\u6458\u2004\u8981\uff1a\u63a2\u8ba8\u5375\u5de2\u65e9\u8870\uff08POF\uff09\u53ca\u7edd\u7ecf\u7efc\u5408\u5f81\u7684\u4e34\u5e8a\u8bca\u65ad\u4e0e\u6cbb\u7597\u65b9\u6cd5\u3002\u56de\u987e\u5206\u6790\u81ea 2019 \u5e748\u6708\u81f3 2020 \u5e745\u6708\u95f4\u7ecf\u5e72\u7ec6\u80de\u6297\u8870\u8001\u533b\u9662\u6cbb\u7597\u76845\u4f8bPOF\uff0c7\u4f8b\u65e9\u53d1\u6027\u5375\u5de2\u529f\u80fd\u4e0d\u5168\uff08POI\uff09\u4ee5\u53ca\u7edd\u7ecf\u7efc\u5408\u5f81\u60a3\u8005 18 \u4f8b\u7684\u4e34\u5e8a\u8d44\u6599\uff0c\u7ecf\u8fc7\u4e34\u5e8a\u8bca\u65ad\u548c\u6cbb\u7597\uff0c\u7ed3\u679c30\u4f8b\u60a3\u8005\u4e2d\u6cbb\u610811\u4f8b\uff0c\u6709\u654817\u4f8b\uff0c\u65e0\u65482 \u4f8b\uff0c\u5176\u603b\u6709\u6548\u7387 93 %\u3002\u7ecf\u4f7f\u7528\u4f4e\u6c27\u73af\u5883\u57f9\u517b\u7684\u80ce\u76d8\u5e95\u8715\u819c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u540e\uff0c\u5728 28 \u4f8b\u6cbb\u6108\u53ca\u6709\u6548\u60a3\u8005\u4e2d\uff0c\u60a3\u8005\u7684\u4fc3\u5375\u6ce1\u7d20\uff08FSH\uff09\u3001\u9ec4\u4f53\u751f\u6210\u7d20\uff08LH\uff09\u503c\u5177\u6709\u4e0d\u540c\u7a0b\u5ea6\u4e0b\u964d\uff0c\u96cc\u4e8c\u9187\uff08E2\uff09\u503c\u6709\u660e\u663e\u5347\u9ad8\uff0c\u4e0e\u6cbb\u7597\u524d\u76f8\u6bd4\u5dee\u5f02\u663e\u8457\uff08P \uff1c 0.05)\uff0c\u4e14\u672a\u51fa\u73b0\u660e\u663e\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u7ed3\u8bba\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u6297\u5375\u5de2\u65e9\u8870\u6cbb\u7597\u4e2d\u83b7\u5f97\u4e86\u521d\u6b65\u7597\u6548\u3002<\/p>\n<\/p>\n
\u5973\u6027\u5375\u5de2\u529f\u80fd\u51cf\u9000\u662f\u4e00\u4e2a\u9010\u6e10\u8fdb\u5c55\u7684\u8fc7\u7a0b\uff0c\u5728\u4e34\u5e8a\u4e0a\u5375\u5de2\u8870\u9000\u8fc7\u7a0b\uff0c\u4ece\u5e74\u9f84\u4e0a\u5206\u4e3a\u65e9\u53d1\u6027\u5375\u5de2\u529f\u80fd\u4e0d\u5168\uff08premature ovarian insufficiency\uff0cPOI\uff09\u3001\u5375\u5de2\u65e9\u8870\uff08premature ovarian failure\uff0cPOF\uff09\u548c\u66f4\u5e74\u671f\uff0cPOI \u6216 POF \u662f\u4e00\u4e2a\u975e\u5e38\u590d\u6742\u7684\u75be\u75c5\uff0c\u533b\u5b66\u754c\u81f3\u4eca\u4ecd\u5728\u6301\u7eed\u63a2\u7d22\u3002\u7531\u4e8e\u5e74\u9f84\u3001\u9057\u4f20\u4ee5\u53ca\u836f\u7269\u7b49\u539f\u56e0\u5bfc\u81f4\u5375\u5de2\u529f\u80fd\u8870\u9000\uff0c\u4ea7\u751f\u5375\u5b50\u8d28\u91cf\u964d\u4f4e\u3001\u96cc\u6fc0\u7d20\u6c34\u5e73\u5f02\u5e38\u7b49\u4e34\u5e8a\u8868\u73b0\u3002<\/p>\n
POI \u53c8\u79f0\u539f\u53d1\u6027\u5375\u5de2\u529f\u80fd\u4e0d\u5168\uff0c\u662f\u7531\u9057\u4f20\u6027\u67d3\u8272\u4f53\u5f02\u5e38\u5bfc\u81f4\u7684\u5375\u5de2\u529f\u80fd\u51cf\u9000\u6027\u75be\u75c5\uff0c \u6307\u5973\u6027 40 \u5c81\u4ee5\u524d\u51fa\u73b0\u7684\u5375\u5de2\u529f\u80fd\u51cf\u9000\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u6708\u7ecf\u5f02\u5e38\u3001\u4e0d\u5b55\u4e0d\u80b2\uff0c\u4fc3\u5375\u6ce1\u7d20\uff08FSH\uff09\u6c34\u5e73\u5347\u9ad8\uff08FSH \uff1e 25 IU\/L\uff09\u3001\u96cc\u6fc0\u7d20\u6ce2\u52a8\u6027\u4e0b\u964d\u3002\u53d1\u75c5\u7387\u4e3a 1 %\u223c5 %\uff0c\u5e76\u6709\u589e\u52a0\u8d8b\u52bf\uff0c\u8be5\u75be\u75c5\u5f02\u8d28\u6027\u5f3a\u3001\u53d1\u5c55\u8fc5\u901f\uff0c\u80fd\u591f\u9020\u6210\u5973\u6027\u6392\u5375\u969c\u788d\uff0c\u4e25\u91cd\u5f71\u54cd\u751f\u80b2\u529b\u548c\u8eab\u4f53\u5065\u5eb7\u3002POF \u4e3a\u5375\u5de2\u529f\u80fd\u8870\u7aed\u6240\u5bfc\u81f4\u7684 40 \u5c81\u4e4b\u524d\u5373\u95ed\u7ecf\u7684\u73b0\u8c61\u3002<\/p>\n<\/p>\n
\u5375\u5de2\u65e9\u8870\u7684\u5e38\u89c1\u4e34\u5e8a\u7279\u70b9\u4e3b\u8981\u6709\u4e0d\u5b55\u3001\u6708\u7ecf\u5931\u8c03\u3001\u95ed\u7ecf\uff0c\u5375\u5de2\u65e9\u8870\u60a3\u800510 %~20 %\u4f1a\u51fa\u73b0\u7a81\u7136\u95ed\u7ecf\uff0c\u5927\u591a\u6570\u60a3\u8005\u8868\u73b0\u4e3a\u6708\u7ecf\u7a00\u53d1\u3001\u7ecf\u91cf\u51cf\u5c11\u3001\u7ecf\u671f\u7f29\u77ed\u800c\u9010\u6e10\u95ed\u7ecf\uff1b\u4f4e\u96cc\u6fc0\u7d20\u75c7\u72b6\u4e3b\u8981\u8868\u73b0\u5728\u4e3a\u8840\u7ba1\u8212\u7f29\u75c7\u72b6\u3001\u6ccc\u5c3f\u751f\u6b96\u9053\u75c7\u72b6\u3001\u8fdc\u671f\u8fd8\u4f1a\u9020\u6210\u9aa8\u8d28\u758f\u677e\u548c\u9aa8\u6298\u3001\u8840\u8102\u5347\u9ad8\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u3002<\/p>\n
\u5176\u75c5\u56e0\u6d89\u53ca\u5fc3\u7406\u3001\u9057\u4f20\u3001\u514d\u75ab\u3001\u9176\u4ee3\u8c22\u3001\u611f\u67d3\u3001\u73af\u5883\u53ca\u533b\u6e90\u6027\u56e0\u7d20\u7b49\u591a\u4e2a\u65b9\u9762\uff0c\u591a\u6570\u4e3a\u7279\u53d1\u6027\uff0c\u53d1\u75c5\u673a\u5236\u5c1a\u4e0d\u660e\u786e\uff0c\u4ecd\u65e0\u6839\u672c\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u5e72\u7ec6\u80de\u79fb\u690d\u662f\u76ee\u524d\u56fd\u5185\u5916\u5b66\u8005\u7814\u7a76\u8f83\u591a\u7684\u4e00\u79cd\u65b0\u7684\u7ec6\u80de\u7597\u6cd5\uff0c\u672c\u7814\u7a76\u91c7\u7528\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7528\u4e8e POF \u6cbb\u7597\uff0c\u4ee5\u671f\u83b7\u5f97\u8f83\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n
1\u3001\u8d44\u6599\u4e0e\u65b9\u6cd5<\/p>\n
1.1 \u4e34\u5e8a\u8d44\u6599<\/p>\n
\u5375\u5de2\u65e9\u8870\u60a3\u8005 5 \u4f8b\uff0c\u5e74\u9f84 29~40 \u5c81\uff0cPOI 7\u4f8b\uff0c\u5e74\u9f84 29\u223c40 \u5c81\uff1b\u56f4\u7edd\u7ecf\u53ca\u7edd\u7ecf\u540e\u60a3\u800518 \u4f8b\uff0c\u5176\u4e2d 40~50 \u5c81 11 \u4f8b\uff0c51\u223c59 \u5c81 7 \u4f8b . \u60a3\u8005\u5e73\u5747\u521d\u6f6e\u5e74\u9f84 12~17 \u5c81\uff0c\u95ed\u7ecf 4 \u4e2a\u6708\u81f3 9 \u5e74\uff0c\u6708\u7ecf\u7a00\u53d1\uff0c\u6e10\u81f3\u95ed\u7ecf 23 \u4f8b\uff0c\u7a81\u7136\u95ed\u7ecf 7 \u4f8b\u3002\u672a\u5a5a 3 \u4f8b\uff0c\u5df2\u5a5a 29 \u4f8b\uff0c\u5176\u4e2d 22 \u4f8b\u6709\u4e0d\u540c\u7a0b\u5ea6\u4f4e\u96cc\u6fc0\u7d20\u8840\u75c7\u8868\u73b0\uff0c\u539f\u53d1\u4e0d\u5b55 6 \u4f8b\uff0c\u7ee7\u53d1\u4e0d\u5b55 9 \u4f8b\uff1b12 \u4f8b\u6709\u4e0d\u540c\u7a0b\u5ea6\u751f\u6b96\u5668\u548c\u4e73\u623f\u840e\u7f29\uff0c\u840e\u7f29\u7a0b\u5ea6\u4e0e\u95ed\u7ecf\u5e74\u9650\u6709\u5173\uff1b\u95ed\u7ecf\u65f6\u95f4\u8d8a\u957f\uff0c\u751f\u6b96\u5668\u840e\u7f29\u8d8a\u4e25\u91cd\u300230 \u4f8b\u5747\u68c0\u6d4b\u8840\u6e05\u4fc3\u5375\u6ce1\u7d20\uff08FSH\uff09\u3001\u9ec4\u4f53\u751f\u6210\u7d20\uff08LH\uff09\u3001\u50ac\u4e73\u7d20\uff08PRL\uff09 \u548c\u96cc\u6fc0\u7d201~3\u6b21\u3002\u5987\u79d1\u68c0\u67e5\u5927\u90e8\u5206\u60a3\u8005\u9634\u6bdb\u7a00\u5c11\uff0c\u9634\u9053\u5206\u6ccc\u7269\u5c11\uff0c\u9634\u9053\u58c1\u9ecf\u819c\u8584\uff0c\u90e8\u5206\u60a3\u8005\u540c\u65f6\u5408\u5e76\u9634\u9053\u708e\uff0c\u5b50\u5bab\u840e\u7f29\uff0c\u9634\u9053 B \u8d85\u68c0\u67e5\u663e\u793a\u5b50\u5bab\u5c0f\u4e8e\u6b63\u5e38\u5987\u5973\uff0c\u90e8\u5206\u5375\u5de2\u840e\u7f29\uff0c16 \u4f8b\u65e0\u5375\u6ce1\uff0c8 \u4f8b\u6709\u5375\u6ce1\uff0c\u9634\u9053\u8131\u843d\u7ec6\u80de\u5b66\u63d0\u793a\u96cc\u6fc0\u7d20\u6c34\u5e73\u4f4e\u4e0b\uff0c\u5bab\u9888\u9ecf\u6db2 \u5e73\u5206\u4f4e\u3002<\/p>\n
1.2. \u8bca\u65ad\u6807\u51c6<\/p>\n
\u5375\u5de2\u65e9\u8870\uff08POF\uff09\u8bca\u65ad\u6807\u51c6\uff1a\u60a3\u8005\u5728 40 \u5c81\u4ee5\u524d\u51fa\u73b0\u8d85\u8fc7 4 \u4e2a\u6708\u7684\u95ed\u7ecf\uff0c\u96cc\u4e8c\u9187\uff08E2\uff09\u6c34\u5e73\uff1c 73.2 pmol\/l\uff0c\u540c\u65f6\u6709 2 \u6b21\u4ee5\u4e0a\u8840\u6e05\u4fc3\u5375\u6ce1\u7d20\u8d85\u8fc7 40 U\/L\uff0c2 \u6b21\u68c0\u67e5\u95f4\u9694\u8d85\u8fc7 1 \u4e2a\u6708\u3002<\/p>\n
POI \u8bca\u65ad\u6807\u51c6\uff1aPOI \u662f\u6307\u5973\u6027\u5728 40 \u5c81\u4ee5\u524d\u51fa\u73b0\u5375\u5de2\u529f\u80fd\u51cf\u9000\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u6708\u7ecf\u5f02\u5e38\uff08\u95ed\u7ecf\u3001\u6708\u7ecf\u7a00\u53d1\u6216\u9891\u53d1\uff09\u3001\u4fc3\u6027\u817a\u6fc0\u7d20\u5347\u9ad8\uff08FSH \uff1e 25 IU\/L\uff09\u3001\u96cc\u6fc0\u7d20\u7f3a\u4e4f\u3002<\/p>\n
\u7edd\u7ecf\u7efc\u5408\u5f81\u8bca\u65ad\u6807\u51c6\uff1a\u2460 \u8840\u6e05 FSH \u503c\u53ca E2 \u503c\u6d4b\u5b9a\u7edd\u7ecf\u8fc7\u6e21\u671f\u8840\u6e05 FSH \uff1e 10 U\/L\uff0c\u63d0\u793a\u5375\u5de2\u50a8\u5907\u529f\u80fd\u4e0b\u964d\u3002\u95ed\u7ecf\u3001FSH \uff1e 40U\/L \u4e14 E2 \uff1c 10~20 pg\/mL\uff0c\u63d0\u793a\u5375\u5de2\u529f\u80fd\u8870\u7aed\uff1b\u2461\u6297\u7c73\u52d2\u7ba1\u6fc0\u7d20\uff08AMH\uff09\u6d4b\u5b9a AMH \u4f4e\u4e8e 1.1 ng\/mL \u63d0\u793a\u5375\u5de2\u50a8\u5907\u4e0b\u964d\uff1b\u4f4e\u4e8e 0.2 ng\/mL \u63d0\u793a\u5373\u5c06\u7edd\u7ecf\uff1b\u7edd\u7ecf\u540e\u4e00\u822c\u6d4b\u4e0d\u51fa\u3002<\/p>\n
1.3 \u8bca\u65ad\u65b9\u6cd5<\/p>\n
\u9996\u5148\u8bb0\u5f55\u5375\u5de2\u529f\u80fd\u51cf\u9000\u60a3\u8005\u7684\u5c31\u8bca\u5e74\u9f84\u3001\u521d\u6f6e\u5e74\u9f84\u3001\u65e2\u5f80\u6708\u7ecf\u5468\u671f\u60c5\u51b5\u3001\u624b\u672f\u53f2\u3001\u751f\u80b2\u53f2\u3001\u7edd\u7ecf\u5e74\u9f84\u3001\u7edd\u7ecf\u5e74\u9650\u3001\u6fc0\u7d20\u66ff\u4ee3\u6cbb\u7597\u60c5\u51b5\u3001\u5438\u70df\u60c5\u51b5\u53ca\u73af\u5883\u60c5\u51b5\u3001\u598a\u5a20\u60c5\u51b5\u53ca\u5bb6\u65cf\u53f2\u7b49\u3002\u540c\u65f6\u91c7\u7528\u7a7a\u8179\u62bd\u8840\uff0c\u5e76\u91c7\u7528\u653e\u5c04\u514d\u75ab\u6cd5\u6765\u6d4b\u5b9a\u60a3\u8005\u7684\u6027\u6fc0\u7d20\u516d\u9879\uff0c\u5373 FSH\u3001LH\u3001\u5b55\u6fc0\u7d20\uff08P\uff09\u3001E2\u3001PRL\u3001\u96c4\u6fc0\u7d20\uff08T\uff09\u3002<\/p>\n
\u53e6\u5916\u9700\u8981\u68c0\u67e5\u60a3\u8005\u7684\u809d\u529f\u80fd\u3001\u80be\u529f\u80fd\u3001\u8840\u8102\u3001\u8840\u7cd6\u3001\u80bf\u6807\u7269\uff0c\u4f20\u67d3\u75c5\u68c0\u6d4b\uff0cHPV\u3001TCT\u4e5f\u8981\u5b9a\u671f\u68c0\u6d4b\u3002<\/p>\n
1.4 \u6cbb\u7597\u65b9\u6cd5<\/p>\n
\u6cbb\u7597\u65b9\u6848\u7684\u9009\u62e9\u9700\u6839\u636e\u60a3\u8005\u7684\u5e74\u9f84\u3001\u4f53\u5185\u6fc0\u7d20\u6c34\u5e73\u4ee5\u53ca\u95ed\u7ecf\u60c5\u51b5\u6765\u5236\u8ba2\u5e72\u7ec6\u80de\u79fb\u690d\u7597\u7a0b\u3002\u60a3\u8005\u672f\u524d\u6392\u7a7a\u8180\u80f1\uff0c\u4e0a\u624b\u672f\u53f0\u53d6\u8180\u80f1\u622a\u77f3\u4f4d\uff0c\u5e38\u89c4\u6d88\u6bd2\u5916\u9634\u3001\u9634\u9053\u3001\u94fa\u5dfe\u3002\u53cc\u5408\u8bca\u68c0\u67e5\u4e86\u89e3\u5b50\u5bab\u3001\u9644\u4ef6\u60c5\u51b5\u548c\u9634\u9053\u540e\u7a79\u9686\u662f\u5426\u81a8\u9686\uff0c\u9634\u9053\u7aa5\u5668\u5145\u5206\u66b4\u9732\u5bab\u9888\u53ca\u9634\u9053\u540e\u7a79\u9686\u5e76\u6d88\u6bd2\uff0c\u5bab\u9888\u94b3\u94b3\u5939\u5bab\u9888\u540e\u5507\u5e76\u5411\u524d\u63d0\u62c9\uff0c\u5145\u5206\u66b4\u9732\u9634\u9053\u540e\u7a79\u9686\uff0c\u518d\u6b21\u6d88\u6bd2\u30026 \u53f7\u9488\u5934\u63a5 2 mL \u6ce8\u5c04\u5668\uff0c\u4e8e\u9634\u9053\u540e\u7a79\u9686\u5de6\u53f3\u4e24\u4fa7\uff0c\u5373\u9634\u9053\u540e\u58c1\u4e0e\u5bab\u9888\u540e\u5507\u4ea4\u754c\u5904\u7a0d\u4e0b\u65b9\u5feb\u901f\u8fdb\u9488\uff0c\u6df1\u7ea6 2 cm\uff0c\u5206\u522b\u6ce8\u5165\u9aa8\u9ad3\u95f4\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\uff0c\u7ec6\u80de\u6570\u91cf\u4e3a10\u00d7107 \uff0c\u6ce8\u5c04\u5b8c\u6bd5\uff0c\u62d4\u51fa\u9488\u5934\u9488\u7ba1\uff0c\u89c1\u6ce8\u5c04\u70b9\u6709\u5c11\u8bb8\u6d3b\u52a8\u6027\u51fa\u8840\uff0c\u5927\u68c9\u7403\u538b\u8feb\u7247\u523b\u8840\u6b62\uff0c\u53d6\u51fa\u9634\u9053\u7aa5\u5668\uff0c\u672f\u6bd5\u3002\u672f\u540e 3 d \u5185\u4e2a\u522b\u60a3\u8005\u53ef\u80fd \u6709\u6781\u5c11\u91cf\u9634\u9053\u51fa\u8840\uff0c\u65e0\u987b\u5904\u7406\uff1b\u672f\u540e 7 d \u5185\u7981\u6b62\u6027\u751f\u6d3b\u3001\u7981\u6b62\u5987\u79d1\u5176\u4ed6\u6cbb\u7597\u5982\u5987\u79d1\u51b2\u6d17\uff1b\u672f\u540e 7 d \u7981\u6b62\u8f9b\u8fa3\u523a\u6fc0\u6027\u98df\u54c1\u53ca\u9152\uff1b\u6ce8\u610f\u4f11\u606f\uff0c\u522b\u52b3\u7d2f\uff1b\u672f\u540e\u534a\u6708\u5185\u52ff\u6851\u62ff\u3001\u6e38\u6cf3\u3002<\/p>\n
1.5 \u7edf\u8ba1\u5b66\u5904\u7406<\/p>\n
\u672c\u6587\u7ed3\u679c\u5747\u4f7f\u7528SPSS13.0ForWindo\u7edf\u8ba1\u8f6f\u4ef6\u5904\u7406\u5b9e\u9a8c\u6570\u636e\uff0c\u4f5c x2 \u68c0\u9a8c\u3002P \uff1c 0.05 \u8868\u793a\u5dee\u5f02\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002<\/p>\n
2\u3001\u7ed3\u679c<\/p>\n
11 \u4f8b POF \u548c POI \u4ee5\u53ca 17 \u4f8b\u7edd\u7ecf\u7efc\u5408\u5f81\u60a3\u8005\u7ecf\u6cbb\u7597\u540e\u5747\u6709\u6708\u7ecf\u6765\u6f6e\uff0c\u540c\u65f6\u5728\u7528\u836f\u4e00\u4e2a\u7597\u7a0b\u540e\u5176\u96cc\u6fc0\u7d20\u7f3a\u4e4f\u75c7\u72b6\u5982\u5931\u7720\u3001\u6f6e\u70ed\u3001\u76d7\u6c57\u3001\u60c5\u7eea\u6ce2\u52a8\u7b49\u75c7\u72b6\u6709\u660e\u663e\u7f13\u89e3\uff0c\u6027\u6fc0\u7d20\u6c34\u5e73\u4e5f\u6709\u660e \u663e\u6539\u5584\uff0c\u5177\u4f53\u5185\u5bb9\u8be6\u89c1\u8868 1\u3002<\/p>\n<\/p>\n
2 \u4f8b\u60a3\u8005\uff0cPOF \u548c POI \u5404 1 \u4f8b\uff0c\u5e74\u9f84\u5747\u5c0f\u4e8e 40 \u5c81\uff0cFSH \u4e0e E2 \u6c34\u5e73\u4e0e\u5bf9\u7167\u7ec4\u65e0\u663e\u8457\u6027\u5dee\u522b\uff0c\u4f46\u5931\u7720\u3001\u7126\u8651\u7b49\u75c7\u72b6\u660e\u663e\u6539\u5584\u3002<\/p>\n
3\u3001\u8ba8\u8bba<\/p>\n
\u5375\u5de2\u529f\u80fd\u8870\u9000\u4e25\u91cd\u5f71\u54cd\u5973\u6027\u5065\u5eb7\uff0c\u6210\u4e3a\u5973\u6027\u5065\u5eb7\u7684\u76f4\u63a5\u6740\u624b\u3002\u5375\u5de2\u65e9\u8870\uff08POF\uff09\u662f\u5973\u6027 40 \u5c81\u524d\u7531\u4e8e\u5375\u5de2\u5185\u5375\u6ce1\u8017\u7aed\u6216\u56e0\u533b\u6e90\u6027\u635f\u4f24\u800c\u53d1\u751f\u7684\u5375\u5de2\u529f\u80fd\u8870\u7aed\uff0c\u60a3\u8005\u51fa\u73b0\u6301\u7eed\u6027\u95ed\u7ecf\u3001\u6027\u5668\u5b98\u840e\u7f29\uff0c\u4f34\u6709\u4fc3\u6027\u817a\u6fc0\u7d20\u5305\u62ec FSH \u548c LH \u5347\u9ad8\uff0c\u800c\u96cc\u6fc0\u7d20\u964d\u4f4e\u7684\u7efc\u5408\u5f81 [1]\u3002<\/p>\n
POF \u662f\u5987\u79d1\u5185\u5206\u6ccc\u9886\u57df\u7684\u5e38\u89c1\u75c5\uff0c\u5176\u5728\u4e00\u822c\u4eba\u7fa4\u4e2d\u53d1\u75c5\u7387\u4e3a 1 %~3 %\uff0c20 \u5c81\u524d\u5973\u6027\u53d1\u75c5\u7387 0.01 %\uff0c30 \u5c81\u524d\u53d1\u751f\u7387 0.1 %\uff0c40 \u5c81\u524d\u53d1\u751f\u7387\u4e3a 1 %\uff0c\u5728\u7ee7\u53d1\u6027\u95ed\u7ecf\u5987\u5973\u4e2d\u5360 4 %\u223c8 %[2~3]\u3002\u8fd1\u5e74\u6765\u5375\u5de2\u65e9\u8870\u5728\u80b2\u9f84\u5987\u5973\u4e2d\u7684\u53d1\u751f\u7387\u6709\u9010\u5e74\u5347\u9ad8\u4e14\u5411\u5e74\u8f7b\u5316\u53d1\u5c55\u7684\u8d8b\u52bf\uff0c\u5728\u5973\u6027\u4e0d\u5b55\u60a3\u8005\u4e2d\u6240\u5360\u7684\u6bd4\u4f8b\u9010\u5e74\u4e0a\u5347\u3002<\/p>\n
\u800c\u5176\u673a\u5236\u5c1a\u4e0d\u660e\u786e\uff0c\u4e3b\u8981\u8bf1\u56e0\u5305\u62ec\u9057\u4f20\u3001\u81ea\u8eab\u514d\u75ab\u3001\u533b\u7597\u624b\u672f\u521b\u4f24\u3001\u73af\u5883\u3001\u611f\u67d3\u7b49\u3002\u7814\u7a76\u8868\u660e\uff0c37 % \u7684 POF \u7531\u6297\u80bf\u7624\u6cbb\u7597\u7b49\u533b\u6e90\u6027\u56e0\u7d20\u5f15\u8d77\uff0c\u7279\u53d1\u6027\u5360 25 %\uff0c\u9057\u4f20\u548c\u514d\u75ab\u56e0\u7d20\u5404\u5360 19 % \u5de6\u53f3\uff0c\u4e0d\u826f\u751f\u6d3b\u3001\u5de5\u4f5c\u65b9\u5f0f\u4e5f\u6210\u4e3a\u5176\u8bf1\u56e0 [4]\u3002<\/p>\n
\u5375\u5de2\u529f\u80fd\u8870\u9000\u5bf9\u5973\u6027\u751f\u6b96\u5065\u5eb7\u9020\u6210\u7684\u4e24\u5927\u5a01\u80c1\u4e3b\u8981\u662f\u96cc\u6fc0\u7d20\u6c34\u5e73\u964d\u4f4e\u53ca\u751f\u80b2\u80fd\u529b\u4e27\u5931\uff0c\u96cc\u6fc0\u7d20\u6c34\u5e73\u964d\u4f4e\u589e\u52a0\u4e86\u5987\u5973\u60a3\u9aa8\u8d28\u758f\u677e\u548c\u51a0\u5fc3\u75c5\u7684\u98ce\u9669 [5]\u3002\u800c\u5904\u4e8e\u751f\u80b2\u671f\u7684\u5987\u5973\u63d0\u65e9\u95ed\u7ecf\uff0c\u751f\u80b2\u80fd\u529b\u4e27\u5931\uff0c\u5bfc\u81f4\u4e00\u7cfb\u5217\u5fc3\u7406\u548c\u793e\u4f1a\u95ee\u9898\uff0c\u5982\u6291\u90c1\u3001\u7126\u8651\u3001\u4eba\u9645\u4ea4\u5f80\u56f0\u96be\u3001\u654c\u5bf9\u60c5\u7eea\u3001\u793e\u4ea4\u969c\u788d\u53ca\u5a5a\u59fb\u751f\u6d3b\u8d28\u91cf\u4e0b\u964d [6]\u3002<\/p>\n
\u9488\u5bf9\u5df2\u77e5\u7684\u53d1\u75c5\u539f\u56e0\u548c\u673a\u5236\uff0c\u76ee\u524d\u4e3b\u8981\u7684\u6cbb\u7597\u63aa\u65bd\u5305\u62ec\u6fc0\u7d20\u66ff\u4ee3\u6cbb\u7597\uff08HRT\uff09\u3001\u4fc3\u6027\u817a\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\u53d7\u4f53\u6fc0\u52a8\u5242\u6cbb\u7597\u3001\u51b7\u51bb\u7ec4\u7ec7\uff08\u5375\u6bcd\u7ec6\u80de\u3001\u5375\u5de2\u7ec4\u7ec7\u3001\u80da\u80ce\uff09\u79fb\u690d\u3001\u514d\u75ab\u8c03\u8282\u3001\u57fa\u56e0\u6cbb\u7597\u7b49 [7-8]\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u6cbb\u7597\u7684\u6548\u679c\u4e3b\u8981\u4ee5\u6539\u5584\u4e34\u5e8a\u75c7\u72b6\u4e3a\u4e3b\uff0c\u96be\u4ee5\u5b8c\u5168\u6062\u590d\u5375\u5de2\u6b63\u5e38\u529f\u80fd\uff0c\u8fd8\u5b58\u5728\u660e\u663e\u4e0d\u826f\u53cd\u5e94\uff0c\u5982\u957f\u671f HRT \u6709\u589e\u52a0\u4e73\u817a\u764c\u3001\u5fc3\u810f\u75c5\u548c\u4e2d\u98ce\u98ce\u9669\u7684\u62c5\u5fe7\uff0c\u56e0\u6b64\uff0c\u5bfb\u627e\u4e00\u79cd\u6062\u590d\u5375\u5de2\u529f\u80fd\u6cbb\u7597\u624b\u6bb5\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n<\/p>\n
\u8fd1\u5e74\u6765\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u7597\u6cd5\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u4fee\u590d\u53d7\u635f\u7ec4\u7ec7\u3001\u91cd\u5efa\u6b63\u5e38\u7ec4\u7ec7\u529f\u80fd\u7684\u66ff\u4ee3\u6cbb\u7597\u624b\u6bb5\uff0c\u56e0\u5176\u6cbb\u7597\u8303\u56f4\u5e7f\u6cdb\u548c\u6f5c\u5728\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\uff0c\u9010\u6e10\u6210\u4e3a\u7814\u7a76\u70ed\u70b9\uff0c\u4e5f\u4e3a\u5305\u62ec\u5375\u5de2\u65e9\u8870\u5728\u5185\u7684\u5404\u79cd\u96be\u6cbb\u6027\u75be\u75c5\u5e26\u6765\u4e86\u65b0\u5e0c\u671b\u3002\u5e72\u7ec6\u80de\u80fd\u591f\u5b9a\u5411\u4fee\u590d\u5375\u5de2\u7ec4\u7ec7\u5206\u5316\u51fa\u8db3\u591f\u7684\u5375\u7ec6\u80de\uff0c\u8865\u5145\u5375\u7ec6\u80de\u6570\u91cf\uff0c\u7ef4\u62a4\u5375\u5de2\u6b63\u5e38\u7684\u5f62\u6001\u548c\u529f\u80fd\uff0c\u4f7f\u60a3\u8005\u5fc3\u7406\u5e74\u9f84\u63d0\u9ad8\uff0c\u91cd\u65b0\u7115\u53d1\u9752\u6625\u98ce\u91c7\u3002<\/p>\n
\u672c\u7814\u7a76\u7ed3\u679c\u8868\u660e 30 \u4f8b\u60a3\u8005\u4e2d\uff0c28 \u4f8b MSC \u9776\u5411\u6cbb\u7597\u5747\u83b7\u5f97\u826f\u597d\u7684\u7597\u6548\uff0c\u901a\u8fc7\u6cbb\u7597\u523a\u6fc0\u4f53\u5185\u8377\u5c14\u8499\u5206\u6ccc\u96cc\u6027\u6fc0\u7d20\uff0c\u63d0\u9ad8\u4f53\u5185\u7684\u96cc\u6027\u6fc0\u7d20\u6c34\u5e73\uff0c\u51cf\u8f7b\u4e86\u66f4\u5e74\u671f\u51fa\u73b0\u7684\u5931\u7720\u3001\u591a\u68a6\u3001\u813e\u6c14\u66b4\u8e81\u7b49\u75c7\u72b6\uff0c\u5e76\u63a8\u8fdf\u66f4\u5e74\u671f\u7684\u5230\u6765\uff0c\u4ec5 2 \u4f8b \u60a3\u8005\uff08POF \u548c POI \u5404 1 \u4f8b\uff0c\u5e74\u9f84\u5747\u4e3a 40 \u5c81\u4ee5\u4e0b\uff09FSH \u4e0e E2 \u6c34\u5e73\u4e0e\u5bf9\u7167\u7ec4\u65e0\u663e\u8457\u6027\u5dee\u522b\uff0c\u4f46\u5931\u7720\u3001\u7126\u8651\u7b49\u75c7\u72b6\u5f97\u5230\u6539\u5584\uff0c\u63a8\u6d4b\u53ef\u80fd\u4e0e\u5176\u5e74\u9f84\u548c\u5375\u5de2\u529f\u80fd\u4e25\u91cd\u4f4e\u4e0b\u6709\u5173\uff0c\u672a\u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002\u7531\u4e8ePOF\u4e34\u5e8a\u75c5\u56e0\u8f83\u4e3a\u590d\u6742\uff0c\u4e14\u6cbb\u7597\u96be\u5ea6\u8f83\u5927\uff0c\u60a3\u8005\u65e9\u8bca\u65ad\u65e9\u3001\u6cbb\u7597\uff0c \u8fd9\u6837\u4e0d\u4ec5\u53ef\u4ee5\u7f13\u89e3\u4e34\u5e8a\u75c7\u72b6\u3001\u5ef6\u7f13\u75c5\u60c5\u53d1\u5c55\uff0c\u751a\u81f3\u53ef\u6062\u590d\u5375\u5de2\u529f\u80fd\u3002<\/p>\n
\u53c2\u8003\u6587\u732e\uff1a<\/p>\n
[1] \u5de6\u4fa0, \u9648\u857e.\u5e72\u7ec6\u80de\u6cbb\u7597\u5375\u5de2\u65e9\u8870\u7684\u7814\u7a76\u8fdb\u5c55 [J]. \u56fd\u9645\u5987\u4ea7\u79d1\u5b66\u6742\u5fd7 ,2014, (1):25-28.<\/p>\n
[2]Messiah A,Leif MW.Premature ovarian failure[J].Burr Opin Obstet Gynecol,2006,18\u2236 418-426. <\/p>\n
[3]Goswami D,Conway GS. Premature ovarian failure[J].Horm Res,2007,68 (4):196-202.<\/p>\n
[4]Fenton AJ\uff0ePremature ovarian insufficiency: Pathogenesis and management[J].J Midlife Health,2015,6(4):147-153\uff0e<\/p>\n
[5]Gallagher JC. Effect of early menopause on bone mineral density and fractures[J].Menopause,2007,14(3 pt2):567-571.<\/p>\n
[6]Nippita TA,Baber RJ.Premature ovarian failure:a review[J].Climacteric,2007,10 (1):11-22.<\/p>\n
[7]Torrealday S,Kodaman P,Pal L\uff0ePremature Ovarian Insufficiencyan update on recent advances in understanding and management[J]. F1000Res,2017(6):2069-2083\uff0e<\/p>\n
[8]Kozub MM,Prokopiuk VY,Skibina KP,et al\uff0e Comparison of various tissue and cell therapy approaches when restoring ovarian,hepatic and kidney\u2019s function after chemotherapy-induced ovarian failure[J].Exp Oncol,2017,39(3):181-185\uff0e<\/p>\n
\u58f0\u660e\uff1a\u672c\u6587\u6765\u81ea\u5e72\u7ec6\u80de\u4e4b\u7236\u5e73\u53f0\uff0c\u65e8\u5728\u79d1\u666e\u76f8\u5173\u77e5\u8bc6\uff0c\u4f20\u9012\u884c\u4e1a\u524d\u6cbf\u8fdb\u5c55\uff0c\u4e0d\u4f5c\u4e3a\u533b\u7597\u6307\u5bfc\u5efa\u8bae\u3002\u7cbe\u51c6\u533b\u7597\u5f15\u9886\u5065\u5eb7\u672a\u6765 #artContent h1#artContent p img#artContent table<\/p>\n","protected":false},"excerpt":{"rendered":"
\u6458\u2004\u8981\uff1a\u63a2\u8ba8\u5375\u5de2\u65e9\u8870\uff08POF\uff09\u53ca\u7edd\u7ecf\u7efc\u5408\u5f81\u7684\u4e34\u5e8a\u8bca\u65ad\u4e0e\u6cbb\u7597\u65b9\u6cd5\u3002\u56de\u987e\u5206\u6790\u81ea 20 … \u7ee7\u7eed\u9605\u8bfb