{"id":48402,"date":"2025-03-04T05:19:23","date_gmt":"2025-03-04T05:19:23","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=48402"},"modified":"2025-03-04T05:19:23","modified_gmt":"2025-03-04T05:19:23","slug":"5%e4%b8%aa%e4%bf%9d%e6%8a%a4%e8%82%be%e8%84%8f%e3%80%81%e9%99%8d%e4%bd%8e%e5%b0%bf%e8%9b%8b%e7%99%bd%e7%9a%84%e4%b8%ad%e6%88%90%e8%8d%af%ef%bc%8c%e4%b8%80%e6%96%87%e6%80%bb%e7%bb%93%ef%bc%9a","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=48402","title":{"rendered":"5\u4e2a\u4fdd\u62a4\u80be\u810f\u3001\u964d\u4f4e\u5c3f\u86cb\u767d\u7684\u4e2d\u6210\u836f\uff0c\u4e00\u6587\u603b\u7ed3\uff1a"},"content":{"rendered":"

1\u3001\u6d77\u6606\u80be\u559c\u80f6\u56ca\uff1a<\/p>\n

\u672c\u836f\u662f\u7531\u6d77\u6d0b\u690d\u7269\u63d0\u53d6\u7684\u7eaf\u5929\u7136\u6d77\u6d0b\u836f\u7269\uff0c\u5176\u4e3b\u8981\u6210\u5206\u8910\u85fb\u591a\u7cd6\u786b\u9178\u916f(FPS)\u662f\u4e00\u79cd\u6c34\u6eb6\u6027\u6742\u805a\u7cd6\uff0c\u542b\u6709\u5f3a\u6781\u6027\u7684\u6d3b\u6027\u57fa\u56e0\u786b\u9178\u916f\uff0c\u662f\u4e00\u79cd\u5f3a\u5438\u9644\u5242\uff0c\u53ef\u5145\u5206\u5438\u9644\u4f53\u5185\u7684\u4e00\u4e9b\u6bd2\u6027\u7269\u8d28\uff0c\u4f7f\u5176\u6392\u51fa\u4f53\u5916\u3002\u540c\u65f6\u53ef\u6539\u5584\u80be\u8840\u6d41\uff0c\u6e05\u9664\u6d3b\u6027\u81ea\u7531\u57fa\uff0c\u5177\u6709\u6297\u6c27\u5316\u4f5c\u7528\uff0c\u80fd\u5ef6\u7f13\u80be\u5c0f\u7403\u75c5\u53d8\u53d1\u5c55\u3002\u8910\u85fb\u591a\u7cd6\u786b\u9178\u916f\u662f\u591a\u7cd6\u7c7b\u5316\u5408\u7269\uff0c\u5177\u6709\u6297\u51dd\u3001\u964d\u8840\u538b\u3001\u964d\u8840\u8102\u3001\u6297\u764c\u548c\u514d\u75ab\u8c03\u8282\u7b49\u591a\u65b9\u9762\u751f\u7269\u6d3b\u6027\u3002\u5176\u5185\u542b\u80be\u5c0f\u7403\u6ee4\u819c\u4fee\u590d\u56e0\u5b50\uff0c\u5c3f\u4fc3\u8fdb\u6d3b\u6027\u7d20\uff0c\u76f4\u63a5\u4f5c\u7528\u4e8e\u75c5\u60a3\u5904\uff0c\u4fc3\u8fdb\u80be\u5c0f\u7403\u6ee4\u819c\u4fee\u590d\uff0c\u6062\u590d\u5176\u901a\u900f\u6027\uff0c\u80fd\u53ca\u65f6\u6392\u51fa\u4f53\u5185\u6bd2\u7d20\u53ca\u4fee\u590d\u574f\u6b7b\u80be\u7ec4\u7ec7\u3002\u8be5\u836f\u5bf9\u80be\u810f\u7684\u4fdd\u62a4\u673a\u5236\u53ef\u80fd\u4e0e\u80be\u810f\u7ec6\u80de\u5185\u57fa\u8d28\u2163\u578b\u80f6\u539f\u548c\u7ea4\u7ef4\u86cb\u767d\u5408\u6210\uff0c\u51cf\u5c11\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u7269\u6291\u5236\u72691(PAI-1)\u3001\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2(TGF-\u03b2\uff09\u8868\u8fbe\uff0c\u800c\u6291\u5236\u57fa\u8d28\u6c89\u79ef\uff0c\u5ef6\u7f13\u548c\u9632\u6cbb\u80be\u5c0f\u7403\u786c\u5316\u6709\u5173\u3002<\/p>\n

2\u3001\u590d\u65b9\u4e39\u53c2\u6ef4\u4e38\uff1a<\/p>\n

\u672c\u836f\u7531\u4e39\u53c2\u3001\u4e09\u4e03\u3001\u51b0\u7247\u7ec4\u6210\uff0c\u4e2d\u836f\u836f\u7406\u7814\u7a76\u8bc1\u660e\uff0c\u4e39\u53c2\u80fd\u4f7f\u8840\u5c0f\u677f\u89e3\u805a\uff0c\u6291\u5236\u51dd\u8840\u529f\u80fd\uff0c\u4fc3\u8fdb\u7ea4\u6eb6\u7cfb\u7edf\u529f\u80fd\uff0c\u6539\u5584\u5faa\u73af\u72b6\u6001\uff0c\u589e\u5f3a\u8840\u6d41\u52a8\u529b\uff1b\u4e09\u4e03\u53ef\u6291\u5236\u8840\u5c0f\u677f\u805a\u96c6\uff0c\u4fc3\u8fdb\u5168\u8840\u9ecf\u7a20\u5ea6\u4e0b\u964d\uff0c\u5177\u6709\u964d\u4f4e\u5c3f\u86cb\u767d\uff0c\u5ef6\u7f13\u6162\u6027\u80be\u75c5\u53d1\u5c55\u7684\u4f5c\u7528\u3002\u52a8\u7269\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u590d\u65b9\u4e39\u53c2\u6ef4\u4e38\u80fd\u591f\u6709\u6548\u5730\u964d\u4f4e\u65e9\u671f\u7cd6\u5c3f\u75c5\u80be\u75c5\u5927\u9f20\u7684\u5c3f\u5fae\u91cf\u767d\u86cb\u767d\uff0c\u51cf\u8f7b\u80be\u5c0f\u7403\u80a5\u5927\u7684\u7a0b\u5ea6\uff1b\u4e2d\u7b49\u53ca\u5927\u5242\u91cf\u5e94\u7528\u65f6\u80fd\u591f\u964d\u4f4e\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u53ca\u8840\u7cd6\u6c34\u5e73\u3002<\/p>\n

\u73b0\u4ee3\u533b\u5b66\u7814\u7a76\u8bc1\u660e\uff0c\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u5316\u9176\u6291\u5236\u5242 (ACEI) \u6216\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u9176\u53d7\u4f53\u62ee\u6297\u5242 (ARB) \u80fd\u964d\u4f4e\u5c3f\u5fae\u91cf\u6e05\u86cb\u767d\u6392\u6cc4\u7387\uff0c\u5e76\u80fd\u6709\u6548\u5730\u9006\u8f6c\u53ca\u5ef6\u7f13\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u8fdb\u5c55\u3002\u86cb\u767d\u5c3f\u662f\u5faa\u73af\u52a8\u529b\u5b66\u548c\u4ee3\u8c22\u56e0\u7d20\u8bf1\u53d1\u7684\u80be\u810f\u635f\u4f24\u7684\u654f\u611f\u6307\u6807\uff0c\u662f\u8bca\u65ad\u6162\u6027\u80be\u75c5\u7684\u91d1\u6807\u51c6\uff0c\u662f\u786e\u5b9a\u80be\u5c0f\u7403\u6bdb\u7ec6\u8840\u7ba1\u635f\u5bb3\u7684\u91cd\u8981\u6807\u5fd7\uff0c\u5e76\u53cd\u6620\u5168\u8eab\u8840\u7ba1\u5185\u76ae\u7684\u635f\u5bb3\uff0c\u662f\u6162\u6027\u80be\u75c5\u8fdb\u5c55\u7684\u6700\u5371\u9669\u56e0\u7d20\u53ca\u9884\u6d4b\u4e34\u5e8a\u671f\u80be\u75c5\u3001\u80be\u8870\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4e00\u4e2a\u91cd\u8981\u6307\u6807\u3002\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\uff0c\u5728ACEI (ARB) \u7b49\u5e38\u89c4\u6cbb\u7597\u7684\u57fa\u7840\u4e0a\uff0c\u52a0\u7528\u590d\u65b9\u4e39\u53c2\u6ef4\u4e38\u4e0d\u4f46\u80fd\u663e\u8457\u964d\u4f4e\u86cb\u767d\u5c3f\uff0c\u4e5f\u80fd\u6709\u6548\u6539\u5584\u8840\u8102\u6c34\u5e73\u3002<\/p>\n

3\u3001\u96f7\u516c\u85e4\u591a\u82f7\u7247\uff1a<\/p>\n

\u96f7\u516c\u85e4\u662f\u5de5\u77db\u79d1\u96f7\u516c\u85e4\u5c5e\u690d\u7269\uff0c\u662f\u4e00\u79cd\u5177\u6709\u6e05\u70ed\u89e3\u6bd2\u3001\u795b\u98ce\u901a\u7edc\u3001\u8212\u7b4b\u6d3b\u8840\u3001\u9664\u6e7f\u53bb\u80bf\u6b62\u75db\u7684\u4e2d\u836f\uff0c\u4f5c\u4e3a\u514d\u75ab\u6291\u5236\u5242\u5e7f\u6cdb\u5e94\u7528\u4e8e\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u6162\u6027\u80be\u5c0f\u7403\u80be\u708e\u3001\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u54ee\u5598\u3001\u76ae\u80a4\u75c5\u7b49\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u96f7\u516c\u85e4\u591a\u82f7\u662f\u4ece\u96f7\u516c\u85e4\u4e2d\u63d0\u53d6\u7cbe\u5236\u800c\u6210\uff0c \u836f\u7528\u4e3b\u8981\u662f\u53bb\u4e8c\u5c42\u76ae\u7684\u6839\u6728\u8d28\u90e8\u96f7\u516c\u85e4\u7532\u7d20 (\u96f7\u516c\u85e4\u5185\u916f\u9187) \uff0c\u662f\u5176\u4e3b\u8981\u6709\u6548\u6210\u5206\u3002\u96f7\u516c\u85e4\u591a\u82f7\u964d\u4f4e\u86cb\u767d\u5c3f\u7684\u4f5c\u7528\u673a\u5236\u53ef\u80fd\u662f\u5b83\u6d88\u9664\u57fa\u5e95\u819c\u4e0a\u514d\u75ab\u590d\u5408\u7269\uff0c\u589e\u5f3a\u6bdb\u7ec6\u8840\u7ba1\u58c1\u9634\u7535\u8377\uff0c\u4fdd\u62a4\u548c\u4fee\u590d\u80be\u5c0f\u7403\u57fa\u5e95\u819c\u86cb\u767d\uff0c\u7ef4\u7279\u5176\u7535\u8377\u5c4f\u969c\u7684\u5b8c\u6574\u6027\uff0c\u6539\u5584\u80be\u5c0f\u7403\u6ee4\u8fc7\u819c\u901a\u900f\u6027\u548c\u6291\u5236\u7cfb\u819c\u589e\u751f\uff0c\u53e6\u5916\uff0c\u96f7\u516c\u85e4\u591a\u82f7\u4f5c\u7528\u673a\u5236\uff0c \u5305\u62ec\u8bf1\u5bfcT\u7ec6\u80de\u51cb\u4ea1\uff0c\u6291\u5236\u7ec6\u80de\u6838\u56e0\u5b50kB (NK-kB) \uff0c\u6291\u5236T\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u6291\u5236\u767d\u4ecb\u7d20-2\u4ea7\u751f\u7b49\uff0c\u5176\u4e2d\u96f7\u516c\u85e4\u5185\u8102\u53ef\u5f71\u54cdc-fos\/c-jun\u57fa\u56e0\u8f6c\u5f55\uff0c\u6291\u5236\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u751f\u957f\u56e0\u5b50mRNA\u8868\u8fbe\u53ca\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u5408\u6210\uff0c\u4ece\u800c\u964d\u4f4e\u86cb\u767d\u5c3f\u7684\u4ea7\u751f\u3002<\/p>\n

4\u3001\u6606\u4ed9\u80f6\u56ca\uff1a<\/p>\n

\u672c\u836f\u7531\u6606\u660e\u5c71\u6d77\u68e0\u3001\u6deb\u7f8a\u85ff\u3001\u83df\u4e1d\u5b50\u3001\u67b8\u675e\u5b50\u56db\u5473\u836f\u7269\u7ec4\u6210\u3002\u5177\u6709\u8865\u80be\u901a\u7edc\uff0c\u795b\u98ce\u9664\u6e7f\u529f\u6548\u3002\u65b9\u4e2d\u7684\u6606\u660e\u5c71\u6d77\u68e0\u4e0e\u96f7\u516c\u85e4\u76f8\u4f3c\uff0c\u6240\u542b\u6d3b\u6027\u6210\u5206\u5341\u5206\u590d\u6742\uff0c\u4e14\u6d3b\u6027\u5f3a\u800c\u91cf\u5fae\uff0c\u4e3b\u8981\u542b\u6709\u591a\u79cd\u4e8c\u841c\u5185\u916f\u3001\u751f\u7269\u78b1\u3001\u4e09\u841c\u7b49\u6d3b\u6027\u7269\u8d28\u3002\u836f\u7406\u7814\u7a76\u8868\u660e\u6606\u660e\u5c71\u6d77\u68e0\u5177\u6709\u6539\u5584\u5faa\u73af\uff0c\u5177\u6709\u6fc0\u7d20\u6837\u4f5c\u7528\u800c\u65e0\u6fc0\u7d20\u526f\u4f5c\u7528\uff0c\u5177\u6709\u6d88\u708e\u548c\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u53ef\u589e\u52a0\u80be\u8840\u6d41\u91cf\u3001\u964d\u4f4e\u80be\u5c0f\u7403\u6bdb\u7ec6\u8840\u7ba1\u901a\u900f\u6027\uff0c\u6539\u5584\u53d7\u635f\u7ec4\u7ec7\u8840\u6db2\u4f9b\u5e94\uff0c\u4ece\u800c\u4f7f\u80be\u5c0f\u7403\u57fa\u5e95\u819c\u6f0f\u8fc7\u86cb\u767d\u51cf\u5c11\uff0c\u80be\u5c0f\u7ba1\u91cd\u5438\u6536\u4f5c\u7528\u589e\u52a0\u8fbe\u5230\u6d88\u9664\u86cb\u767d\u5c3f\u7684\u4f5c\u7528\u3002\u53e6\u52a8\u7269\u5b9e\u9a8c\u8bc1\u660e\u6606\u660e\u5c71\u6d77\u68e0\u80fd\u663e\u8457\u6539\u5584\u964d\u4f4e\u5b9e\u9a8c\u52a8\u726924h\u5c3f\u86cb\u767d\u542b\u91cf\u53ca\u8840\u6e05\u5c3f\u7d20\u6c2e\uff0c\u5347\u9ad8\u8840\u6e05\u767d\u86cb\u767d\u3001\u603b\u86cb\u767d\uff0c\u6539\u5584\u80be\u529f\u80fd\u53ca\u80be\u5c0f\u7403\u7684\u75c5\u7406\u53d8\u5316\u3002\u53d6\u6deb\u7f8a\u85ff\u6e29\u8865\u80be\u9633\u4e4b\u529f\uff0c\u76ca\u80be\u586b\u7cbe\uff0c\u771f\u9633\u5f97\u8865\uff0c\u8bf8\u75c7\u81ea\u89e3\u3002\u5b9e\u9a8c\u8bc1\u660e\uff0c\u6deb\u7f8a\u85ff\u603b\u9ec4\u916e\u53ef\u4f7f\u9633\u865a\u8bc1\u52a8\u7269\u4f4e\u4e0b\u7684\u4f53\u6db2\u514d\u75ab\u529f\u80fd\u6062\u590d\u3002\u5168\u65b9\u5171\u594f\u6ecb\u8865\u809d\u80be\u3001\u56fa\u6da9\u80be\u7cbe\u4e4b\u529f\u3002<\/p>\n

5\u3001\u80be\u708e\u5eb7\u590d\u7247\uff1a<\/p>\n

\u672c\u836f\u836f\u7269\u7ec4\u6210\u4e3a\u897f\u6d0b\u53c2\u3001\u767d\u82b1\u86c7\u820c\u8349\u3001\u675c\u4ef2\u3001\u4eba\u53c2\u3001\u4e39\u53c2\u3001\u571f\u832f\u82d3\u3001\u751f\u5730\u9ec4\u7b49\u3002\u5176\u4e2d\u4eba\u53c2\u3001\u897f\u6d0b\u53c2\u5177\u6709\u964d\u8840\u7cd6\uff0c\u8c03\u8840\u8102\uff0c\u6539\u5584\u80be\u810f\u8840\u6db2\u6d41\u53d8\u5b66\u6307\u6807\u4f5c\u7528\uff1b\u4e39\u53c2\u5177\u6709\u6539\u5584\u8840\u6db2\u5faa\u73af\u3001\u589e\u52a0\u80be\u8840\u6d41\u4f5c\u7528\uff0c\u53ef\u51cf\u5c11\u86cb\u767d\u5c3f\uff0c\u5ef6\u7f13\u80be\u529f\u80fd\u6076\u5316\uff1b\u675c\u4ef2\u3001\u767d\u82b1\u86c7\u820c\u8349\u3001\u571f\u832f\u82d3\u53ef\u6539\u5584\u80be\u810f\u5fae\u5faa\u73af\uff0c\u6297\u708e\uff0c\u6539\u5584\u7cd6\u4ee3\u8c22\uff0c\u589e\u52a0\u80be\u810f\u8840\u6d41\u704c\u6ce8\uff0c\u514d\u75ab\u8c03\u8282\u53ca\u51cf\u8f7b\u5c3f\u86cb\u767d\u4f5c\u7528\u3002\u751f\u5730\u9ec4\u53ef\u964d\u4f4e\u8840\u7cd6\uff0c\u6539\u5584\u5fae\u5faa\u73af\uff0c\u589e\u52a0\u80be\u8840\u6d41\u91cf\uff0c\u6539\u5584\u7cd6\u4ee3\u8c22\u7d0a\u4e71\uff0c\u51cf\u5c11\u5c3f\u86cb\u767d\uff0c\u4fdd\u62a4\u80be\u810f\uff0c\u51cf\u8f7b\u708e\u75c7\u3002\u5b9e\u9a8c\u7814\u7a76\u8868\u660e\uff0c\u80be\u708e\u5eb7\u590d\u7247\u53ef\u51cf\u5c11\u80be\u75c5\u5927\u9f20\u80be\u810f\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u6c89\u79ef\uff0c\u6709\u964d\u4f4e\u6bdb\u7ec6\u8840\u7ba1\u901a\u900f\u6027\u3001\u6297\u708e\u3001\u5229\u5c3f\u4f5c\u7528\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

1\u3001\u6d77\u6606\u80be\u559c\u80f6\u56ca\uff1a \u672c\u836f\u662f\u7531\u6d77\u6d0b\u690d\u7269\u63d0\u53d6\u7684\u7eaf\u5929\u7136\u6d77\u6d0b\u836f\u7269\uff0c\u5176\u4e3b\u8981\u6210\u5206\u8910\u85fb\u591a\u7cd6\u786b\u9178 … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-48402","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/48402","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=48402"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/48402\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=48402"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=48402"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=48402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}