{"id":51034,"date":"2025-05-02T05:10:40","date_gmt":"2025-05-02T05:10:40","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=51034"},"modified":"2025-05-02T05:10:40","modified_gmt":"2025-05-02T05:10:40","slug":"%e7%94%9f%e9%85%ae%e9%a5%ae%e9%a3%9f%e4%b8%8d%e6%98%af%e7%a5%9e%ef%bc%8c%e5%8f%af%e5%87%8f%e8%84%82%e4%bd%86%e5%87%8f%e5%af%bf%ef%bc%9f%e4%b8%a4%e9%a1%b9%e7%a0%94%e7%a9%b6%e8%af%81%e6%98%8e%ef%bc%9a","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=51034","title":{"rendered":"\u751f\u916e\u996e\u98df\u4e0d\u662f\u795e\uff0c\u53ef\u51cf\u8102\u4f46\u51cf\u5bff\uff1f\u4e24\u9879\u7814\u7a76\u8bc1\u660e\uff1a\u751f\u916e\u996e\u98df\u80fd\u6709\u6548\u51cf\u8102\uff0c\u4f46\u4f1a\u5bfc\u81f4\u8461\u8404\u7cd6\u8010\u91cf\u3001\u7a7a\u8179\u8840\u7cd6\u7b49\u6307\u6807\u53d8\u5dee\uff0c\u4e14\u957f\u671f\u751f\u916e\u4f1a\u52a0\u901f\u8870\u8001"},"content":{"rendered":"

\u5728\u65e5\u76ca\u76db\u884c\u7684\u201c\u8eab\u6750\u7ba1\u7406\u201d\u6f6e\u6d41\u4e0b\uff0c\u51cf\u80a5\u6210\u4e86\u8bb8\u591a\u4eba\u7684\u65e5\u5e38\uff0c\u4e0d\u8bba\u662f\u80d6\u662f\u7626\uff0c\u51cf\u80a5\u90fd\u53d8\u6210\u4e86\u4eba\u4eec\u6302\u5728\u5634\u8fb9\u7684\u70ed\u95e8\u8bdd\u9898\u3002\u800c\u5728\u4e94\u82b1\u516b\u95e8\u7684\u51cf\u80a5\u65b9\u6cd5\u91cc\u9762\uff0c\u751f\u916e\u996e\u98df\u6cd5\u4e00\u76f4\u662f\u5907\u53d7\u8ffd\u6367\u3002\u4e0d\u540c\u4e8e\u5927\u591a\u6570\u63a7\u5236\u70ed\u91cf\u7684\u65b9\u6cd5\uff0c\u751f\u916e\u996e\u98df\u662f\u6307\u91c7\u53d6\u9ad8\u8102\u80aa\u9ad8\u86cb\u767d\u4f46\u6781\u4f4e\u78b3\u6c34\u5316\u5408\u7269\u542b\u91cf\u7684\u81b3\u98df\u6a21\u5f0f\uff0c\u901a\u8fc7\u916e\u4f53\u4f9b\u80fd\u4ee3\u66ff\u8461\u8404\u7cd6\uff0c\u51cf\u5c11\u80f0\u5c9b\u7d20\u5206\u6ccc\uff0c\u4ece\u800c\u964d\u4f4e\u98df\u6b32\u3002<\/p>\n

\u4f46\u662f\uff01\u8fd9\u79cd\u770b\u4f3c\u201c\u65e0\u75db\u201d\u7684\u51cf\u80a5\u65b9\u6cd5\uff0c\u771f\u7684\u201c\u65e0\u75db\u201d\u5417\uff1f\u867d\u7136\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4ee5\u8ba9\u4f60\u514d\u53d7\u8282\u98df\u548c\u8fd0\u52a8\u7684\u75db\u82e6\uff0c\u4f46\u662f\uff0c\u5b83\u5bf9\u8eab\u4f53\u9020\u6210\u7684\u201c\u75db\u201d\u5374\u662f\u4e0d\u53ef\u907f\u514d\u7684\u3002\u76ee\u524d\uff0c\u5df2\u6709\u8bb8\u591a\u7814\u7a76\u6307\u51fa\u4e86\u751f\u916e\u996e\u98df\u7684\u526f\u4f5c\u7528\uff0c\u5305\u62ec\u80be\u529f\u80fd\u51cf\u9000\u3001\u5fc3\u810f\u8d1f\u62c5\u589e\u52a0\u7b49\u7b49\u3002<\/p>\n

\u800c\u5728\u6700\u65b0\u7684\u4e24\u7bc7\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u751f\u916e\u996e\u98df\u4f1a\u5bfc\u81f4\u8461\u8404\u7cd6\u8010\u91cf\u3001\u7a7a\u8179\u8840\u7cd6\u6307\u6807\u53d8\u5dee\u3001\u8eab\u4f53\u4ee3\u8c22\u53d8\u6162\uff0c\u5e76\u4e14\u957f\u671f\u751f\u916e\u996e\u98df\u4f1a\u8bf1\u5bfc\u7ec6\u80de\u8870\u8001\uff01<\/p>\n

\u751f\u916e\u996e\u98df\u5bf9\u8eab\u4f53\u7684\u6539\u9020\u66f4\u4e3a\u201c\u7c97\u66b4\u201d<\/p>\n

\u5728\u4e00\u9879\u6700\u65b0\u7684\u968f\u673a\u5bf9\u7167\u5b9e\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u6df1\u5165\u5206\u6790\u4e86\u751f\u916e\u996e\u98df\u4e0e\u5355\u7eaf\u9650\u5236\u81ea\u7531\u7cd6\u6444\u5165\u5bf9\u5065\u5eb7\u6210\u5e74\u4eba\u7684\u8461\u8404\u7cd6\u8010\u53d7\u6027\u3001\u8102\u8d28\u4ee3\u8c22\u3001\u5916\u5468\u7ec4\u7ec7\u8868\u578b\u548c\u80a0\u9053\u83cc\u7fa4\u7684\u5f71\u54cd\u3002\u8be5\u6210\u679c\u53d1\u8868\u5728Cell Reports Medicine\u4e0a\uff0c\u9898\u4e3a\u201cKetogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT\u201d\u3002<\/p>\n<\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u65e0\u8bba\u662f\u9650\u5236\u81ea\u7531\u7cd6\u6444\u5165\uff08\u6307\u98df\u54c1\u548c\u996e\u6599\u4e2d\u6dfb\u52a0\u7684\u5355\u7cd6\u548c\u53cc\u7cd6\uff0c\u4ee5\u53ca\u5929\u7136\u5b58\u5728\u4e8e\u8702\u871c\u3001\u7cd6\u6d46\u548c\u679c\u6c41\u4e2d\u7684\u7cd6\uff09\u8fd8\u662f\u751f\u916e\u996e\u98df\uff0c\u90fd\u6ca1\u6709\u663e\u8457\u6539\u53d8\u53c2\u4e0e\u8005\u7684\u4f53\u529b\u6d3b\u52a8\u80fd\u91cf\u6d88\u8017\uff08PAEE\uff09\u6216\u5176\u5b83\u80fd\u91cf\u6d88\u8017\u7ec4\u6210\u90e8\u5206\u3002\u5176\u6b21\uff0c\u4e0e\u4e2d\u7b49\u81ea\u7531\u7cd6\u6444\u5165\u7ec4\uff08MODSUG\uff09\u76f8\u6bd4\uff0c\u9650\u5236\u81ea\u7531\u7cd6\u6444\u5165\u7ec4\uff08LOWSUG\uff09\u548c\u751f\u916e\u996e\u98df\u7ec4\uff08LOWCHO\uff09\u7684\u53c2\u4e0e\u8005\u5728\u7b2c4\u5468\u548c\u7b2c12\u5468\u7684\u4f53\u91cd\u548c\u4f53\u8102\u5747\u6709\u6240\u51cf\u5c11\u3002\u8fd9\u8868\u660e\uff0c\u65e0\u8bba\u662f\u901a\u8fc7\u9650\u5236\u7cd6\u6444\u5165\u8fd8\u662f\u91c7\u7528\u751f\u916e\u996e\u98df\uff0c\u53ea\u8981\u603b\u4f53\u80fd\u91cf\u6444\u5165\u51cf\u5c11\u4e86\uff0c\u5c31\u80fd\u89c2\u5bdf\u5230\u4f53\u91cd\u548c\u4f53\u8102\u7684\u4e0b\u964d\u3002<\/p>\n

\u56fe1. \u8eab\u4f53\u6d3b\u52a8\u3001\u4f53\u91cd\u548c\u7ec4\u6210\u7684\u53d8\u5316\u4ee5\u53ca\u80fd\u91cf\u6444\u5165<\/p>\n

\u5c3d\u7ba1\u4e24\u79cd\u996e\u98df\u9650\u5236\u90fd\u80fd\u901a\u8fc7\u51cf\u5c11\u80fd\u91cf\u6444\u5165\u6765\u51cf\u5c11\u4f53\u91cd\u548c\u4f53\u8102\uff0c\u4f46\u5b83\u4eec\u5bf9\u4ee3\u8c22\u5065\u5eb7\u7684\u5f71\u54cd\u5374\u4e0d\u540c\uff1a<\/p>\n

1. \u8840\u7cd6\u8c03\u8282\u673a\u5236\uff1a<\/p>\n

\u25cf \u5728\u751f\u916e\u996e\u98df\u7ec4\u4e2d\uff0c\u7b2c4\u5468\u65f6\u89c2\u5bdf\u5230\u4e86\u7a7a\u8179\u8840\u7cd6\u6c34\u5e73\u7684\u964d\u4f4e\uff0c\u4f46\u540c\u65f6\u9910\u540e\u8840\u7cd6\u53cd\u5e94\u589e\u52a0\u3002\u8fd9\u8868\u660e\u751f\u916e\u996e\u98df\u53ef\u80fd\u4f1a\u7ed9\u80f0\u5c9b\u03b2\u7ec6\u80de\u5e26\u6765\u989d\u5916\u7684\u538b\u529b\uff0c\u957f\u8fdc\u6765\u770b\uff0c\u53ef\u80fd\u524a\u5f31\u8eab\u4f53\u7684\u8840\u7cd6\u8c03\u8282\u80fd\u529b\uff0c\u589e\u52a0\u7f79\u60a32\u578b\u7cd6\u5c3f\u75c5\u7684\u98ce\u9669\u3002<\/p>\n

\u25cf \u76f8\u8f83\u4e4b\u4e0b\uff0c\u9650\u5236\u81ea\u7531\u7cd6\u6444\u5165\u5bf9\u8840\u7cd6\u548c\u80f0\u5c9b\u7d20\u53cd\u5e94\u7684\u5f71\u54cd\u8f83\u4e3a\u6e29\u548c\uff0c\u672a\u5f15\u53d1\u663e\u8457\u7684\u4ee3\u8c22\u6ce2\u52a8\uff0c\u663e\u793a\u4e86\u5bf9\u8840\u7cd6\u7a33\u6001\u7684\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n

2. \u8840\u8102\u4e0e\u5fc3\u8840\u7ba1\u5065\u5eb7\uff1a<\/p>\n

\u25cf \u751f\u916e\u996e\u98df\u5728\u77ed\u671f\u8bd5\u9a8c\u671f\u95f4\u63d0\u5347\u4e86\u8f7d\u8102\u86cb\u767dB\uff08apoB\uff09\u548c\u9910\u540e\u7518\u6cb9\u4e09\u916f\uff08TAG\uff09\u7684\u6d53\u5ea6\uff0c\u4f46\u8fd9\u79cd\u5f71\u54cd\u5728\u7b2c12\u5468\u540e\u9010\u6e10\u51cf\u5f31\u3002\u7136\u800c\uff0c\u957f\u671f\u7684\u9ad8\u8102\u80aa\u6444\u5165\u53ef\u80fd\u4f9d\u7136\u5bf9\u5fc3\u8840\u7ba1\u7cfb\u7edf\u6784\u6210\u9690\u5fe7\uff0c\u589e\u52a0\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98ce\u9669\u3002<\/p>\n

\u25cf \u53cd\u89c2\u9650\u5236\u81ea\u7531\u7cd6\u6444\u5165\u7684\u53c2\u4e0e\u8005\uff0c\u4ed6\u4eec\u5728\u6574\u4e2a\u8bd5\u9a8c\u8fc7\u7a0b\u4e2dLDL\u80c6\u56fa\u9187\uff08\u5373\u201c\u574f\u80c6\u56fa\u9187\u201d\uff09\u6c34\u5e73\u6301\u7eed\u964d\u4f4e\uff0c\u8fd9\u8868\u660e\u8be5\u996e\u98df\u7b56\u7565\u53ef\u80fd\u6709\u52a9\u4e8e\u5fc3\u8840\u7ba1\u7cfb\u7edf\u7684\u5065\u5eb7\u7ef4\u62a4\uff0c\u51cf\u5c11\u52a8\u8109\u786c\u5316\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<\/p>\n

\u56fe2. \u9650\u5236\u81ea\u7531\u7cd6\u6444\u5165\u4e0e\u751f\u916e\u996e\u98df\u540e\u7684\u4ee3\u8c22\u53c2\u6570\u53d8\u5316<\/p>\n

3. \u80a0\u9053\u5fae\u751f\u7269\u7fa4\u843d\uff1a<\/p>\n

\u25cf \u751f\u916e\u996e\u98df\u5728\u7b2c12\u5468\u65f6\u663e\u8457\u6539\u53d8\u4e86\u80a0\u9053\u5fae\u751f\u7269\u7684\u03b2\u591a\u6837\u6027\uff0c\u5c24\u5176\u662f\u964d\u4f4e\u4e86\u53cc\u6b67\u6746\u83cc\uff08Bifidobacterium\uff09\u7684\u76f8\u5bf9\u4e30\u5ea6\uff0c\u8fd9\u4e00\u53d8\u5316\u53ef\u80fd\u4e0e\u8102\u86cb\u767d\u7684\u5f02\u5e38\u6709\u5173\uff0c\u6697\u793a\u751f\u916e\u996e\u98df\u53ef\u80fd\u5bf9\u80a0\u9053\u5065\u5eb7\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\u3002<\/p>\n

\u25cf \u800c\u9650\u5236\u81ea\u7531\u7cd6\u6444\u5165\u5bf9\u80a0\u9053\u83cc\u7fa4\u7684\u5f71\u54cd\u76f8\u5bf9\u8f83\u5c0f\uff0c\u4fdd\u6301\u4e86\u80a0\u9053\u751f\u6001\u7684\u76f8\u5bf9\u7a33\u5b9a\u3002<\/p>\n

4. \u808c\u8089\u548c\u8102\u80aa\u7ec4\u7ec7\u7684\u4ee3\u8c22\uff1a<\/p>\n

\u25cf \u751f\u916e\u996e\u98df\u589e\u52a0\u4e86\u9aa8\u9abc\u808c\u4e2d\u7684PDK4\u86cb\u767d\u6c34\u5e73\uff0c\u540c\u65f6\u964d\u4f4e\u4e86AMPK\u3001GLUT4\u548c\u80f0\u5c9b\u7d20\u53d7\u4f53\u6c34\u5e73\uff0c\u8fd9\u4e9b\u53d8\u5316\u53ef\u80fd\u89e3\u91ca\u4e86\u4e3a\u4f55\u751f\u916e\u996e\u98df\u4f1a\u964d\u4f4e\u8461\u8404\u7cd6\u8010\u53d7\u6027\uff0c\u8868\u660e\u8be5\u996e\u98df\u6a21\u5f0f\u53ef\u80fd\u5e72\u6270\u808c\u8089\u7684\u6b63\u5e38\u4ee3\u8c22\u8fc7\u7a0b\u3002\u6b64\u5916\uff0c\u751f\u916e\u996e\u98df\u8fd8\u6539\u53d8\u4e86\u8102\u80aa\u7ec4\u7ec7\u4e2d\u5173\u952e\u4ee3\u8c22\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u5982\u8102\u86cb\u767d\u9176\uff08LPL\uff09\u548c\u8102\u8054\u7d20\uff08Adiponectin\uff09\uff0c\u8fd9\u53ef\u80fd\u5f71\u54cd\u8102\u80aa\u7684\u5b58\u50a8\u548c\u5229\u7528\u3002<\/p>\n

\u25cf \u76f8\u53cd\uff0c\u9650\u5236\u81ea\u7531\u7cd6\u6444\u5165\u589e\u52a0\u4e86\u808c\u8089\u7cd6\u539f\u6d53\u5ea6\uff0c\u5bf9\u808c\u8089\u7ec4\u7ec7\u5177\u6709\u79ef\u6781\u7684\u4ee3\u8c22\u5f71\u54cd\u3002<\/p>\n

5. \u5185\u5206\u6ccc\u4e0e\u884c\u4e3a\u53cd\u5e94\uff1a<\/p>\n

\u25cf \u9650\u5236\u81ea\u7531\u7cd6\u6444\u5165\u964d\u4f4e\u4e86\u7a7a\u8179\u7626\u7d20\u6d53\u5ea6\uff0c\u800c\u751f\u916e\u996e\u98df\u964d\u4f4e\u4e86\u7a7a\u8179\u548c\u9910\u540eFGF21\u6d53\u5ea6\uff0c\u540c\u65f6\u589e\u52a0\u4e86\u7a7a\u8179GLP-1\u6d53\u5ea6\u3002\u8fd9\u4e24\u79cd\u996e\u98df\u65b9\u5f0f\u4f3c\u4e4e\u90fd\u589e\u52a0\u4e86\u673a\u4f53\u5bf9\u751c\u98df\u7684\u6e34\u671b\uff0c\u8fd9\u53ef\u80fd\u4e0e\u7626\u7d20\u548cFGF21\u6d53\u5ea6\u7684\u4e0b\u964d\u6709\u5173\uff0c\u63d0\u793a\u4e86\u996e\u98df\u5e72\u9884\u53ef\u80fd\u5bf9\u98df\u6b32\u8c03\u8282\u6fc0\u7d20\u4ea7\u751f\u8f83\u5927\u7684\u5f71\u54cd\u53ca\u6ce2\u52a8\u3002<\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u751f\u916e\u996e\u98df\u867d\u80fd\u6709\u6548\u51cf\u8f7b\u4f53\u91cd\u548c\u4f53\u8102\uff0c\u4f46\u5176\u4ee3\u8c22\u6548\u5e94\u66f4\u4e3a\u590d\u6742\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u964d\u4f4e\u8461\u8404\u7cd6\u8010\u53d7\u6027\u3001\u589e\u52a0\u8102\u80aa\u6c27\u5316\u3001\u6539\u53d8\u80a0\u9053\u83cc\u7fa4\u591a\u6837\u6027\u548c\u5f71\u54cd\u808c\u8089\u4e0e\u8102\u80aa\u7ec4\u7ec7\u7684\u4ee3\u8c22\u57fa\u56e0\u8868\u8fbe\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u9650\u5236\u81ea\u7531\u7cd6\u6444\u5165\u5728\u7ef4\u6301\u8840\u7cd6\u7a33\u6001\u3001\u6539\u5584\u8840\u8102\u72b6\u51b5\u548c\u4fdd\u62a4\u5fc3\u8840\u7ba1\u5065\u5eb7\u65b9\u9762\u5c55\u73b0\u51fa\u66f4\u4e3a\u6e29\u548c\u4e14\u6709\u76ca\u7684\u6548\u679c\u3002<\/p>\n

\u957f\u671f\u751f\u916e\u996e\u98df\u4f1a\u8bf1\u5bfc\u7ec6\u80de\u8870\u8001<\/p>\n

\u5728\u53e6\u4e00\u7bc7Science Advances\u7684\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u6df1\u5165\u63a2\u8ba8\u4e86\u751f\u916e\u996e\u98df\u5bf9\u5c0f\u9f20\u5668\u5b98\u7ec6\u80de\u8870\u8001\u7684\u5f71\u54cd\uff0c\u5e76\u9610\u660e\u4e86\u76f8\u5173\u7684\u5206\u5b50\u673a\u5236\u3002\u8be5\u6587\u7ae0\u7531David Gius\u56e2\u961f\u53d1\u8868\uff0c\u9898\u4e3a\u201cKetogenic diet induces p53-dependent cellular senescence in multiple organs\u201d\u3002<\/p>\n<\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u65e0\u8bba\u662f\u6d3b\u529b\u5145\u6c9b\u7684\u5e74\u8f7b\u5c0f\u9f20\uff0c\u8fd8\u662f\u6b65\u5165\u8001\u5e74\u7684\u540c\u4f34\uff0c\u5728\u7ecf\u5386\u4e86\u751f\u916e\u996e\u98df\u7684\u4e0d\u540c\u9636\u6bb5\u540e\uff0c\u5b83\u4eec\u7684\u5fc3\u810f\u3001\u80be\u810f\u3001\u809d\u810f\u4e43\u81f3\u5927\u8111\u7b49\u5173\u952e\u5668\u5b98\u4e2d\uff0c\u7ec6\u80de\u8870\u8001\u7684\u8ff9\u8c61\u53d8\u5f97\u5c24\u4e3a\u660e\u663e\u3002\u4e00\u4e2a\u663e\u8457\u7684\u8870\u8001\u6307\u6807\u2014\u2014SA-\u03b2-gal\u9176\u6d3b\u6027\u88ab\u5e7f\u6cdb\u68c0\u6d4b\u5230\u3002<\/p>\n<\/p>\n

\u56fe3. \u751f\u916e\u996e\u98df\u8bf1\u5bfc\u7684\u7ec6\u80de\u8870\u8001<\/p>\n

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p53\u86cb\u767d\u79ef\u7d2f\u7684\u5965\u79d8\u5728\u4e8ecaspase-2\u9176\u7684\u6fc0\u6d3b\uff0c\u5b83\u50ac\u5316\u4e86MDM2\u86cb\u767d\u7684\u88c2\u89e3\uff0c\u800cMDM2\u539f\u672c\u7684\u4efb\u52a1\u662f\u76d1\u63a7\u5e76\u964d\u89e3\u8fc7\u5269\u7684p53\u3002\u968f\u7740MDM2\u7684\u5931\u6d3b\uff0cp53\u7684\u5bff\u547d\u5f97\u4ee5\u5ef6\u957f\uff0c\u8fdb\u800c\u52a0\u5267\u4e86\u7ec6\u80de\u8870\u8001\u7684\u8fdb\u7a0b\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u53d1\u73b0\uff0c\u751f\u916e\u996e\u98df\u6fc0\u6d3b\u4e86AMPK\uff08\u4e00\u79cd\u8c03\u8282\u80fd\u91cf\u5e73\u8861\u7684\u9176\uff09\uff0c\u4fc3\u8fdb\u4e86p53\u7684\u78f7\u9178\u5316\uff0c\u589e\u5f3a\u4e86p53\u7684\u6d3b\u6027\u3002\u4f7f\u7528AMPK\u6291\u5236\u5242\u80fd\u591f\u963b\u65ad\u8fd9\u4e00\u8fde\u9501\u53cd\u5e94\uff0c\u907f\u514dp53\u7684\u8fc7\u5ea6\u6fc0\u6d3b\u53ca\u5176\u4e0b\u6e38\u6548\u5e94\u5b50p21\u548cSA-\u03b2-gal\u7684\u8868\u8fbe\u3002\u603b\u800c\u8a00\u4e4b\uff0c\u751f\u916e\u996e\u98df\u901a\u8fc7\u6fc0\u6d3bcaspase-2\u9176\uff0c\u5bfc\u81f4MDM2\u86cb\u767d\u5931\u6d3b\uff0c\u4ee5\u53caAMPK\u7684\u6fc0\u6d3b\uff0c\u8fd9\u4e24\u8005\u5747\u5bfc\u81f4p53\u7684\u79ef\u7d2f\uff0c\u8bf1\u5bfc\u7ec6\u80de\u8870\u8001\u3002<\/p>\n<\/p>\n

\u56fe4. \u751f\u916e\u996e\u98df\u6fc0\u6d3bp53\u5e76\u8bf1\u5bfcp21<\/p>\n

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\u53c2\u8003\u6587\u732e\uff1a<\/p>\n

1. Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT.<\/p>\n

DOI:https:\/\/\/10.1016\/j.xcrm.2024.101667<\/p>\n

2. Ketogenic diet induces p53-dependent cellular senescence in multiple organs<\/p>\n

DOI: 10.1126\/sciadv.ado146<\/p>\n<\/tbody>\n

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