{"id":44602,"date":"2024-12-05T05:11:11","date_gmt":"2024-12-05T05:11:11","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=44602"},"modified":"2024-12-05T05:11:11","modified_gmt":"2024-12-05T05:11:11","slug":"%e6%b7%ab%e7%be%8a%e8%97%bf%e7%b4%a0%e7%9a%84%e8%8d%af%e7%90%86%e4%bd%9c%e7%94%a8%e5%8f%8a%e6%9c%ba%e5%88%b6%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=44602","title":{"rendered":"\u6deb\u7f8a\u85ff\u7d20\u7684\u836f\u7406\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"<\/p>\n<p>\u6deb\u7f8a\u85ffEpimedii Folium\u53c8\u540d\u4ed9\u7075\u813e\u3001\u521a\u524d\uff0c\u5177\u6709\u8865\u80be\u58ee\u9633\u3001\u5f3a\u7b4b\u5065\u9aa8\u548c\u795b\u98ce\u795b\u6e7f\u7684\u529f\u6548\uff0c\u662f\u4e34\u5e8a\u5e38\u7528\u7684\u4e2d\u836f\u6750\u3002\u73b0\u4ee3\u836f\u7406\u5b66\u7814\u7a76\u8868\u660e\uff0c\u6deb\u7f8a\u85ff\u5177\u6709\u6297\u708e\u3001\u6297\u6c27\u5316\u3001\u6297\u9aa8\u8d28\u758f\u677e\u3001\u6297\u80bf\u7624\u3001\u6297\u6291\u90c1\u7b49\u4f5c\u7528<sup>[1]<\/sup>\u3002\u6deb\u7f8a\u85ff\u7d20\u662f\u4e00\u79cd\u6765\u81ea\u6deb\u7f8a\u85ff\u5c5e\u690d\u7269\u4e2d\u6deb\u7f8a\u85ff\u82f7\u6c34\u89e3\u800c\u6210\u7684\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u5f02\u620a\u4e8c\u70ef\u7c7b\u9ec4\u916e\u884d\u751f\u7269<sup>[2]<\/sup>\u3002\u73b0\u4ee3\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u53d1\u73b0\uff0c\u5176\u5177\u6709\u5e7f\u6cdb\u7684\u751f\u7269\u6d3b\u6027\uff0c\u5982\u9aa8\u4fdd\u62a4\u3001\u795e\u7ecf\u4fdd\u62a4\u3001\u5fc3\u8840\u7ba1\u4fdd\u62a4\u3001\u6297\u764c\u3001\u6297\u708e\u53ca\u514d\u75ab\u8c03\u8282\u7b49\u836f\u7406\u4f5c\u7528<sup>[3-5]<\/sup>\u3002\u5176\u7ed3\u6784\u542b\u6709\u7a20\u5408\u82ef\u5e76\u5421\u5583\u73af\u9aa8\u67b6\uff0c\u5206\u5b50\u5f0f\u4e3aC<sub>21<\/sub>H<sub>20<\/sub>O<sub>6<\/sub>\uff0c\u76f8\u5bf9\u5206\u5b50\u8d28\u91cf\u4e3a368.4\u3002\u7531\u4e8e\u6deb\u7f8a\u85ff\u7d20\u5177\u6709\u8102\u6eb6\u6027\u9ad8\u3001\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u4f4e\u7b49\u7f3a\u70b9\uff0c\u4f7f\u5176\u5728\u4e34\u5e8a\u4e0a\u5e94\u7528\u53d7\u5230\u4e00\u5b9a\u9650\u5236<sup>[6]<\/sup>\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5176\u5e7f\u6cdb\u7684\u836f\u7406\u6d3b\u6027\uff0c\u6deb\u7f8a\u85ff\u7d20\u9010\u6e10\u6210\u4e3a\u4e00\u79cd\u65b0\u7684\u6f5c\u5728\u6cbb\u7597\u5242\uff0c\u5438\u5f15\u4e86\u4f17\u591a\u7814\u7a76\u8005\u7684\u5173\u6ce8\u3002\u672c\u6587\u9488\u5bf9\u6deb\u7f8a\u85ff\u7d20\u76f8\u5173\u7684\u6700\u65b0\u7814\u7a76\u52a8\u6001\uff0c\u5bf9\u5176\u836f\u7406\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76\u8fdb\u884c\u7efc\u8ff0\uff0c\u4e3a\u8fdb\u4e00\u6b65\u5f00\u53d1\u548c\u5229\u7528\u63d0\u4f9b\u7406\u8bba\u4f9d\u636e\u3002<\/p>\n<p>1 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\u5bf9\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\u7684\u4f5c\u7528\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u662f\u6307\u7d2f\u53ca\u8840\u6db2\u3001\u9aa8\u9ad3\u3001\u6dcb\u5df4\u53ca\u6dcb\u5df4\u7cfb\u7edf\uff0c\u5e76\u6700\u7ec8\u5bfc\u81f4\u9020\u8840\u969c\u788d\u7684\u4e00\u7cfb\u5217\u6076\u6027\u75be\u75c5\u3002\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08acute myelogenous leukemia\uff0cAML\uff09\u662f\u4e00\u79cd\u6e90\u4e8e\u9ad3\u7cfb\u5e72\u7ec6\u80de\u524d\u4f53\u7684\u6076\u6027\u80bf\u7624\uff0c\u5176\u4e3b\u8981\u81f4\u75c5\u56e0\u7d20\u662f\u5bfc\u81f4\u80bf\u7624\u53d8\u5316\u548c\u514b\u9686\u6027\u589e\u6b96\u7684\u57fa\u56e0\u53d8\u5f02<sup>[8]<\/sup>\u3002\u76ee\u524dAML\u7684\u6cbb\u7597\u65b9\u6cd5\u4ecd\u4ee5\u5316\u5b66\u836f\u4e3a\u4e3b\u3002\u7136\u800c\uff0c\u968f\u7740\u5bf9\u8be5\u75be\u75c5\u57fa\u56e0\u53d8\u5f02\u673a\u5236\u7684\u6df1\u5165\u63a2\u7a76\uff0c\u65b0\u7597\u6cd5\u7684\u7814\u53d1\u4e3a\u6539\u5584\u60a3\u8005\u9884\u540e\u63d0\u4f9b\u4e86\u5e0c\u671b\u3002\u6709\u7814\u7a76\u8868\u660e\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\uff08cyclin-dependent kinases\uff0cCDK\uff09\u88ab\u8ba4\u4e3a\u662f\u764c\u75c7\u6cbb\u7597\u4e2d\u6709\u5438\u5f15\u529b\u7684\u9776\u70b9\uff0c\u800cCDK2\u662f\u80bf\u7624\u7ec6\u80de\u4e2d\u6deb\u7f8a\u85ff\u7d20\u7684\u76f4\u63a5\u9776\u6807<sup>[9]<\/sup>\uff0c\u6deb\u7f8a\u85ff\u7d20\u4e00\u65b9\u9762\u53ef\u4ee5\u4e0eCDK2\u76f8\u4e92\u4f5c\u7528\u5e76\u5e72\u6270CDK2\/\u7ec6\u80de\u5468\u671f\u86cb\u767dE\u590d\u5408\u7269\u7684\u5f62\u6210\uff0c\u5bfc\u81f4CDK2\u6d3b\u6027\u4e0b\u8c03\uff1b\u53e6\u4e00\u65b9\u9762\u901a\u8fc7\u8c03\u8282microRNA-597\u7684\u8868\u8fbe\u964d\u4f4eCDK2 mRNA\u7684\u7a33\u5b9a\u6027\u548c\u7ffb\u8bd1\u6548\u7387\uff0c\u8fdb\u800c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96\u5e76\u4fc3\u8fdb\u5176\u51cb\u4ea1<sup>[10]<\/sup>\u3002Wnt\u4fe1\u53f7\u4f20\u5bfc\u901a\u8def\u662f\u7ec6\u80de\u5206\u5316\u589e\u6b96\u7684\u91cd\u8981\u73af\u8282\uff0c\u800cWnt\u4fe1\u53f7\u9014\u5f84\u7684\u91cd\u8981\u56e0\u5b50\u03b2-\u8fde\u73af\u86cb\u767d\uff08\u03b2-catenin\uff09\u662f\u767d\u8840\u75c5\u7ec6\u80de\u751f\u7269\u4fe1\u53f7\u4ece\u80de\u819c\u8f6c\u8fd0\u5230\u80de\u6d46\u7684\u91cd\u8981\u4fe1\u4f7f<sup>[11]<\/sup>\u3002\u56e0\u6b64\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u4ee5\u901a\u8fc7\u6291\u5236Wnt\/\u03b2-catenin\u4fe1\u53f7\u901a\u8def\u53ca\u5176\u4e0b\u6e38\u76f8\u5173\u57fa\u56e0\u8868\u8fbe\u88c2\u89e3\u591a\u817a\u82f7\u4e8c\u78f7\u9178\u6838\u7cd6\u805a\u5408\u9176\uff08poly ADP-ribose polymerase\uff0cPARP\uff09\uff0c\u8bf1\u5bfc\u4eba\u9ad3\u7cfb\u767d\u8840\u75c5KG-1a\u7ec6\u80de\u7684\u51cb\u4ea1<sup>[12]<\/sup>\u3002\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08chronic myeloid leukemia\uff0cCML\uff09\u662f\u4e00\u79cd\u4ee5\u8d39\u57ce\u67d3\u8272\u4f53\u4e3a\u7279\u5f81\u7684\u514b\u9686\u6027\u9aa8\u9ad3\u589e\u751f\u6027\u75be\u75c5\u3002\u5df2\u6709\u7814\u7a76\u8bc1\u5b9e\uff0c\u6deb\u7f8a\u85ff\u7d20\u4e3b\u8981\u901a\u8fc7\u4f5c\u7528\u4e8e\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08mitogen-activated protein kinases\uff0cMAPK\uff09\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3001\u963b\u6ede\u7ec6\u80de\u5468\u671f\u7684\u8fdb\u884c\uff0c\u6d3b\u6027\u6c27\u80fd\u591f\u4f5c\u4e3a\u4e0a\u6e38\u8c03\u63a7\u56e0\u5b50\u53c2\u4e0e\u5bf9MAPK\u5bb6\u65cfc-Jun\u6c28\u57fa\u672b\u7aef\u6fc0\u9176\uff08c-Jun N-terminal<br \/>\nkinase\uff0cJNK\uff09\u4fe1\u53f7\u901a\u8def\u7684\u8c03\u63a7<sup>[13]<\/sup>\u3002\u5728\u4ee5\u4eba\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5K562\u7ec6\u80de\u4e3a\u6a21\u578b\u6765\u63a2\u8ba8\u6deb\u7f8a\u85ff\u7d20\u6291\u5236\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u7684\u673a\u5236\u4e2d\uff0c\u53d1\u73b0\u6deb\u7f8a\u85ff\u7d20\u53ef\u901a\u8fc7\u6fc0\u6d3b\u6d3b\u6027\u6c27\/JNK\/c-Jun\u4fe1\u53f7\u901a\u8def\u53d1\u6325\u6291\u5236\u8840\u6db2\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u7684\u4f5c\u7528<sup>[14]<\/sup>\u3002\u6b64\u5916\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u4ee5\u901a\u8fc7\u523a\u6fc0\u8840\u6db2\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u6d3b\u6027\u6c27\u7684\u540c\u65f6\u6fc0\u6d3bJanus\u6fc0\u91762\uff08Janus kinase 2\uff0cJAK2\uff09\/\u4fe1\u53f7\u8f6c\u5bfc\u548c\u8f6c\u5f55\u6fc0\u6d3b\u86cb\u767d3\uff08signal transducer and activator<br \/>\nof transcription 3\uff0cSTAT3\uff09\/p21\u901a\u8def\uff0c\u8fdb\u800c\u6291\u5236\u764c\u7ec6\u80de\u7684\u589e\u6b96\u3001\u8bf1\u5bfc\u764c\u7ec6\u80de\u5468\u671f\u963b\u6ede\u5e76\u4fc3\u8fdb\u5176\u51cb\u4ea1<sup>[15]<\/sup>\u3002Hou\u7b49<sup>[16]<\/sup>\u7814\u7a76\u53d1\u73b0\u6deb\u7f8a\u85ff\u7d20\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u767d\u7ec6\u80de\u4ecb\u7d20-6\uff08interleukin-6\uff0cIL-6\uff09\/JAK2\/STAT3\u4fe1\u53f7\u901a\u8def\uff0c\u964d\u4f4e\u767d\u8840\u75c5\u5c0f\u9f20\u813e\u810f\u548c\u809d\u810f\u4e2dIL-6\u3001JAK2\u548cSTAT3\u7684mRNA\u8868\u8fbe\uff0c\u540c\u65f6\u589e\u52a0\u6291\u5236\u6297\u51cb\u4ea1\u86cb\u767dB\u6dcb\u5df4\u7ec6\u80de\u7624-2\uff08B-cell lymphoma-2\uff0cBcl-2\uff09\u548c\u4fc3\u51cb\u4ea1\u86cb\u767dBcl-2\u76f8\u5173X\u86cb\u767d\uff08Bcl-2 associated X protein\uff0cBax\uff09\u7684\u8868\u8fbe\uff0c\u4fc3\u8fdb\u767d\u8840\u75c5\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u56e0\u6b64\uff0c\u6deb\u7f8a\u85ff\u7d20\u6709\u671b\u6210\u4e3a\u4e00\u79cd\u5b89\u5168\u6709\u6548\u7684\u6297\u767d\u8840\u75c5\u5019\u9009\u836f\u7269\u30021.2 \u5bf9\u809d\u764c\u7684\u4f5c\u7528\u7532\u80ce\u86cb\u767d\u662f\u4e00\u79cd\u7cd6\u86cb\u767d\uff0c\u5728\u5065\u5eb7\u80ce\u513f\u809d\u810f\u548c\u5375\u9ec4\u56ca\u4e2d\u4ea7\u751f<sup>[17]<\/sup>\u3002\u7814\u7a76\u8868\u660e\uff0c\u7ec6\u80de\u5185\u7684\u7532\u80ce\u86cb\u767d\u4e0d\u4ec5\u53ef\u4fc3\u8fdb\u809d\u7ec6\u80de\u764c\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u8fd8\u80fd\u6291\u5236\u7ec6\u80de\u51cb\u4ea1\u3002Li\u7b49<sup>[18]<\/sup>\u7814\u7a76\u53d1\u73b0\uff0cp53\u8f6c\u5f55\u56e0\u5b50\u7684\u9776\u57fa\u56e0\u662f\u7532\u80ce\u86cb\u767d\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u901a\u8fc7\u6291\u5236\u809d\u764c\u7ec6\u80de\u4e2d\u7532\u80ce\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u6709\u6548\u6291\u5236\u7ec6\u80de\u751f\u957f\u5e76\u4fc3\u8fdb\u7ec6\u80de\u51cb\u4ea1\u3002\u5176\u4f5c\u7528\u673a\u5236\u6d89\u53ca\u963b\u65ad\u5c0f\u9f20\u53cc\u5fae\u4f53\u6269\u589e\u57fa\u56e02\uff08murine double minute 2\uff0cMDM2\uff09\u764c\u57fa\u56e0\u4ecb\u5bfc\u7684p53\u6cdb\u7d20\u5316\u964d\u89e3\uff0c\u4ece\u800c\u63d0\u9ad8p53\u7684\u7a33\u5b9a\u6027\u3002p53\u86cb\u767d\u6c34\u5e73\u7684\u5347\u9ad8\u8fdb\u4e00\u6b65\u6291\u5236\u7532\u80ce\u86cb\u767d\u542f\u52a8\u5b50\u7684\u6d3b\u6027\uff0c\u6700\u7ec8\u5b9e\u73b0\u7532\u80ce\u86cb\u767d\u8868\u8fbe\u4e0b\u8c03\uff0c\u4fc3\u8fdb\u809d\u764c\u7ec6\u80de\u51cb\u4ea1\uff0c\u6291\u5236\u809d\u764c\u7ec6\u80de\u589e\u6b96\u7684\u6548\u679c\u3002\u5728\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u836f\u7269\u4e2d\uff0c\u7d22\u62c9\u83f2\u5c3c\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u4f46\u5176\u5e94\u7528\u9762\u4e34\u5e94\u7b54\u7387\u4f4e\u548c\u590d\u53d1\u7387\u9ad8\u7684\u95ee\u9898\u3002\u7814\u7a76\u8868\u660e\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u4ee5\u901a\u8fc7\u7ebf\u7c92\u4f53\u9014\u5f84\u589e\u5f3a\u7d22\u62c9\u83f2\u5c3c\u7684\u8bf1\u5bfc\u51cb\u4ea1\u4f5c\u7528\uff0c\u4ece\u800c\u589e\u52a0\u7d22\u62c9\u975e\u5c3c\u8bf1\u5bfc\u7684\u809d\u7ec6\u80de\u51cb\u4ea1\u3002Bcl-2\u5bb6\u65cf\u86cb\u767d\uff0c\u5305\u62ec\u4fc3\u51cb\u4ea1\u86cb\u767dBax\u548c\u6297\u51cb\u4ea1\u86cb\u767dBcl-2\uff0c\u662f\u8c03\u8282\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\u53d8\u5316\u7684\u91cd\u8981\u56e0\u5b50\uff0c\u5728\u7ebf\u7c92\u4f53\u51cb\u4ea1\u9014\u5f84\u4e2d\u5177\u6709\u5173\u952e\u4f5c\u7528<sup>[19]<\/sup>\u3002\u8fd9\u4e9b\u86cb\u767d\u8d28\u7684\u76f8\u5bf9\u8868\u8fbe\u6c34\u5e73\u5f71\u54cd\u7740\u7ec6\u80de\u7684\u751f\u5b58\u4e0e\u51cb\u4ea1\uff0c\u56e0\u6b64\uff0c\u901a\u8fc7\u8c03\u8282\u8fd9\u4e9b\u86cb\u767d\u8d28\u7684\u8868\u8fbe\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u80fd\u8fdb\u4e00\u6b65\u589e\u5f3a\u7d22\u62c9\u83f2\u5c3c\u7684\u6297\u80bf\u7624\u6548\u679c\u3002\u6709\u7814\u7a76\u8868\u660e\uff0c\u5355\u72ec\u4f7f\u7528\u6deb\u7f8a\u85ff\u7d20\u6216\u7d22\u62c9\u83f2\u5c3c\u5747\u80fd\u964d\u4f4e\u4eba\u809d\u764cHepG2\u548cHuh-7\u7ec6\u80de\u4e2dBcl-2\u7684\u6c34\u5e73\uff0c\u5e76\u63d0\u9ad8Bax\u7684\u6c34\u5e73\u3002\u5f53\u4e8c\u8005\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u6548\u679c\u66f4\u660e\u663e\uff0c\u4e14\u534a\u80f1\u6c28\u9178\u5929\u51ac\u6c28\u9178\u86cb\u767d\u9176-3\uff08cystein-asparate<br \/>\nprotease-3\uff0cCaspase-3\uff09\u3001Caspase-9\u7684\u88c2\u89e3\u6d3b\u6027\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u548c\u5355\u7528\u7ec4<sup>[20]<\/sup>\u3002\u9ecf\u7740\u6591\u6fc0\u9176\u4f5c\u4e3a\u80de\u5185\u5916\u4fe1\u53f7\u4f20\u5bfc\u7684\u4e2d\u67a2\u4e4b\u4e00\uff0c\u53ef\u4ee5\u6fc0\u6d3b\u80de\u5185\u7ec6\u80de\u5916\u8c03\u8282\u86cb\u767d\u6fc0\u9176\uff08extracellular regulated protein kinase\uff0cERK\uff09\/cyclin D1\u53ca\u86cb\u767d\u6fc0\u9176B\uff08protein kinase B\uff0cAkt\uff09\/\u54fa\u4e73\u52a8\u7269\u96f7\u5e15\u9709\u7d20\u9776\u86cb\u767d\uff08mammalian target of rapamycin\uff0cmTOR\uff09\u7b49\u4fe1\u53f7\u901a\u8def\uff0c\u8fbe\u5230\u591a\u9776\u70b9\u3001\u591a\u901a\u8def\u8c03\u8282\u7ec6\u80de\u751f\u957f\u7684\u4f5c\u7528<sup>[21]<\/sup>\u3002\u5728\u5bf9\u6deb\u7f8a\u85ff\u7d20\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u7684\u6700\u65b0\u7814\u7a76\u4e2d\u53d1\u73b0\uff0c\u7ebf\u7c92\u4f53\u81ea\u566c\u5bf9\u764c\u7ec6\u80de\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u901a\u8fc7\u8c03\u63a7PTEN\u8bf1\u5bfc\u6fc0\u91761\uff08PTEN-induced putative kinase 1\uff0cPINK1\uff09\/Parkin\u4fe1\u53f7\u901a\u8def\u6291\u5236\u7ebf\u7c92\u4f53\u81ea\u566c\uff0c\u5e76\u4e14\u4e0e\u81ea\u566c\/\u7ebf\u7c92\u4f53\u81ea\u566c\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u53ef\u4ee5\u534f\u540c\u589e\u5f3a\u6deb\u7f8a\u85ff\u7d20\u7684\u6297\u80bf\u7624\u6548\u679c<sup>[22]<\/sup>\u30021.3 \u5bf9\u524d\u5217\u817a\u764c\u7684\u4f5c\u7528\u524d\u5217\u817a\u764c\u662f\u4e00\u79cd\u53d1\u75c5\u7387\u6781\u9ad8\u7684\u81f4\u547d\u6076\u6027\u80bf\u7624\uff0c\u5728\u6211\u56fd\u7537\u6027\u4eba\u7fa4\u4e2d\uff0c\u5176\u53d1\u75c5\u7387\u9010\u5e74\u589e\u52a0<sup>[23]<\/sup>\u3002\u76ee\u524d\uff0c\u9488\u5bf9\u524d\u5217\u817a\u764c\u7684\u6cbb\u7597\u65b9\u6cd5\u76f8\u5bf9\u5355\u4e00\uff0c\u96c4\u6fc0\u7d20\u5265\u593a\u7597\u6cd5\u662f\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u524d\u5217\u817a\u764c\u60a3\u8005\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\u3002\u5c3d\u7ba1\u5316\u7597\u7684\u521d\u59cb\u6cbb\u7597\u6548\u679c\u8f83\u4e3a\u7406\u60f3\uff0c\u4f46\u60a3\u8005\u5bb9\u6613\u4ea7\u751f\u8010\u836f\u6027\u548c\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u63a2\u7d22\u4e2d\u836f\u5bf9\u524d\u5217\u817a\u764c\u7684\u6cbb\u7597\u65b9\u6cd5\u8feb\u5728\u7709\u776b\u3002\u6301\u7eed\u6027\u7684\u96c4\u6fc0\u7d20\u53d7\u4f53\uff08androgen receptor\uff0cAR\uff09\u4fe1\u53f7\u4f20\u5bfc\u88ab\u8ba4\u4e3a\u662f\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u8fdb\u5c55\u7684\u5173\u952e\u56e0\u7d20\u3002\u7814\u7a76\u8868\u660e\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u4eba\u524d\u5217\u817a\u764c\u7ec6\u80de\u4e2d\u7684AR\u4fe1\u53f7\uff0c\u53d1\u6325\u6297\u524d\u5217\u817a\u764c\u7684\u4f5c\u7528<sup>[24]<\/sup>\u3002\u8fd9\u4e00\u673a\u5236\u4e3a\u524d\u5217\u817a\u764c\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002Hu\u7b49<sup>[25]<\/sup>\u901a\u8fc7\u5bf9\u6deb\u7f8a\u85ff\u7d20\u7684\u6297\u524d\u5217\u817a\u764c\u673a\u5236\u7814\u7a76\uff0c\u53d1\u73b0\u6deb\u7f8a\u85ff\u7d20\u53ef\u663e\u8457\u6291\u5236\u524d\u5217\u817a\u764c\u7ec4\u7ec7\u4e2d\u7ec6\u80de\u5468\u671f\u8c03\u8282\u86cb\u767d-67\u7684\u8868\u8fbe\uff0c\u8868\u660e\u6deb\u7f8a\u85ff\u7d20\u5bf9\u524d\u5217\u817a\u764c\u7ec6\u80de\u5177\u6709\u751f\u957f\u6291\u5236\u4f5c\u7528\u3002\u6cdb\u7d20\u7ed3\u5408\u9176E2C\uff08ubiquitin-conjugating enzyme E2C\uff0cUBE2C\uff09\u662f\u6709\u4e1d\u5206\u88c2\u5468\u671f\u86cb\u767d\u548c\u8c03\u63a7\u540e\u671f\u4fc3\u8fdb\u590d\u5408\u4f53\u6240\u5fc5\u9700\u7684\uff0c\u5e76\u4e14\u5728\u524d\u5217\u817a\u764c\u7ec6\u80de\u4e2d\uff0c\u786e\u5b9aUBE2C\u4e3a\u5fae\u5c0fRNA-381-3p\uff08microRNA-381-3p\uff0cmiR-381-3p\uff09\u7684\u76f4\u63a5\u9776\u57fa\u56e0\u3002\u901a\u8fc7\u5206\u6790UBE2C\u5728\u524d\u5217\u817a\u764c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u53d1\u73b0\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u901a\u8fc7\u4e0a\u8c03\u524d\u5217\u817a\u764c\u7ec6\u80de\u4e2dmicroRNA\u3001miR-381-3p\uff0c\u8fdb\u800c\u4e0b\u8c03\u524d\u5217\u817a\u764c\u7ec4\u7ec7\u4e2dUBE2C\u8868\u8fbe\uff0c\u4f7f\u8f6c\u57fa\u56e0\u524d\u5217\u817a\u764c\u5c0f\u9f20\u80bf\u7624\u7684\u53d1\u5c55\u53d7\u5230\u6291\u5236\uff0c\u4ee5\u8fbe\u5230\u5bf9\u524d\u5217\u817a\u764c\u7684\u6297\u764c\u4f5c\u7528\u3002Wu\u7b49<sup>[26]<\/sup>\u7814\u7a76\u53d1\u73b0\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08human epidermal growth factor receptor 2\uff0cHER2\uff09\u548c\u591a\u7624\u75c5\u6bd2\u589e\u5f3a\u5b50\u6fc0\u6d3b\u56e0\u5b503\uff08polyomavirus enhancer activator 3\uff0cPEA3\uff09\u662f\u53c2\u4e0e\u524d\u5217\u817a\u764c\u53d1\u751f\u53d1\u5c55\u7684\u5173\u952e\u56e0\u5b50\uff0c\u6deb\u7f8a\u85ff\u7d20\u80fd\u901a\u8fc7\u4e0a\u8c03PEA3\u7684\u8868\u8fbe\uff0c\u6291\u5236HER2\u7684\u8f6c\u5f55\u6d3b\u6027\uff0c\u4ece\u800c\u6291\u5236HER2\u4ecb\u5bfc\u7684\u524d\u5217\u817a\u764c\u53d1\u5c55\u30021.4 \u5bf9\u4e73\u817a\u764c\u7684\u4f5c\u7528\u4e73\u817a\u764c\u662f\u76ee\u524d\u6700\u5e38\u89c1\u7684\u764c\u75c7\uff0c\u4e25\u91cd\u5371\u5bb3\u5973\u6027\u7684\u751f\u5b58\u53ca\u5065\u5eb7\uff0c\u662f\u5168\u7403\u5973\u6027\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u901a\u5e38\u9700\u8981\u8fdb\u884c\u836f\u7269\u5316\u7597\u548c\u624b\u672f\u5207\u9664\u6cbb\u7597\uff0c\u4f46\u672f\u540e\u60a3\u8005\u7684\u521b\u4f24\u8f83\u5927\uff0c\u4e14\u5207\u9664\u4e0d\u5f7b\u5e95\u590d\u53d1\u7387\u6781\u9ad8\u3002\u7814\u7a76\u8868\u660e\uff0c\u6deb\u7f8a\u85ff\u7d20\u5bf9\u4e73\u817a\u764c\u5177\u6709\u4e00\u5b9a\u7684\u6291\u5236\u4f5c\u7528\uff0c\u5176\u6297\u4e73\u817a\u764c\u4f5c\u7528\u4e0e\u96cc\u6fc0\u7d20\u53d7\u4f53\u7684\u8c03\u8282\u5bc6\u5207\u76f8\u5173\u3002Tao\u7b49<sup>[27]<\/sup>\u91c7\u7528\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08estrogen receptor\uff0cER\uff09\u9633\u6027\u7684\u4eba\u4e73\u817a\u764cMCF-7\u7ec6\u80de\u548cER\u9634\u6027\u7684\u4eba\u4e73\u817a\u764cMDA-MB-231\u7ec6\u80de\u7814\u7a76\u6deb\u7f8a\u85ff\u7d20\u5bf9\u7ec6\u80de\u7684\u5f71\u54cd\u3002\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u8bf1\u5bfcMCF-7\u7ec6\u80de\u81ea\u566c\uff0c\u6291\u5236MDA-MB-231\u548cMCF-7\u7ec6\u80de\u7684\u589e\u6b96\u548c\u8fc1\u79fb\uff0c\u5e76\u8bf1\u5bfc\u7ec6\u80de\u5468\u671f\u505c\u6ede\u3002\u5176\u4f5c\u7528\u673a\u5236\u4e3a\u6deb\u7f8a\u85ff\u7d20\u901a\u8fc7\u6fc0\u6d3bCaspase-3\uff0c\u589e\u52a0\u5fae\u7ba1\u76f8\u5173\u86cb\u767d\u8f7b\u94fe3II\uff08microtubule-associated-proteinlight-chain<br \/>\n3II\uff0cLC3II\uff09\/LC3I\uff0c\u4fc3\u8fdbp62\u7684\u964d\u89e3\uff0c\u79ef\u7d2f\u5185\u6e90\u6027\u7684LC3\u6591\u70b9\u5f62\u6210\uff0c\u5e76\u589e\u52a0\u81ea\u566c\u901a\u91cf\uff0c\u4ece\u800c\u8bf1\u5bfcMDA-MB-231\u7ec6\u80de\u51cb\u4ea1\uff0c\u5e76\u4fc3\u8fdbMCF-7\u7ec6\u80de\u81ea\u566c\u3002\u6b64\u5916\uff0c\u6709\u7814\u7a76\u53d1\u73b0ER\u03b136\u901a\u8fc7\u6fc0\u6d3bPI3K\/Akt\u4fe1\u53f7\u901a\u8def\u53c2\u4e0e\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08triple-negative breast cancer\uff0cTNBC\uff09\u7ec6\u80de\u7684\u6076\u6027\u589e\u6b96\uff0c\u4e14\u5176\u8868\u8fbe\u6c34\u5e73\u5728TNBC\u7ec6\u80de\u4e2d\u8f83\u9ad8\u3002\u6deb\u7f8a\u85ff\u7d20\u53ef\u4ee5\u4e0b\u8c03ER\u03b136\u8868\u8fbe\uff0c\u6291\u5236TNBC\u7ec6\u80de\u7684\u589e\u6b96\u548c\u8bf1\u5bfc\u5176\u51cb\u4ea1\u3002\u4e14\u6deb\u7f8a\u85ff\u7d20\u548c\u897f\u59a5\u6614\u5355\u6297\u8054\u7528\u8fd8\u53ef\u534f\u540c\u6291\u5236TNBC\u7ec6\u80de\u7684\u589e\u6b96\u5e76\u4fc3\u8fdb\u5176\u51cb\u4ea1<sup>[28]<\/sup>\u3002\u56e0\u6b64\uff0c\u6deb\u7f8a\u85ff\u7d20\u5728\u80bf\u7624\u65b0\u7b56\u7565\u6cbb\u7597\u4e2d\u62e5\u6709\u5de8\u5927\u7684\u6f5c\u529b\u3002\u7efc\u4e0a\uff0c\u6deb\u7f8a\u85ff\u7d20\u4f5c\u4e3a\u4e00\u79cd\u4e2d\u836f\u6d3b\u6027\u6210\u5206\uff0c\u5728\u6297\u80bf\u7624\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u591a\u65b9\u9762\u7684\u6f5c\u529b\uff0c\u5305\u62ec\u901a\u8fc7\u591a\u9776\u70b9\u7b56\u7565\u6291\u5236\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u3001\u8c03\u8282\u514d\u75ab\u7cfb\u7edf\u3001\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94\u53ca\u4e0e\u73b0\u6709\u6cbb\u7597\u65b9\u6cd5\u7684\u534f\u540c\u4f5c\u7528\u3002\u9488\u5bf9\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\u3001\u809d\u764c\u3001\u524d\u5217\u817a\u764c\u548c\u4e73\u817a\u764c\u7b49\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u7814\u7a76\u8868\u660e\uff0c\u6deb\u7f8a\u85ff\u7d20\u5177\u6709\u663e\u8457\u7684\u6297\u80bf\u7624\u6548\u679c\u548c\u8f83\u4f4e\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u663e\u793a\u51fa\u4f5c\u4e3a\u672a\u6765\u6297\u80bf\u7624\u836f\u7269\u7684\u5de8\u5927\u6f5c\u529b\uff08\u56fe1\uff09\u3002\u7136\u800c\uff0c\u4e3a\u4e86\u786e\u4fdd\u5176\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u4ecd\u9700\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u8bd5\u9a8c\u548c\u7814\u7a76\u6765\u4f18\u5316\u6cbb\u7597\u65b9\u6848\uff0c\u5e76\u63a2\u7d22\u5176\u5728\u4e2a\u6027\u5316\u533b\u7597\u4e2d\u7684\u5e94\u7528\u30022 \u6297\u708e\u4f5c\u7528\u708e\u75c7\u662f\u4e00\u4e2a\u590d\u6742\u7684\u75c5\u7406\u751f\u7406\u8fc7\u7a0b\uff0c\u7531\u5bbf\u4e3b\u7684\u5fae\u5faa\u73af\u7cfb\u7edf\u4ecb\u5bfc\uff0c\u4ee5\u62b5\u5fa1\u5316\u5b66\u6210\u5206\u3001\u5fae\u751f\u7269\u75c5\u539f\u4f53\u5f15\u8d77\u7684\u523a\u6fc0\u548c\u611f\u67d3\u7b49\u75c5\u7406\u72b6\u6001\u4e3a\u4e3b\u8981\u8868\u73b0\u3002\u7136\u800c\uff0c\u8fc7\u5ea6\u7684\u708e\u75c7\u53cd\u5e94\u53ef\u80fd\u4f1a\u5bfc\u81f4\u8fdb\u884c\u6027\u7ec4\u7ec7\u635f\u4f24\uff0c\u5e76\u4e14\u8fd8\u4f1a\u5728\u764c\u75c7\u7b49\u8bb8\u591a\u6162\u6027\u75be\u75c5\u7684\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u4e0d\u65ad\u6f14\u53d8<sup>[29]<\/sup>\u3002\u76ee\u524d\u708e\u75c7\u6027\u75be\u75c5\u7684\u6cbb\u7597\u8f83\u4e3a\u5355\u4e00\uff0c\u4e3b\u8981\u4ee5\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\u7269\u6cbb\u7597\u4e3a\u4e3b\uff0c\u4f46\u957f\u671f\u4f7f\u7528\u6b64\u7c7b\u836f\u7269\u4f1a\u5f15\u53d1\u591a\u79cd\u4e0d\u826f\u53cd\u5e94<sup>[30]<\/sup>\uff0c\u8fd9\u4e9b\u4e0d\u826f\u53cd\u5e94\u7ed9\u60a3\u8005\u9020\u6210\u4e86\u989d\u5916\u8d1f\u62c5\u3002\u56e0\u6b64\uff0c\u5bfb\u627e\u9009\u62e9\u6027\u9ad8\u3001\u4e0d\u826f\u53cd\u5e94\u5c0f\u7684\u65b0\u578b\u6297\u708e\u836f\u7269\u8feb\u5728\u7709\u776b\u3002\u8fd1\u5e74\u6765\uff0c\u6deb\u7f8a\u85ff\u7d20\u4f5c\u4e3a\u4e00\u79cd\u5929\u7136\u7684\u690d\u7269\u96cc\u6fc0\u7d20\uff0c\u5176\u5728\u6297\u708e\u65b9\u9762\u5177\u6709\u7684\u79ef\u6781\u4f5c\u7528\u5907\u53d7\u5173\u6ce8\u30022.1 \u5bf9\u76ae\u80a4\u708e\u75c7\u7684\u6297\u708e\u4f5c\u7528\u7d2b\u5916\u7ebf\u8f90\u5c04\u662f\u8bf1\u5bfc\u5404\u7c7b\u76ae\u80a4\u75c5\u53d1\u751f\u548c\u53d1\u5c55\u7684\u5173\u952e\u5371\u9669\u56e0\u7d20<sup>[31]<\/sup>\u3002\u7814\u7a76\u53d1\u73b0\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684\u76ae\u80a4\u8001\u5316\u7684\u4e3b\u8981\u539f\u56e0\u662f\u7d2b\u5916\u7ebfB\uff08ultraviolet B\uff0cUVB\uff09\u8bf1\u5bfc\u7ec6\u80de\u5185\u5f62\u6210\u8fc7\u91cf\u6d3b\u6027\u6c27\uff0c\u7834\u574f\u4e86\u7ec6\u80de\u7684\u6c27\u5e73\u8861\u5e76\u5bfc\u81f4\u6c27\u5316\u5e94\u6fc0<sup>[32]<\/sup>\u3002Hwang\u7b49<sup>[33]<\/sup>\u5728\u7814\u7a76\u6deb\u7f8a\u85ff\u7d20\u548c\u6deb\u7f8a\u85ff\u82f7\u5bf9UVB\u7167\u5c04\u8bf1\u53d1\u7684\u4eba\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u7684\u6297\u708e\u4f5c\u7528\u4e2d\uff0c\u53d1\u73b0\u6deb\u7f8a\u85ff\u7d20\u548c\u6deb\u7f8a\u85ff\u82f7\u5bf9\u81ea\u7531\u57fa\u5177\u6709\u8f83\u5f3a\u7684\u6e05\u9664\u4f5c\u7528\uff0c\u5176\u4e2d\u6deb\u7f8a\u85ff\u7d20\u6e05\u9664\u6d3b\u6027\u6c27\u7684\u80fd\u529b\u66f4\u5f3a\uff0c\u5e76\u4e14\u53ef\u901a\u8fc7\u6291\u5236\u76ae\u80a4\u708e\u75c7\u548c\u8bf1\u5bfc\u80f6\u539f\u86cb\u767d\u7684\u751f\u7269\u5408\u6210\u9632\u6b62UVB\u8bf1\u5bfc\u7684\u76ae\u80a4\u8001\u5316\uff0c\u5176\u4f5c\u7528\u673a\u5236\u4e3a\u6deb\u7f8a\u85ff\u7d20\u6fc0\u6d3b\u6838\u56e0\u5b50E2\u76f8\u5173\u56e0\u5b502\uff08nuclear factor E2 related factor<br \/>\n2\uff0cNrf2\uff09\uff0c\u63d0\u9ad8\u4e86\u6297\u6c27\u5316\u5e94\u6fc0\u80fd\u529b\uff0c\u5e76\u4e14\u6291\u5236\u6838\u56e0\u5b50-\u03baB\uff08nuclear factor-\u03baB\uff0cNF-\u03baB\uff09\u7684\u6fc0\u6d3b\uff0c\u51cf\u5c11\u4e86\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u86cb\u767d\u548c\u708e\u75c7\u56e0\u5b50\u8bf1\u5bfc\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u964d\u89e3\u9176\u5206\u6ccc\u3002\u6b64\u5916\uff0c\u6deb\u7f8a\u85ff\u7d20\u6bd4\u6deb\u7f8a\u85ff\u82f7\u66f4\u6709\u5229\u4e8e\u63d0\u9ad8\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b21\uff08transforming growth factor-\u03b21\uff0cTGF-\u03b21\uff09\u548cI\u578b\u524d\u80f6\u539f\u7684\u8868\u8fbe\uff0c\u4fc3\u8fdb\u80f6\u539f\u86cb\u767d\u7684\u5408\u6210\u3002\u591a\u897f\u7d2b\u6749\u9187\u5728\u6cbb\u7597\u80bf\u7624\u7684\u8fc7\u7a0b\u4e2d\uff0c\u53ef\u51cf\u5c11\u7ec6\u80de\u5185\u7ebf\u7c92\u4f53\u6570\u91cf\uff0c\u589e\u52a0\u6d3b\u6027\u6c27\u7684\u7d2f\u79ef\uff0c\u9020\u6210\u7ec6\u80de\u6d3b\u529b\u5e76\u5bfc\u81f4\u76ae\u80a4\u635f\u4f24\u3002\u800c\u6deb\u7f8a\u85ff\u7d20\u4f5c\u4e3aER\u8c03\u8282\u5242\uff0c\u53ef\u901a\u8fc7ER\u9014\u5f84\u6fc0\u6d3b\u817a\u82f7\u9178\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08adenosine phosphate activated protein<br \/>\nkinase\uff0cAMPK\uff09\u6765\u8c03\u8282\u81ea\u566c\u548c\u6d3b\u6027\u6c27\u6c34\u5e73\uff0c\u4ece\u800c\u51cf\u8f7b\u591a\u897f\u7d2b\u6749\u9187\u8bf1\u5bfc\u7684\u76ae\u80a4\u635f\u4f24<sup>[34]<\/sup>\u3002\u6b64\u5916\uff0c\u6deb\u7f8a\u85ff\u7d20\u548c\u591a\u897f\u7d2b\u6749\u9187\u8054\u7528\u4e5f\u4e3a\u540e\u7eed\u4e34\u5e8a\u6cbb\u7597\u80bf\u7624\u65f6\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94\u63d0\u4f9b\u4e86\u65b0\u7684\u7b56\u7565\u3002\u764c\u75c7\u662f\u4e16\u754c\u53d1\u75c5\u7387\u548c\u81f4\u6b7b\u7387\u6700\u9ad8\u7684\u75be\u75c5\u4e4b\u4e00\uff0c\u5728\u764c\u75c7\u7684\u6cbb\u7597\u624b\u6bb5\u4e2d\uff0c\u653e\u5c04\u6cbb\u7597\u5360\u636e\u91cd\u8981\u5730\u4f4d\u3002\u867d\u7136\u968f\u7740\u653e\u5c04\u6cbb\u7597\u6280\u672f\u7684\u4e0d\u65ad\u8fdb\u6b65\u4f18\u5316\uff0c\u4e0e\u8fc7\u53bb\u653e\u5c04\u6cbb\u7597\u6280\u672f\u76f8\u6bd4\u8f83\uff0c\u964d\u4f4e\u4e86\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u7684\u635f\u4f24\uff0c\u4f46\u653e\u5c04\u6cbb\u7597\u5728\u6740\u4f24\u3001\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u540c\u65f6\uff0c\u5bf9\u653e\u5c04\u5468\u56f4\u6b63\u5e38\u7ec4\u7ec7\u7684\u635f\u4f24\u4ecd\u4e0d\u5bb9\u5ffd\u89c6<sup>[35]<\/sup>\u3002\u8fd1\u5e74\u6765\uff0c\u5728\u51cf\u5c11\u653e\u7597\u4e0d\u826f\u53cd\u5e94\u65b9\u9762\u7684\u7814\u7a76\u53d6\u5f97\u4e86\u65b0\u7684\u7a81\u7834\u3002\u7814\u7a76\u53d1\u73b0\u6deb\u7f8a\u85ff\u7d20\u80fd\u591f\u7f13\u89e3\u5c0f\u9f20\u6025\u6027\u653e\u5c04\u6027\u76ae\u708e\u7684\u75c7\u72b6\uff0c\u5e76\u5bf9\u8f6f\u7ec4\u7ec7\u653e\u5c04\u6027\u7ea4\u7ef4\u5316\u6709\u4e00\u5b9a\u7684\u6539\u5584\u4f5c\u7528\u3002\u7ec6\u80de\u5b9e\u9a8c\u8868\u660e\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u4ee5\u51cf\u5c11\u6d3b\u6027\u6c27\u7684\u4ea7\u751f\uff0c\u5e76\u6291\u5236\u708e\u75c7\u56e0\u5b50IL-1\u03b2\u3001IL-6\u3001\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\uff08tumor necrosis factor-\u03b1\uff0cTNF-\u03b1\uff09\u7684\u5206\u6ccc<sup>[36]<\/sup>\u3002\u8868\u660e\u6deb\u7f8a\u85ff\u7d20\u80fd\u591f\u51cf\u8f7b\u5916\u754c\u56e0\u7d20\u5f15\u8d77\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u5e76\u5bf9\u76ae\u80a4\u635f\u4f24\u5177\u6709\u4e00\u5b9a\u7684\u4fdd\u62a4\u4f5c\u7528\u3002\u7136\u800c\uff0c\u76ee\u524d\u5176\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u660e\u786e\uff0c\u4ecd\u9700\u8fdb\u4e00\u6b65\u6df1\u5165\u7814\u7a76\uff0c\u4ee5\u63ed\u793a\u6deb\u7f8a\u85ff\u7d20\u5728\u653e\u7597\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u548c\u6f5c\u5728\u5e94\u7528\u30022.2 \u5bf9\u80ba\u90e8\u635f\u4f24\u7684\u4fdd\u62a4\u4f5c\u7528\u6025\u6027\u80ba\u635f\u4f24\uff08acute lung<br \/>\ninjury\uff0cALI\uff09\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u4e34\u5e8a\u5371\u91cd\u75be\u75c5\uff0c\u8fc7\u5ea6\u7684\u708e\u75c7\u53cd\u5e94\u4e0e\u80ba\u5fae\u8840\u7ba1\u5c4f\u969c\u7684\u7834\u574f\u662fALI\u53d1\u75c5\u673a\u5236\u7684\u5173\u952e\u673a\u5236\uff0c\u5e76\u4e14\u6709\u7814\u7a76\u8868\u660e\uff0c\u708e\u75c7\u53cd\u5e94\u5728ALI\u7684\u53d1\u751f\u8fc7\u7a0b\u4e2d\u5177\u6709\u5173\u952e\u4f5c\u7528<sup>[37]<\/sup>\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u7ecf\u8102\u591a\u7cd6\u5904\u7406\u540e\u7684\u5c0f\u9f20\uff0c\u5176\u80ba\u6ce1\u704c\u6d17\u6db2\u4e2d\u767d\u7ec6\u80de\u603b\u6570\u663e\u8457\u589e\u52a0\uff0c\u800c\u7ecf\u6deb\u7f8a\u85ff\u7d20\u5904\u7406\u540e\u7684\u5c0f\u9f20\u80ba\u6ce1\u704c\u6d17\u6db2\u4e2d\u7684\u767d\u7ec6\u80de\u603b\u6570\u663e\u8457\u964d\u4f4e\uff0c\u7ed3\u679c\u4e0e\u9633\u6027\u836f\u4e00\u81f4\u3002\u5b9e\u9a8c\u8868\u660e\u6deb\u7f8a\u85ff\u7d20\u53ef\u6291\u5236\u708e\u75c7\u56e0\u5b50IL-1\u03b2\u3001IL-6\u3001TNF-\u03b1\u7684\u5206\u6ccc\uff0c\u5bf9\u80ba\u90e8\u611f\u67d3\u5bfc\u81f4\u7684\u708e\u75c7\u6709\u6291\u5236\u4f5c\u7528\uff0c\u4ece\u800c\u53ef\u4ee5\u51cf\u8f7b\u708e\u75c7\u4ecb\u5bfc\u7684\u80ba\u90e8\u635f\u4f24<sup>[38]<\/sup>\u3002\u80ba\u8f6c\u79fb\u4e00\u76f4\u4ee5\u6765\u90fd\u662f\u591a\u79cd\u6076\u6027\u80bf\u7624\u5e38\u89c1\u7684\u5668\u5b98\u8f6c\u79fb\uff0c\u540c\u6837\u4e5f\u662f\u80bf\u7624\u60a3\u8005\u9884\u540e\u9762\u4e34\u7684\u4e3b\u8981\u95ee\u9898\u3002\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u5916\u6ccc\u4f53\u5728\u80bf\u7624\u8f6c\u79fb\u4e2d\u6709\u7740\u91cd\u8981\u7684\u4f5c\u7528<sup>[39]<\/sup>\uff0c\u5176\u4fc3\u80bf\u7624\u8f6c\u79fb\u7684\u673a\u5236\u53ef\u80fd\u4e0e\u708e\u75c7\u56e0\u5b50\u7684\u6d78\u6da6\u5bc6\u5207\u76f8\u5173\u3002\u5c60\u4e66\u6885\u7b49<sup>[40]<\/sup>\u7814\u7a76\u53d1\u73b0\u6deb\u7f8a\u85ff\u7d20\u80fd\u663e\u8457\u6291\u5236\u80ba\u7ec4\u7ec7\u4e2d\u4fc3\u708e\u56e0\u5b50S100\u9499\u7ed3\u5408\u86cb\u767dA8\/A9\u590d\u5408\u7269\u3001\u8840\u6e05\u6dc0\u7c89\u6837\u86cb\u767dA\u548cIL-6\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u6291\u5236\u5916\u6ccc\u4f53\u8bf1\u5bfc\u7684\u9ed1\u8272\u7d20\u7624\u5411\u80ba\u90e8\u8f6c\u79fb\uff0c\u51cf\u5c11\u5bf9\u80ba\u7ec4\u7ec7\u7684\u635f\u4f24\u30022.3 &nbsp;\u5bf9\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\uff08nonalcoholic fatty liver disease\uff0cNAFLD\uff09\u7684\u4fdd\u62a4\u4f5c\u7528NAFLD\u662f\u4ee5\u809d\u7ec6\u80de\u5185\u8102\u80aa\u5806\u79ef\u548c\u6c89\u79ef\u8fc7\u591a\u4e3a\u4e3b\u8981\u7279\u5f81\u7684\u809d\u810f\u53d8\u6027\u75be\u75c5<sup>[41]<\/sup>\u3002\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0c\u8eab\u4f53\u5b58\u5728\u4e00\u4e9b\u4ee3\u8c22\u75be\u75c5\u6216\u8eab\u5904\u4e25\u5bd2\u73af\u5883\u65f6\uff0c\u4f53\u5185\u7684\u8102\u80aa\u7ec4\u7ec7\u5bb9\u6613\u53d7\u5230\u635f\u4f24\uff0c\u8fdb\u800c\u53d1\u751f\u6162\u6027\u708e\u75c7\uff0cIL-1\u03b2\u3001IL-6\u3001TNF-\u03b1\u7b49\u708e\u75c7\u56e0\u5b50\u5206\u6ccc\u589e\u52a0\u5e76\u901a\u8fc7\u4f53\u5faa\u73af\u4f5c\u7528\u4e8e\u809d\u810f\uff0c\u4fc3\u8fdb\u809d\u810f\u7684\u708e\u6027<sup>[42]<\/sup>\u3002Wu\u7b49<sup>[43]<\/sup>\u901a\u8fc7\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\uff0c\u5c06\u6deb\u7f8a\u85ff\u7d20\u4f5c\u7528\u4e8eL02\u3001Huh-7\u7ec6\u80de24 h\uff0c\u7ed3\u679c\u8868\u660e\u6deb\u7f8a\u85ff\u7d20\u53ef\u660e\u663e\u6291\u5236L02\u3001Huh-7\u7ec6\u80de\u7684\u8102\u8d28\u84c4\u79ef\uff0c\u4fc3\u8fdbL02\u7ec6\u80de\u7ebf\u7c92\u4f53\u7684\u751f\u7269\u5408\u6210\u3002\u6deb\u7f8a\u85ff\u7d20\u901a\u8fc7\u4fc3\u8fdb\u5c0f\u9f20\u80da\u80ce\u6210\u7ea4\u7ef43T3-L1\u7ec6\u80de\u548c\u5c0f\u9f20\u6210\u808cC2C12\u7ec6\u80de\u5bf9\u8461\u8404\u7cd6\u7684\u6444\u53d6\uff0c\u964d\u4f4e\u4e09\u78f7\u9178\u817a\u82f7\u542b\u91cf\uff0c\u6fc0\u6d3bAMPK\u4fe1\u53f7\u901a\u8def\u3002\u6b64\u5916\uff0c\u8fd8\u53ef\u4ee5\u4fc3\u8fdb3T3-L1\u3001C2C12\u7ec6\u80de\u7684\u81ea\u566c\uff0c\u51cf\u5c113T3-L1\u3001C2C12\u7ec6\u80de\u7684\u81ea\u566c\uff0c\u4ece\u800c\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u7684\u751f\u7269\u53d1\u751f\u3002\u56e0\u6b64\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u4ee5\u901a\u8fc7\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u548c\u901a\u8fc7\u6fc0\u6d3bAMPK\u9014\u5f84\u8c03\u8282\u81ea\u566c\u6765\u51cf\u5c11\u8102\u80aa\u5806\u79ef\uff0c\u964d\u4f4e\u8102\u80aa\u7ec6\u80de\u7684\u6162\u6027\u708e\u75c7\u53cd\u5e94\uff0c\u8fbe\u5230\u5bf9NAFLD\u7684\u4fdd\u62a4\u4f5c\u7528\u30022.4 &nbsp;\u5bf9\u795e\u7ecf\u708e\u75c7\u7684\u6297\u708e\u4f5c\u7528\u6291\u90c1\u75c7\u662f\u4e00\u79cd\u60a3\u75c5\u7387\u9ad8\u7684\u60c5\u611f\u963b\u788d\u6027\u75be\u75c5\uff0c\u4e0e\u514d\u75ab\u5931\u8c03\u548c\u708e\u75c7\u5bc6\u5207\u76f8\u5173\u3002\u7531\u4e8e\u60a3\u8005\u5bf9\u8be5\u75c5\u7f3a\u4e4f\u8db3\u591f\u8ba4\u77e5\uff0c\u5bfc\u81f4\u60a3\u8005\u5bf9\u6291\u90c1\u75c7\u7f3a\u4e4f\u8db3\u591f\u91cd\u89c6\uff0c\u56e0\u6b64\u8be5\u75c5\u6cbb\u7597\u7387\u4f4e\uff0c\u4e14\u590d\u53d1\u7387\u9ad8<sup>[44]<\/sup>\u3002\u7ec6\u80de\u56e0\u5b50\u5f15\u8d77\u7684\u4e0b\u4e18\u8111-\u5782\u4f53-\u80be\u4e0a\u817a\u8f74\u5f02\u662f\u6291\u90c1\u75c7\u7684\u5173\u952e\u795e\u7ecf\u751f\u7269\u5b66\u56e0\u7d20\uff0c\u800c\u795e\u7ecf\u708e\u75c7\u5728\u6291\u90c1\u75c7\u7684\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002Liu\u7b49<sup>[45]<\/sup>\u7814\u7a76\u53d1\u73b0\u6deb\u7f8a\u85ff\u7d20\u53ef\u663e\u8457\u6539\u5584\u5c0f\u9f20\u7684\u6291\u90c1\u884c\u4e3a\uff0c\u5176\u4f5c\u7528\u673a\u5236\u4e0e\u6291\u5236\u9ad8\u8fc1\u79fb\u7387\u65cf\u86cb\u767d\u76d21\/\u665a\u671f\u7cd6\u57fa\u5316\u7ec8\u4ea7\u7269\u53d7\u4f53\u4fe1\u53f7\u8f6c\u5bfc\u5e76\u540c\u65f6\u6fc0\u6d3bToll\u6837\u53d7\u4f534\uff08Toll-like receptor 4\uff0cTLR4\uff09NF-\u03baB\u4fe1\u53f7\u4f20\u5bfc\u6709\u5173\uff0c\u6539\u5584\u6d77\u9a6c\u7684\u795e\u7ecf\u708e\u75c7\uff0c\u5bf9\u795e\u7ecf\u8d77\u4fdd\u62a4\u4f5c\u7528\u3002\u636e\u62a5\u9053\uff0c\u6709\u6548\u6291\u5236\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684\u708e\u75c7\u53cd\u5e94\u53ef\u4ee5\u5bf9\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684\u708e\u75c7\u75c5\u53d8\u7b49\u75be\u75c5\u8d77\u5173\u952e\u4f5c\u7528<sup>[46]<\/sup>\u3002\u5f20\u6587\u5a23\u7b49<sup>[47]<\/sup>\u5728\u7814\u7a76\u6deb\u7f8a\u85ff\u7d20\u5bf9\u8102\u591a\u7cd6\u8bf1\u5bfc\u7684\u539f\u4ee3\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u708e\u75c7\u53cd\u5e94\u7684\u6291\u5236\u4f5c\u7528\u4e2d\uff0c\u53d1\u73b0\u6deb\u7f8a\u85ff\u7d20\u80fd\u591f\u901a\u8fc7\u6fc0\u6d3bER\u9014\u5f84\u6765\u6291\u5236\u8102\u591a\u7cd6\u8bf1\u5bfc\u7684\u539f\u4ee3\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u73af\u6c27\u5408\u9176-2\uff08cyclooxygenase-2\uff0cCOX-2\uff09\u548c\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176\uff08inducible nitric oxide synthase\uff0ciNOS\uff09\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u53d1\u6325\u6297\u795e\u7ecf\u708e\u75c7\u4f5c\u7528\u30022.5 \u5bf9\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u7684\u4fdd\u62a4\u4f5c\u7528\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u662f\u4e00\u79cd\u590d\u53d1\u7387\u9ad8\u7684\u4e0d\u6cbb\u4e4b\u75c7\u3002\u5c3d\u7ba1\u6297\u8840\u5c0f\u677f\u836f\u7269\u548c\u4ed6\u6c40\u7c7b\u836f\u7269\u5728\u4e00\u7ea7\u548c\u4e8c\u7ea7\u5352\u4e2d\u9884\u9632\u4e2d\u7684\u5e94\u7528\u5e7f\u6cdb\uff0c\u4f46\u4ecd\u9700\u8981\u65b0\u7684\u6709\u6548\u7b56\u7565<sup>[48]<\/sup>\u3002\u5929\u7136\u836f\u7269\u662f\u73b0\u4ee3\u533b\u5b66\u53d1\u5c55\u7684\u91cd\u8981\u6e90\u6cc9\u3002N-\u7532\u57fa-D-\u5929\u51ac\u6c28\u9178\u53d7\u4f53\u662f\u8111\u7f3a\u8840\u65f6\u4ecb\u5bfc\u5174\u594b\u6027\u6bd2\u6027\u7684\u5173\u952e\u4fe1\u53f7\u5206\u5b50\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u6291\u5236\u5174\u594b\u6027\u6bd2\u6027\u635f\u4f24\uff0c\u5bf9\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u5176\u673a\u5236\u53ef\u80fd\u4e0e\u589e\u5f3a\u7ec6\u80de\u5916\u8c03\u8282\u86cb\u767d\u6fc0\u9176\uff08extracellular regulated protein<br \/>\nkinases\uff0cERK\uff09\u4fe1\u53f7\u901a\u8def\u6fc0\u6d3b\u3001\u8c03\u8282\u7a81\u89e6\u5185\u5916N-\u7532\u57fa-D-\u5929\u51ac\u6c28\u9178\u53d7\u4f53\u529f\u80fd\u6709\u5173<sup>[49]<\/sup>\u3002\u6b64\u5916\uff0cYu\u7b49<sup>[50]<\/sup>\u7814\u7a76\u53d1\u73b0\u6deb\u7f8a\u85ff\u7d20\u53ef\u80fd\u901a\u8fc7G\u86cb\u767d\u5076\u8054\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08G protein-coupled estrogen<br \/>\nreceptor\uff0cGPER\uff09\/ERK\/ NF-\u03baB\u4fe1\u53f7\u901a\u8def\u8c03\u8282\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u6781\u5316\uff0c\u4ece\u800c\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u51cf\u8f7b\u5927\u9f20\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u540e\u7684\u795e\u7ecf\u708e\u75c7\u53cd\u5e94\uff0c\u4e3a\u9632\u6cbb\u8111\u7f3a\u8840\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9014\u5f84\u3002\u6deb\u7f8a\u85ff\u7d20\u4f5c\u4e3a\u4e00\u79cd\u5177\u6709\u5e7f\u6cdb\u6297\u708e\u4f5c\u7528\u7684\u5929\u7136\u690d\u7269\u96cc\u6fc0\u7d20\uff0c\u5176\u5728\u76ae\u80a4\u3001\u80ba\u90e8\u3001\u809d\u810f\u3001\u795e\u7ecf\u7cfb\u7edf\u548c\u8111\u90e8\u7b49\u591a\u4e2a\u7ec4\u7ec7\u548c\u5668\u5b98\u4e2d\u5c55\u73b0\u51fa\u663e\u8457\u7684\u4fdd\u62a4\u4f5c\u7528\u3002\u901a\u8fc7\u8c03\u8282\u591a\u79cd\u4fe1\u53f7\u901a\u8def\uff0c\u5982NF-\u03baB\u3001Nrf2\u3001AMPK\u3001ERK\u7b49\uff0c\u6deb\u7f8a\u85ff\u7d20\u4e0d\u4ec5\u80fd\u591f\u6709\u6548\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u8fd8\u80fd\u4fc3\u8fdb\u7ec4\u7ec7\u4fee\u590d\u548c\u518d\u751f\uff0c\u51cf\u5c11\u764c\u75c7\u6cbb\u7597\u548c\u653e\u5c04\u6cbb\u7597\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u56fe2\uff09\u3002\u8fd9\u4e9b\u7279\u6027\u4f7f\u5f97\u6deb\u7f8a\u85ff\u7d20\u6210\u4e3a\u5f00\u53d1\u65b0\u578b\u6297\u708e\u836f\u7269\u7684\u6f5c\u5728\u5019\u9009\uff0c\u5c24\u5176\u662f\u5728\u6cbb\u7597\u708e\u75c7\u76f8\u5173\u75be\u75c5\u65b9\u9762\u5177\u6709\u91cd\u8981\u4ef7\u503c\u3002\u7136\u800c\uff0c\u5c3d\u7ba1\u6deb\u7f8a\u85ff\u7d20\u7684\u6297\u708e\u6548\u679c\u548c\u4fdd\u62a4\u4f5c\u7528\u5df2\u5f97\u5230\u521d\u6b65\u8bc1\u5b9e\uff0c\u5176\u5177\u4f53\u4f5c\u7528\u673a\u5236\u548c\u4e34\u5e8a\u5e94\u7528\u4ecd\u9700\u8fdb\u4e00\u6b65\u6df1\u5165\u7814\u7a76\u548c\u9a8c\u8bc1\uff0c\u4ee5\u786e\u4fdd\u5176\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u30023 \u514d\u75ab\u8c03\u8282\u4f5c\u7528\u514d\u75ab\u8c03\u8282\u5728\u7ef4\u6301\u4eba\u4f53\u5185\u73af\u5883\u5e73\u8861\u65b9\u9762\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u548c\u9776\u70b9\uff0c\u8c03\u8282\u708e\u6027\u56e0\u5b50\u7684\u4ea7\u751f\u5e76\u5e72\u6270\u514d\u75ab\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u4e14\u4e34\u5e8a\u6bd2\u6027\u4f4e\u3002Lu\u7b49<sup>[51]<\/sup>\u7814\u7a76\u53d1\u73b0\u6deb\u7f8a\u85ff\u7d20\u53ef\u4ee5\u4e0e\u9ad3\u6837\u5206\u5316\u56e0\u5b5088\uff08myeloid differentiation factor 88\uff0cMyD88\uff09\/I\u043aB\u6fc0\u9176\u03b1\u86cb\u767d\u590d\u5408\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u901a\u8fc7\u6291\u5236\u4e0b\u6e38IL-6\/JAK\/STAT3\u4fe1\u53f7\u901a\u8def\uff0c\u4e0b\u8c03\u80bf\u7624\u76f8\u5173\u813e\u810f\u5916\u9ad3\u9020\u8840\uff0c\u4ece\u800c\u51cf\u5c11\u9ad3\u7cfb\u6291\u5236\u7ec6\u80de\u7684\u751f\u6210\u3001\u6d3b\u5316\u548c\u805a\u96c6\uff0c\u6062\u590d\u6548\u5e94T\u7ec6\u80de\u7684\u529f\u80fd\u3002\u652f\u6c14\u7ba1\u54ee\u5598\u662f\u4e00\u79cd\u5148\u5929\u6027\u548c\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\u5bfc\u81f4\u7684\u6301\u7eed\u6027\u547c\u5438\u9053\u708e\u75c7\uff0c\u5e38\u4f34\u6709\u8f85\u52a9\u6027T\u7ec6\u80de1\uff08T helper cell 1\uff0cTh1\uff09\/Th2\u5931\u8861\uff0c\u8868\u73b0\u4e3aTh1\u578b\u7ec6\u80de\u56e0\u5b50\u5982\u03b3\u5e72\u6270\u7d20\u51cf\u5c11\uff0cTh2\u578b\u7ec6\u80de\u56e0\u5b50\u5982IL-4\u3001IL-5\u3001IL-6\u548cIL-13\u5347\u9ad8\u3002\u7814\u7a76\u8868\u660e\u6deb\u7f8a\u85ff\u7d20\u53ef\u4e0b\u8c03\u5375\u6e05\u86cb\u767d\u514d\u75ab\u7403\u86cb\u767d\u3001IL-1\u03b2\u3001IL-4\u3001IL-5\u3001IL-6\u3001IL-13\u548cTNF-\u03b1\u7684\u6c34\u5e73\uff0c\u589e\u52a0\u03b3\u5e72\u6270\u7d20\u7684\u8868\u8fbe\u3002\u56e0\u6b64\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u901a\u8fc7\u8c03\u8282Th1\/Th2\u6765\u6e90\u7684\u7ec6\u80de\u56e0\u5b50\u5e73\u8861\u548c\u5404\u79cd\u514d\u75ab\u76f8\u5173\u4fc3\u708e\u56e0\u5b50\u7684\u5206\u6ccc\uff0c\u6539\u5584\u54ee\u5598\u5f15\u8d77\u7684\u52a8\u7269\u6a21\u578b\u547c\u5438\u9053\u708e\u75c7<sup>[3]<\/sup>\u3002\u5e76\u4e14ERK\/IL-6\/STAT3\u4fe1\u53f7\u901a\u8def\u5728\u8c03\u8282\u764c\u75c7\u708e\u75c7\u548c\u514d\u75ab\u65b9\u9762\u8d77\u591a\u91cd\u8c03\u8282\u4f5c\u7528\uff0c\u6deb\u7f8a\u85ff\u7d20\u53ef\u901a\u8fc7\u6b64\u901a\u8def\u5728\u80bf\u7624\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de\u4e2d\u663e\u793a\u51fa\u6297\u764c\u6d3b\u6027<sup>[52]<\/sup>\u3002\u6deb\u7f8a\u85ff\u7d20\u901a\u8fc7\u5176\u72ec\u7279\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff0c\u663e\u793a\u51fa\u5728\u6cbb\u7597\u591a\u79cd\u514d\u75ab\u76f8\u5173\u75be\u75c5\u4e2d\u7684\u6f5c\u529b\u3002\u901a\u8fc7\u8c03\u8282MyD88\/I\u043aB\u6fc0\u9176\u03b1\u86cb\u767d\u590d\u5408\u7269\u548c\u4e0b\u6e38\u7684IL-6\/ JAK\/STAT3\u4fe1\u53f7\u901a\u8def\uff0c\u6deb\u7f8a\u85ff\u7d20\u80fd\u591f\u6709\u6548\u6291\u5236\u708e\u75c7\u56e0\u5b50\u7684\u4ea7\u751f\uff0c\u51cf\u5c11\u9ad3\u7cfb\u6291\u5236\u7ec6\u80de\u7684\u751f\u6210\uff0c\u4ece\u800c\u6062\u590d\u6548\u5e94T\u7ec6\u80de\u7684\u529f\u80fd\u3002\u6b64\u5916\uff0c\u6deb\u7f8a\u85ff\u7d20\u8fd8\u80fd\u8c03\u8282Th1\/ Th2\u7ec6\u80de\u56e0\u5b50\u7684\u5e73\u8861\uff0c\u6539\u5584\u54ee\u5598\u7b49\u547c\u5438\u9053\u708e\u75c7\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u6deb\u7f8a\u85ff\u7d20\u4e0d\u4ec5\u80fd\u591f\u4f5c\u4e3a\u6297\u708e\u836f\u7269\uff0c\u8fd8\u53ef\u80fd\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u53d1\u6325\u4f5c\u7528\uff0c\u901a\u8fc7\u8c03\u8282ERK\/IL-6\/ 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