\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u4e0e\u766b\u75eb\uff1a\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u5206\u7c7b\u53ca\u8bca\u65ad\u66f4\u65b0<\/p>\n
\u7518\u4e9a\u97591\uff0c\u674e\u56fd\u82731\uff0c\u5218\u8d851\uff0c\u51af\u78141\uff0c\u9b4f\u5b50\u6db51\uff0c\u9093\u8273\u66251, 2<\/p>\n
1. \u7b2c\u4e00\u9644\u5c5e\u533b\u9662 \u795e\u7ecf\u5185\u79d1\uff08\u9655\u897f 710032\uff09<\/p>\n
2. \u9655\u897f\u897f\u4eac\u766b\u75eb\u8111\u75c5\u7814\u7a76\u6240\uff08\u9655\u897f 710032\uff09<\/p>\n
\u901a\u4fe1\u4f5c\u8005\uff1a\u9093\u8273\u6625\uff0cEmail\uff1ayanchund@fmmu.edu.cn<\/p>\n
\u5f15\u7528\u672c\u6587\uff1a\u7518\u4e9a\u9759, \u674e\u56fd\u8273, \u5218\u8d85, \u51af\u7814, \u9b4f\u5b50\u6db5, \u9093\u8273\u6625. \u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u4e0e\u766b\u75eb\uff1a\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u5206\u7c7b\u53ca\u8bca\u65ad\u66f4\u65b0. \u766b\u75eb\u6742\u5fd7, 2023, 9(1): 33-37. doi: 10.7507\/2096-0247.202209014<\/p>\n
\u6458\u3000\u8981<\/p>\n
\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\uff08Focal cortical dysplasia\uff0cFCD\uff09\u5c5e\u4e8e\u76ae\u8d28\u53d1\u80b2\u7578\u5f62\u7684\u4e00\u79cd\uff0c\u7531\u795e\u7ecf\u5143\u79fb\u884c\u6216\u589e\u6b96\u969c\u788d\u6240\u5bfc\u81f4\uff0c\u662f\u513f\u7ae5\u96be\u6cbb\u6027\u766b\u75eb\u6700\u5e38\u89c1\u7684\u539f\u56e0\u30022011\u5e74\u56fd\u9645\u6297\u766b\u75eb\u8054\u76df\u5bf9FCD\u8fdb\u884c\u4e86\u8be6\u7ec6\u7684\u5206\u7c7b\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e34\u5e8a\u8bca\u65ad\u548c\u7814\u7a76\u3002\u4f46\u968f\u7740\u9057\u4f20\u5b66\u548c\u75c5\u7406\u5b66\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u5b66\u8005\u4eec\u5bf9\u8be5\u5206\u7c7b\u4e0d\u65ad\u8fdb\u884c\u4fee\u8ba2\uff0c\u5e76\u5efa\u8bae\u589e\u52a0\u9057\u4f20\u5b66\u8bca\u65ad\u5185\u5bb9\uff0c\u4ee5\u83b7\u5f97\u57fa\u56e0\u578b-\u8868\u578b\u7684\u7efc\u5408\u8bca\u65ad\u3002\u6b64\u5916FCD\u7684\u8868\u578b\u4ee5\u53ca\u8bca\u6cbb\u65b9\u6848\u4e5f\u5728\u4e0d\u65ad\u7684\u66f4\u65b0\uff0c\u672c\u6587\u5bf9FCD\u5206\u7c7b\u65b9\u6848\u7684\u66f4\u65b0\u4ee5\u53ca\u5176\u53d1\u75c5\u673a\u5236\u3001\u75c5\u7406\u8868\u73b0\u3001\u4e34\u5e8a\u8868\u578b\u3001\u8bca\u65ad\u548c\u6cbb\u7597\u7684\u8fdb\u5c55\u4f5c\u4e00\u7efc\u8ff0\uff0c\u4ee5\u671f\u4e3aFCD\u7684\u89c4\u8303\u8bca\u7597\u63d0\u4f9b\u4e00\u5b9a\u53c2\u8003\u3002<\/p>\n
\u539f\u6587\u94fe\u63a5\uff08\u590d\u5236\u94fe\u63a5\u8fdb\u5165\u7f51\u9875\u6253\u5f00\uff09\uff1a<\/p>\n
http:\/\/www.\/article\/10.7507\/2096-0247.202209014<\/p>\n
\u6b63 \u6587<\/p>\n
1971\u5e74Taylor\u7b49[1]\u5b66\u8005\u62a5\u9053\u4e8610\u4f8b\u63a5\u53d7\u624b\u672f\u6cbb\u7597\u7684\u96be\u6cbb\u6027\u766b\u75eb\u60a3\u8005\uff0c\u8111\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u53ef\u89c1\u9664\u7b2c\u4e00\u5c42\u5916\u7684\u5176\u4ed6\u76ae\u8d28\u6563\u5728\u5927\u800c\u7578\u5f62\u7684\u795e\u7ecf\u5143\uff0c\u4e8e\u662f\u5c06\u5176\u5b9a\u4e49\u4e3a\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\uff08Focal cortical dysplasia\uff0cFCD\uff09\u3002FCD\u5c5e\u4e8e\u76ae\u8d28\u53d1\u80b2\u7578\u5f62\uff08Malformations of cortical development\uff0cMCD\uff09\u7684\u4e00\u79cd\uff0c\u7531\u8111\u76ae\u8d28\u795e\u7ecf\u5143\u79fb\u884c\u969c\u788d\u3001\u7ec6\u80de\u589e\u6b96\u969c\u788d\u6240\u5bfc\u81f4\uff0c\u53ef\u7d2f\u53ca\u5c40\u90e8\u76ae\u8d28\u3001\u591a\u4e2a\u8111\u53f6\u751a\u81f3\u6574\u4e2a\u5927\u8111\u534a\u7403\u3002FCD\u662f\u513f\u7ae5\u96be\u6cbb\u6027\u766b\u75eb\u6700\u5e38\u89c1\u7684\u539f\u56e0\u3002\u5728\u5c40\u7076\u6027\u766b\u75eb\u4e2d\uff0cFCD\u7684\u60a3\u75c5\u7387\u7ea6\u4e3a5%\uff5e25%[2]\u3002\u5728\u766b\u75eb\u5916\u79d1\u4e2d\uff0c\u7ea640%\uff5e50%\u7684\u766b\u75eb\u624b\u672f\u60a3\u513f\u548c20%\u7684\u766b\u75eb\u624b\u672f\u6210\u5e74\u60a3\u8005\u4e3aFCD [3-4]\u3002<\/p>\n
\uff11\u3000\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u7684\u5206\u7c7b\u53ca\u66f4\u65b0<\/p>\n
2004\u5e74\uff0cPalmini\u7b49[5]\u6839\u636e\u662f\u5426\u5b58\u5728\u7578\u5f62\u795e\u7ecf\u5143\u5c06FCD\u5206\u4e3a\u4e24\u7c7b\uff0c\u5373FCD\u2160\u578b\uff08\u65e0\u7578\u5f62\u795e\u7ecf\u5143\uff09\u548cFCD\u2161\u578b\uff08\u6709\u7578\u5f62\u795e\u7ecf\u5143\uff09\u30022011\u5e74\u56fd\u9645\u6297\u766b\u75eb\u8054\u76df\uff08International League Against Epilepsy\uff0cILAE\uff09\u63d0\u51fa\u4e86\u66f4\u52a0\u8be6\u7ec6\u7684\u4e09\u7ea7\u5206\u7c7b\u7cfb\u7edf\uff0c\u5176\u4e2dFCD\u2160\u578b\u5305\u62ec\u5f84\u5411\u5206\u5c42\u7d0a\u4e71\uff08FCD\u2160a\uff09\u3001\u5207\u5411\u5206\u5c42\u7d0a\u4e71\uff08FCD\u2160b\uff09\u548c\u4e24\u79cd\u53d8\u79cd\u7684\u7ec4\u5408\uff08FCD\u2160c\uff09[6]\uff1bFCD\u2161\u9664\u76ae\u8d28\u5206\u5c42\u5f02\u5e38\u5916\u8fd8\u4f34\u6709\u7279\u6b8a\u7ec6\u80de\u5f62\u6001\u5b66\u5f02\u5e38\uff0c\u5305\u62ec\u6709\uff08FCD\u2161b\uff09\u6216\u65e0\u6c14\u7403\u7ec6\u80de\uff08FCD\u2161a\uff09[6]\uff1bFCD\u2162\u578b\u4e0e\u65e9\u671f\u83b7\u5f97\u7684\u81f4\u75eb\u6027\u635f\u5bb3\u6709\u5173\uff0cFCD\u2162a\u548cFCD\u2162b\u578b\u5206\u522b\u4e0e\u6d77\u9a6c\u786c\u5316\u548c\u766b\u75eb\u76f8\u5173\u80bf\u7624\u5408\u5e76\u53d1\u751f\uff0cFCD\u2162c\u578b\u4e0e\u8840\u7ba1\u7578\u5f62\u76f8\u90bb\uff0cFCD\u2162b\u4e0e\u751f\u547d\u65e9\u671f\u83b7\u5f97\u7684\u5176\u4ed6\u4e3b\u8981\u75c5\u53d8\u76f8\u5173 [6]\u3002<\/p>\n
\u867d\u7136ILAE\u66f4\u65b0\u7684FCD\u5206\u7c7b\u65b9\u6848\u88ab\u5e7f\u6cdb\u7528\u4e8e\u4e34\u5e8a\u8bca\u65ad\u548c\u7814\u7a76\uff0c\u4f46\u8be5\u5206\u7c7b\u7cfb\u7edf\u4e3b\u8981\u53d6\u51b3\u4e8e\u75c5\u7406\u7ec4\u7ec7\u7684\u663e\u5fae\u955c\u68c0\u67e5\uff0c\u8bca\u65ad\u65b9\u5f0f\u8f83\u4e3a\u5355\u4e00\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u795e\u7ecf\u5f71\u50cf\u5b66\u548c\u9057\u4f20\u5b66\u6280\u672f\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u5b66\u8005\u4eec\u7ed3\u5408\u65b0\u7684\u6280\u672f\u4e0d\u65ad\u5bf9FCD\u5206\u7c7b\u8fdb\u884c\u4e86\u6539\u5584\uff08\u5bf9\u8fd1\u5e74\u6765FCD\u5206\u7c7b\u7684\u66f4\u65b0\u89c1\u88681\uff09\u30022018\u5e74\uff0c\u6709\u5b66\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u57fa\u4e8e\u7ec4\u7ec7\u75c5\u7406\u5b66\u3001\u5f71\u50cf\u5b66\u548c\u9057\u4f20\u5b66\u7684\u7efc\u5408\u8bca\u65ad\u65b9\u6848\uff0c\u5c06\u9884\u540e\u826f\u597d\u7684\u6c9f\u5e95FCD\u5f52\u7c7b\u4e3aFCD\u2161b\u578b\uff0c\u5e76\u5f15\u5165\u4e86\u56f4\u4ea7\u671f\u7f3a\u8840\u7f3a\u6c27\u6027\u635f\u4f24\u5bfc\u81f4\u7684\u6795\u53f6\u7b2c\u56db\u5c42\u795e\u7ecf\u5143\u4e22\u5931\u8fd9\u4e00\u4e34\u5e8a\u5b9e\u4f53\uff0c\u66f4\u597d\u7684\u5b9a\u4e49\u4e86FCD\u7684\u8868\u578b\u8c31[7-8]\u30022021\u5e74\uff0cBl\u00fcmcke\u7b49[9]\u8bbe\u8ba1\u4e86\u4e00\u9879\u8fed\u4ee3\u7ec4\u7ec7\u75c5\u7406\u5b66\u4e00\u81f4\u6027\u5b9e\u9a8c\uff0c\u4ee5\u9a8c\u8bc12011\u5e74FCD\u5206\u7c7b\u7684\u4e0d\u8db3\u3002\u4ed6\u4eec\u5c06\u8f7b\u5ea6\u76ae\u8d28\u53d1\u80b2\u7578\u5f62\uff08Mild malformations of cortical development\uff0cmMCD\uff09\u4f34\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u589e\u751f\u75c7\uff08Mild malformation of cortical development with oligodendroglial hyperplasia\uff0cMOGHE\uff09\u4e0emMCD\u4f34\u5f02\u4f4d\u795e\u7ecf\u5143\u8fc7\u591a\u5f52\u7c7b\u4e3a\u8111\u767d\u8d28\u75c5\u53d8[9-10]\u3002\u5e76\u786e\u5b9a\u4e86SLC35A2\u57fa\u56e0\u7a81\u53d8\u4e3aMOGHE\u7684\u9057\u4f20\u6807\u8bb0\uff0c7\u4e2amTOR\u9014\u5f84\u7684\u57fa\u56e0\u53d8\u5f02\u4e3aFCD II\u578b\u7684\u9057\u4f20\u6807\u8bb0[10-11]\u3002\u6700\u7ec8Bl\u00fcmcke\u7b49[9]\u5efa\u8bae\u5c06\u9057\u4f20\u5b66\u7ed3\u679c\u5f15\u5165\u5230ILAE\u7684\u5206\u7c7b\u65b9\u6848\u4e2d\uff0c\u4ee5\u83b7\u5f97\u7efc\u5408\u7684\u57fa\u56e0\u578b-\u8868\u578b\u8bca\u65ad\u3002<\/p>\n
\uff12\u3000\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u7684\u53d1\u75c5\u673a\u5236<\/p>\n
\u5728\u80da\u80ce\u53d1\u80b2\u7684\u7b2c8\uff5e24\u5468\uff0c\u672a\u5206\u5316\u7ec6\u80de\u8fdb\u884c\u589e\u6b96\uff0c\u795e\u7ecf\u6bcd\u7ec6\u80de\u8fc1\u79fb\u5e76\u4e14\u5206\u5316\u6210\u4e3a\u795e\u7ecf\u5143\u548c\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de[12]\u3002\u8be5\u65f6\u671f\u4efb\u4e00\u9636\u6bb5\u51fa\u73b0\u969c\u788d\uff0c\u90fd\u4f1a\u5bfc\u81f4\u76ae\u8d28\u53d1\u80b2\u7578\u5f62\u3002<\/p>\n
\u5728\u4eba\u4f53\u5185\uff0c\u96f7\u5e15\u9709\u7d20\u9776\u86cb\u767d\u590d\u5408\u4f53\uff08Mechanistic target of rapamycin\uff0cmTOR\uff09\u6574\u5408\u4e86\u6765\u81ea\u751f\u957f\u56e0\u5b50\u3001\u6fc0\u7d20\u3001\u80fd\u91cf\u72b6\u6001\u7b49\u591a\u79cd\u4fe1\u53f7\u3002\u9996\u5148RAS-MAKP\u3001PI3K-AKT\u3001\u548cAMPK\u9014\u5f84\u6c47\u805a\u6574\u5408\u4e8eTSC1\/TSC2\u590d\u5408\u4f53\uff0c\u800cTSC1\/TSC2\u590d\u5408\u4f53\u53ef\u6291\u5236mTOR\u63a7\u5236\u7ec6\u80de\u7684\u589e\u957f\u548c\u5206\u5316\u3001\u80fd\u91cf\u4ee3\u8c22\u548c\u86cb\u767d\u8d28\u5408\u6210 [13]\u3002\u4e0a\u6e38\u8c03\u8282\u56e0\u5b50\uff08TSC1\u3001TSC2\u3001Strada\u3001PTEN\u6216NF-1\uff09\u3001\u805a\u96c6\u5728TSC1\/2\u901a\u8def\u4e0a\u7684\u7ec4\u4ef6\u548cmTOR\u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4mTOR\u9014\u5f84\u8fc7\u5ea6\u6d3b\u8dc3\uff0c\u4f7f\u7ec6\u80de\u751f\u957f\u548c\u589e\u6b96\u5f02\u5e38\u5e76\u6539\u53d8\u7ec6\u80de\u819c\u7684\u5174\u594b\u6027\u548c\u7a81\u89e6\u7ec4\u7ec7\uff0c\u5bfc\u81f4\u795e\u7ecf\u5143\u5174\u594b\u6027\u589e\u9ad8\u548c\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u7684\u53d1\u751f[13]\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728FCD IIb\u578b\u60a3\u8005\u4e2d\u53d1\u73b0\u4e86\u4eba\u4e73\u5934\u7624\u72b6\u75c5\u6bd216 E6\uff08Human papilloma virus type 16 E6\uff0cHPV E6\uff09\u764c\u86cb\u767d\uff0c\u8be5\u86cb\u767d\u662fmTOR\u4fe1\u53f7\u4f20\u5bfc\u7684\u6709\u6548\u6fc0\u6d3b\u5242[14]\u3002\u52a8\u7269\u5b9e\u9a8c\u8868\u660e\uff0cHPV16 E6\u53ef\u6fc0\u6d3bPDK1\u548cAKT\u4ece\u800c\u6291\u5236TSC1\/2[15]\u3002\u7531DEPDC5\u3001NPRL3\u6216NPRL2\u7ec4\u6210\u7684GATOR1\u86cb\u767d\u590d\u5408\u7269\u4e5f\u6709\u6291\u5236mTOR\u590d\u5408\u7269\u7684\u6d3b\u6027\uff0c\u8be5\u4e09\u79cd\u57fa\u56e0\u7a81\u53d8\u53ef\u5bfc\u81f4mTOR\u8fc7\u5ea6\u6d3b\u8dc3\u800c\u53d1\u751f\u766b\u75eb[16]\u3002<\/p>\n
Giorgi\u7b49[17]\u7814\u7a76\u53d1\u73b0\uff0c\u5728FCD\u3000\u2160a\/\u2162a\u60a3\u8005\u4e2d\uff0c\u03b3-\u6c28\u57fa\u4e01\u9178\uff08\u03b3-aminobutyric acid\uff0cGABA\uff09\u6c28\u57fa\u9178\u80fd\u795e\u7ecf\u5143\u9499\u7ed3\u5408\u86cb\u767d\u8868\u8fbe\u589e\u52a0\u3002FCD\u4f34\u766b\u75eb\u60a3\u8005\u7684\u75c5\u7076\u533aGABA\u6c34\u5e73\u663e\u8457\u9ad8\u4e8e\u5bf9\u4fa7\u533a\uff0c\u4e5f\u63d0\u793aGABA\u53ef\u80fd\u53c2\u4e0e\u4e86FCD\u4f34\u766b\u75eb\u7684\u53d1\u75c5\u673a\u5236[18]\u3002\u6c27\u5316\u5e94\u6fc0\u5728MCD\u81f4\u75eb\u6027\u8111\u7ec4\u7ec7\u4e2d\u5f88\u660e\u663e\uff0c\u5728FCD\u2161\u578b\u60a3\u8005\u4e2d\u4e5f\u6301\u7eed\u5b58\u5728\u6297\u6c27\u5316\u4fe1\u53f7\u7684\u6fc0\u6d3b\u548c\u8c03\u8282\u969c\u788d[19]\u3002<\/p>\n
\uff13\u3000\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u7684\u75c5\u7406\u8868\u73b0<\/p>\n
FCD\u2160\u7684\u7279\u5f81\u662f\u76ae\u8d28\u5206\u5c42\u969c\u788d\uff0c\u7ec4\u7ec7\u7ed3\u6784\u7d0a\u4e71\u3002\u5728FCD\u2160a\u4e2d\u53ef\u89c1\u4e30\u5bcc\u7684\u5fae\u67f1\u72b6\u7ec4\u7ec7\uff0c\u901a\u5e38\u4f34\u6709\u767d\u8d28\u8fb9\u754c\u6a21\u7cca\uff0c\u53ef\u80fd\u4f1a\u51fa\u73b0\u5c0f\u76f4\u5f84\u795e\u7ecf\u5143\u548c\u7b2c5\u5c42\u5916\u80a5\u5927\u7684\u690e\u4f53\u795e\u7ecf\u5143[6]\u3002FCD\u2160b\u5f02\u5e38\u7ec6\u80de\u4e0eFCD\u2160a\u76f8\u540c\uff0c\u6b64\u5916\u8fd8\u4f1a\u51fa\u73b0\u6811\u7a81\u65b9\u5411\u7d0a\u4e71\u7684\u6b63\u5e38\u795e\u7ecf\u5143[6]\u3002FCD\u2161\u9664\u76ae\u8d28\u5206\u5c42\u5f02\u5e38\u5916\u8fd8\u53ef\u4f34\u6709\u7578\u5f62\u795e\u7ecf\u5143\u3002FCD II a\u53ea\u6709\u7578\u5f62\u795e\u7ecf\u5143\u65e0\u6c14\u7403\u6837\u7ec6\u80de\uff0c\u7578\u5f62\u795e\u7ecf\u5143\u53ef\u89c1\u80de\u4f53\u548c\u80de\u6838\u663e\u8457\u589e\u5927\uff0c\u80de\u6d46\u5185\u805a\u96c6\u6709\u5c3c\u6c0f\u7269\u8d28\u548c\u795e\u7ecf\u4e1d\u86cb\u767d[6]\u3002FCD\u2161b\u578b\u9664\u7578\u5f62\u795e\u7ecf\u5143\u5916\u8fd8\u5177\u6709\u7279\u5f81\u6027\u7684\u80de\u6d46\u4e73\u767d\u8272\u7684\u6c14\u7403\u7ec6\u80de[6]\u3002FCD\u2162\u578b\u662f\u4e0e\u4e3b\u8981\u75c5\u53d8\u76f8\u5173\u7684\u76ae\u8d28\u7ed3\u6784\u5f02\u5e38\uff0c\u75c5\u7406\u5b66\u4e3b\u8981\u8868\u73b0\u4e3a\u75c5\u53d8\u5468\u56f4\u7684\u76ae\u8d28\u5206\u5c42\u969c\u788d\u3001\u516d\u5c42\u7ed3\u6784\u7684\u53d1\u80b2\u4e0d\u826f\u548c\u795e\u7ecf\u5143\u80a5\u5927[6]\u3002<\/p>\n
\uff14\u3000\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u7684\u4e34\u5e8a\u8868\u578b<\/p>\n
FCD\u2160\u578b\u662f\u7531\u4e8e\u76ae\u5c42\u7ed3\u6784\u5f62\u6210\u969c\u788d\u6240\u5bfc\u81f4\uff0c\u901a\u5e38\u4e8e\u5a74\u513f\u671f\u6216\u513f\u7ae5\u65e9\u671f\u5373\u51fa\u73b0\u5c40\u7076\u6027\u766b\u75eb\u4f34\u53d1\u80b2\u8fdf\u7f13[20-21]\u3002\u4e14FCD\u2160\u578b\u53d1\u751f\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u503e\u5411\u6bd4FCD\u2161\u578b\u66f4\u52a0\u5f3a\u70c8[22]\u3002\u76f8\u6bd4\u4e8eFCD\u2160b\u578b\uff0cFCD\u2160a\u8d77\u75c5\u665a\u4e14\u75c7\u72b6\u8f7b\uff0c\u4e3b\u8981\u4f4d\u4e8e\u989e\u53f6\uff0c\u4f46FCD\u2160a\u667a\u529b\u6c34\u5e73\u66f4\u4f4e\uff0c\u5bb9\u6613\u51fa\u73b0\u884c\u4e3a\u969c\u788d [21-23]\u3002FCD\u2160\u578bMRI\u591a\u4e3a\u9634\u6027\uff0c\u4ec552%\u7684FCD\u2160a\u60a3\u8005\u300114%\u7684FCD\u2160b\u578b\u60a3\u8005\u53ef\u663e\u793a\u51faFlair\u76f8\u4fe1\u53f7\u7684\u6539\u53d8\uff0c\u5305\u62ec\u7070\u767d\u8d28\u4ea4\u754c\u5904\u6a21\u7cca\u3001\u8f7b\u5fae\u767d\u8d28\u4fe1\u53f7\u6539\u53d8\u548c\u5c40\u7076\u6027\u767d\u8d28\u4f53\u79ef\u7f29\u5c0f[21-23]\u3002\u800c\u5728MRI\u9634\u6027\u7684\u60a3\u8005\u4e2d\uff0c\u6c1f\u8131\u6c27\u8461\u8404\u7cd6\uff08Fluorodeoxyglucose\uff0cFDG\uff09-\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff08Positron emission tomography\uff0cPET\uff09\u7684\u654f\u611f\u5ea6\u53ef\u9ad8\u8fbe78%[24]\u3002\u5728\u6700\u65b0\u5206\u7c7b\u4e2d\uff0cMOGHE\u5c5e\u4e8e\u4e00\u79cd\u72ec\u7acb\u7684\u4e34\u5e8a\u5b9e\u4f53\uff0c\u5176\u5f71\u50cf\u5b66\u8868\u73b0\u968f\u5e74\u9f84\u800c\u8fdb\u884c\u53d8\u5316\uff0c\u57281.5\uff5e5\u5c81\u4e4b\u95f4\uff0c\u60a3\u8005MRI\u901a\u5e38\u8868\u73b0\u4e3a\u76ae\u8d28\u9ad3\u8d28\u4ea4\u754c\u5904T2\u76f8\u548cFLAIR\u76f8\u4fe1\u53f7\u589e\u52a0\uff0c\u57283.5\uff5e20\u5c81\u8868\u73b0\u4e3a\u76ae\u9ad3\u8d28\u5206\u5316\u51cf\u5c11[11-25]\u3002<\/p>\n
FCD\u2161\u578b\u66f4\u5e38\u89c1\u4e8e\u989d\u53f6\uff0c\u8d77\u75c5\u5e74\u9f84\u65e9\u4e8eFCD\u2160\u578b\uff0c\u5e73\u5747\u53d1\u75c5\u5e74\u9f84\u4e3a11\u5c81[26]\u3002FCD\u2161\u901a\u5e38\u766b\u75eb\u53d1\u4f5c\u9891\u7387\u66f4\u9ad8\uff0c\u4e14\u8ba4\u77e5\u969c\u788d\u548c\u795e\u7ecf\u529f\u80fd\u7f3a\u635f\u66f4\u4e3a\u5e38\u89c1[21-27]\u3002\u5176MRI\u8868\u73b0\u4e3a\u76ae\u8d28\u539a\u5ea6\u6539\u53d8\u548c\u7070\u767d\u8d28\u6a21\u7cca\uff0c\u5176\u4e2d FCD\u2161b\u578b\u5b58\u5728\u7279\u5f02\u6027\u7684\u201cTransmantle\u5f81\u201d\uff08\u5373\u4ece\u8111\u56de\u5230\u8111\u5ba4\u5448\u6f0f\u6597\u72b6\u9ad8\u4fe1\u53f7\uff09[23-26]\u3002\u7ea6\u67091\/3\u7684FCD\u2161\u578b\u60a3\u8005\u5f71\u50cf\u5b66\u8868\u73b0\u4e3a\u9634\u6027\uff0c\u4f467.0T MRI\u53ef\u53d1\u73b016%\uff5e32%\u5148\u524d1.5T\u548c3.0TMRI\u9634\u6027\u7684\u60a3\u8005[28]\u3002Bartolini\u7b49[29]\u53d1\u73b07.0T MRI\u53ef\u89c1FCD\u2161\u578b\u76ae\u8d28\u5185\u6709\u4e00\u6761\u7279\u6b8a\u7684\u4f4e\u4fe1\u53f7\u5e26\uff0c\u8be5\u4f4e\u4fe1\u53f7\u5e26\u662f\u5426\u5b8c\u5168\u5207\u9664\u4e0e\u624b\u672f\u7597\u6548\u76f8\u5173\u3002\u6b64\u5916PET\/CT\u4e5f\u80fd\u53d1\u73b0\u5148\u524d\u5f71\u50cf\u5b66\u68c0\u67e5\u672a\u53d1\u73b0\u7684\u7ec6\u5fae\u7684FCD\u75c5\u53d8[30]\u3002\u6795\u53f6FCD\u2161\u578b\u60a3\u8005\u8111\u7535\u56fe\u591a\u6570\u65e0\u660e\u663e\u6539\u53d8\uff0c\u800c\u989e\u53f6FCD\u2161\u53ef\u51fa\u73b0\u8282\u5f8b\u6027\u6162\u6ce2\u548c\u91cd\u590d\u68d8\u6ce2\/\u5c16\u6ce2[31-32]\u3002\u56e0\u6b64\u4f53\u8868\u8111\u7535\u76d1\u6d4b\u7684\u766b\u75eb\u53d1\u4f5c\u6a21\u5f0f\u6709\u52a9\u4e8e\u766b\u75eb\u7076\u7684\u5b9a\u4f4d\u4ee5\u53ca\u672f\u524d\u8bc4\u4f30[32]\u3002<\/p>\n
\u76ee\u524d\u6587\u732e\u5173\u4e8eFCD\u2162\u578b\u60a3\u8005\u7684\u62a5\u9053\u5e76\u4e0d\u591a\u3002FCD\u2162a\u4e0e\u6d77\u9a6c\u786c\u5316\u76f8\u5173\uff0c\u4e3b\u8981\u4e3a\u70ed\u6027\u766b\u75eb\u53d1\u4f5c\uff0c\u8d77\u75c5\u8f83FCD\u2162b\u665a\u4e14\u75c5\u7a0b\u8f83\u77ed[31]\u3002\u7814\u7a76\u8868\u660e\uff0c\u7ea640%\u7684FCD \u2162a\u578b\u766b\u75eb\u53d1\u4f5c\u6765\u81ea\u674f\u4ec1\u6838\/\u6d77\u9a6c\u4f53\u590d\u5408\u4f53\uff0c35%\u6765\u81ea\u989e\u53f6\u65b0\u76ae\u8d28[33]\u3002\u80bf\u7624\u751f\u957f\u7f13\u6162\u7684FCD\u2162b\u60a3\u8005\u7684\u766b\u75eb\u53d1\u751f\u7387\u63a5\u8fd1100%\uff0c\u76ee\u524d\u4ec5\u53d1\u73b0\u4e00\u4f8bFCD\u2162b\u4e0d\u4f34\u766b\u75eb\u53d1\u4f5c\u7684\u60a3\u8005[31-34]\u3002\u603b\u4e4b\uff0cFCD\u2162\u7684\u4e34\u5e8a\u8868\u73b0\u548c\u7535\u4e34\u5e8a\u8868\u73b0\u5c1a\u672a\u786e\u5b9a\uff0c\u4e5f\u7f3a\u4e4f\u533a\u5206FCD\u2162a\u548c\u6d77\u9a6c\u786c\u5316\u4f34\u989e\u53f6\u766b\u75eb\u7684\u5206\u5b50\u6807\u8bb0\u7269\u3002<\/p>\n
\uff15\u3000\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u7684\u8bca\u65ad\u53ca\u6cbb\u7597<\/p>\n
FCD\u662f\u5bfc\u81f4\u513f\u7ae5\u65e9\u671f\u836f\u7269\u96be\u6cbb\u6027\u766b\u75eb\u6700\u91cd\u8981\u7684\u539f\u56e0\u4e4b\u4e00\u3002FCD\u60a3\u8005\u7684\u766b\u75eb\u53d1\u4f5c\u9891\u7387\u4e0d\u7b49\uff0c\u6700\u9ad8\u6bcf\u5929\u53ef\u8fbe\u51e0\u5341\u6b21\uff0c\u4e14\u670932.99%\u7684\u60a3\u8005\u4f1a\u4ea7\u751f\u8010\u836f\u6027\u766b\u75eb[35]\u3002\u76ee\u524dFCD\u7684\u6cbb\u7597\u4e3b\u8981\u5305\u62ec\u766b\u75eb\u6cbb\u7597\u548c\u795e\u7ecf\u529f\u80fd\u969c\u788d\u6cbb\u7597\u3002\u7531\u4e8e\u591a\u8010\u836f\u57fa\u56e0-1\u3001P-\u7cd6\u86cb\u767d\u548c\u591a\u8010\u836f\u76f8\u5173\u86cb\u767d1\u5728\u8111\u7ec4\u7ec7\u4e2d\u8fc7\u5ea6\u8868\u8fbe\uff0c\u4e3b\u7a79\u7abf\u86cb\u767d\u5728\u7578\u5f62\u795e\u7ecf\u5143\u4e2d\u8fc7\u5ea6\u8868\u8fbe\uff0c\u5bfc\u81f432.99%\u7684FCD\u4ea7\u751f\u8010\u836f\u6027\u766b\u75eb[36-37]\u3002\u7ea625%\uff5e33%\u7684\u60a3\u8005\u5bf9\u6297\u766b\u75eb\u836f\u6709\u4e00\u8fc7\u6027\u53cd\u5e94\uff0c\u4e14\u4e3b\u8981\u53d1\u751f\u4e8e\u6cbb\u7597\u7684\u7b2c\u4e00\u5e74[38]\u3002mTOR\u6291\u5236\u5242\u662f\u6cbb\u7597FCD\u766b\u75eb\u53d1\u4f5c\u7684\u4e00\u79cd\u65b0\u7684\u9776\u5411\u6cbb\u7597\u9009\u62e9\u3002FCDII\u578b\u4f7f\u7528mTOR\u6291\u5236\u5242\u897f\u7f57\u83ab\u53f8\u6cbb\u7597\uff0c\u53ef\u4f7f\u5c40\u7076\u6027\u766b\u75eb\u53d1\u4f5c\u7684\u9891\u7387\u4e0b\u964d\u8fd125%\uff0c\u4f46\u6ca1\u6709\u8fbe\u5230\u9884\u5b9a\u7684\u7edf\u8ba1\u5b66\u610f\u4e49[39]\u3002Lortie\u7b49[40]\u62a5\u9053\u4e8628\u4f8bFCD\u60a3\u8005\uff0c\u5176\u4e2d11\u4f8b\u60a3\u8005\u51fa\u73b0\u4e86\u766b\u75eb\u75c9\u631b\uff0c\u7528\u6c28\u5df1\u70ef\u9178\u548cACTH\u8f83\u5bb9\u6613\u63a7\u5236\uff0c1\u4f8b\u60a3\u8005\u836f\u7269\u63a7\u5236\u4e0d\u4f73\u3002\u4e00\u9879Meta\u5206\u6790\u8868\u660eFCD\u4f34\u96be\u6cbb\u6027\u766b\u75eb\u60a3\u8005\u9759\u8109\u6ce8\u5c04\u4e19\u79cd\u7403\u86cb\u767d\u53ef\u660e\u663e\u63a7\u5236\u766b\u75eb\u53d1\u4f5c[25]\u3002\u7531\u4e8e\u4f7f\u7528\u4e19\u79cd\u7403\u86cb\u767d\u7684\u60a3\u8005\u6570\u91cf\u5c11\uff0c\u5176\u6709\u6548\u6027\u4ecd\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u9a8c\u8bc1\u3002\u603b\u4f53\u6765\u8bf4\uff0cFCD\u60a3\u8005\u836f\u7269\u6cbb\u7597\u8fbe\u5230\u63a7\u5236\u766b\u75eb\u53d1\u4f5c\uff0c\u4fdd\u6301\u6b63\u5e38\u53d1\u80b2\u7684\u6982\u7387\u8f83\u4f4e\uff0c\u5e94\u5c3d\u65e9\u8003\u8651\u624b\u672f\u6cbb\u7597[40]\u3002<\/p>\n
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\u7acb\u4f53\u5b9a\u5411\u8111\u7535\u56fe\uff08Stereoelectroencephalography\uff0cSEEG\uff09\u5f15\u5bfc\u4e0b\u5c04\u9891\u70ed\u51dd\uff08Radiofrequency thermocoagulation\uff0cRF-TC\uff09\u6cbb\u7597\u7684FCD\u60a3\u8005\u4e5f\u89c2\u5bdf\u5230\u4e86\u826f\u597d\u7684\u7ed3\u679c\u3002Bourdillon\u7b49 [45]\u7eb3\u5165\u4e86162\u4f8b\u91c7\u7528SEEG\u5f15\u5bfc\u4e0bRF-TC\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u7ed3\u679c25%\u7684\u60a3\u8005\u5728\u672f\u540e2\u4e2a\u6708\u5185\u8fbe\u5230\u65e0\u766b\u75eb\u53d1\u4f5c\uff0c7%\u57281\u5e74\u5185\u65e0\u766b\u75eb\u53d1\u4f5c\u5e76\u4e14\u60a3\u8005\u672f\u540e\u8fbe\u5230Engel \u2160\u7ea7\u7684\u9633\u6027\u9884\u6d4b\u503c\u4e3a93%\u3002\u90ed\u5f3a\u7b49[46]\u62a5\u9053\u4e8622\u4f8bRF-TC\u6cbb\u7597\u7684FCD\u60a3\u8005\uff0c77.3%\u5728\u672f\u540e1\uff5e3\u5e74\u5185\u8fbe\u5230\u4e86Engel \u2160\u7ea7\uff0c\u70ed\u51dd\u8fc7\u7a0b\u4e2d\u6709\u60a3\u8005\u51fa\u73b0\u808c\u529b\u4e0b\u964d\u3001\u8bed\u901f\u51cf\u6162\uff0c\u4f46\u4ec51\u4f8b\u60a3\u8005\u51fa\u73b0\u8f7b\u504f\u762b\u540e\u9057\u75c7\u3002Mirza\u7b49[47]\u4e5f\u62a5\u9053\u4e864\u4f8b\u91c7\u7528RF-TC\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5176\u4e2d3\u4f8b\u672f\u540e\u8fbe\u5230\u65e0\u766b\u75eb\u53d1\u4f5c\uff0c\u4ec51\u4f8b\u4ecd\u6709\u660e\u663e\u766b\u75eb\u53d1\u4f5c\u3002<\/p>\n
\u78c1\u5171\u632f\u5f15\u5bfc\u4e0b\u6fc0\u5149\u95f4\u8d28\u70ed\u7597\uff08Magnetic resonance-guided laser interstitial thermal therapy\uff0cMRgLITT\uff09\u53ef\u4ee5\u5728\u6e29\u5ea6\u63a7\u5236\u4e0b\u5229\u7528\u6fc0\u5149\u7684\u5149\u51dd\u56fa\u548c\u9ad8\u70ed\u6548\u5e94\u7834\u574f\u75c5\u53d8\u95f4\u8d28\u7ec4\u7ec7\uff0c\u8fbe\u5230\u6297\u766b\u75eb\u7684\u4f5c\u7528[48]\u3002Lewis\u7b49[49]\u62a5\u905317\u4f8b\u5c40\u7076\u6027\u76ae\u8d28\u53d1\u80b2\u4e0d\u826f\u60a3\u8005\uff0c\u672f\u540e\u5e73\u5747\u968f\u8bbf16.1\u4e2a\u6708\uff0c\u7ea641%\u8fbe\u5230Engel\u2160\u7ea7\u3002\u76ee\u524d\u4ecd\u9700\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6765\u786e\u5b9aMRgLITT\u7684\u7597\u6548\u3002<\/p>\n
\uff16\u3000\u5c0f\u7ed3\u4e0e\u5c55\u671b<\/p>\n
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\u53c2\u8003\u6587\u732e\u7565\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
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