{"id":44588,"date":"2024-12-05T05:10:55","date_gmt":"2024-12-05T05:10:55","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=44588"},"modified":"2024-12-05T05:10:55","modified_gmt":"2024-12-05T05:10:55","slug":"%e7%ac%ac%e4%ba%8c%e8%8a%82-%e9%9d%9e%e7%94%be%e4%bd%93%e6%8a%97%e7%82%8e%e8%8d%af","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=44588","title":{"rendered":"\u7b2c\u4e8c\u8282 \u975e\u753e\u4f53\u6297\u708e\u836f"},"content":{"rendered":"<\/p>\n

   <\/p>\n

    \u708e\u75c7\u662f\u673a\u4f53\u5bf9\u611f\u67d3\u7684\u4e00\u79cd\u9632\u5fa1\u673a\u5236\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u7ea2\u80bf\uff0c\u75bc\u75db\u7b49\u3002\u708e\u75c7\u7684\u53d1\u751f\u76f8\u5f53\u590d\u6742\uff0c\u4e00\u822c\u8ba4\u4e3a\u662f\u5f53\u7ec6\u80de\u819c\u53d7\u5230\u67d0\u79cd\u708e\u6027\u523a\u6fc0\u65f6\uff0c\u5bfc\u81f4\u7ec6\u80de\u819c\u529f\u80fd\u7d0a\u4e71\uff0c\u78f7\u8102\u9176A2\uff08PLA2)\u88ab\u6fc0\u6d3b\uff0c\u50ac\u5316\u6c34\u89e3\u7ec6\u80de\u5185\u819c\u78f7\u8102\u4e0a\u7684\u82b1\u751f\u56db\u70ef\u9178\uff08AA\uff09\u90e8\u5206\u8f6c\u5316\u6210\u4e3a\u6e38\u79bb\u72b6\u6001\u7684AA\uff0c\u91ca\u653e\u51fa\u7684AA\u7ecf\u8fc7\u73af\u6c27\u5316\u9176\uff08COX\uff09\u548c5-\u8102\u6c27\u9176\uff085-LO\uff09\u4e24\u6761\u9014\u5f84\u8fdb\u884c\u4ee3\u8c22\u3002\u4ea7\u51fa\u5927\u91cf\u7684\u524d\u5217\u817a\u7d20\uff08PGS\uff09\u548c\u767d\u4e09\u70ef\uff08LTs\uff09\u7b49\u708e\u75c7\u4ecb\u8d28\uff0c\u4ece\u800c\u5bfc\u81f4\u708e\u75c7\u7684\u53d1\u751f\u3002<\/p>\n

    \u6309\u5316\u5b66\u7ed3\u6784\u4e0d\u540c\uff0c\u975e\u753e\u4f53\u6297\u708e\u836f\u53ef\u5206\u4e3a\uff1a    1\u3001\u5421\u5511\u916e\u7c7b\uff1a\u7f9f\u5e03\u5b97    2\u3001\u5432\u54da\u4e59\u9178\u7c7b\uff1a\u5432\u54da\u7f8e\u8f9b    3\u3001\u90bb\u6c28\u57fa\u82ef\u7532\u9178\u7c7b\uff1a\u7532\u82ac\u90a3\u9178    4\u3001\u82ef\u4e59\u9178\u7c7b\uff1a\u53cc\u6c2f\u82ac\u9178\u94a0    5\u3001\u82b3\u57fa\u4e19\u9178\u7c7b\uff1a\u5e03\u6d1b\u82ac\u3001\u8418\u666e\u751f    6\u30011\uff0c2-\u82ef\u5e76\u567b\u55ea\u7c7b\uff1a\u5421\u7f57\u6614\u5eb7    \u4e00\u3001\u5421\u5511\u916e\u7c7b    \uff08\u4e00\uff09\u53d1\u5c55\u53f2\uff1a    1\u30011884\u5e74\u5fb7\u56fd\u5316\u5b66\u5bb6Ludury Knorr\u5408\u6210\u7684\u5b89\u66ff\u6bd4\u6797\uff08antipyrine\uff0cphenazone\uff09    2\u3001\u5728phenazone\u5206\u5b50\u4e2d\u5f15\u5165\u4e8c\u7532\u6c28\u57fa\uff0c\u5408\u6210\u4e86\u6c28\u57fa\u6bd4\u6797\uff08aminophenazone\uff09\uff0c\u5176\u89e3\u70ed\u9547\u75db\u4f5c\u7528\u6bd4phenazone\u4f18\u826f\uff0c\u4f46\u4f5c\u7528\u7a0d\u6162\u3002    3\u3001\uff0c\u5728aminophenazone\u7684\u5206\u5b50\u4e2d\u5f15\u5165\u6c34\u6eb6\u6027\u57fa\u56e2\u4e9a\u7532\u57fa\u78fa\u9178\u94a0\uff0c\u5f97\u5230\u5b89\u4e43\u8fd1\uff08metamizole sodium\uff09\u3002\u867d\u7136\u5176\u6bd2\u6027\u8f83\u4f4e\uff0c\u4f46\u4ecd\u53ef\u5f15\u8d77\u7c92\u7ec6\u80de\u7f3a\u4e4f\u75c7\uff0c\u52a0\u4e4b\u5176\u7a33\u5b9a\u6027\u95ee\u9898\uff0c\u9650\u5236\u5176\u4f7f\u7528\u3002    4\u30011946\u5e74\u5408\u6210\u5177\u67093,5-\u5421\u5511\u70f7\u4e8c\u916e\u7ed3\u6784\u7684\u4fdd\u6cf0\u677e\u4f46\u5176\u6bd2\u526f\u4f5c\u7528\u4ecd\u8f83\u5927\uff0c\u9664\u80c3\u80a0\u9053\u526f\u4f5c\u7528\u53ca\u8fc7\u654f\u53cd\u5e94\u5916\uff0c\u5bf9\u809d\u53ca\u8840\u8c61\u6709\u4e0d\u826f\u7684\u5f71\u54cd\u3002    5\u30011961\u5e74\u53d1\u73b0phenylbutazone\u4f53\u5185\u7684\u4ee3\u8c22\u7269\u7f9f\u5e03\u5b97\uff08oxyphenbutazone\uff09\uff0c\u540c\u6837\u5177\u6709\u6d88\u708e\u6297\u98ce\u6e7f\u4f5c\u7528\uff0c\u4e14\u6bd2\u6027\u4f4e\uff0c\u526f\u4f5c\u7528\u5c0f\u3002    \uff08\u4e8c\uff09\u4ee3\u8868\u836f\u7269\uff1a\u7f9f\u5e03\u5b97    1\u3001\u7ed3\u6784\u548c\u547d\u540d\uff1a<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3a4-\u4e01\u57fa-1-(4-\u7f9f\u57fa\u82ef\u57fa)-2-\u82ef\u57fa-3,5-\u5421\u5511\u70f7\u4e8c\u916e(4-butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione)\u3002    2\u3001\u7406\u5316\u6027\u8d28\uff1a    \uff081\uff09\u9178\u6027\uff1a3,5-\u5421\u5511\u70f7\u4e8c\u916e\u7c7b\u836f\u7269\u7684\u6297\u708e\u4f5c\u7528\u4e0e\u5316\u5408\u7269\u7684\u9178\u6027\u6709\u5bc6\u5207\u5173\u7cfb\u30023\uff0c5\u4f4d\u7684\u4e8c\u7fb0\u57fa\u589e\u5f3a4-\u4f4d\u7684\u6c22\u539f\u5b50\u9178\u6027\uff0c\u8fd9\u5f52\u56e0\u4e8e\u5b58\u5728\u5982\u4e0b\u5171\u632f\u5f0f\uff1a<\/p>\n<\/p>\n

    \uff082\uff09\u9274\u522b\u53cd\u5e94\uff1aoxyphenbutazone\u4e0e\u51b0\u918b\u9178\u53ca\u76d0\u9178\u5171\u70ed\uff0c\u6c34\u89e3\u751f\u62104-\u7f9f\u57fa\u6c22\u5316\u5076\u6c2e\u82ef\uff0c\u968f\u5373\u8f6c\u4f4d\u91cd\u6392\uff0c\u751f\u62102,4-\u4e8c\u6c28\u57fa\u8054\u82ef\u915a\u548c\u5bf9-\u7f9f\u57fa\u90bb\u6c28\u57fa\u82ef\u80fa\u3002\u5747\u4e0e\u4e9a\u785d\u9178\u94a0\u8bd5\u6db2\u4f5c\u7528\u751f\u6210\u9ec4\u8272\u91cd\u6c2e\u76d0\uff0c\u518d\u4e0e\u03b2-\u8418\u915a\u5076\u5408\u751f\u6210\u6a59\u8272\u6c89\u6dc0\u3002<\/p>\n<\/p>\n

    3\u3001\u4f53\u5185\u4ee3\u8c22\uff1a<\/p>\n<\/p>\n

    4\u3001\u6784\u6548\u5173\u7cfb\uff1a<\/p>\n<\/p>\n

    \u4e8c\u3001\u90bb\u6c28\u57fa\u82ef\u7532\u9178\u7c7b    \u4ee3\u8868\u836f\u7269\uff1a\u7532\u82ac\u90a3\u9178<\/p>\n<\/p>\n

    1\u3001\u7ed3\u6784\u548c\u547d\u540d\uff1a<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3aN-[(2,3-\u4e8c\u7532\u57fa\u82ef\u57fa)\u6c28\u57fa]-\u82ef\u7532\u9178(2-[(2,3-dimethylphenyl)amino] benzoic acid)\u3002    2\u3001\u7406\u5316\u6027\u8d28\uff1a    \uff081\uff09\u6c2f\u4eff\u6eb6\u6db2\u5728\u7d2b\u5916\u706f\u4e0b\u5448\u5f3a\u70c8\u7eff\u8272\u8367\u5149\uff1b    \uff082\uff09\u672c\u54c1\u7684\u786b\u9178\u6eb6\u6db2\uff0c\u4e0e\u91cd\u94ec\u9178\u94be\u53cd\u5e94\uff0c\u663e\u6df1\u84dd\u8272\uff0c\u968f\u5373\u53d8\u4e3a\u68d5\u7eff\u8272\u3002    3\u3001\u6784\u6548\u5173\u7cfb\uff1a    \uff081\uff09\u82ef\u73af\u4e0e\u90bb\u6c28\u57fa\u82ef\u7532\u9178\u7684\u975e\u5171\u5e73\u9762\u7ed3\u6784\u66f4\u9002\u5408\u4e0e\u53d7\u4f53\u7ed3\u5408\uff1b    \uff082\uff09N\u4ee5S\u3001O\u3001CH2\uff0cSO2\uff0cNCH3\uff0cCOCH3\u7f6e\u6362\uff0c\u6d3b\u6027\u964d\u4f4e\uff1b    \uff083\uff09\u5c06-NH2\u79fb\u5230\u95f4\u3001\u5bf9\u4f4d\uff0c\u4e0e\u6c34\u6768\u9178\u7684\u7ed3\u6784\u76f8\u4f3c\u6027\u964d\u4f4e\uff0c\u6d3b\u6027\u6d88\u5931\u3002    \u4e09\u3001\u5432\u54da\u4e59\u9178\u7c7b    \u4ee3\u8868\u836f\u7269\uff1a\u5432\u54da\u7f8e\u8f9b    1\u3001\u7ed3\u6784\u548c\u547d\u540d\uff1a<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3a2-\u7532\u57fa-1-(4-\u6c2f\u82ef\u7532\u9170\u57fa)-5-\u7532\u6c27\u57fa-1H-\u5432\u54da-3-\u4e59\u9178(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid)\u3002    2\u3001\u7406\u5316\u6027\u8d28\uff1a    \uff081\uff09\u9178\u6027\uff1a<\/p>\n<\/p>\n

    \uff082\uff09\u7a33\u5b9a\u6027\uff1a\u5728\u5ba4\u6e29\u4e0b\u7a7a\u6c14\u4e2d\u7a33\u5b9a\uff0c\u4f46\u5bf9\u5149\u654f\u611f\u3002\u6c34\u6eb6\u6db2\u5728pH2~8\u65f6\u8f83\u7a33\u5b9a\u3002    \uff083\uff09\u6c34\u89e3\uff1a\u53ef\u88ab\u5f3a\u9178\u6216\u5f3a\u78b1\u6c34\u89e3\uff0c\u751f\u6210\u5bf9\u6c2f\u82ef\u7532\u9178\u548c5-\u7532\u6c27\u57fa-2-\u7532\u57fa\u5432\u54da-3-\u4e59\u9178\uff0c\u540e\u8005\u8131\u7fa7\u751f\u62105-\u7532\u6c27\u57fa-2\uff0c3-\u4e8c\u7532\u57fa\u5432\u54da\uff0c\u8fd9\u4e9b\u90fd\u53ef\u4ee5\u88ab\u6c27\u5316\u6210\u6709\u8272\u7269\u8d28\u3002<\/p>\n<\/p>\n

    \uff084\uff09\u9274\u522b\u53cd\u5e94\uff1a    A\u3001\u672c\u54c1\u7684\u6c22\u6c27\u5316\u94a0\u6eb6\u6db2\u4e0e\u91cd\u94ec\u9178\u94be\u6eb6\u6db2\u548c\u786b\u9178\u53cd\u5e94\uff0c\u5448\u7d2b\u8272    B\u3001\u4e0e\u4e9a\u785d\u9178\u94a0\u548c\u76d0\u9178\u53cd\u5e94\uff0c\u5448\u7eff\u8272\uff0c\u653e\u7f6e\u540e\u6e10\u53d8\u9ec4\u8272\u3002    3\u3001\u4f53\u5185\u4ee3\u8c22\uff1a<\/p>\n<\/p>\n

    4\u3001\u5408\u6210\u8def\u7ebf\uff1a<\/p>\n<\/p>\n

    5\u3001\u4e34\u5e8a\u7528\u9014\uff1a    indomethacin\u662f\u4e00\u4e2a\u5f3a\u529b\u7684\u9547\u75db\u6d88\u708e\u836f\uff0c\u4e34\u5e8a\u4e0a\u7528\u4e8e\u6cbb\u7597\u98ce\u6e7f\u6027\u548c\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3002    \u56db\u3001\u82b3\u57fa\u4e19\u9178\u7c7b    \uff08\u4e00\uff09\u5e03\u6d1b\u82ac\uff1a    1\u3001\u7ed3\u6784\u548c\u547d\u540d\uff1a<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u03b1-\u7532\u57fa-4-(2-\u7532\u57fa\u4e19\u57fa)\u82ef\u4e59\u9178(\u03b1-methyl-4-(2-methylpropyl)benzeneacetic acid)\uff0c\u522b\u540d\uff1a\u5f02\u4e01\u82ef\u4e19\u9178\u3002    2\u3001\u7406\u6027\u6027\u8d28\uff1a    \uff081\uff09\u6709\u4e00\u4e2a\u624b\u6027\u78b3\uff0c\u836f\u7528\u5916\u6d88\u65cb\u4f53\uff1b    \uff082\uff09\u6709\u9178\u6027\uff1b    3\u3001\u4f53\u5185\u4ee3\u8c22\uff1a    \u5176\u4ee3\u8c22\u4e3b\u8981\u53d1\u751f\u5728\u5f02\u4e01\u57fa\u7684\u03c9-1\u548c\u03c9-2\u6c27\u5316\uff0c\u9996\u5148\u6c27\u5316\u4e3a\u9187\uff0c\u518d\u6c27\u5316\u4e3a\u9178\u3002\u6240\u6709\u7684\u4ee3\u8c22\u7269\u90fd\u5931\u6d3b\u3002\u65e0\u8bba\u670d\u7528ibuprofen\u7684\u54ea\u79cd\u5f02\u6784\u4f53\uff0c\u5176\u4e3b\u8981\u4ee3\u8c22\u4ea7\u7269\u4e3aS\uff08\uff0b\uff09-\u6784\u578b\u3002\u66f4\u6709\u8da3\u7684\u662fR\uff08\uff0d\uff09\u5f02\u6784\u4f53\u5728\u4f53\u5185\u53ef\u4ee5\u8f6c\u5316\u4e3aS\uff08\uff0b\uff09-\u5f02\u6784\u4f53\u3002    4\u3001\u5408\u6210\u8def\u7ebf\uff1a<\/p>\n<\/p>\n

    5\u3001\u6784\u6548\u5173\u7cfb\uff1a<\/p>\n<\/p>\n

    \uff08\u4e8c\uff09\u8418\u666e\u751f\uff1a    1\u3001\u7ed3\u6784\u548c\u547d\u540d\uff1a<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3a(\uff0b)-\u03b1-\u7532\u57fa-6-\u7532\u6c27\u57fa-2-\u8418\u4e59\u9178((\u03b1S)-6-methoxy-\u03b1-methyl- 2-naphthaleneacetic acid)\u3002    2\u3001\u7406\u5316\u6027\u8d28\uff1a    \uff081\uff09\u542b\u4e00\u4e2a\u624b\u6027\u78b3\uff0c\u4e34\u5e8a\u4e0a\u4f7f\u7528S\uff08+\uff09    \uff082\uff09\u9178\u6027\uff1b    3\u3001\u6784\u6548\u5173\u7cfb\uff1a    1\u3001-OCH3\uff1a\uff081\uff09\u79fb\u81f3\u5176\u4ed6\u4f4d\u7f6e\uff0c\u6d3b\u6027\u964d\u4f4e\uff1b    \uff082\uff09\u4ee5\u5c0f\u7684\u4eb2\u8102\u6027\u57fa\u56e2Cl, CH3, F2CHO\u7b49\u53d6\u4ee3\uff0c\u6d3b\u6027\u4fdd\u7559\uff1b    \uff083\uff09\u4ee5\u8f83\u5927\u57fa\u56e2\u53d6\u4ee3\uff0c\u6d3b\u6027\u964d\u4f4e\u3002    2\u3001-COOH\uff1a\u4ee5-OH,-CHO,-C0-\u7b49\u53d6\u4ee3\uff0c\u6297\u708e\u6d3b\u6027\u4fdd\u7559\u3002    \u4e94\u3001\u82ef\u4e59\u9178\u7c7b    \u4ee3\u8868\u836f\u7269\uff1a\u53cc\u6c2f\u82ac\u9178\u94a0    1\u3001\u7ed3\u6784\u548c\u547d\u540d\uff1a<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3a2-[(2,6-\u4e8c\u6c2f\u82ef\u57fa)\u6c28\u57fa]\u82ef\u4e59\u9178\u94a0(sodium 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid)\u3002    2\u3001\u4f5c\u7528\u673a\u5236\uff1a    \u2460\u6291\u5236\u82b1\u751f\u56db\u70ef\u9178\u73af\u6c27\u9176\u7cfb\u7edf\uff0c\u5bfc\u81f4prostaglandins\u548c\u8840\u5c0f\u677f\u751f\u6210\u7684\u51cf\u5c11\u3002    \u2461\u6291\u5236\u8102\u6c27\u9176\uff0c\u8be5\u9176\u80fd\u5bfc\u81f4\u767d\u4e09\u70ef\u7684\u751f\u6210\uff0c\u7279\u522b\u5bf9\u767d\u4e09\u70efB4\u7684\u6291\u5236\u4f5c\u7528\u66f4\u5f3a\u3002    \u2462\u6291\u5236\u82b1\u751f\u56db\u70ef\u9178\u7684\u91ca\u653e\u548c\u523a\u6fc0\u82b1\u751f\u56db\u70ef\u9178\u7684\u518d\u6444\u5165\uff0c\u7ed3\u679c\u5bfc\u81f4\u82b1\u751f\u56db\u70ef\u9178\u6570\u91cf\u7684\u51cf\u5c11\u3002    \u516d\u30011\uff0c2-\u82ef\u5e76\u567b\u55ea\u7c7b    \u4ee3\u8868\u836f\u7269\uff1a\u5421\u7f57\u6614\u5eb7    1\u3001\u7ed3\u6784\u548c\u547d\u540d\uff1a<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3a2-\u7532\u57fa-4-\u7f9f\u57fa-N-(2-\u5421\u5576\u57fa)-2H-1,2-\u82ef\u5e76\u567b\u55ea-3-\u7532\u9170\u80fa-1,1-\u4e8c\u6c27\u5316\u7269(4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide)\u3002\u522b\u540d\u708e\u75db\u6614\u5eb7\u3002    2\u3001\u7406\u5316\u6027\u8d28\uff1a    \uff081\uff09\u9178\u6027\uff1a    \uff082\uff09\u6c2f\u4eff\u6eb6\u6db2\u4e0e\u4e09\u6c2f\u5316\u94c1\u53cd\u5e94\uff0c\u663e\u73ab\u7470\u7ea2\u8272\u3002    \u4e03\u3001\u9009\u62e9\u6027COX-2\u6291\u5236\u5242    NSAIDs\u662f\u4e34\u5e8a\u4e0a\u5e94\u7528\u6700\u5e7f\u6cdb\u7684\u4e00\u7c7b\u5177\u6709\u6297\u708e\u3001\u9547\u75db\u548c\u89e3\u70ed\u4f5c\u7528\u7684\u836f\u7269\uff0c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u98ce\u6e7f\u6027\u3001\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u9aa8\u5173\u8282\u708e\u7b49\u708e\u75c7\u514d\u75ab\u6027\u75be\u75c5\u3002\u4f46\u56e0\u5176\u53ef\u4ee5\u6291\u5236\u73af\u6c27\u5316\u9176\uff08COX\uff09\uff0c\u4ece\u800c\u6291\u5236\u708e\u75c7\u90e8\u4f4dPGs\u751f\u7269\u5408\u6210\u7684\u540c\u65f6\uff0c\u53c8\u5bf9\u5177\u6709\u7c98\u819c\u4fdd\u62a4\u4f5c\u7528\u7684\u751f\u7406\u6027PGs\u4ea7\u751f\u6291\u5236\uff0c\u6240\u4ee5\u957f\u671f\u670d\u7528\u53ef\u80fd\u5bfc\u81f4\u80c3\u80a0\u9053\u526f\u4f5c\u7528\uff0c\u4e25\u91cd\u65f6\u4f1a\u5f15\u53d1\u80c3\u80a0\u9053\u5e76\u53d1\u75c7\u7b49\uff0c\u4e25\u91cd\u5730\u963b\u788d\u4e86\u8fd9\u7c7b\u836f\u7269\u7684\u53d1\u5c55\u3002    \u8fd1\u5e74\u6765\u53d1\u73b0\uff0cCOX\u81f3\u5c11\u6709\u4e24\u79cd\u5f02\u6784\u4f53\u5b58\u5728\uff0c\u5373COX-1\u548cCOX-2\uff0c\u800c\u73b0\u6709\u7684\u975e\u753e\u4f53\u6297\u708e\u836f\u7684\u6297\u708e\u4f5c\u7528\u662f\u6291\u5236\u4e86COX-2\uff0c\u4e0d\u826f\u53cd\u5e94\u5219\u662f\u6291\u5236\u4e86COX-1\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u9009\u62e9\u6027COX-2\u6291\u5236\u5242\u5219\u80fd\u4e3a\u708e\u75c7\u7684\u6cbb\u7597\u5f00\u62d3\u65b0\u7684\u524d\u666f\u3002<\/p>\n<\/p>\n

    \u4ee3\u8868\u836f\u7269\uff1a\u585e\u6765\u897f\u5e03    1\u3001\u7ed3\u6784\u548c\u547d\u540d\uff1a<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3a4-[-5-(4-\u7532\u57fa\u82ef\u57fa)-3-\u4e09\u6c1f\u7532\u57fa]-1H-\u5421\u54af-1-\u57fa]\u82ef\u78fa\u9170\u80fa(4-[5-(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide)\u3002\u522b\u540dcelebrex\u3002    2\u3001\u4f53\u5185\u4ee3\u8c22\uff1a    \u5176\u4e3b\u8981\u4ee3\u8c22\u7269\u4e3a\uff1a<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"

        \u708e\u75c7 … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-44588","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/44588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44588"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/44588\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44588"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}