01<\/p>\n
\u5f15\u8a00<\/p>\n
\u5641\u5511\u70f7\u916e\u7c7b\u6297\u83cc\u836f\u7269\u662f\u4e00\u7c7b\u4eba\u5de5\u5408\u6210\u7684\u6297\u83cc\u836f\u7269\uff0c\u76ee\u524d\u4e3b\u8981\u5305\u62ec\u5229\u5948\u5511\u80fa\u3001\u5eb7\u66ff\u5511\u80fa\u548c\u7279\u5730\u5511\u80fa\u3002\u8fd9\u4e9b\u836f\u7269\u5bf9\u591a\u79cdG \u83cc\u5177\u6709\u6297\u83cc\u4f5c\u7528\uff0c\u5728\u4e34\u5e8a\u4e0a\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u6cbb\u7597\u7531MRSA\u7b49\u8010\u836f\u6027G \u7403\u83cc\u5f15\u8d77\u7684\u5404\u79cd\u611f\u67d3\u3002\u672c\u6587\u5c06\u6bd4\u8f83\u8fd9\u4e09\u8005\u7684\u6297\u83cc\u8c31\u3001\u9002\u5e94\u75c7\u3001\u4e0d\u826f\u53cd\u5e94\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u70b9\u3002<\/p>\n
02<\/p>\n
\u7ed3\u6784\u7279\u70b9<\/p>\n
\u5641\u5511\u70f7\u916e\u7c7b\u6297\u83cc\u836f\u7269\u90fd\u662f\u5168\u4eba\u5de5\u5408\u6210\u7684\u5316\u5b66\u7269\u8d28\u3002\u5229\u5948\u5511\u80fa\u7684\u6c27\u6742\u73af\u662f\u5176\u4e3b\u8981\u7684\u7ed3\u6784\u7279\u5f81\u4e4b\u4e00,\u5b83\u7531\u4e00\u4e2a\u4e94\u5143\u73af\u548c\u4e00\u4e2a\u516d\u5143\u73af\u7ec4\u6210\u3002\u7279\u5730\u5511\u80fa\u662f\u7b2c\u4e8c\u4ee3\u5641\u5511\u70f7\u916e\u7c7b\u6297\u83cc\u836f\u7269\uff0c2014\u5e74\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u78f7\u9178\u7279\u5730\u5511\u80fa\u662f\u4e00\u4e2a\u524d\u836f\uff0c\u5728\u4f53\u5185\u6c34\u89e3\u6210\u4e3a\u7279\u5730\u5511\u80fa\uff0c\u53d1\u6325\u6297\u83cc\u4f5c\u7528\u3002\u5eb7\u66ff\u5511\u80fa2021\u5e74\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u5eb7\u66ff\u5511\u80fa\u5728\u5229\u5948\u5511\u80fa\u7684\u57fa\u7840\u4e0a\u8fdb\u884c\u7ed3\u6784\u6539\u9020\uff0c\u5177\u6709\u201c\u4e09\u6c1f\u975e\u5171\u9762\u201d\u521b\u65b0\u8bbe\u8ba1\u7684\u7ed3\u6784\uff0c\u5728\u4fdd\u7559\u5229\u5948\u5511\u80fa\u7684\u6d3b\u6027\u7684\u540c\u65f6\uff0c\u4f18\u5316\u4e86\u795e\u7ecf\u548c\u8840\u6db2\u7cfb\u7edf\u7684\u6bd2\u6027\uff0c\u5e76\u4e14\u964d\u4f4e\u5bf9\u5355\u80fa\u6c27\u5316\u9176\u7684\u6291\u5236\u4f5c\u7528\uff0c\u63d0\u9ad8\u4e86\u4e34\u5e8a\u4f7f\u7528\u7684\u5b89\u5168\u6027\u3002\u4e09\u4e2a\u836f\u7269\u7684\u5206\u5b50\u7ed3\u6784\u89c1\u4e0b\u56fe\u3002<\/p>\n
03<\/p>\n
\u5242\u578b\u6bd4\u8f83<\/p>\n
\u5229\u5948\u5511\u80fa\u548c\u7279\u5730\u5511\u80fa\u6709\u6ce8\u5c04\u5242\u548c\u53e3\u670d\u5242\u578b\uff0c\u5eb7\u66ff\u5511\u80fa\u53ea\u6709\u53e3\u670d\u5236\u5242\u3002\u8be6\u89c1\u4e0b\u8868\u3002<\/p>\n
\u88681.\u4e09\u79cd\u5641\u5511\u70f7\u916e\u7c7b\u6297\u83cc\u836f\u7269\u5df2\u4e0a\u5e02\u5242\u578b<\/p>\n
04<\/p>\n
\u6297\u83cc\u8c31<\/p>\n
\u5229\u5948\u5511\u80fa\u3001\u5eb7\u66ff\u5511\u80fa\u548c\u7279\u5730\u5511\u80fa\u90fd\u5c5e\u4e8e\u7a84\u8c31\u6297\u83cc\u836f\uff0c\u4e3b\u8981\u5bf9\u591a\u79cdG \u83cc\u5177\u6709\u6297\u83cc\u6d3b\u6027\u3002\u7136\u800c\uff0c\u5b83\u4eec\u5728\u6297\u83cc\u8c31\u4e0a\u5b58\u5728\u4e00\u5b9a\u5dee\u5f02\u3002\u5229\u5948\u5511\u80fa\u4e3b\u8981\u5bf9MRSA\u3001\u80ba\u708e\u94fe\u7403\u83cc\u7b49G \u7403\u83cc\u6709\u6548\uff0c\u4f46\u5bf9\u80a0\u7403\u83cc\u5c5e\u7ec6\u83cc\u7684\u6297\u83cc\u6d3b\u6027\u8f83\u5f31\u3002\u5eb7\u66ff\u5511\u80fa\u5bf9\u9769\u5170\u9633\u6027\u83cc\u5305\u62ec\u8461\u8404\u7403\u83cc\u5c5e\u3001\u94fe\u7403\u83cc\u5c5e\u3001\u80a0\u7403\u83cc\u5c5e\u4ee5\u53ca\u68d2\u72b6\u6746\u83cc\u5c5e\u7b49\u7ec6\u83cc\u5747\u663e\u793a\u4e86\u9ad8\u5ea6\u7684\u6297\u83cc\u6d3b\u6027\uff0c\u5305\u62ec\u8010\u836f\u83cc\u682a\u5982\u7532\u6c27\u897f\u6797\u8010\u836f\u7684\u8461\u8404\u7403\u83cc\uff08MRSA\u3001MRSE\uff09\u3001\u9752\u9709\u7d20\u4e0d\u654f\u611f\u80ba\u708e\u94fe\u7403\u83cc\uff08PISP \u548c PRSP\uff09\u548c\u8010\u4e07\u53e4\u9709\u7d20\u7684\u80a0\u7403\u83cc\uff08VRE\uff09\u3002\u7279\u5730\u5511\u80fa\u5219\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u7531\u8461\u8404\u7403\u83cc\u7b49G \u7403\u83cc\u5f15\u8d77\u7684\u611f\u67d3\uff0c\u5176\u6297\u83cc\u8c31\u540c\u6837\u6bd4\u8f83\u7a84\u3002\u5eb7\u66ff\u5511\u80fa\u548c\u5229\u5948\u5511\u80fa\u5728\u591a\u836f\u8010\u836f\u7684\u7ed3\u6838\u5206\u679d\u6746\u83cc\u548c\u975e\u7ed3\u6838\u5206\u679d\u6746\u83cc\u5177\u6709\u8f83\u597d\u7684\u6297\u83cc\u6d3b\u6027\u3002<\/p>\n
\u88682.\u4f53\u5916\u7814\u7a76\u6bd4\u8f83\u5229\u5948\u5511\u80fa\u548c\u5eb7\u66ff\u5511\u80fa\u7684\u6297\u83cc\u6d3b\u6027<\/p>\n
\u88683.\u4f53\u5916\u7814\u7a76\u6bd4\u8f83\u5229\u5948\u5511\u80fa\u548c\u5eb7\u66ff\u5511\u80fa\u7684\u6297\u83cc\u6d3b\u6027<\/p>\n
05<\/p>\n
\u9002\u5e94\u75c7<\/p>\n
\u5229\u5948\u5511\u80fa\u3001\u5eb7\u66ff\u5511\u80fa\u548c\u7279\u5730\u5511\u80fa\u7684\u9002\u5e94\u75c7\u6709\u6240\u4e0d\u540c\u3002\u4e09\u79cd\u836f\u7269\u7684\u8bf4\u660e\u4e66\u9002\u5e94\u75c7\u6bd4\u8f83\u89c1\u4e0b\u8868\u3002<\/p>\n
06<\/p>\n
\u4e0d\u826f\u53cd\u5e94<\/p>\n
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07<\/p>\n
\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u70b9<\/p>\n
\u5641\u5511\u70f7\u916e\u7c7b\u836f\u7269\u662f\u957fPAE\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u6297\u83cc\u836f\u7269\u3002\u5229\u5948\u5511\u80fa\u3001\u5eb7\u66ff\u5511\u80fa\u548c\u7279\u5730\u5511\u80fa\u5728\u4f53\u5185\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u70b9\u7565\u6709\u4e0d\u540c\u3002\u7279\u5730\u5511\u80fa\u7684\u534a\u8870\u671f\u6bd4\u5229\u5948\u5511\u80fa\u957f\uff0c\u800c\u4e14\u56e0\u4e3a\u6297\u83cc\u6d3b\u6027\u51e0\u4e4e\u662f\u5229\u5948\u5511\u80fa\u76844-16\u500d\uff0c\u56e0\u6b64\u7279\u5730\u5511\u80fa\u53ef\u7f29\u77ed\u6cbb\u7597\u5468\u671f\u53ca\u7ed9\u836f\u6b21\u6570\u3002\u76f8\u5bf9\u4e8e\u5176\u4ed6\u6297MRSA\u836f\u7269\u8fde\u7eed10- 14\u5929\uff0c\u6bcf\u59292\u6b21\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u7279\u5730\u5511\u80fa\u7597\u7a0b\u4e00\u822c\u4ec5\u97006\u5929\uff0c\u6bcf\u59291\u6b21\uff0c\u6bcf\u6b21200mg\uff0c\u4ece\u9759\u8109\u8f93\u6ce8\u6539\u6210\u53e3\u670d\u7279\u5730\u5511\u80fa\u65f6\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u7279\u5730\u5511\u80fa\u591a\u6b21\u7ed9\u836f\u540e\uff0c\u672b\u6b21Cmax26.4 \u03bcg\/mL\uff0cAUC 85.86 \u03bcg\/mL\u00b7h\uff0c\u6297\u83cc\u6d3b\u6027\u4e0e\u6d53\u5ea6\uff0d\u65f6\u95f4\u66f2\u7ebf\u4e0b\u9762\u79ef\uff08AUC\uff09\/MIC\u6bd4\u503c\u6709\u5173\u3002\u5eb7\u66ff\u5511\u80fa\u7684\u8bf4\u660e\u4e66\u7528\u6cd5\u4e3a\u6bcf\u6b21800mg\uff0c\u6bcf12\u5c0f\u65f6\u53e3\u670d\u4e00\u6b21\uff0c\u8bf4\u660e\u4e66\u7597\u7a0b7-14\u5929\uff0c\u5177\u4f53\u9700\u8981\u6839\u636e\u611f\u67d3\u7684\u4e25\u91cd\u7a0b\u5ea6\u5177\u4f53\u8bc4\u4f30\u3002<\/p>\n
08<\/p>\n
\u7ed3\u8bba<\/p>\n
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\u53c2\u8003\u6587\u732e\uff1a<\/p>\n
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[2]Micromedex(172). Truven Health Analytics Inc.,2017[2017-04-03].http:\/\/www..<\/p>\n
[3]JAKSIC B, MARTINELLI G, PEREZ-OTEYZA J, et al. Efficacy and safety of linezolid compared with vancomycin in a randomized, double-blind study of febrile neutropenic patients with cancer. Clin Infect Dis,2006, 42(5):597-607.<\/p>\n
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[5] GOMEZ J, CANOVAS E, BANOS V, et al.Linezolid plus Rifampin as a Salvage Therapy in Prosthetic Joint Infections Treated without Removing the Implant. Antimicrob Agents Chemother,2011, 55(9):4308-4310.<\/p>\n
[6]PAPADOPOULOS A, PLACHOURAS D, GIANNITSIOTI E, et al. Efficacy and tolerability of linezolid in chronic osteomyelitis and prosthetic joint infections: a case-control study. J Chemother,2009, 21(2):165-169.<\/p>\n
[7]LIU C, BAYER A, COSGROVE S E, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis,2011, 52(3):e18-e55.<\/p>\n
[8] KOH W J, KWON O J, GWAK H, et al. Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis. J Antimicrob Chemother,2009, 64(2):388-391.<\/p>\n
[9] MIGLIORI G B, EKER B, RICHARDSON M D, et al. A retrospective TBNET assessment of linezolid safety, tolerability and efficacy in multidrug-resistant tuberculosis. Eur Respir J,2009, 34(2):387-393.<\/p>\n
[10] World Health Organization. Guidelines for the programmatic management of drgu-resistant tuberculosis. Geneva: World Health Organization, 2008.<\/p>\n
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[12]SCHECTER G F, SCOTT C, TRUE L, et al.Linezolid in the treatment of multidrug-resistant tuberculosis. Clin Infect Dis,2010,50(1):49-55.<\/p>\n
[13]Li B, Liu Y, Luo J, Cai Y, Chen M, Wang T. Contezolid, a novel oxazolidinone antibiotic, may improve drug-related thrombocytopenia in clinical antibacterial treatment. Front Pharmacol. 2023 Apr 24;14:1157437.<\/p>\n
[14]Shafiekhani M, Fatemi SA, Hosseini P, Marhemati F, Mohammadi S, Sharifi F, Moorkani Kurde Esfahani Pour A, Sadeghi Habibabad F, Saad Abadi N, Shorafa E, Azadi S. Pharmacokinetic and Pharmacodynamic Considerations of Novel Antibiotic Agents for Pediatric Infections: A Narrative Review. Surg Infect (Larchmt). 2023 Oct;24(8):703-715.<\/p>\n
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