\u672c\u6587\u4f5c\u8005\uff1a<\/p>\n
\u9648\u4f73\u6167\uff0c\u6d59\u6c5f\u7701\u676d\u5dde\u5e02\u80bf\u7624\u533b\u9662\u4e34\u5e8a\u8425\u517b\u79d1\u8425\u517b\u5e08<\/p>\n
\u5f20\u5b8b\u4e39\uff0c\u6d59\u6c5f\u7701\u676d\u5dde\u5e02\u80bf\u7624\u533b\u9662\u80bf\u7624\u7efc\u5408\u79d1\u4e8c\u75c5\u533a<\/p>\n
\u90d1\u8377\u4e91\uff0c\u6d59\u6c5f\u7701\u676d\u5dde\u5e02\u80bf\u7624\u533b\u9662\u65e5\u95f4\u75c5\u623f<\/p>\n
\u708e\u75c7\u5f88\u5e38\u89c1\uff0c\u5f88\u591a\u4eba\u89c9\u5f97\u4e0d\u662f\u5927\u95ee\u9898\u3002\u4f46\u4f60\u77e5\u9053\u5417\uff0c\u708e\u75c7\u4e0e\u591a\u79cd\u6162\u6027\u75c5\u751a\u81f3\u662f\u764c\u75c7\u6709\u5173\uff0c\u800c\u901a\u8fc7\u65e5\u5e38\u996e\u98df\u5c31\u53ef\u4ee5\u5e2e\u52a9\u8eab\u4f53\u79ef\u6781\u201c\u6297\u708e\u201d\u3002<\/p>\n
\u5f88\u591a\u6162\u6027\u75be\u75c5\u90fd\u4e0e\u708e\u75c7\u6709\u5173<\/p>\n
\u7814\u7a76\u53d1\u73b0\uff0c\u5f88\u591a\u6162\u6027\u75be\u75c5\u90fd\u4e0e\u4f53\u5185\u7684\u201c\u6162\u6027\u708e\u75c7\u201d\u6709\u5173\u3002\u8fd9\u91cc\u8bf4\u7684\u201c\u708e\u201d\uff0c\u662f\u673a\u4f53\u5728\u996e\u98df\u4e0d\u5f53\u3001\u538b\u529b\u548c\u5e94\u6fc0\u7b49\u4e9a\u5065\u5eb7\u72b6\u6001\u4e0b\uff0c\u957f\u671f\u8fc7\u91cf\u4ea7\u751f\u7684\u5404\u79cd\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u5bfc\u81f4\u7684\u6162\u6027\u708e\u75c7\uff0c\u5982\u767d\u4ecb\u7d20\u3001\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u548c\u5e72\u6270\u7d20\u7b49\u3002<\/p>\n
\u6211\u4eec\u5f80\u5f80\u6ca1\u6709\u660e\u663e\u7684\u611f\u53d7\uff0c\u4f46\u662f\u5982\u679c\u8eab\u4f53\u957f\u671f\u6e29\u6c34\u716e\u9752\u86d9\u822c\u7684\u5904\u4e8e\u708e\u75c7\u72b6\u6001\uff0c\u4f1a\u8bf1\u53d1\u73b0\u4ee3\u793e\u4f1a\u5e38\u89c1\u7684\u201c\u7ec4\u5408\u5f0f\u6162\u6027\u75c5\u201d\uff0c\u5982\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u6162\u6027\u80be\u75c5\u3001\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u4ee5\u53ca\u764c\u75c7\u7b49 \u3002<\/p>\n
\u300a\u6297\u708e\u996e\u98df\u9884\u9632\u80bf\u7624\u7684\u4e13\u5bb6\u5171\u8bc6\u300b\u4e2d\u4e5f\u6307\u51fa\uff0c\u8eab\u4f53\u6162\u6027\u4f4e\u5ea6\u708e\u75c7\u72b6\u6001\u662f\u8bf1\u53d1\u80bf\u7624\u7684\u673a\u5236\u4e4b\u4e00\u3002<\/p>\n
\u4e0d\u540c\u98df\u7269\u4f1a\u5f71\u54cd\u8eab\u4f53\u708e\u75c7\uff01<\/p>\n
\u81b3\u98df\u4e2d\u7684\u5404\u79cd\u751f\u7269\u6d3b\u6027\u6210\u5206\uff08\u5305\u62ec\u80fd\u91cf\u4e0e\u8425\u517b\u7d20\uff09\u53ef\u5f71\u54cd\u4eba\u4f53\u5185\u708e\u75c7\u53cd\u5e94\u8fc7\u7a0b\u3002\u6bd4\u5982\u2014\u2014<\/p>\n
1.\u9ad8\u7cd6\u53ca\u7cbe\u5236\u78b3\u6c34\u98df\u7269<\/p>\n
\u5982\u86cb\u7cd5\u3001\u997c\u5e72\u3001\u996e\u6599\u7b49\u9ad8\u7cd6\u98df\u7269\u4ee5\u53ca\u767d\u7c73\u3001\u767d\u9992\u5934\u3001\u767d\u9762\u5305\u3001\u6cb9\u6761\u3001\u5e74\u7cd5\u3001\u7c73\u7c89\u7b49\u7cbe\u5236\u78b3\u6c34\u98df\u7269\u5728\u4eba\u4f53\u5185\u4f1a\u4ee3\u8c22\u4e3a\u8461\u8404\u7cd6\u3002<\/p>\n
\u7814\u7a76\u53d1\u73b0\uff0c\u8fc7\u91cf\u7684\u8461\u8404\u7cd6\u5c31\u50cf\u7ed9\u7ec6\u80de\u52a0\u6ee1\u4e86\u201c\u6cb9\u201d\uff0c\u8bf1\u4f7f\u7ebf\u7c92\u4f53\u4ee5\u5927\u529f\u7387\u8fd0\u8f6c\uff0c\u4ea7\u751f\u7684\u6d3b\u6027\u6c27\uff08ROS\uff09\u4fc3\u8fdb\u8f85\u52a9T\u7ec6\u80de17\uff08Th17\uff09\u751f\u6210\uff0c\u5bfc\u81f4\u514d\u75ab\u7cfb\u7edf\u8fdb\u4e00\u6b65\u5931\u8861\uff0c\u52a0\u5267\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002<\/p>\n<\/p>\n
\u5065\u5eb7\u65f6\u62a5\u6bdb\u5706\u5706\/\u6444<\/p>\n
2.\u7ea2\u8089\u548c\u6df1\u52a0\u5de5\u8089\u7c7b<\/p>\n
\u6d88\u5316\u7ea2\u8089\u7684\u8fc7\u7a0b\u4e2d\uff0c\u4f1a\u4ea7\u751f\u4e9a\u94c1\u79bb\u5b50\u548cN-\u4e9a\u785d\u57fa\u5316\u5408\u7269\uff0c\u8bf1\u53d1DNA\u4e92\u8865\u78b1\u57fa\u5bf9\u95f4\u7684\u4ea4\u8054\uff0c\u5728\u708e\u75c7\u53cd\u590d\u7684\u60c5\u51b5\u4e0b\u542f\u52a8\u7ec6\u80de\u764c\u53d8\u8fdb\u7a0b\u3002<\/p>\n
\u70df\u718f\u8089\u3001\u70e4\u8089\u3001\u706b\u817f\u3001\u9999\u80a0\u3001\u57f9\u6839\u7b49\u8089\u7c7b\u98df\u54c1\u5728\u6df1\u52a0\u5de5\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u4f1a\u4ea7\u751fN-\u4e9a\u785d\u57fa\u5316\u5408\u7269\u3001\u591a\u73af\u82b3\u70c3\u7c7b\u548c\u6742\u73af\u80fa\u7c7b\u7b49\u6709\u5bb3\u7269\u8d28\uff0c\u8fc7\u91cf\u98df\u7528\u4f1a\u63d0\u9ad8\u4eba\u4f53\u7684\u6c27\u5316\u5e94\u6fc0\u6c34\u5e73\uff0c\u4fc3\u8fdb\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n
\u4e14\u6df1\u52a0\u5de5\u8089\u7c7b\u542b\u76d0\u91cf\u5f80\u5f80\u5f88\u9ad8\uff0c\u9ad8\u76d0\u6444\u5165\u5df2\u7ecf\u88ab\u8bc1\u5b9e\u80fd\u591f\u4fc3\u8fdb\u4fc3\u708e\u7684Th17\u7ec6\u80de\u5206\u5316\uff0c\u52a0\u901f\u81ea\u8eab\u514d\u75ab\u6027\u8111\u810a\u9ad3\u708e\uff08EAE\uff09\u7684\u53d1\u5c55\u3002<\/p>\n
3.\u9ad8\u6cb9\u98df\u7269<\/p>\n
n-6\u591a\u4e0d\u9971\u548c\u8102\u80aa\u9178\u4f1a\u5728\u591a\u79cd\u9176\u7684\u50ac\u5316\u4e0b\u4ea7\u751f\u81f4\u708e\u7684\u524d\u5217\u817a\u7d20\uff08PGs\uff09\u3001\u8840\u6813\u7d20\u548c\u767d\u4e09\u70ef\uff08lt\uff09\u7b49\u3002\u5b83\u4eec\u4f1a\u4f5c\u4e3a\u708e\u75c7\u4ecb\u8d28\u548c\u8c03\u8282\u56e0\u5b50\u4fc3\u8fdb\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n
n-6\u591a\u4e0d\u9971\u548c\u8102\u80aa\u9178\u5e38\u89c1\u4e8e\u5bb6\u5ead\u70f9\u996a\u7528\u690d\u7269\u6cb9\uff0c\u542b\u91cf\u662f\u7531\u591a\u5230\u5c11\u6392\u5217\u4e3a\uff1a\u7389\u7c73\u6cb9\uff1e\u829d\u9ebb\u6cb9\uff1e\u8475\u82b1\u7c7d\u6cb9\uff1e\u5927\u8c46\u6cb9\uff1e\u7c73\u7ce0\u6cb9\uff1e\u82b1\u751f\u6cb9\uff1e\u83dc\u7c7d\u6cb9\u3002<\/p>\n
4.\u6df1\u52a0\u5de5\u7684\u98df\u7269<\/p>\n
\u4e00\u4e9b\u6df1\u52a0\u5de5\u7684\u98df\u7269\uff0c\u5982\u997c\u5e72\u3001\u9762\u5305\u3001\u86cb\u7cd5\u3001\u5976\u8336\u7b49\u96f6\u98df\u4e2d\u5f80\u5f80\u542b\u6709\u53cd\u5f0f\u8102\u80aa\u9178\u3002\u770b\u5230\u914d\u6599\u8868\u91cc\u6709\u201c\u690d\u8102\u672b\u3001\u7cbe\u70bc\u690d\u7269\u6cb9\u3001\u6c22\u5316\u690d\u7269\u6cb9\u3001\u6c22\u5316\u8d77\u9165\u6cb9\u3001\u9165\u6cb9\u3001\u4eba\u9020\u5976\u6cb9\u3001\u690d\u7269\u5976\u6cb9\u3001\u4eba\u9020\u9ec4\u6cb9\u201d\u7b49\u5b57\u6837\u7684\u5c31\u8981\u8b66\u60d5\u3002<\/p>\n
\u4e2d\u56fd\u5c45\u6c11\u81b3\u98df\u8425\u517b\u7d20\u53c2\u8003\u6444\u5165\u91cf\u5efa\u8bae2\u5c81\u4ee5\u4e0a\u513f\u7ae5\u548c\u6210\u4eba\u81b3\u98df\u4e2d\u53cd\u5f0f\u8102\u80aa\u9178\u7684\u6700\u9ad8\u9650\u91cf\u4e3a2\u514b\u3002\u6444\u5165\u8fc7\u591a\u7684\u53cd\u5f0f\u8102\u80aa\u9178\u4f1a\u52a0\u91cd\u8eab\u4f53\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u4fc3\u8fdb\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u53d1\u751f\u3002<\/p>\n
\u8fd9\u6837\u5403\u662f\u5728\u7ed9\u8eab\u4f53\u201c\u6297\u708e\u201d\uff01<\/p>\n
\u6297\u708e\u996e\u98df\u5728\u6539\u5584\u4f53\u5185\u708e\u75c7\u5fae\u73af\u5883\u65b9\u9762\u6709\u660e\u663e\u4f18\u52bf\uff0c\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u533b\u5b66\u9662\u7684\u7814\u7a76\u8005\u7684\u4e00\u9879\u7814\u7a76\u6210\u679c\u8868\u660e\uff0c\u6297\u708e\u996e\u98df\u5728\u4ec5\u4ec5\u4e24\u5468\u5185\uff0c\u5c31\u80fd\u6539\u5584\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u60a3\u8005\u7684\u5173\u8282\u538b\u75db\u548c\u80bf\u80c0\u7b49\u75c7\u72b6\u3002<\/p>\n
2021\u5e74\u7684\u4e00\u7bc7\u6587\u7ae0\uff0c\u7814\u7a76\u56e2\u961f\u4ece3581\u9879\u7814\u7a76\u4e2d\u7b5b\u9009\u51fa\u516d\u5927\u7c7b\u3001\u517188\u79cd\u5177\u6709\u6297\u708e\u6548\u679c\u7684\u98df\u7269\u3002\u5177\u4f53\u53ef\u603b\u7ed3\u4e3a\u2014\u2014<\/p>\n<\/p>\n
\u56fe\u81ea\u676d\u5dde\u5e02\u80bf\u7624\u533b\u9662<\/p>\n
1.\u852c\u83dc\u7c7b<\/p>\n
\u83e0\u83dc\u7b49\u5404\u79cd\u6df1\u7eff\u53f6\u852c\u83dc\uff1b\u80e1\u841d\u535c\u3001\u897f\u7ea2\u67ff\u3001\u7d2b\u6d0b\u8471\u3001\u6d77\u5e26\u7b49\u6df1\u8272\u852c\u83dc\uff1b\u7279\u522b\u662f\u5341\u5b57\u82b1\u79d1\u852c\u83dc\u897f\u5170\u82b1\u3001\u5377\u5fc3\u83dc\u3001\u7fbd\u8863\u7518\u84dd\u3001\u5927\u767d\u83dc\u3001\u83dc\u82b1\u7b49\u3002<\/p>\n
\u6df1\u8272\u852c\u83dc\u3001\u80e1\u841d\u535c\u3001\u5357\u74dc\u7b49\u9ec4\u6a59\u8272\u98df\u7269\u4e2d\u5bcc\u542bVc\u3001\u03b2-\u80e1\u841d\u535c\u7d20\uff0c\u77ff\u7269\u8d28\u3001\u81b3\u98df\u7ea4\u7ef4\u4ee5\u53ca\u6297\u6c27\u5316\u7684\u690d\u7269\u5316\u5b66\u7269\u3002<\/p>\n
2.\u6c34\u679c\u7c7b<\/p>\n
\u7315\u7334\u6843\u3001\u6843\u674f\u674e\u3001\u6a58\u5b50\u3001\u67da\u5b50\u3001\u6a31\u6843\u3001\u5c0f\u756a\u8304\u7b49\u3002\u7279\u522b\u63a8\u8350\u6d46\u679c\u7c7b\u6c34\u679c\uff0c\u6bd4\u5982\u6811\u8393\u3001\u84dd\u8393\u3001\u8349\u8393\u7b49\uff0c\u5bcc\u542b\u6297\u6c27\u5316\u7684\u82b1\u9752\u7d20\u548c\u591a\u915a\u7c7b\u7269\u8d28\uff0c\u8fd9\u4e24\u79cd\u7269\u8d28\u90fd\u6709\u5229\u4e8e\u964d\u4f4e\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n
3.\u5168\u8c37\u7269\u548c\u6742\u8c46\u7c7b<\/p>\n
\u5168\u8c37\u7269\u5305\u542b\u7c97\u52a0\u5de5\u7684\u7cd9\u7c73\u3001\u71d5\u9ea6\u7c73\u3001\u9ed1\u7c73\u3001\u6742\u7cae\u9762\u7b49\u548c\u6dc0\u7c89\u8c46\u7c7b\uff0c\u6bd4\u5982\u7ea2\u8c46\u3001\u7eff\u8c46\u3001\u9e70\u5634\u8c46\u3001\u82b8\u8c46\u7b49\u3002<\/p>\n
\u76f8\u8f83\u4e8e\u7cbe\u5236\u78b3\u6c34\uff0c\u5168\u8c37\u7269\u542b\u6709\u66f4\u591a\u7684\u86cb\u767d\u8d28\u3001B\u65cf\u7ef4\u751f\u7d20\u3001\u77ff\u7269\u8d28\u548c\u81b3\u98df\u7ea4\u7ef4\uff0c\u8fd8\u6709\u4e00\u4e9b\u6297\u6c27\u5316\u7684\u690d\u7269\u5316\u5b66\u7269\u5982\u82b1\u9752\u7d20\u3001\u03b2-\u80e1\u841d\u535c\u7d20\u3001\u5355\u5b81\u7b49\uff0c\u90fd\u662f\u6709\u5229\u4e8e\u964d\u4f4e\u708e\u75c7\u53cd\u5e94\u7684\u3002<\/p>\n
4.\u9999\u8f9b\u6599\u7c7b<\/p>\n
\u4e2d\u5f0f\u70f9\u8c03\u5e38\u7528\u9999\u8f9b\u6599\u8471\u59dc\u849c\u3001\u8089\u6842\u3001\u516b\u89d2\u9ed1\u80e1\u6912\u7b49\u5177\u6709\u5f88\u5f3a\u7684\u6297\u6c27\u5316\u3001\u6297\u708e\u4f5c\u7528\uff0c\u5176\u4ed6\u7684\u9999\u8f9b\u6599\u5982\u59dc\u9ec4\u3001\u8ff7\u8fed\u9999\u7b49\u897f\u9910\u70f9\u996a\u4f7f\u7528\u8f83\u591a\u3002\u7eff\u8336\uff0c\u5bcc\u542b\u8336\u591a\u915a\u7b49\u6297\u6c27\u5316\u7269\u8d28\uff0c\u4e5f\u662f\u6297\u708e\u6548\u679c\u4e00\u6d41\u3002<\/p>\n
5.\u5bcc\u542bn-3\u591a\u4e0d\u9971\u548c\u8102\u80aa\u9178\u7684\u98df\u7269<\/p>\n
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