{"id":51602,"date":"2025-05-14T05:10:29","date_gmt":"2025-05-14T05:10:29","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=51602"},"modified":"2025-05-14T05:10:29","modified_gmt":"2025-05-14T05:10:29","slug":"%e9%80%9f%e5%ad%98%ef%bc%81%e9%aa%a8%e6%9d%be%e8%8d%af%e7%89%a9%e6%b2%bb%e7%96%97-%e5%ae%9e%e7%94%a8%e5%ae%9d%e5%85%b8","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=51602","title":{"rendered":"\u901f\u5b58\uff01\u9aa8\u677e\u836f\u7269\u6cbb\u7597 \u201c\u5b9e\u7528\u5b9d\u5178\u201d"},"content":{"rendered":"

\u9aa8\u8d28\u758f\u677e\u75c7\uff08Osteoporosis, OP\uff09\u4f5c\u4e3a\u6700\u5e38\u89c1\u7684\u9aa8\u9abc\u75be\u75c5\uff0c\u5176\u7279\u5f81\u5728\u4e8e\u9aa8\u91cf\u51cf\u5c11\u53ca\u9aa8\u7ec4\u7ec7\u5fae\u7ed3\u6784\u53d7\u635f\uff0c\u8fdb\u800c\u5f15\u53d1\u9aa8\u8106\u6027\u589e\u52a0\u548c\u9aa8\u6298\u98ce\u9669\u4e0a\u5347\u3002\u968f\u7740\u6211\u56fd\u793e\u4f1a\u8001\u9f84\u5316\u7684\u4e0d\u65ad\u52a0\u5267\uff0c\u9aa8\u8d28\u758f\u677e\u75c7\u7684\u60a3\u75c5\u7387\u663e\u8457\u4e0a\u5347\uff0c\u4f46\u5176\u77e5\u6653\u7387\u3001\u8bca\u65ad\u7387\u548c\u6cbb\u7597\u7387\u5747\u504f\u4f4e\u3002\u9274\u4e8e\u6b64\uff0c\u672c\u6587\u5c06\u5bf9\u9aa8\u8d28\u758f\u677e\u75c7\u7684\u6cbb\u7597\u836f\u7269\u8fdb\u884c\u7cfb\u7edf\u6c47\u603b\uff0c\u4ee5\u671f\u4e3a\u9aa8\u79d1\u5927\u592b\u63d0\u4f9b\u5168\u9762\u800c\u4e13\u4e1a\u7684\u53c2\u8003\u3002<\/p>\n

\u6cbb\u7597\u836f\u7269<\/p>\n

OP\u6cbb\u7597\u836f\u7269\u6309\u7167\u4f5c\u7528\u673a\u5236\u53ef\u5206\u4e3a\u9aa8\u5438\u6536\u6291\u5236\u5242\u3001\u9aa8\u5f62\u6210\u4fc3\u8fdb\u5242\u3001\u53cc\u91cd\u4f5c\u7528\u836f\u7269\u548c\u5176\u4ed6\u673a\u5236\u7c7b\u836f\u7269\u3002<\/p>\n

\u4e00\u3001\u9aa8\u5438\u6536\u6291\u5236\u5242<\/p>\n

1\u3001\u53cc\u81a6\u9178\u76d0\u7c7b<\/p>\n

\u662f\u76ee\u524d\u4e34\u5e8a\u4e0a\u5e94\u7528\u6700\u5e7f\u6cdb\u7684\u6297\u9aa8\u8d28\u758f\u677e\u836f\u7269\u3002\u53cc\u81a6\u9178\u76d0\u662f\u7126\u78f7\u9178\u76d0\u7684\u7a33\u5b9a\u7c7b\u4f3c\u7269\uff0c\u5176\u7279\u5f81\u4e3a\u542b\u6709P-C-P\u57fa\u56e2\uff0c\u4e0e\u9aa8\u9abc\u7f9f\u57fa\u78f7\u7070\u77f3\u5177\u6709\u9ad8\u4eb2\u548c\u529b\uff0c\u80fd\u591f\u7279\u5f02\u6027\u7ed3\u5408\u5230\u9aa8\u91cd\u5efa\u6d3b\u8dc3\u90e8\u4f4d\uff0c\u6291\u5236\u7834\u9aa8\u7ec6\u80de\u529f\u80fd\uff0c\u4ece\u800c\u6291\u5236\u9aa8\u5438\u6536\u3002<\/p>\n

\u2b50\uff081\uff09\u963f\u4ed1\u81a6\u9178\u94a0<\/p>\n

\u6ce8\uff1aNMPA\uff1a\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff0cFDA\uff1a\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff0cGIOP\uff1a\u7cd6\u76ae\u8d28\u6fc0\u7d20\u8bf1\u53d1\u7684\u9aa8\u8d28\u758f\u677e\u75c7<\/p>\n

\u2b50\uff082\uff09\u5511\u6765\u81a6\u9178<\/p>\n

\u2b50\uff083\uff09\u5229\u585e\u81a6\u9178\u94a0<\/p>\n

\u2b50\uff084\uff09\u4f0a\u73ed\u81a6\u9178\u94a0<\/p>\n

\u2b50\uff085\uff09\u7c73\u8bfa\u81a6\u9178<\/p>\n

2\u3001RANKL\u6291\u5236\u5242<\/p>\n

\u2b50\uff081\uff09\u5730\u8212\u5355\u6297\uff1a\u662f\u4e00\u4e2a\u5b8c\u5168\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u4e0e\u4eba\u4f53RANKL\u7ade\u4e89\u6027\u7ed3\u5408\uff0c\u963b\u6b62RANK\u4e0eRANKL\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u6291\u5236RANK\/RANKL\u4fe1\u53f7\u901a\u8def\u3002\u56e0\u6b64\uff0c\u5b83\u80fd\u6291\u5236\u7834\u9aa8\u7ec6\u80de\u7684\u6d3b\u6027\u548c\u5206\u5316\uff0c\u8fdb\u800c\u964d\u4f4e\u9aa8\u5438\u6536\uff0c\u589e\u52a0\u9aa8\u5bc6\u5ea6\uff0c\u6539\u5584\u9aa8\u5f3a\u5ea6\u3002<\/p>\n

3\u3001\u964d\u9499\u7d20<\/p>\n

\u964d\u9499\u7d20\u662f\u7531\u7532\u72b6\u817aC\u7ec6\u80de\u5206\u6ccc\u7684\u4e00\u79cd\u9499\u8c03\u8282\u6fc0\u7d20\u3002\u964d\u9499\u7d20\u7684\u4e3b\u8981\u529f\u80fd\u662f\uff1a\u6291\u5236\u7834\u9aa8\u7ec6\u80de\uff0c\u51cf\u5c11\u9aa8\u9abc\u4e2d\u7684\u9499\u79bb\u5b50\u6d41\u5931\u5230\u8840\u6db2\u4e2d\uff1b\u6291\u5236\u80be\u810f\u4e2d\u9499\u79bb\u5b50\u7684\u91cd\u5438\u6536\uff0c\u4fc3\u8fdb\u9499\u79bb\u5b50\u4ece\u5c3f\u6db2\u4e2d\u6392\u6cc4\uff1b\u6291\u5236\u5c0f\u80a0\u4e2d\u9499\u79bb\u5b50\u7684\u91cd\u5438\u6536\u3002\u964d\u9499\u7d20\u53ef\u4ee5\u6291\u5236\u7834\u9aa8\u7ec6\u80de\u7684\u751f\u7269\u6d3b\u6027\uff0c\u51cf\u5c11\u7834\u9aa8\u7ec6\u80de\u6570\u91cf\u548c\u9aa8\u91cf\u4e22\u5931\uff0c\u5e76\u589e\u52a0\u9aa8\u91cf\u3002\u76ee\u524d\u5e94\u7528\u4e8e\u4e34\u5e8a\u7684\u964d\u9499\u7d20\u5236\u5242\u6709\u9cd7\u9c7c\u964d\u9499\u7d20\u7c7b\u4f3c\u7269\u4f9d\u964d\u9499\u7d20\u548c\u9c91\u964d\u9499\u7d20\u4e24\u79cd\u3002<\/p>\n

\u2b50\uff081\uff09\u4f9d\u964d\u9499\u7d20\u2b50\uff082\uff09\u9c91\u964d\u9499\u7d20<\/p>\n

4\u3001\u9009\u62e9\u6027\u96cc\u6fc0\u7d20\u53d7\u4f53\u8c03\u8282\u5242\uff08SERMs\uff09<\/p>\n

SERMs\u662f\u975e\u7c7b\u56fa\u9187\u836f\u7269\uff0c\u53ef\u4ee5\u4e0e\u96cc\u6fc0\u7d20\u53d7\u4f53\u7ed3\u5408\uff0c\u5728\u4e0d\u540c\u9776\u7ec4\u7ec7\u4e2d\u5bfc\u81f4\u53d7\u4f53\u7684\u7a7a\u95f4\u7ed3\u6784\u53d1\u751f\u6539\u53d8\uff0c\u4ece\u800c\u53d1\u6325\u7c7b\u4f3c\u6216\u62ee\u6297\u96cc\u6fc0\u7d20\u7684\u751f\u7269\u5b66\u6548\u5e94\u3002<\/p>\n

\u2b50\uff081\uff09\u96f7\u6d1b\u6614\u82ac<\/p>\n

5\u3001\u7edd\u7ecf\u6fc0\u7d20\u6cbb\u7597\uff08\u96cc\u6fc0\u7d20\uff09<\/p>\n

\u96cc\u6fc0\u7d20\u662f\u5973\u6027\u5206\u6ccc\u7684\u4e3b\u8981\u6027\u6fc0\u7d20\uff0c\u7edd\u7ecf\u540e\u96cc\u6fc0\u7d20\u7684\u5206\u6ccc\u4f1a\u51cf\u5c11\u3002\u96cc\u6fc0\u7d20\u53ef\u4ee5\u8c03\u8282\u7834\u9aa8\u7ec6\u80de\u7684\u51cb\u4ea1\uff1a\u96cc\u6fc0\u7d20\u4e0e\u96cc\u6fc0\u7d20\u53d7\u4f53\u03b1\u7ed3\u5408\uff0c\u8be5\u53d7\u4f53\u8f6c\u4f4d\u5230\u7ec6\u80de\u6838\u5e76\u7ed3\u5408Fas\u914d\u4f53\uff08Fas ligand, FasL\uff09\u8f6c\u5f55\u4f4d\u70b9\uff0c\u4fc3\u8fdbFasL\u7684\u8f6c\u5f55\uff1b\u968f\u540e\uff0cFasL\u4e0e\u7834\u9aa8\u7ec6\u80de\u524d\u4f53\u8868\u9762\u7684\u53d7\u4f53Fas\u7ed3\u5408\uff0c\u8bf1\u5bfc\u534a\u80f1\u6c28\u9178\u86cb\u767d\u91768\u7684\u88c2\u89e3\uff0c\u4ece\u800c\u4fc3\u8fdb\u7834\u9aa8\u7ec6\u80de\u7684\u51cb\u4ea1\u3002<\/p>\n

\u4e8c\u3001\u9aa8\u5f62\u6210\u4fc3\u8fdb\u5242<\/p>\n

1\u3001\u7532\u72b6\u65c1\u817a\u6fc0\u7d20\u7c7b\u4f3c\u7269<\/p>\n

\u2b50\uff081\uff09\u7279\u7acb\u5e15\u80bd<\/p>\n

\u4e09\u3001\u53cc\u91cd\u4f5c\u7528\u836f\u7269<\/p>\n

1\u3001\u786c\u9aa8\u6291\u7d20\u5355\u514b\u9686\u6297\u4f53<\/p>\n

\u2b50\uff081\uff09\u7f57\u83ab\u4f50\u5355\u6297\uff1a\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u786c\u9aa8\u6291\u7d20\u7684\u6d3b\u6027\uff0c\u62ee\u6297\u5176\u5bf9\u9aa8\u4ee3\u8c22\u7684\u8d1f\u5411\u8c03\u63a7\u4f5c\u7528\uff0c\u5728\u4fc3\u8fdb\u9aa8\u5f62\u6210\u7684\u540c\u65f6\u6291\u5236\u9aa8\u5438\u6536\u3002<\/p>\n<\/p>\n

\u6ce8\uff1aEMA\uff1a\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40<\/p>\n

\u56db\u3001\u5176\u4ed6\u673a\u5236\u7c7b\u4f3c\u7269<\/p>\n

1\u3001\u6d3b\u6027\u7ef4\u751f\u7d20D\u53ca\u5176\u7c7b\u4f3c\u7269<\/p>\n

\u2b50\uff081\uff09\u963f\u6cd5\u9aa8\u5316\u9187\u2b50\uff082\uff09\u9aa8\u5316\u4e09\u9187\u2b50\uff083\uff09\u827e\u5730\u9aa8\u5316\u9187<\/p>\n

2\u3001\u7ef4\u751f\u7d20K\u7c7b<\/p>\n

\u2b50\uff081\uff09\u56db\u70ef\u7532\u8418\u918c\uff1a\u662f\u7ef4\u751f\u7d20K2<\/sub>\u7684\u4e00\u79cd\u540c\u578b\u7269\uff0c\u662f\u7fa7\u5316\u9176\u7684\u8f85\u9176\uff0c\u5728\u03b3-\u7fa7\u57fa\u8c37\u6c28\u9178\u7684\u5f62\u6210\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u03b3-\u7fa7\u57fa\u8c37\u6c28\u9178\u662f\u9aa8\u9499\u7d20\u53d1\u6325\u6b63\u5e38\u751f\u7406\u529f\u80fd\u6240\u5fc5\u9700\u7684\uff0c\u5177\u6709\u63d0\u9ad8\u9aa8\u91cf\u7684\u4f5c\u7528\u3002<\/p>\n

\u6297\u9aa8\u8d28\u758f\u677e\u75c7\u836f\u7269\u8054\u5408\u548c\u5e8f\u8d2f\u6cbb\u7597\u65b9\u6848<\/p>\n

\u9aa8\u8d28\u758f\u677e\u75c7\u5c5e\u4e8e\u60a3\u75c5\u7387\u9ad8\u3001\u5371\u5bb3\u4e25\u91cd\u7684\u6162\u6027\u75be\u75c5\uff0c\u957f\u7a0b\u5e8f\u8d2f\u6cbb\u7597\u662f\u9aa8\u8d28\u758f\u677e\u75c7\u836f\u7269\u6cbb\u7597\u7684\u5fc5\u7531\u4e4b\u8def\uff0c\u79d1\u5b66\u5408\u7406\u7684\u836f\u7269\u8054\u5408\u4e0e\u5e8f\u8d2f\u65b9\u6848\u53ef\u4ee5\u6709\u6548\u589e\u52a0\u9aa8\u5bc6\u5ea6\uff0c\u964d\u4f4e\u9aa8\u6298\u98ce\u9669\u3002<\/p>\n

\uff11\u3001\u8054\u5408\u6cbb\u7597\u65b9\u6848\uff1a\u9499\u5242\u4e0e\u7ef4\u751f\u7d20\uff24\u4f5c\u4e3a\u57fa\u7840\u6cbb\u7597\u836f\u7269\uff0c\u53ef\u4ee5\u4e0e\u9aa8\u5438\u6536\u6291\u5236\u5242\u6216\u9aa8\u5f62\u6210\u4fc3\u8fdb\u5242\u8054\u5408\u4f7f\u7528\uff0c\u4e0d\u5efa\u8bae\u8054\u5408\u4f7f\u7528\u76f8\u540c\u4f5c\u7528\u673a\u5236\u7684\u6297\u9aa8\u8d28\u758f\u677e\u75c7\u836f\u7269\uff1b\u5982\u679c\u4f7f\u7528\u964d\u9499\u7d20\u4ee5\u7f13\u89e3\u75bc\u75db\uff0c\u53ef\u77ed\u671f\u4e0e\u5176\u4ed6\u6297\u9aa8\u8d28\u758f\u677e\u75c7\u836f\u7269\u8054\u5408\u4f7f\u7528\u3002<\/p>\n

\u963f\u4ed1\u81a6\u9178\u94a0\u4e0e\u7279\u7acb\u5e15\u80bd\u8054\u5408\u6cbb\u7597\u7edd\u7ecf\u540e\u9aa8\u8d28\u758f\u677e\u75c7\u60a3\u8005\uff0c\u5e76\u672a\u83b7\u5f97\u8f83\u7279\u7acb\u5e15\u80bd\u5355\u836f\u6cbb\u7597\u66f4\u591a\u83b7\u76ca\uff0c\u4e0d\u5efa\u8bae\u8fd9\u4e24\u7c7b\u836f\u7269\u8054\u5408\u4f7f\u7528\u3002\u7279\u7acb\u5e15\u80bd\u8054\u5408\u5511\u6765\u81a6\u9178\u6216\u5730\u8212\u5355\u6297\u5747\u53ef\u914c\u60c5\u7528\u4e8e\u5355\u836f\u6cbb\u7597\u6548\u679c\u4e0d\u4f73\u7684\u9aa8\u6298\u6781\u9ad8\u98ce\u9669\u60a3\u8005\u3002<\/p>\n

2\u3001\u5e8f\u8d2f\u6cbb\u7597\u65b9\u6848\uff1a\u9aa8\u8d28\u758f\u677e\u75c7\u7684\u957f\u671f\u836f\u7269\u5e8f\u8d2f\u65b9\u6848\u4e0d\u4ec5\u80fd\u6709\u6548\u964d\u4f4e\u9aa8\u6298\u98ce\u9669\uff0c\u800c\u4e14\u6709\u663e\u8457\u7684\u836f\u7269\u7ecf\u6d4e\u5b66\u4ef7\u503c\u3002\u7279\u522b\u662f\u5982\u4e0b\u60c5\u51b5\u8981\u8003\u8651\u836f\u7269\u5e8f\u8d2f\u6cbb\u7597\uff1a\u2460\u67d0\u4e9b\u9aa8\u5438\u6536\u6291\u5236\u5242\u6cbb\u7597\u5931\u6548\u3001\u7597\u7a0b\u8fc7\u957f\u6216\u5b58\u5728\u526f\u4f5c\u7528\u65f6\uff1b\u2461\u9aa8\u5f62\u6210\u4fc3\u8fdb\u5242\uff08\u7532\u72b6\u65c1\u817a\u7d20\u7c7b\u4f3c\u7269\u7b49\uff09\u7684\u63a8\u8350\u7597\u7a0b\u5df2\u5230\uff0c\u4f46\u60a3\u8005\u9aa8\u6298\u98ce\u9669\u4ecd\u9ad8\uff0c\u9700\u540e\u7eed\u7ee7\u7eed\u6cbb\u7597\u8005\uff1b\u2462\u7279\u7acb\u5e15\u80bd\u6216\u5730\u8212\u5355\u6297\u7b49\u77ed\u6548\u4f5c\u7528\u836f\u7269\u505c\u836f\u4e4b\u540e\uff0c\u987b\u7ef4\u6301\u6cbb\u7597\u6548\u679c\u8005\u3002<\/p>\n

\uff08\uff11\uff09\u4e0d\u540c\u4f5c\u7528\u673a\u5236\u836f\u7269\u7684\u5e8f\u8d2f\u6cbb\u7597\uff1a\u5148\u4f7f\u7528\u4fc3\u9aa8\u5f62\u6210\u836f\u7269\uff0c\u518d\u5e8f\u8d2f\u6297\u9aa8\u5438\u6536\u836f\u7269\uff0c\u662f\u76ee\u524d\u8f83\u4e3a\u5408\u9002\u7684\u5e8f\u8d2f\u6cbb\u7597\u6a21\u5f0f\u3002\u5982\u7279\u7acb\u5e15\u80bd\u5e8f\u8d2f\u53cc\u81a6\u9178\u76d0\u6216\u5730\u8212\u5355\u6297\u6cbb\u7597\uff0c\u53ef\u6709\u6548\u589e\u52a0\u9aa8\u5bc6\u5ea6\uff0c\u964d\u4f4e\u9aa8\u6298\u98ce\u9669\u3002<\/p>\n

\uff08\uff12\uff09\u76f8\u540c\u4f5c\u7528\u673a\u5236\u836f\u7269\u7684\u5e8f\u8d2f\u6cbb\u7597\uff1a\u53e3\u670d\u53cc\u81a6\u9178\u76d0\u65e0\u6cd5\u8010\u53d7\u6216\u8005\u6548\u679c\u4e0d\u4f73\u7684\u9aa8\u8d28\u758f\u677e\u75c7\u60a3\u8005\u53ef\u8003\u8651\u5e8f\u8d2f\u6ce8\u5c04\u5236\u5242\u5511\u6765\u81a6\u9178\u6216\u8005\u5730\u8212\u5355\u6297\u6cbb\u7597\u3002<\/p>\n

\u6297\u9aa8\u8d28\u758f\u677e\u75c7\u836f\u7269\u7684\u7597\u7a0b<\/p>\n

1\u3001\u6cbb\u7597\u4f9d\u4ece\u6027<\/p>\n

\u6297\u9aa8\u8d28\u758f\u677e\u75c7\u836f\u7269\u7597\u7a0b\u4e0d\u4ec5\u9700\u8981\u4e2a\u4f53\u5316\uff0c\u4e5f\u5e94\u8be5\u5728\u521d\u8bca\u9aa8\u8d28\u758f\u677e\u75c7\u65f6\u5c31\u5236\u5b9a\u957f\u671f\u751a\u81f3\u8986\u76d6\u5168\u751f\u547d\u5468\u671f\u7684\u9aa8\u6298\u98ce\u9669\u7ba1\u7406\u65b9\u6848\u3002<\/p>\n

\u6240\u6709\u6297\u9aa8\u8d28\u758f\u677e\u836f\u7269\u6cbb\u7597\u81f3\u5c11\u5e94\u575a\u63011\u5e74\uff0c\u5e76\u4e14\u662f\u4f9d\u4ece\u6027\u6709\u4fdd\u8bc1\u76841\u5e74\uff0c\u624d\u80fd\u4f7f\u60a3\u8005\u6700\u5927\u83b7\u76ca\u3002\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0c\u9aa8\u8d28\u758f\u677e\u75c7\u60a3\u8005\u7684\u6cbb\u7597\u4f9d\u4ece\u6027>80%\u80fd\u663e\u8457\u964d\u4f4e\u9aa8\u6298\u53ca\u518d\u53d1\u9aa8\u6298\u98ce\u9669\u3002<\/p>\n

2\u3001\u836f\u7269\u5047\u671f<\/p>\n

\u201c\u957f\u6548\u201d\u6297\u9aa8\u8d28\u758f\u677e\u75c7\u836f\u7269\u4ee5\u53cc\u81a6\u9178\u76d0\u7c7b\u4e3a\u4ee3\u8868\u3002\u53e3\u670d\u53cc\u81a6\u9178\u76d0\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5728\u836f\u7269\u6cbb\u75975\u5e74\u540e\uff0c\u82e5\u9aa8\u6298\u98ce\u9669\u4e0d\u9ad8\uff0c\u53ef\u8003\u8651\u8fdb\u5165\u836f\u7269\u5047\u671f\uff1b\u82e5\u9aa8\u6298\u98ce\u9669\u4ecd\u9ad8\uff0c\u5219\u6cbb\u7597\u53ef\u9002\u5f53\u5ef6\u957f\u81f310\u5e74\uff1b\u5bf9\u4e8e\u6781\u9ad8\u9aa8\u6298\u98ce\u9669\u60a3\u8005\uff0c\u53ef\u4ee5\u914c\u60c5\u5ef6\u957f\u6cbb\u7597\u65f6\u95f4\uff0c\u7136\u540e\u518d\u8003\u8651\u662f\u5426\u8fdb\u5165\u836f\u7269\u5047\u671f\u3002\u5bf9\u4e8e\u9759\u8109\u8f93\u6ce8\u5511\u6765\u81a6\u9178\uff0c\u9ad8\u9aa8\u6298\u98ce\u9669\u60a3\u8005\u53ef\u6cbb\u75973\u5e74\uff0c\u82e5\u9aa8\u6298\u98ce\u9669\u4e0d\u9ad8\uff0c\u53ef\u8003\u8651\u8fdb\u5165\u836f\u7269\u5047\u671f\uff1b\u82e5\u662f\u6781\u9ad8\u9aa8\u6298\u98ce\u9669\u60a3\u8005\uff0c\u53ef\u6301\u7eed\u6cbb\u75976\u5e74\uff0c\u518d\u914c\u60c5\u8003\u8651\u8fdb\u5165\u836f\u7269\u5047\u671f\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/p>\n

[1] \u738b\u9752\u9752. \u539f\u53d1\u6027\u9aa8\u8d28\u758f\u677e\u75c7\u836f\u7269\u6cbb\u7597\u8fdb\u5c55[J]. \u6d59\u6c5f\u533b\u5b66, 2024, 46(07): 673-681.<\/p>\n

[2] \u5f20\u7389, \u6e38\u5982\u65ed, \u5f20\u806a, \u7b49. \u9aa8\u8d28\u758f\u677e\u75c7\u6cbb\u7597\u836f\u7269\u5408\u7406\u5e94\u7528\u4e13\u5bb6\u5171\u8bc6(2023) [J]. \u4e2d\u56fd\u533b\u9662\u836f\u5b66\u6742\u5fd7, 2024, 44(09): 985-1006. DOI:10.13286\/j.1001-5213.2024.09.01.<\/p>\n

[3] \u7ae0\u632f\u6797, \u5cb3\u534e. \u539f\u53d1\u6027\u9aa8\u8d28\u758f\u677e\u75c7\u8bca\u7597\u6307\u5357(2022\u7248)\u8981\u70b9\u89e3\u6790[J]. \u5185\u79d1\u6025\u5371\u91cd\u75c7\u6742\u5fd7, 2024, 30(04): 289-293.<\/p>\n

[4] \u4e2d\u534e\u533b\u5b66\u4f1a\u9aa8\u8d28\u758f\u677e\u548c\u9aa8\u77ff\u76d0\u75be\u75c5\u5206\u4f1a, \u7ae0\u632f\u6797. \u539f\u53d1\u6027\u9aa8\u8d28\u758f\u677e\u75c7\u8bca\u7597\u6307\u5357(2022) [J]. \u4e2d\u56fd\u5168\u79d1\u533b\u5b66, 2023, 26(14): 1671-1691.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u9aa8\u8d28\u758f\u677e\u75c7\uff08Osteoporosis, OP\uff09\u4f5c\u4e3a\u6700\u5e38\u89c1\u7684\u9aa8\u9abc\u75be\u75c5\uff0c\u5176\u7279\u5f81\u5728\u4e8e\u9aa8 … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-51602","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/51602","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=51602"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/51602\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=51602"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=51602"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=51602"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}