{"id":49369,"date":"2025-03-27T05:10:58","date_gmt":"2025-03-27T05:10:58","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=49369"},"modified":"2025-03-27T05:10:58","modified_gmt":"2025-03-27T05:10:58","slug":"%e5%bc%a5%e6%bc%ab%e5%a4%a7b%e7%bb%86%e8%83%9e%e6%b7%8b%e5%b7%b4%e7%98%a4%ef%bc%8c%e9%9d%9e%e7%89%b9%e6%ae%8a%e7%b1%bb%e5%9e%8b","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=49369","title":{"rendered":"\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u975e\u7279\u6b8a\u7c7b\u578b"},"content":{"rendered":"<p>\u5b9a\u4e49\uff1a\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u662f\u4e00\u79cd\u4e2d\u7b49\u6216\u5927B\u6dcb\u5df4\u6837\u7ec6\u80de\u6784\u6210\u7684\u80bf\u7624\uff0c\u5176\u7ec6\u80de\u6838\u4e0e\u6b63\u5e38\u5de8\u566c\u7ec6\u80de\u76f8\u540c\u6216\u66f4\u5927\uff0c\u6216\u8005\u662f\u6b63\u5e38\u6dcb\u5df4\u7ec6\u80de\u6838\u7684\u4e24\u500d\u4ee5\u4e0a\uff0c\u5448\u5f25\u6f2b\u6027\u751f\u957f\u6a21\u5f0f\u3002<\/p>\n<p>ICDO\u7f16\u7801\uff1a9680\/3<\/p>\n<p>\u4e34\u5e8a\uff1a\u8001\u5e74\u4eba<\/p>\n<p>\u7ec4\u7ec7\u75c5\u7406\uff1a\u5927\u6dcb\u5df4\u7ec6\u80de\u5f25\u6f2b\u589e\u751f\uff0c\u6dcb\u5df4\u7ed3\u7ed3\u6784\u5b8c\u5168\u6216\u90e8\u5206\u7834\u574f\uff0c\u90e8\u5206\u7d2f\u53ca\u6ee4\u6ce1\u95f4\u533a\uff0c\u8f83\u5c11\u7d2f\u53ca\u6dcb\u5df4\u7aa6\u3002\u5206\u4e3a\u666e\u901a\u7684\u548c\u7f55\u89c1\u7684\u5f62\u6001\u5b66\u53d8\u5f02\u578b\u3002<\/p>\n<p>\u666e\u901a\uff08\u4e2d\u5fc3\u6bcd\u7ec6\u80de\u53d8\u5f02\u578b\uff0c\u4e2d\u7b49\u81f3\u5927\u7684\u6dcb\u5df4\u7ec6\u80de\uff0c\u6838\u5706\u5f62\uff0c\u692d\u5706\u5f62\uff0c\u7a7a\u6ce1\u6837\uff0c\u67d3\u8272\u8d28\u7ec6\uff0c2-4\u4e2a\u6838\u4ec1\uff0c\u80de\u6d46\u8f83\u5c11\uff0c\u55dc\u53cc\u8272\u6216\u55dc\u78b1\u6027\uff0c\u53ef\u7531\u5355\u4e00\u7684\u4e2d\u5fc3\u6bcd\u7ec6\u80de\u6784\u6210\uff0c\u6216\u4e2d\u5fc3\u6bcd\u7ec6\u80de\u6838\u514d\u75ab\u6bcd\u7ec6\u80de\u6df7\u5408\u800c\u6210\uff1b\u514d\u75ab\u6bcd\u7ec6\u80de\u53d8\u5f02\u578b\uff0c90%\u4ee5\u4e0a\u4e3a\u514d\u75ab\u6bcd\u7ec6\u80de\uff0c\u6838\u4ec1\u5c45\u4e2d\uff0c\u80de\u6d46\u4e30\u5bcc\uff0c\u55dc\u78b1\u6027\uff0c\u6709\u65f6\u53ef\u89c1\u6d46\u6837\u5206\u5316\uff1b\u95f4\u53d8\u578b\uff0c\u7ec6\u80de\u4e2d\u504f\u5927\uff0c\u5706\u5f62\uff0c\u692d\u5706\u5f62\uff0c\u591a\u89d2\u5f62\uff0c\u6838\u5f62\u5947\u5f02\uff0c\u4e0d\u89c4\u5219\uff0c\u90e8\u5206\u53ef\u76f8\u4f3c\u4e0e\u970d\u5947\u91d1\u6216R-S\u7ec6\u80de\uff0c\u5e76\u53ef\u76f8\u4f3c\u4e8e\u95f4\u53d8\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\uff09<\/p>\n<p>\u7f55\u89c1\uff08\u7c98\u6db2\u6837\u57fa\u8d28\uff0c\u7ea4\u7ef4\u57fa\u8d28\uff0c\u5047\u83ca\u5f62\u56e2\uff0c\u68ad\u5f62\uff0c\u5370\u6212\u7ec6\u80de\u7279\u5f81\u7b49\uff09<\/p>\n<p>\u514d\u75ab\u7ec4\u5316\uff1a\u5e7f\u6cdb\u8868\u8fbeB\u7ec6\u80de\u6297\u539f\uff08CD19,CD20,CD22,CD79a\uff0cPAX-5\uff0c\u4e5f\u53ef\u4e22\u5931\u5176\u4e2d\u4e00\u79cd\u6216\u591a\u79cd\u6297\u539f\uff09\uff1b\u53ef\u8868\u8fbeCD30(\u5c24\u5176\u95f4\u53d8\u578b)\uff0c10%\u53ef\u8868\u8fbeCD5\uff0c\u4e0d\u8868\u8fbeCyclinD1\u548csox11\uff0c\u9274\u522b\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\uff08\u5c11\u89c1\u60c5\u51b5\u4e0bDLBCL\u53efcyclinD-1\u9633\u6027\uff0c\u4f46sox11\u9634\u6027\uff09\u3002CD138\u5f88\u5c11\u4e0eCD20\u5171\u8868\u8fbe\u3002EBV \u9633\u6027\u5e94\u8bca\u65ad\u4e3a EBV \u9633\u6027 DLBCL\uff0cNOS\uff1b<\/p>\n<p>BCL2(\u226550%\u7684\u80bf\u7624\u7ec6\u80de\u5448\u9633\u6027,\u5219\u5224\u5b9a\u9633\u6027)\uff1b\u5982\u679c\u226540%\u7684\u80bf\u7624\u7ec6\u80de\u6838\u5448\u9633\u6027\uff0c\u5219\u8ba4\u4e3aMYC\u5448\u9633\u6027\u3002\u5982\u679c \u2265 30% \u7684\u80bf\u7624\u7ec6\u80de\u67d3\u8272\u5448\u9633\u6027\uff0c\u5219 CD10\u3001BCL6 \u548c IRF4\/MUM1 \u5747\u88ab\u89c6\u4e3a\u9633\u6027\uff08CD10\u3001BCL6 \u548c MUM1\u53ea\u8981CD10\u9633\u6027\u6216\u53ea\u6709BCL6\u9633\u6027\uff0c\u63d0\u793a\u751f\u53d1\u4e2d\u5fc3\u6765\u6e90\uff09\u3002c-MYC\uff08\u63d0\u793aMYC\u6613\u4f4d\uff09<\/p>\n<p>MYC\u548cBCL2\u53cc\u8868\u8fbe\u4e14\u8fd9\u4e9b\u57fa\u56e0\u6216MYC\u548cBCL6\u91cd\u6392\u7684\u75c5\u4f8b\u5c5e\u4e8e\u5177\u6709MYC\u548cBCL2\u548c\/\u6216BCL6\u91cd\u6392\u7684\u9ad8\u7ea7\u522bB\u7ec6\u80de\u6dcb\u5df4\u7624\u3002<\/p>\n<p>Ki-67\u589e\u6b96\u6307\u6570\u9ad8\uff1b\u901a\u5e38\u9ad8\u4e8e 40%\u3002<\/p>\n<p>\u5206\u5b50\uff1aGCB\uff08germinal centre B-Cell\uff09\u4e9a\u578b\u548cABC\uff08activated B-cell\uff09\u4e9a\u578b\uff1b\u6240\u8c13\u53cc\u6253\u51fb\uff08MYC\u6613\u4f4d\u548c\uff08BCL2 OR BCL6\u91cd\u6392\uff09\uff09\uff1b<\/p>\n<p>\u6709\u56fe\u4e3a\u8bc1\uff1a<\/p>\n<\/p>\n<p>\u56fe5.<\/p>\n<\/p>\n<p>\u56fe6.<\/p>\n<\/p>\n<p>\u56fe7.<\/p>\n<\/p>\n<p>\u56fe8.<\/p>\n<\/p>\n<p>\u56fe9.\u80bf\u7624\u5f25\u6f2b\u751f\u957f\uff0c\u6d78\u6da6\u5c0f\u8840\u7ba1<\/p>\n<\/p>\n<p>\u56fe14<\/p>\n<\/p>\n<p>\u56fe1.A,\u5178\u578b\u7684\u4e2d\u5fc3\u6bcd\u7ec6\u80de\u578b\uff0c\u591a\u4e2a\u6838\u4ec1\uff0cB.\u7ec6\u80de\u591a\u5f62\u6027\uff0c\u591a\u53f6\u6838<\/p>\n<\/p>\n<p>\u56fe10\uff0c\u4e2d\u5fc3\u6bcd\u7ec6\u80de\u578b<\/p>\n<\/p>\n<p>\u56fe2.\u514d\u75ab\u6bcd\u7ec6\u80de\u4e9a\u578b\uff0c\u5c45\u4e2d\u7a81\u51fa\u7684\u6838\u4ec1\u3002<\/p>\n<\/p>\n<p>\u56fe15<\/p>\n<\/p>\n<p>\u56fe11.\u514d\u75ab\u6bcd\u7ec6\u80de\u578b<\/p>\n<\/p>\n<p>\u56fe12\uff0c\u95f4\u53d8\u578b<\/p>\n<\/p>\n<p>\u56fe3.\u95f4\u53d8\u578b<\/p>\n<\/p>\n<p>\u56fe16<\/p>\n<\/p>\n<p>\u56fe17<\/p>\n<\/p>\n<p>\u56fe18<\/p>\n<\/p>\n<p>\u56fe20\uff0c\u68ad\u5f62\u7ec6\u80de\u5f62\u6001\uff0ca\uff1a\u80bf\u7624\u6027\u68ad\u5f62\u7ec6\u80de\u6392\u5217\u6210\u77ed\u675f\uff0c\u4ea7\u751f\u6a21\u7cca\u7684\u5e2d\u7eb9\u72b6\u56fe\u6848\u3002(b)\u80bf\u7624\u6027\u68ad\u5f62\u7ec6\u80de\u542b\u6709\u692d\u5706\u5f62\u3001\u62c9\u957f\u6216\u6298\u53e0\u7684\u6ce1\u72b6\u6838\u548c\u4e00\u5230\u51e0\u4e2a\u5c0f\u6838\u4ec1\u3002\u7ec6\u80de\u8d28\u6570\u91cf\u9002\u4e2d\uff0c\u7ec6\u80de\u8fb9\u754c\u6e05\u6670\u3002(c) \u6dcb\u5df4\u7624\u7ec6\u80de\u5448\u73b0\u7ec6\u957f\u7ed3\u6784\u5e76\u5177\u6709\u7ec6\u957f\u7684\u7ec6\u80de\u6838\u3002(d) \u75c5\u4f8b 4 \u4e2d\u7684\u80bf\u7624\u6027\u68ad\u5f62\u7ec6\u80de\u8868\u73b0\u51fa\u4e0e\u6297 CD20 \u7684\u5f3a\u70c8\u514d\u75ab\u53cd\u5e94\u6027\uff0c\u8bc1\u5b9e\u4e86 B \u7ec6\u80de\u8c31\u7cfb\u3002<\/p>\n<\/p>\n<p>\u56fe21\uff0c\u68ad\u5f62\u7ec6\u80de\u578b<\/p>\n<\/p>\n<p>\u56fe22\uff0c\u68ad\u5f62\u7ec6\u80de\u578bA.CD45,B.CD20,C.BCL6<\/p>\n<\/p>\n<p>\u56fe23<\/p>\n<\/p>\n<p>\u56fe24\u300223,24\u5747\u4e3a\u68ad\u5f62\u7ec6\u80de\u578b\uff0cCD45,CD20\u9633\u6027<\/p>\n<\/p>\n<p>\u56fe4.\u514d\u75ab\u7ec4\u5316\uff0cBCL2 AND&nbsp;MYC<\/p>\n<\/p>\n<p>\u56fe13\uff0cMYC(L),BCL2(R)<\/p>\n<\/p>\n<p>\u56fe19\uff0cCD30\u9633\u6027<\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<li>\n<p>WHO Classification of Tumours of&nbsp;Haematopoietic and Lymphoid Tissues\uff084th\uff09\uff08\u56fe1-5\uff09<\/p>\n<\/li>\n<li>\n<p>\u5218\u5f64\u534e\u8bca\u65ad\u75c5\u7406\u5b66\uff084th\uff09\uff08\u56fe9-13\uff09<\/p>\n<\/li>\n<li>\n<p>\u7f57\u585e\u548c\u963f\u514b\u66fc\u5916\u79d1\u75c5\u7406\u5b66\uff0811th\uff09\uff08\u56fe14-18\uff09<\/p>\n<\/li>\n<p>4.Slack GW, Steidl C, Sehn LH, Gascoyne RD. CD30 expression in de novo diffuse&nbsp;large B-cell lymphoma: a population-based study from British Columbia. Br J&nbsp;Haematol. 2014 Dec;167(5):608-17. doi: 10.1111\/bjh.13085. Epub 2014 Aug 19.\uff08\u56fe19\uff09<\/p>\n<p>5.Carbone A, etal. A spindle cell variant of diffuse large B-cell lymphoma possesses genotypic&nbsp;and phenotypic markers characteristic of a germinal center B-cell origin. Mod&nbsp;Pathol. 2006 Feb;19(2):299-306. doi: 10.1038\/modpathol.3800540.\uff08\u56fe20\uff09<\/p>\n<p>6.Chi AC, Coles RL, Ledford CL, Neville BW, Lazarchick J. Spindle cell lymphoma&nbsp;of the oral cavity: a case report and review of the literature. J Oral&nbsp;Maxillofac Surg. 2012 Sep;70(9):2229-37. doi: 10.1016\/j.joms.2011.09.026.&nbsp;\uff08\u56fe21\uff0c22\uff09<\/p>\n<p>7: Murata H,etal.Two cases of spindle cell variant diffuse large B-cell lymphoma of the uterine&nbsp;cervix. Gynecol Oncol Rep. 2020 Jul 15;33:100611. doi:10.1016\/j.gore.2020.100611.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5b9a\u4e49\uff1a\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u662f\u4e00\u79cd\u4e2d\u7b49\u6216\u5927B\u6dcb\u5df4\u6837\u7ec6\u80de\u6784\u6210\u7684\u80bf\u7624\uff0c\u5176 &hellip; <a href=\"http:\/\/zydq.1006ss.com\/?p=49369\">\u7ee7\u7eed\u9605\u8bfb <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-49369","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/49369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=49369"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/49369\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=49369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=49369"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=49369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}