{"id":43204,"date":"2024-11-04T05:10:38","date_gmt":"2024-11-04T05:10:38","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=43204"},"modified":"2024-11-04T05:10:38","modified_gmt":"2024-11-04T05:10:38","slug":"2024kdigoanca%e7%9b%b8%e5%85%b3%e6%80%a7%e8%a1%80%e7%ae%a1%e7%82%8e%e7%ae%a1%e7%90%86%e4%b8%b4%e5%ba%8a%e5%ae%9e%e8%b7%b5%e6%8c%87%e5%8d%97","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=43204","title":{"rendered":"2024KDIGO|ANCA\u76f8\u5173\u6027\u8840\u7ba1\u708e\u7ba1\u7406\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357"},"content":{"rendered":"<\/p>\n

9.1\u8bca\u65ad<\/p>\n

\u5b9e\u8df5\u8981\u70b99.1.1\uff1a\u5982\u679c\u4e34\u5e8a\u8868\u73b0\u4e0e\u5c0f\u8840\u7ba1\u708e\u76f8\u7b26\uff0c\u540c\u65f6\u9ad3\u8fc7\u6c27\u5316\u7269\u9176\uff08MPO\uff09\u6216\u86cb\u767d\u91763\uff08PR3\uff09-ANCA\u8840\u6e05\u5b66\u68c0\u6d4b\u5448\u9633\u6027\uff0c\u5728\u7b49\u5f85\u80be\u6d3b\u68c0\u6216\u80be\u6d3b\u68c0\u62a5\u544a\u671f\u95f4\uff0c\u4e0d\u5e94\u63a8\u8fdf\u542f\u52a8\u514d\u75ab\u6291\u5236\u6cbb\u7597\uff0c\u5c24\u5176\u662f\u75c5\u60c5\u8fc5\u901f\u6076\u5316\u7684\u60a3\u8005<\/p>\n<\/p>\n

\u5b9e\u8df5\u8981\u70b99.1.2\uff1aANCA\u76f8\u5173\u6027\u8840\u7ba1\u708e\uff08AAV\uff09\u60a3\u8005\u5e94\u5728\u5177\u6709AAV\u6cbb\u7597\u7ecf\u9a8c\u7684\u4e2d\u5fc3\u63a5\u53d7\u6cbb\u7597<\/p>\n

9.2 \u9884\u540e<\/p>\n

\u5b9e\u8df5\u8981\u70b99.2.3.1\uff1aANCA\u6301\u7eed\u9633\u6027\u3001ANCA\u6c34\u5e73\u5347\u9ad8\u6216ANCA\u7531\u9634\u8f6c\u9633\u53ef\u80fd\u9884\u793a\u7740\u672a\u6765\u75be\u75c5\u590d\u53d1\uff0c\u5728\u505a\u51fa\u6cbb\u7597\u51b3\u7b56\u65f6\u5e94\u5f53\u52a0\u4ee5\u8003\u8651<\/p>\n

9.3 \u6cbb\u7597<\/p>\n

9.3.1 \u8bf1\u5bfc\u6cbb\u7597<\/p>\n

\u5efa\u8bae9.3.1.1\uff1a\u5efa\u8bae\u7cd6\u76ae\u8d28\u6fc0\u7d20\u8054\u5408\u5229\u59a5\u6614\u5355\u6297\u6216\u73af\u78f7\u9170\u80fa\u4f5c\u4e3a\u65b0\u53d1AAV\u7684\u521d\u59cb\u6cbb\u7597\uff081B\uff09<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.1.1\uff1a\u80be\u810f\u53d7\u7d2f\u7684AAV\u60a3\u8005\u7684\u6cbb\u7597\u6d41\u7a0b<\/p>\n<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.1.2\uff1a\u5bf9\u4e8e\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387 (GFR) \u663e\u8457\u4e0b\u964d\u6216\u5feb\u901f\u4e0b\u964d\uff08\u8840\u6e05\u808c\u9150 [SCr] >4 mg\/dl [>354 \u03bcmol\/l]\uff09\u7684\u60a3\u8005\uff0c\u652f\u6301\u4f7f\u7528\u5229\u59a5\u6614\u5355\u6297\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u6570\u636e\u6709\u9650\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u73af\u78f7\u9170\u80fa\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff0c\u4ee5\u53ca\u5229\u59a5\u6614\u5355\u6297\u548c\u73af\u78f7\u9170\u80fa\u8054\u7528<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.1.3\uff1a\u9009\u62e9\u5229\u59a5\u6614\u5355\u6297\u6216\u73af\u78f7\u9170\u80fa\u8fdb\u884c\u8bf1\u5bfc\u6cbb\u7597\u7684\u8003\u8651\u56e0\u7d20<\/p>\n<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.1.4\uff1a\u9009\u62e9\u73af\u78f7\u9170\u80fa\u7ed9\u836f\u9014\u5f84\u7684\u8003\u8651\u56e0\u7d20<\/p>\n<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.1.5\uff1a\u5bf9\u4e8e\u7ef4\u6301\u900f\u6790\u4e14\u6ca1\u6709\u4efb\u4f55\u80be\u5916\u8868\u73b0\u7684\u60a3\u8005\uff0c3\u4e2a\u6708\u540e\u53ef\u4ee5\u8003\u8651\u505c\u7528\u514d\u75ab\u6291\u5236\u6cbb\u7597<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.1.6\uff1a\u53e3\u670d\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u51cf\u91cf\u65b9\u6848\u5efa\u8bae<\/p>\n<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.1.7\uff1aAvacopan\u53ef\u7528\u4f5c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u66ff\u4ee3\u836f\u7269\u3002\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6bd2\u526f\u4f5c\u7528\u98ce\u9669\u9ad8\u7684\u60a3\u8005\u6700\u53ef\u80fd\u4eceavacopan\u4e2d\u83b7\u76ca\u3002GFR\u8f83\u4f4e\u7684\u60a3\u8005\u53ef\u80fd\u53d7\u76ca\u4e8e\u66f4\u5927\u7a0b\u5ea6\u7684GFR \u6062\u590d\u3002<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.1.8\uff1a\u514d\u75ab\u6291\u5236\u5242\u5242\u91cf\u63a8\u8350<\/p>\n<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.1.9\uff1a\u5bf9\u4e8eSCr >3.4 mg\/dl\uff08>300 \u03bcmol\/l\uff09\u3001\u9700\u8981\u900f\u6790\u6216 SCr \u5feb\u901f\u5347\u9ad8\u7684\u60a3\u8005\u4ee5\u53ca\u4f34\u6709\u4f4e\u6c27\u8840\u75c7\u7684\u5f25\u6f2b\u6027\u80ba\u6ce1\u51fa\u8840\u60a3\u8005\uff0c\u8003\u8651\u8840\u6d46\u7f6e\u6362<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.1.10\uff1a\u5bf9ANCA\u76f8\u5173\u8840\u7ba1\u708e\u5408\u5e76\u6297\u80be\u5c0f\u7403\u57fa\u5e95\u819c\uff08GBM\uff09\u7684\u60a3\u8005\u52a0\u7528\u8840\u6d46\u7f6e\u6362<\/p>\n

9.3.2 \u7ef4\u6301\u6cbb\u7597<\/p>\n

\u5efa\u8bae9.3.2.1\uff1a\u5efa\u8bae\u5728\u8bf1\u5bfc\u7f13\u89e3\u540e\u4f7f\u7528\u5229\u59a5\u6614\u5355\u6297\u6216\u786b\u5511\u560c\u5464\u548c\u5c0f\u5242\u91cf\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7ef4\u6301\u6cbb\u7597\uff081C\uff09<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.2.1\uff1a\u5229\u59a5\u6614\u5355\u6297\u8bf1\u5bfc\u6cbb\u7597\u540e\uff0c\u5927\u591a\u6570\u60a3\u8005\u5e94\u63a5\u53d7\u7ef4\u6301\u6027\u514d\u75ab\u6291\u5236\u6cbb\u7597<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.2.2\uff1a\u8bf1\u5bfc\u7f13\u89e3\u540e\u7ef4\u6301\u7f13\u89e3\u6cbb\u7597\u7684\u6700\u4f73\u6301\u7eed\u65f6\u95f4\u662f18\u6708\u81f34\u5e74<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.2.3\uff1a\u5728\u8003\u8651\u505c\u7528\u7ef4\u6301\u6cbb\u7597\u65f6\uff0c\u5e94\u8003\u8651\u590d\u53d1\u7684\u98ce\u9669\uff0c\u5e76\u544a\u77e5\u60a3\u8005\u5982\u679c\u75c7\u72b6\u590d\u53d1\u9700\u8981\u53ca\u65f6\u5173\u6ce8<\/p>\n<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.2.4\uff1a\u5bf9\u786b\u5511\u560c\u5464\u4e0d\u8010\u53d7\u7684\u60a3\u8005\uff0c\u8003\u8651\u5417\u66ff\u9ea6\u8003\u915a\u916f (MMF) \u6216\u7532\u6c28\u8776\u5464\u4f5c\u4e3a\u786b\u5511\u560c\u5464\u7684\u66ff\u4ee3\u836f\u7269\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597\u3002\u7532\u6c28\u8776\u5464\u4e0d\u5e94\u7528\u4e8eGFR <60 ml\/min\/1.73 m2 <\/sup>\u7684\u60a3\u8005<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.2.5\uff1a\u9009\u62e9\u5229\u59a5\u6614\u5355\u6297\u6216\u786b\u5511\u560c\u5464\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597\u7684\u8003\u8651\u56e0\u7d20<\/p>\n<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.2.6\uff1a\u7ef4\u6301\u6cbb\u7597\u836f\u7269\u5242\u91cf\u548c\u6301\u7eed\u65f6\u95f4\u63a8\u8350<\/p>\n<\/p>\n

9.3.3 \u590d\u53d1\u7684\u6cbb\u7597<\/p>\n

\u5b9e\u8df5\u8981\u70b99.3.3.1\uff1a\u75be\u75c5\u590d\u53d1\uff08\u4e25\u91cd\u810f\u5668\u635f\u5bb3\u6216\u5371\u53ca\u751f\u547d\uff09\u7684\u60a3\u8005\u5e94\u91cd\u65b0\u8bf1\u5bfc\u7f13\u89e3\uff08\u5efa\u8bae 9.3.1.1\uff09\uff0c\u9996\u9009\u5229\u59a5\u6614\u5355\u6297<\/p>\n

9.4 \u7279\u6b8a\u60c5\u51b5<\/p>\n

9.4.1 \u96be\u6cbb\u6027AAV<\/p>\n

\u5b9e\u8df5\u8981\u70b99.4.1.1\uff1a\u96be\u6cbb\u6027AAV\u53ef\u4ee5\u901a\u8fc7\u589e\u52a0\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\uff08\u9759\u8109\u6216\u53e3\u670d\uff09\u6cbb\u7597\uff0c\u5982\u679c\u5148\u524d\u5df2\u4f7f\u7528\u73af\u78f7\u9170\u80fa\u8bf1\u5bfc\u7f13\u89e3\uff0c\u5219\u53ef\u4ee5\u52a0\u7528\u5229\u59a5\u6614\u5355\u6297\uff0c\u53cd\u4e4b\u4ea6\u7136\u3002\u53ef\u4ee5\u8003\u8651\u8840\u6d46\u7f6e\u6362<\/p>\n

\u5b9e\u8df5\u8981\u70b99.4.1.2\uff1a\u5728\u5f25\u6f2b\u6027\u80ba\u6ce1\u51fa\u8840\u4f34\u4f4e\u6c27\u8840\u75c7\u7684\u60c5\u51b5\u4e0b\uff0c\u9664\u4e86\u7cd6\u76ae\u8d28\u6fc0\u7d20\u8054\u5408\u73af\u78f7\u9170\u80fa\u6216\u5229\u59a5\u6614\u5355\u6297\u5916\uff0c\u8fd8\u53ef\u4ee5\u8003\u8651\u8840\u6d46\u7f6e\u6362<\/p>\n

9.4.2 \u79fb\u690d<\/p>\n

\u5b9e\u8df5\u8981\u70b99.4.2.1\uff1a\u63a8\u8fdf\u80be\u79fb\u690d\u76f4\u81f3\u60a3\u8005\u5b8c\u5168\u4e34\u5e8a\u7f13\u89e3\u22656\u4e2a\u6708\u3002ANCA\u6301\u7eed\u9633\u6027\u65e0\u9700\u63a8\u8fdf\u80be\u79fb\u690d<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"

9.1\u8bca\u65ad \u5b9e\u8df5\u8981\u70b99.1.1\uff1a\u5982\u679c\u4e34\u5e8a\u8868\u73b0\u4e0e\u5c0f\u8840\u7ba1\u708e\u76f8\u7b26\uff0c\u540c\u65f6\u9ad3\u8fc7\u6c27\u5316\u7269\u9176\uff08M … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-43204","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/43204","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43204"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/43204\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43204"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43204"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43204"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}