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\u4e00\u3001\u5bab\u9888\u764c\u7b5b\u67e5\u6307\u5357\u3001\u7ec6\u80de\u5b66\u62a5\u544a\u7cfb\u7edf\u548c\u4e34\u5e8a\u7ba1\u7406\u6307\u5357\u7684\u5386\u53f2\u56de\u987e<\/p>\n
\u5bab\u9888\u764c\u66fe\u662f\u5168\u7403\u5987\u5973\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u4e2d\uff0c\u5bab\u9888\u764c\u7684\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u663e\u8457\u4e0b\u964d\uff0c\u4e3b\u8981\u662f\u56e0\u4e3a\uff1a<\/p>\n
\uff081\uff09\u5bab\u9888\u764c\u7b5b\u67e5\u7684\u6210\u529f\u666e\u53ca\u5e94\u7528\uff1b<\/p>\n
\uff082\uff09TBS\u5bab\u9888\/\u9634\u9053\u7ec6\u80de\u5b66\u62a5\u544a\u7cfb\u7edf\u7684\u6807\u51c6\u5316\uff1b<\/p>\n
\uff083\uff09\u5bf9HPV\u5728\u5bab\u9888\u764c\u53d1\u75c5\u673a\u7406\u8ba4\u8bc6\u7684\u63d0\u9ad8\uff1b<\/p>\n
\uff084\uff09\u76f8\u5e94\u7684\u7ba1\u7406\u6307\u5357\u7684\u66f4\u65b0\u3002<\/p>\n
1943\u5e74\uff0cGeorge Papanicolaou\u7f16\u5199\u4e86\u300a\u901a\u8fc7\u9634\u9053\u6d82\u7247\u8bca\u65ad\u5b50\u5bab\u764c\u300b\uff0c\u5c06\u5bab\u9888\u7ec6\u80de\u5b66\u4ecb\u7ecd\u7ed9\u4e86\u5168\u4e16\u754c\u3002Diane Solomon\u7b49\u4eba\u4e8e1988\u5e74\u53d1\u5e03\u4e86\u7b2c\u4e00\u7248TBS\uff0c\u4e3a\u5bab\u9888\u7ec6\u80de\u5b66\u63d0\u4f9b\u4e86\u88ab\u5e7f\u6cdb\u63a5\u53d7\u7684\u89c4\u8303\u62a5\u544a\u7cfb\u7edf\uff0c\u4e5f\u4e3a\u4ee5\u540e\u5bab\u9888\u764c\u7b5b\u67e5\u548c\u7ba1\u7406\u6307\u5357\u5236\u5b9a\u63d0\u4f9b\u4e86\u4f9d\u636e\u3002\u6b64\u5916TBS\u7cfb\u7edf\u9996\u6b21\u5c06\u201c\u6837\u672c\u6ee1\u610f\u5ea6\u201d\u52a0\u5165\u7ec6\u80de\u5b66\u62a5\u544a\u4e2d\uff0c\u5e76\u63a8\u8350\u5bf9\u9cde\u72b6\u4e0a\u76ae\u5185\u75c5\u53d8\u5206\u4e24\u7ea7\u62a5\u544a\uff1a\u4f4e\u7ea7\u522b\u75c5\u53d8\u548c\u9ad8\u7ea7\u522b\u75c5\u53d8\u3002\u8fd9\u4e2a\u521d\u59cb\u7248\u7684\u62a5\u544a\u7cfb\u7edf\u4e4b\u76ee\u7684\u662f\u66f4\u6709\u6548\u76f4\u63a5\u5730\u5411\u4e34\u5e8a\u533b\u751f\u4f20\u8fbe\u5bab\u9888\u7ec6\u80de\u5b66\u7684\u53d1\u73b0\u3002\u4e0d\u4e45\u4e4b\u540e\u57281991\u5e74\uff0c\u7f8e\u56fd\u9634\u9053\u955c\u548c\u5bab\u9888\u75c5\u7406\u5b66\u4f1a\uff08ASCCP\uff09\u4e5f\u76f8\u5e94\u7684\u5236\u5b9a\u4e86\u5173\u4e8e\u5bab\u9888\u7ec6\u80de\u5b66\u5f02\u5e38\u7684\u5987\u5973\u8bca\u6cbb\u7684\u6682\u884c\u5171\u8bc6\u6307\u5357\u3002<\/p>\n
\u968f\u7740\u5bf9\u5bab\u9888\u764c\u53d1\u751f\u673a\u5236\u8ba4\u8bc6\u7684\u4e0d\u65ad\u6df1\u5165\uff0c\u66f4\u65b0\u7684TBS 2001\u7248\u589e\u52a0\u4e86\u5bab\u9888\u817a\u75c5\u53d8\u7684\u672f\u8bed\u548c\u5224\u8bfb\u6807\u51c6\uff0c\u5e76\u7b2c\u4e00\u6b21\u5f15\u5165\u6db2\u57fa\u7ec6\u80de\u5b66\u548cHPV\u68c0\u6d4b\u3002\u81f3\u6b64\u63a5\u4e0b\u6765\u768413\u5e74\u4e2d\uff0c2001\u7248\u7684TBS\u5e74\u6210\u4e3a\u56fd\u9645\u7ec6\u80de\u75c5\u7406\u5b66\u754c\u7684\u57fa\u672c\u5bab\u9888\u7ec6\u80de\u5b66\u62a5\u544a\u7684\u6807\u51c6\u6307\u5357\uff0c\u5bf9\u7ec6\u80de\u75c5\u7406\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u751f\u7684\u6559\u80b2\u548c\u5b9e\u8df5\u4ea7\u751f\u4e86\u6df1\u8fdc\u7684\u5f71\u54cd\u3002\u57282006\u5e74\u548c2012\u5e74\uff0c\u4e3a\u4e86\u4e0e\u65b0\u7248\u7684TBS\u672f\u8bed\u4fdd\u6301\u4e00\u81f4\uff0cASCCP\u66f4\u65b0\u4e86\u4e34\u5e8a\u8bca\u6cbb\u7ba1\u7406\u6307\u5357\u30022001\u5e74\u81f32002\u5e74\uff0c\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\uff08ACS\uff09\u4e5f\u9996\u6b21\u53ec\u96c6\u4e86\u591a\u5b66\u79d1\u4e13\u5bb6\u5c0f\u7ec4\uff0c\u53d1\u5e03\u4e86\u5bab\u9888\u764c\u7b5b\u67e5\u6307\u5357\uff0c\u5efa\u8bae\u7b5b\u67e5\u5e74\u9f84\u4e3a20\u5c81\uff0c\u5bf9ASC-US\u52a0\u5165\u53cd\u9988\u6027HPV\u68c0\u6d4b\u30022012\u5e74\uff0cACS\u3001ASCCP\u548cASCP\uff08\u7f8e\u56fd\u4e34\u5e8a\u75c5\u7406\u5b66\u4f1a\uff09\u53c8\u4e00\u6b21\u66f4\u65b0\u4e86\u5bab\u9888\u764c\u7b5b\u67e5\u6307\u5357\u3002\u65b0\u7684\u7b5b\u67e5\u6307\u5357\u6d89\u53ca\u9002\u9f84\u7b5b\u67e5\u7684\u7b56\u7565\u3001\u89c4\u5b9a\u4e86\u7b5b\u67e5\u5e74\u9f84\u7684\u8d77\u59cb\uff0821\u5c81\u5f00\u59cb\uff0c65\u5c81\u7ed3\u675f\uff09\uff0c\u4ee5\u53ca\u63d0\u51fa\u4e86\u63a5\u79cdHPV16\u548cHPV18\u75ab\u82d7\u5973\u6027\u7684\u9884\u9632\u7b56\u7565\u3002<\/p>\n
TBS\u7684\u6700\u65b0\u4fee\u8ba2\u7248\u4e8e2014\u5e7412\u6708\u53d1\u5e03\u3002\u66f4\u65b0\u540e\u7684TBS\u5728\u672f\u8bed\u4e0a\u7ee7\u7eed\u63a8\u8350\u4f7f\u7528\u7edf\u4e00\u548c\u53ef\u91cd\u590d\u7684\u7ec6\u80de\u5b66\u62a5\u544a\uff0c\u5305\u62ec\u4e94\u4e2a\u7ec4\u6210\u90e8\u5206\uff1a\u6807\u672c\u7c7b\u578b\u3001\u6807\u672c\u6ee1\u610f\u5ea6\u8bc4\u4f30\u3001\u603b\u4f53\u5206\u7c7b\u3001\u5224\u8bfb\u610f\u89c1\/\u7ed3\u679c\u548c\u8f85\u52a9\u6027\u68c0\u6d4b\u3002TBS 2014\u7248\u7684\u4e3b\u8981\u66f4\u65b0\u5305\u62ec\uff1a\u826f\u6027\u8868\u73b0\u7684\u5b50\u5bab\u5185\u819c\u7ec6\u80de\u7684\u62a5\u544a\u5e74\u9f84\u7531\u226540\u5c81\u66f4\u6539\u4e3a\u226545\u5c81\uff1b\u4e0d\u63a8\u8350\u4f7f\u7528\u201c\u4f4e\u7ea7\u522b\u9cde\u72b6\u4e0a\u76ae\u5185\u75c5\u53d8\uff0c\u4e0d\u80fd\u6392\u9664\u9ad8\u7ea7\u522b\u9cde\u72b6\u4e0a\u76ae\u5185\u75c5\u53d8LSIL-ASC-H\u201d\u672f\u8bed\u7b49\u30022018\u5e74\uff0c\u7f8e\u56fd\u9884\u9632\u670d\u52a1\u5de5\u4f5c\u7ec4\u5bf9\u5bab\u9888\u764c\u7b5b\u67e5\u518d\u6b21\u505a\u4e86\u66f4\u65b0\uff0c\u5bf9\u4e8e30~65\u5c81\u7684\u5973\u6027\u589e\u52a0\u4e86\u6bcf5\u5e74\u4e00\u6b21\u7684HPV\u5355\u72ec\u68c0\u6d4b\u4f5c\u4e3a\u66ff\u4ee3\u65b9\u6848\u3002<\/p>\n
2020\u5e74\uff0cACS\u53d1\u5e03\u4e86\u6700\u65b0\u7684\u5bab\u9888\u764c\u7b5b\u67e5\u6307\u5357\u3002\u4e0e2012\u7248\u76f8\u6bd4\uff0c\u65b0\u7684ACS\u6307\u5357\u4e3b\u8981\u6709\u4ee5\u4e0b\u56db\u4e2a\u65b9\u9762\u7684\u91cd\u8981\u66f4\u65b0\uff1a<\/p>\n
\uff081\uff09\u9996\u6b21\u7b5b\u67e5\u7684\u5e74\u9f84\u753121\u5c81\u8c03\u6574\u4e3a25\u5c81\uff1b<\/p>\n
\uff082\uff09HPV\u68c0\u6d4b\u4e3a\u4e3b\u7684\u7b5b\u67e5\u3001HPV\u68c0\u6d4b\u4e0e\u7ec6\u80de\u5b66\u8054\u5408\u7b5b\u67e5\u6216\u7ec6\u80de\u5b66\u4e3a\u4e3b\u7684\u7b5b\u67e5\u4ece25\u5c81\u5f00\u59cb\uff1b<\/p>\n
\uff083\uff09\u9996\u9009\u7684\u7b5b\u67e5\u65b9\u6cd5\u5efa\u8bae\u6bcf5\u5e74\u8fdb\u884c\u4e00\u6b21HPV\u68c0\u6d4b\u3002<\/p>\n
2020ACS\u7b5b\u67e5\u6307\u5357\u7684\u63d0\u51fa\uff0c\u662f\u57fa\u4e8eHPV\u68c0\u6d4b\u7ed3\u679c\uff0cHPV\u68c0\u6d4b\u5355\u72ec\u6216\u4e0e\u7ec6\u80de\u5b66\u68c0\u67e5\u8054\u5408\u4f7f\u7528\u7684\u98ce\u9669\u9608\u503c\uff0c\u53ef\u7528\u4e8e\u6307\u5bfc\u4e34\u5e8a\u5904\u7406\uff08\u8c03\u6574\u7b5b\u67e5\u9891\u7387\u3001\u9634\u9053\u955c\u68c0\u67e5\u3001\u6cbb\u7597\u7b49\uff09\u3002\u5f3a\u8c03\u4e86\u4e34\u5e8a\u5904\u7406\u662f\u57fa\u4e8eCIN3\u7684\u53d1\u75c5\u98ce\u9669\u800c\u975e\u68c0\u6d4b\u7ed3\u679c\u30022019\u5e74ASCCP\u4e34\u5e8a\u7ba1\u7406\u6307\u5357\u5c06\u75c5\u4eba\u7684\u5e74\u9f84\u3001\u751f\u80b2\u53f2\u7b49\u4e5f\u7eb3\u5165\u8003\u8651\u56e0\u7d20\u3002\u98ce\u9669\u503c\u7684\u786e\u5b9a\u57fa\u4e8e\u68c0\u67e5\u7ed3\u679c\u548c\u75c5\u53f2\u7684\u7ed3\u5408\u3002HPV16\u9633\u6027\u4e14\u7ec6\u80de\u5b66HISL\u768425\u5c81\u53ca\u4ee5\u4e0a\u5973\u6027\uff0c\u5176CIN3 \u7684\u5373\u65f6\u98ce\u9669\u226560%\uff0c\u56e0\u800c\u9996\u9009\u7acb\u5373\u6cbb\u7597\u3002\u5bf9\u4e8e\u7ec4\u7ec7\u5b66CIN2\/3\u6216\u5bab\u9888\u817a\u764c\uff0c\u9996\u9009\u5207\u9664\u6027\u6cbb\u7597\uff0c\u5bf9\u4e8eCIN1\uff0c\u5efa\u8bae\u8fdb\u884c\u89c2\u5bdf\u6027\u968f\u8bbf\u3002\u82e5\u521d\u7b5bHPV16\u621618\u9633\u6027\uff0c\u5373\u4fbf\u7ec6\u80de\u5b66\u68c0\u67e5\u9634\u6027\uff0c\u4e5f\u9700\u8fdb\u884c\u9634\u9053\u955c\u68c0\u67e5\u548c\u6d3b\u68c0\u3002\u5bf9\u4e8e\u7ec4\u7ec7\u5b66\u9ad8\u7ea7\u75c5\u53d8\u9996\u6b21\u6cbb\u7597\u540e\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u8fdb\u884c\u6bcf3\u5e74\u4e00\u6b21\u7684\u7ec8\u8eab\u968f\u8bbf\u3002<\/p>\n
\u4e8c\u3001Bethesda\u5bab\u9888\u7ec6\u80de\u5b66\u62a5\u544a\u7cfb\u7edf\u4e09\u9879\u6307\u5bfc\u539f\u5219<\/p>\n
1.\u5bab\u9888\u7ec6\u80de\u5b66\u62a5\u544a\u7684\u5206\u7c7b\u672f\u8bed\u5728\u4e16\u754c\u8303\u56f4\u5185\u7684\u4e0d\u540c\u5b9e\u9a8c\u5ba4\u4e4b\u95f4\u5e94\u5f53\u7edf\u4e00\uff0c\u540c\u65f6\u53ef\u4ee5\u6839\u636e\u672c\u5730\u533a\u7684\u60c5\u51b5\u8fdb\u884c\u8c03\u6574\uff1b2.\u5bab\u9888\u7ec6\u80de\u5b66\u62a5\u544a\u5e94\u5f53\u5411\u4e34\u5e8a\u533b\u751f\u63d0\u4f9b\u76f8\u5173\u548c\u4e34\u5e8a\u9002\u7528\u7684\u4fe1\u606f\uff1b3.\u62a5\u544a\u4e2d\u4f7f\u7528\u7684\u672f\u8bed\u5e94\u5f53\u8fdb\u884c\u5b9a\u671f\u66f4\u65b0\uff0c\u4ee5\u547c\u5e94\u5bf9\u5f53\u524d\u5bf9\u4e8e\u5bab\u9888\u764c\u7b5b\u67e5\u7684\u7406\u89e3\u3002<\/p>\n
\u5236\u7247\u65b9\u6cd5<\/p>\n
\u6db2\u57fa\u5236\u7247\uff1aFDA\u6279\u51c6\u7684\u4e24\u79cd\u6db2\u57fa\u5236\u7247\u65b9\u68481.ThinPrep\u2122\uff08Hologic Inc.\uff09\uff1a\u9700\u8981\u4e00\u53f0\u8bbe\u5907\u548c\u7279\u6b8a\u7684\u805a\u78b3\u9178\u916f\u8fc7\u6ee4\u819c\uff0c\u7ec6\u80de\u4ece\u8fc7\u6ee4\u819c\u8f6c\u79fb\u5230\u8f7d\u73bb\u7247\u4e0a\u76f4\u5f8420mm\u7684\u5706\u5f62\u533a\u57df\u5185\u30022.SurePath\u2122\uff08BD Diagnostics\uff09\uff1a\u901a\u8fc7\u524d\u671f\u6837\u672c\u5904\u7406\u540e\uff0c\u7531\u8ba1\u7b97\u673a\u63a7\u5236\u7684\u62bd\u5438\u7cfb\u7edf\u548c\u79bb\u5fc3\u673a\u5c06\u7ec6\u80de\u56fa\u5b9a\u5728\u8f7d\u73bb\u7247\u4e0a\u7684\u76f4\u5f8412.5mm\u7684\u5706\u5f62\u533a\u57df\u5185\u3002\u4f20\u7edf\u6d82\u7247\uff1a\u5c06\u7ec6\u80de\u6db2\u4f53\u6807\u672c\u76f4\u63a5\u6d82\u5728\u8f7d\u73bb\u7247\u3002<\/p>\n
\u6837\u672c\u6ee1\u610f\u5ea6<\/p>\n
\u4e0d\u6ee1\u610f\uff1a\u8be5\u7c7b\u522b\u5305\u62ec\uff1a<\/p>\n
\uff081\uff09\u62d2\u6536\/\u672a\u5904\u7406\u7684\u6807\u672c\uff1b<\/p>\n
\uff082\uff09\u5df2\u5904\u7406\u548c\u9605\u7247\u4f46\u4e0d\u80fd\u6ee1\u610f\u8bc4\u4f30\u4e0a\u76ae\u5f02\u5e38\u7684\u6807\u672c\uff0c\u540e\u8005\u4e3a\u4e34\u5e8a\u6700\u5e38\u89c1\u7684\u60c5\u51b5\u3002<\/p>\n
\u6807\u51c6\uff1a\u5177\u6709\u6b63\u5e38\u5bab\u9888\u89e3\u5256\u7ed3\u6784\u7684\u5973\u6027\u6837\u672c\u5e94\u5f53\u81f3\u5c11\u67095,000\u4e2a\uff08LBP\uff09\u62168,000~12,000\u4e2a\u663e\u793a\u548c\u4fdd\u5b58\u826f\u597d\u7684\u9cde\u72b6\u6216\u9cde\u5316\u7ec6\u80de\u3002\u7c97\u7565\u4f30\u7b97\u7ec6\u80de\u6570\u91cf\u7684\u65b9\u6cd5\uff1aThinPrep\uff0c100\u4e2a10\u500d\u89c6\u91ce\u4e2d\uff0c50\u4e2a\u7ec6\u80de\/\u89c6\u91ce\uff0c\u621650\u4e2a10\u500d\u89c6\u91ce\u4e2d\uff0c1,600\u4e2a\u7ec6\u80de\/\u89c6\u91ce\uff1bSurePath\uff0c42\u4e2a10\u500d\u89c6\u91ce\u4e2d\uff0c118\u4e2a\u7ec6\u80de\/\u89c6\u91ce\uff0c\u6216118\u4e2a10\u500d\u89c6\u91ce\u4e2d\uff0c676\u4e2a\u7ec6\u80de\/\u89c6\u91ce\u3002\u62a5\u544a\u4e2d\u8fd8\u5e94\u5305\u62ec\u662f\u5426\u5b58\u5728\u5bab\u9888\u7ba1\/\u79fb\u884c\u533a\uff08EC\/TZ\uff09\u6210\u5206\u3002\u8d85\u8fc775%\u7684\u9cde\u72b6\u4e0a\u76ae\u7ec6\u80de\u7531\u4e8e\u65e0\u6cd5\u6e05\u6670\u8bc6\u522b\u800c\u8bc4\u4f30\u4e3a\u4e0d\u6ee1\u610f\u3002\u62a5\u544a\u4e2d\u5e94\u5f53\u8bf4\u660e\u662f\u7531\u4e8e\u8840\u6db2\u3001\u7c98\u6db2\u3001\u6da6\u6ed1\u5242\u3001\u708e\u75c7\u3001\u5236\u7247\u6280\u672f\u6216\u8005\u4ec5\u7531\u4e8e\u7ec6\u80de\u6570\u91cf\u4e0d\u8db3\u800c\u4f7f\u6807\u672c\u4e0d\u6ee1\u610f\u3002<\/p>\n
CAP\u516c\u5e03\u7684\u7f8e\u56fd\u5b9e\u9a8c\u5ba4\u4e2d\u6807\u672c\u4e0d\u6ee1\u610f\u62a5\u544a\u7684\u4e2d\u4f4d\u6570\uff1a2006\u5e741.0%\uff08CP\uff09\u30011.1%\uff08ThinPrep\uff09\u548c0.3%\uff08SurePath\uff09\uff0c2022\u5e741.1%\uff08CP\uff09\u30011.6%\uff08ThinPrep\uff09\u548c0.3%\uff08SurePath\uff09\u30022019\u5e74ASCCP\u57fa\u4e8e\u98ce\u9669\u7684\u7ba1\u7406\u6307\u5357\u66f4\u65b0\u5efa\u8bae\u5bf9\u4e8e\u4e0d\u6ee1\u610f\u6807\u672c\uff0c\u5e94\u57282~4\u4e2a\u6708\u540e\u91cd\u590d\u7ec6\u80de\u5b66\u68c0\u67e5\u3002\u5bf9\u4e8e\u8fde\u7eed\u4e24\u6b21\u7ec6\u80de\u5b66\u68c0\u67e5\u6807\u672c\u4e0d\u6ee1\u610f\u7684\uff0c\u6216\u5df2\u77e5HPV16\/18\u9633\u6027\u4f46\u7ec6\u80de\u5b66\u68c0\u67e5\u6807\u672c\u4e0d\u6ee1\u610f\u7684\u5987\u5973\uff0c\u63a8\u8350\u9634\u9053\u955c\u68c0\u67e5\u3002\u5bf9\u4e8e\u63a5\u53d7\u8fc7\u653e\u7597\u3001\u5316\u7597\u3001\u5b50\u5bab\u5207\u9664\u672f\u6216\u5bab\u9888\u5207\u9664\u672f\u7684\u5987\u5973\uff0c\u5e38\u51fa\u73b0\u5bab\u9888\u72ed\u7a84\u6216\u840e\u7f29\uff0c\u53ef\u4ee5\u8003\u8651\u63a5\u53d72000\u4e2a\u7ec6\u80de\u6570\u7684\u8f83\u4f4e\u9608\u503c\u3002<\/p>\n
\u5224\u8bfb\/\u7ed3\u679c<\/p>\n
\u65e0\u4e0a\u76ae\u5185\u75c5\u53d8\u6216\u6076\u6027\u75c5\u53d8\uff08NILM\uff09<\/p>\n
\u7531\u4e8e\u5bab\u9888\u7ec6\u80de\u5b66\u68c0\u67e5\u7684\u4e3b\u8981\u76ee\u7684\u662f\u7b5b\u67e5\u9cde\u764c\u6216\u5176\u764c\u524d\u75c5\u53d8\uff0c\u8fd9\u4e00\u7c7b\u522b\u5305\u542b\u4e86\u5e7f\u6cdb\u7684\u975e\u80bf\u7624\u6027\u75c5\u53d8\uff0c\u5982\u708e\u75c7\uff08\u6dcb\u5df4\u7ec6\u80de\u6027\u5bab\u9888\u708e\u7b49\uff09\u3001\u751f\u7406\u6027\u6539\u53d8\uff08\u5b50\u5bab\u5185\u819c\u7ec6\u80de\u3001\u840e\u7f29\u3001\u5316\u751f\u3001\u89d2\u5316\u6027\u6539\u53d8\u7b49\uff09\u3001\u5316\u5b66\/\u7269\u7406\u635f\u4f24\u6216\u8005\u6fc0\u7d20\u6027\u6539\u53d8\uff08\u598a\u5a20\u76f8\u5173\u6539\u53d8\u3001\u5b9a\u690d\u6216\u4f20\u67d3\u6027\u75c5\u6bd2\/\u7ec6\u83cc\/\u771f\u83cc\u3001\u5bab\u5185\u8282\u80b2\u5668\u7b49\uff0c\u56fe1\uff09\u3002<\/p>\n<\/p>\n
\u56fe1 \u771f\u83cc\u611f\u67d3\u6240\u81f4\u7684\u201c\u70e4\u8089\u4e32\u201d\u7ec6\u80de\u5f62\u6001<\/p>\n
\uff08a\uff09\u6ef4\u866b\u611f\u67d3\uff0c\uff08b\uff09\u5047\u4e1d\u9175\u6bcd\u83cc\u611f\u67d3\uff0c\u5b62\u5b50\uff0c\uff08c\uff09\u83cc\u4e1d<\/p>\n
\u5982\u524d\u6240\u8ff0\uff0c\u8be5\u7c7b\u522b\u4e2d\u8131\u843d\u7684\u5b50\u5bab\u5185\u819c\uff08\u56fe2\uff09\u662f\u6b63\u5e38\u751f\u7406\u73b0\u8c61\uff0c\u4f46\u662f\u5bf9\u4e8e45\u5c81\u4ee5\u4e0a\u7684\u5987\u5973\uff0c\u8981\u6c42\u62a5\u544a\u5b50\u5bab\u5185\u819c\u7ec6\u80de\u7684\u5b58\u5728\u3002\u4e00\u9879Meta-analysis\u7814\u7a76\u663e\u793a\uff0c\u7ec6\u80de\u5b66\u68c0\u67e5\u53d1\u73b0\u5b50\u5bab\u5185\u819c\u7ec6\u80de\u768440\u5c81\u4ee5\u4e0a\u5987\u5973\uff0c\u6d3b\u68c0\u8bc1\u5b9e\u4e3a\u5b50\u5bab\u5185\u819c\u589e\u751f\u548c\u764c\u7684\u98ce\u9669\u5206\u522b\u4e3a12%\u548c6%\uff0c\u5e94\u75282001\u5e74TBS\u62a5\u544a\u540e\uff0c\u8be5\u98ce\u9669\u964d\u4f4e\u81f32%\u548c1.1%\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63d0\u5347\u62a5\u544a\u5b50\u5bab\u5185\u819c\u7ec6\u80de\u7684\u9884\u6d4b\u4ef7\u503c\uff0c2014\u7248TBS\u5c06\u62a5\u544a\u5e74\u9f84\u8c03\u6574\u81f345\u5c81\u4ee5\u4e0a\u3002<\/p>\n<\/p>\n
\u56fe2 \u6b63\u5e38\u5b50\u5bab\u5185\u819c\u7ec6\u80de\u7c07\u5f62\u6210\u4e09\u7ef4\uff08a\uff09\u6216\u817a\u4f53\u6837\uff08b\uff09\u7ed3\u6784<\/p>\n
\u7f8e\u56fd14~59\u5c81\u5973\u6027HPV\u7684\u603b\u9633\u6027\u738742.5%\uff08\u9ad8\u5371\u578b29%\uff0c\u4f4e\u5371\u578b28.5%\uff09\u3002\u4e00\u9879\u5bf9\u5168\u74031,016,719\u540d\u7ec6\u80de\u5b66\u68c0\u67e5\u7ed3\u679c\u6b63\u5e38\u7684\u5973\u6027\u8fdb\u884cHPV\u68c0\u6d4b\u7684Meta-analysis\u7814\u7a76\u663e\u793a\uff0c\u5176HPV\u9633\u6027\u7387\u4e3a11.7%\u3002\u5728\u7ec6\u80de\u5b66\u68c0\u67e5\u6b63\u5e38\u7684\u5973\u6027\u4e2d\uff0c\u6700\u5e38\u89c1\u7684HPV\u611f\u67d3\u7c7b\u578b\u5982\u4e0b\uff1aHPV16\uff083.2%\uff09\u3001HPV18\uff081.4%\uff09\u3001HPV52\uff080.9%\uff09\u3001HPV31\uff080.8%\uff09\u3001HPV58\uff080.7%\uff09\u300230\u5c81\u4ee5\u4e0a\u7ec6\u80de\u5b66\u68c0\u67e5\u9634\u6027\u7684\u5973\u6027HPV\u9633\u6027\u7387\u57283.4~8.2%\u4e4b\u95f4\uff0c\u7ec6\u80de\u5b66\u9634\u602730\u5c81\u4ee5\u4e0b\u7684\u5973\u6027hrHPV\u7684\u68c0\u51fa\u7387\u8f83\u9ad8\uff088.0%\uff09\uff0c\u4f4630\u5c81\u4ee5\u4e0a\u7684\u4ec5\u4e3a1.9%\uff08490\/25259\u4f8b\uff09\u3002<\/p>\n
2019\u5e74ASCCP\u57fa\u4e8e\u98ce\u9669\u7684\u7ba1\u7406\u6307\u5357\u6307\u51fa\uff0cHPV\u9633\u6027\u4e14\u7ec6\u80de\u5b66\u6b63\u5e38\u7684\u5973\u6027\u7684\u5373\u65f6\u98ce\u9669\u4e3a2.1%\uff0c\u5efa\u8bae\u4e00\u5e74\u540e\u968f\u8bbf\uff0c\u4f46\u7ec6\u80de\u5b66\u6b63\u5e38HPV16\/18\u9633\u6027\u65f6\u5219\u5e94\u8003\u8651\u9634\u9053\u955c\u68c0\u67e5\u3002<\/p>\n
\u610f\u4e49\u4e0d\u660e\u786e\u7684\u975e\u5178\u578b\u9cde\u72b6\u4e0a\u76ae\u7ec6\u80de\uff08ASC-US\uff09<\/p>\n
ASC-US\u662f\u975e\u5178\u578b\u9cde\u72b6\u4e0a\u76ae\u7ec6\u80de\uff08ASC\uff09\u5206\u7c7b\u672f\u8bed\u4e4b\u4e00\uff0c\u5360ASCs\u768490%\uff0c\u8868\u793a\u53ef\u80fd\u5b58\u5728LSIL\u75c5\u53d8\uff0c\u4f46\u662f\u8bc1\u636e\u5c1a\u4e0d\u5145\u5206\uff0c\u4f46\u9ad8\u8fbe10~20%\u7684\u7ec6\u80deASC-US\u4e14HPV\u9633\u6027\u7684\u5973\u6027\uff0c\u5176\u7ec4\u7ec7\u5b66\u968f\u8bbf\u53d1\u73b0\u9ad8\u7ea7\u75c5\u53d8\u3002\u8bca\u65adASC-US\u7684\u4e09\u4e2a\u7ec6\u80de\u5b66\u7279\u5f81\u4e3a\uff1a\u6838\u589e\u5927\u3001\u6838\u8d28\u6bd4\u589e\u52a0\u3001\u6838\u7684\u8f7b\u5fae\u6539\u53d8\uff08\u67d3\u8272\u8d28\u589e\u591a\u3001\u7c97\u9897\u7c92\u3001\u4e0d\u89c4\u5219\u3001\u6a21\u7cca\u3001\u591a\u6838\u7b49\uff0c\u56fe3\uff09\u3002<\/p>\n
\u56fe3 ASC-US\uff0c\u7ec6\u80de\u6838\u589e\u5927\uff0c\u67d3\u8272\u8d28\u5300\u7ec6\uff0c\u6838\u819c\u5149\u6ed1\uff08a~d\uff09\uff0ca\u4e2d\u4f34\u5047\u4e1d\u9175\u6bcd\u83cc\u611f\u67d3<\/p>\n
ASC-US\u7684\u8bca\u65ad\u76f8\u5bf9\u4e3b\u89c2\uff0c\u91cd\u590d\u6027\u8f83\u5dee\u3002\u975e\u5178\u578b\u6027\u89d2\u5316\u4e0d\u5168\u6216\u4e0d\u5b8c\u5168\u6316\u7a7a\u5316\u7ec6\u80de\u53ef\u62a5\u544a\u4e3aASC-US\u3002<\/p>\n
CAP\u516c\u5e03\u7684\u7f8e\u56fd\u5b9e\u9a8c\u5ba4ASC-US\u62a5\u544a\u4e2d\u4f4d\u6570\uff1a2006\u5e742.4%\uff08CP\uff09\u30014.9%\uff08ThinPrep\uff09\u548c4.1%\uff08SurePath\uff09\uff0c2022\u5e741.7%\uff08CP\uff09\u30015.4%\uff08ThinPrep\uff09\u548c4.7%\uff08SurePath\uff09\u3002\u6587\u732e\u62a5\u9053\u7ec6\u80de\u5b66ASC-US\u5973\u6027\u7684hrHPV\u611f\u67d3\u7387\u4e3a31.2~34.5%\u3002CAP\u8c03\u67e5\u6570\u636e\u663e\u793a\uff0c50%\u7684\u5b9e\u9a8c\u5ba4\u62a5\u544a\u7684ASC-US\u5987\u5973hrHPV\u9633\u6027\u7387\u4e3a36.6%\uff0c\u4f4621%\u7684\u5b9e\u9a8c\u5ba4\u62a5\u544a\u7684\u9633\u6027\u7387\u4f4e\u4e8e25%\u3002ASC-US\/LSIL\u5206\u6d41\u7814\u7a76\uff08ALTS\uff09\u4e2d\uff0c\u7ec6\u80de\u5b66ASC-US\u7684hrHPV\u611f\u67d3\u7387\u4e3a48%\uff0cCervista HPV HR\u6d4b\u8bd5\u7684III\u671f\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0chrHPV\u611f\u67d3\u7387\u4e3a57.1%\u3002\u7ec6\u80de\u5b66ASC-US\u4e14hrHPV DNA\u9633\u6027\u7684\u5973\u6027\uff0c\u7ec4\u7ec7\u5b66\u968f\u8bbf\u4e3aCIN2\/3\u7684\u6982\u7387\u57284.3-26.7%\u4e4b\u95f4\u3002\u6839\u636e2019\u5e74ASCCP\u57fa\u4e8e\u98ce\u9669\u7684\u7ba1\u7406\u6307\u5357\uff0cHPV\u9633\u6027\u7ec6\u80de\u5b66ASC-US\u7684CIN3 \u5373\u65f6\u98ce\u9669\u4e3a4.5%\uff0c\u5efa\u8bae\u9634\u9053\u955c\u68c0\u67e5\uff0cHPV\u9634\u6027\u7ec6\u80de\u5b66ASC-US\uff0c\u75c5\u53f2\u672a\u77e5\u8005\u53ef\u4ee5\u4e09\u5e74\u540e\u590d\u67e5\uff08CIN3 \u76845\u5e74\u671f\u98ce\u9669\u4e3a0.40%\uff09\u3002<\/p>\n
\u975e\u5178\u578b\u9cde\u72b6\u4e0a\u76ae\u7ec6\u80de\uff0c\u4e0d\u9664\u5916HSIL\uff08ASC-H\uff09<\/p>\n
ASC-H\u5728ASCs\u4e2d\u76f8\u5bf9\u8f83\u5c11\uff0c\u536010%\uff0c\u63d0\u793aHSIL\u7684\u7ec6\u80de\u5b66\u6539\u53d8\u3002ASC-H\u7684\u4e24\u79cd\u5e38\u89c1\u7ec6\u80de\u5b66\u6a21\u5f0f\u5305\u62ec\u975e\u5178\u578b\u4e0d\u6210\u719f\u5316\u751f\u7ec6\u80de\u548c\u62e5\u6324\u7684\u7247\u72b6\u7ec6\u80de\uff0c\u8868\u73b0\u4e3a\u6838\u8d28\u6bd4\u589e\u52a0\u7684\u5c0f\u7ec6\u80de\u5f62\u6001\u3002<\/p>\n
\u56fe4 ASC-H\uff0c\u7ec6\u80de\u6838\u589e\u5927\uff0c\u6838\u8d28\u6bd4\u9ad8\uff08a~d\uff09<\/p>\n
\u975e\u5178\u578b\u4e0d\u6210\u719f\u5316\u751f\u7ec6\u80de\u6a21\u5f0f\u7684\u8bca\u65ad\u6807\u51c6\u4e3a\u5355\u4e2a\u6563\u5728\u6216\u5c0f\u7c07\u7684\u5316\u751f\u7ec6\u80de\uff0c\u7ec6\u80de\u6838\u9762\u79ef\u662f\u6b63\u5e38\u7ec6\u80de\u76841.5~2.5\u500d\u3002\u62e5\u6324\u7684\u7247\u72b6\u7ec6\u80de\u6a21\u5f0f\u8bca\u65ad\u6807\u51c6\u4e3a\u62e5\u6324\u7684\u9cde\u72b6\u4e0a\u76ae\uff0c\u7ec6\u80de\u6838\u96be\u4ee5\u89c2\u5bdf\uff0c\u7ec6\u80de\u8d28\u6d53\u539a\uff0c\u7ec6\u80de\u5448\u591a\u8fb9\u5f62\uff08\u56fe4\uff09\u3002<\/p>\n
CAP\u516c\u5e03\u7684\u7f8e\u56fd\u5b9e\u9a8c\u5ba4ASC-H\u62a5\u544a\u4e2d\u4f4d\u6570\uff1a2006\u5e740.2%\uff08CP\uff09\u30010.3%\uff08ThinPrep\uff09\u548c0.3%\uff08SurePath\uff09\uff0c2022\u5e740.1%\uff08CP\uff09\u30010.4%\uff08ThinPrep\uff09\u548c0.3%\uff08SurePath\uff09\u3002Magee\u5987\u5973\u533b\u9662\u548cALTS\u6570\u636e\u62a5\u544a\u7684ASC-H\u60a3\u8005\u4e2dhrHPV\u9633\u6027\u7387\u5206\u522b\u4e3a33.3%\u548c85.6%\u4e4b\u95f4\uff0c\u5dee\u522b\u5f88\u5927\uff0c\u5927\u591a\u6570\u7814\u7a76\u62a5\u9053\u5e73\u5747\u4e3a55%\u3002\u6839\u636e2019\u5e74ASCCP\u6307\u5357\uff0c\u7ec6\u80de\u5b66ASC-H\u5973\u6027CIN3 \u7684\u5373\u65f6\u98ce\u9669>25%\uff0c\u660e\u663e\u9ad8\u4e8e4%\u7684\u9608\u503c\u3002\u6b64\u5916\uff0c\u5bf9\u4e8eHPV\u9633\u6027\u7ec6\u80de\u5b66ASC-H\u8005\uff0cCIN2 \u548cCIN3 \u7684\u5373\u65f6\u98ce\u9669\u5206\u522b\u589e\u52a0\u523050%\u548c26%\u3002HPV\u9633\u6027\u548c\u9634\u6027\u65f6\uff0cASC-H\u7684CIN3 \u98ce\u9669\u6709\u5f88\u5927\u4e0d\u540c\uff0cHPV\u9633\u6027\u8005CIN3 \u98ce\u9669\u4e3a26%\uff0c\u764c\u75c7\u98ce\u9669\u4e3a0.92%\uff0cHPV\u9634\u6027\u8005\u5206\u522b\u4e3a3.4%\u548c0.69%\u3002<\/p>\n
\u867d\u7136ASCCP\u6307\u5357\u5efa\u8bae\u5bf9ASC-H\u5987\u5973\u884c\u9634\u9053\u955c\u68c0\u67e5\uff0c\u4f46\u7f8e\u56fd\u5f88\u591a\u533b\u9662\u5bf9ASC-H\u4ecd\u8fdb\u884cHPV\u53cd\u9988\u6027\u68c0\u67e5\uff0c\u5982HPV\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9634\u6027\uff0c\u53ef\u8003\u8651\u884c\u5bab\u9888\u7ec6\u80de\u5b66\u548cHPV\u68c0\u6d4b\u968f\u8bbf\u3002<\/p>\n
\u9ad8\u7ea7\u522b\u9cde\u72b6\u4e0a\u76ae\u5185\u75c5\u53d8\uff08HSIL\uff09<\/p>\n
HSIL\u7ec6\u80de\u4e00\u822c\u8f83\u5c0f\uff0c\u7ec6\u80de\u8d28\u6210\u719f\u5ea6\u8f83\u4f4e\uff0c\u6838\u8d28\u6bd4\u663e\u8457\u589e\u52a0\uff0c\u65e0\u660e\u663e\u7684\u7ec6\u80de\u8d28\uff0c\u6838\u819c\u6781\u5ea6\u4e0d\u89c4\u5219\uff0c\u5e38\u89c1\u660e\u663e\u51f9\u8ff9\uff0c\u7ec6\u80de\u6838\u6df1\u67d3\u3002\u7ec6\u80de\u5b66\u4e2d\u6709\u51e0\u79cdHSIL\u7591\u96be\u5224\u8bfb\u6a21\u5f0f\uff1a\u5408\u80de\u4f53\u6837\u7ec6\u80de\u805a\u96c6\/\u6838\u6df1\u67d3\u62e5\u6324\u7684\u7ec6\u80de\u56e2\u3001\u7d2f\u53ca\u817a\u4f53\u3001\u8c8c\u4f3c\u5b50\u5bab\u5185\u819c\u7ec6\u80de\u548c\u4fee\u590d\u7ec6\u80de\u6a21\u5f0f\u3001\u5355\u4e2a\u548c\u7a00\u5c11\u7684\u5c0f\u578bHSIL\u7ec6\u80de\u3001\u89d2\u5316\u6027HSIL\u3001\u840e\u7f29\u6027HSIL\u4ee5\u53ca\u5177\u6709HSIL\u7279\u5f81\u7684LSIL\uff08\u56fe5\uff09\u3002<\/p>\n
\u56fe5 HSIL\uff0c\u9ad8\u6838\u8d28\u6bd4\uff0c\u6838\u6df1\u67d3\uff0c\u5076\u89c1\u6563\u5728\u7684\u5355\u4e2a\u7ec6\u80de\uff08a~d\uff09<\/p>\n
CAP\u516c\u5e03\u7684\u7f8e\u56fd\u5b9e\u9a8c\u4e2dHSIL\u62a5\u544a\u4e2d\u4f4d\u6570\uff1a2006\u5e740.3%\uff08CP\uff09\u30010.6%\uff08ThinPrep\uff09\u548c0.3%\uff08SurePath\uff09\uff1b2022\u5e740.2%\uff08CP\uff09\u30010.4%\uff08ThinPrep\uff09\u548c0.3%\uff08SurePath\uff09\u3002<\/p>\n
\u52a0\u5dde\u51ef\u6492\u533b\u7597\u96c6\u56e2\uff08KPNC\uff092010\u5e74\u7684\u7814\u7a76\u663e\u793a\uff0c\u7ec6\u80de\u5b66HSIL\u768430\u5c81\u53ca\u4ee5\u4e0a\u5973\u6027hrHPV\u9633\u6027\u7387\u4e3a92.2%\uff0c\u5339\u5179\u5821\u5927\u5b66Magee\u5987\u5973\u533b\u9662\u6570\u636e\u663e\u793a\uff0c\u7ec6\u80de\u5b66HSIL\u7684hrHPV\u603b\u9633\u6027\u7387\u4e3a95.7%\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u52a0\u7565\u6709\u4e0b\u964d\u3002\u603b\u4e4b\uff0c\u7ec6\u80de\u5b66HSIL\u8005\u9700\u8981\u7acb\u5373\u8fdb\u884c\u4e34\u5e8a\u6cbb\u7597\u3002\u5bf9\u4e8e25\u5c81\u6216\u4ee5\u4e0a\u7684\u975e\u598a\u5a20\u60a3\u8005\uff0c\u7ec6\u80de\u5b66HSIL\u4e14HPV16\u9633\u6027\u65f6\uff0cCIN3 \u7684\u5373\u65f6\u98ce\u9669\u226560%\uff0c\u9996\u9009\u7acb\u5373\u4e34\u5e8a\u6cbb\u7597\u3002\u5bf9\u4e8e\u7ec6\u80de\u5b66HSIL\uff0cHPV16\/18\u9634\u6027\u4e14\u9634\u9053\u955c\u68c0\u67e5\u7ed3\u679c\u5b8c\u5168\u6b63\u5e38\u7684\u60a3\u8005\uff0c\u4e0d\u5efa\u8bae\u8fdb\u884c\u968f\u673a\u591a\u70b9\u6d3b\u68c0\u3002\u6839\u636e2019\u5e74ASCCP\u7684\u7ba1\u7406\u6307\u5357\uff0c\u8fd9\u7c7b\u60a3\u8005\u53ef\u8fdb\u884c\u975e\u6d3b\u68c0\u6027\u968f\u8bbf\u3002<\/p>\n
\u975e\u5178\u578b\u817a\u7ec6\u80de\uff08AGC\uff09<\/p>\n
\u7ec6\u80de\u5b66\u68c0\u67e5\u7684\u76ee\u7684\u5e76\u975e\u4e3b\u8981\u7b5b\u67e5\u817a\u7684\u75c5\u53d8\uff0c\u56e0\u4e3a\u53d6\u6837\u56f0\u96be\uff0c\u800c\u4e14\u7075\u654f\u5ea6\u6709\u9650\u3002\u8fd9\u4e00\u7c7b\u522b\u5305\u62ec\uff1a<\/p>\n
\uff081\uff09\u975e\u5178\u578b-\u5bab\u9888\u7ba1\u817a\u7ec6\u80de\uff1b<\/p>\n
\uff082\uff09\u975e\u5178\u578b-\u5b50\u5bab\u5185\u819c\u817a\u7ec6\u80de\uff1b<\/p>\n
\uff083\uff09\u975e\u5178\u578b-\u817a\u7ec6\u80de\uff1b<\/p>\n
\uff084\uff09\u975e\u5178\u578b-\u5bab\u9888\u7ba1\u817a\u7ec6\u80de\uff0c\u503e\u5411\u4e8e\u80bf\u7624\uff1b<\/p>\n
\uff085\uff09\u975e\u5178\u578b-\u817a\u7ec6\u80de\uff0c\u503e\u5411\u4e8e\u80bf\u7624\uff1b<\/p>\n
\uff086\uff09\u5bab\u9888\u7ba1\u539f\u4f4d\u817a\u764c\uff1b<\/p>\n
\uff087\uff09\u817a\u764c\uff0c\u5bab\u9888\u7ba1\u6216\u5bab\u5185\u819c\uff0c\u6216\u5b50\u5bab\u5916\u6216NOS\uff08\u56fe6\uff09\u3002<\/p>\n
CAP\u516c\u5e03\u7684\u7f8e\u56fd\u5b9e\u9a8c\u5ba4AGC\u62a5\u544a\u7684\u4e2d\u4f4d\u6570\u60c5\u51b5\uff1a2006\u5e74\u548c2022\u5e74\u5747\u4e3a0.1%\uff08CP\uff09\u30010.2%\uff08ThinPrep\uff09\u548c0.2%\uff08SurePath\uff09\u3002<\/p>\n
\u975e\u5178\u578b\u5bab\u9888\u7ba1\u817a\u7ec6\u80de\u4e00\u4e2a\u91cd\u590d\u6027\u5f88\u5dee\u7684\u5224\u8bfb\u7c7b\u522b\u3002\u5224\u8bfb\u6807\u51c6\u5305\u62ec\uff1a\u817a\u7ec6\u80de\u62e5\u6324\u3001\u6838\u91cd\u53e0\u548c\u589e\u5927\uff08\u662f\u6b63\u5e38\u5bab\u9888\u7ba1\u7ec6\u80de\u76843~5\u500d\uff09\u3001\u5076\u89c1\u6838\u4ec1\u548c\u7f55\u89c1\u7684\u6838\u5206\u88c2\u8c61\u3002\u975e\u5178\u578b\u5bab\u9888\u7ba1\u817a\u7ec6\u80de\uff0c\u503e\u5411\u4e8e\u80bf\u7624\uff1a\u7ec6\u80de\u5f62\u6001\u5b66\u53d8\u5316\u65e0\u8bba\u5728\u91cf\u548c\u8d28\u4e0a\u5747\u4e0d\u8db3\u4ee5\u5224\u8bfb\u4e3a\u5bab\u9888\u7ba1\u539f\u4f4d\u817a\u764c\u6216\u6d78\u6da6\u6027\u817a\u764c\uff0c\u7ec6\u80de\u5448\u73ab\u7470\u82b1\u73af\u6216\u817a\u4f53\u6837\u7ed3\u6784\uff0c\u6838\u8d28\u6bd4\u589e\u52a0\uff0c\u6838\u62e5\u6324\/\u5047\u590d\u5c42\uff0c\u6838\u589e\u5927\uff0c\u67d3\u8272\u8d28\u589e\u591a\uff0c\u5076\u89c1\u6838\u5206\u88c2\u3002\u975e\u5178\u578b\u5b50\u5bab\u5185\u819c\u817a\u7ec6\u80de\u548c\u503e\u5411\u4e8e\u80bf\u7624\u7684\u53ef\u91cd\u590d\u6027\u8f83\u5dee\uff0c\u826f\u6027\u4e0e\u975e\u5178\u578b\u5b50\u5bab\u5185\u819c\u817a\u7ec6\u80de\u5f62\u6001\u5b66\u7684\u533a\u522b\u4e3b\u8981\u57fa\u4e8e\u6838\u589e\u5927\u7684\u7a0b\u5ea6\u3002\u5728\u5224\u8bfb\u975e\u5178\u578b\u5b50\u5bab\u5185\u819c\u7ec6\u80de\u65f6\uff0c\u4e34\u5e8a\u6240\u89c1\u548c\u75c5\u53f2\u5982\u5bab\u5185\u8282\u80b2\u5668\uff0c\u606f\u8089\u7b49\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002\u5bab\u9888\u7ba1\u539f\u4f4d\u817a\u764c\u7684\u5178\u578b\u7ec6\u80de\u5f62\u6001\u7279\u5f81\u4e3a\u67f1\u72b6\u7ec6\u80de\uff0c\u6838\u589e\u5927\uff0c\u67d3\u8272\u8d28\u589e\u591a\u3001\u5f02\u5e38\uff0c\u5047\u590d\u5c42\uff0c\u53ef\u89c1\u6838\u5206\u88c2\uff0c\u65e0\u80bf\u7624\u7d20\u8d28\u3002<\/p>\n
\u56fe6\uff08a\uff09\u5bab\u9888\u7ba1\u539f\u4f4d\u817a\u764c\uff0c\u817a\u7ec6\u80de\u6392\u5217\u7fbd\u6bdb\u72b6\uff08b-c\uff09\u817a\u764c\uff0cNOS\uff1a\u7ec6\u80de\u5f62\u6210\u817a\u4f53\u6837\u7ed3\u6784\uff0c\u6838\u62e5\u6324\u91cd\u53e0\uff0c\u67d3\u8272\u8d28\u589e\u591a\uff08d-f\uff09\u9cde\u764c\uff0c\u6a58\u7ea2\u8272\u80bf\u7624\u7ec6\u80de\uff0c\u4e0d\u89c4\u5219\u7684\u6838\u8f6e\u5ed3\u3001\u6838\u6d53\u67d3\uff0c\u874c\u86aa\u6837\u7279\u5f81\uff0c\u80cc\u666f\u4e3a\u80bf\u7624\u7d20\u8d28<\/p>\n
AGC\u7684hrHPV\u9633\u6027\u7387\u4ecb\u4e8e20~40%\u4e4b\u95f4\u3002KPNC\u62a5\u9053\u768430\u5c81\u4ee5\u4e0a\u5973\u6027\u7684hrHPV\u9633\u6027\u7387\u4e3a21.3%\uff0cMagee\u5987\u5973\u533b\u9662\u4e3a24.3%\uff0875\/309\uff09\uff0c\u4e0eDerchain\u7b49\u4eba\u62a5\u544a\u768429%\u7c7b\u4f3c\u3002\u6b64\u5916\uff0cRabelo-Santos\u7b49\u4eba\u62a5\u544a\uff0c\u5728AGC\u6216AIS\u7684\u5987\u5973\u4e2d\uff0chrHPV\u9633\u6027\u7387\u4e3a43%\uff0cHPV16\u662f\u6700\u5e38\u89c1\u7684\u7c7b\u578b\uff0c\u5176\u6b21\u4e3aHPV18\u3002HPV16\u4e0e\u9cde\u764c\u548c\u817a\u764c\u5747\u663e\u8457\u76f8\u5173\uff0c\u800cHPV18\u4e0e\u817a\u764c\u7684\u76f8\u5173\u6027\u66f4\u5f3a\u3002\u5728Mulem E\u7b49\u4eba\u7684\u7814\u7a76\u4e2d\uff0c20.3%\uff0833\/161\uff09\u7684AGC\u68c0\u6d4b\u5230hrHPV\u9633\u6027\uff0c\u5176\u4e2d8%\u4e3aHPV16\/18\u3002<\/p>\n
\u7ec6\u80de\u5b66AGC\u7684\u7ec4\u7ec7\u5b66\u968f\u8bbf\u60c5\u51b5\u4e3a\uff1aAIS\uff083~4%\uff09\uff0cCIN2 \uff089%\uff09\uff0c\u6d78\u6da6\u6027\u764c\uff082~3%\uff09\u3002AGC\u7684CIN2 \u548cCIN3 \u7684\u5373\u65f6\u98ce\u9669\u5728HPV\u9633\u6027\u65f6\u4e3a40%\u548c26%\uff0cHPV\u9634\u6027\u65f6\u7684CIN3 \u5373\u65f6\u98ce\u9669\u4e3a1.1%\u3002\u5bf9\u4e8e\u975e\u598a\u5a20\u671f\u7684\u6240\u6709\u5e74\u9f84\u6bb5AGC\u548cAIS\u60a3\u8005\uff0c\u9664\u975e\u5178\u578b\u5b50\u5bab\u5185\u819c\u817a\u7ec6\u80de\u4ee5\u5916\uff0c\u65e0\u8bbaHPV\u7ed3\u679c\u5982\u4f55\uff0c\u5747\u5efa\u8bae\u8fdb\u884c\u9634\u9053\u955c\u68c0\u67e5\u548c\u5bab\u9888\u7ba1\u6414\u522e\u3002\u5bf9\u4e8e35\u5c81\u4ee5\u4e0a\u6216\u800535\u5c81\u4ee5\u4e0b\u6709\u5b50\u5bab\u5185\u819c\u764c\u98ce\u9669\u7684\u5973\u6027\uff0c\u4e5f\u5efa\u8bae\u8fdb\u884c\u5b50\u5bab\u5185\u819c\u53d6\u6837\u3002\u5bf9\u4e8e\u6d3b\u68c0\u672a\u53d1\u73b0\u7ec4\u7ec7\u5b66HSIL\u6216\u539f\u4f4d\u817a\u764c\/\u817a\u764c\u7684AGC\u5987\u5973\uff0c\u5efa\u8bae\u4e00\u5230\u4e24\u5e74\u540e\u8fdb\u884c\u8054\u5408\u7b5b\u67e5\uff0c\u5982\u679c\u968f\u8bbf\u7ed3\u679c\u6709\u4efb\u4f55\u5f02\u5e38\uff0c\u5373\u8fdb\u884c\u9634\u9053\u955c\u68c0\u67e5\u3002<\/p>\n
HPV\u68c0\u6d4b<\/p>\n
\u5171\u6709\u8d85\u8fc7140\u591a\u79cdHPV\u4e9a\u578b\u6839\u636e\u5176\u5bf9\u5bab\u9888\u7684\u81f4\u764c\u6027\u88ab\u5206\u4e3a\u9ad8\u5371\u578b\u548c\u4f4e\u5371\u578b\u3002\u76ee\u524d\u67095\u79cdFDA\u6279\u51c6\u7684HPV\u8054\u5408\u548c\u5206\u578b\u68c0\u6d4b\uff1a<\/p>\n
\uff081\uff09HC2 HPV DNA test\uff082001\u5e74\u6279\u51c6\uff09\uff0c\u68c0\u6d4b13\u79cdHPV\uff0816\u300118\u300131\u300133\u300135\u300139\u300145\u300151\u300152\u300156\u300158\u300159\u548c68\uff09\uff1b<\/p>\n
\uff082\uff09Cervista HPV HR test\uff0c\u7528\u4e8e\u68c0\u6d4b14\u79cdhrHPV\u548cCervista HPV16\u300118\/45\u5206\u578b\u68c0\u6d4b\uff08\u73b0\u5df2\u9000\u51fa\u7f8e\u56fd\u5e02\u573a\uff09\uff1b<\/p>\n
\uff083\uff09Cobas 4800 HPV test\uff082011\u5e74\u6279\u51c6\uff09\uff0c\u4e00\u79cd\u57fa\u4e8ehrHPV DNA\u7684PCR\u7b5b\u67e5\u68c0\u6d4b\uff0c\u7528\u4e8e\u4e13\u95e8\u8bc6\u522bHPV16\u548c18\u578b\uff0c\u540c\u65f6\u901a\u8fc7real-time PCRPCR\u68c0\u6d4b\u5176\u4f5912\u4e2a\u9ad8\u5371\u7c7b\u578b\uff0831\u300133\u300135\u300139\u300145\u300151\u300152\u300156\u300158\u300159\u300166\u548c68\uff09\uff1b\uff084\uff09Aptima HPV test\uff082012\u5e74\u6279\u51c6\uff09\uff0c\u7528\u4e8e\u68c0\u6d4b14\u79cdhrHPV\uff0c\u4ee5\u53caAptima HPV16 18\/45\u57fa\u56e0\u5206\u578b\u3002\uff085\uff09Becton Dickinson\u7684Onclarity HPV test\uff0c2018\u6279\u51c6\uff0c\u5e76\u4e8e2020\u5e74\u6279\u51c6\u62d3\u5c55HPV\u57fa\u56e0\u5206\u578b\uff0c\u53ef\u68c0\u6d4bHPV16\u300118\u300145\u300131\u300151\u300152\u300133 58\u300135 39 68\u548c56 59 66\u3002\u5176\u4e2d\u4ec5\u6709Roche Cobas HPV\u68c0\u6d4b\u548cBD Onclarity HPV\u68c0\u6d4b\u83b7FDA\u6279\u51c6\u53ef\u7528\u4e8e\u5bab\u9888\u764c\u4e00\u7ebf\u7b5b\u67e5\u3002<\/p>\n
HPV\u75ab\u82d7\u7b80\u4ecb<\/p>\n
\u201cHeLa\u7ec6\u80de\u201d\u2014\u2014\u4ece\u6b7b\u4e8e\u5bab\u9888\u764c\u7684\u975e\u88d4\u7f8e\u56fd\u5987\u5973Henrietta Lack\u83b7\u5f97\u7684\u4f53\u5916\u6c38\u751f\u5bab\u9888\u764c\u7ec6\u80de\u682a\uff0c\u662fHPV\u75ab\u82d7\u7814\u53d1\u7684\u57fa\u7840\u3002<\/p>\n
\u7f8e\u56fd\u514d\u75ab\u5b9e\u8df5\u54a8\u8be2\u59d4\u5458\u4f1a\u5efa\u8bae\u572811\u621612\u5c81\u65f6\u63a5\u79cdHPV\u75ab\u82d7\u3002\u76ee\u524d\u6709\u4e09\u79cd\u9884\u9632\u6027\u7684HPV\u75ab\u82d7\u5728\u7f8e\u56fd\u83b7\u5f97\u8bb8\u53ef\uff0c\u5747\u7531\u975e\u4f20\u67d3\u6027\u7684\u75c5\u6bd2\u6837\u9897\u7c92\u7ec4\u6210\uff1a\u4e5d\u4ef7\uff089vHPV\uff0cGardasil 9\uff0cMerck&Co.2014\uff09\uff0c\u56db\u4ef7\uff084vHPV\uff0cGardasil\uff0cMerck&Co.2006\uff09\u548c\u4e8c\u4ef7\uff082vHPV\uff0cCervarx\uff0cGlaxoSmithKline\uff0c2007\uff09\u3002\u4e5d\u4ef7\u9488\u5bf9HPV6\u300111\u300116\u300118\u300131\u300133\u300145\u300152\u548c58\uff0c\u56db\u4ef7\u9488\u5bf9HPV6\u300111\u300116\u548c18\uff0c\u4e8c\u4ef7\u4ec5\u9488\u5bf9HPV 16\u548c18\u3002\u4e5d\u4ef7HPV\u75ab\u82d7\u662f\u7f8e\u56fd\u76ee\u524d\u552f\u4e00\u5e94\u7528\u7684\u75ab\u82d7\u4ea7\u54c1\u3002<\/p>\n
HPV\u75ab\u82d7\u5177\u6709\u5f88\u5f3a\u7684\u5b89\u5168\u6027\uff0c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u9664\u4e86\u4e2a\u522b\u62a5\u544a\u4e86\u63a5\u79cd\u75ab\u82d7\u540e\u7684\u8fd0\u52a8\u529f\u80fd\u969c\u788d\uff0c\u4ece\u672a\u51fa\u73b0\u8fc7\u4efb\u4f55\u91cd\u5927\u4e0d\u826f\u4e8b\u4ef6\u30022009\u5e74\uff0cWHO\u9996\u6b21\u5efa\u8bae\u5728\u5168\u7403\u8303\u56f4\u5185\u54119~14\u5c81\u7684\u5973\u5b69\u63a5\u79cdHPV\u75ab\u82d7\u3002HPV\u75ab\u82d7\u53ca\u5176\u5b89\u5168\u6027\u5f97\u5230\u4e86WHO\u548c\u5168\u7403\u75ab\u82d7\u5b89\u5168\u54a8\u8be2\u5c0f\u7ec4\u7684\u8ba4\u53ef\u3002WHO\u5bf9HPV\u75ab\u82d7\u63a5\u79cd\u65f6\u95f4\u7684\u6700\u65b0\u5efa\u8bae\u5982\u4e0b\uff1a<\/p>\n
\uff081\uff099~14\u5c81\uff0c\u4e00\u5230\u4e24\u9488\uff1b<\/p>\n
\uff082\uff0915~20\u5c81\uff0c\u4e00\u5230\u4e24\u9488\uff1b<\/p>\n
\uff083\uff0921\u5c81\u4ee5\u4e0a\uff0c\u4e24\u9488\uff0c\u95f4\u96946\u4e2a\u6708\u3002<\/p>\n
\u8be5\u5efa\u8bae\u7684\u76ee\u7684\u662f\uff0c\u6027\u751f\u6d3b\u5f00\u59cb\u4e4b\u524d\u76849-14\u5c81\u5973\u5b69\u662f\u75ab\u82d7\u63a5\u79cd\u7684\u4e3b\u8981\u76ee\u6807\u4eba\u7fa4\uff0c\u540c\u65f6\u5efa\u8bae\u5728\u53ef\u884c\u6027\u548c\u7ecf\u6d4e\u6761\u4ef6\u5141\u8bb8\u4e0b\uff0c\u4e3a\u7537\u6027\u548c\u8001\u5e74\u5973\u6027\u7b49\u6b21\u8981\u76ee\u6807\u4eba\u7fa4\u8fdb\u884c\u63a5\u79cd\u3002<\/p>\n
\u5c55\u671b<\/p>\n
\u5728\u7f8e\u56fd\u5bab\u9888\u764c\u7b5b\u67e5\u6b63\u5728\u7ecf\u5386\u4ece\u7ec6\u80de\u5b66\u68c0\u67e5\u5230\u8054\u5408\u7b5b\u67e5\u548chrHPV\u4e00\u7ebf\u7b5b\u67e5\u65b9\u6848\u7684\u8f6c\u53d8\u3002\u7136\u800c\uff0c\u7531\u4e8eHPV\u68c0\u6d4b\u7684\u4f4e\u7279\u5f02\u6027\u4ee5\u53caHPV\u9634\u6027\u5bab\u9888\u764c\u7684\u5b58\u5728\uff0c\u5f88\u591a\u5b9e\u9a8c\u5ba4\u4ecd\u7136\u5e94\u7528Aptima\u548cHC2\u68c0\u6d4b\u65b9\u6cd5\uff08FDA\u6ca1\u6709\u8ba4\u8bc1\u7528\u505a\u4e00\u7ebf\u7b5b\u67e5\uff09HPV\uff0c\u6240\u4ee5\uff08HPV\u4e00\u7ebf\u7b5b\u67e5\u4e34\u5e8a\u5e94\u7528\u5f88\u5c11\uff0c\u4f30\u8ba1\u7ea6\u5360\u4e0d\u8db35%\u7684\u5e02\u573a\u3002\u7f8e\u56fd\u5927\u591a\u6570\u533b\u9662\u73b0\u884c\u7684\u7b5b\u67e5\u65b9\u6848\u4ecd\u7136\u4e3a\uff1a\u5f00\u59cb\u7b5b\u67e5\u5e74\u9f84\u4e3a21\u5c81\uff1b21~29\u5c81\uff0c\u4ee5\u7ec6\u80de\u5b66\u68c0\u67e5\u4e3a\u4e3b\uff0cASC-US\u53cd\u9988\u6027HPV\u68c0\u6d4b\uff1b30~65\u5c81\uff0c\u4e3b\u8981\u65b9\u6cd5\u4e3a\u7ec6\u80de\u5b66\u548cHPV\u68c0\u6d4b\u8054\u5408\u7b5b\u67e5\uff0c\u6216\u4ee5\u7ec6\u80de\u5b66\u4e3a\u4e3b\u7684\u7b5b\u67e5\u4e3a\u3002\u6700\u5408\u9002\u7684\u65b9\u6848\u9700\u8981\u4e34\u5e8a\u533b\u751f\u3001\u75c5\u7406\u533b\u751f\u548c\u60a3\u8005\u5171\u540c\u52aa\u529b\uff0c\u9488\u5bf9\u6bcf\u4e2a\u5177\u4f53\u75c5\u4f8b\u8fdb\u884c\u7efc\u5408\u8003\u91cf\u3002[1] Wang T, Zhang H, Liu Y, Zhao C. Updates in Cervical Cancer Screening Guidelines, The Bethesda System for Reporting Cervical Cytology, and Clinical Management Recommendations. J Clin Transl Pathol. Published online: Apr 21, 2023. doi: 10.14218\/JCTP.2023.00004.<\/p>\n
\u539f\u6587\u7b2c\u4e00\u4f5c\u8005<\/p>\n
\u738b\u5929\u5357MD\uff0cPhD<\/p>\n
\u7f8e\u56fd\u5357\u52a0\u5dde\u5927\u5b66Keck\u533b\u5b66\u9662\u75c5\u7406\u7cfb\u52a9\u7406\u6559\u6388<\/p>\n
\u5987\u79d1\uff0c\u4e73\u817a\u75c5\u7406\u548c\u7ec6\u80de\u75c5\u7406\u533b\u751f<\/p>\n
\u4e3b\u8981\u79d1\u7814\u65b9\u5411\uff1a\u5987\u79d1\u6076\u6027\u80bf\u7624\u7684\u8bca\u65ad\u548c\u5206\u7c7b\u3001\u4e73\u817a\u764c\u5987\u79d1\u80bf\u7624\u7684\u751f\u7269\u6807\u8bb0\u3001\u4e73\u817a\u764c\u4e34\u5e8a\u8bca\u65ad\u548c\u6cbb\u7597\u3002<\/p>\n
\u53d1\u8868\u8d8530\u7bc7\u82f1\u6587\u533b\u5b66\u79d1\u7814\u8bba\u6587\uff0c\u53c2\u4e0e\u64b0\u5199\u7ae0\u8282\u201cpathology of the ovary, fallopian tube and peritoneum, springer, 2022.<\/p>\n
\u4e2d\u6587\u7f16\u8bd1<\/p>\n
\u90ed\u6c38\u771fPhD<\/p>\n
\u90d1\u5dde\u5927\u5b66\u7b2c\u4e09\u9644\u5c5e\u533b\u9662\u75c5\u7406\u533b\u751f<\/p>\n
\u4e2d\u6587\u5ba1\u9605 \u539f\u6587\u4f5c\u8005<\/p>\n
\u8d75\u6f84\u6cc9MD<\/p>\n
\u7f8e\u56fd\u5339\u5179\u5821\u5927\u5b66\u533b\u5b66\u9662\u6559\u6388\u5987\u79d1\u3001\u4e73\u817a\u75c5\u7406\u5b66\u548c\u7ec6\u80de\u75c5\u7406\u5b66\u4e13\u5bb6\uff0c\u7ec6\u80de\u75c5\u7406\u5b66\u4e3b\u4efb\u4e2d\u56fd\u9634\u9053\u955c\u53ca\u5bab\u9888\u75c5\u7406\u5b66\u4f1a\uff08CSCCP\uff09\u9996\u5e2d\u6d77\u5916\u533b\u5b66\u987e\u95ee\u4e3b\u8981\u7814\u7a76\u65b9\u5411\uff1a\u5bab\u9888\u764c\u7b5b\u67e5\u3001\u5bab\u9888\u7ec6\u80de\u5b66\u3001HPV\u68c0\u6d4b\u7b49\u5df2\u53d1\u8868\u533b\u5b66\u79d1\u7814\u8bba\u6587220\u7bc7\u3001\u8bba\u6587\u6458\u8981160\u7bc7\uff0c\u4e3b\u7f168\u90e8\u4e2d\u6587\u533b\u5b66\u4e66\u7c4d\u548c\u4e3b\u5ba17\u90e8\u82f1\u6587\u7ffb\u8bd1\u4e66<\/p>\n","protected":false},"excerpt":{"rendered":"
\u5bab\u9888\u764c\u81f3\u4eca\u4ecd\u7136\u662f\u5168\u7403\u6027\u516c\u5171\u536b\u751f\u95ee\u9898\u3002\u4ee5\u4eba\u7fa4\u4e3a\u57fa\u7840\u7684\u764c\u75c7\u65e9\u671f\u7b5b\u67e5\u548c\u9884\u9632\u65b9\u6848\uff0c\u5305\u62ec\u75ab … \u7ee7\u7eed\u9605\u8bfb