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1.\u7834\u683c\u6551\u5fc3\u6c64\u7684\u7ec4\u65b9\u4e0e\u529f\u6548<\/p>\n
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\u7834\u683c\u6551\u5fc3\u6c64\u4e3b\u6cbb\u9634\u9633\u4ff1\u8131\u8bc1\u3002<\/p>\n
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2.\u9644\u5b50\u7684\u5f3a\u5fc3\u4f5c\u7528\u4e0e\u6bd2\u6027<\/p>\n
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3.\u7834\u683c\u6551\u5fc3\u6c64\u7684\u5242\u91cf<\/p>\n
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1.\u714e\u716e<\/p>\n
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2.\u914d\u4f0d<\/p>\n
\u7518\u8349\u53ef\u4ee5\u89e3\u9644\u5b50\u4e4b\u6bd2\u3002<\/p>\n
\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u6b21\u4e4c\u5934\u78b1\u4e0e\u7518\u8349\u82f7\u3001\u7518\u8349\u6b21\u9178\u914d\u4f0d\u901a\u8fc7\u964d\u4f4e\u6b21\u4e4c\u5934\u78b1\u5bf9\u5fc3\u808c\u7ec6\u80de\u7684\u6c27\u5316\u635f\u4f24\u6765\u51cf\u8f7b\u5176\u6bd2\u6027\u4f5c\u7528\uff0c\u589e\u5f3a\u5176\u6d3b\u529b\u3002<\/p>\n
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\u5e72\u59dc\u6c34\u714e\u6db2\u53ef\u4ee5\u6539\u5584\u5fc3\u808c\u7ec6\u80de\u7ebf\u7c92\u4f53\u529f\u80fd\u635f\u4f24\u3002<\/p>\n
\u9644\u5b50\u5e72\u59dc\u6c34\u714e\u6db2\u53ef\u901a\u8fc7\u8c03\u8282\u80fd\u91cf\u4ee3\u8c22\u6765\u4fdd\u62a4\u7f3a\u6c27\/\u590d\u6c27\u635f\u4f24\u7684H9c2\u5fc3\u808c\u7ec6\u80de\uff0c\u6d53\u5ea6\u4e3a0.25mg\/mL\u65f6\u4fdd\u62a4\u4f5c\u7528\u6700\u5f3a\uff1b<\/p>\n
\u901a\u8fc7PI3K\/Akt\/GSK-3\u03b2\u4fe1\u53f7\u4f20\u5bfc\u548c\u6291\u5236\u7ebf\u7c92\u4f53\u4f9d\u8d56\u6027\u51cb\u4ea1\u9014\u5f84\u6765\u51cf\u8f7b\u7f3a\u8840\/\u518d\u704c\u6ce8\u635f\u4f24\uff0c\u4e14\u7528\u836f\u91cf\u4e3a2.8g\/kg\u65f6\u4fdd\u62a4\u6548\u679c\u6700\u4f73\u3002<\/p>\n
\u5927\u5242\u91cf\u7684\u5c71\u8438\u8089\u53ef\u4ee5\u5f88\u597d\u5730\u5236\u7ea6\u9644\u5b50\u7684\u6bd2\u6027\u4f5c\u7528\u3002<\/p>\n
\u5c71\u8331\u8438\u53ef\u80fd\u901a\u8fc7\u5176\u6240\u542b\u7684\u6c34\u6eb6\u6027\u7684\u6709\u673a\u9178\u3001\u97a3\u8d28\u7c7b\u6210\u5206\u4e0e\u9644\u5b50\u7684\u5355\u916f\u578b\u751f\u7269\u78b1\u53d1\u751f\u7edc\u5408\u53cd\u5e94\uff0c\u4ece\u800c\u6709\u53ef\u80fd\u964d\u4f4e\u9644\u5b50\u6bd2\u526f\u4f5c\u7528\u3002<\/p>\n
\u6b64\u5916\uff0c\u9644\u5b50\u751f\u7269\u78b1\u4e0e\u4eba\u53c2\u603b\u7682\u82f7\u8054\u7528\u540e\uff0c\u751f\u7269\u78b1\u7684\u5438\u6536\u548c\u751f\u7269\u5229\u7528\u5ea6\u5747\u5f97\u5230\u63d0\u9ad8\uff0c\u5e76\u4e14\u505c\u7559\u65f6\u95f4\u5ef6\u957f\uff0c\u5bf9\u6025\u6027\u5fc3\u529b\u8870\u7aed\u5927\u9f20\u7684\u6cbb\u7597\u4f5c\u7528\u589e\u5f3a\u3002<\/p>\n
\u603b\u7684\u6765\u8bf4\uff0c\u6b63\u786e\u7684\u714e\u716e\u548c\u5408\u7406\u7684\u914d\u4f0d\u90fd\u53ef\u4ee5\u4fdd\u8bc1\u7834\u683c\u6551\u5fc3\u6c64\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n
1.\u96be\u6cbb\u6027\u5fc3\u529b\u8870\u7aed<\/p>\n
\u96be\u6cbb\u6027\u5fc3\u529b\u8870\u7aed\uff0c\u53c8\u79f0\u987d\u56fa\u6027\u5fc3\u529b\u8870\u7aed\uff0c\u5c5e\u4e8e\u665a\u671f\u5fc3\u529b\u8870\u7aed\uff0c\u5373\u5728\u4f11\u606f\u65f6\u51fa\u73b0\u4e25\u91cd\u5fc3\u8870\u75c7\u72b6\u548c\/\u6216\u4f53\u5f81\u3002<\/p>\n
\u4e2d\u533b\u5b66\u8ba4\u4e3a\u6162\u6027\u5fc3\u529b\u8870\u7aed\u5c5e\u4e8e\u672c\u865a\u6807\u5b9e\u4e4b\u8bc1\uff0c\u5fc3\u6c14\u4e8f\u865a\u662f\u53d1\u75c5\u4e4b\u672c\uff1b\u96be\u6cbb\u6027\u5fc3\u529b\u8870\u7aed\u7684\u4e2d\u533b\u6838\u5fc3\u8bc1\u5019\u4e3a\u6c14\u865a\u8840\u7600\u8bc1\uff0c\u4e14\u591a\u8868\u73b0\u4e3a\u91cd\u5ea6\u7684\u9633\u865a\u3001\u6c34\u996e\u8bc1\u3002<\/p>\n
\u4e34\u5e8a\u7814\u7a76\u53d1\u73b0\uff0c\u8fd0\u7528\u7834\u683c\u6551\u5fc3\u6c64\u52a0\u51cf\u7ed3\u5408\u897f\u533b\u5e38\u89c4\u6cbb\u7597\u3002<\/p>\n
\u53ef\u663e\u8457\u6539\u5584\u96be\u6cbb\u6027\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u5fc3\u529f\u80fd\u548c\u4e34\u5e8a\u75c7\u72b6\uff0c\u63d0\u9ad8\u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff08LVEF\uff09\u3001\u5fc3\u8f93\u51fa\u91cf\uff08CO\uff09\u53ca\u8840\u6d46\u8111\u94a0\u80bd\uff08BNP\uff09\uff0c\u8fdb\u800c\u6539\u5584\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\uff0c\u63d0\u9ad8\u4e34\u5e8a\u6cbb\u7597\u603b\u6709\u6548\u7387\u3002<\/p>\n
\u52a8\u7269\u7814\u7a76\u53d1\u73b0\uff0c\u7834\u683c\u6551\u5fc3\u6c64\u4f7f\u6162\u6027\u5fc3\u8870\u5927\u9f20\u7684\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\uff08TNF-\u03b1\uff09\u6c34\u5e73\u964d\u4f4e\uff0c\u767d\u7ec6\u80de\u4ecb\u7d20-10\uff08IL-10\uff09\u6c34\u5e73\u8fdb\u4e00\u6b65\u5347\u9ad8\u3002<\/p>\n
\u4ece\u800c\u8c03\u8282\u7ec6\u80de\u56e0\u5b50\u7f51\u7edc\u7cfb\u7edf\uff0c\u8d77\u5230\u6709\u6548\u4fdd\u62a4\u5fc3\u808c\u3001\u6539\u5584\u5fc3\u529f\u80fd\u7684\u4f5c\u7528\u3002<\/p>\n
\u6b64\u5916\uff0c\u7834\u683c\u6551\u5fc3\u6c64\u53ef\u80fd\u901a\u8fc7\u964d\u4f4e\u5927\u9f20\u8840\u6d46\u4e2d\u80be\u7d20-\u8840\u7ba1\u7d27\u5f20\u7d20-\u919b\u56fa\u916e\u7cfb\u7edf\uff08RAAS\uff09\u7684\u6fc0\u5316\u6c34\u5e73\u7279\u522b\u662f\u919b\u56fa\u916e\uff08ALD\uff09\u548c\u8840\u7ba1\u7d27\u5f20\u7d20\u2161\uff08Ang\u2161\uff09\u6c34\u5e73\uff0c\u8fdb\u800c\u6539\u5584\u5fc3\u810f\u540e\u8d1f\u8377\u3002<\/p>\n
\u7834\u683c\u6551\u5fc3\u6c64\u52a0\u51cf\u53ef\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u6539\u5584\u5fc3\u529b\u8870\u7aed\u5927\u9f20\u5fc3\u808c\u80fd\u91cf\u4ee3\u8c22\uff0c\u4fc3\u8fdb\u5fc3\u529f\u80fd\u6062\u590d\uff0c\u5176\u4f5c\u7528\u673a\u5236\u53ef\u80fd\u4e0e\u6fc0\u6d3bSIRT1\/PGC-1\u03b1\u4fe1\u53f7\u901a\u8def\u76f8\u5173\u3002<\/p>\n
2.\u6025\u6027\u5fc3\u529b\u8870\u7aed\uff08AHF\uff09<\/p>\n
AHF\u662f\u6307\u5fc3\u8870\u75c7\u72b6\u548c\u4f53\u5f81\u8fc5\u901f\u53d1\u751f\u6216\u6076\u5316\u7684\u4e00\u79cd\u4e34\u5e8a\u7efc\u5408\u5f81\u3002<\/p>\n
\u4e2d\u533b\u5b66\u8ba4\u4e3aAHF\u5c5e\u4e8e\u201c\u5598\u8131\u201d\u201c\u5fc3\u6c34\u201d\u201c\u6c34\u80bf\u201d\u201c\u4ea1\u9633\u201d\u7b49\u8303\u7574\u3002<\/p>\n
\u75c5\u4f4d\u5728\u5fc3\uff0c\u6d89\u53ca\u809d\u3001\u813e\u3001\u80be\u3002<\/p>\n
\u5c5e\u672c\u865a\u6807\u5b9e\u8bc1\uff0c\u4ee5\u6c14\u865a\u3001\u9633\u865a\u3001\u9634\u865a\u4e3a\u4e3b\uff0c\u517c\u6709\u75f0\u3001\u7600\u3001\u6e7f\u3001\u6ede\u7684\u6807\u5b9e\u3002<\/p>\n
\u6cbb\u7597\u4e0a\uff0c\u9996\u5f53\u6e29\u8865\u5fc3\u80be\uff0c\u517c\u4ee5\u884c\u6c14\u3001\u795b\u75f0\u3001\u5316\u7600\u3001\u5229\u6c34\u3002<\/p>\n
\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u7834\u683c\u6551\u5fc3\u6c64\u8054\u5408\u91cd\u7ec4\u4ebaBNP\u80bd\u53ef\u663e\u8457\u63d0\u9ad8AHF\u7684\u4e34\u5e8a\u7597\u6548\uff0c\u6539\u5584\u5fc3\u80be\u529f\u80fd\uff0c\u964d\u4f4e\u8840\u6e05BNP\u3001\u78f7\u9178\u808c\u9178\u6fc0\u9176\u540c\u5de5\u9176\uff08CK-MB\uff09\u53ca\u808c\u9499\u86cb\u767d\uff08IcTnI\uff09\u6c34\u5e73\u3002<\/p>\n
\u5728\u5e38\u89c4AHF\u6cbb\u7597\u57fa\u7840\u4e0a\u52a0\u7528\u7834\u683c\u6551\u5fc3\u6c64\u8054\u5408\u65e0\u521b\u8f85\u52a9\u901a\u6c14\uff0c\u53ef\u6709\u6548\u6539\u5584\u60a3\u8005\u7684\u5fc3\u529f\u80fd\uff0c\u51cf\u7f13\u75c5\u60c5\uff0c\u63d0\u9ad8\u6551\u6cbb\u7387\uff0c\u4e14\u964d\u4f4e\u4e86\u60a3\u8005\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u7387\u3002<\/p>\n
\u5728\u53e6\u4e00\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u5e38\u89c4\u6cbb\u7597\u57fa\u7840\u4e0a\u52a0\u7528\u7834\u683c\u6551\u5fc3\u6c64\u6bd4\u52a0\u7528\u5de6\u897f\u5b5f\u65e6\u66f4\u597d\u5730\u6539\u5584AHF\u60a3\u8005\u7684\u8840\u6d41\u52a8\u529b\u5b66\u6307\u6807\u3002<\/p>\n
\u56e0\u6b64\uff0c\u5728\u5fc3\u8870\u6025\u6027\u53d1\u4f5c\u65f6\uff0c\u4f9d\u636e\u60a3\u8005\u75c5\u60c5\u52a0\u7528\u7834\u683c\u6551\u5fc3\u6c64\u53ef\u4ee5\u6709\u6548\u6539\u5584AHF\u75c5\u60c5\u3002<\/p>\n
3.\u80ba\u6e90\u6027\u5fc3\u810f\u75c5\uff08\u7b80\u79f0\u80ba\u5fc3\u75c5\uff09<\/p>\n
\u80ba\u5fc3\u75c5\u662f\u6307\u56e0\u80ba\u7ec4\u7ec7\u3001\u80ba\u8840\u7ba1\u3001\u80f8\u5ed3\u7b49\u7ed3\u6784\u548c\uff08\u6216\uff09\u5176\u529f\u80fd\u5f02\u5e38\uff0c\u8fc1\u5ef6\u65e5\u4e45\u4f7f\u80ba\u52a8\u8109\u538b\u529b\u5347\u9ad8\uff0c\u6539\u53d8\u53f3\u5fc3\u5ba4\u7684\u7ed3\u6784\u548c\u529f\u80fd\u3002<\/p>\n
\u4e2d\u533b\u5b66\u8ba4\u4e3a\u80ba\u5fc3\u75c5\u5e94\u5f52\u7c7b\u4e3a\u201c\u5598\u75c5\u201d\u201c\u6c34\u80bf\u201d\u201c\u6c34\u996e\u201d\u7b49\u3002<\/p>\n
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\u4e34\u5e8a\u6cbb\u7597\u53d1\u73b0\uff0c\u52a0\u5473\u7834\u683c\u6551\u5fc3\u6c64\u53ef\u660e\u663e\u6539\u5584\u80ba\u5fc3\u75c5\u9633\u865a\u6c34\u6cdb\u578b\u60a3\u8005\u7684\u5fc3\u80ba\u529f\u80fd\uff0c\u4e34\u5e8a\u7597\u6548\u663e\u8457\u3002<\/p>\n
\u5728\u4e00\u9879\u56de\u987e\u6027\u5206\u6790[40]\u4e2d\u53d1\u73b0\uff0c\u52a0\u5473\u7834\u683c\u6551\u5fc3\u6c64\u8054\u5408N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u53ef\u4ee5\u6539\u5584\u80ba\u5fc3\u75c5\u60a3\u8005\u7684\u5fc3\u529f\u80fd\u53ca\u80ba\u529f\u80fd\uff0c\u964d\u4f4e\u4e2d\u533b\u8bc1\u5019\u79ef\u5206\uff0c\u4e14\u4e0d\u826f\u53cd\u5e94\u8f83\u5c11\u3002<\/p>\n
4.\u5fc3\u6e90\u6027\u4f11\u514b\uff08CS\uff09<\/p>\n
CS\u6307\u5728\u8840\u7ba1\u5185\u5bb9\u91cf\u53ca\u5de6\u5fc3\u5ba4\u5145\u76c8\u538b\u6b63\u5e38\u7684\u60c5\u51b5\u4e0b\uff0c\u7531\u4e8e\u5fc3\u529f\u80fd\u4e0d\u5168\uff0c\u5bfc\u81f4\u7684\u6301\u7eed\u6027\u4f4e\u8840\u538b\u53ca\u7ec4\u7ec7\u704c\u6ce8\u4e0d\u8db3\u3002<\/p>\n
\u4e34\u5e8a\u4e0a\u53d1\u73b0\u52a0\u7528\u7834\u683c\u6551\u5fc3\u6c64\u80fd\u6709\u6548\u51cf\u7f13\u5e94\u7528\u591a\u5df4\u80fa\u65e0\u6548\u7684CS\u7684\u5371\u6025\u75c7\u72b6\uff0c\u66f4\u597d\u5730\u7ef4\u6301\u8840\u538b\u3001\u5fc3\u7387\u6c34\u5e73\u548c\u5e2e\u52a9\u5176\u5b83\u5404\u9879\u751f\u547d\u4f53\u5f81\u7684\u597d\u8f6c\u3002<\/p>\n
\u4e00\u9879\u4e34\u5e8a\u7814\u7a76\u6307\u51fa\uff0c\u52a0\u7528\u7834\u683c\u6551\u5fc3\u6c64\u53ef\u4ee5\u663e\u8457\u6539\u5584\u6025\u6027\u5fc3\u808c\u6897\u6b7b\u4f34\u5fc3\u6e90\u6027\u4f11\u514b\u60a3\u8005\u7684\u4e34\u5e8a\u75c7\u72b6\u3002<\/p>\n
\u6539\u5584\u60a3\u8005\u7684\u5fc3\u808c\u9176\u6307\u6807\u6c34\u5e73\u548c\u5fc3\u529f\u80fd\uff0c\u964d\u4f4e\u8840\u6e05\u8111\u94a0\u80bd\uff08BNP\uff09\u3001\u4e00\u6c27\u5316\u75f0\u5408\u9176\uff08NOS\uff09\u6c34\u5e73\u3002<\/p>\n
5.\u5fc3\u810f\u9aa4\u505c<\/p>\n
\u7834\u683c\u6551\u5fc3\u6c64\u53ef\u633d\u5782\u7edd\u4e4b\u9633\uff0c\u6551\u66b4\u8131\u4e4b\u9634\uff08\u5305\u62ec\u4e00\u5207\u5faa\u73af\u8870\u7aed\uff09\u3002<\/p>\n
\u5728\u4e34\u5e8a\u4e0a\u53d1\u73b0\u7834\u683c\u6551\u5fc3\u6c64\u7ed3\u5408\u73b0\u4ee3\u533b\u5b66\u6280\u672f\u6551\u6cbb\u5fc3\u810f\u9aa4\u505c\u60a3\u8005\u3002<\/p>\n
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