\u3010\u901a\u7528\u540d\u79f0\u3011\u6cd5\u745e\u897f\u5355\u6297\u6ce8\u5c04\u6db2<\/p>\n
\u3010\u5546\u54c1\u540d\u79f0\u3011\u4e2d\u6587\uff1a\u7f57\u89c6\u4f73\u00ae\uff1b\u82f1\u6587\uff1aVABYSMO\u00ae<\/p>\n
\u3010\u82f1\u6587\u540d\u79f0\u3011Faricimab Injection<\/p>\n
\u3010\u6c49\u8bed\u62fc\u97f3\u3011Faruixi Dankang Zhusheye<\/p>\n
\u3010\u6210\u4efd\u3011\u6d3b\u6027\u6210\u4efd\uff1a\u6cd5\u745e\u897f\u5355\u6297<\/p>\n
\u6cd5\u745e\u897f\u5355\u6297\u662f\u4e00\u79cd\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u548c\u8840\u7ba1\u751f\u6210\u7d20-2\uff08Ang-2\uff09\u7684\u4eba\u6e90\u5316\u53cc\u7279\u5f02\u6027\u514d\u75ab\u7403\u86cb\u767d G1\uff08IgG1\uff09\u6297\u4f53\uff0c\u7531\u4e2d\u56fd\u4ed3\u9f20\u5375\u5de2\uff08CHO\uff09\u7ec6\u80de\u901a\u8fc7DNA \u91cd\u7ec4\u6280\u672f\u5236\u5f97\u3002<\/p>\n
\u8f85\u6599\uff1a\u7ec4\u6c28\u9178\u300130%\u918b\u9178\u3001\u7532\u786b\u6c28\u9178\u3001\u6c2f\u5316\u94a0\u3001\u8517\u7cd6\u548c\u805a\u5c71\u68a8\u916f 20<\/p>\n
\u3010\u6027\u72b6\u3011\u6f84\u6e05\u81f3\u4e73\u5149\u3001\u65e0\u8272\u81f3\u68d5\u9ec4\u8272\u6eb6\u6db2\u3002<\/p>\n
\u3010\u9002\u5e94\u75c7\u3011\u672c\u54c1\u662f\u4e00\u79cd\u53cc\u7279\u5f02\u6027 VEGF \u548c Ang-2 \u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\uff1a<\/p>\n
\u25cf\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\uff08DME\uff09<\/p>\n
\u25cf\u65b0\u751f\u8840\u7ba1\u6027\uff08\u6e7f\u6027\uff09\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08nAMD\uff09<\/p>\n
\u3010\u89c4\u683c\u30110.05ml\uff086mg\uff09\/\u74f6<\/p>\n
\u3010\u7528\u6cd5\u7528\u91cf\u3011\u4e00\u822c\u7ed9\u836f\u4fe1\u606f <\/p>\n
\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u3002\u672c\u54c1\u5e94\u7531\u5177\u5907\u8d44\u8d28\u7684\u533b\u751f\u7ed9\u836f\u3002\u6bcf\u74f6\u836f\u7269\u4ec5\u4f9b\u5355\u773c\u6cbb\u7597\u3002<\/p>\n
\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\uff08DME\uff09<\/p>\n
\u5efa\u8bae\u6839\u636e\u4ee5\u4e0b\u4e24\u79cd\u7ed9\u836f\u65b9\u6848\u4e2d\u7684\u4e00\u79cd\u8fdb\u884c\u7ed9\u836f\uff1a<\/p>\n
1\u3001\u4e00\u6b21 6mg\uff08\u76f8\u5f53\u4e8e 0.05 ml\uff09\uff0c\u6bcf 4 \u5468\uff08\u7ea6\u6bcf 28 \u5929\u00b17 \u5929\u4e00\u6b21\uff0c\u6bcf\u6708\u4e00\u6b21\uff09\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u7ed9\u836f\u4e00\u6b21\uff0c\u81f3\u5c11\u7ed9\u836f 4 \u6b21\u3002\u5b8c\u6210\u81f3\u5c11 4 \u6b21\u7ed9\u836f\u540e\uff0c\u5982\u679c\u6839\u636e\u5149\u5b66\u76f8\u5e72\u65ad\u5c42\u626b\u63cf\uff08OCT\uff09\u6d4b\u5f97\u7684\u9ec4\u6591\u4e2d\u5fc3\u51f9\u89c6\u7f51\u819c\u539a\u5ea6\uff08CST\uff09\u786e\u5b9a\u6c34\u80bf\u6d88\u9000\uff0c\u53ef\u6839\u636e CST\u548c\u89c6\u529b\u8bc4\u4f30\u7ed3\u679c\u8c03\u6574\u7ed9\u836f\u95f4\u9694\uff0c\u5982\u75c5\u60c5\u7a33\u5b9a\uff0c\u53ef\u9010\u6b65\u5ef6\u957f\u7ed9\u836f\u95f4\u9694\u81f3\u6bcf 16 \u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u6bcf\u6b21\u5ef6\u957f\u4e0d\u8d85\u8fc7 4 \u5468\uff1b\u5982\u75c5\u60c5\u51fa\u73b0\u6076\u5316\uff0c\u5219\u5e94\u7f29\u77ed\u7ed9\u836f\u95f4\u9694\uff0c\u6bcf\u6b21\u7f29\u77ed\u4e0d\u8d85\u8fc78 \u5468\u3002<\/p>\n
2\u3001\u4e00\u6b216mg\uff08\u76f8\u5f53\u4e8e0.05 ml\uff09\uff0c\u6bcf 4 \u5468\uff08\u7ea6\u6bcf 28 \u5929\u00b17 \u5929\u4e00\u6b21\uff0c\u6bcf\u6708\u4e00\u6b21\uff09\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u7ed9\u836f\u4e00\u6b21\uff0c\u8fde\u7eed\u7ed9\u836f 6 \u6b21\uff0c\u968f\u540e\u4ee5 6 mg \u5242\u91cf\u6bcf 8 \u5468\uff082 \u4e2a\u6708\uff09\u7ed9\u836f\u4e00\u6b21\u3002<\/p>\n
\u6ce8\uff1a\u5c3d\u7ba1\u4e0e\u6bcf 8 \u5468\u4e00\u6b21\u7ed9\u836f\u65b9\u6848\u76f8\u6bd4\uff0c\u6309\u7167\u6bcf 4 \u5468\u4e00\u6b21\u65b9\u6848\u7ed9\u836f\u540e\u5728\u5927\u591a\u6570\u60a3\u8005\u4e2d\u672a\u89c1\u7597\u6548\u63d0\u9ad8\uff0c\u4f46\u5728\u5b8c\u6210\u524d 4 \u6b21\u7ed9\u836f\u540e\u4ecd\u53ef\u80fd\u9700\u8981\u7ee7\u7eed\u6309\u7167\u539f\u6765\u7684\u6bcf 4 \u5468\u4e00\u6b21\uff08\u6bcf\u6708\u4e00\u6b21\uff09\u7ed9\u836f\u65b9\u6848\u5bf9\u4e00\u4e9b\u60a3\u8005\u8fdb\u884c\u6cbb\u7597\u3002\u5e94\u5b9a\u671f\u5bf9\u60a3\u8005\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n
\u65b0\u751f\u8840\u7ba1\u6027\uff08\u6e7f\u6027\uff09\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08nAMD\uff09<\/p>\n
\u672c\u54c1\u7684\u63a8\u8350\u5242\u91cf\u4e3a\u4e00\u6b21 6 mg\uff08\u76f8\u5f53\u4e8e 0.05 ml\uff09\uff0c\u6bcf 4 \u5468\uff08\u7ea6\u6bcf 28\u00b17 \u5929\u4e00\u6b21\uff0c\u6bcf\u6708\u4e00\u6b21\uff09\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u7ed9\u836f\u4e00\u6b21\uff0c\u8fde\u7eed\u7ed9\u836f 4 \u6b21\u3002\u5728\u5b8c\u6210\u7b2c 4 \u6b21\u7ed9\u836f\u540e\u7684\u7b2c 8 \u5468\u548c\u7b2c 12 \u5468\u6839\u636e\u5149\u5b66\u76f8\u5e72\u65ad\u5c42\u626b\u63cf\uff08OCT\uff09\u548c\u89c6\u529b\u7ed3\u679c\u8fdb\u884c\u75be\u75c5\u6d3b\u52a8\u5ea6\u8bc4\u4f30\uff0c\u4ee5\u786e\u5b9a\u6309\u7167\u4ee5\u4e0b\u4e09\u79cd\u7ed9\u836f\u65b9\u6848\u4e4b\u4e00\u7ee7\u7eed\u7ed9\u836f\uff1a1\uff09\u7b2c 28 \u548c 44 \u5468\uff08\u5373\u6bcf 16 \u5468\u7ed9\u836f\u4e00\u6b21\uff09\uff1b2\uff09\u7b2c 24\u300136 \u548c 48 \u5468\uff08\u5373\u6bcf 12 \u5468\u7ed9\u836f\u4e00\u6b21\uff09\uff1b\u6216 3\uff09\u7b2c 20\u300128\u300136 \u548c 44 \u5468\uff08\u5373\u6bcf 8 \u5468\u7ed9\u836f\u4e00\u6b21\uff09\u3002<\/p>\n
\u7ed9\u836f\u524d\u7684\u51c6\u5907<\/p>\n
1. \u5f00\u59cb\u7ed9\u836f\u524d\uff1a<\/p>\n
\u25cf \u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\uff0c\u8bf7\u4ed4\u7ec6\u9605\u8bfb\u672c\u8bf4\u660e\u4e66\u3002<\/p>\n
\u25cf \u672c\u54c1\u5305\u88c5\u76d2\u5185\u542b 1 \u652f\u897f\u6797\u74f6\u548c 1 \u652f\u8f6c\u79fb\u7528\u8fc7\u6ee4\u9488\u5934\u3002\u74f6\u5185\u836f\u6db2\u4ec5\u4f9b\u5355\u6b21\u7ed9\u836f\u3002\u8fc7\u6ee4\u9488\u5934\u4ec5\u4f9b\u4e00\u6b21\u6027\u4f7f\u7528\u3002<\/p>\n
\u25cf \u672c\u54c1\u5e94\u7f6e\u4e8e 2\u00b0C~8\u00b0C \u4e0b\u51b7\u85cf\u3002\u8bf7\u52ff\u51b7\u51bb\u3002\u8bf7\u52ff\u632f\u6447\u3002<\/p>\n
\u25cf \u7ed9\u836f\u524d\uff0c\u672c\u54c1\u5e94\u653e\u7f6e\u81f3 20\u00b0C~25\u00b0C\u3002\u672c\u54c1\u5728\u8be5\u6e29\u5ea6\u4e0b\u6700\u957f\u53ef\u653e\u7f6e 24 \u5c0f\u65f6\u3002\u836f\u74f6\u7f6e\u4e8e\u539f\u5305\u88c5\u76d2\u4e2d\u907f\u5149\u4fdd\u5b58\u3002<\/p>\n
\u25cf \u7ed9\u836f\u524d\uff0c\u5e94\u76ee\u89c6\u68c0\u67e5\u836f\u6db2\u4e2d\u662f\u5426\u5b58\u5728\u5fae\u7c92\u7269\u548c\u53d8\u8272\u3002\u672c\u54c1\u4e3a\u65e0\u8272\u81f3\u68d5\u9ec4\u8272\uff0c\u4e14\u6f84\u6e05\u81f3\u4e73\u5149\u6eb6\u6db2\u3002<\/p>\n
\u5982\u6709\u53ef\u89c1\u5fae\u7c92\u7269\u3001\u6d51\u6d4a\u6216\u53d8\u8272\uff0c\u5207\u52ff\u4f7f\u7528\u3002<\/p>\n
\u5982\u679c\u5305\u88c5\u3001\u836f\u74f6\u548c\/\u6216\u8f6c\u79fb\u7528\u8fc7\u6ee4\u9488\u5934\u8fc7\u671f\u3001\u635f\u574f\u6216\u906d\u7a83\u542f\uff0c\u5207\u52ff\u4f7f\u7528\uff08\u89c1\u56fe A\uff09\u3002<\/p>\n
\u25cf \u6ce8\u5c04\u524d\u7684\u51c6\u5907\u5de5\u4f5c\u5e94\u5728\u65e0\u83cc\u6761\u4ef6\u4e0b\u8fdb\u884c\u3002<\/p>\n<\/p>\n
2. \u51c6\u5907\u4ee5\u4e0b\u7528\u54c1\uff1a<\/p>\n
\u25cf 1 \u74f6\u836f\u6db2\uff08\u5305\u88c5\u76d2\u5185\u9644\uff09<\/p>\n
\u25cf 1 \u652f\u65e0\u83cc 5 \u03bcm \u949d\u5934\u8f6c\u79fb\u7528\u8fc7\u6ee4\u9488\u5934\uff0818G\u00d71.5 \u82f1\u5bf8\uff09\uff08\u5305\u88c5\u76d2\u5185\u9644\uff09<\/p>\n
\u25cf 1 \u652f\u65e0\u83cc 1 ml \u9c81\u5c14\u9501\u6ce8\u5c04\u5668\uff0c\u523b\u5ea6\u4e3a 0.05 ml\uff08\u81ea\u5907\uff09<\/p>\n
\u25cf 1 \u652f\u65e0\u83cc\u6ce8\u5c04\u9488\u5934\uff0830G\u00d70.5 \u82f1\u5bf8\uff09\uff08\u81ea\u5907\uff09<\/p>\n
\u6ce8\uff1a\u5efa\u8bae\u4f7f\u7528 30G \u6ce8\u5c04\u9488\u5934\uff0c\u9488\u7ba1\u76f4\u5f84\u8fc7\u5c0f\u4f1a\u5bfc\u81f4\u6ce8\u5c04\u65f6\u963b\u529b\u8fc7\u5927<\/p>\n
\u25cf \u9152\u7cbe\u68c9\u7b7e\uff08\u81ea\u5907\uff09<\/p>\n
3. \u4ece\u5305\u88c5\u76d2\u4e2d\u53d6\u51fa\u836f\u74f6\uff0c\u6b63\u7f6e\u4e8e\u5e73\u5766\u7684\u53f0\u9762\u4e0a\uff08\u9759\u7f6e\u5927\u7ea6 1 \u5206\u949f\uff09\uff0c\u5f85\u74f6\u5185\u7684\u836f\u6db2\u6d41\u56de\u74f6\u5e95\uff08\u89c1\u56fe B\uff09\u3002\u624b\u6307\u8f7b\u5f39\u5c0f\u74f6\uff08\u89c1\u56fe C\uff09\uff0c\u4f7f\u7c98\u9644\u5728\u74f6\u9876\u7684\u836f\u6db2\u6d41\u56de\u74f6\u5e95\u3002<\/p>\n<\/p>\n
4. \u53d6\u4e0b\u7ffb\u76d6\uff08\u89c1\u56fe D\uff09\uff0c\u4f7f\u7528\u9152\u7cbe\u68c9\u7b7e\u64e6\u62ed\u836f\u74f6\u80f6\u585e\uff08\u89c1\u56fe E\uff09\u3002<\/p>\n<\/p>\n
5. \u91c7\u7528\u65e0\u83cc\u64cd\u4f5c\u6280\u672f\u5c06\u6ce8\u5c04\u5305\u4e2d\u7684 18G\u00d71.5 \u82f1\u5bf8\u8f6c\u79fb\u7528\u8fc7\u6ee4\u9488\u5934\u7262\u56fa\u8fde\u63a5\u81f3 1 ml\u9c81\u5c14\u9501\u6ce8\u5c04\u5668\u4e0a\uff08\u89c1\u56fe F\uff09\u3002<\/p>\n<\/p>\n
6. \u91c7\u7528\u65e0\u83cc\u64cd\u4f5c\u6280\u672f\uff0c\u4ece\u836f\u74f6\u80f6\u585e\u4e2d\u5fc3\u523a\u5165\u8f6c\u79fb\u7528\u8fc7\u6ee4\u9488\u5934\uff08\u89c1\u56fe G\uff09\uff0c\u5f53\u9488\u5934\u5b8c\u5168\u523a\u5165\u80f6\u585e\u540e\uff0c\u7565\u5fae\u503e\u659c\u74f6\u8eab\uff0c\u4f7f\u9488\u5934\u63a5\u89e6\u74f6\u5e95\u8fb9\u7f18\uff08\u89c1\u56fe H\uff09\u3002<\/p>\n<\/p>\n
7. \u4fdd\u6301\u74f6\u8eab\u503e\u659c\uff0c\u7f13\u6162\u62bd\u53d6\u74f6\u5185\u7684\u6240\u6709\u836f\u6db2\uff08\u89c1\u56fe I\uff09\u3002\u786e\u4fdd\u8f6c\u79fb\u7528\u8fc7\u6ee4\u9488\u5934\u7684\u659c\u9762\u5b8c\u5168\u6d78\u6ca1\u5728\u836f\u6db2\u4e2d\uff0c\u907f\u514d\u5438\u5165\u7a7a\u6c14\u3002<\/p>\n<\/p>\n
8. \u62bd\u53d6\u836f\u6db2\u8fc7\u7a0b\u4e2d\uff0c\u5145\u5206\u56de\u62bd\u82af\u6746\uff0c\u4ee5\u4fbf\u5b8c\u5168\u6392\u7a7a\u8f6c\u79fb\u7528\u8fc7\u6ee4\u9488\u5934\uff08\u89c1\u56fe I\uff09\u3002<\/p>\n
9. \u4ece\u6ce8\u5c04\u5668\u4e0a\u53d6\u4e0b\u8f6c\u79fb\u7528\u8fc7\u6ee4\u9488\u5934\uff0c\u5e76\u6309\u7167\u5f53\u5730\u6cd5\u89c4\u4e88\u4ee5\u5904\u7406\u3002<\/p>\n
\u5207\u52ff\u4f7f\u7528\u8f6c\u79fb\u7528\u8fc7\u6ee4\u9488\u5934\u8fdb\u884c\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u3002<\/p>\n
10. \u91c7\u7528\u65e0\u83cc\u64cd\u4f5c\u6280\u672f\u5c06 30G\u00d70.5 \u82f1\u5bf8\u6ce8\u5c04\u9488\u5934\u7262\u56fa\u8fde\u63a5\u81f3\u9c81\u5c14\u9501\u6ce8\u5c04\u5668\u4e0a\uff08\u89c1\u56feJ\uff09\u3002<\/p>\n<\/p>\n
11. \u5c0f\u5fc3\u5730\u62d4\u4e0b\u5851\u6599\u9488\u7ba1\u4fdd\u62a4\u5e3d\u3002<\/p>\n
12. \u624b\u6301\u6ce8\u5c04\u5668\uff0c\u6ce8\u5c04\u9488\u5934\u671d\u4e0a\uff0c\u68c0\u67e5\u6ce8\u5c04\u5668\u5185\u662f\u5426\u5b58\u5728\u6c14\u6ce1\u3002\u5982\u6709\u6c14\u6ce1\uff0c\u7528\u624b\u6307\u8f7b\u8f7b\u6572\u51fb\u6ce8\u5c04\u5668\uff0c\u76f4\u81f3\u6c14\u6ce1\u4e0a\u5347\u81f3\u9876\u90e8\uff08\u89c1\u56fe K\uff09\u3002<\/p>\n<\/p>\n
13. \u5c0f\u5fc3\u6392\u51fa\u6ce8\u5c04\u5668\u548c\u6ce8\u5c04\u9488\u5934\u4e2d\u7684\u7a7a\u6c14\uff0c\u5e76\u7f13\u6162\u63a8\u52a8\u82af\u6746\uff0c\u76f4\u81f3\u6ce8\u5c04\u5668\u6d3b\u585e\u9876\u90e8\u4e0e 0.05 ml \u523b\u5ea6\u7ebf\u5bf9\u9f50\u3002\u6ce8\u5c04\u524d\u51c6\u5907\u5de5\u4f5c\u5b8c\u6210\uff08\u89c1\u56fe L\uff09\u3002\u51c6\u5907\u5c31\u7eea\u540e\u5373\u523b\u6ce8\u5c04\u3002<\/p>\n<\/p>\n
\u6ce8\u5c04\u64cd\u4f5c<\/p>\n
\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u64cd\u4f5c\u5fc5\u987b\u5728\u65e0\u83cc\u6761\u4ef6\u4e0b\u8fdb\u884c\uff0c\u5305\u62ec\u91c7\u7528\u5916\u79d1\u624b\u672f\u7684\u624b\u90e8\u6d88\u6bd2\u3001\u4f69\u6234\u65e0\u83cc\u624b\u5957\u4ee5\u53ca\u4f7f\u7528\u65e0\u83cc\u624b\u672f\u5355\u3001\u65e0\u83cc\u5f00\u7751\u5668\uff08\u6216\u7c7b\u4f3c\u5668\u5177\uff09\u548c\u65e0\u83cc\u7a7f\u523a\u8bbe\u5907\uff08\u5982\u9700\u8981\uff09\u3002\u6ce8\u5c04\u524d\u5e94\u5bf9\u60a3\u8005\u8fdb\u884c\u5145\u5206\u9ebb\u9189\u548c\u773c\u5c40\u90e8\u7528\u5e7f\u8c31\u6297\u751f\u7d20\u3002<\/p>\n
\u7f13\u6162\u63a8\u52a8\u82af\u6746\uff0c\u76f4\u81f3\u6d3b\u585e\u5230\u8fbe\u6ce8\u5c04\u5668\u672b\u7aef\uff0c\u786e\u4fdd\u51c6\u786e\u9012\u9001 0.05 ml \u836f\u91cf\u3002\u68c0\u67e5\u80f6\u585e\u662f\u5426\u5df2\u5230\u8fbe\u6ce8\u5c04\u5668\u5e95\u90e8\uff0c\u4ee5\u786e\u8ba4\u662f\u5426\u9012\u9001\u5b8c\u6574\u5242\u91cf\u3002<\/p>\n
\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u540e\u5373\u523b\u76d1\u6d4b\u60a3\u8005\u662f\u5426\u51fa\u73b0\u773c\u5185\u538b\uff08IOP\uff09\u5347\u9ad8\u3002\u53ef\u901a\u8fc7\u68c0\u67e5\u89c6\u4e73\u5934\u704c\u6ce8\u538b\u6216\u6d4b\u5b9a\u773c\u538b\u7684\u65b9\u5f0f\u4e88\u4ee5\u76d1\u6d4b\u3002\u5fc5\u8981\u65f6\u5e94\u5907\u6709\u65e0\u83cc\u7a7f\u523a\u9488\u3002\u6ce8\u5c04\u5b8c\u6bd5\u540e\uff0c\u5e94\u6307\u5bfc\u60a3\u8005\u7acb\u5373\u62a5\u544a\u63d0\u793a\u773c\u5185\u708e\u6216\u89c6\u7f51\u819c\u8131\u79bb\u7684\u4efb\u4f55\u75c7\u72b6\uff08\u4f8b\u5982\u89c6\u89c9\u4e27\u5931\u3001\u773c\u75db\u3001\u773c\u775b\u53d1\u7ea2\u3001\u754f\u5149\u3001\u89c6\u7269\u6a21\u7cca\uff09\u3002\u6bcf\u652f\u6ce8\u5c04\u5668\u5e94\u4ec5\u7528\u4e8e\u5355\u4fa7\u773c\u6cbb\u7597\u3002\u5982\u679c\u5bf9\u4fa7\u773c\u9700\u8981\u6cbb\u7597\uff0c\u5e94\u53e6\u53d6\u4e00\u74f6\u5168\u65b0\u7684\u6ce8\u5c04\u6eb6\u6db2\uff0c\u5e76\u66f4\u6362\u65e0\u83cc\u533a\u3001\u6ce8\u5c04\u5668\u3001\u624b\u5957\u3001\u624b\u672f\u5355\u3001\u5f00\u7751\u5668\u3001\u8fc7\u6ee4\u9488\u5934\u548c\u6ce8\u5c04\u9488\u5934\u3002<\/p>\n
\u914d\u4f0d\u7981\u5fcc<\/p>\n
\u5c1a\u672a\u8fdb\u884c\u76f8\u5bb9\u6027\u7814\u7a76\uff0c\u56e0\u6b64\u672c\u54c1\u4e0d\u5f97\u4e0e\u5176\u4ed6\u836f\u54c1\u6df7\u5408\u4f7f\u7528\u3002<\/p>\n
\u672a\u4f7f\u7528\/\u8fc7\u671f\u836f\u7269\u7684\u5904\u7f6e<\/p>\n
\u5e94\u5c3d\u91cf\u51cf\u5c11\u5c06\u836f\u7269\u6392\u653e\u5230\u73af\u5883\u4e2d\u3002\u4e0d\u5e94\u901a\u8fc7\u6c61\u6c34\u5904\u7f6e\u672c\u54c1\uff0c\u540c\u65f6\u907f\u514d\u6309\u751f\u6d3b\u5783\u573e\u5904\u7f6e\u672c\u54c1\u3002<\/p>\n
\u5173\u4e8e\u6ce8\u5c04\u5668\u548c\u5176\u4ed6\u836f\u7528\u9510\u5668\u7684\u4f7f\u7528\u548c\u5904\u7f6e\uff0c\u5e94\u4e25\u683c\u9075\u5b88\u4ee5\u4e0b\u89c4\u5b9a\uff1a<\/p>\n
\u25cf\u9488\u5934\u548c\u6ce8\u5c04\u5668\u7edd\u5bf9\u4e0d\u53ef\u91cd\u590d\u4f7f\u7528\u3002<\/p>\n
\u25cf\u5c06\u6240\u6709\u4f7f\u7528\u8fc7\u7684\u9488\u5934\u548c\u6ce8\u5c04\u5668\u653e\u5165\u9510\u5668\u76d2\uff08\u9632\u7a7f\u523a\u4e00\u6b21\u6027\u5bb9\u5668\uff09\u4e2d\u3002<\/p>\n
\u4efb\u4f55\u672a\u4f7f\u7528\u7684\u836f\u54c1\u6216\u5e9f\u5f03\u7269\u5747\u5e94\u6309\u7167\u5f53\u5730\u8981\u6c42\u8fdb\u884c\u5904\u7f6e\u3002<\/p>\n
\u5ef6\u8fdf\u6216\u9519\u8fc7\u7ed9\u836f<\/p>\n
\u5982\u679c\u5ef6\u8fdf\u6216\u9519\u8fc7\u7ed9\u836f\uff0c\u60a3\u8005\u5e94\u5728\u4e0b\u6b21\u5c31\u8bca\u65f6\u8fd4\u9662\u63a5\u53d7\u533b\u751f\u8bc4\u4f30\uff0c\u5e76\u6839\u636e\u533b\u751f\u7684\u5224\u65ad\u51b3\u5b9a\u662f\u5426\u7ee7\u7eed\u7ed9\u836f\u3002<\/p>\n
\u5982\u679c\u89c6\u529b\u548c\/\u6216\u89e3\u5256\u5b66\u7ed3\u679c\u8868\u660e\u60a3\u8005\u65e0\u6cd5\u4ece\u7ee7\u7eed\u6cbb\u7597\u4e2d\u83b7\u76ca\uff0c\u5219\u5e94\u505c\u7528\u672c\u54c1\u3002<\/p>\n
\u5242\u91cf\u8c03\u6574<\/p>\n
\u4e0d\u5efa\u8bae\u5bf9\u672c\u54c1\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<\/p>\n
\u7279\u6b8a\u4eba\u7fa4\u7528\u836f<\/p>\n
\u513f\u7ae5\u7528\u836f<\/p>\n
\u5c1a\u672a\u786e\u7acb\u672c\u54c1\u5728\u513f\u7ae5\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n
\u8001\u5e74\u7528\u836f<\/p>\n
\u226565 \u5c81\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff08\u89c1\u3010\u8001\u5e74\u7528\u836f\u3011\u548c\u3010\u4e34\u5e8a\u836f\u7406\u3011\u8001\u5e74\u4eba\u7fa4\uff09\u3002<\/p>\n
\u80be\u529f\u80fd\u4e0d\u5168<\/p>\n
\u5c1a\u672a\u5728\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u4e2d\u9488\u5bf9\u6cd5\u745e\u897f\u5355\u6297\u5f00\u5c55\u4efb\u4f55\u7279\u5b9a\u7814\u7a76\u3002\u5bf9\u6240\u6709\u4e34\u5e8a\u7814\u7a76\uff08\u5176\u4e2d 64%\u7684\u60a3\u8005\u6709\u80be\u529f\u80fd\u635f\u5bb3[\u8f7b\u5ea638%\u3001\u4e2d\u5ea624%\u548c\u91cd\u5ea62%]\uff09\u4e2d\u7684\u60a3\u8005\u8fdb\u884c\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\u663e\u793a\uff0c\u6cd5\u745e\u897f\u5355\u6297\u73bb\u7483\u4f53\u5185\u7ed9\u836f\u540e\u5168\u8eab\u836f\u4ee3\u52a8\u529b\u5b66\u65e0\u5dee\u5f02\u3002\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u65e0\u9700\u8c03\u6574\u672c\u54c1\u7684\u5242\u91cf\u3002<\/p>\n
\u809d\u529f\u80fd\u4e0d\u5168<\/p>\n
\u5c1a\u672a\u5728\u809d\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u4e2d\u9488\u5bf9\u6cd5\u745e\u897f\u5355\u6297\u5f00\u5c55\u4efb\u4f55\u7279\u5b9a\u7814\u7a76\u3002\u4f46\u662f\uff0c\u8be5\u4eba\u7fa4\u7528\u836f\u65e0\u9700\u7279\u6b8a\u8003\u8651\uff0c\u56e0\u4e3a\u6cd5\u745e\u897f\u5355\u6297\u901a\u8fc7\u86cb\u767d\u6c34\u89e3\u8fdb\u884c\u4ee3\u8c22\uff0c\u4e0d\u4f9d\u8d56\u4e8e\u809d\u529f\u80fd\u3002\u809d\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<\/p>\n
\u5176\u4ed6\u7279\u6b8a\u60a3\u8005\u4eba\u7fa4<\/p>\n
\u4efb\u4f55\u7814\u7a76\u4eba\u7fa4\uff08\u5982\u6027\u522b\u3001\u4eba\u79cd\uff09\u5747\u65e0\u9700\u8fdb\u884c\u7279\u6b8a\u7684\u5242\u91cf\u8c03\u6574\u3002<\/p>\n
\u3010\u4e0d\u826f\u53cd\u5e94\u3011\u4e34\u5e8a\u8bd5\u9a8c\u5b89\u5168\u6027\u7279\u5f81\u603b\u7ed3<\/p>\n
\u5728\u9002\u5e94\u75c7\u4e3a DME \u548c nAMD \u7684 4 \u9879 III \u671f\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u6700\u5e38\u62a5\u544a\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u767d\u5185\u969c\uff0813%\uff09\u3001\u7ed3\u819c\u51fa\u8840\uff088%\uff09\u3001\u73bb\u7483\u4f53\u8131\u79bb\uff085%\uff09\u3001IOP \u5347\u9ad8\uff084%\uff09\u3001\u73bb\u7483\u4f53\u98de\u868a\u75c7\uff084%\uff09\u3001\u773c\u75db\uff083%\uff09\u548c\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u6495\u88c2\uff08\u4ec5 nAMD\uff09\uff083%\uff09\u3002<\/p>\n
\u6700\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u8461\u8404\u819c\u708e\uff080.6%\uff09\u3001\u611f\u67d3\u6027\u773c\u5185\u708e\uff080.5%\uff09\u3001\u73bb\u7483\u4f53\u708e\uff080.3%\uff09\u3001\u89c6\u7f51\u819c\u6495\u88c2\uff080.2%\uff09\u3001\u5b54\u6e90\u6027\u89c6\u7f51\u819c\u8131\u79bb\uff080.1%\uff09\u548c\u5916\u4f24\u6027\u767d\u5185\u969c\uff08<0.1%\uff09\u3002<\/p>\n
\u4e2d\u56fd\u53c2\u4e0e DME \u548c nAMD \u4e34\u5e8a\u8bd5\u9a8c\u7684\u60a3\u8005\u7684\u5b89\u5168\u6027\u6570\u636e\u663e\u793a\u4e2d\u56fd\u4eba\u7fa4\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5168\u7403\u4eba\u7fa4\u4e00\u81f4\u3002<\/p>\n
\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u6c47\u603b\u8868<\/p>\n
\u4e0b\u8ff0\u5b89\u5168\u6027\u6570\u636e\u5305\u62ec\u9002\u5e94\u75c7\u4e3a DME \u548c nAMD \u7684 4 \u9879 III \u671f\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u7684\u6c47\u603b\u6570\u636e\u4e2d\u6240\u6709\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n
\u6839\u636eMedDRA\u7cfb\u7edf\u5668\u5b98\u5206\u7c7b\u5217\u51fa\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u4f7f\u7528\u4ee5\u4e0b\u60ef\u4f8b\u6309\u53d1\u751f\u7387\u8fdb\u884c\u6392\u5e8f\uff1a\u975e\u5e38\u5e38\u89c1\uff08\u22651\/10\uff09\u3001\u5e38\u89c1\uff08\u22651\/100\u81f3<1\/10\uff09\u3001\u5076\u89c1\uff08\u22651\/1000\u81f3<1\/100\uff09\u3001\u7f55\u89c1\uff08\u22651\/10000\u81f3<1\/1000\uff09\u3002<\/p>\n
\u8868 1\uff1aIII \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u6cd5\u745e\u897f\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94\u603b\u7ed3<\/p>\n<\/p>\n
\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u9009\u5b9a\u7684\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u63cf\u8ff0<\/p>\n
\u52a8\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6<\/p>\n
VEGF \u6291\u5236\u5242\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u540e\uff0c\u7406\u8bba\u4e0a\u5b58\u5728\u52a8\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6\uff08ATE\uff09\u7684\u98ce\u9669\uff0c\u5305\u62ec\u5352\u4e2d\u548c\u5fc3\u808c\u6897\u6b7b\u3002\u5728DME\u548cnAMD\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u6cd5\u745e\u897f\u5355\u6297\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u52a8\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6\u7684\u53d1\u751f\u7387\u4f4e\u3002\u5728\u5404\u9002\u5e94\u75c7\u4e2d\uff0c\u672a\u89c2\u5bdf\u5230\u6cd5\u745e\u897f\u5355\u6297\u6cbb\u7597\u7ec4\u4e0e\u5bf9\u7167\u836f\u7269\u7ec4\u4e4b\u95f4\u5b58\u5728\u660e\u663e\u5dee\u5f02\u3002<\/p>\n
\u5728 DME \u60a3\u8005\u5f00\u5c55\u7684\u7814\u7a76\u4e2d\uff0c\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4ece\u57fa\u7ebf\u81f3\u7b2c100\u5468\u7684 ATE \u53d1\u751f\u7387\u4e3a5%\uff0864\/1262\uff09\uff0c\u4e0e\u63a5\u53d7\u963f\u67cf\u897f\u666e\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u5f53\uff085%\uff0c32\/625\uff09\u3002<\/p>\n
\u5728 nAMD \u60a3\u8005\u5f00\u5c55\u7684\u7814\u7a76\u4e2d\uff0c\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u7b2c1\u5e74\u7684 ATE \u53d1\u751f\u7387\u4e3a1%\uff087\/664\uff09\uff0c\u4e0e\u63a5\u53d7\u963f\u67cf\u897f\u666e\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u5f53\uff081%\uff0c6\/662\uff09\u3002<\/p>\n
\u4e0a\u5e02\u540e\u7ecf\u9a8c<\/p>\n
\u5728\u4e0a\u5e02\u540e\u81ea\u53d1\u62a5\u544a\u4e2d\u53d1\u73b0\u4e86\u7f55\u89c1\u7684\u89c6\u7f51\u819c\u8840\u7ba1\u708e\u548c\/\u6216\u89c6\u7f51\u819c\u95ed\u585e\u6027\u8840\u7ba1\u708e\u75c5\u4f8b\u3002\u5728\u63a5\u53d7\u5176\u4ed6 IVT \u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u4e5f\u6709\u89c6\u7f51\u819c\u8840\u7ba1\u708e\u548c\u89c6\u7f51\u819c\u95ed\u585e\u6027\u8840\u7ba1\u708e\u62a5\u9053\u3002<\/p>\n
\u773c\u90e8\u75be\u75c5\uff1a\u89c6\u7f51\u819c\u8840\u7ba1\u708e\u3001\u89c6\u7f51\u819c\u95ed\u585e\u6027\u8840\u7ba1\u708e<\/p>\n
\u514d\u75ab\u539f\u6027<\/p>\n
\u91c7\u96c6\u60a3\u8005\u7684\u8840\u6d46\u6837\u54c1\u8bc4\u4f30\u672c\u54c1\u7684\u514d\u75ab\u539f\u6027\u3002\u514d\u75ab\u539f\u6027\u6570\u636e\u53cd\u6620\u4e86\u514d\u75ab\u6d4b\u5b9a\u4e2d\u6297\u6cd5\u745e\u897f\u5355\u6297\u6297\u4f53\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\u7684\u60a3\u8005\u767e\u5206\u6bd4\u3002\u514d\u75ab\u5e94\u7b54\u7684\u68c0\u6d4b\u9ad8\u5ea6\u4f9d\u8d56\u4e8e\u6240\u7528\u8bd5\u9a8c\u65b9\u6cd5\u7684\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u3001\u6837\u54c1\u5904\u7406\u3001\u6837\u54c1\u91c7\u96c6\u65f6\u95f4\u3001\u5408\u5e76\u7528\u836f\u4ee5\u53ca\u57fa\u7840\u75be\u75c5\u3002\u56e0\u6b64\uff0c\u76f4\u63a5\u6bd4\u8f83\u6297\u6cd5\u745e\u897f\u5355\u6297\u6297\u4f53\u53d1\u751f\u7387\u4e0e\u5176\u4ed6\u4ea7\u54c1\u7684\u6297\u4f53\u53d1\u751f\u7387\u53ef\u80fd\u4ea7\u751f\u8bef\u5bfc\u3002<\/p>\n
\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u80fd\u53d1\u751f\u514d\u75ab\u5e94\u7b54\u3002\u5728 DME \u548c nAMD \u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u7814\u7a76\u4e2d\uff0c\u6297\u6cd5\u745e\u897f\u5355\u6297\u6297\u4f53\u7684\u6cbb\u7597\u524d\u6297\u4f53\u9633\u6027\u7387\u5206\u522b\u7ea6\u4e3a0.8%\u548c1.8%\u3002\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u5404\u9879\u7814\u7a76\u548c\u5404\u6cbb\u7597\u7ec4\u4e2d\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684 DME \u548c nAMD \u60a3\u8005\u4e2d\u6297\u6cd5\u745e\u897f\u5355\u6297\u6297\u4f53\u7684\u9633\u6027\u7387\u5206\u522b\u7ea6\u4e3a9.6%\u548c13.8%\u3002\u4e0e\u6240\u6709\u6cbb\u7597\u6027\u86cb\u767d\u7c7b\u4f3c\uff0c\u672c\u54c1\u53ef\u80fd\u5177\u6709\u514d\u75ab\u539f\u6027\u3002<\/p>\n
\u3010\u7981\u5fcc\u3011\u672c\u54c1\u7981\u7528\u4e8e\u6709\u773c\u90e8\u6216\u773c\u5468\u611f\u67d3\u7684\u60a3\u8005\u3002<\/p>\n
\u672c\u54c1\u7981\u7528\u4e8e\u6709\u6d3b\u52a8\u6027\u773c\u5185\u708e\u75c7\u7684\u60a3\u8005\u3002<\/p>\n
\u672c\u54c1\u7981\u7528\u4e8e\u5df2\u77e5\u5bf9\u6cd5\u745e\u897f\u5355\u6297\u6216\u4efb\u4f55\u8f85\u6599\u8fc7\u654f\u7684\u60a3\u8005\u3002\u8d85\u654f\u53cd\u5e94\u53ef\u80fd\u8868\u73b0\u4e3a\u76ae\u75b9\u3001\u7619\u75d2\u3001\u8368\u9ebb\u75b9\u3001\u7ea2\u6591\u6216\u91cd\u5ea6\u773c\u5185\u708e\u75c7\u3002<\/p>\n
\u3010\u6ce8\u610f\u4e8b\u9879\u3011\u53ef\u8ffd\u6eaf\u6027<\/p>\n
\u4e3a\u4e86\u4fdd\u6301\u751f\u7269\u5236\u54c1\u7684\u53ef\u8ffd\u6eaf\u6027\uff0c\u5e94\u6e05\u695a\u8bb0\u5f55\u6240\u4f7f\u7528\u836f\u54c1\u7684\u540d\u79f0\u548c\u6279\u53f7\u3002<\/p>\n
\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u76f8\u5173\u53cd\u5e94<\/p>\n
\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\uff08\u5305\u62ec\u6cd5\u745e\u897f\u5355\u6297\u6ce8\u5c04\uff09\u90fd\u53ef\u80fd\u5bfc\u81f4\u611f\u67d3\u6027\u773c\u5185\u708e\u3001\u773c\u5185\u708e\u75c7\u3001\u5b54\u6e90\u6027\u89c6\u7f51\u819c\u8131\u79bb\u3001\u89c6\u7f51\u819c\u6495\u88c2\u548c\u533b\u6e90\u6027\u5916\u4f24\u6027\u767d\u5185\u969c\u3002\u4f7f\u7528\u672c\u54c1\u65f6\uff0c\u5fc5\u987b\u59cb\u7ec8\u4f7f\u7528\u9002\u5f53\u7684\u65e0\u83cc\u6ce8\u5c04\u6280\u672f\u3002\u5e94\u6307\u5bfc\u60a3\u8005\u7acb\u5373\u62a5\u544a\u4efb\u4f55\u63d0\u793a\u773c\u5185\u708e\u6216\u4e0a\u8ff0\u4efb\u4f55\u4e8b\u4ef6\u7684\u75c7\u72b6\uff0c\u5982\u75bc\u75db\u3001\u89c6\u529b\u4e27\u5931\u3001\u754f\u5149\u3001\u89c6\u7269\u6a21\u7cca\u3001\u98de\u868a\u75c7\u6216\u53d1\u7ea2\uff0c\u4ee5\u4fbf\u53ca\u65f6\u8fdb\u884c\u9002\u5f53\u6cbb\u7597\u3002\u6ce8\u5c04\u9891\u7387\u589e\u52a0\u7684\u60a3\u8005\u53d1\u751f\u64cd\u4f5c\u5e76\u53d1\u75c7\u7684\u98ce\u9669\u53ef\u80fd\u589e\u52a0\u3002<\/p>\n
IOP \u5347\u9ad8<\/p>\n
\u66fe\u89c2\u5bdf\u5230\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u540e 60 \u5206\u949f\u5185\u51fa\u73b0\u4e00\u8fc7\u6027 IOP \u5347\u9ad8\uff0c\u5305\u62ec\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u672c\u54c1\u7684\u60a3\u8005\u3002\u9752\u5149\u773c\u63a7\u5236\u4e0d\u4f73\u7684\u60a3\u8005\u9700\u8981\u91c7\u53d6\u7279\u6b8a\u9884\u9632\u63aa\u65bd\uff08IOP\u226530 mmHg \u65f6\u4e0d\u5f97\u6ce8\u5c04\u672c\u54c1\uff09\u3002\u5728\u4efb\u4f55\u60c5\u51b5\u4e0b\uff0c\u90fd\u5fc5\u987b\u5bf9 IOP \u548c\u89c6\u795e\u7ecf\u4e73\u5934\u704c\u6ce8\u548c\/\u6216\u89c6\u529b\u8fdb\u884c\u9002\u5f53\u76d1\u6d4b\u548c\u7ba1\u7406\u3002<\/p>\n
\u52a8\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6<\/p>\n
\u5c3d\u7ba1\u5728\u672c\u54c1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u52a8\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6\uff08ATE\uff09\u7684\u53d1\u751f\u7387\u4f4e\uff0c\u4f46 VEGF \u6291\u5236\u5242\u73bb\u7483\u4f53\u5185\u7ed9\u836f\u540e\u5b58\u5728\u53d1\u751f ATE \u7684\u6f5c\u5728\u98ce\u9669\u3002ATE \u5b9a\u4e49\u4e3a\u975e\u81f4\u6b7b\u6027\u5352\u4e2d\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u808c\u6897\u6b7b\u6216\u8840\u7ba1\u6027\u6b7b\u4ea1\uff08\u5305\u62ec\u4e0d\u660e\u539f\u56e0\u6b7b\u4ea1\uff09\u3002<\/p>\n
\u514d\u75ab\u539f\u6027<\/p>\n
\u4e0e\u6240\u6709\u6cbb\u7597\u6027\u86cb\u767d\u76f8\u540c\uff0c\u672c\u54c1\u53ef\u80fd\u5f15\u53d1\u514d\u75ab\u5e94\u7b54\u3002\u5e94\u6307\u5bfc\u60a3\u8005\u62a5\u544a\u4efb\u4f55\u773c\u5185\u708e\u75c7\u7684\u4efb\u4f55\u4f53\u5f81\u6216\u75c7\u72b6\uff0c\u5982\u89c6\u529b\u4e27\u5931\u3001\u773c\u75db\u3001\u5bf9\u5149\u7684\u654f\u611f\u6027\u589e\u52a0\u3001\u98de\u868a\u75c7\u6216\u773c\u7ea2\u52a0\u91cd\uff0c\u8fd9\u53ef\u80fd\u662f\u8d85\u654f\u53cd\u5e94\u5f15\u8d77\u7684\u4e34\u5e8a\u4f53\u5f81\u3002<\/p>\n
\u53cc\u773c\u6cbb\u7597<\/p>\n
\u5c1a\u672a\u7814\u7a76\u672c\u54c1\u53cc\u773c\u540c\u65f6\u7ed9\u836f\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u53cc\u773c\u6cbb\u7597\u53ef\u80fd\u5f15\u8d77\u53cc\u4fa7\u773c\u90e8\u4e0d\u826f\u53cd\u5e94\u548c\/\u6216\u53ef\u80fd\u5bfc\u81f4\u5168\u8eab\u66b4\u9732\u589e\u52a0\uff0c\u7531\u6b64\u53ef\u80fd\u589e\u52a0\u5168\u8eab\u4e0d\u826f\u53cd\u5e94\u7684\u98ce\u9669\u3002\u5728\u83b7\u5f97\u53cc\u773c\u7528\u836f\u6570\u636e\u4e4b\u524d\uff0c\u8fd9\u662f\u6cd5\u745e\u897f\u5355\u6297\u7684\u7406\u8bba\u98ce\u9669\u3002<\/p>\n
\u4e0e\u5176\u4ed6\u6297 VEGF \u836f\u7269\u5408\u5e76\u7528\u836f<\/p>\n
\u5c1a\u65e0\u672c\u54c1\u4e0e\u6297 VEGF \u836f\u7269\u5728\u540c\u4fa7\u773c\u5408\u5e76\u4f7f\u7528\u7684\u6570\u636e\u3002\u6cd5\u745e\u897f\u5355\u6297\u4e0d\u5e94\u4e0e\u5176\u4ed6\u6297VEGF \u836f\u7269\uff08\u5168\u8eab\u6216\u773c\u90e8\uff09\u540c\u65f6\u7ed9\u836f\u3002<\/p>\n
\u6682\u505c\u6cbb\u7597<\/p>\n
\u4ee5\u4e0b\u60a3\u8005\u5e94\u6682\u505c\u6cbb\u7597\uff1a<\/p>\n
\u00b7 \u5b54\u6e90\u6027\u89c6\u7f51\u819c\u8131\u79bb\u30013 \u671f\u6216 4 \u671f\u9ec4\u6591\u88c2\u5b54\u3001\u89c6\u7f51\u819c\u6495\u88c2\uff1b\u5728\u5145\u5206\u4fee\u590d\u4e4b\u524d\uff0c\u4e0d\u5f97\u6062\u590d\u6cbb\u7597\u3002<\/p>\n
\u00b7 \u4e0e\u672b\u6b21\u89c6\u529b\u8bc4\u4f30\u76f8\u6bd4\uff0c\u51fa\u73b0\u6cbb\u7597\u76f8\u5173\u7684\u6700\u4f73\u77eb\u6b63\u89c6\u529b\uff08BCVA\uff09\u4e0b\u964d\u2265 30\u4e2a\u5b57\u6bcd\u6570\uff0c\u4e0d\u5f97\u5728\u4e0b\u4e00\u6b21\u8ba1\u5212\u7684\u6cbb\u7597\u4e4b\u524d\u6062\u590d\u6cbb\u7597\u3002<\/p>\n
\u00b7 \u773c\u5185\u538b\u2265 30 mmHg\u3002<\/p>\n
\u00b7 \u7d2f\u53ca\u4e2d\u5fc3\u51f9\u7684\u89c6\u7f51\u819c\u4e0b\u51fa\u8840\uff0c\u6216\u8005\u51fa\u8840\u9762\u79ef\u5360\u75c5\u53d8\u603b\u9762\u79ef\u7684 50%\u53ca\u4ee5\u4e0a\u3002<\/p>\n
\u00b7 \u5728\u5df2\u8fdb\u884c\u6216\u8ba1\u5212\u8fdb\u884c\u773c\u5185\u624b\u672f\u7684\u524d\u540e 28 \u5929\uff1b\u4e0d\u5f97\u5728\u4e0b\u4e00\u6b21\u8ba1\u5212\u7684\u6cbb\u7597\u4e4b\u524d\u6062\u590d\u6cbb\u7597\u3002<\/p>\n
\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u6495\u88c2<\/p>\n
\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\uff08RPE\uff09\u6495\u88c2\u662f nAMD \u60a3\u8005\u8272\u7d20\u4e0a\u76ae\u8131\u79bb\uff08PED\uff09\u7684\u4e00\u79cd\u5e76\u53d1\u75c7\u3002\u4f7f\u7528\u6297 VEGF \u836f\u7269\u6cbb\u7597 nAMD \u540e\u53d1\u751f RPE \u6495\u88c2\u7684\u76f8\u5173\u98ce\u9669\u56e0\u7d20\u5305\u62ec\u5927\u9762\u79ef\u7684\u548c\/\u6216\u9ad8\u5ea6\u9686\u8d77\u7684 PED\u3002\u5177\u6709 RPE \u6495\u88c2\u7684\u8fd9\u4e9b\u98ce\u9669\u56e0\u7d20\u7684\u60a3\u8005\u5e94\u614e\u7528\u672c\u54c1\u3002RPE \u6495\u88c2\u5728\u63a5\u53d7 IVT \u6297 VEGF \u836f\u7269\uff08\u5305\u62ec\u6cd5\u745e\u897f\u5355\u6297\uff09\u6cbb\u7597\u7684\u4f34 PED \u7684 nAMD \u60a3\u8005\u4e2d\u5f88\u5e38\u89c1\u3002\u6cd5\u745e\u897f\u5355\u6297\u6cbb\u7597\u7ec4\u7684 RPE \u6495\u88c2\u53d1\u751f\u7387\uff082.9%\uff09\u9ad8\u4e8e\u963f\u67cf\u897f\u666e\u6cbb\u7597\u7ec4\uff081.5%\uff09\u3002\u5927\u591a\u6570\u4e8b\u4ef6\u53d1\u751f\u5728\u8d1f\u8377\u5242\u91cf\u671f\uff0c\u4e25\u91cd\u7a0b\u5ea6\u4e3a\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\uff0c\u5bf9\u89c6\u529b\u65e0\u5f71\u54cd\u3002<\/p>\n
\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u6709\u9650\u7684\u60a3\u8005<\/p>\n
\u226585\u5c81\u7684nAMD\u60a3\u8005\uff0cDME\u4f34I\u578b\u7cd6\u5c3f\u75c5\u7684\u60a3\u8005\u3001\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff08HbA1c\uff09\u8d85\u8fc710%\u7684\u60a3\u8005\u3001\u9ad8\u5371\u589e\u6b96\u671f\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\uff08DR\uff09\u3001\u9ad8\u8840\u538b\uff08\u2265 140\/90 mmHg\uff09\u548c\u8840\u7ba1\u75be\u75c5\u60a3\u8005\u3001\u6301\u7eed\u7ed9\u836f\u95f4\u9694\u77ed\u4e8e Q8W \u7684\u60a3\u8005\u6216\u4f34\u6d3b\u52a8\u6027\u5168\u8eab\u611f\u67d3\u7684 nAMD \u548cDME \u60a3\u8005\u7684\u6cbb\u7597\u7ecf\u9a8c\u6709\u9650\u3002\u5173\u4e8e\u6301\u7eed\u7ed9\u836f\u95f4\u9694\u77ed\u4e8e 8 \u5468\u60a3\u8005\u7684\u5b89\u5168\u6027\u4fe1\u606f\u6709\u9650\uff0c\u6b64\u7c7b\u95f4\u9694\u53ef\u80fd\u4e0e\u773c\u90e8\u548c\u5168\u8eab\u4e0d\u826f\u53cd\u5e94\uff08\u5305\u62ec\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff09\u7684\u98ce\u9669\u8f83\u9ad8\u76f8\u5173\u3002\u5c1a\u65e0\u6cd5\u745e\u897f\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u4f34\u672a\u53d7\u63a7\u5236\u7684\u9ad8\u8840\u538b\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u7ecf\u9a8c\u3002\u533b\u751f\u5728\u6cbb\u7597\u6b64\u7c7b\u60a3\u8005\u65f6\u5e94\u8003\u8651\u5230\u8be5\u4fe1\u606f\u7f3a\u4e4f\u3002<\/p>\n
\u5bf9\u9a7e\u9a76\u548c\u64cd\u4f5c\u673a\u68b0\u80fd\u529b\u7684\u5f71\u54cd<\/p>\n
\u7531\u4e8e\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u548c\u76f8\u5173\u773c\u90e8\u68c0\u67e5\u540e\u53ef\u80fd\u51fa\u73b0\u6682\u65f6\u6027\u89c6\u89c9\u969c\u788d\uff0c\u6240\u4ee5\u6ce8\u5c04\u672c\u54c1\u53ef\u80fd\u5bf9\u9a7e\u9a76\u548c\u64cd\u4f5c\u673a\u68b0\u7684\u80fd\u529b\u4ea7\u751f\u8f7b\u5fae\u5f71\u54cd\u3002\u5728\u89c6\u89c9\u529f\u80fd\u5145\u5206\u6062\u590d\u4e4b\u524d\uff0c\u60a3\u8005\u4e0d\u5f97\u9a7e\u9a76\u6216\u64cd\u4f5c\u673a\u68b0\u3002<\/p>\n
\u3010\u5b55\u5987\u53ca\u54fa\u4e73\u671f\u5987\u5973\u7528\u836f\u3011\u6709\u751f\u80b2\u529b\u7684\u5987\u5973<\/p>\n
\u751f\u80b2\u529b<\/p>\n
\u5c1a\u672a\u5f00\u5c55\u672c\u54c1\u5bf9\u4eba\u7c7b\u751f\u80b2\u529b\u5f71\u54cd\u7684\u7814\u7a76\uff0c\u5c1a\u4e0d\u6e05\u695a\u672c\u54c1\u662f\u5426\u4f1a\u5f71\u54cd\u751f\u6b96\u80fd\u529b\u3002\u6839\u636e\u5176\u4f5c\u7528\u673a\u5236\u63a8\u6d4b\uff0c\u672c\u54c1\u53ef\u80fd\u5bf9\u751f\u6b96\u80fd\u529b\u6784\u6210\u98ce\u9669\u3002<\/p>\n
\u907f\u5b55<\/p>\n
\u6709\u751f\u80b2\u529b\u7684\u5973\u6027\u5e94\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u548c\u672c\u54c1\u672b\u6b21\u4f7f\u7528\u540e\u81f3\u5c11 3 \u4e2a\u6708\u5185\u91c7\u53d6\u907f\u5b55\u63aa\u65bd\u3002<\/p>\n
\u598a\u5a20<\/p>\n
\u98ce\u9669\u6982\u8ff0<\/p>\n
\u5c1a\u672a\u5728\u598a\u5a20\u5973\u6027\u4e2d\u5f00\u5c55\u5145\u5206\u4e14\u826f\u597d\u5bf9\u7167\u7684\u7814\u7a76\u8003\u5bdf\u672c\u54c1\u3002<\/p>\n
\u598a\u5a20\u7334\u5728\u6574\u4e2a\u5668\u5b98\u5f62\u6210\u671f\u95f4\u9759\u8109\uff08IV\uff09\u63a5\u53d7\u672c\u54c1\uff0c\u5242\u91cf\u76f8\u5f53\u4e8e\u4eba\u4f53\u6700\u5927\u63a8\u8350\u5242\u91cf\u4e0b\u66b4\u9732\u91cf\u6c34\u5e73\uff08\u57fa\u4e8e Cmax\u8ba1\u7b97\uff09\u7684 158 \u500d\uff0c\u89c2\u5bdf\u5230\u6d41\u4ea7\u53d1\u751f\u7387\u589e\u52a0\uff08\u89c1\u3010\u836f\u7406\u6bd2\u7406\u3011\u751f\u6b96\u6bd2\u6027\uff09\u3002\u6839\u636e VEGF \u548c Ang-2 \u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236\u63a8\u6d4b\uff0c\u672c\u54c1\u53ef\u80fd\u5bf9\u5973\u6027\u751f\u6b96\u80fd\u529b\u548c\u80da\u80ce-\u80ce\u513f\u53d1\u80b2\u6784\u6210\u98ce\u9669\u3002\u598a\u5a20\u671f\u95f4\u4e0d\u5b9c\u4f7f\u7528\u672c\u54c1\uff0c\u9664\u975e\u60a3\u8005\u7684\u6f5c\u5728\u83b7\u76ca\u8d85\u8fc7\u80ce\u513f\u9762\u4e34\u7684\u6f5c\u5728\u98ce\u9669\u3002<\/p>\n
\u54fa\u4e73<\/p>\n
\u98ce\u9669\u6982\u8ff0<\/p>\n
\u5c1a\u65e0\u5173\u4e8e\u6cd5\u745e\u897f\u5355\u6297\u662f\u5426\u5206\u6ccc\u81f3\u4eba\u4e73\u6c41\u3001\u836f\u7269\u5bf9\u6bcd\u4e73\u5582\u517b\u7684\u5a74\u513f\u7684\u5f71\u54cd\u6216\u836f\u7269\u5bf9\u4e73\u6c41\u751f\u6210\u7684\u5f71\u54cd\u7684\u4fe1\u606f\u3002\u8bb8\u591a\u836f\u7269\u53ef\u5206\u6ccc\u81f3\u4eba\u4e73\u6c41\u4e2d\uff0c\u53ef\u80fd\u88ab\u6bcd\u4e73\u5582\u517b\u7684\u5a74\u513f\u5438\u6536\u5e76\u4ea7\u751f\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n
\u5e94\u8003\u8651\u6bcd\u4e73\u5582\u517b\u5bf9\u5a74\u513f\u53d1\u80b2\u548c\u5065\u5eb7\u7684\u76ca\u5904\u4ee5\u53ca\u6bcd\u4eb2\u5bf9\u672c\u54c1\u7684\u4e34\u5e8a\u9700\u6c42\u548c\u672c\u54c1\u5bf9\u6bcd\u4e73\u5582\u517b\u5a74\u513f\u7684\u4efb\u4f55\u6f5c\u5728\u4e0d\u826f\u5f71\u54cd\u3002<\/p>\n
\u3010\u513f\u7ae5\u7528\u836f\u3011\u5c1a\u672a\u786e\u7acb\u672c\u54c1\u5728\u513f\u7ae5\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n
\u3010\u8001\u5e74\u7528\u836f\u3011\u57284\u9879III\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u968f\u673a\u5206\u914d\u81f3\u6cd5\u745e\u897f\u5355\u6297\u6cbb\u7597\u7ec4\u7684\u60a3\u8005\u4e2d\u7ea660%\uff081149\/1929\uff09\u7684\u60a3\u8005\u226565 \u5c81\u3002\u5728\u8fd9\u4e9b\u7814\u7a76\u4e2d\uff0c\u672a\u89c2\u5bdf\u5230\u672c\u54c1\u7684\u6709\u6548\u6027\u6216\u5b89\u5168\u6027\u968f\u5e74\u9f84\u589e\u957f\u800c\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002\u226565 \u5c81\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff08\u89c1\u3010\u4e34\u5e8a\u836f\u7406\u3011\u7279\u6b8a\u4eba\u7fa4\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff09\u3002<\/p>\n
\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011\u5c1a\u672a\u5bf9\u672c\u54c1\u8fdb\u884c\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7814\u7a76\u3002\u6cd5\u745e\u897f\u5355\u6297\u4e0d\u5e94\u4e0e\u5176\u4ed6\u5168\u8eab\u6216\u773c\u90e8\u6297VEGF \u836f\u7269\u540c\u65f6\u7ed9\u836f\u3002<\/p>\n
\u3010\u836f\u7269\u6ee5\u7528\u548c\u836f\u7269\u4f9d\u8d56\u3011\u5c1a\u65e0\u8bc1\u636e\u8868\u660e\u672c\u54c1\u5177\u6709\u836f\u7269\u6ee5\u7528\u548c\u4f9d\u8d56\u7684\u53ef\u80fd\u6027\u3002<\/p>\n
\u3010\u836f\u7269\u8fc7\u91cf\u3011\u5c1a\u672a\u7814\u7a76\u9ad8\u4e8e\u63a8\u8350\u7ed9\u836f\u65b9\u6848\u7684\u5242\u91cf\u3002\u8d85\u8fc7\u63a8\u8350\u6ce8\u5c04\u4f53\u79ef\u7684\u836f\u7269\u8fc7\u91cf\u53ef\u80fd\u4f1a\u5bfc\u81f4IOP \u5347\u9ad8\u3002<\/p>\n
\u5982\u679c\u53d1\u751f\u836f\u7269\u8fc7\u91cf\uff0c\u5e94\u76d1\u6d4b IOP\uff0c\u5982\u679c\u4e3b\u6cbb\u533b\u751f\u8ba4\u4e3a\u6709\u5fc5\u8981\uff0c\u5e94\u8fdb\u884c\u9002\u5f53\u6cbb\u7597\u3002<\/p>\n
\u3010\u4e34\u5e8a\u836f\u7406\u3011\u4f5c\u7528\u673a\u5236<\/p>\n
\u6cd5\u745e\u897f\u5355\u6297\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u53cc\u7279\u5f02\u6027\u514d\u75ab\u7403\u86cb\u767d G1\uff08IgG1\uff09\u6297\u4f53\uff0c\u540c\u65f6\u9776\u5411\u4f5c\u7528\u4e8e\u8840\u7ba1\u751f\u6210\u7d20-2\uff08Ang-2\uff09\u548c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50 A\uff08VEGF-A\uff09\uff0c\u4ece\u800c\u5bf9\u4e24\u79cd\u4e0d\u540c\u901a\u8def\u4ea7\u751f\u6291\u5236\u4f5c\u7528\u3002<\/p>\n
Ang-2 \u901a\u8fc7\u8bf1\u5bfc\u5185\u76ae\u4e0d\u7a33\u5b9a\u3001\u5468\u7ec6\u80de\u635f\u5931\u548c\u75c5\u7406\u6027\u8840\u7ba1\u751f\u6210\uff0c\u589e\u5f3a\u8840\u7ba1\u6e17\u6f0f\u548c\u708e\u75c7\uff0c\u4ece\u800c\u5f15\u8d77\u8840\u7ba1\u4e0d\u7a33\u5b9a\u3002\u5b83\u8fd8\u4f7f\u8840\u7ba1\u5bf9 VEGF-A \u7684\u6d3b\u6027\u654f\u611f\uff0c\u5bfc\u81f4\u8fdb\u4e00\u6b65\u7684\u8840\u7ba1\u4e0d\u7a33\u5b9a\u3002Ang-2 \u548c VEGF-A \u534f\u540c\u589e\u52a0\u8840\u7ba1\u901a\u900f\u6027\uff0c\u5e76\u523a\u6fc0\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u3002<\/p>\n
\u6cd5\u745e\u897f\u5355\u6297\u901a\u8fc7\u53cc\u91cd\u6291\u5236 Ang-2 \u548c VEGF-A\uff0c\u53ef\u964d\u4f4e\u8840\u7ba1\u901a\u900f\u6027\u548c\u708e\u75c7\uff0c\u6291\u5236\u75c5\u7406\u6027\u8840\u7ba1\u751f\u6210\uff0c\u5e76\u6062\u590d\u8840\u7ba1\u7a33\u5b9a\u6027\u3002<\/p>\n
\u836f\u6548\u5b66<\/p>\n
\u5149\u5b66\u76f8\u5e72\u65ad\u5c42\u626b\u63cf\uff08OCT\uff09\u7ed3\u679c\u663e\u793a\uff0cDME \u548c nAMD \u60a3\u8005\u7684\u89c6\u7f51\u819c\u539a\u5ea6\u589e\u52a0\u3002\u8367\u5149\u8840\u7ba1\u9020\u5f71\u8bc4\u4f30\u7ed3\u679c\u663e\u793a\uff0cnAMD \u60a3\u8005\u7684\u8109\u7edc\u819c\u65b0\u751f\u8840\u7ba1\u5b58\u5728\u51fa\u8840\u548c\u6db2\u4f53\u6e17\u6f0f\u73b0\u8c61\u3002\u5728 DME \u548c nAMD \u60a3\u8005\u4e2d\u5f00\u5c55\u7684 4 \u9879 III \u671f\u7814\u7a76\u4e2d\uff0c\u6240\u6709\u6cd5\u745e\u897f\u5355\u6297\u6cbb\u7597\u7ec4\u5747\u53ef\u89c2\u5bdf\u5230\u9ec4\u6591\u4e2d\u5fc3\u51f9\u89c6\u7f51\u819c\u539a\u5ea6\uff08CST\uff09\u964d\u4f4e\u3002 <\/p>\n
\u836f\u4ee3\u52a8\u529b\u5b66<\/p>\n
\u5438\u6536<\/p>\n
\u672c\u54c1\u91c7\u7528\u73bb\u7483\u4f53\u5185\uff08IVT\uff09\u7ed9\u836f\uff0c\u4ee5\u5728\u773c\u90e8\u5c40\u90e8\u53d1\u6325\u4f5c\u7528\u3002\u5c1a\u672a\u5f00\u5c55\u5176\u4ed6\u7ed9\u836f\u9014\u5f84\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n
\u5728 nAMD \u7ee7\u53d1\u8109\u7edc\u819c\u65b0\u751f\u8840\u7ba1\u5f62\u6210\uff08CNV\uff09\u60a3\u8005\u4e2d\u5b8c\u6210\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c0.5 mg-6 mg \u5242\u91cf\u8303\u56f4\u5185\uff0c\u6cd5\u745e\u897f\u5355\u6297\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\uff08\u4ee5 Cmax\u548c AUC \u8ba1\uff09\u4e0e\u5242\u91cf\u6210\u6bd4\u4f8b\u3002\u6bcf\u6708\u4e00\u6b21\u7ed9\u836f\u540e\uff0c\u672a\u89c1\u660e\u663e\u6cd5\u745e\u897f\u5355\u6297\u84c4\u79ef\u3002<\/p>\n
\u5206\u5e03<\/p>\n
\u6839\u636e\u7fa4\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\uff08\u5305\u62ecDME \u548c nAMD\uff0cN = 2246\uff09\uff0c\u8840\u6d46\u6e38\u79bb\uff08\u672a\u4e0eVEGF-A \u548c Ang-2 \u7ed3\u5408\uff09\u6cd5\u745e\u897f\u5355\u6297\u6d53\u5ea6\u4f30\u8ba1\u5728\u7ed9\u836f\u540e\u7ea6 2 \u5929\u8fbe\u5cf0\u503c\uff08Cmax\uff09\u3002\u5728DME \u548c nAMD \u60a3\u8005\u4e2d\uff0c\u5e73\u5747\uff08\u00b1SD\uff09\u8840\u6d46 Cmax\u4f30\u8ba1\u503c\u5206\u522b\u4e3a 0.22\uff080.07\uff09\u00b5g\/ml \u548c0.23\uff080.07\uff09\u00b5g\/ml\u3002\u91cd\u590d\u7ed9\u836f\u540e\uff0c\u9884\u8ba1 Q8W \u7ed9\u836f\u7684\u5e73\u5747\u8840\u6d46\u6e38\u79bb\u6cd5\u745e\u897f\u5355\u6297\u8c37\u6d53\u5ea6\u4e3a 0.002-0.003 \u00b5g\/ml\u3002<\/p>\n
\u9884\u6d4b\u6700\u5927\u8840\u6d46\u6e38\u79bb\u6cd5\u745e\u897f\u5355\u6297\u6d53\u5ea6\u5206\u522b\u4e3a\u623f\u6c34\u548c\u73bb\u7483\u4f53\u6d53\u5ea6\u7684\u7ea6 1\/600 \u548c1\/6000\uff0c\u5e76\u4e14\u4f4e\u4e8e\u4e0e VEGF \u548c Ang-2 \u7684\u7ed3\u5408\u4eb2\u548c\u529b\u3002\u56e0\u6b64\uff0c\u4e34\u5e8a\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u6cd5\u745e\u897f\u5355\u6297\u6cbb\u7597\u540e\u8840\u6d46\u6e38\u79bb VEGF \u548c Ang-2 \u6d53\u5ea6\u65e0\u663e\u8457\u53d8\u5316\uff0c\u8fd9\u8fdb\u4e00\u6b65\u652f\u6301\u4e0d\u592a\u53ef\u80fd\u4ea7\u751f\u5168\u8eab\u836f\u6548\u4f5c\u7528\u3002<\/p>\n
\u7fa4\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\u663e\u793a\uff0c\u5e74\u9f84\u548c\u4f53\u91cd\u5206\u522b\u5bf9\u6cd5\u745e\u897f\u5355\u6297\u7684\u773c\u90e8\u6216\u5168\u8eab\u836f\u4ee3\u52a8\u529b\u5b66\u4ea7\u751f\u5f71\u54cd\u3002\u8fd9\u4e24\u79cd\u6548\u5e94\u5747\u4e0d\u5177\u6709\u4e34\u5e8a\u610f\u4e49\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<\/p>\n
\u4ee3\u8c22<\/p>\n
\u5c1a\u672a\u76f4\u63a5\u7814\u7a76\u6cd5\u745e\u897f\u5355\u6297\u7684\u4ee3\u8c22\uff0c\u56e0\u4e3a\u5355\u514b\u9686\u6297\u4f53\u4e3b\u8981\u901a\u8fc7\u5206\u89e3\u4ee3\u8c22\u6e05\u9664\u3002<\/p>\n
\u6d88\u9664<\/p>\n
IVT \u7ed9\u836f\u540e\uff0c\u6cd5\u745e\u897f\u5355\u6297\u7684\u5e73\u5747\u8868\u89c2\u5168\u8eab\u534a\u8870\u671f\u4f30\u8ba1\u4e3a 7.5 \u5929\u3002<\/p>\n
\u7279\u6b8a\u4eba\u7fa4\u7684\u836f\u4ee3\u52a8\u529b\u5b66<\/p>\n
\u513f\u7ae5\u4eba\u7fa4<\/p>\n
\u5c1a\u672a\u786e\u7acb\u672c\u54c1\u5728\u513f\u7ae5\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n
\u8001\u5e74\u4eba\u7fa4<\/p>\n
\u5728 4 \u9879 III \u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u968f\u673a\u5206\u914d\u81f3\u6cd5\u745e\u897f\u5355\u6297\u6cbb\u7597\u7ec4\u7684\u60a3\u8005\u4e2d\u7ea6 60%\uff081149\/1929\uff09\u7684\u60a3\u8005\u226565 \u5c81\u3002\u7fa4\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\u663e\u793a\uff0c\u5e74\u9f84\u5bf9\u6cd5\u745e\u897f\u5355\u6297\u7684\u773c\u90e8\u836f\u4ee3\u52a8\u529b\u5b66\u6709\u5f71\u54cd\uff0c\u4f46\u8ba4\u4e3a\u8be5\u5f71\u54cd\u65e0\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n
\u80be\u529f\u80fd\u4e0d\u5168<\/p>\n
\u5c1a\u672a\u5728\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u4e2d\u5f00\u5c55\u6b63\u5f0f\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u3002<\/p>\n
\u809d\u529f\u80fd\u4e0d\u5168<\/p>\n
\u5c1a\u672a\u5728\u809d\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u4e2d\u5f00\u5c55\u6b63\u5f0f\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u3002<\/p>\n
\u5176\u4ed6<\/p>\n
\u7fa4\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\u663e\u793a\uff0c\u4eba\u79cd\u672a\u88ab\u786e\u5b9a\u4e3a\u5f71\u54cd\u773c\u90e8\u6216\u8840\u6d46\u5904\u7f6e\u7684\u4e34\u5e8a\u76f8\u5173\u534f\u53d8\u91cf\u3002\u6cd5\u745e\u897f\u5355\u6297\u5728\u5973\u6027\u7684\u8840\u6d46\u6e05\u9664\u7387\u6162 13.7%\uff0c\u9884\u8ba1\u8be5\u5f71\u54cd\u4e0d\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n
\u3010\u4e34\u5e8a\u8bd5\u9a8c\u3011DME<\/p>\n
\u5728 DME \u60a3\u8005\u4e2d\u5f00\u5c55\u4e86\u4e24\u9879\u4e3a\u671f 2 \u5e74\u7684\u968f\u673a\u3001\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u9633\u6027\u836f\u7269\u5bf9\u7167\u7814\u7a76\uff08YOSEMITE \u548c RHINE\uff09\u4ee5\u8bc4\u4f30\u672c\u54c1\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n
\u4e24\u9879\u7814\u7a76\u5171\u8ba1\u5165\u7ec4\u4e86 1891 \u4f8b\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\u60a3\u8005\uff0c\u5171\u6709 1262 \u4f8b\u60a3\u8005\u63a5\u53d7\u4e86\u81f3\u5c11\u4e00\u6b21\u6cd5\u745e\u897f\u5355\u6297\u6cbb\u7597\u3002\u60a3\u8005\u5e74\u9f84\u5728 24 \u5c81\u81f3 91 \u5c81\u4e4b\u95f4\uff0c\u5e73\u5747\u4e3a 62.2 \u5c81\u3002\u603b\u4f53\u4eba\u7fa4\u5305\u62ec\u6297 VEGF \u521d\u6cbb\u60a3\u8005\uff0878%\uff09\u548c\u53c2\u52a0\u7814\u7a76\u524d\u63a5\u53d7\u8fc7 VEGF \u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\uff0822%\uff09\u3002<\/p>\n
\u4e24\u9879\u7814\u7a76\u7684\u8bbe\u8ba1\u5b8c\u5168\u76f8\u540c\uff1a\u4ee51:1:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u60a3\u8005\u81f3\u4ee5\u4e0b\u4e09\u4e2a\u8bd5\u9a8c\u7ec4\uff1a1\uff09\u6cd5\u745e\u897f\u5355\u6297Q8W\u7ec4\uff0c\u60a3\u8005\u63a5\u53d7\u6cd5\u745e\u897f\u5355\u62976 mg\u6bcf4\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u8fde\u7eed\u7ed9\u836f 6\u6b21\uff0c\u968f\u540e\u6bcf 8 \u5468\u7ed9\u836f\u4e00\u6b21\uff08Q8W\uff09\uff1b2\uff09\u6cd5\u745e\u897f\u5355\u6297\u4e2a\u6027\u5316\uff08PTI\uff09\u6cbb\u7597\u7ec4\uff0c\u60a3\u8005\u63a5\u53d7\u6cd5\u745e\u897f\u5355\u6297 6 mg \u6bcf 4 \u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u81f3\u5c11\u8fde\u7eed\u7ed9\u836f 4 \u6b21\uff0c\u76f4\u81f3\u901a\u8fc7\u5149\u5b66\u76f8\u5e72\u65ad\u5c42\u626b\u63cf\u6d4b\u5f97\u7684\u9ec4\u6591\u4e2d\u5fc3\u51f9\u89c6\u7f51\u819c\u539a\u5ea6\uff08CST\uff09\uff1c325 \u03bcm\uff0c\u7136\u540e\u6839\u636e\u7ed9\u836f\u8bbf\u89c6\u65f6\u7684 CST\u548c\u89c6\u529b\u60c5\u51b5\u8bc4\u4f30\u75be\u75c5\u6d3b\u52a8\u5ea6\uff0c\u6309\u7167\u7814\u7a76\u8bbe\u5b9a\u7684\u75be\u75c5\u6d3b\u52a8\u5ea6\u6807\u51c6\u8c03\u6574\u7ed9\u836f\u95f4\u9694\uff0c\u5982\u75be\u75c5\u7a33\u5b9a\uff0c\u53ef\u9010\u6b65\u5ef6\u957f\u6cbb\u7597\u95f4\u9694\uff0c\u6bcf\u6b21\u5ef6\u957f\u4e0d\u8d85\u8fc7 4 \u5468\uff0c\u5982\u75be\u75c5\u8fdb\u5c55\uff0c\u5219\u7f29\u77ed\u6cbb\u7597\u95f4\u9694\uff0c\u6bcf\u6b21\u7f29\u77ed\u4e0d\u8d85\u8fc78 \u5468\uff1b3\uff09\u963f\u67cf\u897f\u666eQ8W \u7ec4\uff0c\u60a3\u8005\u63a5\u53d7\u963f\u67cf\u897f\u666e2 mg \u6bcf4 \u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u8fde\u7eed\u7ed9\u836f5 \u6b21\uff0c\u968f\u540e\u6bcf8 \u5468\u7ed9\u836f\u4e00\u6b21\uff08Q8W\uff09\u3002<\/p>\n
\u81f3\u7b2c 96 \u5468\uff0c\u6cd5\u745e\u897f\u5355\u6297PTI \u6cbb\u7597\u7ec4\u603b\u5171\u63a5\u53d7\u6700\u5c116\u6b21\u3001\u6700\u591a21\u6b21\u6cbb\u7597\u3002\u7b2c52\u5468\u65f6\uff0cYOSEMITE \u548c RHINE \u7814\u7a76\u4e2d\uff0c\u6cd5\u745e\u897f\u5355\u6297 PTI \u7ed9\u836f\u7ec4\u5206\u522b\u6709 74%\u548c 71%\u7684\u60a3\u8005\u8fbe\u5230 Q16W \u6216 Q12W \u7ed9\u836f\u95f4\u9694\uff08Q16W \u4e3a 53%\u548c 51%\uff0cQ12W \u4e3a 21%\u548c20%\uff09\u3002\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\uff0cYOSEMITE \u548c RHINE \u7814\u7a76\u4e2d\uff0c\u5206\u522b\u6709 75%\u548c 84%\u7684\u60a3\u8005\u7ef4\u6301\u2265 Q12W \u7ed9\u836f\uff0c\u76f4\u81f3\u7b2c 96 \u5468\u95f4\u9694\u672a\u7f29\u77ed\u81f3 Q12W \u4ee5\u4e0b\uff1b\u5728\u7b2c 52 \u5468\u63a5\u53d7 Q16W\u7ed9\u836f\u7684\u60a3\u8005\u4e2d\uff0c\u5206\u522b\u6709 70%\u548c 82%\u7684\u60a3\u8005\u7ef4\u6301 Q16W \u7ed9\u836f\uff0c\u76f4\u81f3\u7b2c 96 \u5468\u672a\u7f29\u77ed\u95f4\u9694\u3002\u7b2c 96 \u5468\u65f6\uff0c\u4e24\u9879\u7814\u7a76\u4e2d\u6cd5\u745e\u897f\u5355\u6297 PTI \u7ed9\u836f\u7ec4 78%\u7684\u60a3\u8005\u8fbe\u5230Q16W \u6216Q12W\u7ed9\u836f\u95f4\u9694\uff08Q16W \u4e3a60%\u548c64%\uff0cQ12W \u4e3a 18%\u548c 14%\uff09\u3002YOSEMITE \u548c RHINE\u4e2d\u5206\u522b\u67094%\u548c6%\u7684\u60a3\u8005\u7ed9\u836f\u95f4\u9694\u5ef6\u957f\u81f3Q8W\uff0c\u5e76\u4fdd\u6301\u2264 Q8W \u81f3\u7b2c 96 \u5468\uff1b\u5206\u522b\u67093%\u548c 5%\u7684\u60a3\u8005\u4ec5\u63a5\u53d7 Q4W \u7ed9\u836f\u81f3\u7b2c 96 \u5468\u3002<\/p>\n
\u4e34\u5e8a\u7814\u7a76\u4ec5\u5165\u7ec4\u7b26\u5408\u5165\u9009\/\u6392\u9664\u6807\u51c6\u7684 DME \u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u4e0d\u77e5\u6653\u5982\u679c\u653e\u5bbd\u5165\/\u6392\u6807\u51c6\uff0c\u4e0a\u8ff0\u7ed3\u8bba\u662f\u5426\u53d1\u751f\u6539\u53d8\u3002\u672c\u7814\u7a76\u4f7f\u7528\u7684\u75be\u75c5\u6d3b\u52a8\u5ea6\u6807\u51c6\u672a\u7ecf\u5927\u89c4\u6a21\u4e34\u5e8a\u8bd5\u9a8c\u9a8c\u8bc1\u3002\u5982\u679c\u91c7\u7528\u4e0d\u540c\u6807\u51c6\uff0c\u60a3\u8005\u7684\u6cbb\u7597\u65b9\u5f0f\u53ef\u80fd\u4f1a\u6709\u6240\u6539\u53d8\uff0c\u8fdb\u800c\u5bfc\u81f4\u5404\u4e2a\u7ed9\u836f\u95f4\u9694\u961f\u5217\u4e2d\u7684\u60a3\u8005\u767e\u5206\u6bd4\u53d1\u751f\u6539\u53d8\u3002\u7531\u4e8e\u963f\u67cf\u897f\u666e\u7ec4\u7684\u7ed9\u836f\u65b9\u6848\u4e0e\u672c\u54c1\u4e0d\u540c\uff0c\u56e0\u6b64\u4e8c\u8005\u65e0\u6cd5\u6bd4\u8f83\uff0c\u5bfc\u81f4\u96be\u4ee5\u89e3\u8bfb\u4e0a\u8ff0\u767e\u5206\u6bd4\u3002<\/p>\n
\u5728\u4e3b\u8981\u7ec8\u70b9\u5373\u901a\u8fc7 ETDRS \u89c6\u529b\u8868\u8861\u91cf\u7684\u7b2c 1 \u5e74 BCVA\uff08\u7b2c 48\u300152 \u548c 56 \u5468\u8bbf\u89c6\u7684\u5e73\u5747\u503c\uff09\u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u53d8\u5316\u4e0a\uff0c\u4e24\u9879\u7814\u7a76\u5747\u8bc1\u5b9e\u4e86\u672c\u54c1\u975e\u52a3\u6548\u4e8e\u5bf9\u7167\u836f\uff08\u963f\u67cf\u897f\u666e\uff09\u3002\u4e3b\u8981\u7ec8\u70b9\u5206\u6790\u4e3a\u963f\u67cf\u897f\u666e\u548c\u6cd5\u745e\u897f\u5355\u6297\u7ec4\u4e4b\u95f4 BCVA \u5e73\u5747\u53d8\u5316\u7684\u975e\u52a3\u6548\u6027\u6bd4\u8f83\u3002\u975e\u52a3\u6548\u6027\u6807\u51c6\u4e3a BCVA \u5e73\u5747\u53d8\u5316\u7684 97.5%\u7f6e\u4fe1\u533a\u95f4\u4e0b\u9650\u4e0d\u4f4e\u4e8e-4 \u4e2a\u5b57\u6bcd\u6570\u3002\u5728\u4e24\u9879\u7814\u7a76\u4e2d\uff0c\u4e0e\u63a5\u53d7\u963f\u67cf\u897f\u666e Q8W \u6cbb\u7597\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u63a5\u53d7\u6cd5\u745e\u897f\u5355\u6297Q8W \u548c\u6cd5\u745e\u897f\u5355\u6297 PTI \u6cbb\u7597\u7684\u60a3\u8005\u5728\u4e3b\u8981\u7ec8\u70b9\u5373\u7b2c 1 \u5e74 BCVA \u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u53d8\u5316\u4e0a\u5177\u6709\u975e\u52a3\u6548\u6027\uff0c\u4e14\u89c6\u529b\u63d0\u9ad8\u7ef4\u6301\u81f3\u7b2c 2 \u5e74\u3002\u4e24\u9879\u7814\u7a76\u7684\u8be6\u7ec6\u7ed3\u679c\u5982\u4e0b\u8868 2\u3001\u56fe 1\u548c\u56fe 2 \u6240\u793a\u3002<\/p>\n
\u8868 2\uff1aYOSEMITE \u548c RHINE \u7b2c 1 \u5e74 a\u548c\u7b2c 2 \u5e74 b\u7684\u6709\u6548\u6027\u7ed3\u679c<\/p>\n<\/p>\n
a \u7b2c 48\u300152\u300156 \u5468\u7684\u5e73\u5747\u503c<\/p>\n
b \u7b2c 92\u300196\u3001100 \u5468\u7684\u5e73\u5747\u503c<\/p>\n
c \u975e\u52a3\u6548\u6027\u754c\u503c\u7b2c 2 \u5e74\u4e0d\u53ef\u7528<\/p>\n
BCVA\uff1a\u6700\u4f73\u77eb\u6b63\u89c6\u529b<\/p>\n
ETDRS\uff1a\u65e9\u671f\u6cbb\u7597\u7cd6\u5c3f\u75c5\u6027\u89c6\u7f51\u819c\u75c5\u53d8\u7814\u7a76<\/p>\n
CI\uff1a\u7f6e\u4fe1\u533a\u95f4<\/p>\n
LS\uff1a\u6700\u5c0f\u4e8c\u4e58\u6cd5<\/p>\n
Q8W\uff1a\u6bcf 8 \u5468\u4e00\u6b21<\/p>\n
PTI\uff1a\u4e2a\u6027\u5316\u6cbb\u7597\u95f4\u9694<\/p>\n
\u56fe1\uff1aYOSEMITE\u4e2d\u81f3\u7b2c2\u5e74\uff08\u7b2c100\u5468\uff09BCVA\u8f83\u57fa\u7ebf\u7684\u53d8\u5316<\/p>\n<\/p>\n
\u56fe2\uff1aRHINE\u4e2d\u81f3\u7b2c2\u5e74\uff08\u7b2c100\u5468\uff09BCVA\u8f83\u57fa\u7ebf\u7684\u53d8\u5316<\/p>\n<\/p>\n
\u5728\u53c2\u52a0\u7814\u7a76\u524d\u672a\u63a5\u53d7\u8fc7\u6297 VEGF \u6cbb\u7597\u7684\u60a3\u8005\u4e9a\u7ec4\u4e2d\uff0c\u6709\u6548\u6027\u7ed3\u679c\u4e0e\u603b\u4eba\u7fa4\u4e2d\u89c2\u5bdf\u5230\u7684\u7ed3\u679c\u76f8\u4f3c\u3002\u6bcf\u9879\u7814\u7a76\u4e2d\u53ef\u8bc4\u4ef7\u4e9a\u7ec4\uff08\u5982\u5e74\u9f84\u3001\u6027\u522b\u3001\u4eba\u79cd\u3001\u57fa\u7ebf HbA1c\u3001\u57fa\u7ebf\u89c6\u529b\uff09\u7684\u6709\u6548\u6027\u7ed3\u679c\u4e0e\u603b\u4eba\u7fa4\u7684\u7ed3\u679c\u57fa\u672c\u4e00\u81f4\u3002<\/p>\n
\u4e24\u9879\u7814\u7a76\u7684\u5173\u952e\u6b21\u8981\u6709\u6548\u6027\u7ec8\u70b9\u4e3a\u7b2c 52 \u5468\u65f6 ETDRS-\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u4e25\u91cd\u7a0b\u5ea6\u91cf\u8868\uff08ETDRS-DRSS\uff09\u76f8\u5bf9\u4e8e\u57fa\u7ebf\u6539\u5584\u22652 \u7ea7\u7684\u60a3\u8005\u6bd4\u4f8b\u3002\u5728\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u4e0a\uff0c\u4f7f\u7528\u975e\u52a3\u6548\u6027\u754c\u503c 10%\u8fdb\u884c\u5047\u8bbe\u68c0\u9a8c\u3002\u4e24\u9879\u7814\u7a76\u4e2d\uff0cYOSEMITE \u7814\u7a76\u5bf9\u4e8e DRSS \u6539\u5584\u22652 \u7ea7\u7684\u60a3\u8005\u6bd4\u4f8b\uff0c\u8fbe\u5230\u4e86\u975e\u52a3\u6548\u6027\uff1bRHINE \u7814\u7a76\u5bf9\u4e8e DRSS \u6539\u5584\u22652 \u7ea7\u7684\u60a3\u8005\u6bd4\u4f8b\uff0c\u672a\u8fbe\u5230\u975e\u52a3\u6548\u6027\u3002\u4e24\u9879\u7814\u7a76\u7684\u8be6\u7ec6\u7ed3\u679c\u5982\u4e0b\u8868 3 \u6240\u793a\u3002<\/p>\n
\u8868 3\uff1aYOSEMITE \u548c RHINE \u4e2d\u7b2c52\u5468\u548c\u7b2c96\u5468\u65f6ETDRS-DRSS\u8bc4\u5206\u76f8\u5bf9\u4e8e\u57fa\u7ebf\u6539\u5584\u22652\u7ea7\u7684\u60a3\u8005\u6bd4\u4f8b\uff08DR \u53ef\u8bc4\u4ef7\u4eba\u7fa4\uff09<\/p>\n<\/p>\n
ETDRS-DRSS\uff1a\u65e9\u671f\u6cbb\u7597\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u7814\u7a76-\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u4e25\u91cd\u7a0b\u5ea6\u91cf\u8868<\/p>\n
CMH\uff1aCochran\u2013Mantel\u2013Haenszel \u65b9\u6cd5\uff1b\u4e00\u79cd\u7edf\u8ba1\u68c0\u9a8c\u65b9\u6cd5\uff0c\u53ef\u4f30\u8ba1\u4e8c\u5143\u7ec8\u70b9\uff0c\u7528\u4e8e\u8bc4\u4f30\u5206\u7c7b\u53d8\u91cf\u3002<\/p>\n
CI\uff1a\u7f6e\u4fe1\u533a\u95f4<\/p>\n
Q8W\uff1a\u6bcf 8 \u5468\u4e00\u6b21<\/p>\n
PTI\uff1a\u4e2a\u6027\u5316\u6cbb\u7597\u95f4\u9694<\/p>\n
\u6ce8\uff1a\u4e0a\u8ff0\u7ed3\u679c\u91cc\u963f\u67cf\u897f\u666e\u7ec4\u7684 CMH \u52a0\u6743\u6bd4\u4f8b%\u662f\u57fa\u4e8e\u6cd5\u745e\u897f\u5355\u6297 Q8W \u7ec4\u4e0e\u963f\u67cf\u897f\u666e\u7ec4\u7684\u6bd4\u8f83\uff0c\u57fa\u4e8e\u6cd5\u745e\u897f\u5355\u6297 PTI \u7ed9\u836f\u7ec4\u4e0e\u963f\u67cf\u897f\u666e\u7ec4\u6bd4\u8f83\u7684\u963f\u67cf\u897f\u666e\u7ec4\u7684 CMH \u52a0\u6743\u6bd4\u4f8b%\u4e0e\u4e0a\u8ff0\u7ed3\u679c\u76f8\u4f3c\u3002<\/p>\n
\u4e2d\u56fd\u53c2\u52a0\u4e86 RHINE \u7814\u7a76\uff0c\u5171\u5165\u7ec4 152 \u4f8b\u4e2d\u56fd\u60a3\u8005\uff0c\u968f\u673a\u5206\u914d\u63a5\u53d7\u524d\u6587\u6240\u8ff0\u7684\u6cbb\u7597\u65b9\u6848\u3002\u4e2d\u56fd\u4e9a\u7fa4\u7b2c 1 \u5e74\u5206\u6790\u7ed3\u679c\u663e\u793a\uff1a\u4e24\u79cd\u6cd5\u745e\u897f\u5355\u6297\u6cbb\u7597\u65b9\u6848\u5747\u89c2\u5bdf\u5230\u4e2d\u56fd\u4eba\u7fa4\u7684\u6709\u6548\u6027\u7ed3\u679c\u4e0e\u5168\u7403\u4eba\u7fa4\u57fa\u672c\u4e00\u81f4\u3002\u8be6\u7ec6\u7ed3\u679c\u5982\u4e0b\u8868 4 \u6240\u793a\u3002<\/p>\n
\u8868 4\uff1aRHINE\u7684\u6709\u6548\u6027\u7ed3\u679c\uff1a\u4e2d\u56fd\u4e9a\u7fa4\u548c\u5168\u7403\u4eba\u7fa4<\/p>\n<\/p>\n
a \u7b2c 48\u300152\u300156 \u5468\u7684\u5e73\u5747\u503c<\/p>\n
b \u63d0\u4f9b\u4e86\u4e2d\u56fd\u4e9a\u7fa4\u7684 95% CI\u3001\u5168\u7403\u4eba\u7fa4\u7684 97.5% CI<\/p>\n
c \u4e2d\u56fd\u4e9a\u7fa4\u4e3a\u975e\u5206\u5c42\u7ed3\u679c\uff0c\u5168\u7403\u4eba\u7fa4\u4e3a CMH \u52a0\u6743\u5206\u5c42\u7ed3\u679c<\/p>\n
d \u4e2d\u56fd\u4e9a\u7fa4\u548c\u5168\u7403\u4eba\u7fa4\u7684\u975e\u5206\u5c42\u7ed3\u679c<\/p>\n
BCVA\uff1a\u6700\u4f73\u77eb\u6b63\u89c6\u529b<\/p>\n
ETDRS\uff1a\u65e9\u671f\u6cbb\u7597\u7cd6\u5c3f\u75c5\u6027\u89c6\u7f51\u819c\u75c5\u53d8\u7814\u7a76<\/p>\n
DRSS\uff1a\u7cd6\u5c3f\u75c5\u6027\u89c6\u7f51\u819c\u75c5\u4e25\u91cd\u7a0b\u5ea6\u91cf\u8868<\/p>\n
CI\uff1a\u7f6e\u4fe1\u533a\u95f4<\/p>\n
Q4W\uff1a\u6bcf 4 \u5468\u4e00\u6b21\uff1bQ8W\uff1a\u6bcf 8 \u5468\u4e00\u6b21\uff1bQ12W\uff1a\u6bcf 12 \u5468\u4e00\u6b21\uff1bQ16W\uff1a\u6bcf 16 \u5468\u4e00\u6b21\uff1b<\/p>\n
PTI\uff1a\u4e2a\u6027\u5316\u6cbb\u7597\u95f4\u9694<\/p>\n
nAMD<\/p>\n
\u5728 nAMD \u60a3\u8005\u4e2d\u5f00\u5c55\u4e86\u4e24\u9879\u4e3a\u671f 2 \u5e74\u7684\u968f\u673a\u3001\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u9633\u6027\u836f\u7269\u5bf9\u7167\u7814\u7a76\uff08TENAYA \u548c LUCERNE\uff09\u4ee5\u8bc4\u4f30\u672c\u54c1\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n
\u4e24\u9879\u7814\u7a76\u5171\u8ba1\u5165\u7ec4\u4e86 1329 \u4f8b\u521d\u8bca\u521d\u6cbb\u60a3\u8005\uff0c664 \u4f8b\u60a3\u8005\u63a5\u53d7\u4e86\u81f3\u5c11\u4e00\u6b21\u672c\u54c1\u7ed9\u836f\u3002\u60a3\u8005\u5e74\u9f84\u5728 50 \u5c81\u81f3 99 \u5c81\u4e4b\u95f4\uff0c\u5e73\u5747\u4e3a 75.9 \u5c81\u3002\u4e24\u9879\u7814\u7a76\u7684\u8bbe\u8ba1\u5b8c\u5168\u76f8\u540c\uff0c\u5747\u4e3a\u671f 2 \u5e74\u3002\u4ee5 1:1 \u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u60a3\u8005\u81f3\u4e24\u4e2a\u6cbb\u7597\u7ec4\u4e4b\u4e00\uff1a1\u3001\u60a3\u8005\u63a5\u53d7\u6cd5\u745e\u897f\u5355\u6297 6 mg \u6bcf 4 \u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u8fde\u7eed\u7ed9\u836f 4 \u6b21\uff0c\u5728\u5b8c\u6210\u7ed9\u836f 4 \u6b21\u540e\u7684\u7b2c 8\u5468\u548c\u7b2c 12 \u5468\u8fdb\u884c OCT \u548c\u89c6\u529b\u8bc4\u4f30\uff0c\u786e\u5b9a\u662f\u5426\u6839\u636e\u4ee5\u4e0b\u4e09\u79cd\u65b9\u6848\u4e4b\u4e00\u7ee7\u7eed\u7ed9\u836f\uff1a1\uff09\u7b2c 28 \u548c 44 \u5468\uff08\u5373\u6bcf 16 \u5468\u7ed9\u836f\u4e00\u6b21\uff0cQ16W\uff09\uff1b2\uff09\u7b2c 24\u300136 \u548c 48 \u5468\uff08\u5373\u6bcf 12 \u5468\u7ed9\u836f\u4e00\u6b21\uff0cQ12W\uff09\u6216 3\uff09\u7b2c 20\u300128\u300136 \u548c 44 \u5468\uff08\u5373\u6bcf 8 \u5468\u7ed9\u836f\u4e00\u6b21\uff0cQ8W\uff09\u30022\u3001\u963f\u67cf\u897f\u666e 2 mg \u56fa\u5b9a\u5242\u91cf\u6bcf\u6708\u7ed9\u836f\u4e00\u6b21\uff0c\u8fde\u7eed\u7ed9\u836f 3 \u6b21\uff0c\u968f\u540e\u6bcf 8 \u5468\u7ed9\u836f\u4e00\u6b21\uff08Q8W\uff09\u3002<\/p>\n
\u7b2c 48 \u5468\u65f6\uff0c\u6cd5\u745e\u897f\u5355\u6297\u7ec4\u5728\u6309\u6bcf\u6708\u4e00\u6b21\u65b9\u6848\u5b8c\u6210\u524d 4 \u6b21\u7ed9\u836f\u540e\uff0c\u6709 45%\u7684\u60a3\u8005\u63a5\u53d7 Q16W \u7ed9\u836f\uff0c\u6709 33%\u7684\u60a3\u8005\u63a5\u53d7 Q12W \u7ed9\u836f\uff0c\u5176\u4f59 22%\u7684\u60a3\u8005\u63a5\u53d7Q8W \u7ed9\u836f\u3002\u4e0a\u8ff0\u767e\u5206\u6bd4\u53cd\u6620\u4e86\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u60c5\u51b5\uff0c\u8868\u660e\u90e8\u5206\u60a3\u8005\u5728\u95f4\u9694 16\u5468\u7684 2 \u6b21\u7ed9\u836f\u6216\u95f4\u9694 12 \u5468\u7684 3 \u6b21\u7ed9\u836f\u4e2d\u8868\u73b0\u826f\u597d\uff0c\u4f46\u7531\u4e8e\u5404\u79cd\u539f\u56e0\uff0c\u8be5\u767e\u5206\u6bd4\u53ef\u80fd\u65e0\u6cd5\u5916\u63a8\u81f3\u66f4\u5e7f\u6cdb\u7684 nAMD \u4eba\u7fa4\u3002\u4e34\u5e8a\u8bd5\u9a8c\u4ec5\u5165\u7ec4\u7b26\u5408\u5165\u9009\/\u6392\u9664\u6807\u51c6\u7684\u521d\u8bca\u521d\u6cbb\u7684 nAMD \u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u4e0d\u77e5\u6653\u5982\u679c\u653e\u5bbd\u5165\/\u6392\u6807\u51c6\uff0c\u4e0a\u8ff0\u7ed3\u8bba\u662f\u5426\u53d1\u751f\u6539\u53d8\u3002\u672c\u7814\u7a76\u4f7f\u7528\u7684\u75be\u75c5\u6d3b\u52a8\u5ea6\u6807\u51c6\u672a\u7ecf\u5927\u89c4\u6a21\u4e34\u5e8a\u8bd5\u9a8c\u9a8c\u8bc1\u3002\u5982\u679c\u91c7\u7528\u4e0d\u540c\u6807\u51c6\uff0c\u60a3\u8005\u7684\u6cbb\u7597\u65b9\u5f0f\u53ef\u80fd\u4f1a\u6539\u53d8\uff0c\u8fdb\u800c\u5bfc\u81f4\u91c7\u7528\u5404\u4e2a\u7ed9\u836f\u95f4\u9694\u7684\u60a3\u8005\u767e\u5206\u6bd4\u53d1\u751f\u6539\u53d8\u3002\u7531\u4e8e\u963f\u67cf\u897f\u666e\u7ec4\u7684\u7ed9\u836f\u65b9\u6848\u4e0e\u672c\u54c1\u4e0d\u540c\uff0c\u56e0\u6b64\u4e8c\u8005\u65e0\u6cd5\u6bd4\u8f83\uff0c\u5bfc\u81f4\u96be\u4ee5\u89e3\u8bfb\u4e0a\u8ff0\u767e\u5206\u6bd4\u3002<\/p>\n
\u5728\u4e3b\u8981\u7ec8\u70b9\u5373\u901a\u8fc7 ETDRS \u89c6\u529b\u8868\u8861\u91cf\u7684\u7b2c 1 \u5e74 BCVA\uff08\u7b2c 40\u300144 \u548c 48\u5468\u8bbf\u89c6\u7684\u5e73\u5747\u503c\uff09\u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u53d8\u5316\u4e0a\uff0c\u4e24\u9879\u7814\u7a76\u5747\u8bc1\u5b9e\u4e86\u672c\u54c1\u975e\u52a3\u6548\u4e8e\u5bf9\u7167\u836f\uff08\u963f\u67cf\u897f\u666e\uff09\u3002\u4e3b\u8981\u7ec8\u70b9\u5206\u6790\u4e3a\u963f\u67cf\u897f\u666e\u548c\u6cd5\u745e\u897f\u5355\u6297\u7ec4\u4e4b\u95f4 BCVA \u5e73\u5747\u53d8\u5316\u7684\u975e\u52a3\u6548\u6027\u6bd4\u8f83\u3002\u975e\u52a3\u6548\u6027\u6807\u51c6\u4e3a BCVA \u5e73\u5747\u53d8\u5316\u7684 95%\u7f6e\u4fe1\u533a\u95f4\u4e0b\u9650\u4e0d\u4f4e\u4e8e-4 \u4e2a\u5b57\u6bcd\u6570\u3002\u5728\u4e24\u9879\u7814\u7a76\u4e2d\uff0c\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u7684 BCVA \u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u53d8\u5316\u975e\u52a3\u6548\u4e8e\u63a5\u53d7\u963f\u67cf\u897f\u666e\u6cbb\u7597\u7684\u60a3\u8005\u3002\u4e24\u9879\u7814\u7a76\u7684\u8be6\u7ec6\u7ed3\u679c\u89c1\u4e0b\u8868 5\u3001\u56fe 3 \u548c\u56fe 4\u3002<\/p>\n
\u8868 5\uff1aTENAYA \u548c LUCERNE \u7b2c 1 \u5e74 a\u7684\u6709\u6548\u6027\u7ed3\u679c<\/p>\n<\/p>\n
a \u7b2c 40\u300144 \u548c 48 \u5468\u7684\u5e73\u5747\u503c<\/p>\n
BCVA\uff1a\u6700\u4f73\u77eb\u6b63\u89c6\u529b\uff1bETDRS\uff1a\u65e9\u671f\u6cbb\u7597\u7cd6\u5c3f\u75c5\u6027\u89c6\u7f51\u819c\u75c5\u53d8\u7814\u7a76\uff1bCI\uff1a\u7f6e\u4fe1\u533a\u95f4\uff1b<\/p>\n
LS\uff1a\u6700\u5c0f\u4e8c\u4e58\u6cd5<\/p>\n
\u56fe 3\uff1aTENAYA \u4e2d\u81f3\u7b2c 1 \u5e74\uff08\u7b2c 48 \u5468\uff09BCVA \u8f83\u57fa\u7ebf\u7684\u53d8\u5316<\/p>\n<\/p>\n
\u56fe4\uff1aLUCERNE\u4e2d\u81f3\u7b2c1\u5e74\uff08\u7b2c48\u5468\uff09BCVA\u8f83\u57fa\u7ebf\u7684\u53d8\u5316<\/p>\n<\/p>\n
\u6bcf\u9879\u7814\u7a76\u4e2d\u53ef\u8bc4\u4ef7\u4e9a\u7ec4\uff08\u5982\u5e74\u9f84\u3001\u6027\u522b\u3001\u4eba\u79cd\u3001\u57fa\u7ebf\u89c6\u529b\uff09\u7684\u6709\u6548\u6027\u7ed3\u679c\u4e0e\u603b\u4eba\u7fa4\u7684\u7ed3\u679c\u57fa\u672c\u4e00\u81f4\u3002<\/p>\n
\u4e2d\u56fd\u53c2\u52a0\u4e86 LUCERNE \u7814\u7a76\uff0c\u5171\u5165\u7ec4 119 \u4f8b\u4e2d\u56fd\u60a3\u8005\uff0c\u968f\u673a\u5206\u914d\u63a5\u53d7\u524d\u6587\u6240\u8ff0\u7684\u6cbb\u7597\u65b9\u6848\u3002\u4e2d\u56fd\u4e9a\u7fa4\u7b2c 1 \u5e74\u5206\u6790\u7ed3\u679c\u663e\u793a\uff1a\u6cd5\u745e\u897f\u5355\u6297\u7ec4\u89c2\u5bdf\u5230\u4e2d\u56fd\u4eba\u7fa4\u7684\u6709\u6548\u6027\u7ed3\u679c\u4e0e\u5168\u7403\u4eba\u7fa4\u57fa\u672c\u4e00\u81f4\u3002\u8be6\u7ec6\u7ed3\u679c\u5982\u4e0b\u8868 6 \u6240\u793a\u3002<\/p>\n
\u8868 6\uff1aLUCERNE \u7684\u6709\u6548\u6027\u7ed3\u679c\uff1a\u4e2d\u56fd\u4e9a\u7fa4\u548c\u5168\u7403\u4eba\u7fa4<\/p>\n<\/p>\n
a \u7b2c 40\u300144 \u548c 48 \u5468\u7684\u5e73\u5747\u503c<\/p>\n
BCVA\uff1a\u6700\u4f73\u77eb\u6b63\u89c6\u529b<\/p>\n
ETDRS\uff1a\u65e9\u671f\u6cbb\u7597\u7cd6\u5c3f\u75c5\u6027\u89c6\u7f51\u819c\u75c5\u53d8\u7814\u7a76<\/p>\n
CI\uff1a\u7f6e\u4fe1\u533a\u95f4<\/p>\n
Q8W\uff1a\u6bcf 8 \u5468\u4e00\u6b21<\/p>\n
Q12W\uff1a\u6bcf 12 \u5468\u4e00\u6b21<\/p>\n
Q16W\uff1a\u6bcf 16 \u5468\u4e00\u6b21<\/p>\n
\u3010\u836f\u7406\u6bd2\u7406\u3011\u836f\u7406\u4f5c\u7528<\/p>\n
\u6cd5\u745e\u897f\u5355\u6297\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u901a\u8fc7\u4e0e VEGF-A \u548c Ang-2 \u7ed3\u5408\u800c\u6291\u5236\u4e24\u6761\u901a\u8def\u53d1\u6325\u4f5c\u7528\uff1a\u901a\u8fc7\u6291\u5236 VEGF-A\uff0c\u6cd5\u745e\u897f\u5355\u6297\u53ef\u6291\u5236\u5185\u76ae\u7ec6\u80de\u589e\u6b96\u3001\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u548c\u8840\u7ba1\u901a\u900f\u6027\uff1b\u901a\u8fc7\u6291\u5236 Ang-2\uff0c\u6cd5\u745e\u897f\u5355\u6297\u53ef\u63d0\u9ad8\u8840\u7ba1\u7a33\u5b9a\u6027\u5e76\u964d\u4f4e\u8840\u7ba1\u5bf9 VEGF-A \u7684\u654f\u611f\u6027\u3002\u5728\u4e00\u4e9b DME \u548c nAMD \u60a3\u8005\u4e2d\u53ef\u89c1 Ang-2 \u6c34\u5e73\u5347\u9ad8\uff0cAng-2 \u7684\u6291\u5236\u5bf9 DME \u548c nAMD \u7684\u6cbb\u7597\u4f5c\u7528\u53ca\u4e34\u5e8a\u5e94\u7b54\u7684\u8d21\u732e\u5c1a\u5f85\u786e\u5b9a\u3002<\/p>\n
\u6bd2\u7406\u7814\u7a76<\/p>\n
\u9057\u4f20\u6bd2\u6027<\/p>\n
\u672a\u5f00\u5c55\u6cd5\u745e\u897f\u5355\u6297\u7684\u9057\u4f20\u6bd2\u6027\u8bd5\u9a8c\u3002<\/p>\n
\u751f\u6b96\u6bd2\u6027<\/p>\n
\u6839\u636e\u6cd5\u745e\u897f\u5355\u6297\u7684\u6297 VEGF \u548c Ang-2 \u7684\u4f5c\u7528\u673a\u5236\u63a8\u6d4b\uff0c\u6cd5\u745e\u897f\u5355\u6297\u53ef\u80fd\u5bf9\u5973\u6027\u751f\u6b96\u80fd\u529b\u548c\u80da\u80ce-\u80ce\u513f\u53d1\u80b2\u5177\u6709\u6f5c\u5728\u98ce\u9669\u3002<\/p>\n
\u5728\u598a\u5a20\u98df\u87f9\u7334\u80da\u80ce-\u80ce\u4ed4\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\u4e2d\uff0c\u4ece\u598a\u5a20\u7b2c 20 \u5929\u5f00\u59cb\u9759\u8109\u6ce8\u5c04\u6cd5\u745e\u897f\u5355\u6297 1\u30013 mg\/kg\uff0c\u6bcf\u5468\u7ed9\u836f1\u6b21\uff0c\u5171\u7ed9\u836f5\u6b21\uff0c\u4e24\u4e2a\u5242\u91cf\u4e0b\u89c2\u5bdf\u5230\u598a\u5a20\u4e22\u5931\uff08\u6d41\u4ea7\uff09\u5448\u975e\u5242\u91cf\u4f9d\u8d56\u6027\u589e\u52a0\u3002\u5728\u4f4e\u5242\u91cf 1 mg\/kg \u4e0b\uff0c\u598a\u5a20\u98df\u87f9\u7334\u7684\u8840\u6e05\u66b4\u9732\u91cf\uff08Cmax\uff09\u662f\u4eba\u6700\u5927\u63a8\u8350\u5242\u91cf\uff08\u6bcf\u6b21 6 mg\uff0c\u6bcf4\u5468\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u4e00\u6b21\uff09\u4e0b\u66b4\u9732\u91cf\u7684158\u500d\u3002\u8be5\u8bd5\u9a8c\u672a\u786e\u5b9a\u672a\u89c1\u4e0d\u826f\u53cd\u5e94\u5242\u91cf\u3002<\/p>\n
\u81f4\u764c\u6027<\/p>\n
\u672a\u5f00\u5c55\u6cd5\u745e\u897f\u5355\u6297\u7684\u81f4\u764c\u6027\u8bd5\u9a8c\u3002<\/p>\n
\u3010\u8d2e\u85cf\u3011\u5c06\u836f\u74f6\u7f6e\u4e8e\u539f\u5305\u88c5\u76d2\u4e2d\u4e8e2\u2103~8\u2103\u907f\u5149\u4fdd\u5b58\u3002\u8bf7\u52ff\u51b7\u51bb\uff0c\u8bf7\u52ff\u632f\u6447\u3002\u57282\u00b0C ~ 8\u00b0C \u4e0b\u8fd0\u8f93\u4ea7\u54c1\u3002<\/p>\n
\u4f7f\u7528\u524d\uff0c\u672a\u5f00\u5c01\u7684\u836f\u74f6\u53ef\u5728 20\u00b0C~25\u00b0C \u6761\u4ef6\u4e0b\u4fdd\u5b58 24 \u5c0f\u65f6\u3002<\/p>\n
\u786e\u4fdd\u5728\u4e34\u5e8a\u4f7f\u7528\u5242\u91cf\u51c6\u5907\u5b8c\u6210\u540e\u7acb\u5373\u6ce8\u5c04\u3002<\/p>\n
\u3010\u5305\u88c5\u3011\u897f\u6797\u74f6\u88c5\uff0c1 \u74f6\/\u76d2\uff0c\u5185\u9644 1 \u4e2a\u8f6c\u79fb\u7528\u8fc7\u6ee4\u9488\u5934\u3002<\/p>\n
\u3010\u6709\u6548\u671f\u301130 \u4e2a\u6708<\/p>\n
\u3010\u751f\u4ea7\u4f01\u4e1a\u3011\u4f01\u4e1a\u540d\u79f0\uff1aF. Hoffmann-La Roche AG<\/p>\n
\u751f\u4ea7\u5730\u5740\uff1aWurmisweg, Kaiseraugst 4303, Switzerland<\/p>\n
\u3010\u5883\u5185\u8054\u7cfb\u4eba\u3011\u540d \u79f0\uff1a\u4e0a\u6d77\u7f57\u6c0f\u5236\u836f\u6709\u9650\u516c\u53f8<\/p>\n
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\u90ae\u653f\u7f16\u7801\uff1a201203<\/p>\n
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