{"id":44591,"date":"2024-12-05T05:10:58","date_gmt":"2024-12-05T05:10:58","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=44591"},"modified":"2024-12-05T05:10:58","modified_gmt":"2024-12-05T05:10:58","slug":"%e7%ac%ac%e4%ba%8c%e8%8a%82-%e6%8a%97%e7%99%ab%e7%97%ab%e8%8d%af","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=44591","title":{"rendered":"\u7b2c\u4e8c\u8282 \u6297\u766b\u75eb\u836f"},"content":{"rendered":"

 1. \u766b\u75eb\u75c5    \u766b\u75eb\u662f\u7531\u4e8e\u5927\u8111\u5c40\u90e8\u75c5\u7076\u795e\u7ecf\u5143\u5174\u594b\u6027\u8fc7\u9ad8\uff0c\u4ea7\u751f\u9635\u53d1\u6027\u653e\u7535\uff0c\u5e76\u5411\u5468\u56f4\u6269\u6563\u800c\u51fa\u73b0\u7684\u5927\u8111\u529f\u80fd\u6027\u5931\u8c03\u7efc\u5408\u5f81\u3002\u766b\u75eb\u7684\u4ea7\u751f\u4e0e\u795e\u7ecf\u5143\u5f02\u5e38\u653e\u7535\u76f8\u5173\u3002\u4eba\u4f53\u4f11\u606f\u65f6\uff0c\u4e00\u4e2a\u5927\u8111\u76ae\u8d28\u9525\u4f53\u7ec6\u80de\u7684\u653e\u7535\u9891\u7387\u4e00\u822c\u4fdd\u6301\u57281\uff5e10\u6b21\uff0f\u79d2\u4e4b\u95f4\uff0c\u800c\u5728\u766b\u75eb\u75c5\u7076\u4e2d\uff0c\u4e00\u7ec4\u75c5\u6001\u795e\u7ecf\u5143\u7684\u653e\u7535\u9891\u7387\u53ef\u9ad8\u8fbe\u6bcf\u79d2\u6570\u767e\u6b21\u3002\u75eb\u7076\u7ec6\u80de\u7fa4\u9ad8\u9891\u91cd\u590d\u653e\u7535\uff0c\u4f7f\u5176\u8f74\u7a81\u6240\u76f4\u63a5\u8054\u7cfb\u7684\u795e\u7ecf\u5143\u4ea7\u751f\u8f83\u5927\u7684\u7a81\u89e6\u540e\u7535\u4f4d\uff0c\u4ece\u800c\u4ea7\u751f\u8fde\u7eed\u4f20\u64ad\uff0c\u76f4\u81f3\u6291\u5236\u4f5c\u7528\u4f7f\u53d1\u4f5c\u7ec8\u6b62\u3002\u7531\u4e8e\u4f20\u64ad\u9014\u5f84\u53ca\u8303\u56f4\u4e0d\u540c\u800c\u5f15\u8d77\u5404\u79cd\u5f62\u5f0f\u53d1\u4f5c\u3002\u75eb\u6027\u6d3b\u52a8\u53ef\u80fd\u4ec5\u7275\u6d89\u4e00\u4e2a\u533a\u57df\u7684\u5927\u8111\u76ae\u8d28\u800c\u4e0d\u518d\u6269\u6563\uff0c\u5f15\u8d77\u5355\u7eaf\u90e8\u5206\u6027\u53d1\u4f5c\uff1b\u5174\u594b\u5728\u524d\u4e2d\u592e\u56de\u6216\u540e\u4e2d\u592e\u56de\u901a\u8fc7\u653e\u7535\u540e\u7ec6\u80de\u5916\u94be\u79bb\u5b50\u7684\u589e\u591a\u800c\u4f20\u5bfc\u5230\u90bb\u8fd1\u795e\u7ecf\u5143\uff0c\u9020\u6210\u6770\u514b\u900a(Jackson)\u766b\u75eb\uff1b\u75eb\u6027\u6d3b\u52a8\u5e38\u7531\u5927\u8111\u76ae\u8d28\u901a\u8fc7\u4e0b\u884c\u6295\u5c04\u7ea4\u7ef4\u4f20\u64ad\u5230\u4e18\u8111\u548c\u4e2d\u8111\u7f51\u72b6\u7ed3\u6784\uff0c\u5f15\u8d77\u610f\u8bc6\u4e27\u5931\uff0c\u518d\u7531\u5f25\u6563\u6027\u4e18\u8111\u6295\u5c04\u7cfb\u7edf\u4f20\u5e03\u5230\u6574\u4e2a\u5927\u8111\u76ae\u8d28\uff0c\u4ea7\u751f\u7ee7\u53d1\u7684\u5168\u9762\u6027\u5f3a\u76f4\u4e00\u9635\u631b\u53d1\u4f5c\u3002        \u766b\u75eb\u53d1\u4f5c\u65f6\u8111\u7535\u6ce2\u95ea\u7535\u6d3b\u52a8    2. \u766b\u75eb\u75c5\u7684\u5206\u7c7b\u548c\u7279\u70b9    \u766b\u75eb\u53d1\u4f5c\u6309\u7167\u53d1\u4f5c\u7684\u7c7b\u578b\uff0c\u5206\u4e3a\u4ee5\u4e0b\u51e0\u7c7b\u3002        \u766b\u75eb\u75c5\u6709\u4e09\u5927\u7279\u70b9\uff1a\u5177\u6709\u7a81\u53d1\u6027\uff0c\u6682\u65f6\u6027\u548c\u53cd\u590d\u53d1\u4f5c\u6027\u3002    3.\u7406\u60f3\u7684\u6297\u766b\u75eb\u836f\u7269    \u766b\u75eb\u662f\u4e00\u79cd\u6162\u6027\u75c5\uff0c\u9700\u8981\u957f\u671f\u7684\u836f\u7269\u6cbb\u7597\u3002\u56e0\u6b64\uff0c\u533b\u52a1\u5de5\u4f5c\u8005\u4e00\u76f4\u5728\u5bfb\u627e\u7406\u60f3\u7684\u6297\u766b\u75eb\u836f\u7269\u3002\u5b83\u5e94\u8be5\u5177\u6709\u6297\u766b\u75eb\u8c31\u5e7f\uff0c\u6297\u766b\u75eb\u5f3a\u5ea6\uff0c\u6297\u766b\u75eb\u7597\u6548\u9ad8\uff0c\u6bd2\u526f\u4f5c\u7528\u5c0f\uff0c\u4ef7\u683c\u8f83\u4f4e\u5ec9\uff0c\u6765\u8f83\u4e30\u5bcc\u7b49\u4f18\u70b9\u3002\u7136\u800c\u76ee\u524d\u4e3a\u6b62\u5c1a\u65e0\u4e00\u79cd\u836f\u7269\u80fd\u591f\u5927\u81f4\u8fd9\u79cd\u6807\u51c6\uff0c\u5305\u62ec\u4e2d\u836f\u5728\u5185\u3002\u56e0\u6b64\uff0c\u5728\u9009\u62e9\u5e94\u7528\u6297\u766b\u75eb\u836f\u7269\u65f6\uff0c\u8981\u6743\u8861\u5229\u5f0a\uff0c\u7efc\u5408\u8003\u8651\u3002\u5c3d\u91cf\u8fbe\u5230\u63a7\u5236\u53d1\u4f5c\u7684\u76ee\u7684\uff0c\u53c8\u80fd\u5c06\u6bd2\u526f\u4f5c\u7528\u964d\u4f4e\u5230\u6700\u5c0f\u3002    4.\u6297\u766b\u75eb\u836f\u7269\u7684\u5206\u7c7b        \u82ef\u59a5\u82f1\u94a0\u662f\u4ece\u5df4\u6bd4\u59a5\u7c7b\u836f\u7269\u7684\u7ed3\u6784\u6539\u9020\u800c\u6765\u7684\u836f\u7269\uff0c\u4e0e\u5df4\u6bd4\u59a5\u7c7b\u76f8\u6bd4\uff0c\u73af\u4e0a\u5c11\u4e00\u4e2a\u7fb0\u57fa\uff0c\u4e3a\u4e94\u5143\u73af\u7684\u4e59\u5185\u9170\u8132\u3002\u6839\u636e\u5df4\u6bd4\u59a5\u7c7b\u836f\u7269\u7684\u7ed3\u6784\u6539\u9020\u8fd8\u5f97\u5230\u4e00\u4e9b\u836f\u7269\uff0c\u901a\u79f0\u4e3a\u73af\u5185\u9170\u8132\u7c7b\u6297\u766b\u75eb\u836f\u7269\u3002<\/p>\n<\/p>\n

    5.\u4ee3\u8868\u836f\u7269    \u5df4\u6bd4\u59a5\u7c7b\u548c\u82ef\u5e76\u6c2e\u5353\u7c7b\u4e2d\u7684phenobarbital\u548cdiazepam\u3001clonazepam\u7b49\u836f\u7269\u5728\u4e34\u5e8a\u4e2d\u5e7f\u6cdb\u5730\u7528\u4e8e\u6297\u766b\u75eb\uff0c\u5df2\u5728\u9547\u9759\u50ac\u7720\u836f\u4e2d\u4ecb\u7ecd\u3002\u5176\u4ed6\u5e38\u7528\u7684\u6297\u766b\u75eb\u836f\u7269\u6709\u82ef\u59a5\u82f1\u94a0\u3001\u5361\u9a6c\u897f\u5e73\u548c\u4e19\u620a\u9178\u94a0\u7b49\u3002    \u82ef\u59a5\u82f1\u94a0\uff08sodium phenytoin\uff09<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3a5,5-\u4e8c\u82ef\u57fa-2,4-\u54aa\u5511\u70f7\u4e8c\u916e\u94a0\u76d0(5,5-diphenyl-2,4-imidazolidinedione sodium)\uff0c\u53c8\u540d\u5927\u4f26\u4e01\u94a0\uff08dilantin sodium\uff09\u3002    \uff081\uff09 \u7406\u5316\u6027\u8d28    \u82ef\u59a5\u82f1\u94a0\u5fae\u6709\u5f15\u6e7f\u6027\uff1b\u5728\u7a7a\u6c14\u4e2d\u6e10\u6e10\u5438\u6536\u4e8c\u6c27\u5316\u78b3\uff0c\u5206\u89e3\u6210\u82ef\u59a5\u82f1\u3002\u82ef\u59a5\u82f1\u7684\u7ed3\u6784\u7c7b\u4f3c\u82ef\u5df4\u6bd4\u59a5\uff0c\u5177\u73af\u72b6\u9170\u8132\u7684\u7ed3\u6784\u3002\u53ef\u56e0\u4e92\u53d8\u5f02\u6784\u6210\u4e9a\u80fa\u9187\u5f0f\uff0c\u800c\u663e\u9178\u6027\uff0cpKa\u7ea68.3\u3002sodium phenytoin\u6c34\u6eb6\u6db2\u663e\u78b1\u6027\u53cd\u5e94\u3002\u5e38\u56e0\u90e8\u5206\u6c34\u89e3\u800c\u53d1\u751f\u6d51\u6d4a\uff0c\u6545\u672c\u54c1\u5e94\u5bc6\u95ed\u4fdd\u5b58\u3002<\/p>\n<\/p>\n

    \u82ef\u59a5\u82f1\u94a0\u4e0e\u78b1\u52a0\u70ed\uff0c\u73af\u72b6\u9170\u8132\u7ed3\u6784\u5f00\u73af\uff0c\u5206\u89e3\u4ea7\u751f\u4e8c\u82ef\u57fa\u8132\u57fa\u4e59\u9178\uff0c\u6700\u540e\u751f\u6210\u4e8c\u82ef\u57fa\u6c28\u57fa\u4e59\u9178\uff0c\u5e76\u91ca\u653e\u51fa\u6c28\u3002\uff08\u53ef\u4f9b\u9274\u522b\uff09<\/p>\n<\/p>\n

    \u82ef\u59a5\u82f1\u94a0\u7684\u836f\u7269\uff0c\u4e0e\u94f6\u76d0\u53cd\u5e94\uff0c\u6240\u5f97\u6c89\u6dc0\u4e0d\u6eb6\u4e8e\u6c28\u8bd5\u6db2\u4e2d\u3002<\/p>\n<\/p>\n

    \u82ef\u59a5\u82f1\u94a0\u7684\u6c34\u6eb6\u6db2\u4e2d\u52a0\u5165\u4e8c\u6c2f\u5316\u6c5e\u8bd5\u6db2\uff0c\u53ef\u751f\u6210\u767d\u8272\u6c89\u6dc0\uff0c\u5728\u6c28\u8bd5\u6db2\u4e2d\u4e0d\u6eb6\u3002\u5df4\u6bd4\u59a5\u7c7b\u7684\u836f\u7269\uff0c\u867d\u4e5f\u6709\u6c5e\u76d0\u53cd\u5e94\uff0c\u4f46\u6240\u5f97\u6c89\u6dc0\u6eb6\u4e8e\u6c28\u8bd5\u6db2\u4e2d\uff0c\u53ef\u4ee5\u533a\u522b\u3002<\/p>\n<\/p>\n

    \u82ef\u59a5\u82f1\u94a0\u7684\u6c34\u6eb6\u6db2\u4e0e\u5421\u5576\u786b\u9178\u94dc\u6eb6\u6db2 \u4f5c\u7528\u751f\u6210\u84dd\u8272\u7edc\u76d0 \uff08\u7528\u4e8e\u9274\u522b\u82ef\u59a5\u82f1\u94a0\u4e0e\u5df4\u6bd4\u59a5\u7c7b\u836f\u7269\uff09\u3002    \uff082\uff09 \u4f53\u5185\u4ee3\u8c22    \u82ef\u59a5\u82f1\u94a0\u5728\u809d\u810f\u4ee3\u8c22\uff0c\u4ee3\u8c22\u7269\u4e3b\u8981\u4e3a\u65e0\u6d3b\u6027\u76845-(4-\u7f9f\u57fa\u82ef\u57fa)-5-\u82ef\u4e59\u5185\u9170\u8132\u3002\u5b83\u4e0e\u8461\u8404\u7cd6\u919b\u9178\u7ed3\u5408\u6392\u51fa\u4f53\u5916\u3002\u7ea620%\u4ee5\u539f\u5f62\u7531\u5c3f\u6392\u51fa\uff0c\u5728\u78b1\u6027\u5c3f\u4e2d\u6392\u6cc4\u8f83\u5feb\u3002\u672c\u54c1\u662f\u809d\u9176\u7684\u5f3a\u8bf1\u5bfc\u5242\uff0c\u53ef\u4f7f\u5408\u5e76\u5e94\u7528\u7684\u4e00\u4e9b\u836f\u7269\u7684\u4ee3\u8c22\u52a0\u5feb\uff0c\u8840\u836f\u6d53\u5ea6\u964d\u4f4e\u3002<\/p>\n<\/p>\n

    \u82ef\u59a5\u82f1\u94a0\u4e3a\u6cbb\u7597\u766b\u75eb\u5927\u53d1\u4f5c\u548c\u5c40\u9650\u6027\u53d1\u4f5c\u7684\u4e3b\u8981\u7528\u836f\uff0c\u5bf9\u5c0f\u53d1\u4f5c\u65e0\u6548\u3002    6\uff0e\u4ee3\u8868\u836f\u7269    \u5361\u9a6c\u897f\u5e73\u3000carbamazepine<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3a5H-\u4e8c\u82ef\u5e76\uff3bb,f\uff3d\u6c2e\u6742zaozi001-5-\u7532\u9170\u80fa(5H-dibenz[b,f]azepine-5- carboxamide)\u3002\u53c8\u79f0\u9170\u80fa\u54aa\u55ea\u3001\u5361\u5df4\u54aa\u55ea\u3002<\/p>\n

    <\/p>\n

    \u5361\u9a6c\u897f\u5e73\u7684\u7a7a\u95f4\u6784\u578b<\/p>\n

    \u7ed3\u6784\u7279\u70b9\uff1a    2\u4e2a\u82ef\u73af\u4e0e\u6c2e\u6742\u73af\u9a88\u5408\u800c\u6210\u7684\u4e8c\u82ef\u5e76\u6c2e\u6742\u5353\u7c7b\u5316\u5408\u7269\uff0c\u4e8c\u4e2a\u82ef\u73af\u901a\u8fc7\u70ef\u952e\u76f8\u8fde\u5f62\u6210\u5171\u8f6d\u4f53\u7cfb\u5177\u6709\u5c3f\u7d20\u7684\u7ed3\u6784\u3002    \u7406\u5316\u6027\u8d28\uff1a    \u5728\u5e72\u71e5\u72b6\u6001\u53ca\u5ba4\u6e29\u4e0b\u8f83\u7a33\u5b9a\u3002\u7247\u5242\u5728\u6f6e\u6e7f\u73af\u5883\u4e2d\u4fdd\u5b58\u65f6\uff0c\u836f\u6548\u964d\u81f3\u539f\u6765\u76841\/3\u3002\u53ef\u80fd\u662f\u7531\u4e8e\u751f\u6210\u4e8c\u6c34\u5408\u7269\u4f7f\u7247\u5242\u786c\u5316\uff0c\u5bfc\u81f4\u6eb6\u89e3\u548c\u5438\u6536\u5dee\u6240\u81f4\u3002    \u957f\u65f6\u95f4\u5149\u7167\uff0c\u56fa\u4f53\u8868\u9762\u7531\u767d\u53d8\u6a59\u9ec4\u8272<\/p>\n<\/p>\n

    \u5728\u809d\u810f\u5e7f\u6cdb\u4ee3\u8c22\uff0c\u4ee3\u8c22\u726910\uff0c11-\u73af\u6c27\u5361\u9a6c\u897f\u5e73\u4ecd\u5177\u6d3b\u6027\uff0c\u5728\u8840\u6d46\u548c\u8111\u4e2d\u7684\u6d53\u5ea6\u53ef\u8fbe\u539f\u836f\u768450%\u3002\u8be5\u4ee3\u8c22\u7269\u8fdb\u4e00\u6b65\u7f9f\u57fa\u5316\uff0c\u7ed3\u5408\u6210\u65e0\u6d3b\u6027\u7684\u8461\u8404\u7cd6\u919b\u9178\u82f7\uff0c\u81ea\u5c3f\u4e2d\u6392\u51fa\u3002<\/p>\n<\/p>\n

    \u5408\u6210\u8def\u7ebf\uff1a    \u5361\u9a6c\u897f\u5e73\u7684\u5408\u6210\u53ef\u4ece5H-10\uff0c11-\u4e8c\u6c22\u4e8c\u82ef\u5e76[b\uff0cf]\u6c2e\u6742\u5353\u51fa\u53d1\uff0c\u7ecf5\u4f4d\u6c2f\u7532\u9170\u5316\u300110\u4f4d\u6eb4\u4ee3\u3001\u8131HBr\u548c\u6c28\u89e3\u7b49\u4e00\u7cfb\u5217\u53cd\u5e94\u800c\u5f97\u3002<\/p>\n<\/p>\n

    \u4e34\u5e8a\u7528\u9014\uff1a    \u7528\u4e8e\u6cbb\u7597\u766b\u75eb\u5927\u53d1\u4f5c\u548c\u7efc\u5408\u6027\u5c40\u7076\u6027\u53d1\u4f5c\u3002\u662f\u4e34\u5e8a\u4e0a\u4e3b\u8981\u5e94\u7528\u7684\u836f\u7269\u3002    \u603b\u7ed3\uff1a    1\u3001\u6297\u766b\u75eb\u836f\u7684\u7ed3\u6784\u7c7b\u578b    2\u3001\u82ef\u59a5\u82f1\u94a0\u7684\u7ed3\u6784\u3001\u547d\u540d\u53ca\u4e34\u5e8a\u7528\u9014\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

 1. \u766b\u75eb\u75c5    \u766b\u75eb\u662f\u7531\u4e8e\u5927\u8111\u5c40\u90e8 … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-44591","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/44591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44591"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/44591\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44591"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}