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1 \u80a0\u9053\u83cc\u7fa4\u4e0e\u813e\u529f\u80fd\u76f8\u5173<\/h2>\n

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2 \u5065\u813e\u7c7b\u4e2d\u836f\u591a\u7cd6\u8c03\u8282\u80a0\u9053\u83cc\u7fa4<\/h2>\n

2.1 \u6e83\u75a1\u6027\u7ed3\u80a0\u708e<\/h3>\n

UC\u662f\u4e00\u79cd\u5f25\u6f2b\u6027\u975e\u7279\u5f02\u6027\u708e\u75c7\u6027\u75be\u75c5\uff0c\u901a\u5e38\u7d2f\u53ca\u5927\u80a0\uff0c\u51fa\u73b0\u8113\u8840\u4fbf\u3001\u8179\u75db\u3001\u91cc\u6025\u540e\u91cd\u7b49\u3002\u73b0\u4ee3\u4e2d\u533b\u591a\u5c06\u5176\u5f52\u5c5e\u4e8e\u201c\u80a0\u98ce\u201d\u201c\u80a0\u6fbc\u201d\u201c\u4e45\u75e2\u201d\u7b49\u8303\u7574\uff0c\u591a\u7531\u813e\u80c3\u865a\u5f31\u3001\u5916\u611f\u65f6\u90aa\u6c14\u3001\u996e\u98df\u4e0d\u5f53\u7b49\u56e0\u7d20\u6240\u81f4\u3002\u6881\u91d1\u82b1\u7b49\u91c7\u7528 2,4,6-\u4e09\u785d\u57fa\u82ef\u78fa\u9178\uff08TNBS\uff09\/\u4e59\u9187\u6db2\u6cd5\u5efa\u7acbUC\u5927\u9f20\u6a21\u578b\uff0c\u5e76\u4f7f\u7528\u542b\u539f\u836f\u67500.2 g\/mL\u7684\u9ec4\u82aa\u591a\u7cd6\u5e72\u9884\u6cbb\u75977 d\uff0c\u68c0\u6d4b\u53d1\u73b0\u5927\u9f20\u76f2\u80a0\u5185\u53cc\u6b67\u6746\u83cc\u3001\u4e73\u9178\u6746\u83cc\u6570\u91cf\u5347\u9ad8\uff0c\u80a0\u6746\u83cc\u3001\u80a0\u7403\u83cc\u6570\u91cf\u964d\u4f4e\uff0c\u83cc\u7fa4\u6bd4\u4f8b\u6062\u590d\u6b63\u5e38\uff0c\u538c\u6c27\u83cc\u4ee3\u8c22\u4ea7\u7269\u4e59\u9178\u542b\u91cf\u4e0b\u964d\uff0c\u4e14\u809d\u810f\u7ec6\u83cc\u6613\u4f4d\u6570\u91cf\u663e\u8457\u4e0b\u964d\uff0c\u7ec6\u83cc\u6613\u4f4d\u5f97\u5230\u63a7\u5236\uff0c\u6700\u7ec8\u4f5c\u7528\u6548\u679c\u4f18\u4e8e\u53cc\u6b67\u6746\u83cc\u6d3b\u83cc\u80f6\u56ca\u3002\u9648\u65b0\u541b\u4f7f\u7528\u542b\u539f\u836f\u67500.5 g\/mL\u7684\u515a\u53c2\u591a\u7cd6\u5bf9\u8461\u805a\u7cd6\u786b\u9178\u94a0\uff08DSS\uff09\u8bf1\u5bfc\u7684\u6025\u6027UC\u5c0f\u9f20\u8fdb\u884c\u5e72\u988421 d\uff0c\u7ed3\u679c\u53d1\u73b0\uff0c\u6a21\u578b\u5c0f\u9f20\u7ed3\u80a0\u7ec4\u7ec7\u7ed3\u6784\u635f\u4f24\u660e\u663e\u6539\u5584\uff0c\u4e14\u515a\u53c2\u591a\u7cd6\u80fd\u4fc3\u8fdb\u53cc\u6b67\u6746\u83cc\u5c5e\u3001\u4e73\u6746\u83cc\u5c5e\u7b49\u5e38\u89c1\u76ca\u751f\u83cc\u589e\u6b96\uff0c\u5177\u6709\u4f5c\u4e3a\u76ca\u751f\u5143\u7684\u6f5c\u529b\u3002\u540c\u65f6\uff0c\u7531\u4e8eSCFA\u51b3\u5b9a\u80a0\u9ecf\u819c\u5c4f\u969c\u7684\u901a\u900f\u6027\uff0c\u4e0e\u75be\u75c5\u7684\u75c5\u7a0b\u53ca\u6d3b\u8dc3\u5ea6\u5bc6\u5207\u76f8\u5173\uff0c\u53d1\u73b0\u515a\u53c2\u591a\u7cd6\u7ec4\u6709\u666e\u6c0f\u83cc\u5c5e\u3001\u7caa\u6746\u83cc\u5c5e\u3001\u7f55\u89c1\u5c0f\u7403\u83cc\u5c5e\u7b497\u79cd\u83cc\u5c5e\u4e0e\u6539\u5584SCFA\u4ea7\u751f\u76f8\u5173\uff0c\u53ef\u660e\u663e\u88ab\u5176\u5bcc\u96c6\uff0c\u8868\u660e\u515a\u53c2\u591a\u7cd6\u5177\u6709\u6539\u5584\u80a0\u9053\u5fae\u751f\u6001\uff0c\u4ece\u800c\u8c03\u8282\u80a0\u9053\u5f02\u5e38\u75c5\u7406\u72b6\u6001\u7684\u80fd\u529b\uff0c\u8ba4\u4e3a\u53ef\u80fd\u662f\u56db\u541b\u5b50\u6c64\u53d1\u6325\u4f5c\u7528\u7684\u7269\u8d28\u57fa\u7840\uff0c\u6709\u8f83\u597d\u7684\u5e94\u7528\u524d\u666f\u3002Jing\u7b49\u89c2\u5bdf\u515a\u53c2\u591a\u7cd6\u5bf9DSS\u8bf1\u5bfc\u7684\u6025\u6027UC\u5c0f\u9f20\u5f71\u54cd\u53d1\u73b0\uff0c\u515a\u53c2\u591a\u7cd6\u901a\u8fc7\u4fc3\u8fdb\u53cc\u6b67\u6746\u83cc\u3001\u4e73\u9178\u6746\u83cc\u3001\u514b\u6c0f\u6746\u83cc3\u79cd\u91cd\u8981\u76ca\u751f\u83cc\u751f\u957f\uff0c\u6291\u5236\u8131\u786b\u5f27\u83cc\u3001\u94fe\u9709\u83cc\u548c\u5e7d\u95e8\u87ba\u6746\u83cc\u5bfc\u81f4\u75c5\u83cc\u751f\u957f\uff0c\u53d1\u6325\u76ca\u751f\u83cc\u4f5c\u7528\u3002Xie\u7b49\u4f7f\u7528\u542b\u7075\u829d\u591a\u7cd6\u7684\u7279\u5236\u9972\u6599\u5bf9DSS\u8bf1\u5bfc\u7684UC\u5927\u9f20\u8fdb\u884c\u5e72\u9884\u53d1\u73b0\uff0c\u6444\u5165\u7075\u829d\u591a\u7cd6\u5bf9\u80a0\u9053\u83cc\u7fa4\u6709\u660e\u663e\u8c03\u8282\u4f5c\u7528\uff0c\u53ef\u589e\u52a0 SCFAs\u7684\u4ea7\u751f\u83cc\uff0c\u51cf\u5c11\u5927\u80a0\u6746\u83cc\uff0c\u5e76\u8c03\u8282\u708e\u75c7\u76f8\u5173\u57fa\u56e0\u3002Shao\u7b49\u53d1\u73b0\uff0c1.2 g\/kg\u7334\u5934\u83c7\u591a\u7cd6EP-1\u53ef\u8c03\u8282\u4e59\u9178\u8bf1\u5bfc\u7684UC\u5927\u9f20\u80a0\u9053\u83cc\u7fa4\uff0c\u589e\u52a0SCFA\u542b\u91cf\uff0c\u4e14\u7ed3\u80a0\u7ec4\u7ec7G\u86cb\u767d\u5076\u8054\u53d7\u4f53GPR41\u548cGPR43\u8868\u8fbe\u660e\u663e\u88ab\u6291\u5236\uff0c\u8868\u73b0\u51fa\u6297\u6c27\u5316\u3001\u6297\u708e\u548c\u589e\u5f3a\u514d\u75ab\u6d3b\u6027\u4f5c\u7528\uff0c\u63d0\u793a\u7334\u5934\u83c7\u591a\u7cd6EP-1\u662f\u7334\u5934\u83c7\u53d1\u6325\u6297UC\u4f5c\u7528\u7684\u6d3b\u6027\u6210\u5206\uff0c\u5177\u6709\u8865\u5145\u548c\u66ff\u4ee3\u4f20\u7edf\u8349\u836f\u7597\u6cd5\u7684\u6f5c\u529b\u3002\u97e9\u4f1f\u4e1c\u7b49\u4ee5\u9999\u83c7\u591a\u7cd6\u704c\u80c3\u5e72\u9884\u76d0\u9178\u6797\u53ef\u9709\u7d20\u8bf1\u5bfc\u7684UC\u5927\u9f20\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u9999\u83c7\u591a\u7cd6\u53ef\u4fc3\u8fdb\u53cc\u6b67\u6746\u83cc\u4e0e\u4e73\u9178\u6746\u83cc\u751f\u957f\uff0c\u6291\u5236\u80a0\u6746\u83cc\u4e0e\u80a0\u7403\u83cc\u589e\u6b96\uff0c\u663e\u8457\u5347\u9ad8\u80a0\u5185\u5bb9\u7269\u6325\u53d1\u6027\u8102\u80aa\u9178\uff08\u4e59\u9178\u3001\u4e19\u9178\u3001\u4e01\u9178\uff09\u542b\u91cf\uff0c\u964d\u4f4e\u8840\u4e2d\u5185\u6bd2\u7d20\u542b\u91cf\uff0c\u4e14\u4e0e\u53cc\u6b67\u6746\u83cc\u6d3b\u83cc\u80f6\u56ca\u8054\u5408\u7528\u836f\u540e\uff0c\u66f4\u80fd\u53d1\u6325\u4f5c\u4e3a\u80a0\u9053\u76ca\u751f\u5143\u7684\u4f5c\u7528\u3002\u53ef\u89c1\uff0c\u9ec4\u82aa\u3001\u515a\u53c2\u3001\u7075\u829d\u7b49\u5065\u813e\u7c7b\u4e2d\u836f\u591a\u7cd6\u6297UC\u4f5c\u7528\u660e\u663e\uff0c\u751a\u81f3\u53ef\u80fd\u662f\u590d\u65b9\u6216\u539f\u836f\u6750\u53d1\u6325\u529f\u6548\u7684\u4e3b\u8981\u7269\u8d28\u57fa\u7840\u3002<\/p>\n

2.2 \u7cd6\u5c3f\u75c5<\/h3>\n

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mg\/kg\u5c71\u836f\u591a\u7cd6\u5bf9\u80a5\u80d6\u7cd6\u5c3f\u75c5\u80be\u75c5\u5927\u9f20\u704c\u80c3\u5e72\u988430 d\u540e\u53d1\u73b0\uff0c\u5c71\u836f\u591a\u7cd6\u53ef\u964d\u4f4e\u80a0\u9053\u5185\u62df\u6746\u83cc\u5c5e\u3001\u57c3\u5e0c\u83cc\u5c5e\u3001\u5fd7\u8d3a\u83cc\u5c5e\u3001\u6c99\u95e8\u83cc\u5c5e\u7b49\u6709\u5bb3\u83cc\u6570\u91cf\uff0c\u540c\u65f6\u6539\u5584\u7cd6\u5c3f\u75c5\u5927\u9f20\u80be\u529f\u80fd\u3002\u7530\u4e3d\u7814\u7a76\u53d1\u73b0\uff0c200 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mg\/kg\u858f\u82e1\u4ec1\u591a\u7cd6\u5bf9\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u8840\u7cd6\u548c\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u5f71\u54cd\uff0c\u53d1\u73b0\u858f\u82e1\u4ec1\u591a\u7cd6\u5e72\u98844\u5468\u540e\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u8840\u7cd6\u3001\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u3001\u603b\u80c6\u56fa\u9187\u3001\u4e09\u9170\u7518\u6cb9\u3001\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u6c34\u5e73\u663e\u8457\u964d\u4f4e\uff0c\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd\u53ca\u4e73\u9178\u6746\u83cc\u5c5e\u7684\u76f8\u5bf9\u4e30\u5ea6\u663e\u8457\u589e\u52a0\uff0c\u5e76\u51cf\u5c11\u62df\u6746\u83cc\u6570\u91cf\uff0c\u8ba4\u4e3a\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u53ef\u80fd\u662f\u858f\u82e1\u4ec1\u591a\u7cd6\u4e3b\u8981\u836f\u7406\u5b66\u9776\u70b9\u3002\u4e01\u7fd8\u89c2\u5bdf25\u300150\u3001100 mg\/kg\u9ed1\u7075\u829d\u591a\u7cd6\u5bf9\u7cd6\u5c3f\u75c5\u5927\u9f20\u7684\u5f71\u54cd\u53d1\u73b0\uff0c\u80a0\u9053\u6709\u76ca\u83cc\u4e0e\u6709\u5bb3\u83cc\u7684\u7ec4\u6210\u548c\u7ed3\u6784\u53d1\u751f\u663e\u8457\u53d8\u5316\uff0c\u9ed1\u7075\u829d\u591a\u7cd6\u53ef\u8c03\u63a7\u5982\u805a\u7cd6\u751f\u7269\u5408\u6210\u548c\u4ee3\u8c22\u3001\u5149\u5408\u6210\u86cb\u767d\u7b49\u591a\u6761\u901a\u8def\uff0c\u4ece\u800c\u7f13\u89e3\u7cd6\u5c3f\u75c5\u3002Chen\u7b49\u4ee5400 mg\/kg\u7075\u829d\u591a\u7cd6\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u5927\u9f20\uff0c\u53d1\u73b0\u7075\u829d\u591a\u7cd6\u5bf9\u80a0\u9053\u83cc\u7fa4\u6709\u826f\u597d\u7684\u6539\u5584\u4f5c\u7528\uff0c\u53ef\u964d\u4f4e\u6c14\u7403\u83cc\u3001\u7624\u80c3\u7403\u83cc\u3001\u68d2\u72b6\u6746\u83cc\u548c\u53d8\u5f62\u6746\u83cc\u7b49\u6709\u5bb3\u83cc\u4e30\u5ea6\uff0c\u63d0\u9ad8\u84dd\u85fb\u3001\u8131\u76d0\u6746\u83cc\u3001\u7c7b\u526f\u6746\u83cc\u548c\u7c7b\u6746\u83cc\u6570\u91cf\uff0c\u5e76\u6539\u5584\u5927\u9f20\u80a0\u9053\u83cc\u7fa4\u7684\u6c28\u57fa\u9178\u3001\u78b3\u6c34\u5316\u5408\u7269\u3001\u708e\u75c7\u7269\u8d28\u3001\u6838\u9178\u4ee3\u8c22\u3002<\/p>\n

2.3 \u80a5\u80d6<\/h3>\n

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3 \u5c55\u671b<\/h2>\n

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\u968f\u7740\u4e2d\u836f\u591a\u7cd6\u53ef\u4f5c\u4e3a\u6f5c\u5728\u76ca\u751f\u5143\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\u7684\u76f8\u5173\u7814\u7a76\u9010\u6e10\u6df1\u5165\uff0c\u5176\u5728\u6539\u5584\u813e\u865a\u65b9\u9762\u5c06\u53d1\u6325\u66f4\u91cd\u8981\u7684\u4f5c\u7528\u3002\u5efa\u8bae\u5c06\u8be5\u7c7b\u5236\u5242\u7528\u4e8e\u4e34\u5e8a\uff0c\u901a\u8fc7\u5229\u7528\u4e0d\u540c\u4e2d\u836f\u591a\u7cd6\u9009\u62e9\u6027\u4f5c\u7528\u6216\u9776\u5411\u6027\u8c03\u8282\u4f53\u5185\u80a0\u9053\u83cc\u79cd\uff0c\u6269\u5927\u4e2d\u836f\u591a\u7cd6\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\u6539\u5584\u813e\u865a\u75c7\u72b6\u7684\u8303\u56f4\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u76f8\u5e94\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

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