{"id":41340,"date":"2024-09-24T05:10:25","date_gmt":"2024-09-24T05:10:25","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=41340"},"modified":"2024-09-24T05:10:25","modified_gmt":"2024-09-24T05:10:25","slug":"%e9%80%86%e8%bd%ac90%e6%85%a2%e6%80%a7%e7%97%85-%e5%90%83%e5%af%b9%e4%b8%89%e5%a4%a7%e5%85%b3%e9%94%ae-%e4%bf%ae%e5%a4%8d%e7%ba%bf%e7%b2%92%e4%bd%93","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=41340","title":{"rendered":"\u9006\u8f6c90%\u6162\u6027\u75c5: \u5403\u5bf9\u4e09\u5927\u5173\u952e 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Silencing\u201d\u3002\u8fd9\u4e0d\u4ec5\u9002\u7528\u4e8e\u4ed6\u81ea\u5df1\uff0c\u4e5f\u53ef\u80fd\u5e2e\u52a9\u65e0\u6570\u540c\u6837\u906d\u53d7\u7cd6\u5c3f\u75c5\u5a01\u80c1\u7684\u4eba\u3002<\/p>\n<p>\u5728\u7f8e\u56fd\uff0c\u9648\u533b\u5e08\u83b7\u5f97\u4e86\u533b\u5e08\u6267\u7167\uff0c\u5f00\u8bbe\u4e86\u81ea\u5df1\u7684\u8bca\u6240\u3002\u4ed6\u7684\u6cbb\u7597\u65b9\u6cd5\u7ed3\u5408\u4e86\u73b0\u4ee3\u533b\u5b66\u548c\u81ea\u7136\u7597\u6cd5\uff0c\u6210\u4e3a\u4e86\u8bb8\u591a\u75c5\u60a3\u7684\u5e0c\u671b\u3002\u800c\u4ed6\u5bf9\u6297\u7cd6\u5c3f\u75c5\u7684\u6545\u4e8b\uff0c\u4e5f\u6b63\u5728\u6fc0\u52b1\u7740\u8d8a\u6765\u8d8a\u591a\u7684\u4eba\u6539\u53d8\u751f\u6d3b\u65b9\u5f0f\uff0c\u62e5\u62b1\u5065\u5eb7\u3002<\/p>\n<p>\u201c\u4e0d\u8981\u602a\u7f6a\u57fa\u56e0\uff0c\u4e0a\u5929\u7ed9\u7684\u90fd\u662f\u597d\u7684\u3002\u201d\u9648\u533b\u5e08\u5e38\u8fd9\u4e48\u8bf4\u3002<\/p>\n<p>\u76f8\u4fe1\u60a8\u770b\u5b8c\u4e0b\u9762\u8fd9\u6761\u89c6\u9891\uff0c\u60a8\u7684\u996e\u98df\u89c2\u5ff5\u4f1a\u5927\u5e45\u9769\u65b0\uff0c\u5728\u751f\u6d3b\u4e2d\u8fd8\u80fd\u627e\u5230\u8bb8\u591a\u53ef\u4ee5\u5b9e\u8df5\u7684\u65b9\u6cd5\uff01                             <\/p>\n<p>\u4ec0\u4e48\u662f\u7ebf\u7c92\u4f53\uff1f<\/p>\n<p>\u7ebf\u7c92\u4f53\uff08mitochondria\uff09\uff0c\u53f0\u6e7e\u7701\u79f0\u4e3a\u201c\u7c92\u7ebf\u4f53\u201d\uff0c\u662f\u6211\u4eec\u7ec6\u80de\u4e2d\u7684\u4e00\u79cd\u91cd\u8981\u7ed3\u6784\uff0c\u5e38\u88ab\u79f0\u4e3a\u7ec6\u80de\u7684\u201c\u52a8\u529b\u5de5\u5382\u201d\u3002\u5b83\u4eec\u7684\u4e3b\u8981\u4f5c\u7528\u662f\u901a\u8fc7\u4e00\u79cd\u53eb\u505a\u201c\u7ec6\u80de\u547c\u5438\u201d\u7684\u8fc7\u7a0b\u5c06\u98df\u7269\u4e2d\u7684\u80fd\u91cf\u8f6c\u5316\u4e3a\u7ec6\u80de\u53ef\u4ee5\u4f7f\u7528\u7684\u80fd\u91cf\u5f62\u5f0f\u2014\u2014\u4e09\u78f7\u9178\u817a\u82f7\uff08ATP\uff09\u3002\u7b80\u800c\u8a00\u4e4b\uff0c\u7ebf\u7c92\u4f53\u5e2e\u52a9\u6211\u4eec\u4ece\u98df\u7269\u4e2d\u83b7\u5f97\u80fd\u91cf\uff0c\u7ef4\u6301\u8eab\u4f53\u7684\u6b63\u5e38\u8fd0\u8f6c\u3002<\/p>\n<h3>\u7ebf\u7c92\u4f53\u4e0e\u75be\u75c5\u7684\u5173\u7cfb<\/h3>\n<p>\u7ebf\u7c92\u4f53\u5728\u6211\u4eec\u7684\u8eab\u4f53\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u7684\u89d2\u8272\uff0c\u56e0\u6b64\uff0c\u5f53\u5b83\u4eec\u51fa\u73b0\u95ee\u9898\u65f6\uff0c\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4e00\u7cfb\u5217\u5065\u5eb7\u95ee\u9898\uff0c\u5c24\u5176\u662f\u4ee5\u4e0b\u51e0\u7c7b\u75be\u75c5\uff1a<\/p>\n<h4>1. \u8111\u90e8\u75be\u75c5<\/h4>\n<p>\u5927\u8111\u662f\u6211\u4eec\u8eab\u4f53\u4e2d\u80fd\u91cf\u9700\u6c42\u6700\u9ad8\u7684\u5668\u5b98\u4e4b\u4e00\uff0c\u56e0\u6b64\uff0c\u7ebf\u7c92\u4f53\u529f\u80fd\u7684\u5f02\u5e38\u4f1a\u4e25\u91cd\u5f71\u54cd\u5927\u8111\u7684\u5065\u5eb7\u3002\u4f8b\u5982\uff1a<\/p>\n<ul>\n<li>\n<p>\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff1a\u7814\u7a76\u8868\u660e\uff0c\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u53ef\u80fd\u4e0e\u8fd9\u79cd\u8001\u5e74\u75f4\u5446\u75c7\u6709\u5173\uff0c\u7ebf\u7c92\u4f53\u635f\u4f24\u4f1a\u5bfc\u81f4\u8111\u7ec6\u80de\u7684\u80fd\u91cf\u4f9b\u5e94\u4e0d\u8db3\uff0c\u52a0\u901f\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n<\/li>\n<li>\n<p>\u5e15\u91d1\u68ee\u75c5\uff1a\u8fd9\u662f\u4e00\u79cd\u5f71\u54cd\u8fd0\u52a8\u63a7\u5236\u7684\u75be\u75c5\uff0c\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u53ef\u80fd\u5bfc\u81f4\u591a\u5df4\u80fa\u795e\u7ecf\u5143\u7684\u6b7b\u4ea1\uff0c\u8fd9\u4e9b\u795e\u7ecf\u5143\u5bf9\u4e8e\u8fd0\u52a8\u63a7\u5236\u975e\u5e38\u91cd\u8981\u3002<\/p>\n<\/li>\n<\/ul>\n<h4>2. \u809d\u810f\u75be\u75c5<\/h4>\n<p>\u809d\u810f\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u89e3\u6bd2\u548c\u4ee3\u8c22\u5668\u5b98\uff0c\u7ebf\u7c92\u4f53\u5728\u809d\u810f\u4e2d\u4e5f\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u4f8b\u5982\uff1a<\/p>\n<ul>\n<li>\n<p>\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u75c5\uff08NAFLD\uff09\uff1a\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u53ef\u80fd\u5bfc\u81f4\u8102\u80aa\u5728\u809d\u810f\u4e2d\u7684\u5f02\u5e38\u5806\u79ef\uff0c\u8fdb\u4e00\u6b65\u5f15\u53d1\u809d\u708e\u3001\u809d\u786c\u5316\u7b49\u4e25\u91cd\u75be\u75c5\u3002<\/p>\n<\/li>\n<li>\n<p>\u9152\u7cbe\u6027\u809d\u75c5\uff08ALD\uff09\uff1a\u8fc7\u91cf\u996e\u9152\u4f1a\u635f\u4f24\u7ebf\u7c92\u4f53\uff0c\u4f7f\u809d\u7ec6\u80de\u96be\u4ee5\u89e3\u6bd2\u548c\u4fee\u590d\uff0c\u5bfc\u81f4\u809d\u529f\u80fd\u4e0b\u964d\u3002<\/p>\n<\/li>\n<\/ul>\n<h4>3. \u4ee3\u8c22\u75be\u75c5<\/h4>\n<p>\u7ebf\u7c92\u4f53\u5728\u80fd\u91cf\u4ee3\u8c22\u4e2d\u8d77\u7740\u6838\u5fc3\u4f5c\u7528\uff0c\u56e0\u6b64\uff0c\u4e0e\u4ee3\u8c22\u76f8\u5173\u7684\u75be\u75c5\u4e5f\u4e0e\u7ebf\u7c92\u4f53\u5bc6\u5207\u76f8\u5173\u3002\u4f8b\u5982\uff1a<\/p>\n<ul>\n<li>\n<p>2\u578b\u7cd6\u5c3f\u75c5\uff1a\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u53ef\u80fd\u5bfc\u81f4\u80f0\u5c9b\u7d20\u62b5\u6297\u548c\u8840\u7cd6\u8c03\u8282\u80fd\u529b\u4e0b\u964d\uff0c\u8fd9\u4e9b\u90fd\u662f2\u578b\u7cd6\u5c3f\u75c5\u7684\u91cd\u8981\u7279\u5f81\u3002<\/p>\n<\/li>\n<li>\n<p>\u80a5\u80d6\uff1a\u7ebf\u7c92\u4f53\u529f\u80fd\u51cf\u5f31\u4f1a\u5bfc\u81f4\u8eab\u4f53\u71c3\u70e7\u80fd\u91cf\u7684\u6548\u7387\u4e0b\u964d\uff0c\u4fc3\u8fdb\u8102\u80aa\u5806\u79ef\uff0c\u5bfc\u81f4\u80a5\u80d6\u3002<\/p>\n<\/li>\n<\/ul>\n<p>\u7ebf\u7c92\u4f53\u4f5c\u4e3a\u7ec6\u80de\u7684\u52a8\u529b\u5de5\u5382\uff0c\u5bf9\u6211\u4eec\u7684\u5065\u5eb7\u81f3\u5173\u91cd\u8981\u3002\u5f53\u7ebf\u7c92\u4f53\u51fa\u73b0\u95ee\u9898\u65f6\uff0c\u4f1a\u5f71\u54cd\u80fd\u91cf\u4f9b\u5e94\uff0c\u8fdb\u800c\u5bfc\u81f4\u4e00\u7cfb\u5217\u75be\u75c5\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u9ad8\u80fd\u91cf\u9700\u6c42\u7684\u5668\u5b98\uff0c\u5982\u5927\u8111\u548c\u809d\u810f\u3002\u56e0\u6b64\uff0c\u4fdd\u6301\u7ebf\u7c92\u4f53\u7684\u5065\u5eb7\u529f\u80fd\uff0c\u5bf9\u4e8e\u9884\u9632\u548c\u6cbb\u7597\u8fd9\u4e9b\u75be\u75c5\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n<h3>\u7ebf\u7c92\u4f53\u4e0e\u9ad8\u78b3\u6c34\u5316\u5408\u7269\u7684\u5173\u7cfb<\/h3>\n<p>\u7ebf\u7c92\u4f53\u4f5c\u4e3a\u7ec6\u80de\u4e2d\u7684\u201c\u52a8\u529b\u5de5\u5382\u201d\uff0c\u5b83\u4eec\u901a\u8fc7\u201c\u7ec6\u80de\u547c\u5438\u201d\u5c06\u98df\u7269\u4e2d\u7684\u80fd\u91cf\u8f6c\u5316\u4e3a\u7ec6\u80de\u53ef\u4ee5\u4f7f\u7528\u7684\u80fd\u91cf\u5f62\u5f0f&#8211;ATP\u3002\u9ad8\u78b3\u6c34\u5316\u5408\u7269\u996e\u98df\uff08\u4f8b\u5982\u7c73\u996d\u3001\u9762\u6761\u3001\u9762\u5305\u7b49\uff09\u4f1a\u63d0\u4f9b\u5927\u91cf\u7684\u8461\u8404\u7cd6\uff0c\u8fd9\u4e9b\u8461\u8404\u7cd6\u8fdb\u5165\u7ec6\u80de\u540e\uff0c\u4f1a\u88ab\u7ebf\u7c92\u4f53\u7528\u6765\u751f\u4ea7ATP\u3002<\/p>\n<p>\u7136\u800c\uff0c\u5f53\u6444\u5165\u7684\u78b3\u6c34\u5316\u5408\u7269\u8fc7\u591a\u65f6\uff0c\u7ebf\u7c92\u4f53\u9700\u8981\u5904\u7406\u5927\u91cf\u7684\u8461\u8404\u7cd6\uff0c\u8fd9\u4f1a\u589e\u52a0\u5b83\u4eec\u7684\u5de5\u4f5c\u91cf\u3002\u5982\u679c\u7ebf\u7c92\u4f53\u8fc7\u5ea6\u5de5\u4f5c\uff0c\u4f1a\u4ea7\u751f\u66f4\u591a\u7684\u201c\u526f\u4ea7\u54c1\u201d&#8211;\u6d3b\u6027\u6c27\uff08ROS\uff09\u3002<\/p>\n<h3>\u7ebf\u7c92\u4f53\u4e0e\u6d3b\u6027\u6c27\uff08ROS\uff09\u7684\u5173\u7cfb<\/h3>\n<p>\u6d3b\u6027\u6c27\uff08ROS\uff09\u662f\u4e00\u79cd\u5728\u7ebf\u7c92\u4f53\u80fd\u91cf\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u526f\u4ea7\u54c1\u3002\u5c11\u91cf\u7684ROS\u5bf9\u7ec6\u80de\u662f\u6709\u76ca\u7684\uff0c\u56e0\u4e3a\u5b83\u4eec\u53ef\u4ee5\u4f5c\u4e3a\u4fe1\u53f7\u5206\u5b50\uff0c\u5e2e\u52a9\u8c03\u8282\u7ec6\u80de\u529f\u80fd\u3002\u7136\u800c\uff0c\u5f53\u6d3b\u6027\u6c27\u4ea7\u751f\u8fc7\u591a\u65f6\uff0c\u4f1a\u5bf9\u7ec6\u80de\u9020\u6210\u635f\u5bb3\uff0c\u5bfc\u81f4\u6c27\u5316\u5e94\u6fc0\u3002<\/p>\n<p>\u6c27\u5316\u5e94\u6fc0\u4f1a\u635f\u4f24\u7ec6\u80de\u819c\u3001\u86cb\u767d\u8d28\u548cDNA\uff0c\u8fdb\u800c\u5f15\u53d1\u5404\u79cd\u75be\u75c5\uff0c\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\n<p>\u708e\u75c7\uff1aROS\u8fc7\u591a\u4f1a\u5f15\u53d1\u6162\u6027\u708e\u75c7\uff0c\u5bfc\u81f4\u7ec4\u7ec7\u635f\u4f24\u3002<\/p>\n<\/li>\n<li>\n<p>\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff1a\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\uff0c\u7814\u7a76\u8868\u660e\u8fd9\u4e9b\u75be\u75c5\u4e0eROS\u5f15\u53d1\u7684\u7ec6\u80de\u635f\u4f24\u6709\u5173\u3002<\/p>\n<\/li>\n<li>\n<p>\u4ee3\u8c22\u75be\u75c5\uff1a\u5982\u7cd6\u5c3f\u75c5\uff0cROS\u8fc7\u591a\u4f1a\u635f\u4f24\u80f0\u5c9b\u7ec6\u80de\uff0c\u5f71\u54cd\u80f0\u5c9b\u7d20\u5206\u6ccc\u3002<\/p>\n<\/li>\n<\/ul>\n<p>\u7b80\u5355\u6765\u8bf4\uff0c\u9ad8\u78b3\u6c34\u5316\u5408\u7269\u996e\u98df\u4f1a\u589e\u52a0\u7ebf\u7c92\u4f53\u7684\u5de5\u4f5c\u91cf\uff0c\u5bfc\u81f4\u66f4\u591a\u7684ROS\u4ea7\u751f\u3002\u5f53ROS\u8fc7\u591a\u65f6\uff0c\u4f1a\u5f15\u53d1\u6c27\u5316\u5e94\u6fc0\uff0c\u635f\u4f24\u7ec6\u80de\uff0c\u8fdb\u800c\u5bfc\u81f4\u5404\u79cd\u75be\u75c5\u3002\u56e0\u6b64\uff0c\u4fdd\u6301\u9002\u91cf\u7684\u78b3\u6c34\u5316\u5408\u7269\u6444\u5165\uff0c\u5e76\u901a\u8fc7\u6297\u6c27\u5316\u5242\uff08\u5982\u7ef4\u751f\u7d20C\u3001\u7ef4\u751f\u7d20E\uff09\u6765\u4e2d\u548cROS\uff0c\u53ef\u4ee5\u5e2e\u52a9\u4fdd\u62a4\u7ebf\u7c92\u4f53\uff0c\u7ef4\u6301\u8eab\u4f53\u5065\u5eb7\u3002<\/p>\n<h3>\u4ec0\u4e48\u662f\u201c\u51c0\u78b3\u201d\uff1f<\/h3>\n<p>\u51c0\u78b3\uff08Net Carbs\uff09\u662f\u6307\u603b\u78b3\u6c34\u5316\u5408\u7269\u4e2d\u51cf\u53bb\u7ea4\u7ef4\u548c\u7cd6\u9187\u540e\u7684\u53ef\u6d88\u5316\u78b3\u6c34\u5316\u5408\u7269\u91cf\u3002\u5b83\u8868\u793a\u90a3\u4e9b\u4f1a\u5bf9\u8840\u7cd6\u6c34\u5e73\u4ea7\u751f\u76f4\u63a5\u5f71\u54cd\u7684\u78b3\u6c34\u5316\u5408\u7269\u542b\u91cf\u3002\u8ba1\u7b97\u51c0\u78b3\u7684\u65b9\u6cd5\u662f\uff1a<\/p>\n<p>\u51c0\u78b3=\u603b\u78b3\u6c34\u5316\u5408\u7269\u2212\u81b3\u98df\u7ea4\u7ef4\u2212\u7cd6\u9187<\/p>\n<p>\u8fd9\u79cd\u8ba1\u7b97\u65b9\u6cd5\u5f88\u91cd\u8981\uff0c\u56e0\u4e3a\u7ea4\u7ef4\u548c\u4e00\u4e9b\u7cd6\u9187\uff08\u5982\u6728\u7cd6\u9187\u3001\u9ea6\u82bd\u7cd6\u9187\uff09\u4e0d\u4f1a\u663e\u8457\u5f71\u54cd\u8840\u7cd6\u6c34\u5e73\uff0c\u5b83\u4eec\u5728\u4eba\u4f53\u5185\u7684\u6d88\u5316\u548c\u5438\u6536\u8fc7\u7a0b\u4e0d\u540c\u4e8e\u5176\u4ed6\u78b3\u6c34\u5316\u5408\u7269\u3002<\/p>\n<h3>\u201c\u51c0\u78b350\u201d\u996e\u98df\u65b9\u6848<\/h3>\n<p>\u51c0\u78b350\u662f\u4e00\u79cd\u996e\u98df\u7b56\u7565\uff0c\u901a\u5e38\u7528\u4e8e\u4f4e\u78b3\u6c34\u5316\u5408\u7269\u996e\u98df\u6216\u751f\u916e\u996e\u98df\u3002\u5b83\u7684\u57fa\u672c\u539f\u5219\u662f\u6bcf\u5929\u6444\u5165\u7684\u51c0\u78b3\u6c34\u5316\u5408\u7269\u4e0d\u8d85\u8fc750\u514b\u3002\u8fd9\u79cd\u996e\u98df\u65b9\u5f0f\u6709\u52a9\u4e8e\u51cf\u5c11\u8840\u7cd6\u6ce2\u52a8\u548c\u80f0\u5c9b\u7d20\u5206\u6ccc\uff0c\u4ece\u800c\u5e2e\u52a9\u63a7\u5236\u4f53\u91cd\u548c\u7ba1\u7406\u8840\u7cd6\u6c34\u5e73\u3002<\/p>\n<p>\u4ee5\u4e0b\u662f\u51c0\u78b350\u996e\u98df\u7684\u4e00\u4e9b\u8981\u70b9\uff1a<\/p>\n<h4>1. \u9009\u62e9\u4f4e\u51c0\u78b3\u98df\u7269<\/h4>\n<ul>\n<li>\n<p>\u9ad8\u7ea4\u7ef4\u852c\u83dc\uff1a\u5982\u83e0\u83dc\u3001\u897f\u5170\u82b1\u3001\u82b1\u6930\u83dc\u7b49\u3002<\/p>\n<\/li>\n<li>\n<p>\u86cb\u767d\u8d28\u6765\u6e90\uff1a\u5982\u9e21\u86cb\u3001\u9c7c\u3001\u8089\u7c7b\u7b49\uff0c\u4e0d\u542b\u78b3\u6c34\u5316\u5408\u7269\u6216\u542b\u91cf\u6781\u4f4e\u3002<\/p>\n<\/li>\n<li>\n<p>\u5065\u5eb7\u8102\u80aa\uff1a\u5982\u6a44\u6984\u6cb9\u3001\u9cc4\u68a8\u3001\u575a\u679c\u7b49\u3002<\/p>\n<\/li>\n<\/ul>\n<h4>2. \u63a7\u5236\u78b3\u6c34\u5316\u5408\u7269\u6444\u5165<\/h4>\n<ul>\n<li>\n<p>\u907f\u514d\u9ad8\u78b3\u6c34\u5316\u5408\u7269\u98df\u7269\uff1a\u5982\u7c73\u996d\u3001\u9762\u5305\u3001\u9762\u6761\u7b49\u3002<\/p>\n<\/li>\n<li>\n<p>\u9002\u91cf\u6c34\u679c\uff1a\u9009\u62e9\u542b\u7cd6\u91cf\u4f4e\u7684\u6c34\u679c\uff0c\u5982\u6d46\u679c\uff0c\u4f46\u8981\u6ce8\u610f\u603b\u91cf\u3002<\/p>\n<\/li>\n<\/ul>\n<h4>3. \u76d1\u6d4b\u51c0\u78b3\u6444\u5165<\/h4>\n<ul>\n<li>\n<p>\u9605\u8bfb\u98df\u54c1\u6807\u7b7e\uff1a\u6ce8\u610f\u603b\u78b3\u6c34\u5316\u5408\u7269\u3001\u7ea4\u7ef4\u548c\u7cd6\u9187\u7684\u542b\u91cf\u3002<\/p>\n<\/li>\n<li>\n<p>\u8bb0\u5f55\u6bcf\u65e5\u6444\u5165\uff1a\u4fdd\u6301\u6bcf\u65e5\u51c0\u78b3\u6444\u5165\u91cf\u4e0d\u8d85\u8fc750\u514b\u3002<\/p>\n<\/li>\n<\/ul>\n<h3>\u51c0\u78b350\u996e\u98df\u7684\u597d\u5904<\/h3>\n<ul>\n<li>\n<p>\u7a33\u5b9a\u8840\u7cd6\uff1a\u51cf\u5c11\u8840\u7cd6\u6ce2\u52a8\uff0c\u6709\u52a9\u4e8e\u7cd6\u5c3f\u75c5\u60a3\u8005\u7ba1\u7406\u8840\u7cd6\u3002<\/p>\n<\/li>\n<li>\n<p>\u51cf\u91cd\uff1a\u4f4e\u78b3\u6c34\u5316\u5408\u7269\u996e\u98df\u6709\u52a9\u4e8e\u51cf\u5c11\u4f53\u5185\u8102\u80aa\u50a8\u5b58\u3002<\/p>\n<\/li>\n<li>\n<p>\u63d0\u9ad8\u80fd\u91cf\u6c34\u5e73\uff1a\u4e00\u4e9b\u4eba\u62a5\u544a\u79f0\u4f4e\u78b3\u6c34\u5316\u5408\u7269\u996e\u98df\u53ef\u4ee5\u63d0\u9ad8\u4ed6\u4eec\u7684\u6574\u4f53\u80fd\u91cf\u548c\u7cbe\u795e\u72b6\u6001\u3002<\/p>\n<\/li>\n<\/ul>\n<p>\u867d\u7136\u51c0\u78b350\u996e\u98df\u6709\u8bb8\u591a\u6f5c\u5728\u597d\u5904\uff0c\u4f46\u5e76\u4e0d\u9002\u5408\u6240\u6709\u4eba\u3002\u5728\u5f00\u59cb\u8fd9\u79cd\u996e\u98df\u4e4b\u524d\uff0c\u6700\u597d\u54a8\u8be2\u533b\u751f\u6216\u8425\u517b\u5e08\uff0c\u786e\u4fdd\u5b83\u9002\u5408\u4f60\u7684\u5065\u5eb7\u72b6\u51b5\u548c\u751f\u6d3b\u65b9\u5f0f\u3002\u6b64\u5916\uff0c\u6ce8\u610f\u996e\u98df\u5747\u8861\uff0c\u786e\u4fdd\u6444\u5165\u8db3\u591f\u7684\u7ef4\u751f\u7d20\u548c\u77ff\u7269\u8d28\u3002<\/p>\n<h3>\u63a5\u5730\uff0c\u5bf9\u7ebf\u7c92\u4f53\u7684\u597d\u5904<\/h3>\n<p>\u4eba\u4f53\u7535\u4f4d\u662f\u6307\u6211\u4eec\u4f53\u5185\u7684\u7535\u8377\u5206\u5e03\u3002\u4eba\u4f53\u5185\u5916\u7684\u7535\u8377\u5206\u5e03\u4e0d\u5e73\u8861\uff0c\u8fd9\u79cd\u7535\u8377\u7684\u4e0d\u5e73\u8861\u4f1a\u4ea7\u751f\u4e00\u79cd\u7535\u4f4d\u5dee\uff0c\u5c31\u50cf\u7535\u6c60\u4e24\u7aef\u7684\u7535\u538b\u4e00\u6837\u3002\u6211\u4eec\u7684\u7ec6\u80de\u819c\u5185\u5916\u4e5f\u5b58\u5728\u7535\u4f4d\u5dee\uff0c\u8fd9\u5bf9\u4e8e\u7ef4\u6301\u7ec6\u80de\u7684\u6b63\u5e38\u529f\u80fd\u975e\u5e38\u91cd\u8981\u3002<\/p>\n<p>\u63a5\u5730\uff0c\u662f\u6307\u6211\u4eec\u901a\u8fc7\u63a5\u89e6\u5730\u9762\u5c06\u8eab\u4f53\u7684\u7535\u8377\u5e73\u8861\u3002\u5927\u5730\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u7535\u5b50\u5e93\uff0c\u53ef\u4ee5\u4e2d\u548c\u4eba\u4f53\u591a\u4f59\u7684\u6b63\u7535\u8377\uff0c\u4f7f\u4f53\u5185\u7684\u7535\u8377\u8fbe\u5230\u5e73\u8861\u72b6\u6001\u3002\u63a5\u5730\u7684\u65b9\u5f0f\u53ef\u4ee5\u662f\u8d64\u811a\u8e29\u5728\u5730\u4e0a\uff0c\u6216\u8005\u4f7f\u7528\u4e13\u95e8\u7684\u63a5\u5730\u88c5\u7f6e\u3002<\/p>\n<h3>\u63a5\u5730\u5bf9\u7ebf\u7c92\u4f53\u7684\u597d\u5904<\/h3>\n<ul>\n<li>\n<p>\u51cf\u8f7b\u708e\u75c7\uff1a\u5f53\u4eba\u4f53\u63a5\u5730\u65f6\uff0c\u591a\u4f59\u7684\u6b63\u7535\u8377\u88ab\u4e2d\u548c\uff0c\u4f53\u5185\u7684\u81ea\u7531\u57fa\u6570\u91cf\u51cf\u5c11\u3002\u81ea\u7531\u57fa\u662f\u5bfc\u81f4\u708e\u75c7\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\uff0c\u51cf\u5c11\u81ea\u7531\u57fa\u53ef\u4ee5\u51cf\u8f7b\u708e\u75c7\uff0c\u4ece\u800c\u4fdd\u62a4\u7ebf\u7c92\u4f53\u514d\u53d7\u635f\u4f24\u3002<\/p>\n<\/li>\n<li>\n<p>\u6539\u5584\u7761\u7720\u8d28\u91cf\uff1a\u63a5\u5730\u53ef\u4ee5\u5e2e\u52a9\u8c03\u8282\u8eab\u4f53\u7684\u751f\u7269\u8282\u5f8b\uff0c\u4fc3\u8fdb\u892a\u9ed1\u6fc0\u7d20\u7684\u5206\u6ccc\u3002\u892a\u9ed1\u6fc0\u7d20\u662f\u4e00\u79cd\u5e2e\u52a9\u6211\u4eec\u5165\u7761\u7684\u6fc0\u7d20\uff0c\u5145\u8db3\u7684\u7761\u7720\u6709\u52a9\u4e8e\u7ebf\u7c92\u4f53\u7684\u4fee\u590d\u548c\u518d\u751f\u3002<\/p>\n<\/li>\n<li>\n<p>\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\uff1a\u63a5\u5730\u53ef\u4ee5\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\u7684\u529f\u80fd\uff0c\u4f7f\u8eab\u4f53\u66f4\u597d\u5730\u5bf9\u6297\u611f\u67d3\u548c\u75be\u75c5\u3002\u5065\u5eb7\u7684\u514d\u75ab\u7cfb\u7edf\u80fd\u66f4\u6709\u6548\u5730\u4fdd\u62a4\u7ebf\u7c92\u4f53\u4e0d\u53d7\u5916\u754c\u6709\u5bb3\u7269\u8d28\u7684\u4fb5\u5bb3\u3002<\/p>\n<\/li>\n<li>\n<p>\u589e\u52a0\u80fd\u91cf\uff1a\u901a\u8fc7\u51cf\u5c11\u708e\u75c7\u548c\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\uff0c\u63a5\u5730\u53ef\u4ee5\u5e2e\u52a9\u7ebf\u7c92\u4f53\u66f4\u9ad8\u6548\u5730\u751f\u4ea7\u80fd\u91cf\uff0c\u63d0\u5347\u6574\u4f53\u7684\u4f53\u80fd\u548c\u7cbe\u795e\u72b6\u6001\u3002<\/p>\n<\/li>\n<\/ul>\n<p>\u603b\u7684\u6765\u8bf4\uff0c\u63a5\u5730\u662f\u4e00\u79cd\u7b80\u5355\u3001\u81ea\u7136\u7684\u65b9\u6cd5\uff0c\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u8eab\u4f53\u7684\u7535\u4f4d\u6765\u4fdd\u62a4\u548c\u589e\u5f3a\u7ebf\u7c92\u4f53\u7684\u529f\u80fd\uff0c\u8fdb\u800c\u63d0\u9ad8\u6211\u4eec\u7684\u5065\u5eb7\u6c34\u5e73\u3002\u5373\u4f7f\u662f\u6bcf\u5929\u82b1\u4e00\u70b9\u65f6\u95f4\u63a5\u5730\uff0c\u4e5f\u80fd\u5bf9\u6211\u4eec\u7684\u8eab\u4f53\u4ea7\u751f\u79ef\u6781\u7684\u5f71\u54cd\u3002<\/p>\n<h3>\u6297\u6c27\u5316\u5242\u662f\u4ec0\u4e48\uff1f<\/h3>\n<p>\u6297\u6c27\u5316\u5242\u662f\u4e00\u7c7b\u4fdd\u62a4\u8eab\u4f53\u514d\u53d7\u635f\u4f24\u7684\u7269\u8d28\u3002\u5b83\u4eec\u80fd\u591f\u4e2d\u548c\u4f53\u5185\u7684\u81ea\u7531\u57fa\uff0c\u9632\u6b62\u8fd9\u4e9b\u81ea\u7531\u57fa\u5bf9\u7ec6\u80de\u9020\u6210\u4f24\u5bb3\u3002\u81ea\u7531\u57fa\u662f\u4e00\u79cd\u5728\u6b63\u5e38\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u4e0d\u7a33\u5b9a\u5206\u5b50\uff0c\u5b83\u4eec\u4f1a\u5077\u53d6\u5176\u4ed6\u5206\u5b50\u7684\u7535\u5b50\uff0c\u5bfc\u81f4\u7ec6\u80de\u635f\u4f24\u3002<\/p>\n<h3>\u81ea\u7531\u57fa\u548c\u6c27\u5316\u5e94\u6fc0<\/h3>\n<p>\u81ea\u7531\u57fa\u662f\u4f53\u5185\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u526f\u4ea7\u54c1\uff0c\u6bd4\u5982\u5728\u6d88\u5316\u98df\u7269\u6216\u66b4\u9732\u4e8e\u9633\u5149\u3001\u70df\u96fe\u548c\u6c61\u67d3\u7269\u65f6\u90fd\u4f1a\u4ea7\u751f\u3002\u867d\u7136\u5c11\u91cf\u7684\u81ea\u7531\u57fa\u662f\u6b63\u5e38\u7684\uff0c\u4f46\u8fc7\u591a\u7684\u81ea\u7531\u57fa\u4f1a\u5f15\u8d77\u6c27\u5316\u5e94\u6fc0\u3002\u8fd9\u79cd\u5e94\u6fc0\u4f1a\u7834\u574f\u7ec6\u80de\u819c\u3001\u86cb\u767d\u8d28\u548cDNA\uff0c\u5bfc\u81f4\u8870\u8001\u548c\u5404\u79cd\u75be\u75c5\uff0c\u5982\u764c\u75c7\u3001\u5fc3\u810f\u75c5\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002<\/p>\n<h3>\u6297\u6c27\u5316\u5242\u7684\u4f5c\u7528<\/h3>\n<p>\u6297\u6c27\u5316\u5242\u901a\u8fc7\u4e2d\u548c\u81ea\u7531\u57fa\u6765\u4fdd\u62a4\u8eab\u4f53\uff0c\u9632\u6b62\u5b83\u4eec\u5f15\u53d1\u6c27\u5316\u5e94\u6fc0\u3002\u5b83\u4eec\u901a\u8fc7\u63d0\u4f9b\u7535\u5b50\u6765\u7a33\u5b9a\u81ea\u7531\u57fa\uff0c\u4ece\u800c\u9632\u6b62\u81ea\u7531\u57fa\u5bf9\u7ec6\u80de\u7684\u8fdb\u4e00\u6b65\u635f\u5bb3\u3002<\/p>\n<h3>\u5e38\u89c1\u7684\u6297\u6c27\u5316\u5242<\/h3>\n<ul>\n<li>\n<p>\u7ef4\u751f\u7d20C\uff1a\u5b58\u5728\u4e8e\u67d1\u6a58\u7c7b\u6c34\u679c\uff08\u5982\u6a59\u5b50\u3001\u67e0\u6aac\uff09\u3001\u8349\u8393\u548c\u83e0\u83dc\u4e2d\uff0c\u6709\u52a9\u4e8e\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\u3002<\/p>\n<\/li>\n<li>\n<p>\u7ef4\u751f\u7d20E\uff1a\u5b58\u5728\u4e8e\u575a\u679c\u3001\u79cd\u5b50\u548c\u7eff\u53f6\u852c\u83dc\u4e2d\uff0c\u6709\u52a9\u4e8e\u4fdd\u62a4\u7ec6\u80de\u819c\u3002<\/p>\n<\/li>\n<li>\n<p>\u80e1\u841d\u535c\u7d20\uff1a\u5982\u03b2-\u80e1\u841d\u535c\u7d20\uff0c\u5b58\u5728\u4e8e\u80e1\u841d\u535c\u3001\u5357\u74dc\u548c\u7518\u85af\u4e2d\uff0c\u6709\u52a9\u4e8e\u7ef4\u6301\u89c6\u529b\u548c\u76ae\u80a4\u5065\u5eb7\u3002<\/p>\n<\/li>\n<li>\n<p>\u591a\u915a\u7c7b\uff1a\u5b58\u5728\u4e8e\u7eff\u8336\u3001\u7ea2\u9152\u3001\u5de7\u514b\u529b\u548c\u84dd\u8393\u4e2d\uff0c\u6709\u52a9\u4e8e\u964d\u4f4e\u708e\u75c7\u548c\u6539\u5584\u5fc3\u810f\u5065\u5eb7\u3002<\/p>\n<\/li>\n<\/ul>\n<h3>\u996e\u98df\u4e2d\u7684\u6297\u6c27\u5316\u5242<\/h3>\n<p>\u8981\u83b7\u5f97\u8db3\u591f\u7684\u6297\u6c27\u5316\u5242\uff0c\u6700\u597d\u7684\u65b9\u6cd5\u662f\u901a\u8fc7\u5747\u8861\u996e\u98df\uff0c\u5305\u62ec\u5404\u79cd\u6c34\u679c\u548c\u852c\u83dc\u3002\u4ee5\u4e0b\u662f\u4e00\u4e9b\u5bcc\u542b\u6297\u6c27\u5316\u5242\u7684\u98df\u7269\uff1a<\/p>\n<ul>\n<li>\n<p>\u6c34\u679c\uff1a\u5982\u84dd\u8393\u3001\u8349\u8393\u3001\u6a59\u5b50\u3001\u82f9\u679c\u548c\u8461\u8404\u3002<\/p>\n<\/li>\n<li>\n<p>\u852c\u83dc\uff1a\u5982\u83e0\u83dc\u3001\u80e1\u841d\u535c\u3001\u897f\u7ea2\u67ff\u548c\u897f\u5170\u82b1\u3002<\/p>\n<\/li>\n<li>\n<p>\u575a\u679c\u548c\u79cd\u5b50\uff1a\u5982\u674f\u4ec1\u3001\u8475\u82b1\u7c7d\u548c\u4e9a\u9ebb\u7c7d\u3002<\/p>\n<\/li>\n<li>\n<p>\u996e\u54c1\uff1a\u5982\u7eff\u8336\u548c\u7ea2\u9152\uff08\u9002\u91cf\u996e\u7528\uff09\u3002<\/p>\n<\/li>\n<\/ul>\n<p>\u591a\u915a\u4e0e\u9ec4\u916e<\/p>\n<p>\u591a\u915a\u662f\u4e00\u7c7b\u5316\u5408\u7269\uff0c\u4e3b\u8981\u5b58\u5728\u4e8e\u690d\u7269\u4e2d\uff0c\u56e0\u5176\u4e30\u5bcc\u7684\u5065\u5eb7\u76ca\u5904\u800c\u53d7\u5230\u5e7f\u6cdb\u5173\u6ce8\u3002\u8fd9\u4e9b\u5316\u5408\u7269\u5728\u690d\u7269\u4e2d\u7684\u4f5c\u7528\u5305\u62ec\u9632\u5fa1\u7d2b\u5916\u7ebf\u6216\u75c5\u539f\u4f53\u4fb5\u5bb3\u7b49\u3002\u5bf9\u4eba\u7c7b\u800c\u8a00\uff0c\u591a\u915a\u56e0\u5176\u6297\u6c27\u5316\u548c\u6297\u708e\u4f5c\u7528\u800c\u88ab\u7814\u7a76\uff0c\u8fd9\u4e9b\u7279\u6027\u6709\u52a9\u4e8e\u9632\u6cbb\u591a\u79cd\u75be\u75c5\uff0c\u5982\u5fc3\u8840\u7ba1\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u751a\u81f3\u67d0\u4e9b\u7c7b\u578b\u7684\u764c\u75c7\u3002<\/p>\n<p>\u9ec4\u916e\u662f\u591a\u915a\u7684\u4e00\u79cd\uff0c\u662f\u4e00\u5927\u7c7b\u5b58\u5728\u4e8e\u690d\u7269\u4e2d\u7684\u6709\u8272\u5316\u5408\u7269\uff0c\u4e5f\u5177\u6709\u6297\u6c27\u5316\u548c\u6297\u708e\u7279\u6027\u3002\u9ec4\u916e\u5728\u591a\u915a\u5bb6\u65cf\u4e2d\u5982\u540c\u6210\u5458\u4e4b\u4e00\uff0c\u5177\u4f53\u5305\u62ec\u9ec4\u916e\u9187\u3001\u9ec4\u70f7\u916e\u7b49\u51e0\u79cd\u7c7b\u578b\u3002\u9ec4\u916e\u4e0d\u4ec5\u8d1f\u8d23\u690d\u7269\u7684\u989c\u8272\uff0c\u8fd8\u6709\u52a9\u4e8e\u4fdd\u62a4\u690d\u7269\u514d\u53d7\u5916\u90e8\u4f24\u5bb3\uff0c\u4f8b\u5982\u7d2b\u5916\u7ebf\u6216\u6606\u866b\u653b\u51fb\u3002<\/p>\n<p>\u7b80\u800c\u8a00\u4e4b\uff0c\u591a\u915a\u662f\u4e00\u5927\u7c7b\u5316\u5408\u7269\uff0c\u9ec4\u916e\u662f\u5176\u4e0b\u7684\u4e00\u4e2a\u5b50\u7c7b\u3002\u5b83\u4eec\u90fd\u5b58\u5728\u4e8e\u690d\u7269\u4e2d\uff0c\u5bf9\u4eba\u4f53\u5065\u5eb7\u975e\u5e38\u6709\u76ca\uff0c\u5c24\u5176\u662f\u5728\u6297\u6c27\u5316\u548c\u6297\u708e\u65b9\u9762\u3002\u901a\u8fc7\u98df\u7528\u5bcc\u542b\u8fd9\u4e9b\u5316\u5408\u7269\u7684\u98df\u7269\uff0c\u5982\u852c\u83dc\u3001\u6c34\u679c\u3001\u8336\u3001\u7ea2\u9152\u7b49\uff0c\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u62b5\u5fa1\u8bb8\u591a\u6162\u6027\u75be\u75c5\u3002<\/p>\n<p>D\u9ec4\u916e\uff08DHM\uff09\u6fc0\u6d3b\u7ebf\u7c92\u4f53<\/p>\n<p>D\u9ec4\u916e\uff08DHM\uff09\u662f\u4e00\u79cd\u4ece\u6768\u6885\u79d1\u3001\u8461\u8404\u79d1\u690d\u7269\u4e2d\u63d0\u53d6\u7684\u5929\u7136\u9ec4\u916e\u7c7b\u5316\u5408\u7269\uff0c\u56e0\u5176\u591a\u79cd\u751f\u7269\u6d3b\u6027\u548c\u836f\u7406\u4f5c\u7528\u800c\u53d7\u5230\u5e7f\u6cdb\u5173\u6ce8\u3002DHM\u5177\u6709\u6297\u6c27\u5316\u3001\u6297\u708e\u3001\u4fdd\u809d\u7b49\u591a\u79cd\u5065\u5eb7\u76ca\u5904\u3002<\/p>\n<p>DHM\u5bf9\u7ebf\u7c92\u4f53\u7684\u6fc0\u6d3b\u4f5c\u7528<\/p>\n<li>\n<p>\u5728\u809d\u810f\u4e2d\u7684\u4f5c\u7528\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>DHM\u901a\u8fc7\u6539\u5584\u7ebf\u7c92\u4f53\u547c\u5438\u80fd\u529b\u548c\u6c27\u5316\u8fd8\u539f\u7a33\u6001\u6765\u51cf\u8f7b\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\uff08NAFLD\uff09\u3002\u5177\u4f53\u673a\u5236\u5305\u62ec\u901a\u8fc7AMPK-SIRT3\u4fe1\u53f7\u901a\u8def\u589e\u5f3a\u7ebf\u7c92\u4f53\u590d\u5408\u7269\u7684\u8868\u8fbe\u548c\u9176\u6d3b\u6027\uff0c\u4ee5\u53ca\u6062\u590d\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\uff08SOD2\uff09\u6d3b\u6027\uff0c\u51cf\u5c11\u6c27\u5316\u5e94\u6fc0(Zeng et al., 2019)\u3002<\/p>\n<\/li>\n<li>\n<p>\u5728\u9152\u7cbe\u8bf1\u5bfc\u7684\u809d\u635f\u4f24\u6a21\u578b\u4e2d\uff0cDHM\u901a\u8fc7\u6fc0\u6d3bAMPK\/SIRT-1\/PGC-1\u03b1\u4fe1\u53f7\u901a\u8def\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u751f\u7269\u53d1\u751f\uff0c\u589e\u5f3a\u809d\u7ec6\u80de\u7684\u80fd\u91cf\u4ee3\u8c22(Silva et al., 2020)\u3002<\/p>\n<\/li>\n<\/ul>\n<li>\n<p>\u5728\u9aa8\u9abc\u808c\u4e2d\u7684\u4f5c\u7528\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>DHM\u901a\u8fc7\u8c03\u8282AMPK\u4fe1\u53f7\u901a\u8def\u4fdd\u62a4\u7ebf\u7c92\u4f53\u751f\u7269\u53d1\u751f\uff0c\u5e76\u8c03\u8282\u7ebf\u7c92\u4f53\u52a8\u529b\u5b66\uff08\u5982\u878d\u5408\u548c\u5206\u88c2\uff09\uff0c\u4ece\u800c\u6539\u5584\u9ad8\u539f\u73af\u5883\u4e0b\u7684\u4f53\u80fd\u8868\u73b0(Zou et al., 2014)\u3002<\/p>\n<\/li>\n<li>\n<p>DHM\u4fc3\u8fdb\u6162\u808c\u7ea4\u7ef4\u7684\u8868\u8fbe\u5e76\u6539\u5584\u808c\u8089\u80f0\u5c9b\u7d20\u654f\u611f\u6027\uff0c\u8fd9\u4e5f\u662f\u901a\u8fc7\u6fc0\u6d3bAMPK-PGC-1\u03b1-Sirt3\u4fe1\u53f7\u901a\u8def\u5b9e\u73b0\u7684(Shi et al., 2015)\u3002<\/p>\n<\/li>\n<li>\n<p>\u7b2c\u4e09\u519b\u533b\u5927\u5b66\u5b9e\u9a8c\u53d1\u73b0\uff0c\u5728\u9ad8\u6d77\u62d4\u73af\u5883\u4e2d\uff0c1\uff09DHM\u53ef\u4ee5\u51cf\u5c11\u7ebf\u7c92\u4f53\u7684\u635f\u4f24\uff0c\u53ef\u4ee5\u62b5\u6297\u9ad8\u6d77\u62d4\u5f15\u8d77\u7684\u6c27\u5316\u5e94\u6fc0\u548c\u708e\u75c7\uff0c\u4fdd\u6301\u7ebf\u7c92\u4f53\u7684\u5f62\u6001\u548c\u7ed3\u6784\u7684\u5b8c\u6574\uff0c\u9632\u6b62\u7ebf\u7c92\u4f53\u7684\u80bf\u80c0\u548c\u5d29\u6e83\u30022\uff09DHM\u53ef\u4ee5\u589e\u52a0\u7ebf\u7c92\u4f53\u7684\u6570\u91cf\uff0c\u5b83\u53ef\u4ee5\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u7684\u751f\u957f\u548c\u5206\u88c2\uff0c\u589e\u52a0\u7ebf\u7c92\u4f53\u7684\u5bc6\u5ea6\u30023\uff09DHM\u53ef\u4ee5\u63d0\u9ad8\u7ebf\u7c92\u4f53\u7684\u529f\u80fd\uff0c\u5b83\u53ef\u4ee5\u6fc0\u6d3b\u7ebf\u7c92\u4f53\u7684\u547c\u5438\u94fe\uff0c\u589e\u52a0\u7ebf\u7c92\u4f53\u7684\u80fd\u91cf\u4ea7\u51fa\uff0c\u8ba9\u9aa8\u9abc\u808c\u6709\u66f4\u591a\u7684\u80fd\u91cf\u4f9b\u5e94\u3002\u7814\u7a76\u8ba4\u4e3a\uff0cDHM\u5728\u9ad8\u6d77\u62d4\u73af\u5883\u4e0b\uff0c\u63d0\u5347\u8fd0\u52a8\u80fd\u529b\u7684\u6548\u679c\u8fd8\u6bd4\u7ea2\u666f\u5929\u66f4\u6709\u6548\uff0c\u4e14D\u9ec4\u916e\u7528\u91cf\u4ec5\u4e3a\u7ea2\u666f\u5929\u768415%\u3002\uff08\u53c2\u89c1\uff1a\u300a\u7b2c\u4e09\u519b\u533b\u5927:D\u9ec4\u916e\u63d0\u5347\u9ad8\u6d77\u62d4\u4e0b\u7684\u8fd0\u52a8\u8868\u73b0\u300b\uff09<\/p>\n<\/p>\n<\/li>\n<\/ul>\n<li>\n<p>\u5728\u5927\u8111\u4e2d\u7684\u4f5c\u7528\uff1a<\/p>\n<\/li>\n<ul>\n<li>\n<p>\u5728\u5e15\u91d1\u68ee\u75c5\u4e2d\uff0cDHM\u901a\u8fc7\u6291\u5236\u7cd6\u539f\u5408\u6210\u9176\u6fc0\u9176-3\u03b2\uff08GSK-3\u03b2\uff09\u7684\u6d3b\u6027\uff0c\u51cf\u8f7b\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u548c\u6c27\u5316\u5e94\u6fc0\uff0c\u4ece\u800c\u4fdd\u62a4\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143(Ren et al., 2016)\u3002<\/p>\n<\/li>\n<li>\n<p>DHM&nbsp;\u53ef\u4ee5\u901a\u8fc7\u589e\u52a0\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\u3001\u589e\u5f3a\u7ebf\u7c92\u4f53\u751f\u7269\u53d1\u751f\u548c\u57fa\u56e0\u7ec4\u5b8c\u6574\u6027\u6765\u6062\u590d\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u4ece\u800c\u63d0\u9ad8\u7ebf\u7c92\u4f53\u547c\u5438\u80fd\u529b\u548cATP\u542b\u91cf\uff0c\u51cf\u5c11\u6c27\u5316\u5e94\u6fc0\u3010(Yao et al., 2022)]<\/p>\n<\/li>\n<li>\n<p>DHM\u901a\u8fc7\u63d0\u9ad8\u6297\u6c27\u5316\u9176\uff08\u5982SOD\u3001CAT\u3001GSH-Px\uff09\u7684\u6d3b\u6027\uff0c\u51cf\u5c11\u8102\u8d28\u8fc7\u6c27\u5316\u4ea7\u7269\uff08\u5982MDA\uff09\u7684\u6c34\u5e73\uff0c\u4ece\u800c\u51cf\u8f7b\u6c27\u5316\u5e94\u6fc0\u5bf9\u8111\u7ec6\u80de\u7684\u635f\u5bb3\u3002<\/p>\n<\/li>\n<li>\n<p>DHM\u901a\u8fc7\u6291\u5236NLRP3\u708e\u6027\u5c0f\u4f53\u7684\u6fc0\u6d3b\uff0c\u51cf\u5c11\u795e\u7ecf\u708e\u75c7\u53cd\u5e94\uff0c\u4ece\u800c\u4fdd\u62a4\u795e\u7ecf\u7ec6\u80de\u3010(Feng et al., 2018)]<\/p>\n<\/li>\n<li>\n<p>DHM\u901a\u8fc7\u6291\u5236A\u03b240\u805a\u96c6\u3001\u963b\u6b62\u539f\u7ea4\u7ef4\u5f62\u6210\u3001\u89e3\u805a\u5df2\u7ecf\u5f62\u6210\u7684A\u03b240\u7ea4\u7ef4\u4ee5\u53ca\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7A\u03b240\u8bf1\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\uff0c\u5c55\u793a\u4e86\u5176\u4f5c\u4e3a\u65b0\u578bA\u03b240\u6291\u5236\u5242\u7684\u6f5c\u529b\u3010(Jia et al., 2019)]<\/p>\n<\/li>\n<li>\n<p>DHM\u901a\u8fc7\u6fc0\u6d3bAMPK\/SIRT1\u4fe1\u53f7\u901a\u8def\uff0c\u6291\u5236\u708e\u75c7\u53cd\u5e94\u548c\u6d77\u9a6c\u7ec6\u80de\u51cb\u4ea1\uff0c\u6539\u5584\u8ba4\u77e5\u529f\u80fd\u3010(Sun et al., 2018)]<\/p>\n<\/li>\n<\/ul>\n<p>DHM\u901a\u8fc7\u591a\u79cd\u673a\u5236\u5728\u4e0d\u540c\u7684\u7ec4\u7ec7\u4e2d\u6fc0\u6d3b\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u5305\u62ec\u6539\u5584\u7ebf\u7c92\u4f53\u547c\u5438\u80fd\u529b\u3001\u589e\u5f3a\u6297\u6c27\u5316\u80fd\u529b\u548c\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u751f\u7269\u53d1\u751f\u3002\u5176\u5e7f\u6cdb\u7684\u751f\u7269\u6d3b\u6027\u4f7f\u5176\u5728\u5065\u5eb7\u4fc3\u8fdb\u548c\u75be\u75c5\u9884\u9632\u65b9\u9762\u5177\u6709\u6f5c\u529b\u3002<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9648\u4fca\u65ed\u533b\u5e08\uff0c\u6bd5\u4e1a\u4e8e\u53f0\u6e7e\u5927\u5b66\u590d\u5065\u533b\u5b66\u7cfb\uff0c\u662f\u7f8e\u56fd\u5df4\u65af\u5e1d\u5c14\u5927\u5b66\u81ea\u7136\u533b\u5b66\u535a\u58eb\uff0c\u4e8e\u7f8e\u56fd\u52a0\u5dde &hellip; <a href=\"http:\/\/zydq.1006ss.com\/?p=41340\">\u7ee7\u7eed\u9605\u8bfb <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-41340","post","type-post","status-publish","format-standard","hentry","category-70"],"_links":{"self":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/41340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41340"}],"version-history":[{"count":0,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=\/wp\/v2\/posts\/41340\/revisions"}],"wp:attachment":[{"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41340"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=41340"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zydq.1006ss.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=41340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}