\u539f\u6587\u89e3\u8bfb\uff1a\u300a\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u80f0\u817a\u764c\u8bca\u7597\u6307\u5357 2024\u300b\uff08\u4e00\uff09\u524d\u8a00 \u8bca\u65ad<\/p>\n
3. \u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219<\/p>\n<\/p>\n
3.1 \u53ef\u5207\u9664\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219\uff1a\u4e0d\u540c\u4f53\u80fd\u72b6\u6001\u7684\u6cbb\u7597\u63a8\u8350<\/p>\n
\u4f53\u80fd\u72b6\u6001\u826f\u597d\uff0c\u53ef\u8010\u53d7\u624b\u672f\u6cbb\u7597\u7684\u60a3\u8005\uff1a<\/p>\n
I\u7ea7\u63a8\u8350\uff1a1.\u6839\u6cbb\u6027\u624b\u672f\uff1b2.\u672f\u540e\u8f85\u52a9\u5316\u7597\u3002<\/p>\n
II\u7ea7\u63a8\u8350\uff1a1.\u65b0\u8f85\u52a9\u6cbb\u7597\uff1b2.\u8f85\u52a9\u653e\u7597\u3002<\/p>\n
III\u7ea7\u63a8\u8350\uff1a 1.\u6839\u6cbb\u6027\u653e\u7597\u3002<\/p>\n
\u4f53\u80fd\u72b6\u6001\u8f83\u5dee\uff0c\u4e0d\u80fd\u8010\u53d7\u624b\u672f\u6cbb\u7597\u7684\u60a3\u8005\uff1a \t<\/p>\n
I\u7ea7\u63a8\u8350\uff1a1.\u7a7f\u523a\u6d3b\u68c0\u660e\u786e\u75c5\u7406\uff1b 2.\u665a\u671f\u59d1\u606f\u5316\u7597\uff1b3.\u6700\u4f73\u652f\u6301\u6cbb\u7597\u3002<\/p>\n
II\u7ea7\u63a8\u8350\uff1a\u51cf\u75c7\u653e\u7597 \u3002<\/p>\n
III\u7ea7\u63a8\u8350\uff1a1.\u6839\u6cbb\u6027\u653e\u7597\uff1b2.\u4ecb\u5165\u6cbb\u7597\u3002<\/p>\n
\u6ce8\u91ca<\/p>\n
a \u53ef\u5207\u9664\u80f0\u817a\u764c\u5b9a\u4e49\uff1a\u2460\u80bf\u7624\u672a\u63a5\u89e6\u95e8\u9759\u8109-\u80a0\u7cfb\u819c\u4e0a\u9759\u8109\uff0c\u6216\u63a5\u89e6\u95e8\u9759\u8109-\u80a0\u7cfb\u819c\u4e0a\u9759\u8109\u2264180\u00b0\u4e14\u9759\u8109\u8f6e\u5ed3\u6b63\u5e38\u3002\u2461\u80bf\u7624\u672a\u63a5\u89e6\u52a8\u8109(\u8179\u8154\u5e72\u3001\u80a0\u7cfb\u819c\u4e0a\u52a8\u8109\u6216\u809d\u603b\u52a8\u8109)\u3002<\/p>\n
b \u624b\u672f\u76ee\u7684\u662f\u5b9e\u65bd\u6839\u6cbb\u6027\u5207\u9664(R0)\u30101\u3011\u3002\u5207\u7f18\u7684\u76f8\u5173\u5b9a\u4e49\u8be6\u89c1\u201c2.1.2\u80f0\u817a\u764c\u75c5\u7406\u5b66\u8bca\u65ad\u201d\u3002\u6839\u636e\u7efc\u5408\u8bca\u6cbb\u7684\u539f\u5219\uff0c\u672f\u524d\u5e94\u8be5\u8fdb\u884cMDT\u8ba8\u8bba\uff0c\u660e\u786e\u80bf\u7624\u662f\u5426\u6709\u8fdc\u5904\u8f6c\u79fb\u548c\u5408\u5e76\u75c7(\u57fa\u7ebf\u8bc4\u4f30)\uff0c\u5145\u5206\u8bc4\u4f30 R0\u5207\u9664\u7684\u53ef\u80fd\u6027\u3002<\/p>\n
c \u8be6\u89c1\u201c3.1.2\u53ef\u5207\u9664\u80f0\u817a\u764c\u8f85\u52a9\u5316\u7597\u201d\uff1b\u53ef\u5207\u9664\u80f0\u817a\u764c\u8f85\u52a9\u5316\u7597\u65b9\u6848\u8be6\u89c1\u9644\u5f554\u3002<\/p>\n
d \u5bf9\u4e8e\u53ef\u5207\u9664\u80f0\u817a\u764c\uff0c\u65b0\u8f85\u52a9\u6cbb\u7597\u4e0d\u5e38\u89c4\u63a8\u8350\uff0c\u4ec5\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u63a8\u8350\u3002\u4f46\u5bf9\u4e8e\u5177\u6709\u9ad8\u5371\u56e0\u7d20(CA19-9\u663e\u8457\u5347\u9ad8\u3001\u539f\u53d1\u80bf\u7624\u5de8\u5927\u3001\u533a\u57df\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u660e\u786e\u3001\u4f53\u91cd\u660e\u663e\u964d\u4f4e\u548c\u91cd\u5ea6\u75bc\u75db)\u7684\u60a3\u8005\u53ef\u8003\u8651\u884c\u65b0\u8f85\u52a9\u6cbb\u7597\u3002\u6cbb\u7597\u524d\u9700\u660e\u786e\u7ec6\u80de\u5b66\u6216\u75c5\u7406\u5b66\u8bca\u65ad\u30022023\u5e74ASCO\u5e74\u4f1a\u62a5\u9053\u7684 NORPACT-1\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0c\u5bf9\u4e8e\u53ef\u5207\u9664\u80f0\u5934\u764c\u60a3\u8005\u4f7f\u7528FOLFIRINOX\u65b9\u6848\u65b0\u8f85\u52a9\u5316\u7597\u4e0e\u76f4\u63a5\u624b\u672f\u76f8\u6bd4\uff0c\u672a\u663e\u793a\u51fa\u751f\u5b58\u83b7\u76ca(23.0\u4e2a\u6708vs.34.4\u4e2a\u6708\uff0cP=0.058)[2)\u3002PREOPANC\u4e34\u5e8a\u7814\u7a76\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c\u663e\u793a\uff0c\u4ee5\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\u7684\u65b0\u8f85\u52a9\u653e\u5316\u7597\u540e\u884c\u624b\u672f\u5207\u9664\u60a3\u8005\u76845\u5e74OS\u7387\u663e\u8457\u4f18\u4e8e\u76f4\u63a5\u624b\u672f\u540e\u8f85\u52a9\u5316\u7597\u7684\u60a3\u8005(20.5%vs.6.5%\uff0cP=0.025)\u3002\u4f46\u65b0\u8f85\u52a9\u6cbb\u7597\u7ec4\u603bmOS \u4ec5\u5ef6\u957f1.4\u4e2a\u6708(15.7\u4e2a\u6708vs.14.3\u4e2a\u6708)[3]\u30022023\u5e74ESMO\u5e74\u4f1a\u62a5\u9053\u7684PREOPANC-2 \u671f\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0cFOLFIRINOX\u65b0\u8f85\u52a9\u5316\u7597\u4e0e\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\u7684\u65b0\u8f85\u52a9\u653e\u5316\u7597\u4e24\u7ec4\u7684\u624b\u672f\u5207\u9664\u7387(77% vs.75%\uff0cP=0.69)\u548c mOS(21.9\u4e2a\u6708vs.21.3\u4e2a\u6708\uff0cP=0.28)\u5dee\u5f02\u5747\u65e0\u7edf\u8ba1\u5b66\u610f\u4e494)\u3002\u9664\u4e0a\u8ff0\u7814\u7a76\u5916\uff0c\u53ef\u5207\u9664\u80f0\u817a\u764c\u65b0\u8f85\u52a9\u6cbb\u7597\u5c1a\u6709\u591a\u9879\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4f46\u7ed3\u8bba\u4e0d\u4e00\u81f4\u3002\u65b0\u8f85\u52a9\u6cbb\u7597\u5177\u6709\u964d\u4f4e\u80bf\u7624\u5206\u671f\u548c\u7b5b\u9009\u80bf\u7624\u751f\u7269\u5b66\u884c\u4e3a\u7684\u4f5c\u7528\uff0c\u4f46\u5728\u80f0\u817a\u764c\u4e2d\u4ecd\u7f3a\u4e4f\u4e00\u81f4\u6027\u7684\u9ad8\u7ea7\u522b\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\uff0c\u56e0\u6b64\u76ee\u524d\u5c1a\u65e0\u660e\u786e\u63a8\u8350\u7684\u6cbb\u7597\u65b9\u6848\u548c\u6a21\u5f0f(\u901a\u5e38\u5efa\u8bae\u4f7f\u7528\u5ba2\u89c2\u7f13\u89e3\u7387\u8f83\u9ad8\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u9644\u5f555\u4e3a\u80f0\u817a\u764c\u65b0\u8f85\u52a9\u6cbb\u7597\u76f8\u5173\u7814\u7a76\u4e2d\u4f7f\u7528\u7684\u65b9\u6848)\uff0c\u5efa\u8bae\u5f00\u5c55\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n
e \u672f\u540e\u8f85\u52a9\u653e\u7597\u5b58\u5728\u4e89\u8bae[58)\uff0c\u5c1a\u7f3a\u4e4f\u9ad8\u7ea7\u522b\u7684\u5faa\u8bc1\u533b\u5b66\u4f9d\u636e\uff0c\u5efa\u8bae\u79ef\u6781\u53c2\u4e0e\u4e34\u5e8a\u7814\u7a76\u3002\u4e0e\u5355\u72ec\u5316\u7597\u76f8\u6bd4\uff0c\u5bf9R1\u5207\u9664\u4f34\u4f53\u80fd\u72b6\u6001\u826f\u597d\u7684\u60a3\u8005\uff0c\u91c7\u7528\u8f85\u52a9\u653e\u7597\u53ef\u80fd\u6539\u5584\u9884\u540e\uff0c\u964d\u4f4e\u80bf\u7624\u5c40\u90e8\u590d\u53d1\u7387\u3002<\/p>\n
f \u6839\u6cbb\u6027\u653e\u7597\u662f\u91c7\u7528\u7cbe\u51c6\u653e\u7597\u6280\u672f\uff0c\u901a\u8fc7\u63d0\u9ad8\u5242\u91cf\uff0c\u8fdb\u800c\u5b9e\u65bd\u4ee5\u6839\u6cbb\u6027\u6cbb\u7597\u4e3a\u76ee\u7684\u7684\u653e\u7597\u6a21\u5f0f\u3002\u63a8\u8350\u5728\u6709\u7ecf\u9a8c\u7684\u4e2d\u5fc3\uff0c\u91c7\u7528\u8c03\u5f3a\u653e\u5c04\u6cbb\u7597(IMRT)\u6216\u7acb\u4f53\u5b9a\u5411\u4f53\u90e8\u653e\u5c04\u6cbb\u7597(SBRT)\u6280\u672f\uff0c\u5242\u91cf\u6a21\u5f0f\u6839\u636e\u8bbe\u5907\u6280\u672f\u548c\u75c5\u7076\u4e0e\u80c3\u80a0\u7684\u5173\u7cfb\uff0c\u9009\u62e9\u9ad8\u5242\u91cf\u5c11\u5206\u6b21\u540c\u6b65\u52a0\u91cf\u6cbb\u7597\u6a21\u5f0f\uff0c\u63a8\u8350\u9ad8\u5242\u91cf\u533a\u751f\u7269\u7b49\u6548\u5242\u91cf(BED)\u8fbe\u5230100Gy\u5de6\u53f3[9-12]<\/p>\n
g \u5bf9\u4e8e\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u9650\u6027\u80f0\u817a\u764c\uff0c\u56e0\u533b\u5b66\u3001\u60a3\u8005\u81ea\u8eab\u610f\u613f\u6216\u9ad8\u9f84\u7b49\u539f\u56e0\uff0c\u4e0d\u80fd\u8010\u53d7\u6216\u4e0d\u9002\u5408\u624b\u672f\u5207\u9664\u3002 <\/p>\n
h \u665a\u671f\u59d1\u606f\u5316\u7597\u8be6\u89c1\u201c3.4\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219\u201d\u3002<\/p>\n
i \u6700\u4f73\u652f\u6301\u6cbb\u7597\u5305\u62ec\u8425\u517b\u652f\u6301\u3001\u89e3\u9664\u9ec4\u75b8\u3001\u6b62\u75db\u3001\u6cbb\u7597\u80bf\u7624\u76f8\u5173\u6027\u8840\u6813\u4ee5\u53ca\u6cbb\u7597\u624b\u672f\u548c\u653e\u5316\u7597\u5f15\u8d77\u7684\u5404\u79cd\u5e76\u53d1\u75c7\u548c\u4e0d\u826f\u53cd\u5e94(\u8be6\u89c1\u201c5.1\u6700\u4f73\u652f\u6301\u6cbb\u7597\u201d)\u3002 <\/p>\n
j \u8be6\u89c1\u201c3.4\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219\u201d\u3002<\/p>\n
3.1.1 \u53ef\u5207\u9664\u80f0\u817a\u764c\u5916\u58f3\u624b\u672f<\/p>\n<\/p>\n
[\u6ce8\u91ca]<\/p>\n
a \u6269\u5927\u533a\u57df\u6dcb\u5df4\u7ed3\u6e05\u626b\u4e0d\u80fd\u6539\u5584\u60a3\u8005\u7684\u9884\u540e\uff0c\u4e0d\u5e38\u89c4\u63a8\u8350[1.3)<\/p>\n
b \u5fae\u521b\u80f0\u5341\u4e8c\u6307\u80a0\u5207\u9664\u672f\u5305\u62ec\u8179\u8154\u955c\u624b\u672f\u548c\u673a\u5668\u4eba\u624b\u672f\u3002\u4e00\u9879\u524d\u77bb\u968f\u673a\u5bf9\u7167\u7814\u7a76\u663e\u793a\uff0c\u5728\u80f0\u817a\u75be\u75c5<\/p>\n
\u4e13\u4e1a\u673a\u6784\u7531\u7ecf\u9a8c\u4e30\u5bcc\u7684\u5916\u79d1\u533b\u751f\u5b9e\u65bd\u7684\u8179\u8154\u955c\u80f0\u5341\u4e8c\u6307\u80a0\u5207\u9664\u672f\uff0c\u5176\u672f\u540e\u2162~IV\u7ea7\u5e76\u53d1\u75c7\u4e0e\u5f00\u8179\u624b\u672f\u76f8\u6bd4\u5dee\u5f02\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49(17.0%vs.23.0%\uff0cP=0.29)(4)\u3002\u4e00\u9879\u6d89\u53ca\u80f0\u817a\u764c\u53ca\u58f6\u8179\u5468\u56f4\u764c\u524d\u77bb\u968f\u673a\u5bf9\u7167\u7814\u7a76\u663e\u793a\uff0c\u884c\u8179\u8154\u955c\u80f0\u5341\u4e8c\u6307\u80a0\u5207\u9664\u672f\u7684\u80f0\u817a\u764c\u4e9a\u7ec4\u60a3\u8005\u76843\u5e74\u751f\u5b58\u7387\u4e0e\u5f00\u8179\u80f0\u5341\u4e8c\u6307\u80a0\u5207\u9664\u672f\u76f8\u6bd4\u5dee\u5f02\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49(51.8%vs.48.9%\uff0cP=0.87)[5]\u3002\u5fae\u521b\u80f0\u5341\u4e8c\u6307\u80a0\u5207\u9664\u672f\u4ec5\u63a8\u8350\u5728\u4e00\u5b9a\u89c4\u6a21\u80f0\u817a\u75be\u75c5\u4e13\u4e1a\u673a\u6784\u7531\u7ecf\u9a8c\u4e30\u5bcc\u7684\u5916\u79d1\u533b\u751f\u5b9e\u65bd\uff0c\u5173\u4e8e\u5176\u624b\u672f\u9002\u5e94\u8bc1\u53ca\u66f4\u5927\u6837\u672c\u7684\u8fdc\u671f\u9884\u540e\u6570\u636e\u4ecd\u9700\u8fdb\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n
c \u5fae\u521b\u80f0\u4f53\u5c3e\u813e\u5207\u9664\u672f\u5305\u62ec\u8179\u8154\u955c\u624b\u672f\u548c\u673a\u5668\u4eba\u624b\u672f\u3002\u9488\u5bf9\u80f0\u4f53\u5c3e\u764c\u7684\u5fae\u521b\u80f0\u4f53\u5c3e\u813e\u5207\u9664\u662f\u5b89\u5168\u53ef\u884c\u7684\u3002LEOPARD\u7814\u7a76\u663e\u793a\u5fae\u521b\u80f0\u4f53\u5c3e\u813e\u5207\u9664\u672f\u53ef\u7f29\u77ed\u672f\u540e\u6062\u590d\u65f6\u95f4\uff0c\u5e76\u4e0e\u964d\u4f4e\u80c3\u6392\u7a7a\u5ef6\u8fdf\u548c\u66f4\u597d\u7684\u751f\u6d3b\u8d28\u91cf\u76f8\u51736)\u3002DIPLOMA\u7814\u7a76\u663e\u793a\u9488\u5bf9\u53ef\u5207\u9664\u80f0\u4f53\u5c3e\u764c\u60a3\u8005\uff0c\u5728\u6839\u6cbb\u6027\u5207\u9664\u7387\u53ca\u8fdc\u671f\u751f\u5b58\u65b9\u9762\uff0c\u5fae\u521b\u80f0\u4f53\u5c3e\u813e\u5207\u9664\u672f\u4e0d\u52a3\u4e8e\u5f00\u8179\u624b\u672f[7]\u3002<\/p>\n
d \u4f4d\u4e8e\u80f0\u817a\u9888\u90e8\u7684\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u7684\u624b\u672f\u65b9\u5f0f\u9700\u672f\u4e2d\u63a2\u67e5\u660e\u786e\u3002\u6839\u636e\u80bf\u7624\u8303\u56f4\u548c\u5927\u5c0f\uff0c\u624b\u672f\u65b9\u5f0f\u5305\u62ec\u80f0\u5341\u4e8c\u6307\u80a0\u5207\u9664\u672f\uff0c\u80f0\u9888\u4f53\u5c3e\u813e\u5207\u9664\u672f\u6216\u5168\u80f0\u5207\u9664\u672f\u3002\u80f0\u817a\u9888\u90e8\u764c\u5e38\u7d2f\u53ca\u95e8\u9759\u8109-\u80a0\u7cfb\u819c\u4e0a\u9759\u8109\uff0c\u9700\u8054\u5408\u9759\u8109\u5207\u9664\u91cd\u5efa[8]\u3002<\/p>\n
3.1.2 \u53ef\u5207\u9664\u80f0\u817a\u764c\u8f85\u52a9\u5316\u7597<\/p>\n<\/p>\n
[\u6ce8\u91ca]<\/p>\n
a \u4e0e\u5355\u7eaf\u624b\u672f\u76f8\u6bd4\uff0c\u672f\u540e\u8f85\u52a9\u5316\u7597\u5177\u6709\u660e\u786e\u7684\u7597\u6548\uff0c\u53ef\u4ee5\u9632\u6b62\u6216\u5ef6\u7f13\u80bf\u7624\u590d\u53d1\uff0c\u63d0\u9ad8\u672f\u540e\u957f\u671f\u751f\u5b58\u7387\u3002\u56e0\u6b64\uff0c\u79ef\u6781\u63a8\u8350\u672f\u540e\u5b9e\u65bd\u8f85\u52a9\u5316\u7597\uff0c\u4e14\u8f85\u52a9\u6cbb\u7597\u5e94\u5728\u672f\u540e12 \u5468\u5185\u5f00\u59cb\u3002<\/p>\n
b \u5bf9\u4e8e\u4f53\u80fd\u72b6\u6001\u826f\u597d\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u8003\u8651\u8054\u5408\u5316\u7597\u65b9\u6848(\u8be6\u89c1\u9644\u5f554)\u3002\u6b64\u5904\u4f53\u80fd\u72b6\u6001\u826f\u597d\u6807\u51c6\u540c\u524d(\u8be6\u89c1\u201c2.1\u80f0\u817a\u764c\u7684\u8bca\u7597\u603b\u5219\u201d)\u3002<\/p>\n
c 2017\u5e74\u53d1\u8868\u5728\u300a\u67f3\u53f6\u5200\u300b\u7684ESPAC-4\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u5409\u897f\u4ed6\u6ee8\u8054\u5408\u5361\u57f9\u4ed6\u6ee8(GX)\u5bf9\u6bd4\u5409\u897f\u4ed6\u6ee8(G\u8f85\u52a9\u6cbb\u7597\u80f0\u817a\u764c\u6839\u6cbb\u672f\u540e\u60a3\u8005\uff0c\u5bf9\u4e8e\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9OS\uff0cGX\u663e\u8457\u4f18\u4e8eG(28.0\u4e2a\u6708vs.25.5\u4e2a\u6708\uff0c P=0.032),\u4e14GX\u7ec4\u76845\u5e74\u751f\u5b58\u7387\u8fbe\u5230 28.8%\u3002<\/p>\n
d 2018\u5e74\u53d1\u8868\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u7684PRODIGE 24\/CCTGPA.6\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0cmFOLFIRINOX\u5bf9\u6bd4\u5409\u897f\u4ed6\u6ee8\u5355\u836f\u6cbb\u7597\u80f0\u817a\u764c\u6839\u6cbb\u672f\u60a3\u8005\u3002mFOLFIRINOX\u7ec4\u7684DFS\u957f\u4e8e\u5409\u897f\u4ed6\u6ee8\u7ec4(21.6\u4e2a\u6708vs.12.8\u4e2a\u6708\uff0cP<0.0001),3\u5e74\u65e0\u75c5\u751f\u5b58\u7387\u66f4\u9ad8(39.7% vs.21.4% )\u3002mFOLFIRINOX\u7ec4\u7684\u4e2d\u4f4dOS\u66f4\u957f(54.4\u4e2a\u6708vs.35.0\u4e2a\u6708\uff0cP=0.003)\u3002<\/p>\n
e \u5409\u897f\u4ed6\u6ee8\u8054\u5408\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187(AG\u65b9\u6848)\u5bf9\u6bd4\u5409\u897f\u4ed6\u6ee8\u5355\u836f\u7528\u4e8e\u80f0\u817a\u764c\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u7684\u968f\u673a\u5bf9\u7167\u2162\u671fAPACT\u7814\u7a76\uff0c\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u72ec\u7acb\u5f71\u50cf\u5b66\u8bc4\u4f30\u7684\u65e0\u75c5\u751f\u5b58\u671f(DFS)\u672a\u53d6\u5f97\u9633\u6027\u7ed3\u679c(19.4\u4e2a\u6708vs.18.8\u4e2a\u6708\uff0cP=0.1824)\u30022021\u5e74ESMO\u5e74\u4f1a\u8fdb\u4e00\u6b65\u62a5\u544a\u4e865\u5e74\u751f\u5b58\u671f(OS)\u968f\u8bbf\u7ed3\u679c\uff0c\u63d0\u793aAG\u65b9\u6848\u53ef\u663e\u8457\u5ef6\u957fOS(41.8\u4e2a\u6708vs.37.7\u4e2a\u6708\uff0cP=0.0091)\u3002\u56e0\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u9634\u6027\u7ed3\u679c\uff0c\u6307\u5357\u7ed9\u4e88\u2161\u7ea7\u63a8\u8350\u3002<\/p>\n
3.1.3 \u53ef\u5207\u9664\u80f0\u817a\u764c\u8f85\u52a9\u653e\u7597<\/p>\n<\/p>\n
[\u6ce8\u91ca]<\/p>\n
a \u8f85\u52a9\u653e\u7597\u7684\u6cbb\u7597\u4f53\u79ef\u5e94\u57fa\u4e8e\u624b\u672f\u524dCT\u626b\u63cf\u7ed3\u679c\u6216\u624b\u672f\u7f6e\u5165\u7684\u94f6\u5939\u6765\u786e\u5b9a\u3002\u6807\u51c6\u653e\u7597\u4f53\u79efCTV\u5e94\u5305\u62ec\u539f\u53d1\u80bf\u7624\u5e8a\u548c\u533a\u57df\u9ad8\u5371\u6dcb\u5df4\u7ed3\u533a\u3002\u5bf9\u6b8b\u7aef\u9633\u6027\u90e8\u4f4d\u5efa\u8bae\u9002\u5ea6\u63d0\u9ad8\u5242\u91cf\u3002<\/p>\n
b \u968f\u673a\u5bf9\u7167\u7814\u7a76\u663e\u793a\uff0c\u653e\u5316\u7597\u5728\u6b27\u7f8e\u5730\u533a\u7684\u7814\u7a76\u7ed3\u679c\u6709\u5dee\u5f02\uff0c\u56fd\u5185\u7814\u7a76\u8bc1\u636e\u7ea7\u522b\u76f8\u5bf9\u8f83\u4f4e\uff0c\u56e0\u6b64\u7f3a\u4e4f\u8db3\u591f\u7684\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\uff0c\u5efa\u8bae\u5f00\u5c55\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n
c \u653e\u7597\u540c\u6b65\u7cfb\u7edf\u7684\u6cbb\u7597\u65b9\u5f0f\u53c2\u80033.3\u5c40\u90e8\u8fdb\u5c55\u671f\u80f0\u817a\u764c\uff0c\u8be6\u89c1\u9644\u5f556\u3002<\/p>\n
3.2 \u4e34\u754c\u53ef\u5207\u9664\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219<\/p>\n<\/p>\n
[\u6ce8\u91ca]<\/p>\n
a \u4e34\u754c\u53ef\u5207\u9664\u80f0\u817a\u764c\u5b9a\u4e49:\u2460\u80bf\u7624\u63a5\u89e6\u95e8\u9759\u8109-\u80a0\u7cfb\u819c\u4e0a\u9759\u8109>180\u00b0\uff0c\u6216\u63a5\u89e6\u2264180\u00b0\u5408\u5e76\u9759\u8109\u8f6e\u5ed3\u4e0d\u89c4\u5219\u6216\u9759\u8109\u8840\u6813\uff0c\u4f46\u53ef\u5b8c\u6574\u5207\u9664\u5e76\u5b89\u5168\u91cd\u5efa;\u80bf\u7624\u63a5\u89e6\u4e0b\u8154\u9759\u8109\u3002\u2461(\u80f0\u5934\/\u94a9\u7a81\u80bf\u7624)\u80bf\u7624\u63a5\u89e6\u809d\u603b\u52a8\u8109\uff0c\u4f46\u672a\u7d2f\u53ca\u8179\u8154\u5e72\u52a8\u8109\u6216\u5de6\u53f3\u809d\u52a8\u8109\u8d77\u59cb\u90e8\uff0c\u80fd\u591f\u5b8c\u6574\u5207\u9664\u5e76\u5b89\u5168\u91cd\u5efa;\u80bf\u7624\u63a5\u89e6\u80a0\u7cfb\u819c\u4e0a\u52a8\u8109\u2264180\u00b0;\u80bf\u7624\u63a5\u89e6\u53d8\u5f02\u7684\u52a8\u8109(\u5982\u526f\u809d\u53f3\u52a8\u8109\uff0c\u66ff\u4ee3\u809d\u53f3\u52a8\u8109\u3001\u66ff\u4ee3\u809d\u603b\u52a8\u8109\u7b49)\u3002(\u80f0\u4f53\u5c3e\u80bf\u7624)\u80bf\u7624\u63a5\u89e6\u80a0\u7cfb\u819c\u4e0a\u52a8\u8109\u2264180\u00b0;\u80bf\u7624\u63a5\u89e6\u8179\u8154\u5e72\u52a8\u8109\u2264180\u00b0\u3002<\/p>\n
b \u5bf9\u4e8e\u4e34\u754c\u53ef\u5207\u9664\u80f0\u817a\u764c\u7684\u8bca\u7597\uff0c\u5927\u578b\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5f00\u5c55\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n
c \u6700\u4f73\u652f\u6301\u6cbb\u7597\u5e94\u8d2f\u7a7f\u80f0\u817a\u764c\u6cbb\u7597\u7684\u6574\u4e2a\u8fc7\u7a0b\u4e2d\u3002\u5bf9\u4f53\u80fd\u72b6\u6001\u5dee\uff0c\u65e0\u6cd5\u8010\u53d7\u624b\u672f\u3001\u653e\u7597\u548c\u5316\u7597\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u4ec5\u884c\u6700\u4f73\u652f\u6301\u6cbb\u7597(\u8be6\u89c1\u201c5.1\u6700\u4f73\u652f\u6301\u6cbb\u7597\u201d)\u3002<\/p>\n
d \u5bf9\u4e8e\u80f0\u5934\u90e8\u4e34\u754c\u53ef\u5207\u9664\u80f0\u817a\u764c\uff0c\u60a3\u8005\u53ef\u80fd\u5b58\u5728\u9ec4\u75b8\uff0c\u5728\u63a5\u53d7\u65b0\u8f85\u52a9\u6cbb\u7597\u524d\uff0c\u5efa\u8bae\u884c\u4ecb\u5165\u6cbb\u7597(\u80c6\u7ba1\u5185\u652f\u67b6\uff0c\u9f3b\u80c6\u7ba1\u5f15\u6d41\u3001\u7ecf\u76ae\u809d\u7a7f\u523a\u80c6\u9053\/\u80c6\u56ca\u5f15\u6d41\u7b49)\u89e3\u9664\u9ec4\u75b8\u3002<\/p>\n
e \u4e34\u754c\u53ef\u5207\u9664\u80f0\u817a\u764c\u884c\u65b0\u8f85\u52a9\u5316\u7597\u3001\u653e\u5316\u7597\u80fd\u63d0\u9ad8R0\u5207\u9664\u7387\uff0c\u5e76\u53ef\u6539\u5584\u60a3\u8005\u751f\u5b58[12]\u3002\u63a8\u8350\u5bf9\u6240\u6709\u4f53\u80fd\u72b6\u51b5\u826f\u597d\u7684\u4e34\u754c\u53ef\u5207\u9664\u80f0\u817a\u764c\u60a3\u8005\uff0c\u5f00\u5c55\u65b0\u8f85\u52a9\u6cbb\u7597(\u9644\u5f555)\u6216\u53c2\u52a0\u4e34\u5e8a\u7814\u7a76\u3002\u901a\u8fc7\u65b0\u8f85\u52a9\u6cbb\u7597\u4ecd\u4e0d\u80fd\u624b\u672f\u5207\u9664\u6216\u4e0d\u80fd\u8010\u53d7\u624b\u672f\u7684\u60a3\u8005\uff0c\u5373\u91c7\u7528\u665a\u671f\u80f0\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848(\u9644\u5f559)\u3002<\/p>\n
f PREOPANC\u548cPREOPANC-2\u8fd9\u4e24\u9879\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u63d0\u793a\u4e34\u754c\u53ef\u5207\u9664\u80f0\u817a\u764c\u53ef\u4ece\u65b0\u8f85\u52a9\u653e\u7597\u65b9\u6848\u83b7\u76ca\u201c12)\u3002\u65b0\u8f85\u52a9\u653e\u5316\u7597\u8054\u5408\u65b9\u6848\u53ef\u91c7\u7528\u6c1f\u5c3f\u5627\u5576\u7c7b[3]\u6216GEM\u65b9\u6848\u653e\u75974]\uff0c\u6216\u8bf1\u5bfc\u5316\u7597\u6709\u6548\u540e\u91c7\u7528\u542b5-FU\u6216\u542bGEM\u65b9\u6848\u7684\u540c\u6b65\u653e\u5316\u7597\u300c\u201d\u3002\u6839\u636ePREOPANC\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff0c\u65b0\u8f85\u52a9\u653e\u5316\u7597\u53ef\u9996\u9009\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\u7684\u653e\u5316\u7597\u65b9\u6848(\u8be6\u89c1\u9644\u5f555)1\u3002\u53e6\u5916\uff0cJASPACO5\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff0c\u672f\u524d\u91c7\u7528S-1\u8054\u5408\u540c\u6b65\u653e\u7597\u53ef\u884c\u3001\u6709\u6548\uff0c\u5e76\u4e14\u53ef\u4ee5\u63d0\u9ad8RO\u5207\u9664\u7387\uff0c\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d[6]\u3002<\/p>\n
g \u65b0\u8f85\u52a9\u5316\u7597\u76ee\u524d\u5c1a\u65e0\u6807\u51c6\u65b9\u6848\u548c\u6a21\u5f0f\uff0c\u5efa\u8bae\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\u3002\u65b0\u8f85\u52a9\u5316\u7597\u63a8\u83504~6\u4e2a\u5468\u671f\uff0c\u4e00\u9879\u4f7f\u7528\u5168\u7a0b\u65b0\u8f85\u52a9\u6cbb\u7597(TNT)\u6a21\u5f0f\u7684\u56de\u987e\u6027\u7814\u7a76\u663e\u793a\uff0c\u65b0\u8f85\u52a9\u5316\u7597\u7ef4\u6301\u8d85\u8fc76\u5468\u671f\uff0c\u662f\u672f\u540e\u751f\u5b58\u7387\u6539\u5584\u7684\u9884\u6d4b\u6307\u6807\u4e4b\u4e00[7]\u30022023\u5e74ESMO\u5e74\u4f1a\u62a5\u9053\u7684PREOPANC-2\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0cFOLFIRINOX\u65b0\u8f85\u52a9\u5316\u7597\u4e0e\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\u7684\u65b0\u8f85\u52a9\u653e\u5316\u7597\u7684mOS\u5dee\u5f02\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49(21.9\u4e2a\u6708vs.21.3\u4e2a\u6708\uff0cP=0.28)[2]\u3002\u5efa\u8bae\u65b0\u8f85\u52a9\u5316\u7597\u7684\u5177\u4f53\u5468\u671f\u53ef\u6839\u636e\u5bc6\u5207\u590d\u67e5\u7ed3\u679c\u8fdb\u884c\u8c03\u6574\u3002<\/p>\n
h \u7ecf\u65b0\u8f85\u52a9\u6cbb\u7597\u540e\u884c\u5916\u79d1\u624b\u672f\u7684\u53c2\u8003\u5efa\u8bae:\u2460\u5f71\u50cf\u5b66\u786e\u8ba4\u6ca1\u6709\u8fdc\u5904\u8f6c\u79fb\uff0c\u53ef\u5728\u7efc\u5408\u8bc4\u4ef7\u540e\u4f7f\u7528\u8179\u8154\u955c\u63a2\u67e5\uff0c\u907f\u514d\u59d1\u606f\u6027\u5207\u9664\u624b\u672f\u3002\u2461\u5982\u679cCA19-9\u80fd\u591f\u7a33\u5b9a\u6216\u8005\u4e0b\u964d\uff0c\u5f71\u50cf\u5b66\u68c0\u67e5\u672a\u663e\u793a\u660e\u663e\u8fdb\u5c55\uff0c\u5c31\u53ef\u4ee5\u5b9e\u65bd\u624b\u672f\u63a2\u67e5\u5207\u9664\u3002\u2462\u5982\u65b0\u8f85\u52a9\u6cbb\u7597\u540e\u80bf\u7624\u5c40\u90e8\u8fdb\u5c55\uff0c\u662f\u5426\u624b\u672f\u9700\u7ecf\u591a\u5b66\u79d1\u8ba8\u8bba\u540e\u614e\u91cd\u51b3\u5b9a\u3002\u4f46\u8840\u7ba1\u5468\u56f4\u8f6f\u7ec4\u7ec7\u7684\u8f7b\u5ea6\u589e\u539a\u53ef\u80fd\u4e3a\u7ea4\u7ef4\u5316\uff0c\u975e\u624b\u672f\u63a2\u67e5\u7684\u7981\u5fcc;\u5c24\u5176\u5f53\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u6709\u6539\u5584\u65f6(\u5373\u4f53\u529b\u72b6\u6001\u3001\u75bc\u75db\u3001\u98df\u6b32\u3001\u4f53\u91cd\/\u8425\u517b\u72b6\u51b5\u6539\u5584)\uff0c\u4e0d\u5e94\u653e\u5f03\u624b\u672f\u63a2\u67e5\u3002\u8be6\u89c1\u201c3.1\u53ef\u5207\u9664\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219\u201d\u3002<\/p>\n
i \u8bf1\u5bfc\u6cbb\u75974~6\u4e2a\u5468\u671f\uff0c\u75be\u75c5\u63a7\u5236\u540e\uff0c\u53ef\u884c\u4e0d\u53ef\u9006\u7535\u7a7f\u5b54\u6d88\u878d\u6cbb\u7597(\u8be6\u89c1\u9644\u5f557)\u3002k \u4e0d\u80fd\u8010\u53d7\u6216\u4e0d\u613f\u63a5\u53d7\u5168\u8eab\u5316\u7597\u7684\u60a3\u8005\uff0c\u53ef\u884c\u9009\u62e9\u6027\u52a8\u8109\u704c\u6ce8\u5316\u7597\u30021 \u8be6\u89c1\u201c3.4\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219\u201d\u3002<\/p>\n<\/p>\n
[\u6ce8\u91ca]<\/p>\n
a \u5c40\u90e8\u8fdb\u5c55\u671f\u80f0\u817a\u764c\u5b9a\u4e49:\u2460\u56e0\u80bf\u7624\u4fb5\u72af\u3001\u9759\u8109\u95ed\u585e\u6216\u7d2f\u53ca\u5927\u8303\u56f4\u80a0\u7cfb\u819c\u4e0a\u9759\u8109\u7a7a\u80a0\u5206\u652f\uff0c\u65e0\u6cd5\u5b89\u5168\u91cd\u5efa\u95e8\u9759\u8109-\u80a0\u7cfb\u819c\u4e0a\u9759\u8109\u3002\u2461(\u80f0\u5934\/\u94a9\u7a81\u80bf\u7624)\u80bf\u7624\u63a5\u89e6\u80a0\u7cfb\u819c\u4e0a\u52a8\u8109\u6216\u8179\u8154\u5e72\u52a8\u8109>180\u00b0\u3002(\u80f0\u4f53\u5c3e\u80bf\u7624)\u80bf\u7624\u63a5\u89e6\u80a0\u7cfb\u819c\u4e0a\u52a8\u8109\u6216\u8179\u8154\u5e72\u52a8\u8109>180\u00b0\uff0c\u80bf\u7624\u63a5\u89e6\u8179\u8154\u5e72\u52a8\u8109\u5e76\u6d78\u6da6\u8179\u4e3b\u52a8\u8109\u3002<\/p>\n
b \u5c40\u90e8\u665a\u671f\u80f0\u817a\u764c\u9884\u540e\u5dee\uff0c\u4e14\u7f3a\u4e4f\u5ba2\u89c2\u3001\u6709\u6548\u7387\u9ad8\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u56e0\u6b64\u5efa\u8bae\u53c2\u52a0\u4e34\u5e8a\u7814\u7a76\u3002c\u6700\u4f73\u652f\u6301\u6cbb\u7597\u5e94\u8d2f\u7a7f\u80f0\u817a\u764c\u6cbb\u7597\u7684\u6574\u4e2a\u8fc7\u7a0b\u4e2d(\u8be6\u89c1\u201c5.1\u6700\u4f73\u652f\u6301\u6cbb\u7597\u201d)\u3002d \u665a\u671f\u59d1\u606f\u5316\u7597\u8be6\u89c1\u201c3.4\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219\u201d\u3002e\u8f6c\u5316\u6027\u5316\u7597\u65b9\u6848\u8be6\u89c1\u9644\u5f555\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n
f 2022\u5e74ASCO\u5e74\u4f1a\u4e0aCONKO-007\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u521d\u6b65\u6570\u636e\u663e\u793a\uff0c\u5c40\u90e8\u8fdb\u5c55\u671f\u80f0\u817a\u764c\u63a5\u53d7\u8bf1\u5bfc\u5316\u7597\u5e8f\u8d2f\u540c\u6b65\u653e\u5316\u7597(50.4Gy\/28f\u8054\u5408\u5409\u897f\u4ed6\u6ee8)\uff0c\u8f83\u8bf1\u5bfc\u5316\u7597\u540e\u7ef4\u6301\u5316\u7597\u8005\u53ef\u663e\u8457\u63d0\u9ad8\u624b\u672f\u5207\u9664\u60a3\u8005\u7684RO\u5207\u9664\u7387(69%vs.50%\uff0cP=0.0418)\u548c\u75c5\u7406pCR\u7387(18%vs.2%\uff0cP=0.0043)\u3002\u7ecf\u8f6c\u5316\u540e\u884c\u624b\u672f\u5207\u9664\u60a3\u8005\u7684OS\u663e\u8457\u4f18\u4e8e\u672a\u63a5\u53d7\u624b\u672f\u7684\u60a3\u8005(mOS:19\u4e2a\u6708vs.15\u4e2a\u6708\uff0c5\u5e74OS\u7387:17.5% vs.0; P<0.001)\u300cl]\u3002<\/p>\n
g \u5bf9\u4e8e\u5168\u8eab\u72b6\u51b5\u826f\u597d\u7684\u5c40\u90e8\u665a\u671f\u80f0\u817a\u764c\uff0c\u91c7\u7528\u5e38\u89c4\u5242\u91cf\u653e\u7597\u540c\u6b65\u5316\u7597[2]\u6216\u5e8f\u8d2f\u653e\u5316\u7597[34]\u53ef\u7f13\u89e3\u75c7\u72b6\u548c\u6539\u5584\u60a3\u8005\u751f\u5b58\u671f\u300c5\u3002\u9ad8\u5242\u91cf\u653e\u7597\u8f83\u5e38\u89c4\u5242\u91cf\u653e\u7597\u53ef\u63d0\u9ad8\u5c40\u90e8\u63a7\u5236\u7387\uff0c\u53ef\u5ef6\u957f\u60a3\u8005\u603b\u751f\u5b58\u65f6\u95f4[6\u3002\u653e\u7597\u65b9\u6848\u8be6\u89c1\u9644\u5f556\u3002<\/p>\n
h \u5bf9\u4e8e\u8f6c\u5316\u6cbb\u7597\u6709\u6548\u4e14\u4f53\u80fd\u72b6\u6001\u826f\u597d\u7684\u60a3\u8005\uff0c\u53ef\u53c2\u7167\u201c3.2\u4e34\u754c\u53ef\u5207\u9664\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219\u201d\u3002\u5bf9\u4e8e\u8f6c\u5316\u6cbb\u7597\u540e\uff0c\u4ecd\u4e0d\u80fd\u5207\u9664\u6216\u4f53\u80fd\u72b6\u6001\u8f83\u5dee\u7684\u60a3\u8005\uff0c\u8f6c\u5165\u665a\u671f\u59d1\u606f\u6cbb\u7597\u3002 i \u4ecb\u5165\u6cbb\u7597\u8be6\u89c1\u201c3.2\u4e34\u754c\u53ef\u5207\u9664\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219\u201d\u3002 <\/p>\n
j \u4e2d\u533b\u4e2d\u836f\u6cbb\u7597\u89c1\u9644\u5f55 8\u3002<\/p>\n
k \u8bf1\u5bfc\u6cbb\u7597 4~6\u4e2a\u5468\u671f\uff0c\u75be\u75c5\u63a7\u5236\u540e\uff0c\u53ef\u884c\u4e0d\u53ef\u9006\u7535\u7a7f\u5b54\u6d93\u8096\u878d\u6cbb\u7597(\u8be6\u89c1\u9644\u5f557)\u3002<\/p>\n
l \u4e00\u9879\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0c\u7535\u573a\u7597\u6cd5\u8054\u5408\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\u548c\u5409\u897f\u4ed6\u6ee8\u53ef\u663e\u8457\u5ef6\u957f\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u7684PFS(12.7\u4e2a\u6708)\u548cOS(\u5c1a\u672a\u8fbe\u5230)\uff0c\u2162\u671f\u4e34\u5e8a\u7814\u7a76PANOVA-3\u6b63\u5728\u8fdb\u884c\u4e2d(\u8be6\u89c1\u9644\u5f557)[7]\u3002<\/p>\n
m \u51cf\u75c7\u653e\u7597\u8be6\u89c1\u201c3.4\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219\u201d\u3002<\/p>\n
3.4 \u8f6c\u79fb\u6027\u80f0\u817a\u764c\u6cbb\u7597\u539f\u5219\uff1a<\/p>\n<\/p>\n
[\u6ce8\u91ca]<\/p>\n
a \u8f6c\u79fb\u6027\u80f0\u817a\u764c\u6cbb\u7597\u76ee\u7684\u548c\u539f\u5219:\u2460\u5bf9\u4e8e\u8f6c\u79fb\u6027\u80f0\u817a\u764c\uff0c\u4ee5\u5316\u7597\u4e3a\u57fa\u7840\u7684\u7efc\u5408\u6cbb\u7597\u6709\u5229\u4e8e\u51cf\u8f7b\u75c7\u72b6\u3001\u5ef6\u957f\u751f\u5b58\u671f\u548c\u63d0\u9ad8\u751f\u6d3b\u8d28\u91cf\u3002\u2461\u5bf9\u4e8e\u5be1\u8f6c\u79fb\u80f0\u817a\u764c\uff0c\u4ee5\u5316\u7597\u4e3a\u57fa\u7840\uff0c\u653e\u7597\u5bf9\u75c5\u7076\u9009\u62e9\u6027\u6cbb\u7597\u7684\u7efc\u5408\u6cbb\u7597\u66f4\u6709\u5229\u4e8e\u51cf\u75c7\u3001\u63d0\u9ad8\u5c40\u90e8\u63a7\u5236\u7387\u548c\u5ef6\u957f\u751f\u5b58\u671f.<\/p>\n
b \u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u5e94\u6839\u636e\u60a3\u8005\u4f53\u80fd\u72b6\u6001\u8fdb\u884c\u9009\u62e9\u3002\u5bf9\u4e8e\u4f53\u80fd\u72b6\u6001\u826f\u597d\u7684\u60a3\u8005\uff0c\u53ef\u8003\u8651\u8054\u5408\u65b9\u6848;\u4f53\u80fd\u72b6\u6001\u8f83\u5dee\u7684\u60a3\u8005\u9009\u62e9\u5355\u836f\u5316\u7597\u6216\u6700\u4f73\u652f\u6301\u6cbb\u7597(\u8be6\u89c1\u9644\u5f559\u548c\u201c5.1\u6700\u4f73\u652f\u6301\u6cbb\u7597\u201d)\u3002\u80f0\u817a\u764c\u7684\u603b\u4f53\u6cbb\u7597\u6548\u679c\u8f83\u5dee\uff0c\u672c\u6307\u5357\u63a8\u8350\u5f00\u5c55\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff0c\u4ee5\u63a2\u7d22\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\u3002c \u5bf9\u4e8e\u4e00\u7ebf\u6cbb\u7597\u540e\u4f53\u80fd\u72b6\u6001\u4ecd\u80fd\u8010\u53d7\u5316\u7597\u7684\u60a3\u8005\uff0c\u63a8\u8350\u4e8c\u7ebf\u6cbb\u7597\u3002<\/p>\n
d \u4e8c\u7ebf\u6cbb\u7597\u540e\uff0c\u65e0\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u8868\u660e\u591a\u7ebf\u5316\u7597\u53ef\u5ef6\u957f\u751f\u5b58\uff0c\u4e5f\u65e0\u660e\u786e\u7684\u6709\u6548\u836f\u7269\uff0c\u4f46\u5bf9\u4f53\u80fd\u72b6\u6001\u826f\u597d\u7684\u60a3\u8005\uff0c\u53ef\u5c06\u4e00\u7ebf\u672a\u4f7f\u7528\u836f\u7269\u7528\u4e8e\u540e\u7ebf\u6cbb\u7597(\u8be6\u89c1\u9644\u5f559)\u3002<\/p>\n
e \u51cf\u75c7\u653e\u7597\u662f\u901a\u8fc7\u7167\u5c04\u539f\u53d1\u6216\u8f6c\u79fb\u75c5\u7076\uff0c\u63a7\u5236\u6216\u7f29\u5c0f\u75c5\u7076\uff0c\u4ee5\u7f13\u89e3\u60a3\u8005\u6897\u963b\u3001\u538b\u8feb\u6216\u75bc\u75db\u75c7\u72b61\uff0c\u6539\u5584\u751f\u5b58\u8d28\u91cf\u4e3a\u76ee\u7684\u7684\u653e\u7597\u6a21\u5f0f\uff0c\u901a\u5e38\u4e0d\u505a\u9884\u9632\u6027\u7167\u5c04\uff0c\u6cbb\u7597\u5206\u6b21\u5c11\u3002\u5be1\u8f6c\u79fb\u80f0\u817a\u764c\u5728\u63d0\u4f9b\u7cbe\u51c6\u7167\u5c04\u7684\u524d\u63d0\u4e0b\uff0c\u53ef\u9488\u5bf9\u6240\u6709\u53ef\u89c1\u75c5\u7076\u7ed9\u4e88\u9ad8\u5242\u91cf\u653e\u7597\uff0c\u8fbe\u5230\u63d0\u9ad8\u7597\u6548\u7684\u76ee\u7684\u3002<\/p>\n
f \u591a\u9879\u4e34\u5e8a\u7814\u7a76\u63d0\u793a\u4e00\u7ebf\u5316\u7597\u540e\u4f7f\u7528\u7ef4\u6301\u6cbb\u7597\u53ef\u4f7f\u60a3\u8005\u83b7\u76ca\u3002\u6839\u636ePOLO\u4e34\u5e8a\u7814\u7a76\uff0c\u5bf9\u4e8e\u5b58\u5728 BRCAI\/2\u80da\u7cfb\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u5728\u4e00\u7ebf\u542b\u94c2\u7c7b\u65b9\u6848\u5316\u7597\u540e\u4f7f\u7528\u5965\u62c9\u5e15\u5229\u7ef4\u6301\u6cbb\u7597\u53ef\u663e\u8457\u5ef6\u957fPFS(7.4\u4e2a\u6708vs.3.8\u4e2a\u6708\uff0cP=0.004)[2]\u3002\u4e00\u9879\u56fd\u5185\u5f00\u5c55\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5728\u665a\u671f\u80f0\u817a\u764c\u4e2d\uff0c\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\u8054\u5408\u66ff\u5409\u5965(AS\u65b9\u6848)\u4e00\u7ebf\u6cbb\u7597\u540e\u66ff\u5409\u5965(S)\u7ef4\u6301\u6cbb\u7597\uff0cPFS\u4e3a6.2\u4e2a\u6708\uff0cOS\u4e3a13.6 \u4e2a\u6708[3]\u3002\u53e6\u4e00\u9879\u56fd\u5916\u5f00\u5c55\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\u8054\u5408\u5409\u897f\u4ed6\u6ee8(AG\u65b9\u6848)\u540e\u5409\u897f\u4ed6\u6ee8(GEM)\u7ef4\u6301\u6cbb\u7597\uff0cPFS\u4e3a6.4\u4e2a\u6708\uff0cOS\u4e3a13.4\u4e2a\u6708[4]\u3002<\/p>\n
g \u5bf9\u4e8e\u4f34\u6709\u809d\u8f6c\u79fb\u3001\u80ba\u8f6c\u79fb\u7b49\u7684\u60a3\u8005\uff0c\u53ef\u5728\u5168\u8eab\u80bf\u7624\u63a7\u5236\u826f\u597d\u7684\u60c5\u51b5\u4e0b\uff0c\u5bf9\u8f6c\u79fb\u7076\u548c\u539f\u53d1\u7076\u9009\u62e9\u6027\u5730\u8fdb\u884c\u52a8\u8109\u6813\u585e\u5316\u7597\u3001\u5c04\u9891\u6d88\u878d\u7b49\u4ecb\u5165\u6cbb\u7597\u3002<\/p>\n<\/p>\n<\/p>\n
\u539f\u6587\u89e3\u8bfb\uff1a\u300a\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u80f0\u817a\u764c\u8bca\u7597\u6307\u5357 2024\u300b\uff08\u4e00\uff09\u524d\u8a00 \u8bca\u65ad<\/p>\n
\u56fd\u9645\u764c\u75c7\u5b66\u6742\u5fd7Cancers\uff1a\u5c40\u90e8\u665a\u671f\uff08III\u671f) \u80f0\u817a\u764c\u8fb9\u9645\u5ed3\u6e05\u4e0d\u53ef\u9006\u7535\u7a7f\u5b54\u7eb3\u7c73\u5200\u6cbb\u7597\uff0c\u7597\u6548\u7684\u7cfb\u7edf\u6027\u56de\u987e<\/p>\n
\u56fd\u9645\u80bf\u7624\u5b66\u524d\u6cbf\uff1a\u5c40\u90e8\u665a\u671f\u80f0\u817a\u764c\uff08LAPC\uff09\u4e0d\u53ef\u9006\u7535\u7a7f\u5b54\uff08IRE\uff09\u540e\u5316\u7597\u7ec4\u548c\u5355\u72ec\u5316\u7597\u7ec4\u7684\u751f\u5b58\u7387\u6bd4\u8f83\u6027\u7814\u7a76<\/p>\n
\u7f8e\u56fd\u809d\u80f0\u80c6\u534f\u4f1a\uff08AHPBA\uff09\uff1a\u591a\u4e2d\u5fc3\u5408\u4f5c\u3001\u524d\u77bb\u6027\u7814\u7a76\u3001\u4e0d\u53ef\u9006\u7535\u7a7f\u5b54\uff08IRE\uff09\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u80f0\u817a\u764c\uff08LAPC\uff09\u7597\u6548\u7684\u521d\u59cb\u8bc4\u4ef7<\/p>\n<\/p>\n
\u5468\u4e01\u534e\u6559\u6388\u548c\u80e1\u6cfd\u52c7\u4e3b\u4efb\u533b\u5e08\u7eb3\u7c73\u5200\u6cbb\u7597\u80f0\u817a\u764c\u624b\u672f\u4e2d<\/p>\n<\/p>\n
#artContent h1#artContent p img#artContent table<\/p>\n","protected":false},"excerpt":{"rendered":"
\u539f\u6587\u89e3\u8bfb\uff1a\u300a\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u80f0\u817a\u764c\u8bca\u7597\u6307\u5357 2024\u300b … \u7ee7\u7eed\u9605\u8bfb