\u672c\u6587\u51718100\u5b57\uff0c\u9605\u8bfb\u65f6\u95f4\uff1a35\u5206\u949f\u6587\u7ae0\u8f83\u957f\uff0c\u5efa\u8bae\u5148\u6536\u85cf\u518d\u9605\u8bfb\u6587\u7ae0\u8f6c\u8f7d\u8bf7\u6807\u660e\u6765\u6e90<\/p>\n
2024\u5e748\u670827\u65e5\u4e00\u573a\u8bb0\u8005\u4f1a\u4e0a\uff0c96\u5c81\u7684\u9999\u6e2f\u9996\u5bcc\u674e\u5609\u8bda\u89c6\u9891\u73b0\u8eab\u8bb0\u8005\u4f1a\uff0c\u901a\u8fc7\u76f4\u64ad\u89c2\u770b\u4e86\u9999\u6e2f\u5927\u5b66\u533b\u5b66\u9662\u4e34\u5e8a\u6559\u6388\u9648\u667a\u4ec1\u64cd\u4f5cHistotripsy\u7cfb\u7edf\uff0c\u8be5\u4eea\u5668\u53d1\u5c04\u7684\u9ad8\u5f3a\u5ea6\u8d85\u58f0\u6ce2\u57285\u5206\u949f\u5185\u5c06\u6a21\u62df\u809d\u810f\u7ec4\u7ec7\u4e2d\u7684\u764c\u7ec6\u80de\u51fb\u788e\u5e76\u5c06\u5176\u5316\u4e3a\u6db2\u4f53\uff0c\u5f15\u53d1\u4e1a\u5185\u548c\u5b66\u754c\u5173\u6ce8\u3002<\/p>\n
Histotripsy\uff08\u8d85\u58f0\u6ce2\u7ec4\u7ec7\u788e\u5316\u6280\u672f\uff09\u662f\u4e00\u79cd\u65b0\u7684\u65e0\u521b\u6cbb\u7597\u6280\u672f\uff0c\u53ef\u4ee5\u5229\u7528\u9ad8\u5f3a\u5ea6\u8d85\u58f0\u6ce2\u7cbe\u51c6\u7834\u574f\u809d\u764c\u7ec6\u80de\uff0c\u65e0\u9700\u5f00\u5200\u505a\u624b\u672f\u5c31\u53ef\u6d88\u706d\u80bf\u7624\uff0c\u7531\u7f8e\u56fd\u5bc6\u6b47\u6839\u5927\u5b66\u4e8e2001\u5e74\u7814\u53d1\u3002<\/p>\n
2019\u5e74\uff0cHistotripsy\u7528\u4e8e\u809d\u764c\u6cbb\u7597\u7684\u4e00\u671f\u4e34\u5e8a\u7814\u7a76\u5b8c\u6210\u30022023\u5e7410\u6708\u8be5\u6280\u672f\u83b7\u5f97FDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u809d\u810f\u80bf\u7624\uff0c\u73b0\u5df2\u6709400\u591a\u540d\u60a3\u8005\u5728\u7f8e\u56fd\u533b\u7597\u673a\u6784\u63a5\u53d7\u8fd9\u9879\u6cbb\u7597\u3002\u6e2f\u5927\u533b\u5b66\u9662\u662f\u4e9a\u6d32\u9996\u4e2a\u5f15\u8fdb\u8be5\u533b\u7597\u5668\u6750\u6280\u672f\u8fdb\u884c\u4e34\u5e8a\u8bd5\u70b9\u7684\u673a\u6784\u3002<\/p>\n
\u76ee\u524d\u4e34\u5e8a\u6700\u5e38\u7528\u7684\u6d88\u878d\u672f\uff0c\u5305\u62ec\u5c04\u9891\u6d88\u878d\u672f\u3001\u5fae\u6ce2\u6d88\u878d\u672f\u3001\u548c\u51b7\u51bb\u6d88\u878d\u672f\u3002\u6b64\u5916\uff0c\u8fd8\u6709\u9ad8\u5f3a\u5ea6\u805a\u7126\u8d85\u58f0\uff08HIFU\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u65e0\u521b\u70ed\u6d88\u878d\u6280\u672f\uff0c\u5229\u7528\u5916\u90e8\u65bd\u52a0\u7684\u8d85\u58f0\u80fd\u91cf\u5f15\u8d77\u70ed\u574f\u6b7b\u3002HIFU \u5df2\u5728\u4e34\u5e8a\u4e0a\u7528\u4e8e\u6cbb\u7597\u5b50\u5bab\u808c\u7624\u3001\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4ee5\u53ca\u524d\u5217\u817a\u3001\u4e73\u817a\u764c\u3001\u809d\u810f\u548c\u80f0\u817a\u80bf\u7624\uff0c\u4f46\u7531\u4e8e\u89e3\u5256\u5b66\u6311\u6218\u548c\u624b\u672f\u65f6\u95f4\u957f\uff0c\u5176\u4e34\u5e8a\u4f7f\u7528\u4ecd\u7136\u4e0d\u5e38\u89c1\u3002Histotripsy\u662f\u4e00\u79cd\u7c7b\u4f3c\u4e8eHIFU\u7684\u65e0\u521b\u805a\u7126\u8d85\u58f0\u6280\u672f\u3002\u7136\u800c\uff0c\u7ec4\u7ec7\u5207\u9664\u672f\u7684\u6f5c\u5728\u673a\u5236\u4ece\u6839\u672c\u4e0a\u4e0d\u540c\uff0c\u800c\u662f\u4f9d\u9760\u7ec6\u80de\u6c34\u5e73\u7684\u673a\u68b0\u6548\u5e94\u6765\u7834\u574f\u7ec4\u7ec7\u3002<\/p>\n
\u672c\u6587\u5c06\u4e3a\u5927\u5bb6\u8be6\u7ec6\u4ecb\u7ecdHistotripsy\u8fd9\u4e00\u6280\u672f\u3002<\/p>\n<\/p>\n
Histotripsy\u662f\u4ec0\u4e48\uff1f<\/p>\n
Histotripsy\u662f\u7b2c\u4e00\u4e2a\u7531\u5b9e\u65f6\u6210\u50cf\u5f15\u5bfc\u7684\u65e0\u521b\u3001\u975e\u7535\u79bb\u548c\u975e\u70ed\u6d88\u878d\u6280\u672f\u3002<\/p>\n
Histotripsy\u4f7f\u7528\u4ece\u4f53\u5916\u63d0\u4f9b\u7684\u805a\u7126\u8d85\u58f0\uff0c\u901a\u8fc7\u7a7a\u5316\u673a\u68b0\u7834\u574f\u7ec4\u7ec7\uff0c\u4f7f\u9776\u6807\u53d8\u6210\u8131\u7ec6\u80de\u788e\u7247\u3002Histotripsy\u6d88\u878d\u533a\u7684\u6750\u6599\u57281-2\u4e2a\u6708\u5185\u88ab\u8eab\u4f53\u5438\u6536\uff0c\u7559\u4e0b\u6700\u5c0f\u7684\u6b8b\u7559\u75a4\u75d5\u3002<\/p>\n
\u5176\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u88ab\u8bc1\u660e\u53ef\u4ee5\u523a\u6fc0\u514d\u75ab\u53cd\u5e94\u5e76\u8bf1\u5bfc\u8fdc\u9694\u6548\u5e94\uff0c\u8fd9\u53ef\u80fd\u5bf9\u672a\u6765\u7684\u764c\u75c7\u6cbb\u7597\u4ea7\u751f\u79ef\u6781\u5f71\u54cd\u3002<\/p>\n
Histotripsy\u5df2\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u88ab\u5e7f\u6cdb\u7814\u7a76\uff0c\u5305\u62ec\u6cbb\u7597\u764c\u75c7\u3001\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u3002\u5df2\u7ecf\u8fdb\u884c\u4e86\u4e09\u9879\u4f7f\u7528Histotripsy\u6cbb\u7597\u826f\u6027\u524d\u5217\u817a\u589e\u751f\u3001\u809d\u764c\u548c\u9499\u5316\u74e3\u819c\u72ed\u7a84\u7684\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n
Histotripsy\u6a21\u62df\u624b\u672f\u73b0\u573a\uff0c\u56fe\u6e90\u81ea\u9999\u6e2f\u5546\u62a5\u7f51<\/p>\n
\uff08\u4e00\uff09\u7ec4\u7ec7\u7834\u88c2\u672f<\/p>\n
\u201c\u7ec4\u7ec7\u788e\u88c2\u672f\u201d\u4e00\u8bcd\u4e8e2004\u5e74\u5728\u5bc6\u6b47\u6839\u5927\u5b66\u521b\u9020\u3002\u5728\u5e0c\u814a\u8bed\u4e2d\uff0c\u201cHisto\u201d\u7684\u610f\u601d\u662f\u201c\u8f6f\u7ec4\u7ec7\u201d\uff0c\u800c\u201ctripsy\u201d\u6307\u7684\u662f\u5206\u89e3\u3002\u4e0e\u70edHIFU\u76f8\u6bd4\uff0c\u70edHIFU\u4f7f\u7528\u4e2d\u7b49\u9ad8\u5f3a\u5ea6\u548c\u9ad8\u5360\u7a7a\u6bd4\uff08\u8d85\u58f0\u5bfc\u901a\u65f6\u95f4\/\u603b\u6cbb\u7597\u65f6\u95f4\u226510%\uff09\u7684\u8fde\u7eed\u6216\u957f\u65f6\u95f4\u8d85\u58f0\u7206\u53d1\u6765\u52a0\u70ed\u7ec4\u7ec7\uff0cHistotripsy\u4f7f\u7528\u4f4e\u5360\u7a7a\u6bd4\u22641%\u7684\u77ed\u8d85\u58f0\u7206\u53d1\uff08\u5fae\u79d2\u957f\u5ea6\uff09\u6765\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u52a0\u70ed\uff0c\u5e76\u4f7f\u7528\u66f4\u9ad8\u7684\u5cf0\u503c\u538b\u529b\u5e45\u5ea6\u4ece\u7ec4\u7ec7\u4e2d\u7684\u5185\u6e90\u6027\u6c14\u4f53\u4ea7\u751f\u58f0\u7a7a\u5316\u3002<\/p>\n
\u58f0\u7a7a\u5316\u662f\u7531\u8d85\u58f0\u6fc0\u6d3b\u7684\u5fae\u6c14\u6ce1\u7684\u4ea7\u751f\u3001\u632f\u8361\u548c\u5d29\u6e83\u3002\u975e\u5e38\u9ad8\u7684\u8d85\u58f0\u538b\u529b\u4f1a\u5bfc\u81f4\u7a7a\u5316\u6c14\u6ce1\u7684\u60ef\u6027\u81a8\u80c0\u548c\u5d29\u6e83\uff0c\u4ece\u800c\u4ea7\u751f\u5c40\u90e8\u5f3a\u70c8\u7684\u5e94\u53d8\uff0c\u4f7f\u7ec6\u80de\u7834\u88c2\u6210\u8131\u7ec6\u80de\u788e\u7247\u3002\u8d85\u58f0\u6210\u50cf\u53ef\u7528\u4e8e\u5b9e\u65f6\u6307\u5bfc\u548c\u76d1\u6d4b\u7ec4\u7ec7\u5207\u5f00\u672f\u7a0b\u5e8f\u3002\u4e0e\u8bb8\u591a\u73b0\u6709\u7684\u5fae\u521b\u6280\u672f\u76f8\u6bd4\uff0cHistotripsy\u53ef\u4ee5\u65e0\u521b\u5730\u5207\u9664\u7ec4\u7ec7\u3002<\/p>\n
\u5176\u539f\u7406\u662f\uff0c\u5f53\u7ec4\u7ec7-\u6db2\u754c\u9762\uff08\u5982\u8840\u51dd\u5757\u6216\u5fc3\u810f\u7ec4\u7ec7\uff09\u8fdb\u884c\u7ec4\u7ec7-\u6db2\u4f53\u5207\u5272\u65f6\uff0c\u7ec4\u7ec7\u4ece\u8868\u9762\u5411\u5185\u4fb5\u8680\uff0c\u5f62\u6210\u8fb9\u754c\u6e05\u6670\u7684\u7a7f\u5b54\u3002\u5f53\u9488\u5bf9\u5927\u5757\u7ec4\u7ec7\uff08\u4f8b\u5982\u80bf\u7624\uff09\u5185\u7684\u7ec4\u7ec7\u788e\u77f3\u65f6\uff0cHistotripsy\u5c06\u9776\u7ec4\u7ec7\u6db2\u5316\u4e3a\u8131\u7ec6\u80de\u5300\u6d46\uff0c\u788e\u7247\u57281-2\u4e2a\u6708\u5185\u88ab\u8eab\u4f53\u5438\u6536\uff0c\u7559\u4e0b\u5c0f\u75a4\u75d5\u3002<\/p>\n
\u5728Histotripsy\u53d1\u660e\u4e4b\u524d\uff0c\u5df2\u77e5\u70edHIFU\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u7a7a\u5316\u4f1a\u5bf9\u7ec4\u7ec7\u9020\u6210\u7ed3\u6784\u6027\u673a\u68b0\u635f\u4f24\u3002\u788e\u77f3\u672f\u4e2d\u4e5f\u89c2\u5bdf\u5230\u8f6f\u7ec4\u7ec7\u7a7a\u5316\u635f\u4f24\uff0c\u5c24\u5176\u662f\u5728\u4f7f\u7528\u9ad8\u8109\u51b2\u91cd\u590d\u9891\u7387\u65f6\u3002<\/p>\n
\u7ec4\u7ec7\u5207\u9664\u672f\u5df2\u7528\u4e8e\u8bb8\u591a\u4e34\u5e8a\u524d\u5e94\u7528\uff0c\u5305\u62ec\u6cbb\u7597\u809d\u810f\u80bf\u7624\u3001\u80be\u810f\u548c\u524d\u5217\u817a\u80bf\u7624\u3001\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u3001\u8840\u6813\u5f62\u6210\u3001\u8840\u80bf\u3001\u65b0\u751f\u513f\u548c\u80ce\u513f\u5148\u5929\u6027\u5fc3\u810f\u75c5\u3001\u74e3\u819c\u75be\u75c5\u3001\u80be\u7ed3\u77f3\u3001\u8113\u80bf\u3001\u808c\u8171\u548c\u751f\u7269\u819c\u3002<\/p>\n<\/p>\n
\u673a\u5236<\/p>\n
\u6784\u6210Histotripsy\u57fa\u7840\u7684\u5173\u952e\u673a\u5236\u662f\u58f0\u7a7a\u5316\u7684\u53ef\u63a7\u4ea7\u751f\u4ee5\u53ca\u7a7a\u5316\u4e0e\u7ec4\u7ec7\u4e4b\u95f4\u7684\u76f8\u4e92\/\u4f5c\u7528\uff0c\u8fd9\u5bfc\u81f4\u7ec4\u7ec7\u5206\u89e3\u3002\u6a21\u62df\u548c\u5b9e\u9a8c\u8bc1\u636e\u8868\u660e\uff0c\u7eb3\u7c73\u7ea7\u6c14\u7a74\u5b58\u5728\u4e8e\u7ec4\u7ec7\u4e2d\uff0c\u53ef\u4ee5\u8d77\u5230\u7a7a\u5316\u6838\u7684\u4f5c\u7528\u3002<\/p>\n
\u5f53\u5fae\u79d2\u7ea7\u957f\u5ea6\u7684\u8109\u51b2\u8fbe\u5230\u8d85\u8fc7\u56fa\u6709\u9608\u503c\u7684\u8d1f\u538b\u5e76\u514b\u670d\u73b0\u6709\u7eb3\u7c73\u6c14\u7a74\u7684\u8868\u9762\u5f20\u529b\u65f6\uff0c\u5c31\u4f1a\u5728\u7ec4\u7ec7\u5207\u7247\u672f\u4e2d\u4ea7\u751f\u7a7a\u5316\u3002\u5728\u79bb\u4f53\u5b9e\u9a8c\u4e2d\u6d4b\u91cf\u5230\uff0c\u5bf9\u4e8e\u6c34\u57fa\u7ec4\u7ec7\uff0c\u5982\u8840\u6813\u3001\u809d\u810f\u3001\u80be\u810f\u3001\u5fc3\u810f\u3001\u5927\u8111\u3001\u813e\u810f\u3001\u80f0\u817a\u4ee5\u53ca\u8840\u6db2\u548c\u6c34\uff0c\u8be5\u9608\u503c\u4e3a26-30MPa\u3002\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u8be5\u538b\u529b\u9608\u503c\u5bf9\u5e94\u4e8e\u76f4\u5f84\u4e3a2-5nm\u7684\u6c14\u7a74\u7684\u8868\u9762\u5f20\u529b\u3002\u56fa\u6709\u9608\u503c\u4ec5\u968f\u9891\u7387\u7565\u6709\u53d8\u5316\u3002<\/p>\n
Histotripsy\u901a\u5e38\u4f7f\u7528\u5fae\u79d2\u7ea7\u957f\u5ea6\u7684\u8d85\u58f0\u8109\u51b2\uff0c\u7a81\u53d1\u6301\u7eed\u65f6\u95f4\u226410\u4e2a\u58f0\u5b66\u5468\u671f\u6765\u4ea7\u751f\u4e00\u7c07\u5fae\u6ce1\uff08\u7a7a\u5316\u6c14\u6ce1\u4e91\uff09\u3002<\/p>\n
\u7a7a\u5316\u5fae\u6ce1\u88ab\u8ba4\u4e3a\u901a\u5e38\u5728\u7ec6\u80de\u5916\u57fa\u8d28\u4e2d\u4ea7\u751f\u3002\u6c14\u6ce1\u4ece2-5nm\u751f\u957f\u5230>100\u03bcm\uff0c\u7136\u540e\u5728\u51e0\u767e\u5fae\u79d2\u5185\u9ad8\u80fd\u574d\u7f29\u3002\u5fae\u6ce1\u7684\u8fd9\u79cd\u5feb\u901f\u81a8\u80c0\u548c\u5d29\u6e83\u5bf9\u7d27\u90bb\u7684\u7ec6\u80de\u4ea7\u751f\u975e\u5e38\u9ad8\u7684\u5e94\u53d8\u548c\u5e94\u529b\uff0c\u5bfc\u81f4\u7cbe\u786e\u7684\u673a\u68b0\u7834\u574f\uff0c\u6709\u65f6\u751a\u81f3\u53ef\u4ee5\u5728\u6d88\u878d\u8fb9\u754c\u5904\u5c06\u7ec6\u80de\u4e00\u5206\u4e3a\u4e8c\u3002\u9776\u6807\u5185\u7684\u7ec6\u80de\u5b8c\u5168\u7834\u574f\u4e0d\u662f\u7531\u4e00\u4e2a\u8109\u51b2\u53d1\u751f\u7684\uff0c\u9700\u8981\u591a\u4e2a\u8109\u51b2\u4ea7\u751f\u7684\u5faa\u73af\u5e94\u53d8\u3002<\/p>\n
\u56fe 1 \u7531 \uff08A\uff09\u5185\u7980\u9608\u503c\u7ec4Histotripsy\u548c \uff08B\uff09 \u6fc0\u6ce2\u6563\u5c04\u7ec4\u7ec7\u5207\u7247\u672f\u4ea7\u751f\u7684\u7a7a\u5316\u7684\u9ad8\u901f\u7167\u7247\u3002\u8d85\u58f0\u6ce2\u4ece\u5de6\u5411\u53f3\u4f20\u64ad\u3002<\/p>\n
\uff08\u4e00\uff09\u9776\u5411\u5927\u5757\u7ec4\u7ec7<\/p>\n
\u5f53\u9776\u5411\u5927\u5757\u7ec4\u7ec7\u4f53\u79ef\u65f6\uff0c\u7ec4\u7ec7\u788e\u77f3\u53ef\u4ee5\u5b8c\u5168\u7834\u574f\u76ee\u6807\u7ec4\u7ec7\uff0c\u5b9e\u73b0\u6db2\u4f53\u7a20\u5ea6\u5300\u6d46\uff0c\u800c\u6ca1\u6709\u5b8c\u6574\u7ec6\u80de \uff08\u56fe 2\uff08A\uff09\uff09\u3002\u7ecf\u7ec4\u7ec7\u788e\u77f3\u5904\u7406\u7684\u7ec4\u7ec7\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c \uff08TEM\uff09 \u663e\u5fae\u7167\u7247\u663e\u793a\uff0c\u5728\u5904\u7406\u533a\u57df\u5185\u51e0\u4e4e\u6ca1\u6709\u660e\u663e\u7684\u4e9a\u7ec6\u80de\u7ed3\u6784\u3002\u5728\u4f53\u5185\u75c5\u4f8b\u4e2d\uff0c\u5904\u7406\u533a\u7684\u8131\u7ec6\u80de\u788e\u7247\u4e0e\u7ea2\u7ec6\u80de\u548c\u7ea2\u7ec6\u80de\u788e\u7247\u6df7\u5408\u3002\u8131\u7ec6\u80de\u788e\u7247\u5728 ~1-2\u4e2a\u6708\u5185\u88ab\u8eab\u4f53\u5438\u6536\uff0c\u53ea\u7559\u4e0b\u4e00\u5c0f\u5757\u7ea4\u7ef4\u75a4\u75d5\uff08\u56fe 2\uff08B\\D\uff09\uff09 \u3002<\/p>\n
\u56fe 2<\/p>\n
\uff08A\uff09\u7ecfHistotripsy\u5904\u7406\u7684\u79bb\u4f53\u732a\u5fc3\u810f\u7ec4\u7ec7\u7684 H&E \u8f7d\u73bb\u7247\u663e\u793a\u6cbb\u7597\u533a\u57df\u5185\u6ca1\u6709\u5b8c\u6574\u7684\u7ec6\u80de\uff0c\u5e76\u4e14\u5728\u5c16\u9510\u75c5\u53d8\u8fb9\u754c\u5904\u7ec6\u80de\u88ab\u4e00\u5206\u4e3a\u4e8c\u3002\uff08B-C\uff09\u7ecf\u7ec4\u7ec7\u5207\u9664\u672f\u6cbb\u7597\u7684\u5927\u9f20\u809d\u810f\u7684\u5927\u4f53\u5f62\u6001\u663e\u793a\uff0c\u6cbb\u7597\u540e \uff08B\uff09\u5728\u7ec4\u7ec7\u5207\u9664\u672f\u6cbb\u7597\u533a\u5185\u51fa\u73b0\u6df1\u8272\u8840\u80bf\uff0c\u7b2c28\u5929 \uff08C\uff09\u53ea\u6709\u4e00\u4e2a\u5c0f\u7684\u6536\u7f29\u75a4\u75d5\u3002\uff08D\uff09\u7ecf\u7ec4\u7ec7\u5207\u9664\u672f\u6cbb\u7597\u7684\u5927\u9f20\u809d\u810f\u7684\u7ec4\u7ec7\u5b66\u663e\u793a\u7b2c28\u5929\u6b8b\u7559\u75a4\u75d5\u548c\u5f02\u7269\u5de8\u7ec6\u80de\uff08GC\uff09 \u7684\u5c0f\u75c5\u7076\uff0c\u4f34\u6709\u9499\u5316\u7684\u672a\u6d88\u5316\u788e\u7247\u3002\uff08E\uff09\u7ec4\u7ec7\u5207\u9664\u672f\u901a\u8fc7\u4e00\u5757\u79bb\u4f53\u732a\u5fc3\u623f\u58c1\u4ea7\u751f\u7a7f\u5b54\u3002<\/p>\n
\uff08\u4e8c\uff09\u5728\u7ec4\u7ec7-\u6db2\u4f53\u754c\u9762\u5904<\/p>\n
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\u8fd9\u79cd\u5dee\u5f02\u9608\u503c\u5bfc\u81f4\u5728Histotripsy\u4e2d\u89c2\u5bdf\u5230\u7684\u7ec4\u7ec7\u9009\u62e9\u6027\u5242\u91cf\u76f8\u5173\u6d88\u878d\u73b0\u8c61 \u3002\u4f8b\u5982\uff0c\u5728\u6cbb\u7597\u809d\u810f\u65f6\uff0c\u7ec6\u80de\u53ef\u4ee5\u88ab\u5b8c\u5168\u7834\u574f\uff0c\u800c\u6d88\u878d\u533a\u5185\u7684\u80c6\u7ba1\u3001\u8f83\u5927\u7684\u8840\u7ba1\u3001\u795e\u7ecf\u548c\u7ed3\u7f14\u7ec4\u7ec7\u4fdd\u6301\u5b8c\u6574\u3002\u56fe 3) \u3002\u6cbb\u7597\u80be\u810f\u65f6\uff0c\u80be\u76ae\u8d28\u7ec4\u7ec7\u53ef\u5b8c\u5168\u6db2\u5316\uff0c\u800c\u96c6\u5408\u7cfb\u7edf\u7ed3\u6784\u4fdd\u6301\u5b8c\u6574\u3002<\/p>\n
\u56fe 3<\/p>\n
\uff08A\uff09 \u7ecfHistotripsy\u5904\u7406\u7684\u4f53\u5185\u732a\u809d\u5185\u7684\u5927\u8840\u7ba1\u4fdd\u6301\u5b8c\u6574\u5e76\u88ab\u65e0\u7ec6\u80de\u788e\u7247\u5305\u56f4\u3002\uff08B\uff09 \u5bf9\u6bd4\u589e\u5f3a MR \u56fe\u50cf\u663e\u793a\u6df1\u8272\u7ec4\u7ec7\u788e\u77f3\u6cbb\u7597\u533a\u5185\u7684\u80c6\u7ba1\u672a\u95ed\uff08\u84dd\u8272\u7bad\u5934\uff09\u3002<\/p>\n
\uff08\u4e09\uff09\u6cb8\u817eHistotripsy<\/p>\n
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\u56fe\u50cf\u5f15\u5bfc<\/p>\n
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\u56fe 4\uff08A\uff09Histotripsy\u672f\u4ea7\u751f\u7684\u7a7a\u5316\u5728 B \u578b\u8d85\u58f0\u4e0a\u88ab\u89c6\u4e3a\u9ad8\u56de\u58f0\u533a\u3002\uff08B\uff09 \u201cM\u201d \u5f62Histotripsy\u75c5\u53d8\u5728 B \u578b\u8d85\u58f0\u56fe\u50cf\u4e0a\u663e\u793a\u4e3a\u4f4e\u56de\u58f0\u533a\u3002\uff08C\uff09 \u5728\u8fd9\u5f20 T1 \u52a0\u6743\u5bf9\u6bd4\u589e\u5f3a MR \u56fe\u50cf\u4e0a\uff0cHistotripsy\u6d88\u878d\u533a\u88ab\u89c6\u4e3a\u4f4e\u4fe1\u53f7\uff08\u975e\u589e\u5f3a\uff09\u533a\u57df\u3002<\/p>\n
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\u8d85\u58f0\u6210\u50cf\u5f15\u5bfc\u4e3b\u8981\u6709\u4e24\u4e2a\u5c40\u9650\u6027\u3002\u9996\u5148\uff0c\u67d0\u4e9b\u80bf\u7624\u53ef\u4ee5\u5728 MRI \u6216CT\u4e0a\u6e05\u695a\u5730\u770b\u5230\uff0c\u4f46\u5728\u8d85\u58f0\u4e0a\u770b\u4e0d\u5230\u2014\u2014\u901a\u5e38\u662f\u7531\u4e8e\u8bca\u65ad\u6027\u8d85\u58f0\u7a97\u53e3\u4e0d\u8db3\u3002\u5728\u8fd9\u4e9b\u60c5\u51b5\u4e0b\uff0c\u53ef\u4ee5\u5c06\u8d85\u58f0\u56fe\u50cf\u4e0e\u6cbb\u7597\u524dMRI\u6216CT\u626b\u63cf\u5171\u540c\u914d\u51c6\u548c\/\u6216\u5f15\u4fe1\uff0c\u4ee5\u63d0\u9ad8\u9776\u5411\u7cbe\u5ea6\u3002\u5176\u6b21\uff0c2D\u8d85\u58f0\u5728\u6cbb\u7597\u671f\u95f4\u65e0\u6cd5\u63d0\u4f9b3D\u4f53\u79ef\u6210\u50cf\u3002\u7136\u800c\uff0c2D\u8d85\u58f0\u6210\u50cf\u7528\u4e8eHistotripsy\u5f15\u5bfc\uff0c\u56e0\u4e3a3D\u8d85\u58f0\u6210\u50cf\u63a2\u5934\u7684\u5360\u5730\u9762\u79ef\u8981\u5927\u5f97\u591a\uff0c\u53d6\u4ee3\u4e86Histotripsy\u6cbb\u7597\u6362\u80fd\u5668\u6240\u9700\u7684\u4e00\u4e9b\u58f0\u7a97\u7a7a\u95f4\u3002<\/p>\n
\uff08\u4e8c\uff09\u6838\u78c1\u5171\u632f\u6210\u50cf<\/p>\n
MRI \u53ef\u7528\u4e8e\u8bc4\u4f30\u7ec4\u7ec7\u788e\u77f3\u6cbb\u7597\u540e\u7684\u6548\u679c\u3002\u5728T1\u52a0\u6743\u3001T2\u52a0\u6743\u548c\u9020\u5f71\u5242\u589e\u5f3a MR \u56fe\u50cf\u4e0a\u6e05\u6670\u53ef\u89c1\u7ec4\u7ec7\u788e\u77f3\u6d88\u878d\u533a\u3002\u5728 T1 \u52a0\u6743\u56fe\u50cf\u4e0a\uff0c\u7531\u4e8e\u8840\u6ede\u7559\uff0c\u6d88\u878d\u533a\u5448\u9ad8\u4fe1\u53f7\u3002\u9020\u5f71\u540e\uff0c\u6d88\u878d\u533a\u6ca1\u6709\u589e\u5f3a\uff0c\u4ece\u800c\u53ef\u4ee5\u533a\u5206\u6d88\u878d\u533a\u548c\u6b8b\u7559\u80bf\u7624 (\u56fe 4\uff08C\uff09)\u3002<\/p>\n
\u5bf9\u4e8e\u7a0b\u5e8f\u6210\u50cf\uff0cMRI \u4e0a\u53ef\u4ee5\u770b\u5230\u7ec4\u7ec7\u6574\u7406\u672f\u8bf1\u5bfc\u7684\u7a7a\u5316\uff0c\u7279\u6b8a\u7684\u8109\u51b2\u5e8f\u5217\u4e0e\u8d85\u58f0\u8109\u51b2\u540c\u6b65\uff0c\u589e\u52a0\u4e86\u672a\u6765\u5b9e\u65f6\u76d1\u6d4b\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<\/p>\n
\u4e34\u5e8a\u7814\u7a76\u53ca\u5e94\u7528\u60c5\u51b5<\/p>\n
2023\u5e7410\u6708\uff0cFDA\u6279\u51c6HistoSonics\u00ae \u5f00\u53d1\u7684\u65e0\u521b Edison\u00ae \u7cfb\u7edf\u4f7f\u7528\u58f0\u6ce2\u6765\u7834\u574f\u809d\u810f\u80bf\u7624\u3002FDA\u7684\u6388\u6743\u90e8\u5206\u662f\u57fa\u4e8e\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u768413\u4e2a\u5730\u70b9\u8fdb\u884c\u7684 #HOPE4LIVER \u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86Edison\u7cfb\u7edf\u6cbb\u7597\u539f\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u809d\u80bf\u7624\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n
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\u572844\u4f8b\u63a5\u53d7\u6cbb\u7597\u7684\u80bf\u7624\u4e2d\uff0c\u670942\u4f8b \uff0895%;95% CI\uff1a84\uff0c100\uff09 \u89c2\u5bdf\u5230\u6280\u672f\u6210\u529f\uff0c44\u4f8b\u53c2\u4e0e\u8005\u4e2d\u67093\u4f8b \uff087%;95% CI\uff1a2\uff0c18\uff09 \u62a5\u544a\u4e86\u4e0e\u624b\u672f\u76f8\u5173\u7684\u4e25\u91cd\u5e76\u53d1\u75c7\uff0c\u5747\u8fbe\u5230\u4e86\u6027\u80fd\u76ee\u6807\u3002<\/p>\n
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2016-2017\u5e74\u5728\u7f8e\u56fd\u4e24\u5bb6\u533b\u7597\u4e2d\u5fc3\u8fdb\u884c\u7684I\u671f\u5b89\u5168\u6027\u8bd5\u9a8c\uff08NCT01896973\uff09\u4e2d\uff0cHistoSonics\uff08\u5bc6\u6b47\u6839\u5dde\u5b89\u5a1c\u5821\uff09\u5236\u9020\u7684\u4e34\u5e8a\u539f\u578b\u524d\u5217\u817aHistotripsy\u88c5\u7f6e\uff08Vortx Rx\uff09\u7528\u4e8e\u6cbb\u759725\u4f8bBPH\u60a3\u8005\uff0c\u5176\u4e2d\u524d\u5217\u817a\u80a5\u5927\u4f1a\u6536\u7f29\u5c3f\u9053\u5e76\u5bfc\u81f4\u6392\u5c3f\u56f0\u96be\u3002\u672a\u89c2\u5bdf\u5230\u4e25\u91cd\u7684\u672f\u4e2d\u4e0d\u826f\u4e8b\u4ef6\u300268%\u7684\u53d7\u8bd5\u8005\u63a5\u53d7\u4e86\u5168\u8eab\u9ebb\u9189\uff0c\u800c 32% \u7684\u53d7\u8bd5\u8005\u63a5\u53d7\u4e86\u9547\u9759\u6cbb\u7597\u3002\u6240\u6709\u53d7\u8bd5\u8005\u901a\u8fc7\u7ecf\u76f4\u80a0\u8d85\u58f0\u6210\u50cf\u89c2\u5bdf\u5230\u7a7a\u6d1e\u7684\u4ea7\u751f\uff0c\u4f46\u672a\u89c2\u5bdf\u5230\u7ec4\u7ec7\u7834\u574f\u3002<\/p>\n
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\u8be5\u8bd5\u9a8c\u5728\u4eba\u7c7b\u4e2d\u8bc1\u660e\u4e86\u521d\u6b65\u5b89\u5168\u6027\uff0c\u4f46\u9700\u8981\u6539\u8fdb\u8bbe\u5907\u548c\/\u6216\u53c2\u6570\u4ee5\u8bc1\u660e\u5bf9\u524d\u5217\u817a\u7ec4\u7ec7\u788e\u77f3\u7ec4\u7ec7\u7834\u574f\u7684\u7597\u6548\u3002<\/p>\n
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2019 \u5e74\u5728\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3\u8fdb\u884c\u4e86\u591a\u7076\u6027\u809d\u6076\u6027\u80bf\u7624\u975e\u6cbb\u6108\u6027\u809dHistotripsy\u7684\u9996\u6b21 I \u671f\u4eba\u4f53\u8bd5\u9a8c \uff08NCT03741088\uff09\u3002<\/p>\n
\u4f7f\u7528\u4e86 Histosonics\uff0cInc.\uff08\u5bc6\u6b47\u6839\u5dde\u5b89\u5a1c\u5821\uff09\u5236\u9020\u7684\u4e34\u5e8a\u539f\u578b\u809d\u7ec4\u7ec7\u788e\u77f3\u88c5\u7f6e\u300211 \u4f8b\u80bf\u7624\uff08\u8303\u56f4 0.5-2.1cm\uff09\u9776\u54118\u4f8b\u60a3\u8005\uff0c\u5305\u62ec1\u4f8b\u809d\u7ec6\u80de\u764c \uff08HCC\uff09 \u548c 10 \u4f8b\u809d\u810f\u8f6c\u79fb\uff08\u7ed3\u76f4\u80a0\u764c\u3001\u4e73\u817a\u764c\u548c\u80c6\u56ca\u764c\uff09\u3002\u672a\u53d1\u751f\u4e0e\u624b\u672f\u76f8\u5173\u7684\u91cd\u5927\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8bc1\u660e\u4e86\u809d\u810f\u7ec4\u7ec7\u5207\u9664\u672f\u7684\u65e9\u671f\u5b89\u5168\u6027\u3002\u6240\u6709\u7a0b\u5e8f\u90fd\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u5373\u5728\u624b\u672f\u540e 1 \u5929\u901a\u8fc7 MRI \u8bc4\u4f30\u6bcf\u4e2a\u8ba1\u5212\u521b\u5efa\u6d88\u878d\u672f\u3002<\/p>\n
\u7531\u4e8e\u8bca\u65ad\u8d85\u58f0\u6210\u50cf\u7684\u5c40\u9650\u6027\uff0c\u5355\u4e2a5mm \u80bf\u7624\u88ab\u8bef\u5b9a\u4f4d\uff0c\u800c\u5728\u6240\u6709\u5176\u4ed6\u80bf\u7624\u4e2d\uff0c\u5728 2 \u4e2a\u6708\u65f6\u901a\u8fc7 MRI \u89c2\u5bdf\u5230\u5c40\u90e8\u80bf\u7624\u6d88\u9000\u3002\u901a\u8fc7 T1 \u52a0\u6743\u5bf9\u6bd4MRI\u6d4b\u91cf\uff0c\u6d88\u878d\u533a\u7684\u4f53\u79ef\u6536\u7f29\u57281\u5468\u65f6\u5e73\u5747\u4e3a 36.0%\uff0c\u5728 1 \u4e2a\u6708\u65f6\u4e3a 53.6%\uff0c\u5728 2\u4e2a\u6708\u65f6\u4e3a 71.8%\u30022 \u4f8b\u60a3\u8005 \uff082\/8\uff0c 25%\uff09\uff0cHCC \u548c\u7ed3\u76f4\u80a0\u764c \uff08CRC\uff09 \u54041\u4f8b\uff0c\u672f\u540e\u80bf\u7624\u6807\u5fd7\u7269\u6301\u7eed\u4e0b\u964d\uff0cCRC \u60a3\u8005\u672f\u540e 8 \u5468\u975e\u9776\u6027\u80bf\u7624\u7f29\u5c0f\u3002\u8be5I\u671f\u8bd5\u9a8c\u8bc1\u660e\u4e86\u809d\u810fHistotripsy\u7684\u521d\u6b65\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5e76\u63d0\u4f9b\u4e86Histotripsy\u5728\u4eba\u7c7b\u4e2d\u8bf1\u5bfc\u6f5c\u5728\u8fdc\u9694\u6548\u5e94\u7684\u7b2c\u4e00\u4e2a\u8bc1\u636e\u3002<\/p>\n
Histotripsy\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u5728\u4f53\u5185\u4eba\u732a\u6b63\u5e38\u809d\u810f\u4e2d\u4ea7\u751f\u6709\u6548\u3001\u5b89\u5168\u7684\u6d88\u878d\u672f\u3002\u5728 20-75 \u5206\u949f\u5185\uff0c\u901a\u8fc73-12cm\u7684\u4e0a\u8986\u7ec4\u7ec7\u5c0612-60ml \u7684\u76ee\u6807\u809d\u810f\u4f53\u79ef\u5b8c\u5168\u6d88\u878d\uff08\u56fe 5\uff08A–D\uff09\uff09.\u5728\u6d88\u878d\u533a\u57df\u5185\uff0c\u5b9e\u73b0\u4e86\u5747\u5300\u7684\u7ec4\u7ec7\u7834\u574f\uff0c\u6ca1\u6709\u5b8c\u6574\u7684\u7ec6\u80de\u6b8b\u7559\uff0c\u800c\u4e3b\u8981\u8840\u7ba1\u548c\u80c6\u7ba1\u5b8c\u597d\u65e0\u635f\u3002<\/p>\n
\u56fe5 \u4f53\u5185\u732a\u809d\u7684Histotripsy\u6cbb\u7597\u3002<\/p>\n
\u8f74\u5411T2\u52a0\u6743MR\u56fe\u50cf \uff08A\uff09\u548c\u5927\u4f53\u5f62\u6001 \uff08B\uff09 \u663e\u793a\u7403\u5f62\u6d88\u878d\u4f53\u79ef\u3002<\/p>\n
\uff08C\uff09\u6d88\u878d\u533a\u4e2d\u5fc3 \uff08100X\uff09\u7684H&E\u73bb\u7247\u663e\u793a\u6ca1\u6709\u6d3b\u7684\u809d\u7ec6\u80de\u3002<\/p>\n
\uff08D\uff09\u6d88\u878d\u5916\u56f4\u7684H&E\u73bb\u7247 \uff08100X\uff09 \u663e\u793a\u6d3b\u809d<\/p>\n
\uff08L\uff09\u574f\u6b7b\u809d\uff08N\uff09\u548c\u8fc7\u6e21\u533a\u8584\uff08Z\uff09\u3002<\/p>\n
\uff08E-G\uff09\u556e\u9f7f\u52a8\u7269 HCC \u6a21\u578b\u4e2d\u90e8\u5206\u7ec4\u7ec7\u5207\u9664\u672f\u6cbb\u7597\u7684MR\u56fe\u50cf\u3002<\/p>\n
\uff08E\uff09T2\u52a0\u6743MRI\u4e0a\u539f\u59cb\u672a\u6cbb\u7597\u7684\u80bf\u7624\u5916\u89c2\u4e3a\u9ad8\u4fe1\u53f7\uff08\u9ec4\u8272\u7bad\u5934\uff09\u3002<\/p>\n
\uff08F\uff09 \u7ec4\u7ec7\u5207\u9664\u672f\u540e\uff0c\u6d88\u878d\u533a\u663e\u793aT2\u4f4e\u4fe1\u53f7\uff08\u7ea2\u8272\u865a\u7ebf\uff09\u3002<\/p>\n
\uff08G\uff09\u572812\u5468\u65f6\uff0cMRI\u5728\u539f\u59cb\u80bf\u7624\u90e8\u4f4d\u4ec5\u53ef\u68c0\u6d4b\u5230a~5mm\u7684\u975e\u80bf\u7624\u7ea4\u7ef4\u7ec4\u7ec7\u533a\uff0c\u8868\u660e\u6d88\u878d\u533a\u548c\u80bf\u7624\u51e0\u4e4e\u5b8c\u5168\u6d88\u9000\u3002<\/p>\n
\uff08H-I\uff09\u7ec4\u7ec7\u5207\u9664\u672f\u8bf1\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\u548c\u8fdc\u9694\u6548\u5e94\u3002<\/p>\n
\uff08H\uff09\u7ec4\u7ec7\u6574\u7406\u672f\u6d88\u878d\uff08HT ablated\uff09 \u548c\u5bf9\u4fa7\u975e\u6d88\u878d\u80bf\u7624\uff08HT abscopal\uff09\u7684FACS\u5206\u6790\u786e\u5b9a\u4e86\u7624\u5185 CD8T\u7ec6\u80de\u6d78\u6da6\u7684\u76f8\u5f53\u6c34\u5e73\uff0c\u663e\u8457\u9ad8\u4e8e\u672a\u7ecf\u6cbb\u7597\u7684\u5bf9\u7167\u80bf\u7624\u3002<\/p>\n
\uff08I\uff09\u5728\u5927\u4f53\u68c0\u67e5\u65f6\uff0c\u4e0e\u672a\u6cbb\u7597\u7684\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u63a5\u53d7\u7ec4\u7ec7\u5207\u9664\u672f\u6cbb\u7597\u7684\u5c0f\u9f20\u7684\u80ba\u8f6c\u79fb\u51cf\u5c11\u3002<\/p>\n
\u7531\u4e8e\u9aa8\u9abc\u5bf9\u8d85\u58f0\u4f20\u64ad\u5177\u6709\u9ad8\u5ea6\u53cd\u5c04\u6027\u548c\u5438\u6536\u6027\uff0c\u56e0\u6b64\u7814\u7a76\u4e86\u7ecf\u808b\u9aa8Histotripsy\u7684\u53ef\u884c\u6027\u548c\u5b89\u5168\u6027\u3002\u901a\u8fc7\u9010\u6e10\u589e\u52a0\u8d85\u58f0\u529f\u7387\u76f4\u5230\u5728\u8d85\u58f0\u4e0a\u89c2\u5bdf\u5230\u7a7a\u5316\uff0c\u4f7f\u7528\u7565\u9ad8\u4e8e\u7a7a\u5316\u9608\u503c\u7684\u5c40\u7076\u538b\u529b\u3002\u901a\u8fc7\u5b8c\u5168\u8986\u76d6\u80f8\u8154\u4e0e\u4ec5\u8986\u76d6\u8f6f\u7ec4\u7ec7\u521b\u5efa\u7684\u6d88\u878d\u533a\u5177\u6709\u76f8\u4f3c\u7684\u5c3a\u5bf8\u3002\u5728\u5b8c\u5168\u80f8\u8154\u8986\u76d6\u58f0\u7a97\u7684\u60c5\u51b5\u4e0b\uff0c\u808b\u9aa8\u7684\u6700\u9ad8\u6e29\u5ea6\u5347\u9ad8\u4e3a4.1 \u00b1 1.8\u00b0C\uff0c\u4e0d\u8db3\u4ee5\u5bf9\u808b\u9aa8\u6216\u5468\u56f4\u7ec4\u7ec7\u9020\u6210\u70ed\u635f\u4f24\u3002MRI \u672a\u89c2\u5bdf\u5230\u4f53\u58c1\u635f\u4f24\u3002<\/p>\n
\uff08\u4e09\uff09\u9499\u5316\u4e3b\u52a8\u8109\u74e3\u72ed\u7a84<\/p>\n
\u9499\u5316\u6027\u4e3b\u52a8\u8109\u74e3\u72ed\u7a84\u7684\u65e0\u521b\u8d85\u58f0\u6cbb\u7597\u53ef\u4ee5\u5305\u62ec\u5728\u6574\u4e2a\u7ec4\u7ec7\u5207\u9664\u672f\u5bb6\u65cf\u4e2d\uff0c\u56e0\u4e3a\u5b83\u4f9d\u8d56\u4e8e\u76f8\u4f3c\u7684\u538b\u529b\u8303\u56f4\u548c\u6301\u7eed\u65f6\u95f4\u4e3a\u6570\u5341\u5fae\u79d2\u7684\u8109\u640f\u3002\u7136\u800c\uff0c\u4e0e\u65e8\u5728\u6db2\u5316\u8f6f\u7ec4\u7ec7\u7684\u4f20\u7edfHistotripsy\u76f8\u6bd4\uff0c\u9499\u5316\u74e3\u819c\u7684\u65e0\u521b\u6cbb\u7597\u662f\u57fa\u4e8e\u9499\u5316\u7ec4\u7ec7\u7684\u8f6f\u5316\u4ee5\u6062\u590d\u74e3\u53f6\u7684\u6d3b\u52a8\u6027\u3002\u8be5\u65b9\u6cd5\u7684\u53ef\u884c\u6027\u548c\u5b89\u5168\u6027\u5df2\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u5f97\u5230\u8bc1\u660e\u3002<\/p>\n
2019\u5e74\u5728\u6cd5\u56fd\u548c\u8377\u5170\u4f7f\u7528Cardiawave\u7684Valvosoft\u88c5\u7f6e \uff08NCT03779620\uff09 \u5bf910\u4f8b\u4e25\u91cd\u9499\u5316\u6027\u4e3b\u52a8\u8109\u74e3\u72ed\u7a84\u60a3\u8005\u8fdb\u884c\u4e86\u5fc3\u810fHistotripsy\u7684I\u671f\u4eba\u4f53\u8bd5\u9a8c\u3002\u8fd9\u4e9b\u60a3\u8005\u5e74\u9f84\u8f83\u5927\uff0884.1 \u00b1 6.5\u5c81\uff0c50% \u4e3a\u5973\u6027\uff09\uff0c\u6709\u4e25\u91cd\u7684\u5408\u5e76\u75c7\uff088\u4f8b\u5fc3\u529b\u8870\u7aed\uff0c5\u4f8b\u51a0\u5fc3\u75c5\uff0c5\u4f8b\u80be\u8870\u7aed\uff09\uff0c\u4e0d\u7b26\u5408\u7ecf\u76ae\u4e3b\u52a8\u8109\u74e3\u7f6e\u6362\u672f\u6216\u5fc3\u5185\u76f4\u89c6\u624b\u672f\u7684\u6761\u4ef6\u3002<\/p>\n
\u4f7f\u7528\u5916\u90e8\u591a\u5143\u4ef6\u805a\u7126\u8d85\u58f0\u6362\u80fd\u5668\uff08\u5e26\u5bbd700kHz \u20141.25MHz\uff09\u4ee5100-300 Hz PRF\u30010.25%\u5360\u7a7a\u6bd4\u548c15-20MPa \u5cf0\u503c\u8d1f\u538b\u63d0\u4f9b\u957f\u8fbe60\u5206\u949f\u7684\u7ec4\u7ec7\u788e\u77f3\uff0c\u4ee5\u6cbb\u7597\u548c\u8f6f\u5316\u4e3b\u52a8\u8109\u74e3\u7684\u9499\u5316\u533a\u57df\u3002<\/p>\n
\u672f\u540e1\u4e2a\u6708\uff0c6\u4f8b\u60a3\u8005\u4e3b\u52a8\u8109\u74e3\u9762\u79ef\u5e73\u5747\u589e\u52a0 27.6% \uff08p=0.03\uff09\uff0c\u5e73\u5747\u538b\u529b\u68af\u5ea6\u964d\u4f4e 23.5% \uff08p=0.03\uff09\uff0c\u65e0\u60a3\u8005\u51fa\u73b0\u8111\u8840\u7ba1\u610f\u5916\u3001\u8ba4\u77e5\u529f\u80fd\u6076\u5316\u7b49\u663e\u8457\u4e0d\u826f\u53cd\u5e94\uff0c\u65e0\u6b7b\u4ea1\u53d1\u751f\u3002\u603b\u5171\u67096\u540d\u60a3\u8005\u88ab\u5f52\u7c7b\u4e3a\u53cd\u5e94\u8005\uff0c4\u540d\u88ab\u5f52\u7c7b\u4e3a\u65e0\u53cd\u5e94\u8005\u3002\u5bf9\u4e8e6\u4f8b\u53cd\u5e94\u60a3\u8005\uff0c\u4e0e\u5176\u4ed64\u4f8b\u60a3\u8005\u76f8\u6bd4\uff0c\u65bd\u52a0\u7684\u8d85\u58f0\u80fd\u91cf\u548c\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u66f4\u957f\u30026\u4e2a\u6708\u65f6\uff0c\u53cd\u5e94\u7ec4\u5bf9\u4e3b\u52a8\u8109\u74e3\u533a\u57df\u7684\u6cbb\u7597\u6548\u679c\u4fdd\u6301\u4e0d\u53d8\u3002<\/p>\n
\u57281\u5e74\u968f\u8bbf\u4e2d\uff0c4\u4f8b\u60a3\u8005\u6b7b\u4e8e\u4e0eHistotripsy\u65e0\u5173\u7684\u5fc3\u529b\u8870\u7aed\u8fdb\u5c55\uff0c1\u4f8b\u63a5\u53d7\u4e86\u7ecf\u76ae\u4e3b\u52a8\u8109\u74e3\u7f6e\u6362\u672f\uff0c\u800c\u5176\u4f595\u4f8b\u60a3\u8005\u6ca1\u6709\u4e0e\u624b\u672f\u76f8\u5173\u7684\u91cd\u5927\u4e0d\u826f\u53cd\u5e94\u3002\u8be5\u8bd5\u9a8c\u8868\u660e\u9499\u5316\u6027\u4e3b\u52a8\u8109\u74e3\u72ed\u7a84\u7684\u65e0\u521b\u6cbb\u7597\u662f\u5b89\u5168\u53ef\u884c\u7684\u3002<\/p>\n
\uff08\u56db\uff09\u524d\u5217\u817a\u764c<\/p>\n
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\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n
[1]Xu Z, Hall TL, Vlaisavljevich E, Lee FT Jr. Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound. Int J Hyperthermia. 2021;38(1):561-575. doi: 10.1080\/02656736.2021.1905189. PMID: 33827375; PMCID: PMC9404673.[2]Mendiratta-Lala M, Wiggermann P, Pech M, et al. The# HOPE4LIVER single-arm pivotal trial for histotripsy of primary and metastatic liver tumors[J]. Radiology, 2024, 312(3): e233051.[3]\u300aFDA Paves Way for New Liver Tumor Treatment with Histotripsy\u300bhttps:\/\/\/2024\/02\/13\/fda-paves-way-for-new-liver-tumor-treatment-with-histot[4]\u300a\u6e2f\u5927\u533b\u5b66\u9662\u83b7\u8d60\u4e9a\u6d32\u9996\u90e8\u65e0\u521b\u6cbb\u7597\u809d\u764c\u65b0\u4eea\u5668 \u674e\u5609\u8bda\u7f55\u89c1\u73b0\u8eab\u53d1\u5e03\u4f1a\u300b https:\/\/\/zh-CN\/news\/212628694<\/p>\n
\u4e3b\u7f16\uff5c\u8bb8\u68a6 \u7f16\u8f91\uff5cNicole<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"
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