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\u4e34\u5e8a\u5e94\u7528\u7b56\u7565\uff1a\u9c81\u7d22\u66ff\u5c3c\u4e73\u818f\u6bcf\u5929\u4f7f\u75282\u6b21\uff0c\u6bcf\u6b21\u4f7f\u7528\u9762\u79ef\u4e0d\u8d85\u8fc7\u4f53\u8868\u9762\u79ef\u768420%\uff0c\u603b\u7528\u91cf\u4e0d\u8d85\u8fc760 g\/\u5468\u6216100 g\/2\u5468\u3002\u8fea\u9ad8\u66ff\u5c3c\u8f6f\u818f\u6bcf\u5929\u4f7f\u75282\u6b21\uff0c\u6bcf\u6b21\u4f7f\u7528\u9762\u79ef\u4e0d\u8d85\u8fc7\u4f53\u8868\u9762\u79ef\u768430%\uff0c\u6bcf\u6b21\u603b\u7528\u91cf\u4e0d\u8d85\u8fc75 g\u30022. \u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u53ca\u7ba1\u7406\uff1a\u9c81\u7d22\u66ff\u5c3c\u4e73\u818f\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387 \u2265 1%\uff0c\u5305\u62ec\u9f3b\u54bd\u708e\u3001\u652f\u6c14\u7ba1\u708e\u7b49\u3002\u4f7f\u7528\u671f\u95f4\u5efa\u8bae\u9632\u6652\uff0c\u5b9a\u671f\u590d\u67e5\u8840\u5e38\u89c4\u3002\u8fea\u9ad8\u66ff\u5c3c\u7684\u4e0d\u826f\u53cd\u5e94\u4e3b\u8981\u5305\u62ec\u6d82\u62b9\u90e8\u4f4d\u7ea2\u6591\u6216\u523a\u6fc0\u6216\u7619\u75d2\u7b49\uff0c\u5927\u591a\u4e0d\u826f\u53cd\u5e94\u8f83\u8f7b\u5fae\u3002\u4f7f\u7528\u671f\u95f4\u82e5\u51fa\u73b0\u6bdb\u56ca\u708e\u3001\u75e4\u75ae\u53ca\u75b1\u75b9\u75c5\u6bd2\u611f\u67d3\u7b49\uff0c\u5219\u505c\u6b62\u5728\u76f8\u5e94\u90e8\u4f4d\u7528\u836f\u5e76\u914c\u60c5\u8fdb\u884c\u6297\u611f\u67d3\u6cbb\u7597\u30023. \u7279\u6b8a\u4eba\u7fa4\u7528\u836f\u7ba1\u7406\u598a\u5a20\u671f\u6216\u54fa\u4e73\u671f\u60a3\u8005\uff1a<\/p>\n<p>\u7f3a\u4e4f\u4e34\u5e8a\u6570\u636e\uff0c\u5efa\u8bae\u5728\u4f7f\u7528\u9c81\u7d22\u66ff\u5c3c\u4e73\u818f\u6cbb\u7597\u671f\u95f4\u53ca\u505c\u75284\u5468\u5185\u907f\u514d\u54fa\u4e73\u3002<\/p>\n<p>\u513f\u7ae5\u60a3\u8005\uff1a<\/p>\n<p>\u9c81\u7d22\u66ff\u5c3c\u4e73\u818f\u572812\u5c81\u4ee5\u4e0b\u513f\u7ae5AD\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u4e0d\u660e\u786e\uff0c\u8fea\u9ad8\u66ff\u5c3c\u8f6f\u818f\u57286\u6708\u9f84\u4ee5\u4e0b\u5a74\u513fAD\u60a3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u5c1a\u4e0d\u660e\u786e\u3002<\/p>\n<p>\u8001\u5e74\u60a3\u8005\uff1a<\/p>\n<p>\u9c81\u7d22\u66ff\u5c3c\u4e73\u818f\u7684\u5e94\u7528\u540c\u6210\u4eba\u60a3\u8005\uff0c\u8fea\u9ad8\u66ff\u5c3c\u8f6f\u818f\u5c1a\u65e0\u4e34\u5e8a\u6570\u636e\u3002<\/p>\n<\/p>\n<p>\u4e8c\u3001AD\u7cfb\u7edf\u836f\u7269\u7684\u5e94\u7528\u7ba1\u7406\uff08\u4e00\uff09\u6297\u7ec4\u80fa\u836f1. \u4e34\u5e8a\u5e94\u7528\u7b56\u7565\uff1a\u5355\u72ec\u4f7f\u7528\u6297\u7ec4\u80fa\u836f\u6cbb\u7597AD\u7597\u6548\u5c1a\u4e0d\u660e\u786e\uff0c\u5e38\u4e0eTCS\u7b49\u5916\u7528\u836f\u7269\u8054\u5408\u4f7f\u7528\u30022. \u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u53ca\u7ba1\u7406\uff1a\u7b2c\u4e00\u4ee3\u6297\u7ec4\u80fa\u836f\u7684\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u55dc\u7761\u3001\u773c\u538b\u5347\u9ad8\u3002\u4e59\u9187\u3001\u9547\u75db\u836f\u3001\u50ac\u7720\u836f\u7b49\u53ef\u52a0\u91cd\u7b2c\u4e00\u4ee3\u53ca\u67d0\u4e9b\u7b2c\u4e8c\u4ee3\u6297\u7ec4\u80fa\u836f\u7684\u4e2d\u67a2\u6291\u5236\u4f5c\u7528\uff0c\u5e94\u907f\u514d\u540c\u65f6\u670d\u7528\u30023. \u7279\u6b8a\u4eba\u7fa4\u7528\u836f\u7ba1\u7406\u598a\u5a20\u671f\/\u54fa\u4e73\u671f\u60a3\u8005\uff1a<\/p>\n<p>\u4e0d\u5efa\u8bae\u598a\u5a20\u671f\u60a3\u8005\u5e38\u89c4\u4f7f\u7528\u6297\u7ec4\u80fa\u836f\uff0c\u5c24\u5176\u907f\u514d\u598a\u5a20\u524d3\u4e2a\u6708\u5185\u4f7f\u7528\u3002\u7528\u836f\u671f\u95f4\u5efa\u8bae\u505c\u6b62\u54fa\u4e73\u3002<\/p>\n<p>\u513f\u7ae5\u60a3\u8005\uff1a<\/p>\n<p>\u5efa\u8bae\u9009\u62e9\u65e0\u4e2d\u67a2\u6291\u5236\u4f5c\u7528\u7684\u4e8c\u4ee3\u6297\u7ec4\u80fa\u836f\u3002<\/p>\n<p>\u8001\u5e74\u60a3\u8005\uff1a<\/p>\n<p>\u5c3d\u91cf\u907f\u514d\u4f7f\u7528\u7b2c\u4e00\u4ee3\u6297\u7ec4\u80fa\u836f\u3002<\/p>\n<p>\u809d\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff1a<\/p>\n<p>\u809d\u529f\u80fd\u4e0d\u5168\u8005\u9996\u9009\u897f\u66ff\u5229\u55ea\u3001\u5de6\u897f\u66ff\u5229\u55ea\u3001\u975e\u7d22\u975e\u90a3\u5b9a\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u7b2c\u4e00\u4ee3\u548c\u90e8\u5206\u7b2c\u4e8c\u4ee3\u6297\u7ec4\u80fa\u836f\u5982\u4f9d\u5df4\u65af\u6c40\u3001\u54aa\u5511\u65af\u6c40\u3001\u6c2f\u96f7\u4ed6\u5b9a\u3001\u5730\u6c2f\u96f7\u4ed6\u5b9a\uff0c\u809d\u529f\u80fd\u4e0d\u5168\u8005\u5728\u4f7f\u7528\u65f6\u5e94\u51cf\u4f4e\u5242\u91cf\uff0c\u4e25\u91cd\u809d\u529f\u80fd\u4e0d\u5168\u8005\u7981\u7528\u54aa\u5511\u65af\u6c40\u3002\u8f7b\u5ea6\u80be\u529f\u80fd\u4e0d\u5168\u8005\u9996\u9009\u4f9d\u5df4\u65af\u6c40\u3001\u975e\u7d22\u975e\u90a3\u5b9a\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u5176\u4ed6\u836f\u7269\u5728\u80be\u529f\u80fd\u4e0d\u5168\u8005\u4e2d\u5e94\u7528\u5747\u9700\u6839\u636e\u80be\u529f\u80fd\u8c03\u6574\u5242\u91cf\uff0c\u4e25\u91cd\u80be\u529f\u80fd\u4e0d\u5168\u8005\u7981\u7528\u897f\u66ff\u5229\u55ea\u3002<\/p>\n<p>\uff08\u4e8c\uff09\u514d\u75ab\u6291\u5236\u5242<\/p>\n<p>1. \u73af\u5b62\u7d20\uff1a&nbsp;<\/p>\n<p>\uff081\uff09\u4e34\u5e8a\u5e94\u7528\u7b56\u7565\uff1a\u63a8\u8350\u8d77\u59cb\u5242\u91cf\u4e3a2.5 ~ 5 mg\u00b7kg<sup>-1<\/sup>\u00b7d<sup>-1<\/sup>\uff0c\u52062\u6b21\u53e3\u670d\uff0c\u75c5\u60c5\u63a7\u5236\u540e\u6bcf2\u5468\u51cf\u5c111 mg\u00b7kg<sup>-1<\/sup>\u00b7d<sup>-1<\/sup>&nbsp;\uff0c\u9010\u6e10\u51cf\u81f3\u6700\u5c0f\u5242\u91cf\uff080.5 ~ 1 mg\u00b7kg<sup>-1<\/sup>\u00b7d<sup>-1<\/sup>\uff09\u7ef4\u6301\u3002\u7597\u7a0b\u5efa\u8bae\u4e0d\u8d85\u8fc71 ~ 2\u5e74\uff0c\u7597\u7a0b\u7ed3\u675f\u540e\u53ef\u8003\u8651\u95f4\u96943 ~ 6\u4e2a\u6708\u540e\u5f00\u59cb\u65b0\u7684\u7597\u7a0b\u3002\uff082\uff09\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u53ca\u7ba1\u7406\uff1a\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u9ad8\u8840\u538b\u548c\u80be\u6bd2\u6027\u3002\u5b9a\u671f\u76d1\u6d4b\u8840\u538b\u3002(3) \u7279\u6b8a\u4eba\u7fa4\u7528\u836f\u7ba1\u7406\u598a\u5a20\u671f\/\u54fa\u4e73\u671f\u60a3\u8005\uff1a<\/p>\n<p>\u5c1a\u65e0\u598a\u5a20\u671f\u4e34\u5e8a\u6570\u636e\uff0c\u4f7f\u7528\u524d\u5e94\u5145\u5206\u6743\u8861\u5229\u5f0a\u3002\u9700\u957f\u671f\u7cfb\u7edf\u6cbb\u7597\u7684\u91cd\u5ea6AD\u5b55\u5987\uff0c\u73af\u5b62\u7d20\u662f\u4e00\u7ebf\u9009\u62e9\u3002\u7528\u836f\u671f\u95f4\u4e0d\u5b9c\u54fa\u4e73\u3002<\/p>\n<p>\u513f\u7ae5\u60a3\u8005\uff1a<\/p>\n<p>\u8d85\u9002\u5e94\u8bc1\u5e94\u7528\uff0c\u5e94\u5145\u5206\u6743\u8861\u5229\u5f0a\uff0c\u614e\u91cd\u4f7f\u7528\u3002<\/p>\n<p>\u8001\u5e74\u60a3\u8005\uff1a<\/p>\n<p>\u53d1\u751f\u6076\u6027\u80bf\u7624\u548c\u5668\u5b98\u6bd2\u6027\u7684\u98ce\u9669\u589e\u52a0\uff0c\u4e0d\u5efa\u8bae\u4f7f\u7528\u3002<\/p>\n<p>\u809d\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff1a<\/p>\n<p>\u4e0d\u5efa\u8bae\u4f7f\u7528\u3002<\/p>\n<p>\u75ab\u82d7\u63a5\u79cd\u8005\uff1a<\/p>\n<p>\u5efa\u8bae\u63a5\u79cd\u75ab\u82d7\u81f3\u5c114\u5468\u540e\u518d\u5f00\u59cb\u73af\u5b62\u7d20\u6cbb\u7597\uff0c\u73af\u5b62\u7d20\u6cbb\u7597\u505c\u6b62\u540e3\u4e2a\u6708\u5185\u907f\u514d\u63a5\u79cd\u6d3b\u75ab\u82d7\u3002<\/p>\n<p>2. \u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff1a\u786b\u5511\u560c\u5464\u3001\u7532\u6c28\u8776\u5464\u4e5f\u88ab\u7528\u4e8e\u6cbb\u7597\u91cd\u5ea6AD\uff0c\u4f46\u5747\u5c5e\u4e8e\u8d85\u9002\u5e94\u8bc1\u4f7f\u7528\uff0c\u4e8c\u8005\u7597\u6548\u7c7b\u4f3c\u3002\u4f7f\u7528\u786b\u5511\u560c\u5464\u524d\u5efa\u8bae\u8fdb\u884c\u5def\u57fa\u560c\u5464\u7532\u57fa\u8f6c\u79fb\u9176\u57fa\u56e0\u5206\u578b\u68c0\u6d4b\uff0c\u4f7f\u7528\u671f\u95f4\u4e25\u5bc6\u76d1\u6d4b\u8840\u8c61\uff0c\u82e5\u6709\u767d\u7ec6\u80de\u53ca\u8840\u7ea2\u86cb\u767d\u51cf\u5c11\uff0c\u5e94\u7acb\u5373\u505c\u836f\u3002\u7532\u6c28\u8776\u5464\u7528\u836f\u524d\u5e94\u8be2\u95ee\u809d\u75c5\u53f2\u3001\u8840\u6db2\u75c5\u53f2\u53ca\u996e\u9152\u53f2\u7b49\uff0c\u4f7f\u7528\u524d\u53ca\u4f7f\u7528\u671f\u95f4\u4e25\u5bc6\u76d1\u6d4b\u8840\u5e38\u89c4\u3001\u809d\u80be\u529f\u80fd\u3002<\/p>\n<p>\uff08\u4e09\uff09\u7cfb\u7edf\u5e94\u7528\u6fc0\u7d201. \u4e34\u5e8a\u5e94\u7528\u7b56\u7565\uff1a\u4ec5\u7528\u4e8e\u75c5\u60c5\u4e25\u91cd\u3001\u5176\u4ed6\u836f\u7269\u96be\u4ee5\u63a7\u5236\u7684\u6025\u6027\u53d1\u4f5c\u671fAD\u60a3\u8005\uff0c\u5efa\u8bae\u77ed\u671f\u5e94\u7528\u3002\u63a8\u8350\u5242\u91cf\u4e3a0.5 mg\u00b7kg<sup>-1<\/sup>\u00b7d<sup>-1<\/sup>\uff08\u4ee5\u6cfc\u5c3c\u677e\u8ba1\uff09\uff0c\u75c5\u60c5\u63a7\u5236\u540e\u5e94\u5c3d\u5feb\u51cf\u91cf\u6216\u505c\u836f\u3002\u4e0d\u80fd\u7528\u4e8e\u8bf1\u5bfc\u75c5\u60c5\u957f\u671f\u7f13\u89e3\u30022. \u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u53ca\u7ba1\u7406\uff1a\u4f7f\u7528\u524d\u5efa\u8bae\u8fdb\u884c\u611f\u67d3\u7b5b\u67e5\u3002\u4f7f\u7528\u671f\u95f4\u76d1\u6d4b\u611f\u67d3\u3001\u7761\u7720\u969c\u788d\u7b49\u4e0d\u826f\u53cd\u5e94\u3002\u4e0d\u826f\u53cd\u5e94\u4e0e\u6fc0\u7d20\u5242\u91cf\u548c\u7597\u7a0b\u76f8\u5173\u30023. \u7279\u6b8a\u4eba\u7fa4\u7528\u836f\u7ba1\u7406\u598a\u5a20\u671f\/\u54fa\u4e73\u671f\u60a3\u8005\uff1a<\/p>\n<p>\u5c3d\u91cf\u907f\u514d\u4f7f\u7528\u3002<\/p>\n<p>\u513f\u7ae5\u60a3\u8005\uff1a<\/p>\n<p>\u98ce\u9669\u9ad8\uff0c\u9700\u5145\u5206\u6743\u8861\u5229\u5f0a\uff0c\u8c28\u614e\u4f7f\u7528\u3002<\/p>\n<p>\u8001\u5e74\u60a3\u8005\uff1a<\/p>\n<p>\u53d1\u751f\u9ad8\u8840\u538b\u3001\u7cd6\u5c3f\u75c5\u3001\u9aa8\u8d28\u758f\u677e\u98ce\u9669\u5747\u5347\u9ad8\uff0c\u5e94\u8c28\u614e\u4f7f\u7528\u3002<\/p>\n<p>\u809d\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff1a<\/p>\n<p>\u809d\u529f\u80fd\u4e0d\u5168\u8005\u4f18\u5148\u9009\u62e9\u65e0\u9700\u7ecf\u809d\u810f\u6d3b\u5316\u7684\u6cfc\u5c3c\u677e\u9f99\u53ca\u6c22\u5316\u53ef\u7684\u677e\uff0c\u500d\u4ed6\u7c73\u677e\u3001\u5730\u585e\u7c73\u677e\u3001\u7532\u6cfc\u5c3c\u9f99\u5747\u53ef\u7528\u4e8e\u809d\u529f\u80fd\u4e0d\u5168\u8005\u3002\u80be\u529f\u80fd\u4e0d\u5168\u8005\u73b0\u6709\u6307\u5357\u65e0\u660e\u786e\u63a8\u8350\uff0c\u6fc0\u7d20\u53ef\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u80be\u810f\u75c5\uff0c\u4f46\u6fc0\u7d20\u5f15\u8d77\u8840\u538b\u5347\u9ad8\u3001\u6c34\u94a0\u6f74\u7559\u53ef\u80fd\u5f71\u54cd\u80be\u529f\u80fd\uff0c\u9700\u614e\u91cd\u4f7f\u7528\u3002<\/p>\n<p>\uff08\u56db\uff09\u751f\u7269\u5236\u52421. \u5ea6\u666e\u5229\u5c24\u5355\u6297\uff08dupilumab\uff09\uff1a&nbsp;\uff081\uff09\u4e34\u5e8a\u5e94\u7528\u7b56\u7565\uff1a\u6210\u4eba\u521d\u59cb\u5242\u91cf600 mg\uff0c\u540e\u7eed300 mg\u6bcf2\u54681\u6b21\uff0c \u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\u3002\u53ef\u5355\u7528\u6216\u4e0eTCS\u3001TCI\u53ca\u5149\u7597\u8054\u5408\u5e94\u7528\u3002\u9664\u7528\u4e8e\u8bf1\u5bfc\u4e2d\u91cd\u5ea6AD\u7f13\u89e3\uff0c\u4e5f\u53ef\u7528\u4e8e\u7ef4\u6301\u6cbb\u7597\uff0c\u6cbb\u75974\u5e74\u7597\u6548\u6301\u4e45\uff0c\u5b89\u5168\u6027\u826f\u597d\u3002\uff082\uff09\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u53ca\u7ba1\u7406\uff1a\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u773c\u90e8\u4e0d\u826f\u53cd\u5e94\u3001\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5e94\u7b49\u3002(3) \u7279\u6b8a\u4eba\u7fa4\u7528\u836f\u7ba1\u7406\u598a\u5a20\u671f\/\u54fa\u4e73\u671f\u60a3\u8005\uff1a<\/p>\n<p>\u4e0d\u5efa\u8bae\u598a\u5a20\u671f\/\u54fa\u4e73\u671f\u60a3\u8005\u4f7f\u7528\u3002<\/p>\n<p>\u513f\u7ae5\u60a3\u8005\uff1a<\/p>\n<p>6\u4e2a\u6708\u81f35\u5c81\u513f\u7ae5\u63a8\u8350\u5242\u91cf\uff1a\u4f53\u91cd5 ~ &lt; 15 kg\uff0c\u521d\u59cb\u5242\u91cf200 mg\uff0c\u540e\u7eed200 mg\u6bcf4\u54681\u6b21\uff1b15 ~ &lt; 30 kg\uff0c\u521d\u59cb\u5242\u91cf300 mg\uff0c\u540e\u7eed300 mg\u6bcf4\u54681\u6b21\u30026 ~ 17\u5c81\u513f\u7ae5\u63a8\u8350\u5242\u91cf\uff1a\u4f53\u91cd15 ~ &lt; 30 kg\uff0c\u521d\u59cb\u5242\u91cf600 mg\uff0c\u540e\u7eed300 mg\u6bcf4\u54681\u6b21\uff1b30 ~ &lt; 60 kg\uff0c\u521d\u59cb\u5242\u91cf400 mg\uff0c\u540e\u7eed200 mg\u6bcf2\u54681\u6b21\uff1b\u2265 60 kg\uff0c\u521d\u59cb\u5242\u91cf600 mg\uff0c\u540e\u7eed300 mg\u6bcf2\u54681\u6b21\u3002\u5728\u513f\u7ae5\/\u9752\u5c11\u5e74\u4e2d\u7684\u957f\u671f\u5b89\u5168\u6027\u4e0e\u6210\u4eba\u60a3\u8005\u4e00\u81f4\u3002<\/p>\n<p>\u8001\u5e74\u60a3\u8005\uff1a<\/p>\n<p>\u540c\u6210\u4eba\u60a3\u8005\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<\/p>\n<p>\u809d\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff1a<\/p>\n<p>\u5728\u809d\u529f\u80fd\u4e0d\u5168\u8005\u4e2d\u5c1a\u65e0\u6570\u636e\uff1b\u8f7b\/\u4e2d\u5ea6\u80be\u529f\u80fd\u4e0d\u5168\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u4e25\u91cd\u80be\u529f\u80fd\u4e0d\u5168\u8005\u4e2d\u7684\u6570\u636e\u6709\u9650\u3002<\/p>\n<p>\u75ab\u82d7\u63a5\u79cd\u8005\uff1a<\/p>\n<p>\u6cbb\u7597\u671f\u95f4\u53ef\u63a5\u79cd\u706d\u6d3b\u6216\u975e\u6d3b\u75ab\u82d7\u3002\u6d3b\u75ab\u82d7\u548c\u51cf\u6bd2\u6d3b\u75ab\u82d7\u4e0e\u5ea6\u666e\u5229\u5c24\u5355\u6297\u540c\u65f6\u5e94\u7528\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u786e\u5b9a\uff0c\u4e0d\u5efa\u8bae\u540c\u65f6\u5e94\u7528\u3002<\/p>\n<p>2. \u66f2\u7f57\u82a6\u5355\u6297\uff08tralokinumab\uff09\uff1a&nbsp;\uff081\uff09\u4e34\u5e8a\u5e94\u7528\u7b56\u7565\uff1a\u521d\u59cb\u5242\u91cf600 mg\uff0c\u540e\u7eed300 mg\u6bcf2\u54681\u6b21\uff0c\u76ae\u4e0b\u6ce8\u5c04\u3002\u6cbb\u759716\u5468\u540e\u82e5\u76ae\u635f\u6e05\u9664\u6216\u51e0\u4e4e\u6e05\u9664\uff0c\u53ef\u8003\u8651\u6bcf4\u5468\u7ed9\u836f1\u6b21\u3002\u6cbb\u759716\u5468\u65e0\u5e94\u7b54\u7684\u60a3\u8005\u5e94\u505c\u6b62\u6cbb\u7597\u3002\uff082\uff09\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u53ca\u7ba1\u7406\uff1a\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u6cbb\u7597\u671f\u95f4\u65e0\u9700\u5e38\u89c4\u76d1\u6d4b\u3002(3) \u7279\u6b8a\u4eba\u7fa4\u7528\u836f\u7ba1\u7406\u598a\u5a20\u671f\/\u54fa\u4e73\u671f\u60a3\u8005\uff1a<\/p>\n<p>\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u598a\u5a20\u671f\u907f\u514d\u4f7f\u7528\uff0c\u54fa\u4e73\u671f\u82e5\u4f7f\u7528\u9700\u5145\u5206\u6743\u8861\u5229\u5f0a\u3002<\/p>\n<p>\u513f\u7ae5\u60a3\u8005\uff1a<\/p>\n<p>\u5c1a\u65e0\u572812\u5c81\u4ee5\u4e0b\u513f\u7ae5AD\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<\/p>\n<p>\u8001\u5e74\u60a3\u8005\uff1a<\/p>\n<p>\u572875\u5c81\u4ee5\u4e0aAD\u60a3\u8005\u4e2d\u7684\u6570\u636e\u6709\u9650\uff0c\u4e0d\u5efa\u8bae\u8c03\u6574\u5242\u91cf\u3002<\/p>\n<p>\u809d\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff1a<\/p>\n<p>\u8f7b\u5ea6\u809d\u529f\u80fd\u4e0d\u5168\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5728\u4e2d\/\u91cd\u5ea6\u809d\u529f\u80fd\u4e0d\u5168\u8005\u4e2d\u6570\u636e\u6709\u9650\u3002\u8f7b\/\u4e2d\u5ea6\u80be\u529f\u80fd\u4e0d\u5168\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5728\u91cd\u5ea6\u80be\u529f\u80fd\u4e0d\u5168\u8005\u4e2d\u6570\u636e\u6709\u9650\u3002<\/p>\n<p>\u75ab\u82d7\u63a5\u79cd\u8005\uff1a<\/p>\n<p>\u6cbb\u7597\u671f\u95f4\u53ef\u63a5\u79cd\u706d\u6d3b\u6216\u975e\u6d3b\u75ab\u82d7\uff1b\u6d3b\u75ab\u82d7\u548c\u51cf\u6bd2\u6d3b\u75ab\u82d7\u4e0e\u66f2\u7f57\u82a6\u5355\u6297\u540c\u65f6\u5e94\u7528\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u786e\u5b9a\u3002<\/p>\n<p>\uff08\u4e94\uff09 JAK\u6291\u5236\u52421. \u4e34\u5e8a\u5e94\u7528\u7b56\u7565\uff1a\u4e4c\u5e15\u66ff\u5c3c\u5728 \u2265 12\u5c81\u4e14\u4f53\u91cd \u2265 40 kg\u7684\u9752\u5c11\u5e74\u548c\uff1c65\u5c81\u7684\u6210\u4eba\u4e2d\uff0c\u5355\u72ec\u4f7f\u7528\u6216\u4e0e\u5916\u7528\u836f\u7269\u8054\u5408\u4f7f\u7528\u3002\u963f\u5e03\u6614\u66ff\u5c3c\u63a8\u8350\u5242\u91cf\u4e3a100 mg \u6bcf\u65e51\u6b21\u53e3\u670d\uff0c\u91cd\u5ea6\u60a3\u8005\u6216\u672a\u5145\u5206\u5e94\u7b54\u8005\u53ef\u8c03\u6574\u81f3 200 mg \u6bcf\u65e51\u6b21\uff08\u77ed\u671f\u4f7f\u7528\uff0c \u2264 12\u5468\uff09\uff0c\u82e5\u4ecd\u672a\u5145\u5206\u5e94\u7b54\u5219\u505c\u7528\u30022. 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