{"id":41721,"date":"2024-10-02T05:10:15","date_gmt":"2024-10-02T05:10:15","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=41721"},"modified":"2024-10-02T05:10:15","modified_gmt":"2024-10-02T05:10:15","slug":"%e8%86%9c%e6%80%a7%e8%82%be%e7%97%85%e5%92%8ciga%e8%82%be%e7%97%85%e7%9a%84%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e4%b8%a8ear-2024","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=41721","title":{"rendered":"\u819c\u6027\u80be\u75c5\u548cIgA\u80be\u75c5\u7684\u7814\u7a76\u8fdb\u5c55\u4e28EAR 2024"},"content":{"rendered":"<p>\u7f16\u8005\u6309<\/p>\n<\/p>\n<p>\u819c\u6027\u80be\u75c5\uff08MN\uff09\u548cIgA\u80be\u75c5\uff08IgAN\uff09\u662f\u4e24\u79cd\u5e38\u89c1\u7684\u539f\u53d1\u6027\u80be\u5c0f\u7403\u75be\u75c5\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u5bf9\u8fd9\u4e24\u79cd\u75be\u75c5\u53d1\u75c5\u673a\u5236\u7684\u6df1\u5165\u7814\u7a76\uff0c\u9488\u5bf9\u7279\u5b9a\u9776\u70b9\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u5982\u9776\u5411\u8865\u4f53\u6216B\u7ec6\u80de\u6cbb\u7597\uff0c\u9010\u6e10\u6210\u4e3a\u7814\u7a76\u7684\u70ed\u70b9\u3002\u57282024\u5e74\u7b2c61\u5c4a\u6b27\u6d32\u80be\u810f\u534f\u4f1a\u5e74\u4f1a\uff08ERA 2024\uff09\u4e0a\uff0c\u6765\u81ea\u5fb7\u56fd\u6c49\u5821\u57c3\u5f6d\u591a\u592b\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u7684Nicola M Tomas\u6559\u6388\u548c\u82f1\u56fd\u83b1\u65af\u7279\u5927\u5b66\u7684Jonathan Barratt\u56f4\u7ed5MN\u548cIgAN\u7684\u6700\u65b0\u8fdb\u5c55\u8fdb\u884c\u9610\u8ff0\u3002<\/p>\n<p>\u819c\u6027\u80be\u75c5\u2014\u2014\u9776\u5411\u8865\u4f53\u8fd8\u662f\u6d46\u7ec6\u80de\u6cbb\u7597\uff1f<\/p>\n<p>MN\u662f\u80be\u75c5\u7efc\u5408\u5f81\u6700\u5e38\u89c1\u7684\u75c5\u7406\u7c7b\u578b\u4e4b\u4e00\uff0c\u4e34\u5e8a\u8868\u73b0\u4e3a\u86cb\u767d\u5c3f\u3001\u4f4e\u86cb\u767d\u8840\u75c7\u3001\u9ad8\u8102\u8840\u75c7\u548c\u6c34\u80bf\uff0c\u90e8\u5206\u60a3\u8005\u8fd8\u4f34\u968f\u9ad8\u8840\u538b\u3001\u8840\u5c3f\u7b49\u3002MN\u7684\u53d1\u75c5\u673a\u5236\u4e3b\u8981\u662f\u8db3\u7ec6\u80de\u81ea\u8eab\u6297\u539f\uff0c\u5982\u78f7\u8102\u9176A2\u53d7\u4f53\uff08PLA2R\uff09\u548c\u2160\u578b\u8840\u5c0f\u677f\u53cd\u5e94\u86cb\u767d7A\u57df\uff08THSD7A\uff09\u7b49\uff0c\u8bf1\u53d1\u7684\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u6fc0\u6d3b\u3002\u514d\u75ab\u590d\u5408\u7269\u7684\u5f62\u6210\u548c\u6c89\u79ef\u662fMN\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5b83\u4eec\u53ef\u4ee5\u6fc0\u6d3b\u7ec6\u80de\u5185\u7684\u4fe1\u53f7\u4f20\u5bfc\u9014\u5f84\uff0c\u5bfc\u81f4\u7ec6\u80de\u589e\u6b96\u3001\u708e\u75c7\u548c\u7ea4\u7ef4\u5316\u7b49\u3002\u6297\u4f53\u548c\u8865\u4f53\u7684\u6c89\u79ef\u4ee5\u53ca\u968f\u540e\u5f15\u53d1\u7684\u514d\u75ab\u53cd\u5e94\u548c\u708e\u75c7\u53cd\u5e94\uff0c\u6700\u7ec8\u5bfc\u81f4\u80be\u810f\u635f\u4f24\uff0c\u5982\u80be\u5c0f\u7403\u786c\u5316\u3001\u80be\u5c0f\u7ba1\u95f4\u8d28\u7ea4\u7ef4\u5316\u548c\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\u4e0b\u964d\u3002\u56e0\u6b64\uff0c\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u514d\u75ab\u53cd\u5e94\u548c\u51cf\u5c11\u8865\u4f53\u6fc0\u6d3b\u7b49\u63aa\u65bd\u51cf\u8f7bMN\u7684\u8fdb\u5c55\u3002MN\u4e0e\u8865\u4f53\u7cfb\u7edf\u8fc7\u5ea6\u6fc0\u6d3b\u6709\u5173\uff0c\u9776\u5411\u8865\u4f53\u7597\u6cd5\u53ef\u4ee5\u963b\u65ad\u8865\u4f53\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94\u5bf9\u80be\u5c0f\u7403\u7684\u635f\u4f24\uff0c\u6709\u7f13\u89e3\u86cb\u767d\u5c3f\u548c\u80be\u529f\u80fd\u6076\u5316\u7684\u8d8b\u52bf\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0cMN\u60a3\u8005\u4e2d\u5b58\u5728\u4e09\u79cd\u8865\u4f53\u9014\u5f84\uff08\u7ecf\u5178\u9014\u5f84\uff0c\u65c1\u8def\u9014\u5f84\u548cMBL\u9014\u5f84\uff09\u7684\u6210\u5206\uff0c\u5176\u4e3b\u8981\u901a\u8fc7\u7ecf\u5178\u9014\u5f84\u6fc0\u6d3b\u8865\u4f53\u3002MN\u7684\u6297\u539f\u7279\u5f02\u6027\u81ea\u8eab\u514d\u75ab\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u8865\u4f53\u7f3a\u9677\u5c0f\u9f20\u7684\u80be\u5c0f\u7403\u635f\u4f24\u548c\u86cb\u767d\u5c3f\u51cf\u5c11\uff0c\u9776\u5411\u8865\u4f53\u6210\u5206\uff08\u5982C3\uff09\u53ef\u80fd\u662f\u4e00\u79cd\u6709\u524d\u9014\u7684\u6cbb\u7597\u7b56\u7565\u3002MN\u60a3\u8005\u5b58\u5728\u6d46\u7ec6\u80de\u5f02\u5e38\u589e\u6b96\uff0c\u9776\u5411\u6d46\u7ec6\u80de\u7684\u7597\u6cd5\u53ef\u4ee5\u963b\u65ad\u514d\u75ab\u53cd\u5e94\u7684\u6301\u7eed\u6fc0\u6d3b\uff0c\u5bf9\u4e8e\u51cf\u8f7bMN\u4e5f\u5c55\u73b0\u4e86\u663e\u8457\u7684\u4f18\u52bf\u3002\u76ee\u524d\u9776\u5411\u6297\u4f53\u5206\u6ccc\u7ec6\u80de\uff08B\u7ec6\u80de\uff09\u7684\u5355\u514b\u9686\u6297\u4f53\u6709\u5229\u59a5\u6614\u5355\u6297\uff08Rituximab\uff0cRTX\uff09\u3001\u5965\u59a5\u73e0\u5355\u6297\uff08Obinutuzumab\uff09\u3001\u5965\u6cd5\u59a5\u6728\u5355\u6297\uff08Ofatumumab\uff09\u7b49\uff08\u56fe1\uff09\u3002RTX\u901a\u8fc7\u4e0eB\u7ec6\u80de\u8868\u9762\u7684CD20\u6297\u539f\u7ed3\u5408\uff0c\u8bf1\u5bfcB\u7ec6\u80de\u51cb\u4ea1\u5e76\u51cf\u5c11B\u7ec6\u80de\u6570\u91cf\uff0c\u51cf\u8f7b\u514d\u75ab\u53cd\u5e94\u7684\u6301\u7eed\u6fc0\u6d3b\uff0c\u4ece\u800c\u51cf\u5c11\u514d\u75ab\u590d\u5408\u7269\u5728\u80be\u5c0f\u7403\u6c89\u79ef\u3002\u6539\u5584\u5168\u7403\u80be\u810f\u75c5\u9884\u540e\u7ec4\u7ec7\uff08KDIGO\uff09\u6307\u5357\u4e5f\u5efa\u8bae\u5c06RTX\u7528\u4e8e\u6cbb\u7597MN\u3001\u5fae\u5c0f\u75c5\u53d8\u80be\u75c5\u3001\u72fc\u75ae\u80be\u708e\u7b49\u80be\u5c0f\u7403\u75be\u75c5\u3002Gemritux\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u5bf9\u6bd4\u4e86 RTX\u8054\u5408\u652f\u6301\u7597\u6cd5\u548c\u5355\u7eaf\u652f\u6301\u7597\u6cd5\u6cbb\u7597MN\u60a3\u8005\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4e24\u7ec4\u5c3f\u86cb\u767d\u548c\u8840\u6e05\u767d\u86cb\u767d\u8f83\u57fa\u7ebf\u5747\u660e\u663e\u6539\u5584\uff0c\u800cRTX\u8054\u5408\u652f\u6301\u7597\u6cd5\u7684\u60a3\u8005\u6297PLA2R\u6297\u4f53\u6c34\u5e73\u8f83\u5355\u7eaf\u652f\u6301\u7597\u6cd5\u6cbb\u7597\u663e\u8457\u4e0b\u964d\u3002MENTOR\u7684\u2162\u671f RCT\u6bd4\u8f83\u4e86\u73af\u5b62A\u6216RTX\u7684\u7597\u6548\uff0c\u7ed3\u679c\u663e\u793a\uff0cRTX\u572824\u4e2a\u6708\u65f6\u7ef4\u6301\u86cb\u767d\u5c3f\u7f13\u89e3\u7387\u4f18\u4e8e\u73af\u5b62\u7d20 A\uff0c\u6297 PLA2R \u6297\u4f53\u6c34\u5e73\u4e0b\u964d\u7a0b\u5ea6\u66f4\u5feb\uff0c\u6301\u7eed\u65f6\u95f4\u66f4\u957f\u3002RI-CYCLO\u7684\u4e00\u9879RCT\u53d1\u73b0\uff0cRTX\u4e0e\u7cd6\u76ae\u8d28\u6fc0\u7d20-\u73af\u78f7\u9170\u80fa\u76f8\u6bd4\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u53ef\u4ee5\u4f5c\u4e3aMN\u4e00\u7ebf\u6216\u8005\u590d\u53d1\u540e\u7684\u6cbb\u7597\u9009\u62e9\u3002\u800cSTARMEN\u8bd5\u9a8c\u8ba4\u4e3a\u4e0e\u4ed6\u514b\u83ab\u53f8-RTX\u6cbb\u7597\u76f8\u6bd4\uff0c\u6fc0\u7d20-\u73af\u78f7\u9170\u80fa\u4ea4\u66ff\u6cbb\u7597\u6548\u679c\u66f4\u597d\u30022021\u5e74KDIGO\u6307\u5357\u5efa\u8bae\u5177\u6709\u9ad8\u98ce\u9669\u7684\u539f\u53d1\u6027MN\u60a3\u8005\u91c7\u75286\u4e2a\u6708\u6fc0\u7d20-\u73af\u78f7\u9170\u80fa\u5faa\u73af\u5468\u671f\u6cbb\u7597\uff0c\u4e2d\u9ad8\u98ce\u9669\u7684\u60a3\u8005\u53ef\u4ee5\u8054\u5408RTX\u6cbb\u7597\u3002\u9664\u4e86\u6297CD20\u5355\u6297\u5916\uff0c\u6297CD38\u5355\u6297\u4e5f\u662f\u6cbb\u7597MN\u7684\u6f5c\u5728\u6709\u6548\u7b56\u7565\u4e4b\u4e00\u3002M-PLACE\u4f5c\u4e3a\u4e00\u9879Ib\/IIa\u671f\u3001\u5f00\u653e\u6807\u7b7e\u3001\u56fd\u9645\u591a\u4e2d\u5fc3\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u53d1\u73b0\u4e86\u83f2\u6cfd\u59a5\u5355\u6297\uff08Felzartamab\uff09\u662f\u4e00\u79cd\u65b0\u578b\u7684CD38\u5355\u6297\uff0c\u53ef\u6709\u6548\u8017\u7aed\u6d46\u7ec6\u80de\uff0c\u5df2\u83b7\u7f8e\u56fdFDA\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002<\/p>\n<p>\u56fe1. \u9776\u5411\u6297\u4f53\u5206\u6ccc\u7ec6\u80de\uff08B\u7ec6\u80de\uff09\u7684\u5355\u514b\u9686\u6297\u4f53\u76ee\u524d\u7684\u5b9e\u9a8c\u6027\u7814\u7a76\u53d1\u73b0\u8865\u4f53\u7cfb\u7edf\u5bf9MN\u6709\u81f4\u75c5\u4f5c\u7528\uff0c\u4f46\u4e34\u5e8a\u8bd5\u9a8c\u672a\u80fd\u9a8c\u8bc1\u8fd9\u4e00\u7ed3\u679c\uff0c\u95f4\u63a5\u6e05\u9664\u6297\u4f53\u5206\u6ccc\u7ec6\u80de\u53ef\u80fd\u662fMN\u7684\u4e3b\u8981\u6cbb\u7597\u65b9\u6cd5\uff0c\u514d\u75ab\u6291\u5236\u6cbb\u7597MN\u7684\u65b9\u6848\u8fd8\u5b58\u5728\u8f83\u5927\u4e89\u8bae\uff0c\u672a\u6765\u8fd8\u9700\u8981\u66f4\u591a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u636e\uff0c\u4e3a\u4f18\u5316MN\u7684\u6cbb\u7597\u65b9\u6848\u63d0\u4f9b\u652f\u6301\u3002<\/p>\n<p>IgAN\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c<\/p>\n<p>IgAN\uff0c\u4e5f\u88ab\u79f0\u4e3abergers\u75c5\uff0c\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u6162\u6027\u80be\u5c0f\u7403\u80be\u708e\uff0c\u5176\u4e3b\u8981\u75c5\u7406\u7279\u5f81\u662f\u80be\u5c0f\u7403\u7cfb\u819c\u533a\u4ee5IgA\u4e3a\u4e3b\u7684\u514d\u75ab\u7403\u86cb\u767d\u6c89\u79ef\u3002\u8840\u5c3f\u662fIgAN\u6700\u5e38\u89c1\u7684\u4e34\u5e8a\u8868\u73b0\uff0c\u901a\u5e38\u4e3a\u65e0\u75db\u6027\u3001\u8089\u773c\u8840\u5c3f\uff0c\u53ef\u5728\u77ed\u65f6\u95f4\u5185\u51fa\u73b0\uff0c\u6301\u7eed\u65f6\u95f4\u4ece\u51e0\u5929\u5230\u51e0\u5468\u4e0d\u7b49\u3002\u90e8\u5206\u60a3\u8005\u51fa\u73b0\u8f7b\u81f3\u4e2d\u5ea6\u86cb\u767d\u5c3f\uff0c\u53ef\u4f34\u968f\u6c34\u80bf\u3001\u9ad8\u8840\u538b\u548c\u80be\u529f\u80fd\u964d\u4f4e\u3002IgAN\u7684\u53d1\u75c5\u673a\u5236\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\uff0c\u4f46\u514d\u75ab\u7cfb\u7edf\u5f02\u5e38\u548c\u9057\u4f20\u56e0\u7d20\u53ef\u80fd\u4e0e\u75be\u75c5\u7684\u53d1\u5c55\u6709\u5173\u3002\u5bf9\u4e8e\u80be\u6d3b\u68c0\u786e\u8bcaIgAN\u7684\u60a3\u8005\uff0c\u9700\u8981\u4ece\u4e24\u4e2a\u65b9\u9762\u8fdb\u884c\u7ba1\u7406\uff0c\u4e00\u65b9\u9762\u662f\u89e3\u51b3\u514d\u75ab\u548c\u708e\u75c7\u9a71\u52a8\u7684\u6301\u7eed\u80be\u5355\u4f4d\u4e22\u5931\uff0c\u53e6\u4e00\u65b9\u9762\u662f\u89e3\u51b3\u6162\u6027\u80be\u810f\u75c5\u9a71\u52a8\u7684\u6301\u7eed\u80be\u5355\u4f4d\u4e22\u5931\uff08\u56fe2\uff09\u3002<\/p>\n<p>\u56fe 2. IgA\u80be\u75c5\u6cbb\u7597\u7b56\u7565B\u7ec6\u80de\u8017\u7aed\u548cB\u7ec6\u80de\u8c03\u8282\u7597\u6cd5\u662f\u7f13\u89e3\u81f4\u75c5\u6027IgA\u5408\u6210\u7684\u91cd\u8981\u7b56\u7565\u3002\u5927\u91cf\u6570\u636e\u8868\u660e\uff0c\u86cb\u767d\u5c3f\u51cf\u5c11\u53ef\u4f5c\u4e3aIgAN\u8fdb\u5c55\u7684\u4e34\u5e8a\u66ff\u4ee3\u7ec8\u70b9\u3002\u4e00\u9879RTX\u6cbb\u7597IgAN\u7684\u7814\u7a76\u53d1\u73b0\uff0cRTX\u6709\u6548\u5730\u6d88\u8017\u4e86B\u7ec6\u80de\uff0c\u4f46\u5b83\u672a\u80fd\u964d\u4f4e\u534a\u4e73\u7cd6\u7f3a\u4e4f\u578bIgA1\u548c\u6297\u534a\u4e73\u7cd6\u7f3a\u4e4f\u578bIgA1\u6297\u4f53\u7684\u8840\u6e05\u6c34\u5e73\uff0c1\u5e74\u5185\u80be\u529f\u80fd\u548c\u86cb\u767d\u5c3f\u6ca1\u6709\u663e\u8457\u6539\u5584\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u672a\u80fd\u964d\u4f4eIgA\u80be\u75c5\u4e2d\u5177\u6709\u663e\u8457\u81f4\u75c5\u4f5c\u7528\u7684\u7279\u5f02\u6027\u6297\u4f53\u6c34\u5e73\u3002Mezagitamab\uff08TAK-079\uff09\u4f5c\u4e3a\u4e00\u79cd\u5bf9CD38\u9ad8\u4eb2\u548c\u529b\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u901a\u8fc7\u6297\u4f53\u548c\u8865\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\u6d88\u8017\u8868\u8fbeCD38\u7684B\u7ec6\u80de\uff0c\u5728\u63a5\u53d7\u7a33\u5b9a\u80cc\u666f\u6cbb\u7597\u7684\u539f\u53d1\u6027IgAN\u6210\u4eba\u60a3\u8005\u4e2d\u53d6\u5f97\u4e86\u4e00\u5b9a\u7684\u7597\u6548\u3002\u4e00\u9879\u524d\u77bb\u6027\u7814\u7a76\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u660e\uff0cSibeprenlimab\uff08\u4e00\u79cd\u4eba\u6e90\u5316IgG2\u5355\u514b\u9686\u6297\u4f53\uff09\u901a\u8fc7\u7ed3\u5408\u5e76\u4e2d\u548c\u589e\u6b96\u8bf1\u5bfc\u914d\u4f53\uff08APRIL\uff09\uff0c\u6709\u6548\u963b\u6b62\u673a\u4f53\u5185\u534a\u4e73\u7cd6\u7f3a\u9677\u578bIgA1\u751f\u6210\uff0c\u663e\u8457\u964d\u4f4e\u4e86IgAN\u60a3\u8005\u7684\u5c3f\u86cb\u767d\uff0c\u5ef6\u7f13\u4e86\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\u4e0b\u964d\uff0c\u4ece\u800c\u6709\u6548\u63a7\u5236IgAN\u8fdb\u5c55\u3002\u6700\u8fd1\u7684\u7814\u7a76\u53d1\u73b0BION-1301\u3001Atacicept\u3001povetacicept\u7b49\u5355\u514b\u9686\u6297\u4f53\uff0c\u4e5f\u88ab\u8bc1\u5b9e\u80fd\u591f\u963b\u65adAPRIL\uff0c\u6291\u5236B\u7ec6\u80de\u7684\u5b58\u6d3b\uff0c\u8fdb\u800c\u51cf\u5c11\u4e86IgAN\u60a3\u8005\u81f4\u75c5\u6027\u6297\u4f53\u4ea7\u751f\uff0c\u8fbe\u5230\u4e86\u7f13\u89e3IgAN\u8fdb\u5c55\u7684\u76ee\u7684\u3002\u6b64\u5916\uff0c\u5e94\u7528\u8865\u4f53\u6291\u5236\u5242\u51cf\u8f7b\u80be\u5c0f\u7403\u708e\u75c7\u5bf9\u4e8e\u6cbb\u7597IgAN\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002Iptacopan\u662f\u4e00\u79cd\u9776\u5411\u66ff\u4ee3\u8865\u4f53\u9014\u5f84\u7684B\u56e0\u5b50\u6291\u5236\u5242\uff0c\u80fd\u591f\u51cf\u5c11IgAN\u86cb\u767d\u5c3f\u7684\u4ea7\u751f\u3002IONIS-FB-LRx\u3001ALXN2050\u3001Ravulizumab\u3001ARO-C3\u7b49\u8865\u4f53\u6291\u5236\u5242\uff0c\u5728IgAN\u8868\u73b0\u51fa\u4e86\u8f83\u597d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u63a7\u5236\u8840\u538b\u3001\u51cf\u5c11\u80be\u5c0f\u7403\u9ad8\u6ee4\u8fc7\u548c\u86cb\u767d\u5c3f\u3001\u964d\u4f4e\u5fc3\u8840\u7ba1\u98ce\u9669\uff0c\u5bf9\u4e8e\u7ba1\u7406IgAN\u60a3\u8005\uff0c\u5ef6\u7f13\u5176\u5411\u6162\u6027\u80be\u810f\u75c5\u8fdb\u5c55\u4e5f\u81f3\u5173\u91cd\u8981\u3002\u4e00\u9879\u591a\u56fd\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u968f\u673a\u8bd5\u9a8c\uff08DAPA-CKD \u8bd5\u9a8c\uff09\u8bc4\u4f30\u4e86\u8fbe\u683c\u5217\u51c0\u5bf9IgAN\u60a3\u8005\u7684\u7597\u6548\uff0c\u53d1\u73b0\u8fbe\u683c\u5217\u51c0\u53ef\u4ee5\u964d\u4f4eIgA N\u60a3\u8005CKD\u8fdb\u5c55\u7684\u98ce\u9669\uff0c\u5e76\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u3002Sparsentan\u4f5c\u4e3a\u8840\u7ba1\u7d27\u5f20\u7d20\u2161\u53d7\u4f53\u62ee\u6297\u5242\uff08ARB\uff09\u548c\u80be\u4e0a\u817a\u7d20\u03b1 1\u53d7\u4f53\u62ee\u6297\u5242\uff08ERA\uff09\uff0c\u6bd4\u5355\u4e00\u7684\u964d\u538b\u836f\u66f4\u6709\u6548\u5730\u63a7\u5236\u8840\u538b\uff0c\u51cf\u7f13\u80be\u810f\u75be\u75c5\u8fdb\u5c55\u3002Atrasentan \u662f\u4e00\u79cd\u5f3a\u6548\u9ad8\u9009\u62e9\u6027\u5185\u76ae\u7d20A\uff08ETA\uff09\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u901a\u8fc7\u963b\u65ad\u80be\u5c0f\u7403\u7cfb\u819c\u7ec6\u80de\u589e\u6b96\uff0c\u5177\u6709\u6297\u708e\u548c\u6297\u7ea4\u7ef4\u5316\u4f5c\u7528\uff0c\u5e76\u901a\u8fc7\u964d\u4f4e\u80be\u5c0f\u7403\u56ca\u5185\u538b\u529b\u548c\u6ee4\u8fc7\u5c4f\u969c\u7684\u5927\u5206\u5b50\u901a\u900f\u6027\u6765\u51cf\u5c11 IgA\u60a3\u8005\u7684\u5c3f\u86cb\u767d\u3002<\/p>\n<p>\u603b\u7ed3<\/p>\n<p>MN\u548cIgAN\u7684\u4e34\u5e8a\u7814\u7a76\u5728\u53d1\u75c5\u673a\u5236\u3001\u6cbb\u7597\u65b9\u6cd5\u4e0a\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\u3002\u672a\u6765\uff0c\u968f\u7740\u5bf9\u80be\u5c0f\u7403\u75be\u75c5\u53d1\u75c5\u673a\u5236\u7684\u6df1\u5165\u4e86\u89e3\uff0c\u6709\u671b\u5728\u5f00\u53d1\u65b0\u578b\u6cbb\u7597\u65b9\u6cd5\u4e0a\u53d6\u5f97\u66f4\u5927\u7684\u7a81\u7834\u3002\u540c\u65f6\uff0c\u8fd8\u9700\u8981\u66f4\u591a\u7684\u4e34\u5e8a\u7814\u7a76\u6765\u9a8c\u8bc1\u8fd9\u4e9b\u65b0\u7597\u6cd5\u6216\u836f\u7269\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p>\u201c\u80be\u533b\u7ebf\u201d\u8bfb\u8005\u4e13\u5c5e\u5fae\u4fe1\u7fa4\u5efa\u597d\u4e86\uff0c\u5feb\u5feb\u52a0\u5165\u5427\u3002\u626b\u63cf\u201c\u80be\u533b\u7ebf\u201d\u5c0f\u52a9\u624b\u4e8c\u7ef4\u7801\uff08\u5fae\u4fe1\u53f7\uff1anephro-online\uff09\uff0c\u56de\u590d\u201c\u80be\u533b\u7ebf\u8bfb\u8005\u201d\uff0cta\u4f1a\u5c3d\u5feb\u62c9\u60a8\u5165\u7fa4\u6ef4\uff01<\/p>\n<\/p>\n<p>\uff08\u6765\u6e90\uff1a\u300a\u80be\u533b\u7ebf\u300b\u7f16\u8f91\u90e8\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f16\u8005\u6309 \u819c\u6027\u80be\u75c5\uff08MN\uff09\u548cIgA\u80be\u75c5\uff08IgAN\uff09\u662f\u4e24\u79cd\u5e38\u89c1\u7684\u539f\u53d1\u6027\u80be\u5c0f\u7403\u75be\u75c5\u3002\u8fd1 &hellip; <a href=\"http:\/\/zydq.1006ss.com\/?p=41721\">\u7ee7\u7eed\u9605\u8bfb <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-41721","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/41721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41721"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/41721\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41721"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=41721"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=41721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}