{"id":49775,"date":"2025-04-05T05:10:50","date_gmt":"2025-04-05T05:10:50","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=49775"},"modified":"2025-04-05T05:10:50","modified_gmt":"2025-04-05T05:10:50","slug":"2023%e5%b9%b4%e5%9b%bd%e9%99%85%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e5%a4%a7%e4%bc%9aaaic%e5%89%8d%e6%b2%bf%e6%8a%a5%e5%91%8a","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=49775","title":{"rendered":"2023\u5e74\u56fd\u9645\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5927\u4f1a(AAIC)\u524d\u6cbf\u62a5\u544a"},"content":{"rendered":"<h3><b>1 AD\u6cbb\u7597\u8fdb\u5c55\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c<\/b><\/h3>\n<h4><b>1.1 AD\u65b0\u836f\u8fdb\u5c55<\/b><\/h4>\n<p>\t\t\t\t\t\t\t\t\u672c\u6b21\u4f1a\u8bae\u4e0a\uff0c\u793c\u6765\u516c\u53f8\uff08Eli Lilly\uff09\u62a5\u544a\u4e86AD\u65b0\u836fDonanemab\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c<sup>[1]<\/sup>\uff0c\u8fd9\u662f\u4e00\u79cd\u9776\u5411\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\uff08amyloid-\u03b2\uff0cA\u03b2\uff09\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u7528\u4e8e\u6e05\u9664AD\u60a3\u8005\u5927\u8111\u4e2d\u7684A\u03b2\u6c89\u6dc0\uff0c\u4ee5\u671f\u8fbe\u5230AD\u7684\u6cbb\u7597\u6216\u5ef6\u7f13\u7684\u6548\u679c\u3002<\/p>\n<p>\t\t\t\t\t\t\t\t\u5728\u5176\u591a\u4e2d\u5fc3\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8cTRAILBLAZER-ALZ 2\u4e2d\uff0c\u4e00\u51711736\u540d\u7b26\u5408\u6807\u51c6\u7684\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\uff08Mild mild cognitive impairment\uff0cMCI\uff09\u60a3\u8005\u88ab\u6309\u71671:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u5230\u5e72\u9884\u7ec4\uff08\u9759\u8109\u6ce8\u5c04Donanemab\uff09\u548c\u5bf9\u7167\u7ec4\uff08\u9759\u8109\u6ce8\u5c04\u5b89\u6170\u5242\uff09\u3002\u5728\u8fdb\u884c\u5e72\u9884\u524d\uff0c\u53d7\u8bd5\u8005\u63a5\u53d7\u4e86<sup>18<\/sup>F-flortaucipir PET\u626b\u63cf\u4ee5\u8bc4\u4f30tau\u86cb\u767d\u75c5\u7406\u6c34\u5e73\uff0c\u636e\u6b64\u88ab\u5206\u4e3a\u4f4e\/\u4e2dtau\u7ec4\u548c\u9ad8tau\u7ec4\uff08\u66f4\u9ad8\u610f\u5473\u7740\u5904\u4e8e\u66f4\u665a\u671f\u7684AD\u75be\u75c5\u72b6\u6001\uff09\u3002\u5176\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f76\u5468\u540e\u53d7\u8bd5\u8005\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7efc\u5408\u8bc4\u5b9a\u91cf\u8868\u5206\u6570\uff08Integrated Alzheimer&#8217;s Disease Rating Scale\uff0ciADR\uff0c\u8d8a\u4f4e\u4ee3\u8868AD\u75c7\u72b6\u8d8a\u91cd\uff09\u53d8\u5316\u3002\u800c\u6b21\u8981\u7ec8\u70b9\u9664\u4e86\u5305\u62ec\u4f20\u7edf\u7684\u8ba4\u77e5\u8bc4\u4f30\u91cf\u8868\u8bf8\u5982\u7b80\u6613\u7cbe\u795e\u72b6\u6001\u68c0\u67e5\uff08Mini-Mental State Examination\uff0cMMSE\uff09\u5916\uff0c\u8fd8\u6db5\u76d6\u4e86\u591a\u4e2a\u4e0e\u8111\u5185\u86cb\u767d\u8d28\u6c89\u79ef\u548c\u8111\u5bb9\u91cf\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u89c1\u88681\u3002<\/p>\n<h6>\u88681 \u4e3b\u8981\u4e0e\u6b21\u8981\u7ec8\u70b9\u6307\u6807<\/h6>\n<p>Tab 1. Primary and secondary endpoints<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1 AD\u6cbb\u7597\u8fdb\u5c55\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c 1.1 AD\u65b0\u836f\u8fdb\u5c55 \u672c\u6b21\u4f1a\u8bae\u4e0a\uff0c\u793c\u6765\u516c\u53f8\uff08El &hellip; <a href=\"http:\/\/zydq.1006ss.com\/?p=49775\">\u7ee7\u7eed\u9605\u8bfb <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-49775","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/49775","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=49775"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/49775\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=49775"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=49775"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=49775"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}