{"id":45441,"date":"2024-12-25T05:11:08","date_gmt":"2024-12-25T05:11:08","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=45441"},"modified":"2024-12-25T05:11:08","modified_gmt":"2024-12-25T05:11:08","slug":"%e6%a0%87%e5%87%86%e4%b8%8e%e8%a7%84%e8%8c%83-%e6%85%a2%e6%80%a7%e9%85%92%e7%b2%be%e7%9b%b8%e5%85%b3%e6%80%a7%e8%84%91%e6%8d%9f%e5%ae%b3%e7%9a%84%e4%b8%ad%e5%9b%bd%e8%af%8a%e7%96%97%e6%8c%87","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=45441","title":{"rendered":"\u6807\u51c6\u4e0e\u89c4\u8303 | \u6162\u6027\u9152\u7cbe\u76f8\u5173\u6027\u8111\u635f\u5bb3\u7684\u4e2d\u56fd\u8bca\u7597\u6307\u5357\uff082024\uff09"},"content":{"rendered":"

\u5f15\u7528\u672c\u6587\uff1a\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u300a\u9152\u7cbe\u3001\u5417\u5561\u4f9d\u8d56\u5173\u952e\u8bca\u7597\u6280\u672f\u7684\u63a8\u5e7f\u5e94\u7528\u7814\u7a76\u300b\u9879\u76ee\u4e13\u5bb6\u7ec4, \u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u795e\u7ecf\u5185\u79d1\u5206\u4f1a. \u6162\u6027\u9152\u7cbe\u76f8\u5173\u6027\u8111\u635f\u5bb3\u7684\u4e2d\u56fd\u8bca\u7597\u6307\u5357\uff082024\uff09 [J] . \u4e2d\u534e\u533b\u5b66\u6742\u5fd7, 2024, 104(19) : 1663-1679. DOI: 10.3760\/cma.j.cn112137-20230923-00534.<\/p>\n

\u901a\u4fe1\u4f5c\u8005\uff1a\u5f6d\u82f1\uff0c\u4e2d\u5c71\u5927\u5b66\u5b59\u9038\u4ed9\u7eaa\u5ff5\u533b\u9662\u795e\u7ecf\u79d1\uff0c\u5e7f\u5dde 510120\uff0cEmail\uff1apengy2@mail.sysu.edu.cn.<\/p>\n

\u6458\u8981<\/p>\n

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\u6162\u6027\u9152\u7cbe\u76f8\u5173\u6027\u8111\u635f\u5bb3\uff08alcohol-related brain damage\uff0cARBD\uff09\uff0c\u65e2\u5f80\u79f0\u4e3a\u6162\u6027\u9152\u7cbe\u4e2d\u6bd2\u6027\u8111\u75c5\uff08chronic alcoholic encephalopathy\uff0cCAE\uff09\uff0c\u662f\u4e00\u7ec4\u7531\u957f\u671f\u9152\u7cbe\u6444\u5165\u5bfc\u81f4\u4eba\u5927\u8111\u6162\u6027\u635f\u5bb3\u7684\u91cd\u8981\u75be\u75c5\u8c31\u3002\u8fd1\u5e74\u6765\uff0c\u56fd\u5916\u6587\u732e\u4e2d\u591a\u4f7f\u7528ARBD\u6216\u201c\u9152\u7cbe\u76f8\u5173\u6027\u8111\u635f\u4f24\uff08alcohol-related brain injury\uff0cARBI\uff09\u201d\u6765\u6982\u62ec\uff3b1-3\uff3d<\/sup>\uff1b\u7ed3\u5408\u65b0\u7684\u4e34\u5e8a\u8bca\u7597\u5faa\u8bc1\u533b\u5b66\u7814\u7a76\u7ed3\u679c\uff0c\u672c\u6307\u5357\u5728\u300a\u6162\u6027\u9152\u7cbe\u4e2d\u6bd2\u6027\u8111\u75c5\u8bca\u6cbb\u4e2d\u56fd\u4e13\u5bb6\u5171\u8bc6\u300b\u57fa\u7840\u4e0a\u8fdb\u884c\u5faa\u8bc1\u8bc1\u636e\u7684\u66f4\u65b0\u548c\u63a8\u8350\uff3b4\uff3d<\/sup>\uff0c\u5f62\u6210\u6162\u6027ARBD\u7684\u4e2d\u56fd\u8bca\u7597\u6307\u5357\u3002<\/p>\n

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\u4e00\u3001\u6307\u5357\u5236\u8ba2\u65b9\u6cd5\u5b66<\/p>\n

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\u4e8c\u3001\u6162\u6027ARBD\u6982\u8ff0<\/p>\n

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\uff08\u4e8c\uff09\u6162\u6027ARBD\u7684\u4e34\u5e8a\u5206\u7c7b<\/p>\n

\u7ed3\u5408\u75c5\u7406\u8868\u73b0\u4e0e\u4e34\u5e8a\u8868\u73b0\uff0c\u6162\u6027ARBD\u4e3b\u8981\u5206\u4e3a\u4ee5\u4e0b10\u79cd\u7efc\u5408\u5f81\uff3b1-3\uff0c18-19\uff3d<\/sup>\uff1a\u9152\u7cbe\u76f8\u5173\u6027\u8ba4\u77e5\u969c\u788d\uff08alcohol-related cognitive impairment\uff0cARCI\uff09\u3001\u9152\u7cbe\u76f8\u5173\u6027\u75f4\u5446\uff08alcohol-related dementia\uff0cARD\uff09\u3001\u97e6\u5c3c\u514b\u8111\u75c5\uff08Wernicke\u2032s encephalopathy\uff0cWE\uff09\u3001\u67ef\u8428\u53ef\u592b\u7efc\u5408\u5f81\uff08Korsakoff syndrome\uff0cKS\uff09\u3001\u9152\u7cbe\u6027\u5c0f\u8111\u53d8\u6027\uff08alcoholic cerebellar degeneration\uff0cACD\uff09\u3001Marchiafava-Bignami\u75c5\uff08MBD\uff09\u3001\u8111\u6865\u4e2d\u592e\u9ad3\u9798\u6eb6\u89e3\uff08central pontine myelinolysis\uff0cCPM\uff09\u3001\u9152\u7cbe\u6027\u766b\u75eb\u3001\u9152\u7cbe\u6027\u9707\u98a4-\u8c35\u5984\uff08delirium tremens\uff0cDT\uff09\u548c\u9152\u7cbe\u6027\u7cbe\u795e\u884c\u4e3a\u969c\u788d\u7b49\u3002<\/p>\n

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\u4e09\u3001\u6162\u6027ARBD\u7684\u6d41\u884c\u75c5\u5b66\u7279\u70b9<\/p>\n

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\u56db\u3001\u6162\u6027ARBD\u7684\u4e34\u5e8a\u8868\u73b0\u548c\u7279\u70b9<\/p>\n

\u6839\u636e\u60a3\u8005\u7684\u8d77\u75c5\u6025\u7f13\u3001\u75c5\u7a0b\u957f\u77ed\u7b49\u60c5\u51b5\uff0c\u6162\u6027ARBD\u7684\u4e34\u5e8a\u8868\u73b0\u53ef\u80fd\u51fa\u73b0\u4ee5\u4e0b\u4e0d\u540c\u7efc\u5408\u5f81\u7684\u72ec\u7acb\u8868\u73b0\uff3b1-3\uff0c18-19\uff3d<\/sup>\uff0c\u90e8\u5206\u75c5\u4f8b\u8fd8\u4f1a\u5b58\u5728\u4e24\u4e2a\u6216\u4ee5\u4e0a\u7efc\u5408\u5f81\u7684\u76f8\u4e92\u53e0\u52a0\u3002<\/p>\n

\uff08\u4e00\uff09ARCI<\/p>\n

\u56fd\u5916\u7814\u7a76\u63d0\u793a\uff0c\u9152\u7cbe\u6210\u763e\u8005\u4e2d80%\u5b58\u5728\u4e00\u5b9a\u7a0b\u5ea6\u7684\u8ba4\u77e5\u529f\u80fd\u635f\u5bb3\uff0c\u76ee\u524d\u8ba4\u4e3a\u8fd9\u7c7b\u60a3\u8005\u53ef\u5f52\u7c7b\u4e8eARCI\uff3b1\uff0c18\uff3d<\/sup>\u3002<\/p>\n

ARCI\u4e34\u5e8a\u8868\u73b0\u4e3b\u8981\u4e3a\u8f7b\u5ea6\u6267\u884c\u529f\u80fd\u969c\u788d\u3001\u89c6\u7a7a\u95f4\u529f\u80fd\u969c\u788d\u3001\u8fd0\u52a8\u63a7\u5236\uff08\u5e73\u8861\u3001\u6b65\u6001\uff09\u969c\u788d\uff0c\u65e0\u660e\u663e\u8bb0\u5fc6\u969c\u788d\uff0c\u65e9\u671f\u8868\u73b0\u975e\u5e38\u9690\u533f\uff0c\u96be\u4ee5\u88ab\u60a3\u8005\u53ca\u5bb6\u5c5e\u89c9\u5bdf\uff3b18\uff3d<\/sup>\u3002\u7531\u4e8e\u4e0a\u8ff0\u8868\u73b0\u4e5f\u7f3a\u4e4f\u7279\u5f81\u6027\uff0c\u5f80\u5f80\u9700\u8981\u501f\u52a9\u533b\u5b66\u8bc4\u4f30\u91cf\u8868\u8fdb\u884c\u7efc\u5408\u8bc4\u4ef7\u624d\u80fd\u88ab\u53d1\u73b0\u3002\u7ecf\u8fc7\u6212\u9152\uff0c\u90e8\u5206\u60a3\u8005\u8ba4\u77e5\u529f\u80fd\u53ef\u9006\u8f6c\u6216\u90e8\u5206\u7f13\u89e3\u3002<\/p>\n

ARCI\u4e25\u91cd\u7a0b\u5ea6\u8f83\u8f7b\uff0c\u8868\u73b0\u9690\u533f\u3002\u82e5\u6301\u7eed\u8fdb\u5c55\uff0cARCI\u53ef\u5411ARD\u6216\u5176\u4ed6ARBD\u7c7b\u578b\u53d1\u5c55\u3002<\/p>\n

\uff08\u4e8c\uff09ARD<\/p>\n

ARD\u662f\u7531\u6162\u6027\u9152\u7cbe\u4e2d\u6bd2\u6027\u635f\u5bb3\u4ea7\u751f\u7684\u660e\u663e\u8ba4\u77e5\u529f\u80fd\u969c\u788d\uff0c\u4e3b\u8981\u7531ARCI\u53d1\u5c55\u800c\u6210\uff0c\u53ef\u8f6c\u5316\u4e3aWE\u6216KS\uff0c\u6216\u53e0\u52a0\u97e6\u5c3c\u514b-\u67ef\u8428\u53ef\u592b\u7efc\u5408\u5f81\uff08WKS\uff09\uff3b19\uff3d<\/sup>\u3002\u75c7\u72b6\u8f83ARCI\u4e25\u91cd\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u66f4\u660e\u663e\u7684\u89c6\u7a7a\u95f4\u529f\u80fd\u969c\u788d\u3001\u8bb0\u5fc6\u529b\u4e0b\u964d\u548c\u6267\u884c\u529f\u80fd\u4e0b\u964d\uff1b\u5c24\u5176\u5de5\u4f5c\u8bb0\u5fc6\u3001\u8fd0\u52a8\u901f\u5ea6\u7684\u529f\u80fd\u4e0b\u964d\u66f4\u4e3a\u660e\u663e\uff0c\u65e9\u671f\u8bed\u8a00\u969c\u788d\uff0c\u5982\u5bf9\u6297\u6027\u547d\u540d\uff0c\u7c7b\u522b\u6d41\u7545\u6027\uff0c\u4e00\u822c\u77e5\u8bc6\uff08\u8bed\u4e49\u4efb\u52a1\uff09\u548c\u8a00\u8bed\u8bb0\u5fc6\u5f88\u5c11\u53d7\u5230\u5f71\u54cd\uff0c\u4f46\u665a\u671f\u8a00\u8bed\u529f\u80fd\u4e5f\u4e25\u91cd\u53d7\u635f\uff3b26-27\uff3d<\/sup>\u3002<\/p>\n

\uff08\u4e09\uff09WE<\/p>\n

\u5178\u578b\u7684WE\u60a3\u8005\u53ef\u51fa\u73b03\u7ec4\u7279\u5f81\u6027\u75c7\u72b6\uff1a\u773c\u808c\u9ebb\u75f9\u3001\u7cbe\u795e\u5f02\u5e38\u548c\u5171\u6d4e\u5931\u8c03\uff3b24\uff0c28\uff3d<\/sup>\u3002\u591a\u89c1\u6025\u6027\u6216\u4e9a\u6025\u6027\u53d1\u75c5\uff0c\u5455\u5410\u548c\u773c\u7403\u9707\u98a4\u662f\u6700\u65e9\u51fa\u73b0\u7684\u75c7\u72b6\uff0c\u773c\u808c\u9ebb\u75f9\u662f\u672c\u75c5\u7684\u7279\u5f81\u6027\u8868\u73b0\u4e4b\u4e00\uff0c\u5171\u6d4e\u8fd0\u52a8\u969c\u788d\u5e38\u5728\u773c\u90e8\u75c7\u72b6\u4e4b\u540e\u51fa\u73b0\u3002\u591a\u6570\u60a3\u8005\u521d\u8d77\u65f6\u75c7\u72b6\u76f8\u5f53\u4e25\u91cd\uff0c\u51e0\u5929\u4e4b\u5185\u5373\u53d1\u5c55\u5230\u96be\u4ee5\u7ad9\u7acb\u53ca\u6b65\u884c\uff1b\u8f7b\u578b\u60a3\u8005\u5219\u8868\u73b0\u4e3a\u5c0f\u8111\u6027\u5171\u6d4e\u5931\u8c03\uff0c\u884c\u8d70\u65f6\u6b65\u57fa\u8f83\u5bbd\uff0c\u6613\u4e8e\u503e\u8dcc\u300280%\u4ee5\u4e0a\u60a3\u8005\u5408\u5e76\u7cbe\u795e\u75c7\u72b6\uff0c\u8f7b\u8005\u53ef\u8868\u73b0\u4e3a\u53cd\u5e94\u8fdf\u7f13\u3001\u6ce8\u610f\u529b\u4e0d\u96c6\u4e2d\u3001\u6de1\u6f20\u7b49\uff0c\u4e25\u91cd\u5219\u8868\u73b0\u4e3a\u610f\u8bc6\u6a21\u7cca\u3001\u6613\u6fc0\u60f9\uff0c\u5e76\u4f34\u968f\u5984\u60f3\u3001\u5e7b\u89c9\u6216\u5f02\u5e38\u884c\u4e3a\uff0c\u751a\u81f3\u53d1\u751f\u660f\u8ff7\u3002\u4e2a\u522b\u60a3\u8005\u8fd8\u53ef\u51fa\u73b0\u5934\u75db\u3001\u604d\u60da\u3001\u89c6\u7269\u6a21\u7cca\u3001\u8a00\u8bed\u542b\u7cca\u3001\u6784\u97f3\u4e0d\u8fde\u8d2f\u3001\u542c\u529b\u4e0b\u964d\u7b49\u75c7\u72b6\uff0c\u6216\u51fa\u73b0\u4f4e\u8840\u538b\u3001\u5fc3\u52a8\u8fc7\u901f\u7b49\u8868\u73b0\u3002\u4f46\u4e5f\u6709\u60a3\u8005\u8868\u73b0\u9690\u533f\uff0c\u9700\u8981\u4e34\u5e8a\u533b\u5e08\u4ed4\u7ec6\u68c0\u67e5\u3002<\/p>\n

\uff08\u56db\uff09KS<\/p>\n

\u53c8\u79f0\u9152\u7cbe\u9057\u5fd8\u7efc\u5408\u5f81\u3002\u5178\u578b\u7684\u4e34\u5e8a\u8868\u73b0\u5305\u62ec\u9057\u5fd8\u75c7\u3001\u865a\u6784\u3001\u9519\u6784\u3001\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u3001\u5b9a\u5411\u969c\u788d\u548c\u4eba\u683c\u6539\u53d8\u3002\u60a3\u8005\u7684\u8fd9\u4e9b\u4e34\u5e8a\u8868\u73b0\u5e38\u57fa\u4e8e\u8ba4\u77e5\u529f\u80fd\u5f02\u5e38\u3001\u5b66\u4e60\u80fd\u529b\u4e0b\u964d\u4ee5\u53ca\u4eba\u683c\u6539\u53d8\u3002\u60a3\u8005\u5f80\u5f80\u4e0d\u80fd\u4fdd\u7559\u65b0\u7684\u4fe1\u606f\uff0c\u51fa\u73b0\u9057\u5fd8\u8868\u73b0\uff0c\u4f46\u4e3a\u4e86\u586b\u8865\u8fd9\u65b9\u9762\u7684\u7a7a\u767d\u800c\u5c06\u8fc7\u53bb\u65f6\u95f4\u5185\u66fe\u7ecf\u53d1\u751f\u8fc7\u7684\u4e8b\u4ef6\u8bf4\u6210\u662f\u8fd9\u4e00\u65f6\u95f4\u53d1\u751f\u7684\uff0c\u6216\u4ee5\u4e00\u6bb5\u5185\u5bb9\u8352\u8c2c\u3001\u53d8\u5e7b\u4e0d\u5b9a\u3001\u4e30\u5bcc\u591a\u6837\u7684\u865a\u6784\u7684\u4e8b\u5b9e\u6765\u586b\u8865\u4ed6\u6240\u9057\u5fd8\u7684\u90a3\u4e00\u6bb5\u7ecf\u8fc7\uff0c\u5e76\u5bf9\u5176\u575a\u4fe1\u4e0d\u7591\u3002\u53e6\u5916\uff0c\u60a3\u8005\u5728\u4eba\u683c\u4e0a\u5e38\u8868\u73b0\u4e3a\u8868\u60c5\u51b7\u6f20\uff0c\u7f3a\u4e4f\u4e3b\u52a8\u6027\uff0c\u5bf9\u5468\u56f4\u4eba\u4e8b\u7f3a\u4e4f\u4e3b\u52a8\u610f\u5fd7\u8981\u6c42\u548c\u5173\u5fc3\uff0c\u4f46\u6709\u65f6\u53c8\u663e\u5f97\u81ea\u79c1\u56fa\u6267\u3001\u6b23\u5feb\u80a4\u6d45\uff0c\u6216\u8005\u60c5\u7eea\u6ce2\u52a8\u5341\u5206\u5267\u70c8\uff3b29-30\uff3d<\/sup>\u3002\u7531\u4e8eKS\u5e38\u5e38\u4eceWE\u8fdb\u5c55\u8f6c\u5316\u800c\u5f62\u6210\uff0c\u6545\u4e5f\u5e38\u7528WKS\u6765\u7edf\u79f0\u8fd9\u7ec4\u4e34\u5e8a\u7efc\u5408\u5f81\u3002<\/p>\n

\uff08\u4e94\uff09ACD<\/p>\n

\u8be5\u7efc\u5408\u5f81\u8f83\u4e3a\u5e38\u89c1\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u5171\u6d4e\u5931\u8c03\uff0c\u60a3\u8005\u884c\u8d70\u4e0d\u7a33\u3001\u6613\u8dcc\u5012\uff0c\u4e25\u91cd\u65f6\u80a2\u4f53\u96be\u4ee5\u5b8c\u6210\u534f\u8c03\u6027\u52a8\u4f5c\uff0c\u4f34\u5c0f\u8111\u6027\u9707\u98a4\uff0c\u4e5f\u53ef\u51fa\u73b0\u773c\u9707\u3001\u8a00\u8bed\u542b\u7cca\u6216\u4e0d\u6d41\u5229\u7b49\u3002ACD\u53ef\u4f5c\u4e3aARBD\u9996\u53d1\u8868\u73b0\u6216\u5408\u5e76\u5176\u4ed6\u7efc\u5408\u5f81\u51fa\u73b0\uff0c\u5408\u5e76\u8ba4\u77e5\u969c\u788d\u6700\u4e3a\u591a\u89c1\uff3b21\uff0c31-32\uff3d<\/sup>\u3002<\/p>\n

\uff08\u516d\uff09MBD<\/p>\n

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\uff08\u4e03\uff09CPM<\/p>\n

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\uff08\u516b\uff09DT<\/p>\n

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\uff08\u4e5d\uff09\u9152\u7cbe\u6027\u766b\u75eb<\/p>\n

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\uff08\u4e8c\uff09\u6162\u6027ARBD\u7684\u5f71\u50cf\u5b66\u8868\u73b0<\/p>\n

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2. \u5934\u9885MRI\u68c0\u67e5\uff1a\u76ee\u524d\u6765\u8bf4\uff0cMRI\u662f\u8bca\u65adARBD\u8f83\u4e3a\u7406\u60f3\u7684\u5f71\u50cf\u5b66\u68c0\u67e5\u65b9\u6cd5\u3002MRI\u53ef\u53d1\u73b0\u60a3\u8005\u8111\u5bb9\u91cf\u51cf\u5c11\u3001\u8111\u840e\u7f29\u53ca\u767d\u8d28\u6539\u53d8\uff3b47\uff3d<\/sup>\u3002\u5e7f\u6cdb\u76ae\u8d28\u6027\u8111\u840e\u7f29\u5728MRI\u4e0a\u8868\u73b0\u4e3a\u4e0e\u5e74\u9f84\u4e0d\u7b26\u7684\u5e7f\u6cdb\u7684\u76ae\u8d28\u840e\u7f29\uff0c\u76ae\u8d28\u53d8\u8584\uff0c\u8111\u6c9f\u3001\u8111\u56de\u589e\u5bbd\uff0c\u90e8\u5206\u4f34\u6709\u767d\u8d28\u8131\u9ad3\u9798\uff0c\u6216\u4e0e\u5176\u4ed6\u7c7b\u578b\u8111\u635f\u5bb3\u5e76\u5b58\uff3b49\uff3d<\/sup>\u3002\u5c0f\u8111\u53d8\u6027\u7684\u5f71\u50cf\u5b66\u7279\u5f81\u4e3a\u5c0f\u8111\u840e\u7f29\uff0c\u4ee5\u5c0f\u8111\u8693\u90e8\u840e\u7f29\u4e3a\u4e3b\uff0c\u4e25\u91cd\u65f6\u5c0f\u8111\u76ae\u8d28\u3001\u8693\u90e8\u548c\u6a44\u6984\u4f53\u4e25\u91cd\u840e\u7f29\uff0c\u5e76\u4f34\u6709\u73af\u6c60\u3001\u5c0f\u8111\u4e0a\u6c60\u3001\u6795\u5927\u6c60\u7b49\u8111\u6c60\u6269\u5927\uff3b32\uff3d<\/sup>\u3002\u8111\u767d\u8d28\u8131\u9ad3\u9798MRI\u5373\u53ef\u8868\u73b0\u4e3a\u76ae\u8d28\u4e0b\u767d\u8d28\u53ca\u4fa7\u8111\u5ba4\u5468\u56f4\u591a\u53d1\u7684\u70b9\u72b6\u6216\u6591\u7247\u72b6\u957fTl<\/sub>\u957fT2<\/sub>\u4fe1\u53f7\u5f71\u3002MRI\u5bf9\u8bca\u65adWE\u7075\u654f\u5ea6\u7ea6\u4e3a50%\uff0c\u7279\u5f02\u5ea6\u7ea6\u4e3a90%\uff3b48\uff3d<\/sup>\u3002MRI\u5e73\u626b\u53ef\u53d1\u73b0WE\u60a3\u8005\u7684\u53cc\u4fa7\u4e18\u8111\u548c\u8111\u5e72\u6709\u5bf9\u79f0\u6027\u5f02\u5e38\u4fe1\u53f7\uff0c\u5176\u5178\u578b\u7684\u6539\u53d8\u4e3a\u7b2c\u4e09\u3001\u56db\u8111\u5ba4\u5468\u56f4\u3001\u5bfc\u6c34\u7ba1\u5468\u56f4\u53ca\u4e73\u5934\u4f53\u3001\u56db\u53e0\u4f53\u3001\u4e18\u8111\u6709\u5bf9\u79f0\u6027\u957fT1<\/sub>\u3001\u957fT2<\/sub>\u4fe1\u53f7\uff3b49\uff3d<\/sup>\uff0c\u800c\u4e14\u4e73\u5934\u4f53\u840e\u7f29\uff0c\u88ab\u8ba4\u4e3a\u662fWE\u7684\u7279\u5f81\u6027\u795e\u7ecf\u5f71\u50cf\u5b66\u5f02\u5e38\u3002\u4e73\u5934\u4f53\u5bb9\u79ef\u660e\u663e\u7f29\u5c0f\u662f\u786b\u80fa\u7f3a\u4e4f\u7684\u7279\u6b8a\u6807\u5fd7\u3002CPM\u5728MRI\u4e0a\u8868\u73b0\u4e3a\u6865\u8111\u57fa\u5e95\u90e8\u53cc\u4fa7\u5bf9\u79f0\u6027\u7684\u957fTl<\/sub>\u957fT2<\/sub>\u5f02\u5e38\u4fe1\u53f7\uff0c\u65e0\u5360\u4f4d\u6548\u5e94\uff0c\u4e00\u822c\u4e0d\u4fb5\u72af\u4e2d\u8111\u548c\u5411\u540e\u4fb5\u72af\u4e2d\u592e\u7ea4\u7ef4\u675f\uff0c\u75c5\u7076\u5e38\u7d2f\u53ca\u524d\u989d\u53f6\uff0c\u589e\u5f3a\u626b\u63cf\u65e0\u5f3a\u5316\u3002\u80fc\u80dd\u4f53\u53d8\u6027MRI\u8868\u73b0\u4e3a\u4e3b\u8981\u7d2f\u53ca\u80fc\u80dd\u4f53\u4e2d\u592e\u5c42\uff0c\u591a\u6cbf\u80fc\u80dd\u4f53\u957f\u8f74\u6574\u4f53\u5206\u5e03\uff0c\u6a2a\u65ad\u4f4d\u663e\u793a\u75c5\u53d8\u53cc\u4fa7\u5bf9\u79f0\uff0c\u4e8eT1<\/sub>WI\u4e0a\u4e3a\u7b49\u6216\u7a0d\u4f4e\u4fe1\u53f7\uff0cT2<\/sub>WI\u4e0a\u4e3a\u9ad8\u4fe1\u53f7\uff0c\u8fb9\u754c\u8f83\u6a21\u7cca\uff0c\u77e2\u72b6\u4f4dT2<\/sub>WI\u53ef\u4ee5\u663e\u793a\u80fc\u80dd\u4f53\u4e0a\u3001\u4e0b\u7f18\u672a\u53d7\u7d2f\uff0c\u4ece\u800c\u5f62\u6210\u5206\u5c42\u72b6\u6539\u53d8\u5373\u201c\u5939\u5fc3\u997c\u5e72\u5f81\u201d\u3002\u6025\u6027\u671f\u80fc\u80dd\u4f53\u4ee5\u660e\u663e\u80bf\u80c0\u4e3a\u4e3b\uff0c\u4e9a\u6025\u6027\u671f\u80fc\u80dd\u4f53\u53ef\u6b63\u5e38\u6216\u8f7b\u5ea6\u80bf\u80c0\u3001\u840e\u7f29\uff0c\u6162\u6027\u671f\u80fc\u80dd\u4f53\u840e\u7f29\uff3b33\uff0c50\uff3d<\/sup>\u3002\u80fc\u80dd\u4f53\u56ca\u53d8\u3001\u7a7a\u6d1e\u3001\u5206\u5c42\u574f\u6b7b\u662f\u6162\u6027\u9152\u7cbe\u4e2d\u6bd2\u6027\u8111\u767d\u8d28\u635f\u4f24\u7684\u7279\u5f81\u6027\u8868\u73b0\u3002\u78c1\u5171\u632f\u6db2\u4f53\u8870\u51cf\u53cd\u8f6c\u6062\u590d\uff08FLAIR\uff09\u5e8f\u5217\u80fd\u591f\u6e05\u695a\u663e\u793a\u4fa7\u8111\u5ba4\u65c1\u7684\u5f02\u5e38\u4fe1\u53f7\u3002<\/p>\n

\u7531\u4e8e\u9152\u7cbe\u5bf9\u8840\u8111\u5c4f\u969c\u7684\u635f\u5bb3\u8f83\u4e3a\u7f13\u6162\u548c\u9690\u533f\uff0c\u78c1\u5171\u632f\u589e\u5f3a\u663e\u50cf\u5bf9\u6162\u6027ARBD\u7684\u8bca\u65ad\u5e2e\u52a9\u4e0d\u5927\uff0c\u4f46\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u6709\u5229\u4e8e\u5176\u4ed6\u75be\u75c5\u7684\u9274\u522b\u8bca\u65ad\u3002<\/p>\n

\u78c1\u5171\u632f\u5f25\u6563\u52a0\u6743\u6210\u50cf\uff08DWI\uff09\u5e8f\u5217\u5bf9ARBD\u7684\u65e9\u671f\u767d\u8d28\u75c5\u7076\u53ef\u80fd\u66f4\u52a0\u654f\u611f\uff08DWI\u4fe1\u53f7\u5347\u9ad8\u8868\u73b0\uff09\u3002ARBD\u60a3\u8005\u7684\u8111\u90e8\u78c1\u5171\u632f\u6ce2\u8c31\u6210\u50cf\uff08MRS\uff09\u5e38\u663e\u793a\u4e18\u8111\u548c\u5c0f\u8111N-\u4e59\u9170\u5929\u51ac\u6c28\u9178\/\u808c\u9178\u6bd4\u503c\uff08NAA\/Cr\uff09\u4e0b\u964d\uff0c\u800c\u786b\u80fa\u6cbb\u7597\u6709\u6548\u540e\u6bd4\u503c\u5347\u9ad8\uff0c\u4e14\u4e0e\u4e34\u5e8a\u75c7\u72b6\u6539\u5584\u60c5\u51b5\u4e00\u81f4\uff0c\u56e0\u6b64\uff0cMRS\u53ef\u7528\u4e8e\u6cbb\u7597\u524d\u540e\u7684\u7597\u6548\u5bf9\u6bd4\uff3b11\uff0c16-17\uff3d<\/sup>\u3002<\/p>\n

\u968f\u7740\u529f\u80fdMRI\uff08fMRI\uff09\u7684\u5e94\u7528\uff0cfMRI\u89e3\u91ca\u4e86\u9152\u7cbe\u957f\u671f\u6444\u5165\u540e\u7684\u795e\u7ecf\u73af\u8def\u6539\u53d8\uff0c\u957f\u671f\u9152\u7cbe\u6444\u5165\u9996\u5148\u53ef\u7d2f\u53ca\u7eb9\u72b6\u4f53\u4ea7\u751f\u9152\u7cbe\u4f9d\u8d56\u548c\u6210\u763e\u5e76\u9010\u6e10\u6539\u53d8\u989d\u53f6\/\u524d\u989d\u53f6\u73af\u8def\uff0c\u5bfc\u81f4\u6267\u884c\u63a7\u5236\u529f\u80fd\u53d7\u635f\uff3b51-54\uff3d<\/sup>\u3002\u8fd1\u5e74\u6765\u5927\u6837\u672c\u7684\u5f71\u50cf\u7814\u7a76\u53d1\u73b0\u957f\u671f\u9152\u7cbe\u6444\u5165\u53ef\u5bfc\u81f4\u8111\u7070\u8d28\u548c\u767d\u8d28\u7684\u8fdb\u884c\u6027\u840e\u7f29\uff0c\u63d0\u793a\u957f\u671f\u9152\u7cbe\u6444\u5165\u901a\u8fc7\u51cf\u5c11\u8111\u5bb9\u91cf\u5bfc\u81f4\u8ba4\u77e5\u529f\u80fd\u4e0b\u964d\uff3b55-56\uff3d<\/sup>\u3002\u6b64\u5916\uff0c\u4e2d\u56fd\u5b66\u8005\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86\u9152\u7cbe\u6027\u8ba4\u77e5\u969c\u788d\u60a3\u8005\u5176\u4ed6\u8111\u533a\u7684\u529f\u80fd\u5f71\u50cf\u5b66\u53d8\u5316\uff0c\u53d1\u73b0\u53f3\u8111\u5c9b\u548c\u6954\u524d\u53f6\u7684\u52a8\u6001\u5168\u8111\u4fe1\u53f7\u62d3\u6251\uff08global signal topography\uff0cGST\uff09\u6539\u53d8\u662f\u63d0\u793a\u9152\u7cbe\u4f7f\u7528\u969c\u788d\u60a3\u8005\u51fa\u73b0\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u7684\u5f71\u50cf\u7279\u5f81\uff3b57\uff3d<\/sup>\uff1b\u5728\u8111\u529f\u80fd\u8fde\u63a5\u5bc6\u5ea6\uff08functional connectivity density\uff0cFCD\uff09\u7684\u5f71\u50cf\u5206\u6790\u4e2d\uff0c\u53d1\u73b0\u4e86\u5de6\u5185\u4fa7\u989d\u56de\u3001\u5de6\u6d77\u9a6c\u65c1\u56de\u3001\u5de6\u6795\u4e0b\u53f6\u548c\u5de6\u5c0f\u8111\u7684FCD\u663e\u8457\u6539\u53d8\u4e0e\u8ba4\u77e5\u4e0b\u964d\u5bc6\u5207\u76f8\u5173\uff3b58\uff3d<\/sup>\uff0c\u6709\u5229\u4e8e\u5728\u76ae\u8d28\u51fa\u73b0\u7ed3\u6784\u6027\u840e\u7f29\u548c\u91cf\u8868\u51fa\u73b0\u8bc4\u5206\u5f02\u5e38\u524d\u68c0\u6d4b\u5230\u9152\u7cbe\u4ecb\u5bfc\u7684\u8ba4\u77e5\u529f\u80fd\u4e0b\u964d\u3002<\/p>\n

\u6b64\u5916\uff0c\u6211\u56fd\u5b66\u8005\u4e5f\u53d1\u73b0PET-CT\u53ef\u53cd\u6620\u51fa\u9152\u7cbe\u6027\u8ba4\u77e5\u969c\u788d\u60a3\u8005\u5b58\u5728\u5927\u8111\u989d\u9876\u53f6\u3001\u6795\u53f6\u7b49\u90e8\u4f4d\u8461\u8404\u7cd6\u4ee3\u8c22\u6c34\u5e73\u51cf\u4f4e\uff3b59\uff3d<\/sup>\uff0c\u63d0\u793aPET-CT\u5728\u660e\u786e\u60a3\u8005\u8ba4\u77e5\u529f\u80fd\u7684\u795e\u7ecf\u673a\u5236\u4e2d\u5177\u6709\u4e00\u5b9a\u6307\u5bfc\u610f\u4e49\u3002<\/p>\n

\u63a8\u8350\u610f\u89c11\uff1aMRI\u53ef\u68c0\u6d4b\u5230\u6162\u6027ARBD\u7279\u5b9a\u4e34\u5e8a\u7efc\u5408\u5f81\u7684\u7279\u5f81\u6027\u5f71\u50cf\u5b66\u6539\u53d8\uff0c\u5e76\u4e00\u5b9a\u7a0b\u5ea6\u53cd\u6620\u4e86\u7684\u75c5\u7406\u53d8\u5316\u7279\u5f81\u548c\u4e25\u91cd\u7a0b\u5ea6\uff0c\u53ef\u8f85\u52a9\u8bca\u65ad\u6162\u6027ARBD\u548c\u9274\u522b\u5176\u4ed6\u8111\u75be\u75c5\u3002\uff081B\uff09<\/p>\n

\u63a8\u8350\u610f\u89c12\uff1afMRI\u6216PET-CT\u68c0\u67e5\u53ef\u4e00\u5b9a\u7a0b\u5ea6\u53cd\u6620\u6162\u6027ARBD\u7684\u75c5\u7406\u751f\u7406\u53d8\u5316\u7279\u5f81\uff0c\u53ef\u8f85\u52a9\u5206\u6790\u6162\u6027ARBD\u7684\u529f\u80fd\u6539\u53d8\u548c\u4e25\u91cd\u7a0b\u5ea6\u3002\uff081C\uff09<\/p>\n

\u516d\u3001\u6162\u6027ARBD\u7684\u7b5b\u67e5\u3001\u8bc4\u4f30\u548c\u4e34\u5e8a\u8bca\u65ad<\/p>\n

\uff08\u4e00\uff09\u6162\u6027ARBD\u7684\u7b5b\u67e5\u548c\u8bc4\u4f30\u91cf\u8868<\/p>\n

1. \u9152\u7cbe\u6444\u5165\u91cf\u7684\u8bb0\u5f55\uff1a\u7f8e\u56fd\u56fd\u5bb6\u9152\u7cbe\u6ee5\u7528\u4e0e\u9152\u7cbe\u4e2d\u6bd2\u7814\u7a76\u534f\u4f1a\uff08National Institute on Alcohol Abuse and Alcoholism\uff0cNIAAA\uff09\u5236\u5b9a\u4e86\u4e00\u5957\u9152\u7cbe\u6444\u5165\u91cf\u8ba1\u91cf\u7cfb\u7edf\uff0c\u76ee\u524d\u88ab\u5e7f\u6cdb\u4f7f\u7528\u3002NIAAA\u5b9a\u4e49\u4e00\u4e2a\u6807\u51c6\u9152\u7cbe\u5355\u4f4d\uff08\u6807\u51c6\u676f\uff09\u76f8\u5f53\u4e8e14 g\u7eaf\u9152\u7cbe\uff3b60\uff3d<\/sup>\u3002\u65e2\u5f80\u8ba4\u4e3a\u996e\u9152\u5bfc\u81f4\u9152\u7cbe\u4e2d\u6bd2\u98ce\u9669\u7684\u4e0b\u9650\u662f\u7537\u6027\u6bcf\u5468\u4e0d\u8d85\u8fc714\u4e2a\u9152\u7cbe\u5355\u4f4d\uff0c\u5973\u6027\u6bcf\u5468\u4e0d\u8d85\u8fc77\u4e2a\u9152\u7cbe\u5355\u4f4d\uff3b61\uff3d<\/sup>\u3002\u4f46\u9700\u8981\u6ce8\u610f\uff0c\u4e0d\u540c\u56fd\u5bb6\u6216\u5730\u533a\u5bf9\u6807\u51c6\u9152\u7cbe\u5355\u4f4d\u7684\u5b9a\u4e49\u6709\u6240\u4e0d\u540c\uff0c\u9664\u4e0a\u8ff0\u63d0\u53ca\u7684\u66f4\u4e3a\u5e7f\u6cdb\u4f7f\u7528\u7684\u7f8e\u56fd\u6807\u51c6\u5916\uff0c\u82f1\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u7684\u6807\u51c6\u9152\u7cbe\u5355\u4f4d\u5219\u5206\u522b\u76f8\u5f53\u4e8e8 g\u300110 g\u7684\u7eaf\u9152\u7cbe\uff3b19\uff3d<\/sup>\uff0c\u5bf9\u4e8e\u4e34\u5e8a\u7814\u7a76\u7684\u8d44\u6599\u91c7\u96c6\u65f6\u9700\u8981\u660e\u786e\u548c\u6ce8\u610f\u3002\u672c\u6307\u5357\u5efa\u8bae\u4f7f\u7528\u6362\u7b97\u540e\u7684\u7eaf\u9152\u7cbe\u91cf\uff08\u514b\uff09\u4f5c\u4e3a\u9152\u7cbe\u6444\u5165\u91cf\u7684\u91c7\u96c6\u3001\u8bb0\u5f55\u6807\u51c6\u3002\u8d8a\u6765\u8d8a\u591a\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u5229\u7528\u5242\u91cf\u5206\u5c42\u8fdb\u884c\u968f\u8bbf\u7814\u7a76\uff0c\u7ed3\u679c\u53d1\u73b0\u6bcf\u5468\u8d85\u8fc714\u4e2a\u9152\u7cbe\u5355\u4f4d\u7684\u9152\u7cbe\u6444\u5165\u4e0e\u8ba4\u77e5\u969c\u788d\u7684\u53d1\u751f\u98ce\u9669\u5bc6\u5207\u76f8\u5173\uff0c\u4e14\u968f\u7740\u79ef\u7d2f\u7684\u589e\u52a0\uff0c\u75f4\u5446\u98ce\u9669\u8fdb\u884c\u6027\u589e\u9ad8\uff3b62\uff3d<\/sup>\u3002<\/p>\n

2. \u9152\u7cbe\u4f9d\u8d56\u7a0b\u5ea6\u7684\u7b5b\u67e5\uff1a\uff081\uff09CAGE\u91cf\u8868\u4e0e\u9152\u7cbe\u4f7f\u7528\u969c\u788d\u7b5b\u67e5\uff08alcohol use disorders identification test\uff0cAUDIT\uff09\u91cf\u8868\uff1a\u8fd92\u4e2a\u91cf\u8868\u4e3b\u8981\u7528\u4e8e\u521d\u6b65\u7b5b\u67e5\u60a3\u8005\u662f\u5426\u5b58\u5728\u9152\u7cbe\u4f9d\u8d56\u6216\u9152\u7cbe\u4f7f\u7528\u969c\u788d\u3002CAGE\u91cf\u8868\u5305\u62ec\u4e864\u4e2a\u7b80\u5355\u6613\u61c2\u7684\u95ee\u9898\uff0c\u5728\u4e34\u5e8a\u4e0a\u8f83\u4e3a\u5e38\u7528\u4e8eARBD\u60a3\u8005\u996e\u9152\u7a0b\u5ea6\u7684\u521d\u7b5b\uff3b42\uff3d<\/sup>\u3002CAGE\u91cf\u8868\u7684\u7f3a\u9677\u5728\u4e8e\u6ca1\u6709\u6db5\u76d6\u4e00\u6b21\u6027\u5927\u91cf\u996e\u9152\u5bfc\u81f4\u6025\u6027\u9152\u7cbe\u4e2d\u6bd2\u6027\u8111\u635f\u4f24\u7684\u60c5\u51b5\uff0c\u800cAUDIT\u91cf\u8868\u5219\u5f25\u8865\u4e86CAGE\u91cf\u8868\u5728\u8fd9\u65b9\u9762\u7684\u4e0d\u8db3\uff3b42\uff0c63\uff3d<\/sup>\u3002AUDIT\u91cf\u8868\u5305\u62ec\u4e8610\u4e2a\u95ee\u9898\uff0c\u5927\u6982\u9700\u8981\u4e34\u5e8a\u533b\u5e08\u82b1\u8d392~3 min\u5b8c\u6210\uff0c\u5e76\u6700\u540e\u7ed9\u51fa0~40\u5206\u7684\u8bc4\u5206\uff0cAUDIT\u91cf\u8868\u22658\u5206\u63d0\u793a\u60a3\u8005\u5b58\u5728\u98ce\u9669\/\u6709\u5bb3\u6027\u996e\u9152\u6216\u4e2d\u91cd\u5ea6\u9152\u7cbe\u4f9d\u8d56\u3002AUDIT\u91cf\u8868\u5728\u6211\u56fd\u5df2\u6709\u5927\u91cf\u4e34\u5e8a\u7814\u7a76\u4f7f\u7528\u7ecf\u9a8c\uff0c\u5176\u4fe1\u5ea6\u3001\u6548\u5ea6\u5f97\u5230\u5e7f\u6cdb\u8ba4\u53ef\uff3b64\uff3d<\/sup>\u3002\u867d\u7136AUDIT\u91cf\u8868\u7684\u51c6\u786e\u6027\u6709\u6240\u63d0\u9ad8\uff0c\u4f46\u662f\u5176\u4e34\u5e8a\u6548\u7387\u504f\u4f4e\uff0c\u56e0\u6b64AUDIT\u91cf\u8868\u7684\u4e34\u5e8a\u7b80\u5316\u7248\uff08AUDIT-C\u91cf\u8868\uff09\u4e5f\u5f97\u5230\u8d8a\u6765\u8d8a\u591a\u7814\u7a76\u8005\u7684\u8ba4\u53ef\u548c\u4f7f\u7528\uff3b65-67\uff3d<\/sup>\uff0c\u5176\u4e2d\u7684\u6761\u76ee\u80fd\u5feb\u901f\u660e\u786e\u60a3\u8005\u7684\u9152\u7cbe\u6444\u5165\u91cf\u548c\u9891\u7387\u3002\uff082\uff09\u56fd\u5916\u8fd8\u6709\u5176\u4ed6\u5bf9\u9152\u7cbe\u4f9d\u8d56\u8fdb\u884c\u5feb\u901f\u8bc4\u4f30\u7684\u5efa\u8bae\u91cf\u8868\uff0c\u6bd4\u5982\u9152\u7cbe\u5feb\u901f\u7b5b\u67e5\u8bd5\u9a8c\uff08the fast alcohol screening test\uff0cFAST\uff09\uff3b68\uff3d<\/sup>\u3001AUDIT-PC\u91cf\u8868\uff3b69\uff3d<\/sup>\uff0c\u6216\u8005\u4f7f\u7528\u57fa\u4e8eAUDIT\u91cf\u8868\u548cCAGE\u91cf\u8868\u884d\u751f\u7684Five-SHOT\u91cf\u8868\uff3b70\uff3d<\/sup>\uff0c\u4f46\u8fd9\u4e9b\u91cf\u8868\u5728\u6211\u56fd\u5c1a\u6ca1\u6709\u7814\u7a76\u660e\u786e\u5176\u4fe1\u5ea6\u548c\u6548\u5ea6\u3002<\/p>\n

3. \u9152\u7cbe\u6e34\u6c42\u7a0b\u5ea6\u7684\u8bc4\u4f30\uff1a\u60a3\u8005\u5bf9\u9152\u7cbe\u7684\u6e34\u6c42\u662f\u9152\u7cbe\u6210\u763e\u540e\u7684\u4e00\u79cd\u5f3a\u8feb\u6027\u884c\u4e3a\uff0c\u662f\u5bfc\u81f4\u60a3\u8005\u96be\u4ee5\u6212\u9664\u996e\u9152\u7684\u91cd\u8981\u56e0\u7d20\u4e4b\u4e00\uff0c\u662f\u9884\u6d4b\u60a3\u8005\u80fd\u5426\u6212\u9152\u548c\u9884\u6d4b\u590d\u996e\u98ce\u9669\u7684\u53cd\u5e94\u6307\u6807\uff0c\u76f4\u63a5\u5f71\u54cd\u4e86ARBD\u60a3\u8005\u7684\u9884\u540e\u3002\u56fd\u5916\u5e38\u7528\u5f3a\u5236\u6027\u996e\u9152\u95ee\u5377\uff08obsessive compulsive drinking scale\uff0cOCDS\uff09\u5bf9\u9152\u7cbe\u6e34\u6c42\u8fdb\u884c\u4e34\u5e8a\u8bc4\u4f30\u548c\u4e34\u5e8a\u7814\u7a76\u7684\u968f\u8bbf\uff0c\u76ee\u524d\u672c\u6587\u901a\u8baf\u4f5c\u8005\u56e2\u961f\u5df2\u5728\u6211\u56fd\u4eba\u7fa4\u4e2d\u6709\u4fe1\u5ea6\u548c\u6548\u5ea6\u7684\u7814\u7a76\u6570\u636e\u8bc1\u5b9e\u5176\u5e94\u7528\u4ef7\u503c\uff3b71\uff3d<\/sup>\uff08\u9644\u5f551\uff0c\u626b\u63cf\u4e8c\u7ef4\u7801\u67e5\u770b\u9644\u5f55\uff09\u3002<\/p>\n

\u9644\u5f551 \u5f3a\u5236\u6027\u996e\u9152\u95ee\u5377\uff08\u6c49\u5316\u7248\uff09<\/p>\n

4. ARBD\u8ba4\u77e5\u969c\u788d\u7684\u8bc4\u4f30\uff1a\u8bb0\u5fc6\u529b\u548c\u5176\u4ed6\u8ba4\u77e5\u529f\u80fd\u53d7\u635f\u662fARBD\u60a3\u8005\u5e38\u89c1\u7684\u4e34\u5e8a\u8868\u73b0\uff0c\u5176\u635f\u5bb3\u7a0b\u5ea6\u7684\u91cf\u5316\u548c\u8ba4\u77e5\u969c\u788d\u7684\u786e\u5b9a\u9700\u8981\u4f7f\u7528\u8ba4\u77e5\u529f\u80fd\u8bc4\u5b9a\u91cf\u8868\u534f\u52a9\u8bca\u65ad\u3002\u4e34\u5e8a\u5e38\u7528\u7684\u8ba4\u77e5\u529f\u80fd\u8bc4\u5b9a\u91cf\u8868\u5305\u62ec\u7b80\u6613\u667a\u80fd\u7cbe\u795e\u72b6\u6001\u68c0\u67e5\u91cf\u8868\uff08mini-mental state examination\uff0cMMSE\uff09\u548c\u8499\u7279\u5229\u5c14\u8ba4\u77e5\u8bc4\u4f30\u91cf\u8868\uff08montreal cognitive assessment\uff0cMoCA\uff09\u3002\u7531\u4e8eMoCA\u91cf\u8868\u6d89\u53ca\u66f4\u591a\u7684\u8ba4\u77e5\u529f\u80fd\u57df\uff0c\u5c24\u5176\u662f\u89c6\u7a7a\u95f4\u548c\u6267\u884c\u80fd\u529b\u65b9\u9762\u7684\u68c0\u6d4b\uff0c\u5bf9\u4e8eARBD\u60a3\u8005\u66f4\u4e3a\u63a8\u8350\uff0c\u5e76\u6709\u52a9\u4e8e\u65e9\u671f\u7b5b\u67e5KS\uff3b72-73\uff3d<\/sup>\u3002\u6709\u7814\u7a76\u8868\u660e\uff0c\u4ee5\u672a\u77eb\u6b63\u7684MoCA<26\u5206\u4f5c\u4e3a\u6162\u6027\u996e\u9152\u8005\u5408\u5e76\u8ba4\u77e5\u969c\u788d\u7684\u5206\u754c\u503c\u5177\u6709\u8f83\u9ad8\u7684\u8bca\u65ad\u7075\u654f\u5ea6\u548c\u7279\u5f02\u5ea6\uff3b73-76\uff3d<\/sup>\u3002<\/p>\n

\u9664MoCA\u5916\uff0c\u6709\u7814\u7a76\u8005\u5f00\u53d1\u4e86\u4e13\u7528\u4e8eARBD\u8ba4\u77e5\u8bc4\u4f30\u7684\u91cf\u8868\u6216\u8bc4\u4ef7\u7cfb\u7edf\uff0c\u5305\u62ec\u9152\u7cbe\u76f8\u5173\u795e\u7ecf\u5fc3\u7406\u635f\u5bb3\u7b80\u6613\u8bc4\u4f30\uff08Brief Evaluation of Alcohol-Related Neuropsychological Impairments\uff0cBEARNI\uff09\u7cfb\u7edf\u3001\u6267\u884c\u529f\u80fd\u7b80\u6613\u8bc4\u4ef7\u5de5\u5177\uff08brief executive-function assessment tool\uff0cBEAT\uff09\u7b49\uff0c\u4f46\u5176\u5e94\u7528\u4ef7\u503c\u5c1a\u9700\u7814\u7a76\u8fdb\u4e00\u6b65\u660e\u786e\uff3b77-80\uff3d<\/sup>\u3002<\/p>\n

\u63a8\u8350\u610f\u89c13\uff1aAUDIT\u91cf\u8868\u7528\u4e8e\u8bc4\u4f30\u6162\u6027ARBD\u60a3\u8005\u7684\u9152\u7cbe\u4f7f\u7528\u969c\u788d\u53ca\u5176\u4e25\u91cd\u7a0b\u5ea6\u5177\u6709\u826f\u597d\u7684\u4fe1\u5ea6\u548c\u6548\u5ea6\u3002\uff081B\uff09<\/p>\n

\u63a8\u8350\u610f\u89c14\uff1aOCDS\u7528\u4e8e\u8bc4\u4f30\u6162\u6027ARBD\u60a3\u8005\u9152\u7cbe\u6e34\u6c42\u7684\u7a0b\u5ea6\uff0c\u53ef\u7528\u4e8e\u4e34\u5e8a\u8bc4\u4f30\u548c\u4e34\u5e8a\u7814\u7a76\u7684\u968f\u8bbf\uff0c\u5177\u6709\u826f\u597d\u7684\u4fe1\u5ea6\u548c\u6548\u5ea6\u3002\uff081B\uff09<\/p>\n

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\uff08\u4e8c\uff09\u75c5\u56e0\u6cbb\u7597<\/p>\n

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\uff08\u4e09\uff09\u7ea0\u6b63\u8425\u517b\u5931\u8c03<\/p>\n

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\u63a8\u8350\u610f\u89c118\uff1a\u7ea0\u6b63ARBD\u7684\u8425\u517b\u5931\u8c03\u662f\u7f13\u89e3\u75c5\u60c5\u3001\u65e9\u65e5\u6062\u590d\u7684\u57fa\u7840\uff0c\u5305\u62ec\u7ed9\u4e88\u591a\u79cd\u7ef4\u751f\u7d20\u3001\u5fc5\u8981\u8102\u80aa\u9178\u3001\u690d\u7269\u86cb\u767d\u548c\u690d\u7269\u591a\u7cd6\u7b49\u3002\uff081D\uff09<\/p>\n

\uff08\u56db\uff09\u8111\u4fdd\u62a4\u6cbb\u7597<\/p>\n

\u957f\u671f\u9157\u9152\u7684\u60a3\u8005\u8111\u5185\u5b58\u5728\u8fc7\u6c27\u5316\u7269\u548c\u81ea\u7531\u57fa\u635f\u4f24\u53ca\u660e\u663e\u7684\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u6c34\u5e73\u4f4e\u4e0b\uff3b109-110\uff0c112\uff3d<\/sup>\uff0c\u56e0\u6b64\uff0c\u9002\u5f53\u800c\u6709\u6548\u7684\u795e\u7ecf\u4fdd\u62a4\u6cbb\u7597\u6709\u52a9\u4e8e\u6539\u5584\u6162\u6027ARBD\u7684\u5404\u79cd\u75c7\u72b6\u3002\u9664\u4f7f\u7528\u7ef4\u751f\u7d20C\u548c\u8865\u5145B\u65cf\u7ef4\u751f\u7d20\u5982\u7532\u94b4\u80fa\u5916\uff0c\u8fd8\u53ef\u7ed9\u4e88\u81ea\u7531\u57fa\u6e05\u9664\u5242\u5982\u4f9d\u8fbe\u62c9\u5949\uff0c\u7ebf\u7c92\u4f53\u4fdd\u62a4\u5242\u5982\u827e\u5730\u82ef\u918c\u3001\u8f85\u9176Q10\u7b49\uff0c\u4ee5\u53ca\u795e\u7ecf\u8425\u517b\u836f\u7269\u5982\u9f20\u795e\u7ecf\u751f\u957f\u56e0\u5b50\u3001\u5965\u62c9\u897f\u5766\u7b49\u3002\u672c\u6307\u5357\u56e2\u961f\u7ec4\u7ec7\u56fd\u5185\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u53d1\u73b0\uff0c\u4f7f\u7528\u4f9d\u8fbe\u62c9\u5949\u6297\u6c27\u5316\u6cbb\u7597\u3001\u9f20\u795e\u7ecf\u751f\u957f\u56e0\u5b50\u7684\u8425\u517b\u795e\u7ecf\u6cbb\u7597\u53ef\u4ee5\u51cf\u5c11\u6162\u6027ARBD\u60a3\u8005\u5bf9\u9152\u7cbe\u7684\u6e34\u6c42\uff0c\u6539\u5584\u6291\u90c1\u60c5\u7eea\u548c\u7761\u7720\u969c\u788d\uff1b\u5176\u4e2d\uff0c\u4f9d\u8fbe\u62c9\u5949\u8fd8\u53ef\u6539\u5584\u6162\u6027ARBD\u60a3\u8005\u7684\u6267\u884c\u529f\u80fd\uff0c\u5305\u62ec\u5de5\u4f5c\u8bb0\u5fc6\u548c\u7a7a\u95f4\u8bb0\u5fc6\uff3b111\uff3d<\/sup>\u3002\u5176\u4ed6\u795e\u7ecf\u8425\u517b\u3001\u795e\u7ecf\u4fdd\u62a4\u6cbb\u7597\u7684\u5faa\u8bc1\u4f9d\u636e\u5c1a\u9700\u8981\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/p>\n

\u63a8\u8350\u610f\u89c119\uff1a\u4f9d\u8fbe\u62c9\u5949\u7684\u6297\u6c27\u5316\u6cbb\u7597\u53ef\u51cf\u5c11\u6162\u6027ARBD\u60a3\u8005\u7684\u9152\u7cbe\u6e34\u6c42\uff0c\u5e76\u6539\u5584\u8ba4\u77e5\u6267\u884c\u529f\u80fd\u3001\u6291\u90c1\u60c5\u7eea\u548c\u7761\u7720\u969c\u788d\uff1b\u9f20\u795e\u7ecf\u751f\u957f\u56e0\u5b50\u7684\u795e\u7ecf\u8425\u517b\u6cbb\u7597\u53ef\u51cf\u5c11\u6162\u6027ARBD\u60a3\u8005\u7684\u9152\u7cbe\u6e34\u6c42\u3001\u6291\u90c1\u60c5\u7eea\u548c\u7761\u7720\u969c\u788d\u3002\uff081A\uff09<\/p>\n

\u63a8\u8350\u610f\u89c120\uff1a\u5176\u4ed6\u6297\u6c27\u5316\u3001\u795e\u7ecf\u8425\u517b\u6cbb\u7597\u6162\u6027ARBD\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u4ecd\u9700\u8981\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002\uff082D\uff09<\/p>\n

\uff08\u4e94\uff09\u5404\u578b\u7efc\u5408\u5f81\u7684\u6cbb\u7597<\/p>\n

l. WE\u548cKS\uff1aWE\u548cKS\u7684\u53d1\u75c5\u673a\u5236\u4e3b\u8981\u662f\u786b\u80fa\u7f3a\u4e4f\uff0c\u56e0\u6b64\u53ef\u79ef\u6781\u901a\u8fc7\u975e\u80a0\u9053\u8865\u5145B\u65cf\u7ef4\u751f\u7d20\uff0c\u5305\u62ec\u7ef4\u751f\u7d20B1\u6ce8\u5c04\u6db2\u808c\u8089\u6ce8\u5c04\u53ca\u7532\u94b4\u80fa\u6ce8\u5c04\u6db2\u808c\u8089\u6216\u9759\u8109\u6ce8\u5c04\uff081 000 \u03bcg\uff0c1\u6b21\/d\uff09\u3002<\/p>\n

2. ARD\uff1a\u5927\u8111\u80c6\u78b1\u80fd\u795e\u7ecf\u5143\u529f\u80fd\u53d7\u635f\u662fARD\u7684\u4e3b\u8981\u673a\u5236\uff0c\u9152\u7cbe\u6291\u5236\u4e59\u9170\u80c6\u78b1\u6d3b\u6027\uff0c\u5bfc\u81f4\u6d77\u9a6c\u548c\u989d\u53f6\u80c6\u78b1\u80fd\u795e\u7ecf\u5143\u4e22\u5931\u7b49\u5f15\u8d77\u8ba4\u77e5\u529f\u80fd\u4e0b\u964d\uff3b113-114\uff3d<\/sup>\u3002\u4e34\u5e8a\u53ef\u4f7f\u7528\u80c6\u78b1\u916f\u9176\u6291\u5236\u5242\u591a\u5948\u54cc\u9f50\u548cNMDA\u53d7\u4f53\u975e\u7ade\u4e89\u6027\u62ee\u6297\u5242\u7f8e\u91d1\u521a\uff0c\u63a8\u8350\u5242\u91cf\u4e3a\uff1a\u591a\u5948\u54cc\u9f505~10 mg\u53e3\u670d\uff0c1\u6b21\/d\uff0c4~6\u5468\u540e\u52a0\u91cf\u81f310 mg\u53e3\u670d\uff0c1\u6b21\/d\uff1b\u7f8e\u91d1\u521a\u6cbb\u7597\u524d3\u5468\u6309\u6bcf\u5468\u9012\u589e5 mg\/d\u5242\u91cf\u81f310 mg\u53e3\u670d\uff0c2\u6b21\/d\uff3b115-116\uff3d<\/sup>\u3002<\/p>\n

3. DT\uff1a\u9996\u9009\u82ef\u4e8c\u6c2e\u7c7b\u836f\u7269\u77ed\u671f\u5e94\u7528\uff0c\u4f46\u4e0d\u540c\u82ef\u4e8c\u6c2e\u7c7b\u836f\u7269\u5728\u4e0d\u540c\u60a3\u8005\u4e4b\u95f4\u7684\u836f\u7269\u53cd\u5e94\u4e0d\u5c3d\u76f8\u540c\uff3b39\uff3d<\/sup>\uff1b\u5fc5\u8981\u65f6\u8054\u7528\u5b89\u5168\u6027\u9ad8\u7684\u6297\u7cbe\u795e\u75c5\u836f\uff3b117\uff3d<\/sup>\uff1b\u5bf9\u4e8e\u75c5\u60c5\u4e25\u91cd\u6216\u5bf9\u82ef\u4e8c\u6c2e\u7c7b\u836f\u7269\u7597\u6548\u53cd\u5e94\u5dee\u7684\u60a3\u8005\uff0c\u53ef\u8003\u8651\u6362\u7528\u5361\u9a6c\u897f\u5e73\u3001\u5965\u5361\u897f\u5e73\u6216\u82ef\u5df4\u6bd4\u59a5\u7b49\u6cbb\u7597\uff0c\u5fc5\u8981\u65f6\u5728\u91cd\u75c7\u76d1\u62a4\u5ba4\u5185\u4e25\u5bc6\u89c2\u5bdf\u4e0b\u4f7f\u7528\u4e19\u6cca\u915a\u6cbb\u7597\uff3b39-40\uff3d<\/sup>\u3002<\/p>\n

4. \u9152\u7cbe\u6027\u766b\u75eb\uff1a\u6212\u65ad\u671f\u6216\u6062\u590d\u671f\u51fa\u73b0\u766b\u75eb\u53d1\u4f5c\u5747\u5e94\u79ef\u6781\u7ed9\u4e88\u6297\u766b\u75eb\u836f\u7269\u6cbb\u7597\uff0c\u9996\u9009\u82ef\u4e8c\u6c2e\u7c7b\u836f\u7269\uff0c\u4f8b\u5982\u52b3\u62c9\u897f\u6cee\u6216\u5730\u897f\u6cee \uff3b 42 \uff3d<\/sup> \uff0c\u5fc5\u8981\u65f6\u53ef\u8054\u5408\u4f7f\u7528\u4e19\u620a\u9178\u94a0\u7f13\u91ca\u7247\u6216\u5de6\u4e59\u62c9\u897f\u5766\uff0c\u8c03\u6574\u81f3\u6700\u4f4e\u5b89\u5168\u6709\u6548\u5242\u91cf\uff0c\u51cf\u505c\u836f\u5e94\u5728\u6212\u9152\u5e76\u5b8c\u5168\u63a7\u5236\u766b\u75eb\u53d1\u4f5cl~2\u5e74\u540e\u8003\u8651\uff0c\u5e76\u6839\u636e\u60a3\u8005\u8111\u635f\u4f24\u60c5\u51b5\u9002\u5f53\u5ef6\u957f\u3002<\/p>\n

5. \u9152\u7cbe\u6027\u7cbe\u795e\u548c\u884c\u4e3a\u969c\u788d\uff1a\u9152\u7cbe\u4f1a\u5bf9\u4e2d\u67a2\u795e\u7ecf\u9012\u8d28\u7cfb\u7edf\u4ea7\u751f\u660e\u663e\u5f71\u54cd\uff0c\u5305\u62ec\u591a\u5df4\u80fa\u3001\u03b3-\u6c28\u57fa\u4e01\u9178\u548c5-\u7f9f\u8272\u80fa\u7b49\u4e2d\u67a2\u795e\u7ecf\u9012\u8d28\uff3b118\uff3d<\/sup>\u3002\u6240\u4ee5\u5e94\u79ef\u6781\u6cbb\u7597\u60a3\u8005\u7684\u7126\u8651\u3001\u6291\u90c1\u969c\u788d\uff0c\u5305\u62ec\u4f7f\u7528\u9009\u62e9\u60275-\u7f9f\u8272\u80fa\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SSRI\uff09\u5982\u6c1f\u897f\u6c40\uff0c\u62165-\u7f9f\u8272\u80fa\u548c\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNRI\uff09\u5982\u6587\u62c9\u6cd5\u8f9b\u6216\u5ea6\u6d1b\u897f\u6c40\uff3b61\uff0c96\uff3d<\/sup>\uff0c\u7814\u7a76\u4e5f\u53d1\u73b0\u7c73\u6c2e\u5e73\u7528\u4e8e\u9152\u7cbe\u4f9d\u8d56\u76f8\u5173\u6291\u90c1\u969c\u788d\u6709\u4e00\u5b9a\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff3b119\uff3d<\/sup>\u3002<\/p>\n

\u5bf9\u4e8e\u8f7b\u5ea6\u7126\u8651\u3001\u6291\u90c1\u969c\u788d\uff0c\u4e5f\u53ef\u4ee5\u8054\u5408\u4f7f\u7528\u4e2d\u6210\u836f\u5982\u8212\u809d\u89e3\u90c1\u80f6\u56ca\u3001\u4e4c\u7075\u80f6\u56ca\u7b49\uff0c\u4e5f\u6709\u4e00\u5b9a\u6548\u679c\uff0c\u800c\u4e14\u4e0d\u826f\u53cd\u5e94\u8f83\u5c11\uff0c\u4f46\u5c1a\u9700\u8981\u8fdb\u4e00\u6b65\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\uff3b120-122\uff3d<\/sup>\u3002<\/p>\n

6. CPM\uff1a\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5bf9CPM\u7684\u7597\u6548\u4e0d\u4f73\u3002\u9274\u4e8e\u4ed6\u6c40\u7c7b\u964d\u8102\u836f\u7269\u5bf9\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6027\u75c5\u53d8\u548c\u8840\u7ba1\u708e\u6027\u635f\u4f24\u7684\u4f5c\u7528\u673a\u5236\uff3b123\uff3d<\/sup>\uff0c\u8be5\u7c7b\u836f\u7269\u5982\u963f\u6258\u4f10\u4ed6\u6c40\u6216\u745e\u8212\u4f10\u4ed6\u6c40\uff0c\u5bf9\u9152\u7cbe\u6027\u8111\u767d\u8d28\u8131\u9ad3\u9798\u548c\u9152\u7cbe\u6027\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u4e5f\u53ef\u80fd\u5177\u6709\u4e00\u5b9a\u7684\u6cbb\u7597\u4f5c\u7528\uff3b124\uff3d<\/sup>\uff0c\u4f46\u5728\u7528\u836f\u8fc7\u7a0b\u4e2d\u5e94\u66f4\u52a0\u6ce8\u610f\u76d1\u6d4b\u809d\u529f\u80fd\u548c\u808c\u9176\u3002\u540c\u65f6\uff0c\u53ef\u7ed9\u4e88\u795e\u7ecf\u8425\u517b\u4fdd\u62a4\u836f\u7269\u5982\u9f20\u795e\u7ecf\u751f\u957f\u56e0\u5b50\u53ca\u827e\u5730\u82ef\u918c\u3001\u7532\u94b4\u80fa\u7b49B\u65cf\u7ef4\u751f\u7d20\u4ee5\u53ca\u4f9d\u8fbe\u62c9\u5949\u7b49\u6cbb\u7597\u3002<\/p>\n

\u63a8\u8350\u610f\u89c121\uff1a\u79ef\u6781\u975e\u80a0\u9053\u8865\u5145\u9ad8\u5242\u91cf\u7ef4\u751f\u7d20B1\u662fKS\u3001WE\u7684\u5173\u952e\u75c5\u56e0\u6cbb\u7597\uff081B\uff09\u3002\u6ce8\u5c04\u7532\u94b4\u80fa\u6cbb\u7597\u6709\u52a9\u4e8e\u63d0\u9ad8\u4e34\u5e8a\u9884\u540e\uff081D\uff09\u3002<\/p>\n

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\uff08\u516d\uff09\u5eb7\u590d\u6cbb\u7597<\/p>\n

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\u672c\u6307\u5357\u5236\u8ba2\u4e13\u5bb6\u7ec4\u540d\u5355\uff1a<\/p>\n

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\u5229\u76ca\u51b2\u7a81<\/p>\n

\u6240\u6709\u4f5c\u8005\u58f0\u660e\u4e0d\u5b58\u5728\u5229\u76ca\u51b2\u7a81<\/p>\n

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