{"id":39580,"date":"2024-08-12T05:10:18","date_gmt":"2024-08-12T05:10:18","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=39580"},"modified":"2024-08-12T05:10:18","modified_gmt":"2024-08-12T05:10:18","slug":"%e5%9f%ba%e4%ba%8e%e8%84%91%e8%82%a0%e4%ba%a4%e4%ba%92%e6%8e%a2%e8%ae%a8%e9%92%88%e7%81%b8%e6%b2%bb%e7%96%97%e5%8a%9f%e8%83%bd%e6%80%a7%e8%83%83%e8%82%a0%e7%97%85%e7%9a%84%e6%95%88","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=39580","title":{"rendered":"\u57fa\u4e8e\u201c\u8111\u80a0\u4ea4\u4e92\u201d\u63a2\u8ba8\u9488\u7078\u6cbb\u7597\u529f\u80fd\u6027\u80c3\u80a0\u75c5\u7684\u6548\u5e94\u673a\u5236"},"content":{"rendered":"

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\u8d30— \u4e0e\u529f\u80fd\u6027\u80c3\u80a0\u75c5\u75c5\u7406\u76f8\u5173\u7684\u201c\u8111\u80a0\u4ea4\u4e92\u201d\u969c\u788d<\/p>\n

\u201c\u8111\u80a0\u4ea4\u4e92\u201d\u662f\u8111\uff0d\u80a0\u53cc\u5411\u901a\u4fe1\u7684\u52a8\u6001\u4ea4\u6d41\u8fc7\u7a0b\uff0c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u901a\u8fc7\u795e\u7ecf\u6295\u5c04\u548c\u795e\u7ecf\u5185\u5206\u6ccc\u9014\u5f84\u7cbe\u7ec6\u8c03\u63a7\u80c3\u80a0\u529f\u80fd\uff0c\u80c3\u80a0\u795e\u7ecf\u3001\u514d\u75ab\u3001\u5185\u5206\u6ccc\u4fe1\u53f7\u4e0e\u80a0\u9053\u83cc\u7fa4\u4fe1\u53f7\u53cd\u9988\u5f71\u54cd\u4e2d\u67a2\u5bf9\u6d88\u5316\u9053\u4fe1\u53f7\u7684\u5904\u7406\u3002 \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u529f\u80fd\u5f02\u5e38\u4f1a\u5f15\u8d77\u4e0e\u4e4b\u5173\u7cfb\u5bc6\u5207\u7684\u80a0\u795e\u7ecf\u7cfb\u7edf\u529f\u80fd\u6539\u53d8\uff0c\u53cd\u4e4b\u4ea6\u7136\uff0c\u8fd9\u88ab\u79f0\u4e3a\u201c\u8111\u80a0\u4ea4\u4e92\u969c\u788d\u201d\uff0c\u73b0\u6709\u8bc1\u636e\u8868\u660e FGIDs \u7531\u201c\u8111\u80a0\u4ea4\u4e92\u969c\u788d\u201d\u5f15\u8d77\uff0c\u5176\u673a\u5236\u6d89\u53ca\u4e2d\u67a2\uff08\u5fc3\u7406\u5e94\u6fc0\uff09 \u548c\u5916\u5468\uff08\u80c3\u80a0\u7c98\u819c\u708e\u75c7\u3001\u80a0\u9053\u83cc\u7fa4\u7d0a\u4e71\u548c\u5185\u810f\u8d85\u654f\u53cd\u5e94\uff09\u65b9\u9762\u3002<\/p>\n

\u6839\u636e FGIDs\u7684\u751f\u7269\uff0d\u5fc3\u7406\uff0d\u793e\u4f1a\u6a21\u578b\uff0c\u5fc3\u7406\u793e\u4f1a\u56e0\u7d20\u88ab\u8ba4\u4e3a\u662f FGIDs \u7684\u91cd\u8981\u81f4\u75c5\u56e0\u7d20\u4e4b\u4e00\u3002\u8111\u80a0\u8f74\u4e3a\u5fc3\u7406\u5e94\u6fc0\u8bf1\u5bfc\u80c3\u80a0\u529f\u80fd\u7d0a\u4e71\u63d0\u4f9b\u4e86\u81ea\u4e3b\u795e\u7ecf\u548c\u4e0b\u4e18\u8111\uff0d\u5782\u4f53\uff0d\u80be\u4e0a\u817a\u8f74\uff08Hypothalamic\uff0dpituitary\uff0dadre-nal axis\uff0cHPA\uff09 \u4e24\u6761\u4e2d\u67a2\u81f3\u6d88\u5316\u9053\u7684\u4e0b\u884c\u4f20\u51fa\u901a\u8def\uff0c\u80c3\u80a0\u529f\u80fd\u53d7\u81ea\u4e3b\u795e\u7ecf\u652f\u914d\uff0c\u5fc3\u7406\u5e94\u6fc0\u5bfc\u81f4\u4ea4\u611f\u795e\u7ecf\u5f20\u529b\u589e\u52a0\u3001\u8ff7\u8d70\u795e\u7ecf\u5f20\u529b\u964d\u4f4e\uff0c\u81ea\u4e3b\u795e\u7ecf\u529f\u80fd\u7d0a\u4e71\u5f15\u53d1FGIDs\u6d88\u5316\u9053\u75c7\u72b6\uff0c\u5982\u541e\u54bd\u56f0\u96be\u3001\u4fbf\u79d8\u548c\u8179\u6cfb\u7b49 \uff1b \u53e6\u4e00\u6761\u5173\u952e\u901a\u8def\u662fHPA\u8f74\uff0c\u5728\u5fc3\u7406\u5e94\u6fc0\u72b6\u6001\u4e0b\uff0c\u4e2d\u67a2\u8c03\u8282\u4e0b\u4e18\u8111\u91ca\u653e\u4fc3\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\u91ca\u653e\u56e0\u5b50\uff08Cortico- tropin\uff0dreleasing factor\uff0cCRF\uff09\uff0c\u6fc0\u6d3bCRF\u4fe1\u53f7\u901a\u8def\u5f15\u53d1\u5c40\u90e8\u708e\u75c7\u53cd\u5e94\uff0c\u589e\u52a0\u80a0\u4e0a\u76ae\u901a\u900f\u6027\u3002\u6b64\u5916\uff0c\u201c\u8111\u80a0\u4ea4\u4e92\u969c\u788d\u201d\u4f1a\u5bfc\u81f4\u8840\u7ba1\u6d3b\u6027\u80a0\u80bd\uff08 Vasoactive intestinal pep- tide\uff0cVIP\uff09 \u3001P\u7269\u8d28\uff08Substance P\uff0cSP\uff09 \u4e0e 5\uff0d\u7f9f\u8272\u80fa\uff085-hydroxytryptamine\uff0c5\uff0dHT\uff09\u7b49\u795e\u7ecf\u80bd\u8fc7\u5ea6\u5206\u6ccc\u3002\u80a0\u9053\u514d\u75ab\u7cfb\u7edf\u5305\u542b\u591a\u79cd\u514d\u75ab\u7ec6\u80de\uff0c\u5982\u80a5\u5927\u7ec6\u80de\u80fd\u591f\u8868\u8fbe\u591a\u79cd\u53d7\u4f53\u54cd\u5e94\u6765\u81ea\u4e2d\u67a2\u795e\u7ecf\u7684\u6fc0\u7d20\u3001\u795e\u7ecf\u9012\u8d28\u548c\u795e\u7ecf\u80bd\u7684\u523a\u6fc0\uff0c\u6fc0\u6d3b\u7684\u80a5\u5927\u7ec6\u80de\u8131\u9897\u7c92\u4f1a\u8fdb\u4e00\u6b65\u91ca\u653e\u5927\u91cf\u708e\u6027\u56e0\u5b50\u30015\uff0dHT\u3001\u7ec4\u80fa\u4e0e\u86cb\u767d\u9176\uff0c\u52a0\u91cd\u708e\u75c7\u5e76\u6fc0\u6d3b\u80a0\u795e\u7ecf\u5143\u5f15\u8d77\u75db\u89c9\u8fc7\u654f\u3002\u80a0\u9053\u514d\u75ab\u5fae\u73af\u5883\u5931\u8861\u53ef\u80fd\u66f4 \u6613\u4e8e\u6709\u5bb3\u83cc\u7684\u5b9a\u690d\uff0c\u9020\u6210\u80a0\u9053\u83cc\u7fa4\u7d0a\u4e71\u2014\u2014\u2014\u8868\u73b0\u4e3a\u6709\u76ca\u83cc\u6570\u91cf\u51cf\u5c11\uff0c\u6709\u5bb3\u83cc\u6570\u91cf\u589e\u52a0\u3002\u6709\u5bb3\u83cc\u7fa4\u7684\u4ee3\u8c22\u4ea7\u7269\u53ef\u76f4\u63a5\u4f5c\u7528\u4e8e\u80a0\u795e\u7ecf\u5143\u3001\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\u6216\u80a0\u514d\u75ab\u7ec6\u80de\u52a0\u91cd\u708e\u75c7\u548c\u75bc\u75db\u4fe1\u53f7\u4f20\u5bfc\u3002\u6b64\u5916\uff0c\u6025\u6027\u80c3\u80a0\u611f\u67d3\u540e\u90e8\u5206\u60a3\u8005\u80a0\u9ecf\u819c\u4ecd\u5b58\u5728\u7684\u6162\u6027\u708e\u75c7\u4e5f\u662f\u8bf1\u5bfcFGIDs\u53d1\u75c5\u7684\u56e0\u7d20\u4e4b\u4e00\uff0c\u611f\u67d3\u8bf1\u5bfc\u4ea7\u751f\u7684\u7ec6\u80de\u56e0\u5b50\u5982 IL\uff0d1\u03b2\u4e0e\u7ec6\u83cc\u5185\u6bd2\u7d20\u4f1a\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u5f71\u54cd\u4e0b\u4e18\u8111CRF\u795e\u7ecf\u5143\u5e76\u6fc0\u6d3b HPA \u8f74\uff0c\u5bfc\u81f4\u80c3\u80a0\u529f\u80fd\u7d0a\u4e71\u3002<\/p>\n

\u80c3\u80a0\u611f\u89c9\u795e\u7ecf\u5143\u4e0a\u7684\u4f24\u5bb3\u6027\u611f\u53d7\u5668\u88ab\u7c7b\u80f0\u86cb\u767d\u9176\u3001\u7ec4\u80fa\u3001\u524d\u5217\u817a\u7d20\u3001ATP\u3001\u817a\u82f7\u4e0e\u708e\u6027\u56e0\u5b50\u7b49\u708e\u75c7\u4fe1\u53f7\u53cd\u590d\u6fc0\u6d3b\uff0c\u5bfc\u81f4\u5176\u654f\u611f\u5ea6\u548c\u53cd\u5e94\u6027\u589e\u52a0\uff0c\u5f15\u53d1 FGIDs\u201c\u5916\u5468\u75db\u89c9\u654f\u5316\u201d\u3002\u611f\u89c9\u795e\u7ecf\u5143\u4e0a\u7684G\u86cb\u767d\u5076\u8054\u53d7\u4f53\u6fc0\u6d3b\u5bfc\u81f4\u77ac\u65f6\u53d7\u4f53\u7535\u4f4d\u79bb\u5b50\u901a\u9053\uff08Transientre- ceptor potential ion channel\uff0cTRP\uff09\u7684\u5f00\u653e\u4e0e\u654f\u5316\u3002TRPV1\u7684\u6fc0\u6d3b\u5f15\u53d1\u5c40\u90e8CGRP\u3001SP\u7b49\u795e\u7ecf\u80bd\u91ca\u653e\uff0c\u4ece\u800c\u653e\u5927\u75bc\u75db\u4fe1\u53f7 \uff1b TRPV4\u7684\u6fc0\u6d3b\u8bf1\u5bfcATP\u80de\u5410\u5e76\u4f5c\u7528\u4e8e\u9ecf\u819c\u4e0b\u795e\u7ecf\u7684ATP\u53d7\u4f53\u5bfc\u81f4\u5185\u810f\u611f\u89c9\u795e\u7ecf\u5143\u6301\u7eed\u6fc0\u6d3b\u3002\u6b64\u5916\uff0cTRP\u901a\u9053\u8fd8\u80fd\u591f\u76f4\u63a5\u68c0\u6d4b\u5e76\u5bf9\u673a\u68b0\u3001\u6e29\u5ea6\u53ca\u5316\u5b66\u523a\u6fc0\u505a\u51fa\u53cd\u5e94\uff0cFGIDs \u5e38\u5e38\u8868\u73b0\u4e3a\u80c3\u80a0\u5bf9\u673a\u68b0\u6269\u5f20\u3001\u6e29\u5ea6\u3001\u98df\u7269\u53ca\u73af\u5883\uff08\u708e\u75c7\u3001\u80a0\u9053\u83cc\u7fa4\uff09\u523a\u6fc0\u7684\u654f\u611f\u5ea6\u589e\u52a0\uff0c\u8fd9\u4e0eTRP\u901a\u9053\u7684\u654f\u5316\u76f8\u5173\u3002\u4f24\u5bb3\u6027\u4fe1\u53f7\u4ece\u80a0\u9053\u4f20\u5165\u4e2d\u67a2\uff0c\u8c37\u6c28\u9178\u3001\u03b3-\u7f9f\u57fa\u4e01\u9178\u4e0e\u7518\u6c28\u9178\u7b49\u795e\u7ecf\u9012\u8d28\u4ecb\u5bfc\u4e86\u4e2d\u67a2\u654f\u5316\u8fc7\u7a0b\uff0c\u9996\u5148\u654f\u5316\u7684\u90e8\u4f4d\u662f\u810a\u9ad3\u80cc\u89d2\uff0c\u810a\u9ad3\u80cc\u89d2\u6c47\u805a\u5185\u810f\u75bc\u75db\u4fe1\u53f7\uff0c\u6b64\u90e8\u4f4d\u7684\u654f\u5316\u4e0d\u4ec5\u4f1a\u5bfc\u81f4\u5176\u5bf9\u80c3\u80a0\u9053\u7684\u4f24\u5bb3\u6027\u4fe1\u53f7\u53cd\u5e94\u6027\u589e\u5f3a\u3001\u8111\u5e72\u53ca\u4e18\u8111\u76f8\u5173\u6838\u56e2\u5174\u594b\u6027\u589e\u52a0\uff0c\u8fd8\u4f1a\u5bfc\u81f4\u611f\u89c9\u795e\u7ecf\u5143\u5bf9\u8eaf\u4f53\u5176\u4ed6\u523a\u6fc0\u53cd\u5e94\u589e\u52a0\uff0c\u5f15\u8d77\u7275\u6d89\u75db\u3002\u8111\u533a\u7684\u529f\u80fd\u5f02\u5e38\u4e5f\u662f\u5185\u810f\u8d85\u654f\u53cd\u5e94\u53d1\u5c55\u548c\u7ef4\u6301\u7684\u91cd\u8981\u56e0\u7d20\u4e4b\u4e00\u3002\u6709\u7814\u7a76\u8868\u660e\uff0cIBS\u60a3\u8005\u5bf9\u76f4\u80a0\u6269\u5f20\u548c\u75bc\u75db\u7684\u8111\u6fc0\u6d3b\u533a\u57df\u4e0e\u5065\u5eb7\u4eba\u6709\u6240\u4e0d\u540c\uff0c\u4e14\u60c5\u7eea\u548c\u5185\u810f\u611f\u89c9\u52a0\u5de5\u76f8\u5173\u7684\u8111\u533a\u4e5f\u6709\u660e\u663e\u7ed3\u6784\u548c\u529f\u80fd\u8fde\u63a5\u6027\u7684\u6539\u53d8\u3002\u6162\u6027\u75bc\u75db\u5f15\u53d1\u7684\u4e0d\u826f\u60c5\u7eea\u53ef\u80fd\u8fdb\u4e00\u6b65\u52a0\u91cdFGIDs\u60a3\u8005\u75c5\u60c5\uff0c\u9020\u6210\u6076\u6027\u5faa\u73af\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u7ea0\u6b63\u201c\u8111\u80a0\u4ea4\u4e92\u969c\u788d\u201d\u662f\u6cbb\u7597FGIDs\u7684\u5173\u952e\u3002<\/p>\n

\u53c1— \u9488\u7078\u901a\u8fc7\u201c\u8111\u80a0\u4ea4\u4e92\u201d\u6cbb\u7597\u529f\u80fd\u6027\u80c3\u80a0\u75c5\u7684\u6548\u5e94\u673a\u5236  <\/p>\n

3.1  \u9488\u7078\u5bf9\u8111\u80a0\u8f74\u76f8\u5173\u795e\u7ecf\uff0d\u5185\u5206\u6ccc\uff0d\u514d\u75ab\u7f51\u7edc\u7684\u8c03\u8282\u4f5c\u7528\u673a\u5236<\/p>\n

\u9488\u7078\u7684\u4f5c\u7528\u7279\u70b9\u662f\u901a\u8fc7\u6fc0\u53d1\u6216\u8bf1\u5bfc\u4f53\u5185\u7684\u56fa\u6709\u8c03\u8282\u7cfb\u7edf\uff0c\u5373\u795e\u7ecf\uff0d\u5185\u5206\u6ccc\uff0d\u514d\u75ab\u7f51\u7edc\uff08Neuro \uff0dendo- crine \uff0dimmunity net work\uff0cNEI\uff09\uff0c\u6062\u590d\u673a\u4f53\u5185\u7a33\u6001\u3002\u9488\u523a\u4fe1\u53f7\u5728\u4e2d\u67a2\u7ecf\u8fc7\u590d\u6742\u6574\u5408\u540e\uff0c\u53ef\u6fc0\u53d1\u81ea\u4e3b\u795e\u7ecf\u901a\u8def\u3001HPA\u8f74\u8c03\u8282\u4e0b\u6e38\u514d\u75ab\u7f51\u7edc\uff0c\u5e76\u8fdb\u4e00\u6b65\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\uff0c\u8c03\u8282FGIDs\u60a3\u8005\u80c3\u80a0\u7a33\u6001\uff0c\u6062\u590d\u5176\u80c3\u80a0\u529f\u80fd\u3002<\/p>\n

3.1.1   \u901a\u8fc7\u4ea4\u611f\u795e\u7ecf\u810a\u9ad3\u53cd\u5c04\u6291\u5236\u80c3\u8fd0\u52a8 <\/p>\n

\u65e9\u671f\u7814\u7a76\u8868\u660e\uff0c\u9488\u523a\u8179\u90e8\u7a74\u4f4d\u5982\u6c14\u6237\u3001\u6881\u95e8\u53ca\u6c14\u6d77\u80fd\u901a\u8fc7\u6fc0\u6d3b\u80c3\u4ea4\u611f\u795e\u7ecf\u5206\u652f\u4f20\u51fa\u795e\u7ecf\u6d3b\u52a8\u6291\u5236\u80c3\u8fd0\u52a8\u3002<\/p>\n

3.1.2   \u901a\u8fc7\u8ff7\u8d70\uff0d\u80c3\u80a0\u6295\u5c04\u7cfb\u7edf\u4fc3\u8fdb\u80c3\u80a0\u8fd0\u52a8  <\/p>\n

\u7535\u9488\u8db3\u4e09\u91cc\u7a74\u80fd\u591f\u901a\u8fc7\u589e\u52a0\u8ff7\u8d70\u795e\u7ecf\u6d3b\u6027\uff0c\u6291\u5236\u7531\u8ff7\u8d70\u795e\u7ecf\u80c6\u78b1\u80fd\u795e\u7ecf\u5143\u4ecb\u5bfc\u7684\u4ea4\u611f\u795e\u7ecf\u6d3b\u6027\u589e\u5f3a\uff0c\u8fdb\u800c\u6539\u5584FD\u5927\u9f20\u7684\u80c3\u8fd0\u52a8\u5ef6\u8fdf\u3002\u6b64\u5916\uff0c\u7535\u9488\u523a\u6fc0\u56db\u80a2\uff08\u66f2\u6c60\u3001\u4e0a\u5de8\u865a\u4e0e\u8db3\u4e09\u91cc\uff09\u3001\u80cc\u90e8\uff08\u80c3\u4fde\uff09\u548c\u8179\u90e8\uff08\u5929\u67a2\uff09\u7a74\u4f4d\u5747\u80fd\u901a\u8fc7\u6fc0\u6d3b\u80c6\u78b1\u80fd\u901a\u8def\u4fc3\u8fdb\u8fdc\u7aef\u7ed3\u80a0\u8fd0\u52a8\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u7535\u9488\u8db3\u4e09\u91cc\u7a74\u901a\u8fc7\u6291\u5236\u8ff7\u8d70\u795e\u7ecf\u80cc\u6838\u4e2d\u7a81\u89e6\u524d \u03bc-\u963f\u7247\u53d7\u4f53\u8868\u8fbe\uff0c\u589e\u5f3a\u4e86N\uff0d\u7532\u57fa\uff0d\u5929\u51ac\u6c28\u9178\u53d7\u4f53\uff08N\uff0dmethyl\uff0dD\uff0daspartate \uff0dreceptor\uff0cNMDAR\uff09\u4ecb\u5bfc\u7684\u7a81\u89e6\u4f20\u9012\uff0c\u8fdb\u800c\u589e\u5f3a\u8ff7\u8d70\u795e\u7ecf\u6d3b\u52a8\u3002\u53e6\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u7535\u9488\u80c3\u4fde\u540c\u6837\u589e\u52a0\u4e86NMDAR\u4ecb\u5bfc\u7684\u8ff7\u8d70\u795e\u7ecf\u80cc\u6838\u7a81\u89e6\u4f20\u9012\uff0c\u4fc3\u8fdb\u4e86\u80c3\u8fd0\u52a8\uff0c\u8fd9\u63d0\u793a\u8ff7\u8d70\u795e\u7ecf\u4e3b\u8981\u4ecb\u5bfc\u4e86\u9488\u523a\u4fc3\u8fdb\u80c3\u80a0\u8fd0\u52a8\u8fc7\u7a0b\uff0c\u4e14\u8be5\u8fc7\u7a0b\u53ef\u80fd\u5177\u6709\u76f8\u540c\u7684\u4e2d\u67a2\u5185\u673a\u5236\u3002<\/p>\n

3.1.3   \u901a\u8fc7\u8ff7\u8d70\u795e\u7ecf\uff0d\u514d\u75ab\u9014\u5f84\u6297\u708e  <\/p>\n

\u7535\u9488\u8db3\u4e09\u91cc\u7a74\u80fd\u591f\u6291\u5236\u8ff7\u8d70\u795e\u7ecf\u80cc\u6838\u80c6\u78b1\u80fd\u795e\u7ecf\u5143\u4e2d\u7684\u03b3-\u6c28\u57fa\u4e01\u9178A\u578b\u53d7\u4f53\u8868\u8fbe\uff0c\u4ece\u800c\u523a\u6fc0\u8ff7\u8d70\u795e\u7ecf\u6d3b\u52a8\uff0c\u4e0a\u8c03\u80a0\u808c\u4e2d\u4e59\u9170\u80c6\u78b1\uff08Acetylcholine\uff0cAch\uff09\u3001\u03b17 \u70df\u78b1\u578b\u4e59\u9170\u80c6\u78b1\u53d7\u4f53\uff08\u03b17nAChR\uff09\u8868\u8fbe\u6c34\u5e73\uff0c\u5de8\u566c\u7ec6\u80de\u7b49\u5408\u6210\u548c\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u7684\u7ec6\u80de\u4e0aAch\u4e0e\u03b17nAChR\u7ed3\u5408\u540e\u901a\u8fc7\u6fc0\u6d3bJAK\/STAT\u4fe1\u53f7\u901a\u8def\u6291\u5236\u708e\u75c7\u56e0\u5b50\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\uff08TNF-\u03b1\uff09\u3001\u767d\u4ecb\u7d20\uff0d6\uff08IL\uff0d6\uff09\u7684\u91ca\u653e\uff0c\u51cf\u8f7b\u80c3\u80a0\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n

3.1.4   \u901a\u8fc7\u7ea0\u6b63HPA \u8f74\u529f\u80fd\u7d0a\u4e71\u7f13\u89e3\u5185\u810f\u8d85\u654f\u53cd\u5e94<\/p>\n

\u6025\u6027\u7cbe\u795e\u538b\u529b\u72b6\u6001\u4e0b\uff0cFGIDs \u60a3\u8005\u7684HPA\u8f74\u5e38\u8868\u73b0\u4e3a\u8fc7\u5ea6\u6fc0\u6d3b\u72b6\u6001\uff0cCRF\u3001\u4fc3\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\uff08Adreno-cortico\uff0dtropic\uff0dhormone\uff0cACTH\uff09\u663e\u8457\u5347\u9ad8\u3002\u7814\u7a76\u8868\u660e\uff0c\u827e\u7078\u547d\u95e8\u7a74\u80fd\u591f\u964d\u4f4eIBS\u5927\u9f20\u8840\u6e05\u4e2d\u4fc3\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\uff08Corticotropin  releasing  hormone\uff0c CRH\uff09\u3001ACTH\u4e0e\u76ae\u8d28\u916e\u542b\u91cf\u3002 \u7535\u9488\u5929\u67a2\u8db3\u4e09\u91cc\u3001\u4e09\u9634\u4ea4\u4e0e\u592a\u51b2\u7a74\u53ef\u964d\u4f4eIBS\u5927\u9f20\u4e0b\u4e18\u8111\u4e2dCRH\u53ca\u5176\u53d7\u4f53CRH\uff0d1R \u5728\u4e0b\u4e18\u8111\u4e2d\u7684\u8868\u8fbe\uff0c\u6062\u590d\u4e0b\u4e18\u8111CRH\u81f3\u6b63\u5e38\u6c34\u5e73\uff0c\u540c\u65f6\u964d\u4f4e\u80c3\u80a0\u9ecf\u819c\u4e2d CRH\uff0d1R\u8868\u8fbe\u3002   <\/p>\n

3.2   \u9488\u7078\u5bf9\u80a0\u9053\u83cc\u7fa4\u7684\u8c03\u8282\u4f5c\u7528<\/p>\n

\u9488\u7078\u80fd\u591f\u6709\u6548\u8c03\u8282 IBS \u5927\u9f20\u6a21\u578b\u80a0\u9053\u5931\u8861\uff0c\u589e\u52a0\u80a0\u9053\u5fae\u751f\u7269\u591a\u6837\u6027\u53ca\u6709\u76ca\u83cc\u4e30\u5ea6\uff0c\u964d\u4f4e\u6709\u5bb3\u83cc\u4e30\u5ea6\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u5176\u673a\u5236\u53d1\u73b0\u708e\u6027\u5c0f\u4f53\uff0d6\uff08Nod\uff0dlike receptors 6\uff0cNLRP6\uff09 \u53ef\u80fd\u662f\u9488\u7078\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\u7684\u5173\u952e\u9776\u70b9\u3002NLRP6\u5728\u80a0\u9053\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u4e00\u65b9\u9762\u5176\u80fd\u901a\u8fc7\u6291\u5236\u5de8\u566c\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u4e2d\u6838\u56e0\u5b50 NF- \u03baB\u548c\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08MAPK\uff09\u4fe1\u53f7\u4f20\u5bfc\u901a\u8def\uff0c\u4e0b\u8c03\u708e\u6027\u56e0\u5b50\u8868\u8fbe\u8fdb\u800c\u6291\u5236\u708e\u75c7\u53cd\u5e94 \uff1b \u53e6\u4e00\u65b9\u9762\u5176\u80fd\u591f\u901a\u8fc7\u4fc3\u8fdb\u6297\u83cc\u80bd\u5206\u6ccc\uff0c\u53c2\u4e0e\u5851\u9020\u80a0\u9053\u83cc\u7fa4\uff0d\u5bbf\u4e3b\u4e92\u4f5c\u754c\u9762\uff0c\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\u7a33\u6001\u3002Bao CH \u7b49\u53d1\u73b0\uff0c\u827e\u7078\u8db3\u4e09\u91cc\u3001\u5929\u67a2\u7a74\u80fd\u591f\u589e\u52a0IBS\u6a21\u578b\u5927\u9f20\u80a0\u7ec4\u7ec7\u4e2dNLRP6\u7684\u8868\u8fbe\uff0c\u964d\u4f4e\u5927\u80a0\u6746\u83cc\u4e30\u5ea6\uff0c\u5347\u9ad8\u4e73\u9178\u6746\u83cc\u3001\u53cc\u6b67\u6746\u83cc\u548c\u666e\u62c9\u68ad\u83cc\u6570\u91cf\uff0c\u540c\u65f6\u964d\u4f4e\u767d\u4ecb\u7d20\uff0d18\uff08IL\uff0d18\uff09\u7b49\u708e\u75c7\u56e0\u5b50\u8868\u8fbe\uff0c\u6291\u5236\u80a0\u9053\u708e\u75c7\u3002\u7136\u800c\uff0cNLRP6\u662f\u5426\u4ecb\u5bfc\u9488\u523a\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\u7684\u673a\u5236\u8fd8\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n

3.3   \u9488\u7078\u5bf9\u529f\u80fd\u6027\u80c3\u80a0\u75c5\u75db\u89c9\u654f\u5316\u7684\u8c03\u8282\u4f5c\u7528\u673a\u5236<\/p>\n

\u9488\u7078\u80fd\u591f\u7f13\u89e3 FGIDs \u5f15\u8d77\u7684\u8179\u75db\u548c\u7275\u6d89\u75db\uff0c\u5728\u5176\u5916\u5468\u673a\u5236\u65b9\u9762\uff0c\u9488\u7078\u4e00\u65b9\u9762\u901a\u8fc7\u5f71\u54cd\u80a0\u795e\u7ecf\u5143\u2014\u2014\u514d\u75ab\u7ec6\u80de\u4e92\u4f5c\u6539\u5584\u80a0\u9053\u5fae\u73af\u5883\uff0c\u6291\u5236\u4f24\u5bb3\u6027\u4fe1\u53f7\u4ea7\u751f\uff0c\u6539\u5584FGIDs\u5185\u810f\u8d85\u654f\u53cd\u5e94\u3002\u827e\u7078\u6216\u7535\u9488\u53cc\u4fa7\u4e0a\u5de8\u865a\u7a74\u53ef\u964d\u4f4e\u7ed3\u80a0\u4e2d\u80a5\u5927\u7ec6\u80de\u6570\u91cf\u53ca\u80a5\u5927\u7ec6\u80de\u8131\u9897\u7c92\u7387\uff0c\u4e0b\u8c03\u80a5\u5927\u7ec6\u80deTLR4\u8868\u8fbe\u3002TLR4\u8868\u8fbe\u4e8e\u5355\u6838\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c\u80a5\u5927\u7ec6\u80de\u7b49\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u4e2d\uff0c\u5e76\u901a\u8fc7\u6838\u8f6c\u5f55\u56e0\u5b50-\u03baB\uff08NF-\u03baB\uff09\/\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176 \uff08MAPK\uff09\u9014\u5f84\u542f\u52a8\u7ec6\u80de\u5185\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u4fc3\u8fdb\u708e\u75c7\u4ecb\u8d28\u7684\u5408\u6210\u548c\u91ca\u653e\u3002\u56e0\u6b64\uff0c\u6291\u5236\u5176\u6d3b\u5316\u80fd\u591f\u964d\u4f4e\u7ed3\u80a0\u708e\u6027\u56e0\u5b50\u6c34\u5e73\uff0c\u7f13\u89e3IBS\u5927\u9f20\u7684\u5185\u810f\u9ad8\u654f\u611f\u6027\u3002\u6b64\u5916\uff0c\u7535\u9488\u8db3\u4e09\u91cc\u7a74\u53ef\u6291\u5236TLR4\/\u9ad3\u6837\u5206\u5316\u56e0\u5b5088\uff08MyD88\uff09\u901a\u8def\u964d\u4f4e\u7ed3\u80a0\u7ec4\u7ec7M1\u578b\u5de8\u566c\u7ec6\u80de\u8868\u8fbe\uff0c\u4e0a\u8c03M2 \u578b\u5de8\u566c\u7ec6\u80de\u8868\u8fbe\uff0c\u8fdb\u800c\u4e0b\u8c03\u7ed3\u80a0\u5de8\u566c\u7ec6\u80de\u4e2d NLRP3\/IL\uff0d1\u03b2 ,  \u6291\u5236\u7ed3\u80a0\u53ca\u8840\u6e05\u4e2dIL\uff0d6\u3001IL\uff0d12\u3001IL\uff0d17\u3001TNF-\u03b1\u548c\u8840\u6e05\u5e72\u6270\u7d20-\u03b3\uff08IFN -\u03b3\uff09\u7b49\u4fc3\u708e\u56e0\u5b50\u8868\u8fbe\uff0c\u51cf\u8f7b\u80a0\u9053\u708e\u75c7\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u9488\u7078\u80fd\u591f\u901a\u8fc7\u6291\u5236\u5173\u952e\u795e\u7ecf\u80bdSP\u3001\u964d\u9499\u7d20\u76f8\u5173\u57fa\u56e0\u80bd\uff08CGRP\uff09\u53ca5\uff0dHT\u7b49\u8868\u8fbe\uff0c\u6291\u5236\u75db\u89c9\u4fe1\u53f7\u4f20\u5bfc\u3002<\/p>\n

\u4e2d\u67a2\u6c34\u5e73\uff0c\u827e\u7078\u5929\u67a2\u3001\u4e0a\u5de8\u865a\u7a74\u80fd\u591f\u964d\u4f4e\u810a\u9ad3\u80cc\u89d2\u4e2dNR1\u548cNR2B\u7684\u8868\u8fbe\uff0c\u6291\u5236\u5174\u594b\u6027\u8c37\u6c28\u9178\u76d0\u4e0eNMDA\u53d7\u4f53\u7ed3\u5408\uff0c\u51cf\u5c11\u6fc0\u6d3b\u7684\u94a0\u79bb\u5b50\u901a\u9053\u6570\u91cf\uff0c\u4ece\u800c\u6291\u5236\u86cb\u767d\u6fc0\u9176C\u8c03\u8282\u533a\u529f\u80fd\uff0c\u6291\u5236\u4e2d\u67a2\u75db\u89c9\u4f20\u5bfc\u8fc7\u7a0b\u3002\u8fdb\u4e00\u6b65\u7ec6\u80de\u5185\u4fe1\u53f7\u901a\u8def\u8f6c\u5bfc\u7814\u7a76\u53d1\u73b0\u7535\u9488\u8db3\u4e09\u91cc\u3001\u4e0a\u5de8\u865a\u7a74\u80fd\u591f\u6291\u5236\u810a\u9ad3\u80cc\u89d2\u4e2dP2Y1\u53d7\u4f53\u53ca\u5176\u4e0b\u6e38PKC\u548cERK 1\/2\u7684\u78f7\u9178\u5316\uff0c\u8fdb\u4e00\u6b65\u6291\u5236\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u51cf\u8f7b\u795e\u7ecf\u708e\u75c7\uff0c\u6291\u5236\u810a\u9ad3\u6c34\u5e73\u75db\u89c9\u4fe1\u53f7\u4f20\u5bfc\uff0c\u4ece\u800c\u7f13\u89e3IBS\u5927\u9f20\u5185\u810f\u8d85\u654f\u53cd\u5e94\u3002<\/p>\n

\u8086— \u5c0f\u7ed3<\/p>\n

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