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\u88681. \u7ee7\u53d1\u6027\u673a\u5316\u6027\u80ba\u708e\u7684\u75c5\u56e0*<\/p>\n
* \u7ee7\u53d1\u6027\u75c5\u56e0\u7684\u4fe1\u606f\u6765\u81eaCottin\u548cCordier 5\u3001Lohr\u7b496\u3001Boots\u7b497\u3001Chang\u7b498\u3001Barroso\u7b499\u3001Sveinsson\u7b4910\u3001Drakopanagiotakis\u7b4911\u548cWang\u7b4912\u7684\u8f6e\u5e73\u7a33\u3002HHV-7\u8868\u793a\u4eba\u75b1\u75b9\u75c5\u6bd27\uff0cHIV\u8868\u793a\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff0cRSV\u8868\u793a\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\uff0cSARS-CoV-2\u8868\u793a\u4e25\u91cd\u6025\u6027\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd22\u3002<\/p>\n
\u6d41\u884c\u75c5\u5b66<\/p>\n
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\u80ba\u6ce1\u673a\u5316<\/p>\n
\u6210\u7ea4\u7ef4\u7ec6\u80de\u88ab\u52df\u96c6\u5230\u80ba\u6ce1\u8154\uff0c\u5728\u80ba\u6ce1\u8154\u589e\u6b96\uff0c\u5206\u5316\u6210\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u5e76\u5f62\u6210\u7ea4\u7ef4\u708e\u6027\u82bd\uff08Masson\u5c0f\u4f53\uff09\uff0c\u8fd9\u662f\u673a\u5316\u6027\u80ba\u708e\u7684\u7279\u5f8152\uff08\u56fe1B\uff09\u3002\u7ea4\u7ef4\u708e\u6027\u82bd\u4e0e\u758f\u677e\u7684\u7ed3\u7f14\u7ec4\u7ec7\u57fa\u8d28\u4ea4\u9519\uff0c\u57fa\u8d28\u5185\u5bcc\u542b\u80f6\u539f\u86cb\u767d\uff08\u5c24\u5176\u662f\u80f6\u539f\u2160\uff09\u3001\u7ea4\u8fde\u86cb\u767d\u3001\u2162\u578b\u524d\u80f6\u539f\u86cb\u767d\u3001\u751f\u8171\u86cb\u767dC\u548c\u86cb\u767d\u805a\u7cd653,54\u3002\u86cb\u767d\u8c03\u8282\u5f02\u5e38\uff08\u6d89\u53ca\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u3001\u78b1\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u548c\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176[MMP]\uff09\u53d1\u751f\uff1b\u5728\u673a\u5316\u6027\u80ba\u708e\u4e2d\uff0c\u86cb\u767d\u8d28\u8c03\u8282\u5f02\u5e38\u4e0e\u65b0\u5f62\u6210\u7684\u8154\u5185\u7ea4\u7ef4\u9ecf\u6db2\u7ed3\u7f14\u7ec4\u7ec7\u7684\u8840\u7ba1\u751f\u6210\u6d3b\u6027\u76f8\u517357\u3002<\/p>\n
\u91cd\u6784<\/p>\n
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Masson\u5c0f\u4f53\u4e0e\u6210\u7ea4\u7ef4\u7ec6\u80de\u7076\u7684\u6bd4\u8f83<\/p>\n
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\u7b2c\u56db\uff0c\u867d\u7136\u673a\u5316\u6027\u80ba\u708e\u4e2d\u7684Masson\u5c0f\u4f53\u4e0eUIP\u4e2d\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u7076\u6709\u4e00\u4e9b\u5171\u540c\u7684\u5f62\u6001\u5b66\u7279\u5f81\uff0c\u4f46\u8fd9\u4e24\u79cd\u75c5\u7a0b\u7684\u7ed3\u5c40\u660e\u663e\u4e0d\u540c51\u3002\u5728UIP\u4e2d\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7076\u4f3c\u4e4e\u9a71\u52a8\u4e86\u4e0d\u53ef\u9006\u7684\u7ea4\u7ef4\u5316\u8fc7\u7a0b\uff0c\u800c\u673a\u5316\u6027\u80ba\u708e\u4e2d\u7684\u7ea4\u7ef4\u9ecf\u6db2\u6837\u75c5\u53d8\u662f\u53ef\u9006\u7684\u3002\u5728\u673a\u5316\u6027\u80ba\u708e\u7684\u7ea4\u7ef4\u9ecf\u6db2\u6837\u75c5\u53d8\u548cUIP\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u7076\u4e2d\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\u589e\u6b96\u7387\u662f\u76f8\u4f3c\u7684\u3002\u7136\u800c\uff0c\u4e0eUIP\u76f8\u6bd4\uff0c\u5728\u673a\u5316\u6027\u80ba\u708e\u7684\u80ba\u6ce1\u5185\u82bd\u4e2d\uff0c\u51cb\u4ea1\u6d3b\u6027\u8f83\u9ad866\u3002<\/p>\n
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\u6700\u540e\uff0c\u5728UIP\u4e2d\uff0c\u7531\u4e8e\u7ed3\u7f14\u7ec4\u7ec7\u7684\u6301\u7eed\u6c89\u79ef\u548c\u80ba\u6ce1\u584c\u9677\uff0c\u80ba\u5b9e\u8d28\u6536\u7f29\u5e76\u673a\u68b0\u53d8\u5f6269\u3002\u4e0a\u8ff0\u6c89\u79ef\u548c\u80ba\u6ce1\u584c\u9677\u4fc3\u53d1\u4e86\u5728\u8be5\u75be\u75c5\u4e2d\u89c2\u5bdf\u5230\u7684\u6c38\u4e45\u6027\u7ec4\u7ec7\u91cd\u678451,70\u3002<\/p>\n
\u4e34\u5e8a\u8868\u73b0<\/p>\n
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\u636e\u62a5\u9053\uff0c10%\uff5e15%\u7684\u75c5\u4f8b\u51fa\u73b0\u6d41\u611f\u6837\u75c7\u72b6\uff08\u5373\u9f3b\u585e\u3001\u5934\u75db\u3001\u5bd2\u6218\u548c\u51fa\u6c57\u3001\u54bd\u75db\u3001\u54b3\u55fd\u3001\u75b2\u52b3\u3001\u808c\u75db\u548c\u53d1\u70ed\uff09\u300244%\u7684COP\u75c5\u4f8b\u6709\u53d1\u70ed\u3002\u54af\u8840\u7684\u53d1\u751f\u7387\u5f88\u4f4e\uff08\uff1c5%\uff09\u3002<\/p>\n
\u4f53\u683c\u68c0\u67e5\u4e2d\u6700\u5e38\u89c1\u7684\u53d1\u73b0\u662f\u5438\u6c14\u6027\u7206\u88c2\u97f3\uff0860%\u7684\u62a5\u544a\u75c5\u4f8b\uff091,6-11,19,20,26,29,33,34,44,45\u3002\u6775\u72b6\u6307\u5f88\u5c11\u89c1\uff08\uff1c3%\u7684\u75c5\u4f8b\u62a5\u544a\uff09\u3002\u5728\u4e0d\u52305%\u7684COP\u60a3\u8005\u4e2d\uff0c\u4f53\u683c\u68c0\u67e5\u6b63\u5e38\u3002<\/p>\n
\u8bca\u65ad\u6027\u8bc4\u4f30<\/p>\n
\u6211\u4eec\u9700\u8981\u91c7\u7528\u591a\u5b66\u79d1\u65b9\u6cd5\uff0c\u7ed3\u5408\u4e34\u5e8a\u3001\u5f71\u50cf\u5b66\u548c\u75c5\u7406\u5b66\u4e13\u4e1a\u77e5\u8bc6\u6765\u8bca\u65adCOP2,3\u3002<\/p>\n
\u5b9e\u9a8c\u5ba4\u68c0\u67e5<\/p>\n
COP\u60a3\u8005\u7684\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7ed3\u679c\u4e0d\u5177\u6709\u7279\u5f02\u6027\u3002\u7136\u800c\uff0c\u708e\u75c7\u6807\u5fd7\u7269\uff08\u5982\u7ea2\u7ec6\u80de\u6c89\u964d\u7387\u3001C\u53cd\u5e94\u86cb\u767d\u6c34\u5e73\u548c\u767d\u7ec6\u80de\u8ba1\u6570\uff09\u5e38\u5347\u9ad86,7,9-11,21,23,27,30,33,34,37\u3002\u673a\u5316\u6027\u80ba\u708e\u60a3\u8005\u53ef\u80fd\u5728\u51fa\u73b0\u76f8\u5173\u7ed3\u7f14\u7ec4\u7ec7\u75c5\u524d\u6570\u5468\u81f3\u6570\u6708\u5c31\u8bca44\u3002\u56e0\u6b64\uff0c\u5982\u679c\u6000\u7591\u7ed3\u7f14\u7ec4\u7ec7\u75c5\uff0c\u5e94\u9488\u5bf9\u8fd9\u4e9b\u75be\u75c5\u8fdb\u884c\u68c0\u6d4b\uff08\u5982\u6297\u6838\u6297\u4f53\u3001\u7c7b\u98ce\u6e7f\u56e0\u5b50\u3001\u6297\u73af\u74dc\u6c28\u9178\u80bd\u3001\u808c\u9178\u6fc0\u9176\u3001\u6297\u62d3\u6251\u5f02\u6784\u9176[\u6297Scl-70]\u6297\u4f53\u3001\u6297\u7740\u4e1d\u7c92\u6297\u4f53\u3001\u6297\u53cc\u94feDNA\u6297\u4f53\uff0c\u4ee5\u53ca\u6297Jo-1\u6297\u4f53\u548c\u5176\u4ed6\u6297\u5408\u6210\u9176\u6297\u4f53\uff0944\u3002<\/p>\n
\u80ba\u529f\u80fd\u68c0\u67e5<\/p>\n
\u80ba\u529f\u80fd\u68c0\u67e5\u7ed3\u679c\u5e38\u663e\u793a\u9650\u5236\u6027\u901a\u6c14\u969c\u788d\u548c\u4e00\u6c27\u5316\u78b3\u5f25\u6563\u91cf\u964d\u4f4e1,6,8,9,14,21,26,29,34,36,47\u3002\u5728\u591a\u8fbe25%\u7684COP\u60a3\u8005\u4e2d\uff0c\u80ba\u5bb9\u91cf\u6b63\u5e3811\u3002\u9664\u65e2\u5f80\u6216\u5f53\u524d\u5438\u70df\u7684\u60a3\u8005\u5916\uff0c\u6c14\u6d41\u963b\u585e\u4e0d\u662fCOP\u7684\u8868\u73b06,7,24,71\u3002\u75be\u75c5\u786e\u8bca\u65f6\uff0c\u80ba\u90e8\u50f5\u786c\u3001\u65e0\u987a\u5e94\u6027\uff0c\u5728\u6cbb\u7597\u6709\u6548\u7684\u60a3\u8005\u4e2d\uff0c\u80ba\u90e8\u53ef\u6062\u590d\u6b63\u5e3871\u3002\u4f11\u606f\u548c\u8fd0\u52a8\u671f\u95f4\u51fa\u73b0\u52a8\u8109\u4f4e\u6c27\u8840\u75c7\u7684\u60c5\u51b5\u5e38\u89c18,9,11,14,21,23\u3002<\/p>\n
\u5f71\u50cf\u5b66\u68c0\u67e5<\/p>\n
COP\u7684\u5f71\u50cf\u5b66\u8868\u73b0\u591a\u79cd\u591a\u6837\u3002COP\u60a3\u8005\u7684\u80f8\u7247\u901a\u5e38\u6709\u7279\u5f81\u6027\u8868\u73b0\uff0c\u5728\u80ba\u5bb9\u91cf\u6b63\u5e38\u7684\u60c5\u51b5\u4e0b\uff0c\u8868\u73b0\u4e3a\u53cc\u4fa7\u80ba\u90e8\u6591\u7247\u72b6\u6216\u5f25\u6f2b\u6027\u3001\u5b9e\u53d8\u6216\u8584\u96fe\u6837\u5f711,6,8-10,20-22,26,38\uff08\u56fe2A\uff09\u3002<\/p>\n
\u56fe2. \u9690\u6e90\u6027\u673a\u5316\u6027\u80ba\u708e\uff08COP\uff09\u5404\u79cd\u8868\u73b0\u7684\u80f8\u7247\u548c\u9ad8\u5206\u8fa8\u7387CT\u56fe\u50cf<\/p>\n
\u56feA\u4e2d\u7684\u540e\u524d\u4f4d\u80f8\u7247\u663e\u793a\u53cc\u4fa7\u5f25\u6f2b\u6027\u5b9e\u53d8\u5f71\uff0c\u80ba\u5bb9\u91cf\u6b63\u5e38\u3002\u56feB\u4e2d\u7684\u80f8\u90e8\u9ad8\u5206\u8fa8\u7387CT\uff08HRCT\uff09\u626b\u63cf\u663e\u793a\u4e2d\u3001\u4e0b\u53f6\u5468\u56f4\u548c\u591a\u7076\u5b9e\u53d8\u3002\u56feC\u4e2d\u7684HRCT\u626b\u63cf\u663e\u793a\u5f25\u6f2b\u6027\u5468\u56f4\u7ed3\u8282\u3002\u56feD\u548c\u56feE\u4e2d\u7684HRCT\u626b\u63cf\u663e\u793a\u79fb\u884c\u6027\u5f71\uff1b\u53f3\u4e0a\u53f6\u6591\u7247\u72b6\u3001\u6bdb\u73bb\u7483\u6837\u5f71\uff08D\uff09\uff0c\u4ee5\u53ca1\u4e2a\u6708\u540e\u540c\u4e00\u60a3\u8005\u5728\u65b0\u7684\u533a\u57df\u51fa\u73b0\u6591\u7247\u72b6\u3001\u6bdb\u73bb\u7483\u6837\u5f71\uff08\u56feE\uff09\u3002\u56feF\u4e2d\u7684HRCT\u626b\u63cf\u663e\u793a\u53cd\u6655\u5f81\u6216\u73af\u7901\u5f81\uff0c\u5176\u7279\u5f81\u662f\u8fb9\u7f18\u5b9e\u53d8\uff0c\u4e2d\u5fc3\u900f\u660e\u6216\u6bdb\u73bb\u7483\u6837\u5f71\uff08\u7bad\u5f62\uff09\u3002<\/p>\n
\u75c5\u53d8\u7684\u8303\u56f4\u548c\u4e25\u91cd\u7a0b\u5ea6\u5728\u9ad8\u5206\u8fa8\u7387\u8ba1\u7b97\u673a\u65ad\u5c42\uff08CT\uff09\u80ba\u90e8\u626b\u63cf\u4e2d\u66f4\u4e3a\u660e\u663e\uff0c\u901a\u5e38\u6bd4X\u7ebf\u5e73\u7247\u663e\u793a\u7684\u75c5\u53d8\u66f4\u4e3a\u5e7f\u6cdb\u3002\u9ad8\u5206\u8fa8\u7387CT\u4e3b\u8981\u8868\u73b0\u4e3a\u5468\u56f4\u548c\u591a\u7076\u5b9e\u53d8\uff08\u4f34\u6216\u4e0d\u4f34\u652f\u6c14\u7ba1\u5145\u6c14\u5f81\uff0910,14,23,26,29,33,34,41,45,47,72,73\u3002\u4e0a\u8ff0\u53d1\u73b0\u53ef\u80fd\u4e3a\u5355\u4fa7\uff0c\u4e5f\u53ef\u80fd\u4e3a\u53cc\u4fa7\u3002\u75c5\u53d8\u5206\u5e03\u4e8e\u6240\u6709\u80ba\u533a\uff0c\u80f8\u819c\u4e0b\u53ca\u4e0b\u80ba\u533a\u5206\u5e03\u7565\u591a14,44-46,72\uff08\u56fe2B\uff09\u3002\u5176\u4ed6\u5f71\u50cf\u5b66\u53d1\u73b0\u5305\u62ec\u6bdb\u73bb\u7483\u6837\u5f71\uff1b\u76f4\u5f84\u7ea6\u4e3a8 mm\u7684\u7ed3\u8282\uff08\u6392\u5217\u4e3a\u754c\u9650\u6e05\u695a\u7684\u817a\u6ce1\u72b6\uff09\u6216\u8f83\u5c0f\u7ed3\u8282\uff08\u6392\u5217\u66f4\u4e3a\u7a00\u758f\uff0c\u754c\u9650\u4e0d\u6e05\uff0974\uff08\u56fe2C\uff09\uff1b\u652f\u6c14\u7ba1\u8840\u7ba1\u5468\u56f4\u578b\uff0c\u652f\u6c14\u7ba1\u8840\u7ba1\u675f\u5468\u56f4\u6709\u5b9e\u53d8\u533a74\uff1b\u5e73\u884c\u6216\u5782\u76f4\u4e8e\u80f8\u819c\u7684\u80f8\u819c\u4e0b\u7ebf\u72b6\u548c\u5e26\u72b6\u5f7173,74\uff1b\u4ee5\u53ca\u5c40\u7076\u6027\u75c5\u53d814,33,72\u3002\u75c5\u53d8\u5076\u5c14\u5448\u5c0f\u53f6\u5468\u56f4\u5206\u5e03\uff0c\u4ee5\u8fb9\u754c\u4e0d\u6e05\u3001\u5f13\u5f62\u6216\u591a\u8fb9\u5f62\u5f71\u4e3a\u7279\u5f81\uff0c\u4ee5\u80f8\u819c\u4e0b\u4e3a\u4e3b\uff0c\u88ab\u5145\u6c14\u80ba\u5305\u56f473\u3002\u5f71\u50cf\u5b66\u5f02\u5e38\u4e5f\u53ef\u8868\u73b0\u4e3a\u4f34\u6709\u81ea\u53d1\u6d88\u9000\u533a\u548c\u65b0\u5b9e\u53d8\u533a\u7684\u79fb\u884c\u6027\u5f714,7,9,20,21,23,34,36,41\uff08\u56fe2D\u548c2E\uff09\u3002\u53cd\u6655\u5f81\uff08\u6216\u73af\u7901\u5f81\uff09\u4ee5\u8fb9\u7f18\u5b9e\u53d8\u3001\u4e2d\u5fc3\u900f\u660e\u6216\u6bdb\u73bb\u7483\u6837\u5f71\u4e3a\u7279\u5f81\uff0c\u89c1\u4e8e\u4e0d\u52305%\u7684\u75c5\u4f8b\uff0c\u5e76\u4e14\u5bf9\u673a\u5316\u6027\u80ba\u708e\u4f3c\u4e4e\u5177\u6709\u76f8\u5bf9\u7279\u5f02\u602714,41,46,47,75\uff08\u56fe2F\uff09\u3002\u7eb5\u9694\u6dcb\u5df4\u7ed3\u80bf\u5927\u7684\u60c5\u51b5\u7f55\u89c114,46,47,72\u3002\u636e\u62a5\u9053\uff0c\u5c11\u6570\u75c5\u4f8b\u6709\u5c11\u91cf\u80f8\u8154\u79ef\u6db26,9,11,14,23,41,45,46,72,75\u3002<\/p>\n
\u5728\u968f\u8bbf\u65f6\u7684\u9ad8\u5206\u8fa8\u7387CT\u68c0\u67e5\u4e2d\uff0c\u5b9e\u53d8\u4e0e\u5b9e\u8d28\u5f02\u5e38\u90e8\u5206\u6216\u5b8c\u5168\u6d88\u9000\u76f8\u5173\uff0c\u800c\u7f51\u72b6\u5f71\u53ef\u6301\u7eed\u6216\u8fdb\u5c5535,45\u3002\u8fdb\u884c\u6027\u7ea4\u7ef4\u5316\u548c\u8702\u7a9d\u72b6\u6539\u53d8\u975e\u5e38\u7f55\u89c159,72\u3002\u867d\u7136\u5f71\u50cf\u5b66\u53d1\u73b0\u5b58\u5728\u5dee\u5f02\uff0c\u4f46\u76f8\u5173\u4e34\u5e8a\u80cc\u666f\u4e0b\u7684\u53cc\u4fa7\u80ba\u6ce1\u5f71\u53ef\u652f\u6301\u673a\u5316\u6027\u80ba\u708e\u7684\u8bca\u65ad\u3002<\/p>\n
\u652f\u6c14\u7ba1\u80ba\u6ce1\u704c\u6d17\u6807\u672c\u5206\u6790<\/p>\n
\u5982\u679c\u6000\u7591COP\uff0c\u5efa\u8bae\u5bf9\u652f\u6c14\u7ba1\u80ba\u6ce1\u704c\u6d17\uff08BAL\uff09\u6807\u672c\u8fdb\u884c\u5206\u6790\uff0c\u4ee5\u6392\u9664\u611f\u67d3\u548c\u5176\u4ed6\u75be\u75c5\uff0c\u5982\u55dc\u9178\u6027\u80ba\u708e\u548c\u80ba\u6ce1\u51fa\u8840\u3002BAL\u6807\u672c\u7684\u7ec6\u80de\u5206\u6790\u7ed3\u679c\u5e38\u663e\u793a\u6dcb\u5df4\u7ec6\u80de\u6027\u80ba\u6ce1\u708e\uff0c\u4f34\u6709\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u589e\u52a08,9,11,20-22,24,26,30,32,34,36,40,47,71,76\u3002\u7136\u800c\uff0c\u5b58\u5728\u8fd9\u4e9b\u7ec6\u80de\u7c7b\u578b\u63d0\u793a\u6211\u4eec\u8c03\u67e5\u673a\u5316\u6027\u80ba\u708e\u7684\u7ee7\u53d1\u6027\u539f\u56e0\uff08\u5982\u8fc7\u654f\u6027\u80ba\u708e\u3001\u611f\u67d3\u548c\u55dc\u9178\u6027\u80ba\u708e\uff09\u3002BAL\u68c0\u67e5\u7ed3\u679c\u6062\u590d\u6b63\u5e38\u7684\u65f6\u95f4\u6bd4\u4e34\u5e8a\u548c\u5f71\u50cf\u5b66\u68c0\u67e5\u7ed3\u679c\u6539\u5584\u7684\u65f6\u95f4\u665a76\u3002<\/p>\n
\u7ec4\u7ec7\u75c5\u7406\u5b66\u8bc4\u4f30<\/p>\n
COP\u5e38\u53ef\u5728\u672a\u7ecf\u7ec4\u7ec7\u75c5\u7406\u5b66\u786e\u8ba4\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u6cbb\u7597\u3002\u7136\u800c\uff0c\u5728\u67d0\u4e9b\u75c5\u4f8b\u4e2d\uff0c\u53ef\u80fd\u9700\u8981\u901a\u8fc7\u7ec4\u7ec7\u68c0\u67e5\u6765\u786e\u8ba4\u8bca\u65ad\u3002\u6709\u5173\u6d3b\u68c0\u7684\u51b3\u7b56\u5e94\u8fdb\u884c\u591a\u5b66\u79d1\u8ba8\u8bba\u3002\u7ec4\u7ec7\u5b66\u6539\u53d8\u53ef\u80fd\u63d0\u793a\u7ee7\u53d1\u6027\u673a\u5316\u6027\u80ba\u708e\u7684\u57fa\u7840\u75c5\u56e0\uff08\u5982\u8bef\u5438\u3001\u8840\u7ba1\u708e\u6216\u611f\u67d3\uff0960\u3002\u5728\u672a\u884c\u6d3b\u68c0\u800c\u91c7\u53d6\u6cbb\u7597\u7684\u75c5\u4f8b\u4e2d\uff0c\u5982\u679c\u4e34\u5e8a\u968f\u8bbf\u7ed3\u679c\u4e0eCOP\u8bca\u65ad\u4e0d\u543b\u5408\uff0c\u5e94\u91cd\u65b0\u8bc4\u4f30\uff0c\u800c\u4e14\u53ef\u80fd\u6709\u5fc5\u8981\u8fdb\u884c\u6d3b\u68c0\u3002<\/p>\n
COP\u60a3\u8005\u80ba\u6d3b\u68c0\u6807\u672c\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u7ed3\u679c\u663e\u793a\u8154\u5185\u6709\u758f\u677e\u7ed3\u7f14\u7ec4\u7ec7\u6813\u5b50\uff0c\u7d2f\u53ca\u80ba\u6ce1\u8154\u548c\u80ba\u6ce1\u7ba1\uff0c\u4e5f\u53ef\u7d2f\u53ca\u7ec6\u652f\u6c14\u7ba119\uff08\u56fe3A\u548c3B\uff09\u3002\u80ba\u7684\u57fa\u7840\u7ed3\u6784\u4fdd\u7559\u3002\u8154\u5185\u758f\u677e\u7ed3\u7f14\u7ec4\u7ec7\u6813\u5b50\u5e38\u4ee5\u7ec6\u67c4\u8fde\u63a5\u5230\u80ba\u6ce1\u58c1\uff0c\u5e76\u901a\u8fc7\u80ba\u6ce1\u5b54\u4ece\u4e00\u4e2a\u80ba\u6ce1\u5ef6\u4f38\u5230\u76f8\u90bb\u7684\u80ba\u6ce1\uff0c\u5f62\u6210\u7279\u5f81\u6027\u7684\u8774\u8776\u72b6\u7ed3\u678452\uff08\u56fe3C\uff09\u3002\u80ba\u6ce1\u58c1\u53ef\u51fa\u73b0\u8f7b\u5ea6\u6162\u6027\u708e\u75c7\uff08\u5982\u6d89\u53ca\u6dcb\u5df4\u7ec6\u80de\u548c\u6d46\u7ec6\u80de\uff09\u3002\u7136\u800c\uff0c\u89c2\u5bdf\u5230\u4ee5\u4e0b\u60c5\u51b5\u65f6\uff0c\u63d0\u793a\u6709\u5176\u4ed6\u8bca\u65ad\uff1a\u663e\u8457\u7684\u95f4\u8d28\u6162\u6027\u708e\u75c7\uff08\u6d89\u53ca\u4e2d\u6027\u7c92\u7ec6\u80de\u6216\u55dc\u9178\u6027\u7c92\u7ec6\u80de77\uff09\u3001\u5f62\u6001\u4e0d\u826f\u7684\u8089\u82bd\u80bf\u3001\u7ec6\u652f\u6c14\u7ba1\u5468\u56f4\u5316\u751f\u3001\u6dcb\u5df4\u6837\u805a\u96c6\u3001\u8840\u7ba1\u708e\u3001\u95f4\u8d28\u7ea4\u7ef4\u5316\u6216\u955c\u4e0b\u8702\u7a9d\u72b6\u6539\u53d8\u3002<\/p>\n
\u56fe3. COP\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81<\/p>\n
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\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597<\/p>\n
\u5bf9\u4e8eCOP\u5bfc\u81f4\u547c\u5438\u969c\u788d\u7684\u6709\u75c7\u72b6\u60a3\u8005\uff0c\u5168\u8eab\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u662f\u9996\u9009\u6cbb\u7597\u65b9\u68488,9,14,23,24,26,30,44,71\u3002\u5e38\u89c4\u8d77\u59cb\u5242\u91cf\u4e3a\u6bcf\u65e50.5\uff5e1 mg\/kg\u7684\u6cfc\u5c3c\u677e\uff08\u6839\u636e\u7406\u60f3\u4f53\u91cd\u8ba1\u7b97\u5242\u91cf\uff09\uff0c\u6700\u5927\u5242\u91cf\u4e3a\u6bcf\u65e560 mg\uff08\u6bcf\u65e51\u6b21\u65e9\u6668\u53e3\u670d\uff09\u3002\u4ee5\u4e0a\u8ff0\u8d77\u59cb\u5242\u91cf\u7528\u836f2\uff5e4\u5468\u3002\u6839\u636e\u4e34\u5e8a\u7597\u6548\u5c06\u5242\u91cf\u9010\u6e10\u964d\u4f4e\u81f30.25 mg\/kg\uff0c\u76f4\u81f3\u5b8c\u62104\uff5e6\u4e2a\u6708\u6cbb\u7597\u3002\u5728\u968f\u540e6\uff5e12\u4e2a\u6708\uff0c\u5982\u679c\u60a3\u8005\u75c5\u60c5\u7a33\u5b9a\u6216\u6539\u5584\uff0c\u5219\u5c06\u53e3\u670d\u7cd6\u76ae\u8d28\u6fc0\u7d20\u9010\u6e10\u51cf\u91cf\u81f3\u505c\u836f\u3002<\/p>\n
\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u901a\u5e38\u53ef\u572824\uff5e72\u5c0f\u65f6\u6539\u5584\u60a3\u8005\u75c5\u60c514,32\u3002\u60a3\u8005\u75c7\u72b6\u901a\u5e38\u51cf\u5c11\uff0c\u4e4b\u540e\uff0c\u5f71\u50cf\u5b66\u8868\u73b0\u5728\u8bca\u65ad\u540e3\u4e2a\u6708\u5185\u6d88\u90006,13,14,76\u3002\u5efa\u8bae\u4f7f\u7528\uff1e20 mg\/d\u5242\u91cf\u7684\u6cfc\u5c3c\u677e\u9884\u9632\u8036\u6c0f\u80ba\u5b62\u5b50\u866b\u611f\u67d3\u3002\u5bf9\u4e8e\u5373\u5c06\u53d1\u751f\u547c\u5438\u8870\u7aed\u7684\u91cd\u5ea6\u6216\u5feb\u901f\u8fdb\u5c55\u60a3\u8005\uff0c\u53ef\u80fd\u9700\u8981\u5927\u5242\u91cf\u7532\u6cfc\u5c3c\u677e\uff08\u6bcf\u65e5\u9759\u8109\u7ed9\u836f500\uff5e1,000 mg\uff0c\u7528\u836f3\uff5e5\u65e5\uff09\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\uff0c\u75c5\u60c5\u6539\u5584\uff08\u4e00\u822c\u5728\u6570\u65e5\u5185\uff09\u540e\u53ef\u8f6c\u4e3a\u53e3\u670d\u6cbb\u759745\u3002<\/p>\n
\u636e\u62a5\u9053\u6709\u4e0d\u523025%\u7684\u75c5\u4f8b\u51fa\u73b0\u75be\u75c5\u590d\u53d1\uff08\u5373\u75c7\u72b6\u6076\u5316\uff0c\u6216\u8005\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u671f\u95f4\u6216\u4e4b\u540e\u7684\u80f8\u90e8CT\u626b\u63cf\u663e\u793a\u7279\u5f81\u6027\u65b0\u5f71\u6216\u6b8b\u7559\u5f71\u6076\u5316\uff09\uff0c\u590d\u53d1\u901a\u5e38\u53d1\u751f\u5728\u6700\u521d\u5c31\u8bca\u540e1\u5e74\u51851,6,7,9-11,14,15,23,27,35,38,44,45\u3002\u836f\u7269\u51cf\u91cf\u8fc7\u5feb\u6216\u505c\u836f\u8fc7\u65e9\u65f6\uff0c\u53ef\u51fa\u73b0\u590d\u53d17,27,38,44\u3002\u590d\u53d1\u5927\u591a\u53d1\u751f\u4e8e\u6cfc\u5c3c\u677e\u51cf\u91cf\u81f3\u226415 mg\/d\u540e\u3002\u6709\u51e0\u4e2a\u56e0\u7d20\u4e0e\u590d\u53d1\u76f8\u5173\uff1a\u8bca\u65ad\u65f6\u95f4\u5ef6\u8fdf14,38\uff1b\u542f\u52a8\u6cbb\u7597\u65f6\u95f4\u5ef6\u8fdf\uff08\u51fa\u73b0\u75c7\u72b6\uff1e2\u4e2a\u6708\u540e\uff0938,45\uff1b\u91cd\u5ea6\u75be\u75c5\uff0c\u5305\u62ec\u591a\u7076\u5f719,42,44,46\uff1b\u80f8\u90e8\u5f71\u50cf\u663e\u793a\u7275\u62c9\u6027\u652f\u6c14\u7ba1\u6269\u5f2045\uff1b\u4e00\u6c27\u5316\u78b3\u5f25\u6563\u91cf\u5f02\u5e38\uff08\uff1c\u9884\u6d4b\u503c\u768450%\uff0944\uff1b\u5b58\u5728\u80c6\u6c41\u6de4\u79ef38,48\uff1b\u4f4e\u6c27\u8840\u75c7\uff08\u52a8\u8109\u6c27\u5206\u538b\uff1c70 mmHg\uff0927\uff1b\u80ba\u6ce1\u5185\u7ea4\u7ef4\u86cb\u767d37,42\u6216\u8005\u80cc\u666f\u80ba\u5b9e\u8d28\u7622\u75d5\u5316\u548c\u91cd\u6784\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u8868\u73b025\u3002<\/p>\n
\u590d\u53d1\u7684\u6cbb\u7597\u65b9\u5f0f\u901a\u5e38\u662f\u6062\u590d\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7528\u836f\u6216\u589e\u52a0\u5242\u91cf\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u6cbb\u7597\u590d\u53d1\u65f6\uff0c\u5c0f\u5242\u91cf\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff08\u226420 mg\/d\uff09\u4e0e\u5927\u5242\u91cf\u76f8\u6bd4\uff0c\u7d2f\u79ef\u5242\u91cf\u8f83\u4f4e\uff0c\u526f\u4f5c\u7528\u8f83\u5c11\uff0c\u5e76\u4e14\u4f7f\u7528\u4e24\u79cd\u5242\u91cf\u7684\u5ba2\u89c2\u83b7\u76ca\u76f8\u4f3c38\u3002\u5728COP\u60a3\u8005\u4e2d\uff0c\u590d\u53d1\u4e0e\u53d1\u75c5\u7387\u6216\u6b7b\u4ea1\u7387\u589e\u52a0\u65e0\u517314,38,44,46\u3002<\/p>\n
\u5176\u4ed6\u6cbb\u7597<\/p>\n
\u5bf9\u4e8e\u5168\u8eab\u7cd6\u76ae\u8d28\u6fc0\u7d20\u521d\u59cb\u6cbb\u7597\u672a\u80fd\u6539\u5584\u75c5\u60c5\uff0c\u6216\u8005\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65e0\u6cd5\u9010\u6e10\u51cf\u91cf\u81f3\u5b89\u5168\u6c34\u5e73\uff08\u65e0\u4e0d\u53ef\u63a5\u53d7\u7684\u526f\u4f5c\u7528\uff09\u7684\u60a3\u8005\uff0c\u53ef\u8003\u8651\u5176\u4ed6\u6cbb\u7597\u836f\u7269\u3002<\/p>\n
\u5927\u73af\u5185\u916f\u7c7b\u6297\u751f\u7d20<\/p>\n
\u75c5\u4f8b\u62a5\u544a\u548c\u5c0f\u89c4\u6a21\u56de\u987e\u6027\u75c5\u4f8b\u7cfb\u5217\u7814\u7a76\u63d0\u793a\uff0c\u5728COP\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u6297\u708e\u7279\u6027\u7684\u5927\u73af\u5185\u916f\u7c7b\u6297\u751f\u7d20\uff08\u5982\u7ea2\u9709\u7d20\u6216\u514b\u62c9\u9709\u7d20\uff09\u53ef\u4f5c\u4e3a\u53e3\u670d\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u8f85\u52a9\u65b9\u6848\u6216\u66ff\u4ee3\u65b9\u68481,11,28,44,84\u3002\u5927\u73af\u5185\u916f\u7c7b\u6297\u751f\u7d20\u901a\u5e38\u7528\u836f3\uff5e6\u4e2a\u6708\u6216\u66f4\u957f\u65f6\u95f4\uff0c\u5e76\u5728\u505c\u6b62\u6cbb\u7597\u671f\u95f4\u5bc6\u5207\u76d1\u6d4b\uff0c\u4ee5\u9632\u590d\u53d1\u3002\u9057\u61be\u7684\u662f\uff0c\u5927\u73af\u5185\u916f\u7c7b\u836f\u7269\u4f3c\u4e4e\u4e0d\u5982\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6709\u6548\u3002<\/p>\n
\u7ec6\u80de\u6bd2\u6027\u7597\u6cd5<\/p>\n
\u786b\u5511\u560c\u5464\u6216\u73af\u78f7\u9170\u80fa\u4e0d\u63a8\u8350\u7528\u4e8eCOP\u60a3\u8005\uff0c\u53ea\u6709\u5176\u4ed6\u7597\u6cd5\u5747\u5931\u8d25\u7684\u6781\u5c11\u6570\u60c5\u51b5\u4f8b\u59168,28,30,31,59,71\u3002\u5bf9\u4e8e\u80be\u529f\u80fd\u6b63\u5e38\u7684\u60a3\u8005\uff0c\u786b\u5511\u560c\u5464\u7684\u8d77\u59cb\u5242\u91cf\u4e3a\u6bcf\u65e51\uff5e2 mg\/kg\uff08\u6bcf\u65e51\u6b21\u53e3\u670d\uff09\uff0c\u6700\u5927\u5242\u91cf\u4e3a\u6bcf\u65e5150 mg\u3002\u5efa\u8bae\u4ece\u6bcf\u65e550 mg\u7684\u5242\u91cf\u5f00\u59cb\uff0c\u57282\uff5e4\u5468\u671f\u95f4\u7f13\u6162\u589e\u52a0\u5242\u91cf\uff0c\u6cbb\u7597\u6301\u7eed\u81f3\u5c113\u4e2a\u6708\u3002\u8003\u8651\u5230\u73af\u78f7\u9170\u80fa\u7684\u76f8\u5173\u6bd2\u6027\u4f5c\u7528\uff0c\u5e94\u57286\u4e2a\u6708\u540e\u505c\u836f71\u3002<\/p>\n
\u5417\u66ff\u9ea6\u8003\u915a\u916f\u548c\u5176\u4ed6\u836f\u7269 <\/p>\n
\u5417\u66ff\u9ea6\u8003\u915a\u916f\u662f\u6dcb\u5df4\u7ec6\u80de\u589e\u6b96\u6291\u5236\u5242\uff0c\u5728\u7ea4\u7ef4\u5316\u80ba\u75be\u75c5\uff08\u5305\u62ecCOP\uff09\u6cbb\u7597\u4e2d\uff0c\u8d8a\u6765\u8d8a\u591a\u5730\u88ab\u7528\u4f5c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u52a9\u51cf\u524231,81\u3002\u5728\u75c5\u4f8b\u62a5\u544a\u4e2d\uff0c\u73af\u5b62\u7d2085,86\u3001\u5229\u59a5\u6614\u5355\u629787\u548c\u9759\u8109\u7ed9\u4e88\u514d\u75ab\u7403\u86cb\u767d88\u4e5f\u88ab\u7528\u4e8e\u6cbb\u7597\u5feb\u901f\u8fdb\u5c55\u6027\u75be\u75c5\u6216\u7cd6\u76ae\u8d28\u6fc0\u7d20\u8010\u836f\u6027\u673a\u5316\u6027\u80ba\u708e\uff08\u901a\u5e38\u4e0e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5408\u7528\uff09\uff0c\u5e76\u83b7\u5f97\u4e86\u6709\u9650\u7684\u6210\u529f\u3002<\/p>\n
\u9884\u540e<\/p>\n
COP\u60a3\u8005\u7684\u9884\u540e\u548c\u6cbb\u7597\u6548\u679c\u4e00\u822c\u90fd\u5f88\u597d\u3002\u5f71\u50cf\u5b66\u4e0a\u6709\u6c14\u8154\u5f71\u7684\u60a3\u8005\u6bd4\u6709\u7f51\u72b6\u5f71\u7684\u60a3\u8005\u9884\u540e\u597d\u5f97\u591a23,25,35,46\u3002\u5bf9\u4e8e\u4f4f\u9662\u60a3\u8005\uff0c\u4f4f\u9662\u65f6\u95f4\u901a\u5e38\u4e0d\u52303\u5468\uff1b\u75be\u75c5\u5f97\u5230\u786e\u8bca\u5e76\u542f\u52a8\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u540e\uff0c\u75c5\u60c5\u901a\u5e38\u5feb\u901f\u6539\u5584\uff08\u901a\u5e38\u572872\u5c0f\u65f6\u5185\uff0c\u5f88\u5c11\uff1e10\u65e5\uff0914\u3002<\/p>\n
\u5728\u673a\u5316\u6027\u80ba\u708e\u60a3\u8005\u4e2d\uff0c\u9700\u8981\u673a\u68b0\u901a\u6c14\u5e76\u5bfc\u81f4\u6b7b\u4ea1\u7684\u8fdb\u884c\u6027\u547c\u5438\u8870\u7aed\u7f55\u89c16,16,30\u3002\u5728\u5927\u591a\u6570\u56de\u987e\u6027\u7814\u7a76\u4e2d\uff0c\u56e0COP\u6b7b\u4ea1\u7684\u60a3\u8005\u6bd4\u4f8b\uff1c10%\uff0c\u800c\u4e14\u6b7b\u4ea1\u539f\u56e0\u901a\u5e38\u4e0eCOP\u65e0\u51731,6-11,14,19-21,23-32,34-38,41-46\u30025\u5e74\u751f\u5b58\u7387\u8d85\u8fc790%\u3002\u7136\u800c\uff0cCOP\u60a3\u8005\u7684\u6b7b\u4ea1\u7387\u9ad8\u4e8e\u4e00\u822c\u4eba\u7fa46,16\u3002\u5728\u7ee7\u53d1\u6027\u673a\u5316\u6027\u80ba\u708e\u60a3\u8005\u4e2d\uff0c\u6b7b\u4ea1\u7387\u8f83\u9ad8\uff0c\u6b7b\u56e0\u901a\u5e38\u662f\u57fa\u7840\u75be\u75c56,14,27\u3002<\/p>\n
\u672a\u6765\u65b9\u5411<\/p>\n
COP\u7684\u53d1\u75c5\u7387\u548c\u60a3\u75c5\u7387\u4ecd\u4e0d\u660e\u786e\u3002\u7136\u800c\uff0c\u9274\u4e8e\u6211\u4eec\u5bf9\u8be5\u75be\u75c5\u7684\u5b9a\u4e49\u5df2\u6709\u6240\u6539\u8fdb\uff0c\u5728\u7279\u53d1\u6027\u95f4\u8d28\u6027\u80ba\u708e\u767b\u8bb0\u7cfb\u7edf\u4e2d\u6301\u7eed\u524d\u77bb\u6027\u6536\u96c6\u6570\u636e\u5e94\u8be5\u53ef\u4ee5\u9610\u660e\u4e0a\u8ff0\u95ee\u9898\u3002\u6211\u4eec\u9700\u8981\u5f00\u5c55\u66f4\u591a\u7814\u7a76\u6765\u533a\u5206\u539f\u53d1\u6027COP\u548c\u7ee7\u53d1\u6027\u673a\u5316\u6027\u80ba\u708e\u3002\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u5242\u91cf\u548c\u7528\u836f\u6301\u7eed\u65f6\u95f4\u4ecd\u4e0d\u660e\u786e\uff0c\u514d\u75ab\u6291\u5236\u6cbb\u7597\u4f5c\u4e3a\u521d\u7ea7\u6216\u4e8c\u7ea7\u6cbb\u7597\u7684\u6548\u679c\u5c1a\u4e0d\u6e05\u695a\u3002\u5982\u679c\u53ef\u4ee5\u7406\u6e05\u673a\u5316\u6027\u80ba\u708e\u53d1\u75c5\u548c\u6d88\u9000\u7684\u7ec6\u80de\u548c\u5206\u5b50\u673a\u5236\uff0c\u90a3\u4e48\u5bf9\u4e8eUIP\u4e2d\u6301\u7eed\u8fdb\u5c55\u4e14\u4e0d\u53ef\u9006\u7684\u7ea4\u7ef4\u5316\u75c5\u53d8\uff0c\u6211\u4eec\u53ef\u80fd\u53ef\u4ee5\u66f4\u597d\u5730\u786e\u5b9a\u5371\u9669\u56e0\u7d20\u548c\u6cbb\u7597\u7b56\u7565\u3002\u5c24\u5176\u662f\u5982\u679c\u53ef\u4ee5\u4e86\u89e3\u6210\u7ea4\u7ef4\u7ec6\u80de\u7076\u548cMasson\u5c0f\u4f53\u4e4b\u95f4\u7684\u533a\u522b\uff0c\u6211\u4eec\u53ef\u80fd\u53ef\u4ee5\u4e3a\u673a\u5316\u6027\u80ba\u708e\u548cUIP\u5236\u5b9a\u66f4\u597d\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n
\u4f5c\u8005\u4fe1\u606fTalmadge E. King, Jr., M.D., and Joyce S. Lee, M.D.From the University of California, San Francisco (T.E.K.); and the University of Colorado Anschutz Medical Campus, Aurora (J.S.L.). Dr. King can be contacted at talmadge.king@ucsf.edu or at the School of Medicine, University of California San Francisco, 513 Parnassus Ave., Box 0410, San Francisco, CA 94143.\u53c2\u8003\u6587\u732e<\/p>\n
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