7d20-2\u4ea7\u751f\u7684\u6b63\u8c03\u63a7\uff08\u56fe4D\u548c4E\uff09\u3002<\/p>\n
\u63a5\u4e0b\u6765\uff0c\u91c7\u7528ELISA\u6cd5\u5bf9\u80a0\u9053sIgA\u8fdb\u884c\u4e86\u5b9a\u91cf\u5206\u6790\uff0c\u7ed3\u679c\u663e\u793aIBS-D\u7ec4sIgA\u6c34\u5e73\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff08p<0.01\uff09\uff0c\u800cBSD\u548cPVB\u663e\u8457\u964d\u4f4e\u4e86IBS-D\u7ec4\u7684sIgA\u542b\u91cf\uff08p<0.01\uff09\u3002\u6b64\u5916\uff0cIHC\u5206\u6790\u786e\u5b9a\u4e86sIgA\u5728\u80a0\u9053\u4e2d\u7684\u5206\u5e03\uff0c\u5176\u7ed3\u679c\u4e0eELISA\u7ed3\u679c\u4e00\u81f4\u3002\u7efc\u4e0a\uff0c\u521d\u6b65\u7ed3\u679c\u8868\u660e\uff0cBSD\u901a\u8fc7\u6291\u5236sIgA\u7684\u8868\u8fbe\u6765\u6cbb\u7597\u5927\u9f20IBS-D\u3002<\/p>\n
\u56fe4 BSD\u901a\u8fc7\u964d\u4f4e\u56de\u80a0\u4e2dsIgA\u542b\u91cf\u6765\u51cf\u8f7bIBS-D<\/p>\n
BSD\u8c03\u8282IBS-D\u5927\u9f20FoxO1\u548cFoxO3a\u7684\u8868\u8fbe <\/p>\n
\u5728\u5bf9\u7167\u7ec4\u3001BSD-M\u5904\u7406\u7ec4\u548cIBS-D\u7ec4\u4e4b\u95f4\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u7684KEGG\u901a\u8def\u5206\u6790\u4e2d\uff0c\u53d1\u73b0FoxO\u4fe1\u53f7\u901a\u8def\u663e\u8457\u5bcc\u96c6\uff08\u5982\u56fe5A\u6240\u793a\uff09\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u8005\u6df1\u5165\u63a2\u7a76\u4e86\u53c2\u4e0eFoxO\u4fe1\u53f7\u901a\u8def\u7684\u591a\u79cd\u56e0\u5b50\u7684\u86cb\u767d\u548cmRNA\u6c34\u5e73\u3002\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0cIBS-D\u5927\u9f20\u80a0\u9053\u5185\u7684Foxo1\u3001Foxo3\u548cGsk3b\u7684mRNA\u8868\u8fbe\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff08p<0.05\u6216p<0.01\uff09\u3002<\/p>\n
\u6b64\u5916\uff0cBSD-\u7ec4\u548cPVB-\u7ec4\u5927\u9f20\u80a0\u9053\u5185\u7684Foxo1\u548cGsk3b\u7684mRNA\u8868\u8fbe\u6c34\u5e73\u5747\u9ad8\u4e8eIBS-D\u7ec4\uff08p<0.01\uff09\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cBSD-H\u7ec4\u80a0\u9053\u5185\u7684Foxo3 mRNA\u6c34\u5e73\u9ad8\u4e8eIBS-D\u7ec4\uff08p<0.01\uff1b\u5982\u56fe5B\u6240\u793a\uff09\u3002<\/p>\n
\u514d\u75ab\u5370\u8ff9\u5b9e\u9a8c\u663e\u793aBSD\u548cPVB\u53ef\u4ee5\u4e0b\u8c03IBS-D\u5927\u9f20\u80a0\u9053\u5185\u7684FoxO1\u548cFoxO3a\u7684\u86cb\u767d\u6c34\u5e73\uff08p<0.01\uff1b\u5982\u56fe5C\u548c5D\u6240\u793a\uff09\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0cFoxO\u4fe1\u53f7\u901a\u8def\u5728IBS-D\u7684\u7f13\u89e3\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n
\u56fe5 BSD\u8c03\u8282IBS-D\u5927\u9f20\u56de\u80a0Foxo1\u548cFoxO3a\u7684\u8868\u8fbe<\/p>\n
BSD\u6291\u5236IBS-D\u5927\u9f20\u80a0\u80a5\u5927\u7ec6\u80de(MCs)\u548c\u8111\u80a0\u80bd<\/p>\n
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\u7ed3\u8bba<\/p>\n
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Wei Y, Fan Y, Huang S, Lv J, Zhang Y, Hao Z. Baizhu shaoyao decoction restores the intestinal barrier and brain-gut axis balance to alleviate diarrhea-predominant irritable bowel syndrome via FoxO1\/FoxO3a. Phytomedicine. 2024 Jan;122:155163. doi: 10.1016\/j.phymed.2023.155163.<\/p>\n
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