{"id":39455,"date":"2024-08-09T05:10:27","date_gmt":"2024-08-09T05:10:27","guid":{"rendered":"https:\/\/zydq.1006ss.com\/?p=39455"},"modified":"2024-08-09T05:10:27","modified_gmt":"2024-08-09T05:10:27","slug":"%e3%80%90%e8%a1%a1%e9%81%93%e4%b8%a8%e7%97%85%e4%be%8b%e3%80%91%e5%ad%a4%e7%ab%8b%e6%80%a7%e7%ba%a4%e7%bb%b4%e6%80%a7%e8%82%bf%e7%98%a4%ef%bc%88solitary-fibrous-tumour%ef%bc%8c-sft%ef%bc%89%e5%a6%82","status":"publish","type":"post","link":"http:\/\/zydq.1006ss.com\/?p=39455","title":{"rendered":"\u3010\u8861\u9053\u4e28\u75c5\u4f8b\u3011\u5b64\u7acb\u6027\u7ea4\u7ef4\u6027\u80bf\u7624\uff08Solitary fibrous tumour\uff0c SFT\uff09\u5982\u4f55\u8bca\u65ad\uff1f"},"content":{"rendered":"

\u4eca\u5929\u5c31\u6765\u770b\u770b\u7531\u6d2a\u65e5\u8001\u5e08\u5e26\u6765\u6709\u5173\u5b64\u7acb\u6027\u7ea4\u7ef4\u6027\u80bf\u7624\u75c5\u7406\u8bca\u65ad\u91cd\u70b9\u6458\u8981\u7684\u5185\u5bb9\u5427\u3002\u6b22\u8fce\u5404\u4f4d\u75c5\u7406\u540c\u4ec1\u6295\u7a3f\uff0c\u5206\u4eab\u5b66\u4e60\u3001\u5de5\u4f5c\u6240\u5f97\u3002<\/p>\n

\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u745e\u91d1\u533b\u9662<\/p>\n

\u75c5\u7406\u79d1\u533b\u5e08   \u6d2a\u65e5<\/p>\n

 \u5b9a\u4e49\uff1a<\/p>\n

\u5b64\u7acb\u6027\u7ea4\u7ef4\u6027\u80bf\u7624\u662f\u4e00\u79cd\u7ea4\u7ef4\u6bcd\u7ec6\u80de\u6027\u80bf\u7624\uff0c\u5176\u7279\u5f81\u662f\u7a81\u51fa\u7684\u5206\u652f\u3001\u8584\u58c1\u3001\u6269\u5f20\uff08\u9e7f\u89d2\u5f62\uff09\u8840\u7ba1\u548cNAB2-STAT6\u57fa\u56e0\u91cd\u6392\u3002<\/p>\n

 \u4e34\u5e8a\u7279\u70b9\uff1a\u5e74\u9f84\uff1a\u8303\u56f419-85\u5c81\uff0c\u53d1\u75c5\u9ad8\u5cf0\u4e3a40-70\u5c81\u3002<\/p>\n

\u90e8\u4f4d\uff1a\u597d\u53d1\u4e8e\u80f8\u819c\uff0c\u90e8\u5206\u75c5\u4f8b\u53ef\u53d1\u751f\u4e8e\u80f8\u819c\u5916\uff0c\u4ee5\u5934\u9888\u90e8\u3001\u4e0a\u547c\u5438\u9053\u3001\u7eb5\u8188\u3001\u76c6\u8154\u3001\u8179\u819c\u540e\u548c\u5468\u56f4\u8f6f\u7ec4\u7ec7\u76f8\u5bf9\u5e38\u89c1\u3002<\/p>\n

\u4e34\u5e8a\u8868\u73b0\uff1a\u56e0\u90e8\u4f4d\u800c\u5f02\uff0c\u5927\u90e8\u5206\u4e3a\u7f13\u6162\u751f\u957f\u7684\u65e0\u75db\u6027\u80bf\u5757\u3002<\/p>\n

 \u5f62\u6001\u5b66\u8bca\u65ad\u8981\u70b9\uff1a<\/p>\n

1.\u5927\u4f53\u5f62\u6001\uff1a\u80bf\u5757\u5927\u5c0f1-20cm\uff0c\u901a\u5e385-10cm\uff1b\u5448\u7c7b\u5706\u5f62\u6216\u5375\u5706\u5f62\uff0c\u5206\u53f6\u72b6\uff0c\u8fb9\u754c\u6e05\u695a\uff0c\u5207\u9762\u7070\u767d\u6216\u8910\u8272\uff0c\u8d28\u97e7\uff1b\u5076\u89c1\u56ca\u6027\u53d8\u6216\u51fa\u8840\u3002<\/p>\n<\/p>\n

\u56fe1 \u5f15\u81eaWHO Classification of Soft Tissue and Bone Tumour<\/p>\n

2. \u7ec4\u7ec7\u5b66\u7ed3\u6784\uff1a\u80bf\u7624\u7ec6\u80de\u758f\u5bc6\u4e0d\u7b49\uff0c\u201c\u65e0\u7ed3\u6784\u6837\u201d\u6392\u5217\uff0c\u5c40\u90e8\u53ef\u663e\u793a\u5e2d\u7eb9\u72b6\u3001\u6881\u72b6\u3001\u758f\u677e\u6761\u675f\u72b6\u3002<\/p>\n

3. \u7ec6\u80de\u5f62\u6001\u7279\u5f81\uff1a\u7ec6\u80de\u5375\u5706\u5f62\u81f3\u68ad\u5f62\uff0c\u80de\u8d28\u7a00\u5c11\uff0c\u7ec6\u80de\u6838\u5706\u5f62\u81f3\u7eba\u9524\u5f62\uff0c\u67d3\u8272\u8d28\u7a7a\u6ce1\u72b6\uff0c\u65e0\u660e\u663e\u5f02\u578b\u6027\uff0c\u6838\u5206\u88c2\u8c61\u5c11\u89c1\uff0c\u901a\u5e38\u65e0\u574f\u6b7b\u30024. \u95f4\u8d28\u7279\u5f81\uff1a\u2460 \u80bf\u7624\u7ec6\u80de\u95f4\u7c97\u7ec6\u4e0d\u5747\u3001\u5f62\u6001\u4e0d\u4e00\u7684\u80f6\u539f\u7ea4\u7ef4\uff08\u5e38\u89c1\u4e3a\u81f4\u5bc6\uff0c\u7622\u75d5\u6837\u73bb\u7483\u6837\u53d8\u6027\uff09\uff1b\u2461 \u7279\u5f81\u6027\u7684\u8840\u7ba1\u7ed3\u6784\uff08\u5206\u652f\u72b6\u6216\u9e7f\u89d2\u72b6\u8840\u7ba1\uff0c\u5e38\u89c1\u8840\u7ba1\u5468\u73bb\u7483\u6837\u53d8\u6027\uff09\u3002<\/p>\n

\u56fe2 \u7ec6\u80de\u758f\u5bc6\u4e0d\u5747\uff0c\u201c\u65e0\u7ed3\u6784\u6837\u201d\u6392\u5217\u7684\u7ec6\u80de\uff0c\u95f4\u8d28\u53ef\u89c1\u80f6\u539f\u7ea4\u7ef4\u7a7f\u63d2\u3002\u5de6\u56fe\uff1a\u9ad8\u5bc6\u5ea6\u533a\uff1b\u53f3\u56fe\uff1a\u4f4e\u5bc6\u5ea6\u533a<\/p>\n

\u56fe3 \u5375\u5706\u5f62\u6216\u77ed\u68ad\u5f62\u7ec6\u80de\uff0c\u6838\u67d3\u8272\u8d28\u8f83\u7ec6\u817b\uff0c\u7ec6\u80de\u65e0\u660e\u663e\u5f02\u578b\u6027<\/p>\n

\u56fe4 \u8584\u58c1\u3001\u5206\u652f\u72b6\u8840\u7ba1\uff0c\u80f6\u539f\u675f\u4f34\u73bb\u7483\u6837\u53d8\u6027<\/p>\n

\u56fe5 \u6e29\u548c\u7684\u201c\u65e0\u7ed3\u6784\u201d\u5f62\u6001\uff0c\u53ef\u89c1\u6269\u5f20\u7684\u8584\u58c1\u8840\u7ba1[3]5. \u975e\u5178\u578b\u6216\u6076\u6027\u6f5c\u80fdSFT\u8bca\u65ad\u6807\u51c6[1]\uff1a\u2460 \u7ec6\u80de\u5bc6\u5ea6\u589e\u52a0\uff1b\u2461 \u7ec6\u80de\u5f02\u578b\u6027\uff1b\u2462 \u6838\u5206\u88c2\u8c61\uff1e4\/10HPF\uff1b\u2463 \u80bf\u7624\u574f\u6b7b\uff1b\u2464 \u6d78\u6da6\u6027\u8fb9\u754c\u3002<\/p>\n

\u56fe6 \u5de6\uff1a\u7ec6\u80de\u5bc6\u5ea6\u9ad8\uff0c\u5448\u660e\u663e\u675f\u5e26\u72b6\u751f\u957f\u6a21\u5f0f\uff0c\u5c0f\u7076\u6027\u80bf\u7624\u574f\u6b7b\uff08\u84dd\u8272\u7bad\u5934\uff09\uff1b\u53f3\uff1a\u660e\u663e\u7684\u6838\u5206\u88c2\u8c61\uff08\u84dd\u8272\u7bad\u5934\uff09\u3002\u56fe7 \u6076\u6027SFT\u53ef\u89c1\u660e\u663e\u7684\u7ec6\u80de\u5f02\u578b\u6027\u548c\u6838\u5206\u88c2\u8c61[4] \u591a\u53d8\u91cf\u8f6c\u79fb\u98ce\u9669\u5206\u5c42\u6a21\u578b\uff1aSFT\u7684\u60a3\u8005\u67095%-10%\u4f1a\u53d1\u751f\u590d\u53d1\u6216\u8f6c\u79fb\uff0c\u4e34\u5e8a\u75c5\u7a0b\u57fa\u4e8e\u7ec4\u7ec7\u5b66\u7279\u5f81\u6765\u9884\u6d4b\u3002\u76ee\u524d\u7b2c\u4e94\u7248WHO\u63a8\u8350\u4f7f\u7528Demicco EG\u7b49\u4eba\u6539\u8fdb\u7684\u98ce\u9669\u5206\u5c42\u6a21\u578b\u3002 <\/p>\n

\u56fe8 SFT\u7684\u8f6c\u79fb\u98ce\u9669\u8bc4\u4f30\u7684\u91cf\u5316\u8868[5]6. SFT\u5176\u4ed6\u7ec4\u7ec7\u5b66\u4e9a\u578b\uff1a<\/p>\n

\u56fe9 \u8102\u80aa\u7624\u6837SFT \uff08\u5f15\u81eaWHO Classification of Soft Tissue and Bone Tumour.\uff09<\/p>\n

\u56fe10 \u5bcc\u542b\u5de8\u7ec6\u80de\u7684SFT\uff08\u5f15\u81eaWHO Classification of Soft Tissue and Bone Tumour.\uff09 <\/p>\n

\u56fe11 \u53bb\u5206\u5316SFT\uff08\u5f15\u81eaWHO Classification of Soft Tissue and Bone Tumour.\uff09<\/p>\n

 \u514d\u75ab\u7ec4\u5316\uff1a1. \uff1e95%\u7684SFT\u663e\u793a\u80bf\u7624\u7ec6\u80de\u6838STAT6\u5f25\u6f2b\u6027\u5f3a\u9633\u6027\u67d3\u8272\uff1b\u591a\u6570\u7624\u7ec6\u80deCD34+\uff0cBCL2+\uff0cCD99+\uff1bki-67\uff1a1-10%\uff0c\u6076\u6027SFT ki-67\u4e3a5-70%\u30022. \u7624\u7ec6\u80deDesmin-\u3001EMA-\u3001CK-\u3001S-100-\u3001SMA-\u30023. \u6076\u6027\u548c\u53bb\u5206\u5316SFT\u7684CD34\u3001BCL2\u67d3\u8272\u51cf\u5f31\uff0cCK\u53ef\u80fd\u9633\u6027\u3002 <\/p>\n

\u56fe12 STAT6\u6807\u8bb0\uff1a\u80bf\u7624\u7ec6\u80de\u6838\u5f25\u6f2b\u5f3a\u9633\u6027\u8868\u8fbe<\/p>\n

 \u5206\u5b50\u68c0\u6d4b\uff1a1. \u7279\u5f02\u6027NAB2-STAT6\u57fa\u56e0\u878d\u5408\uff08RT-PCR\u53ef\u68c0\u6d4b\uff0cFISH\u96be\u4ee5\u68c0\u6d4b\uff09\u30022. \u5168\u57fa\u56e0\u7ec4\u7814\u7a76\u663e\u793aGRIA2\u57fa\u56e0\u9ad8\u8868\u8fbe\u3002 \u9274\u522b\u8bca\u65ad\uff1a1. \u708e\u6027\u808c\u7ea4\u7ef4\u6bcd\u7ec6\u80de\u80bf\u7624\uff08Inflammatory myofibroblastic tumour\uff09\u2460 \u95f4\u8d28\u5185\u4f34\u6709\u5927\u91cf\u7684\u708e\u75c7\u7ec6\u80de\uff0c\u591a\u4e3a\u6210\u719f\u7684\u6d46\u7ec6\u80de\u3001\u6dcb\u5df4\u7ec6\u80de\u548c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\uff0c\u5c11\u6570\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u3002\u2461 \u7624\u7ec6\u80de\u5f25\u6f2b\u8868\u8fbeVimentin\uff0c\u591a\u6570\u75c5\u4f8b\u8868\u8fbe\u03b1-SMA\u548cDesmin\u3002 <\/p>\n

\u56fe13 \u5f15\u81ea\u300a\u8f6f\u7ec4\u7ec7\u80bf\u7624\u8bca\u65ad\u75c5\u7406\u5b66\u300b<\/p>\n

2. \u795e\u7ecf\u9798\u7624\uff08Schwannoma\uff09                                  \u2460 \u7531\u6392\u5217\u6709\u5e8f\u3001\u4ea4\u66ff\u5206\u5e03\u7684\u5bcc\u4e8e\u7ec6\u80de\u6027\u675f\u72b6\u533a\u548c\u758f\u677e\u9ecf\u6db2\u6837\u7f51\u72b6\u533a\u7ec4\u6210\uff0c\u7624\u7ec6\u80de\u5448\u68ad\u5f62\uff0c\u6838\u4e24\u7aef\u5c16\uff0c\u6709\u7279\u5f81\u6027\u7684\u6805\u680f\u72b6\u6392\u5217\u3002\u2461 \u7624\u7ec6\u80de\u8868\u8fbeS-100\uff0cSOX10\uff0cVimentin\u7b49\uff0c\u80bf\u7624\u5bcc\u4e8e\u7ec6\u80de\u533aCD34\u4e3a\u9634\u6027\u3002<\/p>\n

\u56fe14 \u5f15\u81ea\u300a\u8f6f\u7ec4\u7ec7\u80bf\u7624\u8bca\u65ad\u75c5\u7406\u5b66\u300b3. \u80c3\u80a0\u9053\u95f4\u8d28\u7624\uff08Gastrointestinal stromal tumor\uff09 \u2460 \u68ad\u5f62\u7ec6\u80de\u578b\u6700\u5e38\u89c1\uff0c\u6392\u5217\u65b9\u5f0f\u591a\u6837\uff0c\u53ef\u5448\u4ea4\u7ec7\u77ed\u6761\u675f\u72b6\u6216\u65cb\u6da1\u72b6\u6392\u5217\u6216\u9c7c\u9aa8\u6837\u7b49\u3002\u2461 \u7624\u7ec6\u80de\u5e38\u8868\u8fbeCD117\u548cDOG-1\u3002<\/p>\n

\u56fe15 \u5f15\u81ea\u300a\u8f6f\u7ec4\u7ec7\u80bf\u7624\u8bca\u65ad\u75c5\u7406\u5b66\u300b<\/p>\n

4. \u6ed1\u819c\u8089\u7624\uff08\u5355\u76f8\u578b\uff09\uff08Synovial sarcoma, monophasic variant\uff09 \u2460 \u7531\u81f4\u5bc6\u7247\u72b6\u6216\u6761\u675f\u72b6\u6392\u5217\u7684\u5f62\u6001\u4e00\u81f4\u7684\u68ad\u5f62\u7ec6\u80de\u7ec4\u6210\uff0c\u7ec6\u80de\u76f8\u5bf9\u6e29\u548c\uff0c30%\u7684\u75c5\u4f8b\u95f4\u8d28\u53ef\u89c1\u9499\u5316\uff0c\u5bf9\u8bca\u65ad\u6709\u63d0\u793a\u4f5c\u7528\u3002\u2461 \u5e38\u8868\u8fbeCK\uff0cEMA\uff0cTLE1\uff0cCD56\uff0cCD99\uff0c\u4e0d\u8868\u8fbeCD34\uff0cSMA\uff0cDesmin\uff0cSyn\u548cTTF1\u3002<\/p>\n

\u56fe16 \u5f15\u81ea\u300a\u8f6f\u7ec4\u7ec7\u80bf\u7624\u8bca\u65ad\u75c5\u7406\u5b66\u300b\u53c2\u8003\u6587\u732e\u53ca\u4e66\u7c4d<\/p>\n

1.\u300a\u8f6f\u7ec4\u7ec7\u80bf\u7624\u8bca\u65ad\u75c5\u7406\u5b66\u300b \u7b2c3\u7248\uff0c\u738b\u575a\u7b49\u4e3b\u8bd1\u3002<\/p>\n

2. WHO Classification of Soft Tissue and Bone Tumour\u00b7 5th Edition.  3. STERNBERG\u2019S DIAGNOSTIC SURGICAL PATHOLOGY, 6th Edition. 4. Zhang J, Liu J, Zhang Z, Tian B. Solitary Fibrous Tumors of the Chest: An Analysis of Fifty Patients. Front Oncol. 2021 Jul 1;11:697156. doi: 10.3389\/fonc.2021.697156.5. Demicco EG, Wagner MJ, Maki RG, et al. Risk assessment in solitary fibrous tumors: validation and refinement of a risk stratification model. Mod Pathol. 2017 Oct;30(10):1433-42. PMID:28731041 \u8bbe\u8ba1\uff1a\u9e4f\u98de\u7f16\u8f91\uff1ayoyi<\/p>\n","protected":false},"excerpt":{"rendered":"

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