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01# \u534a\u679d\u83b2\u6027\u5473\u5f52\u7ecf\uff1a\u8f9b\u3001\u82e6\uff0c\u5bd2\uff0c\u5f52\u809d\u3001\u80ba\u3001\u80c3\u7ecf\u3002\u529f\u6548\uff1a\u6e05\u70ed\u89e3\u6bd2\u3001\u5316\u7600\u5229\u6c34\u3002\u73b0\u4ee3\u836f\u7406\u7814\u7a76\uff1a\u534a\u679d\u83b2\u9ec4\u916e\u53ef\u6291\u5236\u80f0\u817a\u764c\u7ec6\u80deSTAT3\u4fe1\u53f7\u901a\u8def\uff0c\u964d\u4f4eVEGF\u8868\u8fbe\u963b\u65ad\u80bf\u7624\u8840\u7ba1\u751f\u6210\uff0c\u5e76\u901a\u8fc7\u6fc0\u6d3bBax\/Bcl-2\u901a\u8def\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002\u5b9e\u9a8c\u8bc1\u5b9e\u5176\u80fd\u589e\u5f3a\u5409\u897f\u4ed6\u6ee8\u5316\u7597\u654f\u611f\u6027\uff0c\u6291\u5236\u809d\u8f6c\u79fb\u3002\u4e34\u5e8a\u5e94\u7528\uff1a\u80f0\u817a\u764c\u4f34\u9ec4\u75b8\u8005\uff0c\u914d\u8335\u9648\u3001\u864e\u6756\u3001\u90c1\u91d1\u5229\u80c6\u9000\u9ec4\u3002\u5316\u7597\u540e\u9aa8\u9ad3\u6291\u5236\uff0c\u4f0d\u9ec4\u82aa\u3001\u9e21\u8840\u85e4\u3001\u7d2b\u6cb3\u8f66\u8865\u6c14\u751f\u8840\u3002\u8179\u819c\u8f6c\u79fb\u8179\u6c34\uff0c\u52a0\u6cfd\u6cfb\u3001\u5927\u8179\u76ae\u3001\u9f99\u8475\u5229\u6c34\u6d88\u80c0\u3002\u6ce8\u610f\u70b9\uff1a\u813e\u80c3\u865a\u5f31\u8005\u51cf\u91cf\uff0c\u957f\u671f\u670d\u7528\u9700\u76d1\u6d4b\u80be\u529f\u80fd\u3002<\/p>\n

02# \u767d\u82b1\u86c7\u820c\u8349\u6027\u5473\u5f52\u7ecf\uff1a\u7518\u3001\u6de1\uff0c\u51c9\uff0c\u5f52\u80c3\u3001\u5927\u80a0\u3001\u5c0f\u80a0\u7ecf\u3002\u529f\u6548\uff1a\u6e05\u70ed\u6563\u7600\u3001\u89e3\u6bd2\u6d88\u75c8\u3002\u73b0\u4ee3\u836f\u7406\u7814\u7a76\uff1a\u767d\u82b1\u86c7\u820c\u8349\u591a\u7cd6\u53ef\u8c03\u63a7\u80f0\u817a\u764cHedgehog\u901a\u8def\uff0c\u6291\u5236\u80bf\u7624\u5e72\u7ec6\u80de\u81ea\u6211\u66f4\u65b0\uff0c\u5e76\u80fd\u589e\u5f3aCD8+T\u7ec6\u80de\u80bf\u7624\u6d78\u6da6\u63d0\u5347\u514d\u75ab\u5e94\u7b54\u3002\u4e34\u5e8a\u5e94\u7528\uff1a\u80f0\u817a\u764c\u53d1\u70ed\u75bc\u75db\u8005\uff0c\u914d\u67f4\u80e1\u3001\u5ef6\u80e1\u7d22\u3001\u4e03\u53f6\u83b2\u89e3\u70ed\u9547\u75db\u3002\u5408\u5e76\u7cd6\u5c3f\u75c5\uff0c\u4f0d\u5929\u82b1\u7c89\u3001\u845b\u6839\u3001\u5730\u9aa8\u76ae\u8c03\u8282\u8840\u7cd6\u3002\u672f\u540e\u80a0\u7c98\u8fde\uff0c\u52a0\u7ea2\u85e4\u3001\u8d25\u9171\u8349\u3001\u6843\u4ec1\u901a\u8151\u5316\u7600\u3002\u6ce8\u610f\u70b9\uff1a\u865a\u5bd2\u4f53\u8d28\u9700\u914d\u4f0d\u751f\u59dc\uff0c\u65e5\u7528\u91cf\u4e0d\u8d85\u8fc730\u514b\u3002<\/p>\n

03# \u83aa\u672f\u6027\u5473\u5f52\u7ecf\uff1a\u8f9b\u3001\u82e6\uff0c\u6e29\uff0c\u5f52\u809d\u3001\u813e\u7ecf\u3002\u529f\u6548\uff1a\u7834\u8840\u884c\u6c14\u3001\u6d88\u79ef\u6b62\u75db\u3002\u73b0\u4ee3\u836f\u7406\u7814\u7a76\uff1a\u83aa\u672f\u6cb9\u53ef\u901a\u8fc7\u6291\u5236FAK\/PI3K\u901a\u8def\u963b\u788d\u80f0\u817a\u764c\u7ec6\u80de\u4fb5\u88ad\u8f6c\u79fb\uff0c\u5e76\u8c03\u8282TGF-\u03b21\u6291\u5236\u80bf\u7624\u7ea4\u7ef4\u5316\u8fdb\u7a0b\u3002\u4e34\u5e8a\u5e94\u7528\uff1a\u80f0\u817a\u764c\u8179\u90e8\u5305\u5757\u8005\uff0c\u914d\u4e09\u68f1\u3001\u9cd6\u7532\u3001\u7261\u86ce\u8f6f\u575a\u6563\u7ed3\u3002\u5316\u7597\u81f4\u6d88\u5316\u9053\u53cd\u5e94\uff0c\u4f0d\u59dc\u534a\u590f\u3001\u7802\u4ec1\u3001\u9648\u76ae\u7406\u6c14\u6b62\u5455\u3002\u764c\u6027\u75bc\u75db\uff0c\u52a0\u5f90\u957f\u537f\u3001\u4e5d\u9999\u866b\u3001\u9f20\u5987\u6d3b\u8840\u5b9a\u75db\u3002\u6ce8\u610f\u70b9\uff1a\u6708\u7ecf\u8fc7\u591a\u53ca\u51fa\u8840\u503e\u5411\u8005\u7981\u7528\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u590d\u67e5\u8840\u5c0f\u677f\u3002<\/p>\n

04# \u858f\u82e1\u4ec1\u6027\u5473\u5f52\u7ecf\uff1a\u7518\u3001\u6de1\uff0c\u51c9\uff0c\u5f52\u813e\u3001\u80c3\u3001\u80ba\u7ecf\u3002\u529f\u6548\uff1a\u5065\u813e\u6e17\u6e7f\u3001\u6e05\u70ed\u6392\u8113\u3002\u73b0\u4ee3\u836f\u7406\u7814\u7a76\uff1a\u858f\u82e1\u4ec1\u916f\u53ef\u4e0b\u8c03\u80f0\u817a\u764cKRAS\u86cb\u767d\u8868\u8fbe\uff0c\u963b\u6edeMAPK\u4fe1\u53f7\u4f20\u5bfc\uff0c\u5e76\u901a\u8fc7\u8c03\u63a7miR-200c\u6291\u5236\u4e0a\u76ae\u95f4\u8d28\u8f6c\u5316\u3002\u4e34\u5e8a\u5e94\u7528\uff1a\u80f0\u817a\u764c\u813e\u865a\u6cc4\u6cfb\u8005\uff0c\u914d\u7092\u767d\u672f\u3001\u832f\u82d3\u3001\u5c71\u836f\u5065\u813e\u6b62\u6cfb\u3002\u653e\u5c04\u6027\u80a0\u708e\uff0c\u4f0d\u9a6c\u9f7f\u82cb\u3001\u5730\u6986\u70ad\u3001\u4ed9\u9e64\u8349\u51c9\u8840\u62a4\u819c\u3002\u6076\u75c5\u8d28\u6d88\u7626\uff0c\u52a0\u9ec4\u7cbe\u3001\u5c71\u836f\u3001\u963f\u80f6\u6ecb\u9634\u8865\u865a\u3002\u6ce8\u610f\u70b9\uff1a\u5b55\u5987\u614e\u7528\uff0c\u4fbf\u79d8\u8005\u9700\u914d\u4f0d\u706b\u9ebb\u4ec1\u3002<\/p>\n

05# \u59dc\u9ec4\u6027\u5473\u5f52\u7ecf\uff1a\u8f9b\u3001\u82e6\uff0c\u6e29\uff0c\u5f52\u813e\u3001\u809d\u7ecf\u3002\u529f\u6548\uff1a\u7834\u8840\u884c\u6c14\u3001\u901a\u7ecf\u6b62\u75db\u3002\u73b0\u4ee3\u836f\u7406\u7814\u7a76\uff1a\u59dc\u9ec4\u7d20\u53ef\u6291\u5236\u80f0\u817a\u764cNF-\u03baB\u708e\u75c7\u901a\u8def\uff0c\u964d\u4f4eIL-1\u03b2\u3001COX-2\u8868\u8fbe\uff0c\u5e76\u80fd\u9006\u8f6cABC\u8f6c\u8fd0\u86cb\u767d\u4ecb\u5bfc\u7684\u5316\u7597\u8010\u836f\u3002\u4e34\u5e8a\u5e94\u7528\uff1a\u80f0\u817a\u764c\u8170\u80cc\u653e\u5c04\u75db\u8005\uff0c\u914d\u675c\u4ef2\u3001\u7eed\u65ad\u3001\u5168\u874e\u901a\u7edc\u6b62\u75db\u3002\u5408\u5e76\u9ad8\u8102\u8840\u75c7\uff0c\u4f0d\u5c71\u6942\u3001\u51b3\u660e\u5b50\u3001\u7ede\u80a1\u84dd\u8c03\u8282\u8840\u8102\u3002\u9776\u5411\u6cbb\u7597\u76ae\u75b9\uff0c\u52a0\u767d\u9c9c\u76ae\u3001\u5730\u80a4\u5b50\u3001\u7261\u4e39\u76ae\u51c9\u8840\u6b62\u75d2\u3002\u6ce8\u610f\u70b9\uff1a\u80c6\u9053\u6897\u963b\u8005\u614e\u7528\uff0c\u9700\u76d1\u6d4b\u809d\u529f\u80fd\u53d8\u5316\u3002<\/p>\n

06# \u5c71\u6148\u83c7\u6027\u5473\u5f52\u7ecf\uff1a\u7518\u3001\u5fae\u8f9b\uff0c\u51c9\uff0c\u5f52\u809d\u3001\u813e\u7ecf\u3002\u529f\u6548\uff1a\u5316\u75f0\u6563\u7ed3\u3001\u89e3\u6bd2\u6d88\u80bf\u3002\u73b0\u4ee3\u836f\u7406\u7814\u7a76\uff1a\u5c71\u6148\u83c7\u79cb\u6c34\u4ed9\u78b1\u884d\u751f\u7269\u53ef\u6fc0\u6d3b\u80f0\u817a\u764c\u7ec6\u80dep53\u901a\u8def\uff0c\u8bf1\u5bfcG2\/M\u671f\u963b\u6ede\uff0c\u5e76\u6291\u5236\u8868\u8fbe\u964d\u4f4e\u8f6c\u79fb\u6f5c\u80fd\u3002\u4e34\u5e8a\u5e94\u7528\uff1a\u80f0\u817a\u764c\u9888\u90e8\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u8005\uff0c\u914d\u732b\u722a\u8349\u3001\u590f\u67af\u8349\u3001\u6d59\u8d1d\u6bcd\u6d88\u763f\u6563\u7ed3\u3002\u5316\u7597\u540e\u53e3\u8154\u6e83\u75a1\uff0c\u4f0d\u91d1\u94f6\u82b1\u9732\u542b\u6f31\u3002\u95e8\u9759\u8109\u764c\u6813\uff0c\u52a0\u5730\u9f99\u3001\u6c34\u86ed\u3001\u7a7f\u5c71\u7532\u6d3b\u8840\u901a\u7edc\u3002\u6ce8\u610f\u70b9\uff1a\u4e25\u683c\u63a7\u5236\u5242\u91cf\uff08\u65e5\u7528\u91cf3-6\u514b\uff09\uff0c\u8fc7\u91cf\u53ef\u81f4\u795e\u7ecf\u808c\u8089\u6bd2\u6027\u3002<\/p>\n

07# \u7ede\u80a1\u84dd\u6027\u5473\u5f52\u7ecf\uff1a\u7518\u3001\u82e6\uff0c\u5bd2\uff0c\u5f52\u80ba\u3001\u813e\u3001\u80be\u7ecf\u3002\u529f\u6548\uff1a\u76ca\u6c14\u5065\u813e\u3001\u5316\u75f0\u6b62\u54b3\u3002\u73b0\u4ee3\u836f\u7406\u7814\u7a76\uff1a\u7ede\u80a1\u84dd\u7682\u82f7\u53ef\u901a\u8fc7\u8c03\u8282\u80f0\u817a\u764cAMPK\/mTOR\u901a\u8def\u8bf1\u5bfc\u7ec6\u80de\u81ea\u566c\uff0c\u5e76\u80fd\u63d0\u5347NK\u7ec6\u80de\u6d3b\u6027\u589e\u5f3a\u514d\u75ab\u76d1\u89c6\u529f\u80fd\u3002\u4e34\u5e8a\u5e94\u7528\uff1a\u80f0\u817a\u764c\u6c14\u9634\u4e24\u865a\u8005\uff0c\u914d\u592a\u5b50\u53c2\u3001\u9ea6\u51ac\u3001\u4e94\u5473\u5b50\u76ca\u6c14\u517b\u9634\u3002\u653e\u5316\u7597\u540e\u75b2\u4e4f\uff0c\u4f0d\u523a\u4e94\u52a0\u3001\u7ea2\u666f\u5929\u3001\u7075\u829d\u8865\u6c14\u63d0\u795e\u3002\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u52a0\u9ec4\u8fde\u3001\u82e6\u74dc\u5e72\u3001\u6851\u53f6\u8c03\u63a7\u4ee3\u8c22\u3002\u6ce8\u610f\u70b9\uff1a\u865a\u5bd2\u8bc1\u9700\u914d\u4f0d\u5e72\u59dc\uff0c\u670d\u7528\u6297\u51dd\u836f\u7269\u8005\u614e\u7528\u3002<\/p>\n

08# \u516b\u6708\u672d\u6027\u5473\u5f52\u7ecf\uff1a\u82e6\uff0c\u5e73\uff0c\u5f52\u809d\u3001\u80c3\u7ecf\u3002\u529f\u6548\uff1a\u758f\u809d\u548c\u80c3\u3001\u6d3b\u8840\u6b62\u75db\u3002\u73b0\u4ee3\u836f\u7406\u7814\u7a76\uff1a\u516b\u6708\u672d\u4e09\u841c\u7c7b\u6210\u5206\u53ef\u6291\u5236\u80f0\u817a\u764cWnt\/\u03b2-catenin\u901a\u8def\uff0c\u964d\u4f4ec-Myc\u8868\u8fbe\uff0c\u5e76\u901a\u8fc7ROS\u9014\u5f84\u4fc3\u8fdb\u6c27\u5316\u5e94\u6fc0\u6027\u6b7b\u4ea1\u3002\u4e34\u5e8a\u5e94\u7528\uff1a\u80f0\u817a\u764c\u80c1\u8179\u80c0\u6ee1\u8005\uff0c\u914d\u67f4\u80e1\u3001\u9999\u9644\u3001\u90c1\u91d1\u758f\u809d\u7406\u6c14\u3002\u80c6\u6c41\u6de4\u79ef\u7619\u75d2\uff0c\u4f0d\u8335\u9648\u3001\u8d64\u828d\u3001\u767d\u9c9c\u76ae\u5229\u80c6\u6b62\u75d2\u3002\u60c5\u7eea\u6291\u90c1\uff0c\u52a0\u5408\u6b22\u76ae\u3001\u73ab\u7470\u82b1\u3001\u4f5b\u624b\u89e3\u90c1\u5b89\u795e\u3002\u6ce8\u610f\u70b9\uff1a\u4fbf\u6e8f\u8005\u9700\u914d\u4f0d\u7092\u767d\u672f\uff0c\u957f\u671f\u670d\u7528\u6ce8\u610f\u80c3\u9ecf\u819c\u4fdd\u62a4\u3002<\/p>\n

\u4e2d\u836f\u8fd0\u7528\u9700\u9075\u5faa’\u6276\u6b63\u795b\u90aa’\u539f\u5219\uff0c\u65e9\u671f\u4fa7\u91cd\u6e05\u70ed\u89e3\u6bd2\u914d\u5408\u624b\u672f\uff0c\u4e2d\u671f\u5316\u7600\u6563\u7ed3\u534f\u540c\u653e\u5316\u7597\uff0c\u665a\u671f\u5065\u813e\u8865\u80be\u6539\u5584\u751f\u5b58\u8d28\u91cf\u3002\u7279\u522b\u6ce8\u610f\u80f0\u817a\u89e3\u5256\u4f4d\u7f6e\u6df1\u5728\uff0c\u614e\u7528\u5927\u5242\u91cf\u653b\u4f10\u4e4b\u54c1\uff08\u5982\u7518\u9042\u3001\u82ab\u82b1\uff09\u3002\u6587\u4e2d\u6d89\u53ca\u7834\u8840\u836f\u3001\u6bd2\u6027\u836f\u987b\u7ecf\u4e2d\u533b\u80bf\u7624\u4e13\u79d1\u8bc4\u4f30\uff0c\u914d\u5408\u5f71\u50cf\u5b66\u52a8\u6001\u76d1\u6d4b\u3002\u4e2d\u897f\u533b\u7ed3\u5408\u53ef\u6709\u6548\u7f13\u89e3\u764c\u75db\u3001\u8c03\u8282\u80a0\u9053\u529f\u80fd\uff0c\u4f46\u6839\u6cbb\u6027\u5207\u9664\u3001\u65b0\u578b\u9776\u5411\u6cbb\u7597\u7b49\u4ecd\u662f\u6838\u5fc3\u624b\u6bb5\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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