\u4e2d\u56fd\u5fc3\u8840\u7ba1\u6742\u5fd72024Chinese Journal of Cardiovascular Medicine<\/p>\n
\u672c\u520a\u4e3a\u5317\u5927\u300a\u4e2d\u6587\u6838\u5fc3\u671f\u520a\u8981\u76ee\u603b\u89c8\u300b2023\u5e74\u7248\u5165\u7f16\u671f\u520a\u3001\u79d1\u6280\u671f\u520a\u4e16\u754c\u5f71\u54cd\u529b\u6307\u6570\uff08WJCI\uff09\u62a5\u544a2023\u6536\u5f55\u671f\u520a\u3001\u4e2d\u56fd\u79d1\u6280\u6838\u5fc3\u671f\u520a\u3001\u6b66\u5927\uff08RCCSE\uff09\u6838\u5fc3\u671f\u520a\uff0c\u6b22\u8fce\u6765\u7a3f\uff01<\/p>\n<\/p>\n
photo by laozhao<\/p>\n
\u300a\u4e2d\u56fd\u9ad8\u8840\u538b\u9632\u6cbb\u6307\u5357(2024\u5e74\u4fee\u8ba2\u7248)\u300b<\/p>\n
\u66f4\u65b0\u8981\u70b9\u89e3\u8bfb<\/p>\n
Interpretation to the update key points of 2024 Chinese guidelines for the management of hypertension<\/p>\n
\u738b\u589e\u6b66<\/p>\n
\u4f5c\u8005\u5355\u4f4d\uff1a102308 \u5317\u4eac\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u961c\u5916\u533b\u9662 \u56fd\u5bb6\u5fc3\u8840\u7ba1\u75c5\u4e2d\u5fc3\u793e\u533a\u9632\u6cbb\u90e8<\/p>\n
\u901a\u4fe1\u4f5c\u8005\uff1a\u738b\u589e\u6b66\uff0c\u7535\u5b50\u4fe1\u7bb1\uff1awangzengwu@foxmail.com<\/p>\n
\u5f15\u7528\u672c\u6587\uff1a<\/p>\n
\u738b\u589e\u6b66. \u300a\u4e2d\u56fd\u9ad8\u8840\u538b\u9632\u6cbb\u6307\u5357(2024\u5e74\u4fee\u8ba2\u7248)\u300b\u66f4\u65b0\u8981\u70b9\u89e3\u8bfb[J]. \u4e2d\u56fd\u5fc3\u8840\u7ba1\u6742\u5fd7, 2024, 29(5): 391-395. DOI: 10.3969\/j.issn.1007-5410.2024.05.001.<\/p>\n
2024\u5e748\u670811\u65e5\uff0c\u300a\u4e2d\u56fd\u9ad8\u8840\u538b\u9632\u6cbb\u6307\u5357(2024\u5e74\u4fee\u8ba2\u7248)\u300b(\u7b80\u79f0’\u65b0\u6307\u5357’)\u6b63\u5f0f\u53d1\u5e03\uff0c\u5e76\u540c\u6b65\u53d1\u8868[1]<\/sup>\u3002\u81ea2022\u5e74\u5f00\u59cb\uff0c\u4e2d\u56fd\u9ad8\u8840\u538b\u9632\u6cbb\u6307\u5357\u4fee\u8ba2\u59d4\u5458\u4f1a\u57282018\u5e74\u7248\u6307\u5357[2]<\/sup>\u7684\u57fa\u7840\u4e0a\uff0c\u8fdb\u884c\u4e86\u591a\u6b21\u4f1a\u8bae\u8ba8\u8bba\u5bf9\u6307\u5357\u8fdb\u884c\u66f4\u65b0\u4fee\u8ba2\uff0c\u7eb3\u5165\u4e86\u56fd\u5185\u5916\u9ad8\u8840\u538b\u53ca\u76f8\u5173\u75be\u75c5\u9886\u57df\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\uff0c\u5145\u5206\u4f53\u73b0\u4e86\u8fd1\u5e74\u9ad8\u8840\u538b\u9886\u57df\u7684\u9632\u6cbb\u7406\u5ff5\u3001\u73b0\u884c\u653f\u7b56\u4e0e\u9632\u6cbb\u65b9\u6cd5\u7684\u8fdb\u5c55\uff0c\u5177\u6709\u9c9c\u660e\u7684\u4e2d\u56fd\u7279\u8272\u3002\u65b0\u6307\u5357\u5bf9\u90e8\u5206\u65e2\u5f80\u5185\u5bb9\u8fdb\u884c\u4e86\u5927\u7bc7\u5e45\u66f4\u65b0\uff0c\u5305\u62ec\u6211\u56fd\u4eba\u7fa4\u9ad8\u8840\u538b\u91cd\u8981\u5371\u9669\u56e0\u7d20\u3001\u8840\u538b\u6d4b\u91cf\u548c\u9ad8\u8840\u538b\u6cbb\u7597\u7b49(\u88681)\u3002\u672c\u6587\u5c31\u6b64\u90e8\u5206\u66f4\u65b0\u7684\u5185\u5bb9\u8fdb\u884c\u89e3\u8bfb\u3002<\/p>\n \u88681 \u65b0\u6307\u5357\u66f4\u65b0\u7684\u63a8\u8350\u5185\u5bb9\u6ce8\uff1aSBP\uff1a\u6536\u7f29\u538b\uff1bDBP\uff1a\u8212\u5f20\u538b\uff1bAOBP\uff1a\u81ea\u52a8\u8bca\u5ba4\u8840\u538b\u6d4b\u91cf\uff1bBMI\uff1a\u4f53\u8d28\u6307\u6570\uff1bSPC\uff1a\u5355\u7247\u590d\u65b9\u5236\u5242PART 01\u6211\u56fd\u4eba\u7fa4\u9ad8\u8840\u538b\u91cd\u8981\u5371\u9669\u56e0\u7d20<\/p>\n \u9ad8\u8840\u538b\u4f5c\u4e3a\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u6700\u4e3b\u8981\u7684\u81f4\u75c5\u56e0\u7d20\uff0c\u5168\u7403\u5b66\u8005\u4ecd\u5728\u4e0d\u65ad\u63a2\u7d22\u9884\u9632\u9ad8\u8840\u538b\u7684\u65b9\u5f0f\u65b9\u6cd5\uff0c\u5305\u62ec\u5b83\u7684\u5f71\u54cd\u56e0\u7d20\u3002\u65b0\u6307\u5357\u5728\u5ef6\u7eed\u65e2\u5f80\u6307\u5357\u63a8\u8350\u7684\u57fa\u7840\u4e0a\uff0c\u6839\u636e\u6700\u65b0\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u7eb3\u5165\u4e86\u589e\u9f84\u3001\u5438\u70df\u3001\u7a7a\u6c14\u6c61\u67d3\u3001\u9ad8\u6d77\u62d4\u548c\u80bf\u7624\u6cbb\u7597\u7b49\u591a\u9879\u5371\u9669\u56e0\u7d20\u3002<\/p>\n \u65e2\u5f80\u5df2\u6709\u591a\u9879\u7814\u7a76\u8bc1\u5b9e\uff0c\u5e74\u9f84\u662f\u9ad8\u8840\u538b\u7684\u91cd\u8981\u5371\u9669\u56e0\u7d20\u3002\u73b0\u6709\u7814\u7a76\u8868\u660e\uff0c\u6211\u56fd\u8001\u5e74\u4eba\u7fa4\u4e2d\u9ad8\u8840\u538b\u7684\u60a3\u75c5\u7387\u8d85\u8fc750%\u3002\u7279\u522b\u662f\u968f\u7740\u8001\u9f84\u5316\u793e\u4f1a\u7684\u5230\u6765\uff0c\u6211\u56fd\u73b0\u6709\u8001\u5e74\u4eba\u53e3\u5df2\u63a5\u8fd11.76\u4ebf\uff0c\u9884\u6d4b\u52302050\u5e74\u8001\u5e74\u4eba\u53e3\u5c06\u5360\u603b\u4eba\u53e3\u76841\/3[3]<\/sup>\u3002\u8fd9\u90e8\u5206\u4eba\u7fa4\u7684\u8840\u538b\u63a7\u5236\uff0c\u5bf9\u4e8e\u6539\u5584\u751f\u6d3b\u8d28\u91cf\u3001\u9884\u9632\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u4e8b\u4ef6\u6765\u8bf4\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002\u8001\u5e74\u4eba\u7fa4\u80bf\u7624\u7684\u53d1\u75c5\u7387\u4e5f\u8f83\u9ad8\uff0c\u540c\u6837\u5bf9\u5065\u5eb7\u6784\u6210\u5a01\u80c1\u3002\u800c\u80bf\u7624\u60a3\u8005\u7684\u9ad8\u8840\u538b\u60a3\u75c5\u7387\u76f8\u5bf9\u8f83\u9ad8\uff0c\u7279\u522b\u662f\u968f\u7740\u76ee\u524d\u9776\u5411\u836f\u7269\u7684\u4f7f\u7528\u589e\u591a\uff0c\u66f4\u4f7f\u5f97\u9ad8\u8840\u538b\u7684\u60a3\u75c5\u4eba\u7fa4\u660e\u663e\u589e\u52a0\uff0c\u63a5\u53d7\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7684\u60a3\u8005\u7ea650%\u4ee5\u4e0a\u6709\u9ad8\u8840\u538b[4]<\/sup>\u3002\u6b64\u7c7b\u7279\u6b8a\u4eba\u7fa4\u7684\u9ad8\u8840\u538b\u9884\u9632\u548c\u7ba1\u7406\u4e5f\u662f\u8feb\u5728\u7709\u776b\u3002\u5438\u70df[5]<\/sup>\u3001\u7a7a\u6c14\u6c61\u67d3[6]<\/sup>\u548c\u9ad8\u6d77\u62d4[7]<\/sup>\u7b49\u73af\u5883\u56e0\u7d20\u5bf9\u4e8e\u8840\u538b\u7684\u5f71\u54cd\uff0c\u8fd1\u5e74\u6765\u4e5f\u9010\u6e10\u53d7\u5230\u4e86\u91cd\u89c6\uff0c\u4e5f\u5df2\u6709\u8bf8\u591a\u7684\u5faa\u8bc1\u8bc1\u636e\uff0c\u56e0\u800c\u4e5f\u88ab\u65b0\u6307\u5357\u63a8\u8350\u4e3a\u9ad8\u8840\u538b\u7684\u5371\u9669\u56e0\u7d20\u3002<\/p>\n \u5c3d\u7ba12018\u5e74\u7248\u6307\u5357\u4e2d\u4e5f\u5305\u62ec\u4e86\u9ad8\u76d0\u4f4e\u94be\u81b3\u98df\u3001\u8d85\u91cd\u548c\u80a5\u80d6\u3001\u793e\u4f1a\u5fc3\u7406\u56e0\u7d20\u7c7b\u4f3c\u5185\u5bb9\uff0c\u672c\u6b21\u65b0\u6307\u5357\u8fd8\u662f\u57fa\u4e8e\u65b0\u7684\u7814\u7a76\u7ed3\u679c\u505a\u4e86\u66f4\u65b0\uff0c\u4ee5\u4fdd\u8bc1\u65b0\u9896\u6027\u548c\u53ca\u65f6\u6027\u3002<\/p>\n PART 02\u8840\u538b\u6d4b\u91cf<\/p>\n \u8840\u538b\u6d4b\u91cf\u662f\u8bc4\u4f30\u3001\u8bca\u65ad\u548c\u7597\u6548\u8bc4\u4ef7\u7684\u6839\u672c\u65b9\u6cd5\u3002\u51c6\u786e\u83b7\u5f97\u60a3\u8005\u7684\u8840\u538b\u6c34\u5e73\u3001\u6ce2\u52a8\u7279\u70b9\u4ee5\u53ca\u53d8\u5316\u7279\u5f81\u662f\u975e\u5e38\u6709\u4ef7\u503c\u7684\u3002\u65b0\u6307\u5357\u5c06\u5176\u72ec\u7acb\u6210\u7ae0\u4ee5\u5f70\u663e\u5176\u91cd\u8981\u6027\u3002\u8fd1\u5e74\u6765\u968f\u7740\u6280\u672f\u7684\u8fdb\u4e00\u6b65\u5b8c\u5584\uff0c\u7535\u5b50\u8840\u538b\u8ba1\u5df2\u7ecf\u88ab\u5404\u56fd\u6240\u63a5\u53d7\u3002\u6d4b\u91cf\u65f6\u5e94\u76f8\u969430\uff5e60 s\u91cd\u590d\u6d4b\u91cf\uff0c\u53d62\u6b21\u8bfb\u6570\u7684\u5e73\u5747\u503c\u8bb0\u5f55\u3002\u5982\u679c\u6536\u7f29\u538b\u6216\u8212\u5f20\u538b\u76842\u6b21\u8bfb\u6570\u76f8\u5dee10 mmHg\u4ee5\u4e0a\uff0c\u5e94\u6d4b\u91cf3\u6b21\u53d6\u5e73\u5747\u503c\u8bb0\u5f55\u3002\u4e0d\u8fc7\u8bca\u5ba4\u8840\u538b\u6d4b\u91cf\u96be\u4ee5\u89c4\u8303\u5316\uff0c\u800c\u4e14\u5b58\u5728\u767d\u5927\u8863\u6548\u5e94\u3002\u56e0\u6b64\u5021\u8bae\u5efa\u8bbe\u81ea\u52a8\u8bca\u5ba4\u8840\u538b\u6d4b\u91cf(automated office blood pressure measurement\uff0cAOBP)\u7cfb\u7edf\uff0c\u53ef\u89e3\u51b3\u8bca\u5ba4\u8840\u538b\u6d4b\u91cf\u89c4\u8303\u5316\u7684\u95ee\u9898\u3002\u5728\u65b0\u6307\u5357\u4e2d\u660e\u786e\u5f3a\u8c03\u7535\u5b50\u8840\u538b\u8ba1\u662f\u4e3b\u8981\u7684\u6d4b\u91cf\u5de5\u5177\u3002\u4e3a\u4e86\u83b7\u5f97\u60a3\u8005\u66f4\u591a\u7684\u8840\u538b\u4fe1\u606f\uff0c\u4ee5\u53ca\u9f13\u52b1\u60a3\u8005\u7528\u591a\u79cd\u65b9\u5f0f\u53bb\u6d4b\u91cf\u8840\u538b\uff0c\u65b0\u6307\u5357\u4e5f\u5bf9\u53ef\u7a7f\u6234\u8840\u538b\u6d4b\u91cf\u7684\u65b9\u6cd5\u3001\u8840\u538b\u4ead\u6d4b\u91cf\u7684\u65b9\u6cd5\u8fdb\u884c\u4e86\u4ecb\u7ecd\u3002\u7279\u522b\u6307\u51fa\uff0c\u8bca\u5ba4\u8840\u538b\u4ecd\u7136\u662f\u73b0\u5728\u8bca\u65ad\u7684\u4e3b\u8981\u4f9d\u636e\uff1b\u5f3a\u8c03\u8bca\u5ba4\u5916\u8840\u538b\uff0c\u5305\u62ec\u52a8\u6001\u8840\u538b\u548c\u5bb6\u5ead\u8840\u538b\uff0c\u5728\u9884\u6d4b\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u4e8b\u4ef6\u65b9\u9762\u6709\u5f88\u5f3a\u7684\u6548\u5e94\u3002\u76f8\u5bf9\u4e8e\u5bf9\u7167\u7ec4\uff0c\u5bb6\u5ead\u8840\u538b\u76d1\u6d4b(home blood pressure monitoring\uff0cHBPM)\u53ef\u4ee5\u663e\u8457\u63d0\u5347\u9ad8\u8840\u538b\u7684\u63a7\u5236\u7387(66.7%\u6bd455.1%\uff0cP\uff1d0.04)[8]<\/sup>\u3002\u5728\u65b0\u6307\u5357\u4e2d\u5efa\u8bae\u8fdb\u884c5\uff5e7 d\u7684HBPM\uff0c\u65e9\u665a\u5404\u6d4b\u91cf2\uff5e3\u4e2a\u8bfb\u6570\uff1b\u5728\u4e0d\u5c11\u4e8e3 d\u300112\u4e2a\u6d4b\u91cf\u503c\u65f6\u53d6\u5e73\u5747\u503c\u7528\u4e8e\u9ad8\u8840\u538b\u7684\u8bca\u65ad\u6216\u7597\u6548\u8bc4\u4f30\u3002\u8fd8\u8865\u5145\u4e86\u56db\u80a2\u8840\u538b\u6d4b\u91cf\u548c\u4e2d\u5fc3\u52a8\u8109\u8840\u538b\u6d4b\u91cf\u5efa\u8bae\uff0c\u6709\u5229\u4e8e\u4e86\u89e3\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3001\u52a8\u8109\u72ed\u7a84\uff0c\u4ee5\u53ca\u8bc4\u4f30\u9776\u5668\u5b98\u53d7\u7d2f\u3002<\/p>\n PART 03<\/p>\n \u9ad8\u8840\u538b\u6cbb\u7597<\/p>\n 1 \u751f\u6d3b\u65b9\u5f0f\u5e72\u9884<\/p>\n \u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u4ecd\u7136\u662f\u9ad8\u8840\u538b\u9632\u6cbb\u7684\u57fa\u77f3\uff0c\u65b0\u6307\u5357\u63a8\u8350\u6240\u6709\u9ad8\u8840\u538b\u60a3\u8005\u5e94\u8fdb\u884c\u6cbb\u7597\u6027\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u3002\u8840\u538b\u6b63\u5e38\u9ad8\u503c\u7684\u4eba\u7fa4\uff0c\u5c24\u5176\u5e94\u8be5\u91cd\u89c6\u6539\u5584\u751f\u6d3b\u65b9\u5f0f\u3002\u5c3d\u7ba1\u5728\u76d0\u7684\u6444\u5165\u3001\u5408\u7406\u81b3\u98df\u65b9\u9762\u4ee5\u5f80\u4e5f\u6709\u63a8\u8350\uff0c\u4f46\u672c\u6b21\u66f4\u65b0\u8fc7\u7a0b\u4e2d\u589e\u52a0\u4e86\u6211\u56fd\u5b66\u8005\u65b0\u8fdb\u7684\u7814\u7a76\u8bc1\u636e[9-11]<\/sup>\uff0c\u4f7f\u5f97\u63a8\u8350\u66f4\u7b26\u5408\u6211\u56fd\u5c45\u6c11\u7684\u5b9e\u9645\u60c5\u51b5\u3002\u66ff\u4ee3\u76d0\u4e0e\u8111\u5352\u4e2d\u7814\u7a76(salt substitute and stroke study\uff0cSSaSS)\u4ee5\u6211\u56fd\u8111\u5352\u4e2d\u60a3\u8005\u3001\u8111\u5352\u4e2d\u9ad8\u5371\u60a3\u8005\u4e3a\u7814\u7a76\u5bf9\u8c61\uff0c\u91c7\u7528\u7684\u4f4e\u94a0\u76d0\u542b\u6709\u5927\u7ea675%\u7684\u6c2f\u5316\u94a0\u548c25%\u7684\u6c2f\u5316\u94be\u3002\u5728\u5e73\u5747\u8fd15\u5e74\u7684\u968f\u8bbf\u4e2d\uff0c\u4e0e\u98df\u7528\u666e\u901a\u76d0\u7684\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u98df\u7528\u4f4e\u94a0\u76d0\u7684\u5e72\u9884\u7ec4\u7814\u7a76\u5bf9\u8c61\u7684\u8111\u5352\u4e2d\u98ce\u9669\u964d\u4f4e\u4e8614%\uff0c\u603b\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98ce\u9669(\u5408\u5e76\u4e86\u8111\u5352\u4e2d\u548c\u5fc3\u810f\u75c5\u53d1\u4f5c)\u964d\u4f4e\u4e8613%\uff0c\u8fc7\u65e9\u6b7b\u4ea1\u7684\u98ce\u9669\u964d\u4f4e\u4e8612%[9]<\/sup>\u3002\u996e\u98df\u3001\u953b\u70bc\u548c\u5fc3\u8840\u7ba1\u5065\u5eb7\u51cf\u76d0\u7b56\u7565(diet, exercise and cardiovascular health-salt\uff0cDECIDE-salt)\u5165\u9009\u4e8648\u5bb6\u517b\u8001\u9662\u76842 248\u540d\u8001\u5e74\u4eba\uff0c\u968f\u673a\u5206\u4e3a4\u7ec4\uff1a\u9010\u6b65\u51cf\u5c11\u53a8\u623f\u4f9b\u76d0\u548c\u4f4e\u94a0\u76d0\u7ec4\u3001\u9010\u6b65\u51cf\u5c11\u53a8\u623f\u4f9b\u76d0\u7ec4\u3001\u4f4e\u94a0\u76d0\u7ec4\u548c\u5e38\u89c4\u4f9b\u76d0\u7ec4\uff0c\u5e72\u9884\u65f6\u95f4\u6301\u7eed2\u5e74\u3002\u7ed3\u679c\u663e\u793a\uff0c24\u4e2a\u6708\u65f6\u4f4e\u94a0\u76d0\u7ec4\u76f8\u6bd4\u5e38\u89c4\u4f9b\u76d0\u7ec4\u6536\u7f29\u538b\u663e\u8457\u4e0b\u964d7.1 mmHg\uff0c\u5e76\u4e14\u663e\u8457\u964d\u4f4e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98ce\u9669(HR\uff1d0.6\uff0c95%CI\uff1a0.38\uff5e0.96\uff0cP\uff1d0.03)[10]<\/sup>\u3002\u5c71\u4e1c\u76d0\u4e0e\u9ad8\u8840\u538b\u884c\u52a8\u4eba\u7fa4\u51cf\u76d0\u8ba1\u5212\uff0c\u91c7\u7528\u5236\u5b9a\u5730\u65b9\u6027\u98df\u54c1\u6807\u51c6\u548c\u6cd5\u89c4\u3001\u63a8\u5e7f\u4f4e\u94a0\u4ea7\u54c1\u3001\u5206\u53d1\u5e26\u523b\u5ea6\u7684\u76d0\u52fa\u3001\u8fdb\u884c\u5a92\u4f53\u5ba3\u4f20\u548c\u516c\u5171\u6559\u80b2\u7b49\u591a\u79cd\u7b56\u7565\uff0c5\u5e74\u540e\u4eba\u7fa424 h\u5c3f\u94a0\u6392\u6cc4\u91cf\u51cf\u5c1125%\uff0c\u94be\u6392\u6cc4\u91cf\u589e\u52a015%\uff0c\u7ecf\u8c03\u6574\u540e\u7684\u5e73\u5747\u6536\u7f29\u538b\u4ece131.8 mmHg\u964d\u81f3130.0 mmHg\uff0c\u5e73\u5747\u8212\u5f20\u538b\u4ece83.9 mmHg\u964d\u81f380.8 mmHg[11]<\/sup>\u3002\u4e2d\u56fd\u5fc3\u810f\u5065\u5eb7\u996e\u98df(Chinese heart-healthy diet\uff0cCHH)\u7814\u7a76\u53c2\u4e0e\u8005\u88ab\u968f\u673a\u5206\u62102\u7ec4\uff0c\u5bf9\u7167\u7ec4\u91c7\u7528\u5e38\u89c4\u996e\u98df\uff0c\u8bd5\u9a8c\u7ec4\u91c7\u7528CHH\u996e\u98df\uff0c\u8bd5\u9a8c\u671f\u5171\u670928 d\u3002\u4e0e\u4e2d\u56fd\u57ce\u5e02\u5e38\u89c1\u996e\u98df\u7684\u8425\u517b\u6210\u5206\u76f8\u6bd4\uff0cCHH\u996e\u98df\u4e2d\u7684\u8102\u80aa\u80fd\u91cf\u5360\u6bd4\u51cf\u5c115%\uff5e8%\uff0c\u86cb\u767d\u8d28\u80fd\u91cf\u5360\u6bd4\u589e\u52a03.5%\uff5e5.5%\uff0c\u78b3\u6c34\u5316\u5408\u7269\u80fd\u91cf\u5360\u6bd4\u589e\u52a00%\uff5e5%\u3002\u81b3\u98df\u7ea4\u7ef4\u6444\u5165\u91cf\u589e\u52a02\u500d(\u4ece11 g\/d\u523030 g\/d)\uff1b\u94be\u6444\u5165\u91cf\u4ece<1 700 mg\/d\u589e\u52a0\u52303 700 mg\/d\uff1b\u94a0\u6444\u5165\u91cf\u4ece\u8fd16 000 mg\/d\u51cf\u5c11\u52303 000 mg\/d\u3002\u4ece\u57fa\u7ebf\u5230\u5e72\u9884\u7ed3\u675f\uff0cCHH\u996e\u98df\u7ec4\u548c\u5bf9\u7167\u7ec4\u7684\u53c2\u4e0e\u8005\u6536\u7f29\u538b\u5206\u522b\u964d\u4f4e15.0 mmHg\u548c5.0 mmHg\uff0c\u8212\u5f20\u538b\u5206\u522b\u964d\u4f4e6.7 mmHg\u548c2.8 mmHg\uff1b\u4e24\u7ec4\u7684\u6536\u7f29\u538b\u53d8\u5316\u51c0\u5dee\u5f02\u4e3a\uff0d10.0 mmHg(95%CI\uff1a\uff0d12.1\uff5e\uff0d7.9)\uff0c\u8212\u5f20\u538b\u4e3a\uff0d3.8 mmHg(95%CI\uff1a\uff0d5.0\uff5e\uff0d2.5)[12]<\/sup>\u3002\u591a\u9879\u7814\u7a76\u786e\u7acb\u4e86\u80a5\u80d6\u5bf9\u4e8e\u9ad8\u8840\u538b\u7684\u5f71\u54cd\u3002\u4f53\u8d28\u6307\u6570\u6bcf\u589e\u52a01\u4e2a\u6807\u51c6\u5dee\u53ef\u4f7f\u9ad8\u8840\u538b\u53d1\u751f\u98ce\u9669\u589e\u52a053.9%[13]<\/sup>\u3002\u76f8\u6bd4\u4e8e\u4f53\u8d28\u6307\u6570\u548c\u8840\u538b\u5747\u6b63\u5e38\u7684\u4e2d\u5e74\u4eba\uff0c\u8d85\u91cd\u548c\u80a5\u80d6\u4e2d\u5e74\u4eba\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u53d1\u751f\u98ce\u9669\u5206\u522b\u589e\u52a01.4\u500d\u548c2.3\u500d[14]<\/sup>\u3002\u7eb3\u516515\u9879\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7684\u835f\u8403\u5206\u6790\u63d0\u793a\uff0c\u51cf\u8f7b\u4f53\u91cd\u53ef\u4f7f\u5168\u56e0\u6b7b\u4ea1\u964d\u4f4e15%[15]<\/sup>\u3002\u8fd9\u4e9b\u56fd\u5185\u5916\u7684\u7814\u7a76\uff0c\u4e3a\u5bf9\u9ad8\u8840\u538b\u60a3\u8005\u63a7\u5236\u94a0\u76d0\u6444\u5165\u3001\u5408\u7406\u81b3\u98df\u548c\u63a7\u5236\u4f53\u91cd\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u3002<\/p>\n 2 \u9ad8\u8840\u538b\u7684\u836f\u7269\u6cbb\u7597<\/p>\n \u867d\u7136\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u5177\u6709\u964d\u538b\u4f5c\u7528\uff0c\u4f46\u662f\u76f8\u5f53\u4e00\u90e8\u5206\u7684\u9ad8\u8840\u538b\u60a3\u8005\u8fd8\u662f\u9700\u8981\u836f\u7269\u6cbb\u7597\u3002\u65b0\u6307\u5357\u5f15\u5165\u4e86SPRINT\u7814\u7a76\u3001STEP\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u5f3a\u8c03\u4e86\u5f3a\u5316\u964d\u538b\u7684\u610f\u4e49\uff0c\u4e5f\u63a8\u8350\u5728\u80fd\u591f\u8010\u53d7\u7684\u524d\u63d0\u4e0b\u53ef\u4ee5\u5c06\u8840\u538b\u964d\u81f3130\/80 mmHg\u3002\u5c31\u670d\u836f\u65f6\u95f4\u800c\u8a00\uff0c\u65e9\u4e0a\u4e0e\u665a\u4e0a\u670d\u836f\u964d\u538b\u6cbb\u7597(treatment in morning versus evening\uff0cTIME)\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u65e9\u4e0a\u670d\u836f\u76f8\u6bd4\uff0c\u665a\u4e0a\u670d\u7528\u964d\u538b\u836f\u5e76\u4e0d\u80fd\u5e26\u6765\u66f4\u591a\u5fc3\u8840\u7ba1\u83b7\u76ca[16]<\/sup>\u3002\u56e0\u800c\uff0c\u5efa\u8bae\u9ad8\u8840\u538b\u60a3\u8005\u901a\u5e38\u5e94\u5728\u65e9\u6668\u670d\u7528\u964d\u538b\u836f\u3002\u5728\u5177\u4f53\u836f\u7269\u65b9\u9762\uff0c\u5728\u539f\u6709\u5e38\u89c4\u7684\u51e0\u7c7b\u836f\u7269\u57fa\u7840\u4e0a\uff0c\u5c06\u6c99\u5e93\u5df4\u66f2\u7f2c\u6c99\u5766[17]<\/sup>\u4f5c\u4e3a\u65b0\u4e00\u7c7b\u7684\u964d\u538b\u836f\u7269\u8fdb\u884c\u4e86\u63a8\u8350\u3002\u5728\u4e9a\u6d32\u548c\u5168\u7403\u7684\u591a\u9879\u7814\u7a76\u4e2d\uff0c\u4e0e\u8840\u7ba1\u7d27\u5f20\u7d20\u53d7\u4f53\u62ee\u6297\u5242(ARB)\u76f8\u6bd4\uff0c\u6c99\u5e93\u5df4\u66f2\u7f2c\u6c99\u5766\u53ef\u989d\u5916\u4f7f\u8bca\u5ba4\u6536\u7f29\u538b\u964d\u4f4e5\uff5e7 mmHg[18]<\/sup>\uff1b\u4f7f24 h\u52a8\u6001\u6536\u7f29\u538b\u548c\u8212\u5f20\u538b\u5206\u522b\u8fdb\u4e00\u6b65\u964d\u4f4e3.7 mmHg\u548c1.7 mmHg[19]<\/sup>\u3002\u65b0\u6307\u5357\u57fa\u4e8e\u73b0\u6709\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5bf9\u76d0\u76ae\u8d28\u6fc0\u7d20\u53d7\u4f53\u62ee\u6297\u5242\u3001\u5185\u76ae\u7d20\u53cc\u53d7\u4f53\u62ee\u6297\u5242\u7c7b\u7684\u836f\u7269\u4e5f\u8fdb\u884c\u4e86\u4ecb\u7ecd\u3002\u8fd8\u7279\u522b\u5c31\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd\u53d7\u4f53\u6fc0\u52a8\u5242(GLP-RA)\u548c\u94a0-\u8461\u8404\u7cd6\u534f\u540c\u8f6c\u8fd0\u86cb\u767d2\u6291\u5236\u5242(SGLT2i)\u7b49\u5177\u6709\u964d\u538b\u6548\u5e94\u7684\u836f\u7269\u7279\u70b9\u8fdb\u884c\u4e86\u8bf4\u660e\u3002\u6b64\u5916\uff0c\u57fa\u4e8e\u8fd1\u5e74\u6765\u4e2d\u836f\u5728\u5faa\u8bc1\u65b9\u9762\u7684\u7814\u7a76\u7ed3\u679c[20-21]<\/sup>\uff0c\u4e5f\u5f3a\u8c03\u4e86\u4e2d\u533b\u836f\u5728\u9ad8\u8840\u538b\u6cbb\u7597\u65b9\u9762\u7684\u6709\u6548\u4f5c\u7528\u3002\u5728\u9690\u853d\u6027\u9ad8\u8840\u538b\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u968f\u673a\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u5929\u9ebb\u94a9\u85e4\u9897\u7c92\u6cbb\u75974\u5468\u540e\uff0c\u4ee5\u52a8\u6001\u8840\u538b\u8bc4\u4f30\u7684\u767d\u5929\u6536\u7f29\u538b\/\u8212\u5f20\u538b\u964d\u4f4e\u4e865.44\/3.39 mmHg\uff0c\u6bd4\u5b89\u6170\u5242\u591a\u964d\u4f4e2.5\/1.8 mmHg[20]<\/sup>\u3002\u53e6\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u9633\u6027\u836f\u7269\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u677e\u9f84\u8840\u8109\u5eb7\u80f6\u56ca\u5e72\u98848\u5468\u540e\u8bca\u5ba4\u6536\u7f29\u538b\/\u8212\u5f20\u538b\u53ef\u964d\u4f4e10.5\/7.9 mmHg\uff0c\u4e0d\u52a3\u4e8e\u5bf9\u7167\u7ec4\u6c2f\u6c99\u576650 mg[21]<\/sup>\u3002\u8fd9\u4e9b\u66f4\u65b0\uff0c\u6709\u5229\u4e8e\u5168\u9762\u4e86\u89e3\u76ee\u524d\u9ad8\u8840\u538b\u6cbb\u7597\u7684\u76f8\u5173\u836f\u7269\uff0c\u4ece\u800c\u4f18\u5316\u4e34\u5e8a\u5b9e\u8df5\u3002<\/p>\n 3 \u9ad8\u8840\u538b\u7684\u5668\u68b0\u6cbb\u7597<\/p>\n \u57282018\u5e74\u7248\u6307\u5357\u4e2d\uff0c\u9274\u4e8e\u6709\u5173\u5728\u53bb\u80be\u795e\u7ecf\u672f\u6cbb\u7597\u96be\u6cbb\u6027\u9ad8\u8840\u538b\u65b9\u9762\u7684\u8bc1\u636e\u4e0d\u8db3\uff0c\u56e0\u800c\u63a8\u8350\u8fd8\u662f\u975e\u5e38\u614e\u91cd\u7684\u3002\u5728\u6700\u8fd1\u5341\u4f59\u5e74\u7684\u63a2\u7d22\u4e2d\uff0c\u5668\u68b0\u6cbb\u7597\u5728\u9650\u5b9a\u9ad8\u8840\u538b\u60a3\u8005\u4e2d\u79ef\u7d2f\u4e86\u91cd\u8981\u8bc1\u636e\u3002\u73b0\u6709\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\u4e86RDN\u6cbb\u7597\u9ad8\u8840\u538b\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027[22-23]<\/sup>\u3002SYMPLICITY HTN-3\u662f\u4e00\u9879\u5728\u7f8e\u56fd88\u4e2a\u4e2d\u5fc3\u8fdb\u884c\u7684\u5355\u76f2\u3001\u591a\u4e2d\u5fc3\u3001\u5047\u5bf9\u7167\u3001\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c[22]<\/sup>\uff0c\u5bf9\u8c61\u4e3a18\uff5e80\u5c81\u7684\u96be\u6cbb\u6027\u9ad8\u8840\u538b\u60a3\u8005\uff0c\u968f\u673a\u5206\u914d\u81f3RDN\u7ec4\u6216\u5047\u624b\u672f\u5bf9\u7167\u7ec4\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c36\u4e2a\u6708\u65f6\uff0cRDN\u7ec4\u7684\u8bca\u5ba4\u6536\u7f29\u538b\u53d8\u5316\u4e3a\uff0d26.4 mmHg(SD\uff1d25.9)\uff0c\u5047\u624b\u672f\u5bf9\u7167\u7ec4\u4e3a\uff0d5.7 mmHg(SD\uff1d24.4)\uff1bRDN\u7ec424 h\u52a8\u6001\u6536\u7f29\u538b\u7684\u53d8\u5316\u4e3a\uff0d15.6 mmHg(SD\uff1d20.8)\uff0c\u5047\u624b\u672f\u5bf9\u7167\u7ec4\u4e3a\uff0d0.3 mmHg(SD\uff1d15.1)\u3002\u5404\u6cbb\u7597\u7ec4\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u76f8\u4f3c\uff0c\u6ca1\u6709\u51fa\u73b0RDN\u665a\u671f\u5e76\u53d1\u75c7\u7684\u8bc1\u636e\u3002SPYRAL HTN-ON MED\u662f\u4e00\u9879\u6982\u5ff5\u9a8c\u8bc1\u8bd5\u9a8c\uff0c\u91c7\u7528\u968f\u673a\u3001\u5047\u624b\u672f\u5bf9\u7167\u7684\u65b9\u6cd5[23]<\/sup>\u3002\u572836\u4e2a\u6708\u65f6\uff0cRDN\u7ec4\u52a8\u6001\u8840\u538b\u76d1\u6d4b\u4e2d\u6536\u7f29\u538b\u964d\u4f4e(18.7\u00b112.4)mmHg\uff0c\u800c\u5047\u624b\u672f\u5bf9\u7167\u7ec4\u964d\u4f4e(8.6\u00b114.6)mmHg\uff1b\u8c03\u6574\u540e\u7684\u6cbb\u7597\u5dee\u5f02\u4e3a\uff0d10.0 mmHg(95%CI\uff1a\uff0d16.6\uff5e\uff0d3.3\uff0cP\uff1d0.003 9)\u3002\u5b89\u5168\u6027\u7ec8\u70b9\u4e8b\u4ef6\u5c11\u89c1\uff0c\u5047\u624b\u672f\u7ec4\u67091\u4f8b\u6b7b\u4ea1\uff0cRDN\u7ec4\u67091\u4f8b\u8111\u5352\u4e2d\u548c\u9ad8\u8840\u538b\u5371\u8c61\uff1b\u6ca1\u6709\u53d1\u751f\u4e0eRDN\u76f8\u5173\u7684\u80be\u52a8\u8109\u72ed\u7a84\u6216\u9700\u8981\u518d\u6b21\u4ecb\u5165\u6cbb\u7597\u5e72\u9884\u7684\u4e8b\u4ef6\u3002\u56e0\u6b64\uff0c\u65b0\u6307\u5357\u5bf9\u4e8e\u6392\u9664\u4e86\u7ee7\u53d1\u6027\u9ad8\u8840\u538b\uff0c\u800c\u4e14\u836f\u7269\u96be\u4ee5\u63a7\u5236\u6216\u836f\u7269\u4f9d\u4ece\u6027\u5dee\u7684\u9ad8\u8840\u538b\u60a3\u8005\uff0c\u5efa\u8bae\u53ef\u4ee5\u8003\u8651\u5f00\u5c55RDN\u3002\u5f53\u7136\u4e5f\u5f3a\u8c03\uff0c\u9700\u8981\u5728\u6709\u4e30\u5bcc\u9ad8\u8840\u538b\u8bca\u6cbb\u7ecf\u9a8c\u3001\u80fd\u591f\u8fdb\u884c\u7ee7\u53d1\u6027\u9ad8\u8840\u538b\u75c5\u56e0\u9274\u522b\u7684\u79d1\u5ba4\u6709\u5e8f\u5f00\u5c55\u3002<\/p>\n PART 04\u5c0f\u7ed3<\/p>\n \u6211\u56fd\u9ad8\u8840\u538b\u4eba\u7fa4\u5e9e\u5927\uff0c\u76ee\u524d\u63a7\u5236\u72b6\u51b5\u4e0d\u4f73\u3002\u800c\u4e14\u9752\u5e74\u4eba\u7fa4\u7684\u9ad8\u8840\u538b\u60a3\u75c5\u60c5\u51b5\u4e5f\u6e10\u663e\u7a81\u51fa\uff0c\u56e0\u6b64\u9ad8\u8840\u538b\u9632\u6cbb\u5c40\u9762\u4ecd\u4e0d\u5bb9\u4e50\u89c2\u3002\u53ca\u65f6\u5c06\u56fd\u5185\u5916\u6700\u65b0\u7814\u7a76\u7ed3\u679c\uff0c\u4ee5\u53ca\u6700\u4f18\u7684\u4e34\u5e8a\u5b9e\u8df5\u548c\u7406\u5ff5\u8fdb\u884c\u66f4\u65b0\uff0c\u5f62\u6210\u65b0\u7684\u6307\u5357\uff0c\u5bf9\u4e8e\u89c4\u8303\u548c\u4f18\u5316\u6211\u56fd\u9ad8\u8840\u538b\u9632\u6cbb\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u5728\u65f6\u96946\u5e74\u540e\u65b0\u6307\u5357\u7684\u53d1\u5e03\u548c\u63a8\u5e7f\uff0c\u5fc5\u5c06\u4e3a\u6307\u5bfc\u6211\u56fd\u9ad8\u8840\u538b\u9632\u6cbb\u5de5\u4f5c\u53d1\u6325\u79ef\u6781\u7684\u4f5c\u7528\u3002<\/p>\n \u53c2\u8003\u6587\u732e<\/p>\n [1] \u4e2d\u56fd\u9ad8\u8840\u538b\u9632\u6cbb\u6307\u5357\u4fee\u8ba2\u59d4\u5458\u4f1a, \u9ad8\u8840\u538b\u8054\u76df(\u4e2d\u56fd), \u4e2d\u56fd\u533b\u7597\u4fdd\u5065\u56fd\u9645\u4ea4\u6d41\u4fc3\u8fdb\u4f1a\u9ad8\u8840\u538b\u75c5\u5b66\u5206\u4f1a, \u7b49. \u4e2d\u56fd\u9ad8\u8840\u538b\u9632\u6cbb\u6307\u5357(2024\u5e74\u4fee\u8ba2\u7248)[J]. \u4e2d\u534e\u9ad8\u8840\u538b\u6742\u5fd7(\u4e2d\u82f1\u6587), 2024, 32(7): 603-700.<\/p>\n [2] \u4e2d\u56fd\u9ad8\u8840\u538b\u9632\u6cbb\u6307\u5357\u4fee\u8ba2\u59d4\u5458\u4f1a, \u9ad8\u8840\u538b\u8054\u76df(\u4e2d\u56fd), \u4e2d\u534e\u533b\u5b66\u4f1a\u5fc3\u8840\u7ba1\u75c5\u5b66\u5206\u4f1a, \u7b49. \u4e2d\u56fd\u9ad8\u8840\u538b\u9632\u6cbb\u6307\u5357(2018\u5e74\u4fee\u8ba2\u7248)[J]. \u4e2d\u56fd\u5fc3\u8840\u7ba1\u6742\u5fd7, 2019, 24(1): 24-56.<\/p>\n [3] \u5f20\u6885, \u5434\u9759, \u5f20\u7b11, \u7b49. 2018\u5e74\u4e2d\u56fd\u6210\u5e74\u5c45\u6c11\u9ad8\u8840\u538b\u60a3\u75c5\u4e0e\u63a7\u5236\u72b6\u51b5\u7814\u7a76[J]. 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Assessment of pazopanib-related hypertension, cardiac dysfunction and identification of clinical risk factors for their development[J]. Cardiooncology, 2017, 3: 5.<\/p>\n [5] \u8096\u7433, \u5357\u5955, \u90b8\u65b0\u535a, \u7b49. 2018\u5e74\u4e2d\u56fd15\u5c81\u53ca\u4ee5\u4e0a\u4eba\u7fa4\u5438\u70df\u73b0\u51b5\u53ca\u53d8\u5316\u8d8b\u52bf\u7814\u7a76[J]. \u4e2d\u534e\u6d41\u884c\u75c5\u5b66\u6742\u5fd7, 2022, 43(6): 811-817.<\/p>\n [6] Li L, Yang A, He X, et al. Indoor air pollution from solid fuels and hypertension: a systematic review and meta-analysis[J]. Environ Pollut, 2020, 259: 113914.<\/p>\n [7] Vinueza Veloz AF, Yaulema Riss AK, De Zeeuw CI, et al. Blood pressure in Andean adults living permanently at different altitudes[J]. High Alt Med Biol, 2020, 21(4): 360-369.<\/p>\n [8] Zhang D, Huang QF, Li Y, et al. A randomized controlled trial on home blood pressure monitoring and quality of care in stage 2 and 3 hypertension[J]. Hypertens Res, 2021, 44(5): 533-540.<\/p>\n [9] Neal B, Wu Y, Feng X, et al. Effect of salt substitution on cardiovascular events and death[J]. N Engl J Med, 2021, 385(12): 1067-1077.<\/p>\n [10] Yuan Y, Jin A, Neal B, et al. Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial[J]. Nat Med, 2023, 29(4): 973-981.<\/p>\n [11] Xu A, Ma J, Guo X,et al. Association of a province-wide intervention with salt intake and hypertension in Shandong province, China, 2011-2016[J]. JAMA Intern Med, 2020, 180(6): 877-886.<\/p>\n [12] Wang Y, Feng L, Zeng G, et al; DECIDE-Diet Study Group. Effects of cuisine-based Chinese heart-healthy diet in lowerin g blood pressure among adults in China: multicenter, single-blind, randomized, parallel controlled feeding trial[J]. Circulation, 2022, 146(4): 303-315.<\/p>\n [13] Wang C, Fu W, Cao S, et al. Association of adiposity indicators with hypertension among Chinese adults[J]. Nutr Metab Cardiovasc Dis, 2021, 31(5): 1391-1400.<\/p>\n [14] \u9648\u795a, \u674e\u82cf\u5b81, \u738b\u99a8, \u7b49. \u6211\u56fd\u4e2d\u5e74\u4eba\u7fa4\u9ad8\u8840\u538b\u3001\u8d85\u91cd\u548c\u80a5\u80d6\u7684\u53d1\u75c5\u7387\u53ca\u5176\u4e0e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u5173\u7cfb[J]. \u4e2d\u534e\u5fc3\u8840\u7ba1\u75c5\u6742\u5fd7, 2020, 48(1): 47-53.<\/p>\n [15] Kritchevsky SB, Beavers KM, Miller ME, et al. Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials[J]. PLoS One, 2015, 10(3): e0121993.<\/p>\n [16] Mackenzie IS, Rogers A, Poulter NR, et al. Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial[J]. Lancet, 2022, 400(10361): 1417-1425.<\/p>\n [17] Zhang W, Zhang J, Yan J, et al. Efficacy and safety of sacubitril\/ allisartan for the treatment of primary hypertension: a phase 3 randomized, double-blind study[J]. J Am Coll Cardiol, 2024, 83(13): Suppl. 1705.<\/p>\n [18] Lin DS, Wang TD, Buranakitjaroen P, et al. Angiotensin receptor neprilysin inhibitor as a novel antihypertensive drug: evidence from Asia and around the globe[J]. J Clin Hypertens (Greenwich), 2021, 23(3): 556-567.<\/p>\n [19] Geng Q, Yan R, Wang Z, et al. Effects of LCZ696 (sacubitril\/valsartan) on blood pressure in patients with hypertension: a meta-analysis of randomized controlled trials[J]. Cardiology, 2020, 145(9): 589-598.<\/p>\n [20] Zhang DY, Cheng YB, Guo QH, et al. Treatment of masked hypertension with a Chinese herbal formula: a randomized, placebo-controlled trial[J]. Circulation, 2020, 142(19): 1821-1830.<\/p>\n [21] Lai X, Dong Z, Wu S, et al. Efficacy and safety of Chinese herbal medicine compared with losartan for mild essential hypertension: a randomized, multicenter, double-blind, noninferiority trial[J]. Circ Cardiovasc Qual Outcomes, 2022, 15(3): e007923.<\/p>\n [22] Bhatt DL, Vaduganathan M, Kandzari DE, et al; SYMPLICITY HTN-3 Steering Committee Investigators. Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomized SYMPLICITY HTN-3 trial[J]. Lancet, 2022, 400(10361): 1405-1416.<\/p>\n [23] Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham controlled trial[J]. Lancet, 2022, 399(10333): 1401-1410.<\/p>\n","protected":false},"excerpt":{"rendered":" \u4e2d\u56fd\u5fc3\u8840\u7ba1\u6742\u5fd72024Chinese Journal of Cardiovasc … \u7ee7\u7eed\u9605\u8bfb