{"id":41610,"date":"2024-09-30T05:09:47","date_gmt":"2024-09-30T05:09:47","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=41610"},"modified":"2024-09-30T05:09:47","modified_gmt":"2024-09-30T05:09:47","slug":"2023-asco%e4%b8%a8pada-1%e7%a0%94%e7%a9%b6%e4%b8%ad%e9%9a%8f%e6%9c%ba%e5%88%86%e7%bb%84%e5%90%8eai%e6%88%96%e6%b0%9f%e7%bb%b4%e5%8f%b8%e7%be%a4%e8%81%94%e5%90%88%e5%93%8c%e6%9f%8f%e8%a5%bf%e5%88%a9","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=41610","title":{"rendered":"2023 ASCO\u4e28PADA-1\u7814\u7a76\u4e2d\u968f\u673a\u5206\u7ec4\u540eAI\u6216\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u54cc\u67cf\u897f\u5229\u6cbb\u7597\u4e0b\u7684ESR1\u7a81\u53d8\u52a8\u529b\u5b66\u548c\u7c7b\u578b"},"content":{"rendered":"

  \u524d\u8a00<\/p>\n

PADA-1 \u662f\u7b2c\u4e00\u4e2a\u63a2\u8ba8\u5982\u4f55\u5229\u7528\u8840\u6db2\u4e2dESR1 \u7a81\u53d8 \uff08bESR1mut\uff09\u76d1\u6d4b\u6765\u8fdb\u884c\u4e34\u5e8a\u5e72\u9884\u7684\u7814\u7a76\u3002\u5728\u672c\u6b21ASCO\u4f1a\u8bae\u4e0a\uff0c\u516c\u5e03\u4e86\u968f\u673a\u5206\u7ec4\u540e\uff0c\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\uff08AI\uff09\u6216\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u54cc\u67cf\u897f\u5229\u6cbb\u7597\u4e0b\u7684ESR1\u7a81\u53d8\u52a8\u529b\u5b66\u548c\u7c7b\u578b\u3002<\/p>\n

  \u7814\u7a76\u80cc\u666f  <\/p>\n

\u5728PADA-1\u7814\u7a76\u4e2d\uff0c\u5c06\u5728AI \u8054\u5408\u54cc\u67cf\u897f\u5229\u4e00\u7ebf\u6cbb\u7597\u671f\u95f4bESR1mut\u5347\u9ad8\u7684ER+\/HER2-\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u968f\u673a\u5206\u914d\u4e3a\u7ee7\u7eed\u76f8\u540c\u6cbb\u7597\u6216\u8f6c\u7528\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u54cc\u67cf\u897f\u5229\uff08Bidard, Lancet Oncol 2022\uff09\u3002\u5728\u6b64\u5206\u6790\u4e2d\uff0c\u6211\u4eec\u7814\u7a76\u4e86\u968f\u673a\u5316\u540e\u5728\u4e24\u7ec4\u7684bESR1mut\u52a8\u529b\u5b66\u3002<\/p>\n

  \u7814\u7a76\u65b9\u6cd5  <\/p>\n

\u68c0\u6d4b\u5230bESR1mut\u5347\u9ad8\u4e14\u6ca1\u6709\u540c\u6b65\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u5728\u968f\u673a\u5316\u65f6\u63a5\u53d7\u8fdb\u4e00\u6b65\u7684\u8fde\u7eed ctDNA\u5206\u6790\uff0c\u968f\u540e\u6bcf2\u4e2a\u6708\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u3002\u968f\u673a\u5206\u7ec4\u65f6\u7684 ctDNA \u5206\u6790\uff08\u5373\u5728\u5185\u5206\u6ccc\u6cbb\u7597\u53d1\u751f\u4efb\u4f55\u53d8\u5316\u4e4b\u524d\uff09\u65e8\u5728\u7814\u7a76\u91c7\u6837\u6ce2\u52a8\u7684\u5f71\u54cd\u2014\u2014\u56e0\u4e3a\u5347\u9ad8\u7684bESR1mut\u6c34\u5e73\u901a\u5e38\u63a5\u8fd1\u68c0\u6d4b\u7684\u68c0\u6d4b\u9650\u3002bESR1mut\u68c0\u6d4b\u662f\u901a\u8fc7\u6db2\u6ef4\u6570\u5b57PCR\u8fdb\u884c\u7684\uff08Jeannot\uff0cOncogene 2020\uff09\uff0c\u5269\u4f59\u7684\u6837\u672c\u5219\u8fdb\u884c\u4e86\u4e8c\u4ee3\u6d4b\u5e8f\u4ee5\u8bc4\u4f30bESR1mut\u7a81\u53d8\u7c7b\u578b\u53ca\u514b\u9686\u6027\uff08Callens\uff0cAnal Chem 2022\uff09\u3002<\/p>\n

  \u7814\u7a76\u7ed3\u679c  <\/p>\n

172 \u540d\u60a3\u8005\u5728bESR1mut\u5347\u9ad8\u4e14\u65e0\u540c\u6b65\u75be\u75c5\u8fdb\u5c55\u540e\u88ab\u968f\u673a\u5206\u914d\u3002\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\uff0cbESR1mut \u7684\u4e2d\u4f4d\u7a81\u53d8\u7b49\u4f4d\u57fa\u56e0\u9891\u7387\u4e3a0.8%\uff08\u8303\u56f4 0.1-25.8%\uff09\uff0c\u201c\u4e0a\u5347\u201d\u6837\u672c\u7684\u4e2d\u4f4d\u62f7\u8d1d\u6570\u4e3a14\u62f7\u8d1d\/ml\u8840\u6d46\uff08\u8303\u56f44-1033\uff09\uff0c\u968f\u673a\u5206\u914d\u540e\u4e24\u7ec4\u57fa\u7ebf\u7279\u5f81\u5e73\u8861\u3002\u5176\u4e2d\uff0cN=75 \uff0846.6%\uff09 \u540d\u60a3\u8005\u5728\u968f\u673a\u5316\u7684\u91cd\u590d\u8840\u6837\u4e2d\u672a\u68c0\u6d4b\u5230bESR1mut\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0e\u90a3\u4e9b\u5728\u968f\u673a\u5316\u65f6\u4fdd\u6301bESR1mut\u9633\u6027\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u51fa\u73b0\u201c\u4e0a\u5347\u201d\u65f6\u7684bESR1mut\u6c34\u5e73\u8f83\u4f4e \uff08p=0.01\uff09\u3002<\/p>\n

\u6cbb\u7597\u5f00\u59cb\u540e\uff0c\u4e0e\u7ee7\u7eed\u4f7f\u7528\u54cc\u67cf\u897f\u5229\u8054\u5408AI \u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u8f6c\u4e3a\u4f7f\u7528\u54cc\u67cf\u897f\u5229\u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4\u7684\u60a3\u8005\u57282\u4e2a\u6708\u65f6\u7684bESR1mut\u6e05\u9664\u7387\u66f4\u9ad8\uff0870.9% vs. 32.8%\uff0cp<0.001\uff09\u3002\u800c2\u4e2a\u6708\u65f6 bESR1mut\u6e05\u9664\u4e0e\u66f4\u957f\u7684PFS\u76f8\u5173 \uff08HR=0.36\uff0c95%CI 0.25-0.52 p\uff1c0.001\uff09\u3002\u968f\u673a\u5206\u914d\u81f3\u54cc\u67cf\u897f\u5229\u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4\u7ec4\u7684\u60a3\u8005\u4fdd\u6301bESR1mut\u6e05\u9664\u7684\u65f6\u95f4\u4e5f\u66f4\u957f\uff08\u4e2d\u4f4d\u6570\uff1a7.3 \u4e2a\u6708[95%CI 3.7-11.2]  vs. 1.9\u4e2a\u6708 [95%CI 1.8-2.3]\uff1bp\uff1c0.001\uff09\u3002<\/p>\n

\u5728\u4e34\u5e8a\u75be\u75c5\u8fdb\u5c55\u65f6\uff0cN=62 \uff0883%\uff09 \u548c N=49 \uff0873%\uff09 \u60a3\u8005\u5206\u522b\u5728\u54cc\u67cf\u897f\u5229\u8054\u5408AI\u7ec4\u548c\u54cc\u67cf\u897f\u5229\u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4\u7ec4\u4e2d\u68c0\u6d4b\u51fabESR1mut\u9633\u6027\u3002<\/p>\n

\u5bf995\u4f8b\u5177\u6709\u53ef\u5206\u6790\u6837\u672c\u7684\u60a3\u8005\u8fdb\u884c\u7a81\u53d8\u5206\u578b\uff0c\u53d1\u73b0Y537S\u7a81\u53d8\u662f\u6700\u5e38\u89c1\u7684\u7a81\u53d8\uff08N=36\uff0c37.9%\uff09\uff0c\u5728bESR1\u7a81\u53d8\u6c34\u5e73\u4e0a\u5347\u548c\u8fdb\u5c55\u65f6\uff0c\u5206\u522b\u6709N=25\uff0826.3%\uff09\u548cN=18\uff0869.2%\uff09\u5b58\u5728\u591a\u514b\u9686bESR1\u7a81\u53d8\u3002\u7a81\u53d8\u7c7b\u578b\uff08\u5305\u62ec Y537S\uff09\u548cbESR1mut\u5347\u9ad8\u65f6\u591a\u514b\u9686 bESR1mut \u7684\u5b58\u5728\u4e0d\u5f71\u54cd\u60a3\u8005\u7684\u751f\u5b58\u7387\u548c\u7ec4\u95f4\u98ce\u9669\u6bd4\u3002<\/p>\n

  \u7814\u7a76\u7ed3\u8bba  <\/p>\n

bESR1mut ctDNA\u52a8\u529b\u5b66\u652f\u6301\u5728\u51fa\u73b0bESR1mut\u5347\u9ad8\u540e\u5c06\u60a3\u8005\u6cbb\u7597\u65b9\u6848\u66f4\u6539\u4e3a\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u54cc\u67cf\u897f\u5229\u7684\u4e34\u5e8a\u83b7\u76ca\u4f18\u4e8e\u7ee7\u7eed\u63a5\u53d7AI\u8054\u5408\u54cc\u67cf\u897f\u5229\u3002ESR1\u7a81\u53d8\u7c7b\u578b\u548c\u514b\u9686\u6027\u5e76\u4e0d\u5f71\u54cd\u6cbb\u7597\u65b9\u6848\u6539\u53d8\u7684\u76ca\u5904\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/p>\n

1002-Dynamics and type of ESR1 mutations under aromatase inhibitor or fulvestrant combined with palbociclib after randomization in the PADA-1 trial.<\/p>\n

\u8d23\u4efb\u7f16\u8f91 | Meguro<\/p>\n","protected":false},"excerpt":{"rendered":"

  \u524d\u8a00 PADA-1 \u662f\u7b2c\u4e00\u4e2a\u63a2\u8ba8\u5982\u4f55\u5229\u7528\u8840\u6db2\u4e2dESR1 \u7a81\u53d8 \uff08b … \u7ee7\u7eed\u9605\u8bfb →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-41610","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/41610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41610"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/41610\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=41610"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=41610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}