{"id":44584,"date":"2024-12-05T05:10:51","date_gmt":"2024-12-05T05:10:51","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=44584"},"modified":"2024-12-05T05:10:51","modified_gmt":"2024-12-05T05:10:51","slug":"%e7%ac%ac%e5%9b%9b%e8%8a%82-%e6%8a%97%e7%9c%9f%e8%8f%8c%e8%8d%af","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=44584","title":{"rendered":"\u7b2c\u56db\u8282 \u6297\u771f\u83cc\u836f"},"content":{"rendered":"<\/p>\n

    \u771f\u83cc\uff08Fungi\uff09\u662f\u4e00\u79cd\u4f4e\u7b49\u690d\u7269\uff0c\u7ea6\u6709300000\u4f59\u79cd\u3002\u771f\u83cc\u75c5\u662f\u7531\u81f4\u75c5\u771f\u83cc\u5f15\u8d77\u7684\u75be\u75c5\u3002\u533b\u7528\u771f\u83cc\u5b66\uff08Medical Mycolgy\uff09\u7814\u7a76\u53d1\u73b0\uff0c\u76ee\u524d\u5df2\u77e5\u80fd\u5f15\u8d77\u4eba\u7c7b\u75be\u75c5\u7684\u771f\u83cc\u7ea6\u6709270\u4f59\u79cd\u3002    \u4e34\u5e8a\u4e0a\u6839\u636e\u81f4\u75c5\u771f\u83cc\u6765\u6e90\u7684\u4e0d\u540c\u53ef\u5206\u4e3a\u4e24\u7c7b    \u5185\u751f\u6027(Endogenous)\u771f\u83cc\uff1a    \u6307\u672c\u6765\u5c31\u5bc4\u751f\u4e8e\u4eba\u4f53\uff0c\u5728\u6b63\u5e38\u5065\u5eb7\u4eba\u7684\u76ae\u80a4\u9ecf\u819c\u4e0a\u53ef\u68c0\u6d4b\u5230\u7684\u771f\u83cc\u3002\u6b63\u5e38\u60c5\u51b5\u4e0b\u8be5\u7c7b\u771f\u83cc\u4e0d\u81f4\u75c5\uff0c\u4f46\u5728\u4eba\u4f53\u514d\u75ab\u529b\u4f4e\u4e0b\u4e14\u9002\u4e8e\u771f\u83cc\u751f\u957f\u7e41\u6b96\u7684\u60c5\u51b5\u4e0b\uff0c\u53ef\u4ee5\u81f4\u75c5\uff0c\u88ab\u79f0\u4e3a\u6761\u4ef6\u6027\u771f\u83cc\u75c5\u6216\u673a\u4f1a\u6027\u771f\u83cc\u75c5\u3002    \u5916\u88ad\u6027(Exogenous)\u771f\u83cc\uff1a    \u5927\u591a\u5b58\u5728\u4e8e\u81ea\u7136\u754c\u91cc\uff0c\u4eba\u4f53\u82e5\u63a5\u89e6\u6b64\u7c7b\u83cc\u4f53\u53ef\u5bfc\u81f4\u611f\u67d3\u3002\u6839\u636e\u5176\u4fb5\u72af\u4eba\u4f53\u7684\u6df1\u6d45\u90e8\u4f4d\u4e0d\u540c\u53ef\u5c06\u5176\u5206\u4e3a\u6d45\u90e8\u771f\u83cc\uff08Superficial mycoses\uff09\u548c\u7cfb\u7edf\u6027\u6216\u5168\u8eab\u6027\u771f\u83cc\uff08\u53c8\u79f0\u4e3a\u6df1\u90e8\u771f\u83cc\uff09(Systemic mycoses)\u4e24\u5927\u7c7b \u3002    \u4ece\u4e16\u754c\u8303\u56f4\u6765\u770b\uff0c\u5ff5\u73e0\u83cc\u5c5e\u3001\u65b0\u751f\u9690\u7403\u83cc\u548c\u66f2\u9709\u83cc\u662f\u5f15\u53d1\u771f\u83cc\u611f\u67d3\u7684\u4e09\u5927\u4e3b\u8981\u6761\u4ef6\u81f4\u75c5\u771f\u83cc\u3002    \u6297\u771f\u83cc\u836f\u7684\u5206\u7c7b    1\u3001\u6297\u771f\u83cc\u6297\u751f\u7d20    2\u3001\u5511\u7c7b\u6297\u771f\u83cc\u836f\u7269    3\u3001\u5176\u4ed6    \u4e00\u3001\u6297\u771f\u83cc\u6297\u751f\u7d20    \u4ee3\u8868\u836f\u7269\uff1a\u4e24\u6027\u9709\u7d20B<\/p>\n<\/p>\n

    \u4e24\u6027\u9709\u7d20B\u7684\u6297\u771f\u83cc\u6d3b\u6027\u5f3a\u3001\u6297\u83cc\u8c31\u5e7f\u3001\u8d77\u6548\u5feb\uff0c\u5e76\u4e14\u53ef\u4ee5\u9759\u8109\u7ed9\u836f\u3002\u5b83\u80fd\u4e0e\u771f\u83cc\u7ec6\u80de\u819c\u4e0a\u7684\u9ea6\u89d2\u753e\u9187\u7ed3\u5408\uff0c\u4f7f\u819c\u5206\u89e3\u6216\u901a\u900f\u6027\u589e\u52a0\uff0c\u9020\u6210\u819c\u5185K+\u3001\u6838\u82f7\u9178\u3001\u6c28\u57fa\u9178\u7b49\u5916\u6ea2\uff0c\u7834\u574f\u6b63\u5e38\u4ee3\u8c22\uff0c\u5bfc\u81f4\u771f\u83cc\u6b7b\u4ea1\u3002    \uff08\u4e00\uff09\u4e34\u5e8a\u7528\u9014\uff1a    1\u3001\u4e24\u6027\u9709\u7d20B\u53ea\u7528\u4e8e\u7279\u522b\u4e25\u91cd\u7684\u6df1\u90e8\u771f\u83cc\u611f\u67d3\u4ee5\u53ca\u7528\u5176\u4ed6\u6297\u771f\u83cc\u836f\u7269\u6cbb\u7597\u65e0\u6548\u7684\u60a3\u8005\u3002    2\u3001\u4e24\u6027\u9709\u7d20B\u8fd8\u7528\u4f5c\u6297\u771f\u83cc\u836f\u7269\u7b5b\u9009\u7684\u5bf9\u7167\u836f\uff0c\u88ab\u79f0\u4e3a\u201c\u9ec4\u91d1\u5bf9\u7167\u201d\u3002    \uff08\u4e8c\uff09\u526f\u4f5c\u7528\uff1a    \u4e24\u6027\u9709\u7d20B\u526f\u4f5c\u7528\u5f88\u591a\uff0c\u6700\u4e25\u91cd\u7684\u662f\u4f4e\u8840\u94be\u548c\u672b\u68a2\u7ba1\u72b6\u9178\u4e2d\u6bd2\u3002\u5176\u5b83\u4e0d\u826f\u53cd\u5e94\u8fd8\u5305\u62ec\u53d1\u70ed\u3001\u5bd2\u98a4\u3001\u6076\u5fc3\u3001\u5455\u5410\u7b49\u3002\u8fd9\u4e9b\u90fd\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u5e94\u7528 \u3002    \u4e8c\u3001\u5511\u7c7b\u6297\u771f\u83cc\u836f    \u5511\u7c7b\u6297\u771f\u83cc\u836f\u7269\u662f\u8fd1\u5e74\u6765\u53d1\u5c55\u8d77\u6765\u7684\u4e00\u7c7b\u5408\u6210\u6297\u771f\u83cc\u836f\u7269\uff0c\u4e5f\u662f\u76ee\u524d\u4e34\u5e8a\u4e0a\u5e94\u7528\u6700\u5e7f\u6cdb\u7684\u6297\u771f\u83cc\u836f\u7269\u3002    \uff08\u4e00\uff09\u5511\u7c7b\u6297\u771f\u83cc\u836f\u7684\u5206\u7c7b    1\u3001\u54aa\u5511\u7c7b\uff1a\u514b\u9709\u7d20\u3001\u54aa\u5eb7\u5511\u3001\u76ca\u5eb7\u5511    2\u3001\u4e09\u6c2e\u5511\u7c7b\uff1a\u6c1f\u5eb7\u5511    \uff08\u4e8c\uff09\u5511\u7c7b\u6297\u771f\u83cc\u836f\u7684\u6784\u6548\u5173\u7cfb<\/p>\n<\/p>\n

    \uff08\u4e09\uff09\u4ee3\u8868\u836f\u7269\uff1a    1\u3001\u785d\u9178\u76ca\u5eb7\u5511\uff1a    \uff081\uff09\u7ed3\u6784\u548c\u547d\u540d\uff1a<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3a1-[2,4-\u4e8c\u6c2f-(4-\u6c2f\u82c4\u6c27\u57fa)\u82ef\u4e59\u57fa]\u54aa\u5511\u785d\u9178\u76d0(1-[2-[(4-chlorophenyl) methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole)\u3002    \uff082\uff09\u7ed3\u6784\u7279\u70b9\uff1a    econazole\u7684\u5316\u5b66\u7ed3\u6784\u7279\u70b9\u53ef\u4ee5\u770b\u4f5c\u4e3a\u4e59\u9187\u7684\u53d6\u4ee3\u7269\uff0c\u5176\u4e2d\u7f9f\u57fa\u4e3a\u6c2f\u82ef\u7532\u919a\uff0cC-1\u88ab\u4e8c\u6c2f\u82ef\u57fa\u53d6\u4ee3\uff0cC-2\u901a\u8fc7N\u4e0e\u54aa\u5511\u57fa\u8054\u7ed3\uff0c\u56e0\u800cC-1\u662f\u624b\u6027\u78b3\uff0c\u836f\u7269\u5e94\u5177\u6709\u65cb\u5149\u6027\uff0c\u4e34\u5e8a\u4f7f\u7528\u6d88\u65cb\u4f53\u3002    \uff083\uff09\u5408\u6210\u8def\u7ebf\uff1a<\/p>\n<\/p>\n

    \uff084\uff09\u4f5c\u7528\u673a\u5236\uff1a    \u76ca\u5eb7\u5511\u7b49\u5511\u7c7b\u6297\u771f\u83cc\u836f\u7269\u5c5e\u4e8e\u7f8a\u6bdb\u753e\u918714\u03b1-\u53bb\u7532\u57fa\u5316\u9176\uff08Lanosterol 14\u03b1-demethylase\uff09\u6291\u5236\u5242\u3002\u7f8a\u6bdb\u753e\u918714\u03b1-\u53bb\u7532\u57fa\u5316\u9176\u662f\u771f\u83cc\u5fae\u7c92\u4f53\u7ec6\u80de\u8272\u7d20P450\u86cb\u767d\u8d85\u5bb6\u65cf\u4e2d\u7684\u4e00\u4e2a\u6210\u5458\u3002\u8be5\u9176\u662f\u9ea6\u89d2\u753e\u9187(Ergosterol)\u751f\u7269\u5408\u6210\u8fc7\u7a0b\u4e2d\u91cd\u8981\u7684\u4e2d\u95f4\u5408\u6210\u9176\u3002\u5728\u5176\u50ac\u5316\u4e0b\uff0c\u5e95\u7269\u7f8a\u6bdb\u753e\u9187\uff08Lanosterol\uff09\u8f6c\u5316\u4e3a14\u03b1-\u53bb\u7532\u57fa\u7f8a\u6bdb\u753e\u9187\u3002\u6c2e\u5511\u7c7b\u836f\u7269\u5bf9\u6b64\u9176\u6709\u8f83\u5f3a\u7684\u4eb2\u548c\u6027\uff0c\u80fd\u6291\u5236\u5176\u50ac\u5316\u6d3b\u6027\uff0c\u4f7f\u7f8a\u6bdb\u753e\u9187\u5728\u771f\u83cc\u7ec6\u80de\u5185\u84c4\u79ef\uff0c\u5e76\u9020\u6210\u9ea6\u89d2\u753e\u9187\u7f3a\u4e4f\uff0c\u8d77\u5230\u6291\u5236\u771f\u83cc\u7684\u4f5c\u7528\u3002\u9ea6\u89d2\u753e\u9187\u662f\u771f\u83cc\u7ec6\u80de\u819c\u7684\u91cd\u8981\u7ec4\u6210\u6210\u5206,\u5728\u771f\u83cc\u751f\u6d3b\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002    \uff08\u4e8c\uff09\u6c1f\u5eb7\u5511    \uff081\uff09\u7ed3\u6784\u548c\u547d\u540d\uff1a<\/p>\n<\/p>\n

    \u5316\u5b66\u540d\u4e3a-(2,4-\u4e8c\u6c1f\u82ef\u57fa)–(1H-1,2,4-\u4e09\u6c2e\u5511-1-\u57fa\u7532\u57fa)-1H-1,2,4-\u4e09\u6c2e\u5511-1-\u57fa\u4e59\u9187(-(2,4-difluorophenyl)–(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol)\u3002    \uff082\uff09\u4e34\u5e8a\u7528\u9014\uff1a    \u6c1f\u5eb7\u5511\u5bf9\u65b0\u578b\u9690\u7403\u83cc\u3001\u767d\u8272\u5ff5\u73e0\u83cc\u53ca\u5176\u4ed6\u5ff5\u73e0\u83cc\u3001\u9ec4\u66f2\u83cc\u3001\u70df\u66f2\u83cc\u3001\u76ae\u708e\u82bd\u751f\u83cc\u3001\u7c97\u7403\u5b62\u5b50\u83cc\u3001\u835a\u819c\u7ec4\u7ec7\u80de\u6d46\u83cc\u7b49\u6709\u6297\u83cc\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u6c1f\u5eb7\u5511\u53ef\u4ee5\u900f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u66f4\u9002\u5b9c\u4e8e\u6cbb\u7597\u8111\u5185\u611f\u67d3\u6027\u75be\u75c5\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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